-- dump date 20140619_155629 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1138871000001 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1138871000002 active site 1138871000003 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1138871000004 non-prolyl cis peptide bond; other site 1138871000005 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1138871000006 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1138871000007 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 1138871000008 Flavin binding site [chemical binding]; other site 1138871000009 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1138871000010 MULE transposase domain; Region: MULE; pfam10551 1138871000011 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1138871000012 Transposase; Region: HTH_Tnp_1; pfam01527 1138871000013 HTH-like domain; Region: HTH_21; pfam13276 1138871000014 threonine synthase; Validated; Region: PRK08329 1138871000015 Transport protein; Region: actII; TIGR00833 1138871000016 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871000017 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871000018 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871000019 Cytochrome P450; Region: p450; cl12078 1138871000020 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871000021 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871000022 active site 1138871000023 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1138871000024 MULE transposase domain; Region: MULE; pfam10551 1138871000025 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871000026 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871000027 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 1138871000028 active site 1138871000029 diiron metal binding site [ion binding]; other site 1138871000030 SCP-2 sterol transfer family; Region: SCP2; cl01225 1138871000031 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1138871000032 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 1138871000033 dimer interface [polypeptide binding]; other site 1138871000034 acyl-activating enzyme (AAE) consensus motif; other site 1138871000035 putative active site [active] 1138871000036 AMP binding site [chemical binding]; other site 1138871000037 putative CoA binding site [chemical binding]; other site 1138871000038 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1138871000039 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1138871000040 NAD binding site [chemical binding]; other site 1138871000041 catalytic Zn binding site [ion binding]; other site 1138871000042 substrate binding site [chemical binding]; other site 1138871000043 structural Zn binding site [ion binding]; other site 1138871000044 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 1138871000045 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1138871000046 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 1138871000047 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1138871000048 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1138871000049 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871000050 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138871000051 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138871000052 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1138871000053 PHB binding site; other site 1138871000054 CoenzymeA binding site [chemical binding]; other site 1138871000055 subunit interaction site [polypeptide binding]; other site 1138871000056 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871000057 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871000058 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871000059 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871000060 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871000061 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871000062 Integrase core domain; Region: rve; pfam00665 1138871000063 Integrase core domain; Region: rve_3; pfam13683 1138871000064 tail fiber protein; Region: PHA00430 1138871000065 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1138871000066 Zn2+ binding site [ion binding]; other site 1138871000067 Mg2+ binding site [ion binding]; other site 1138871000068 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 1138871000069 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1138871000070 Walker A motif; other site 1138871000071 ATP binding site [chemical binding]; other site 1138871000072 Walker B motif; other site 1138871000073 major cell surface glycoprotein; Region: halo_surf_glyco; TIGR04216 1138871000074 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 1138871000075 AAA-like domain; Region: AAA_10; pfam12846 1138871000076 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1138871000077 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138871000078 Walker A motif; other site 1138871000079 ATP binding site [chemical binding]; other site 1138871000080 Walker B motif; other site 1138871000081 arginine finger; other site 1138871000082 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1138871000083 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1138871000084 catalytic residues [active] 1138871000085 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 1138871000086 active site 1138871000087 catalytic residues [active] 1138871000088 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 1138871000089 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 1138871000090 AAA domain; Region: AAA_31; pfam13614 1138871000091 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1138871000092 EspG family; Region: ESX-1_EspG; pfam14011 1138871000093 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1138871000094 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1138871000095 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871000096 PPE family; Region: PPE; pfam00823 1138871000097 PE family; Region: PE; pfam00934 1138871000098 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1138871000099 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138871000100 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1138871000101 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138871000102 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138871000103 Protein of unknown function (DUF690); Region: DUF690; cl04939 1138871000104 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1138871000105 NlpC/P60 family; Region: NLPC_P60; pfam00877 1138871000106 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4423 1138871000107 Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; cl17690 1138871000108 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1138871000109 non-specific DNA binding site [nucleotide binding]; other site 1138871000110 salt bridge; other site 1138871000111 sequence-specific DNA binding site [nucleotide binding]; other site 1138871000112 Transcription factor WhiB; Region: Whib; pfam02467 1138871000113 Helicase associated domain; Region: HA; pfam03457 1138871000114 Helicase associated domain; Region: HA; pfam03457 1138871000115 Helicase associated domain; Region: HA; pfam03457 1138871000116 Helicase associated domain; Region: HA; pfam03457 1138871000117 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1138871000118 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 1138871000119 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 1138871000120 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1138871000121 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1138871000122 P-loop; other site 1138871000123 Magnesium ion binding site [ion binding]; other site 1138871000124 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 1138871000125 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 1138871000126 ribonuclease E; Reviewed; Region: rne; PRK10811 1138871000127 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1138871000128 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1138871000129 active site 1138871000130 DNA binding site [nucleotide binding] 1138871000131 Int/Topo IB signature motif; other site 1138871000132 ParB-like nuclease domain; Region: ParB; smart00470 1138871000133 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1138871000134 DNA-binding interface [nucleotide binding]; DNA binding site 1138871000135 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1138871000136 catalytic residues [active] 1138871000137 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 1138871000138 active site 1138871000139 metal binding site [ion binding]; metal-binding site 1138871000140 interdomain interaction site; other site 1138871000141 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1138871000142 Domain of unknown function (DUF932); Region: DUF932; pfam06067 1138871000143 Domain of unknown function (DUF3846); Region: DUF3846; pfam12957 1138871000144 TrwC relaxase; Region: TrwC; pfam08751 1138871000145 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 1138871000146 AAA domain; Region: AAA_30; pfam13604 1138871000147 Family description; Region: UvrD_C_2; pfam13538 1138871000148 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1138871000149 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1138871000150 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1138871000151 Probable transposase; Region: OrfB_IS605; pfam01385 1138871000152 transketolase, bacterial and yeast; Region: tktlase_bact; TIGR00232 1138871000153 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 1138871000154 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1138871000155 ParA-like protein; Provisional; Region: PHA02518 1138871000156 P-loop; other site 1138871000157 Magnesium ion binding site [ion binding]; other site 1138871000158 PemK-like protein; Region: PemK; pfam02452 1138871000159 Protein of unknown function (DUF3018); Region: DUF3018; pfam11455 1138871000160 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1138871000161 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138871000162 Walker A motif; other site 1138871000163 ATP binding site [chemical binding]; other site 1138871000164 Walker B motif; other site 1138871000165 arginine finger; other site 1138871000166 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1138871000167 DnaA box-binding interface [nucleotide binding]; other site 1138871000168 DNA polymerase III subunit beta; Validated; Region: PRK07761 1138871000169 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1138871000170 putative DNA binding surface [nucleotide binding]; other site 1138871000171 dimer interface [polypeptide binding]; other site 1138871000172 beta-clamp/clamp loader binding surface; other site 1138871000173 beta-clamp/translesion DNA polymerase binding surface; other site 1138871000174 recombination protein F; Reviewed; Region: recF; PRK00064 1138871000175 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1138871000176 Walker A/P-loop; other site 1138871000177 ATP binding site [chemical binding]; other site 1138871000178 Q-loop/lid; other site 1138871000179 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138871000180 ABC transporter signature motif; other site 1138871000181 Walker B; other site 1138871000182 D-loop; other site 1138871000183 H-loop/switch region; other site 1138871000184 hypothetical protein; Provisional; Region: PRK03195 1138871000185 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1138871000186 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138871000187 Mg2+ binding site [ion binding]; other site 1138871000188 G-X-G motif; other site 1138871000189 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1138871000190 anchoring element; other site 1138871000191 dimer interface [polypeptide binding]; other site 1138871000192 ATP binding site [chemical binding]; other site 1138871000193 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1138871000194 active site 1138871000195 putative metal-binding site [ion binding]; other site 1138871000196 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1138871000197 DNA gyrase subunit A; Validated; Region: PRK05560 1138871000198 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1138871000199 CAP-like domain; other site 1138871000200 active site 1138871000201 primary dimer interface [polypeptide binding]; other site 1138871000202 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1138871000203 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1138871000204 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1138871000205 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1138871000206 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1138871000207 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1138871000208 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1138871000209 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871000210 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871000211 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871000212 Cytochrome P450; Region: p450; cl12078 1138871000213 Protein of unknown function (DUF2562); Region: DUF2562; pfam10814 1138871000214 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1138871000215 active site 1138871000216 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1138871000217 putative septation inhibitor protein; Reviewed; Region: PRK00159 1138871000218 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1138871000219 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1138871000220 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1138871000221 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1138871000222 glutamine binding [chemical binding]; other site 1138871000223 catalytic triad [active] 1138871000224 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1138871000225 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1138871000226 active site 1138871000227 ATP binding site [chemical binding]; other site 1138871000228 substrate binding site [chemical binding]; other site 1138871000229 activation loop (A-loop); other site 1138871000230 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1138871000231 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1138871000232 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1138871000233 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1138871000234 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1138871000235 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1138871000236 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1138871000237 active site 1138871000238 ATP binding site [chemical binding]; other site 1138871000239 substrate binding site [chemical binding]; other site 1138871000240 activation loop (A-loop); other site 1138871000241 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1138871000242 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1138871000243 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1138871000244 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1138871000245 active site 1138871000246 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1138871000247 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138871000248 phosphopeptide binding site; other site 1138871000249 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1138871000250 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138871000251 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1138871000252 phosphopeptide binding site; other site 1138871000253 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1138871000254 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1138871000255 DinB superfamily; Region: DinB_2; pfam12867 1138871000256 acyl carrier protein; Validated; Region: PRK05883 1138871000257 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 1138871000258 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871000259 acyl-activating enzyme (AAE) consensus motif; other site 1138871000260 AMP binding site [chemical binding]; other site 1138871000261 active site 1138871000262 CoA binding site [chemical binding]; other site 1138871000263 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1138871000264 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1138871000265 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 1138871000266 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1138871000267 Coenzyme A binding pocket [chemical binding]; other site 1138871000268 Pirin-related protein [General function prediction only]; Region: COG1741 1138871000269 Pirin; Region: Pirin; pfam02678 1138871000270 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1138871000271 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871000272 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871000273 active site 1138871000274 Transcription factor WhiB; Region: Whib; pfam02467 1138871000275 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1138871000276 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1138871000277 non-specific DNA binding site [nucleotide binding]; other site 1138871000278 salt bridge; other site 1138871000279 sequence-specific DNA binding site [nucleotide binding]; other site 1138871000280 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1138871000281 NlpC/P60 family; Region: NLPC_P60; pfam00877 1138871000282 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 1138871000283 Domain of unknown function (DUF4226); Region: DUF4226; pfam10774 1138871000284 Protein of unknown function (DUF2580); Region: DUF2580; pfam10824 1138871000285 Protein of unknown function (DUF2694); Region: DUF2694; pfam10904 1138871000286 Protein of unknown function (DUF2710); Region: DUF2710; pfam10921 1138871000287 TIGR03084 family protein; Region: TIGR03084 1138871000288 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1138871000289 Wyosine base formation; Region: Wyosine_form; pfam08608 1138871000290 H+ Antiporter protein; Region: 2A0121; TIGR00900 1138871000291 hypothetical protein; Validated; Region: PRK00228 1138871000292 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1138871000293 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1138871000294 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1138871000295 active site 1138871000296 HIGH motif; other site 1138871000297 nucleotide binding site [chemical binding]; other site 1138871000298 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1138871000299 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1138871000300 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1138871000301 active site 1138871000302 KMSKS motif; other site 1138871000303 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1138871000304 tRNA binding surface [nucleotide binding]; other site 1138871000305 short chain dehydrogenase; Provisional; Region: PRK08219 1138871000306 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871000307 NAD(P) binding site [chemical binding]; other site 1138871000308 active site 1138871000309 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1138871000310 MarR family; Region: MarR; pfam01047 1138871000311 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138871000312 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1138871000313 Walker A/P-loop; other site 1138871000314 ATP binding site [chemical binding]; other site 1138871000315 Q-loop/lid; other site 1138871000316 ABC transporter signature motif; other site 1138871000317 Walker B; other site 1138871000318 D-loop; other site 1138871000319 H-loop/switch region; other site 1138871000320 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1138871000321 substrate binding pocket [chemical binding]; other site 1138871000322 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1138871000323 membrane-bound complex binding site; other site 1138871000324 hinge residues; other site 1138871000325 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138871000326 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1138871000327 dimer interface [polypeptide binding]; other site 1138871000328 conserved gate region; other site 1138871000329 putative PBP binding loops; other site 1138871000330 ABC-ATPase subunit interface; other site 1138871000331 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1138871000332 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138871000333 DNA-binding site [nucleotide binding]; DNA binding site 1138871000334 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 1138871000335 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138871000336 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138871000337 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1138871000338 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 1138871000339 active site 1138871000340 FMN binding site [chemical binding]; other site 1138871000341 substrate binding site [chemical binding]; other site 1138871000342 putative catalytic residue [active] 1138871000343 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871000344 NAD(P) binding site [chemical binding]; other site 1138871000345 active site 1138871000346 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138871000347 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1138871000348 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1138871000349 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1138871000350 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138871000351 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 1138871000352 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 1138871000353 Predicted transcriptional regulators [Transcription]; Region: COG1695 1138871000354 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1138871000355 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1138871000356 Transglycosylase; Region: Transgly; pfam00912 1138871000357 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1138871000358 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1138871000359 Predicted integral membrane protein [Function unknown]; Region: COG5650 1138871000360 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1138871000361 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1138871000362 conserved cys residue [active] 1138871000363 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1138871000364 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1138871000365 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1138871000366 dimer interface [polypeptide binding]; other site 1138871000367 ssDNA binding site [nucleotide binding]; other site 1138871000368 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1138871000369 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1138871000370 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1138871000371 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1138871000372 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1138871000373 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1138871000374 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1138871000375 Walker A motif; other site 1138871000376 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl17442 1138871000377 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1138871000378 Walker A motif; other site 1138871000379 ATP binding site [chemical binding]; other site 1138871000380 Walker B motif; other site 1138871000381 DNA binding loops [nucleotide binding] 1138871000382 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 1138871000383 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1138871000384 protein-splicing catalytic site; other site 1138871000385 thioester formation/cholesterol transfer; other site 1138871000386 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1138871000387 protein-splicing catalytic site; other site 1138871000388 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1138871000389 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871000390 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871000391 Transport protein; Region: actII; TIGR00833 1138871000392 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1138871000393 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1138871000394 DNA-binding site [nucleotide binding]; DNA binding site 1138871000395 RNA-binding motif; other site 1138871000396 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1138871000397 SnoaL-like domain; Region: SnoaL_4; pfam13577 1138871000398 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1138871000399 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871000400 NAD(P) binding site [chemical binding]; other site 1138871000401 active site 1138871000402 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871000403 Cytochrome P450; Region: p450; cl12078 1138871000404 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1138871000405 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138871000406 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138871000407 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1138871000408 active site 1138871000409 metal binding site [ion binding]; metal-binding site 1138871000410 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1138871000411 classical (c) SDRs; Region: SDR_c; cd05233 1138871000412 NAD(P) binding site [chemical binding]; other site 1138871000413 active site 1138871000414 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1138871000415 FMN binding site [chemical binding]; other site 1138871000416 dimer interface [polypeptide binding]; other site 1138871000417 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138871000418 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871000419 NAD(P) binding site [chemical binding]; other site 1138871000420 active site 1138871000421 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1138871000422 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1138871000423 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871000424 Cytochrome P450; Region: p450; cl12078 1138871000425 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871000426 Cytochrome P450; Region: p450; cl12078 1138871000427 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871000428 short chain dehydrogenase; Provisional; Region: PRK08303 1138871000429 NAD(P) binding site [chemical binding]; other site 1138871000430 active site 1138871000431 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1138871000432 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1138871000433 active site 1138871000434 non-prolyl cis peptide bond; other site 1138871000435 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1138871000436 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1138871000437 active site 1138871000438 iron coordination sites [ion binding]; other site 1138871000439 substrate binding pocket [chemical binding]; other site 1138871000440 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871000441 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871000442 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871000443 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871000444 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1138871000445 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1138871000446 putative dimer interface [polypeptide binding]; other site 1138871000447 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138871000448 classical (c) SDRs; Region: SDR_c; cd05233 1138871000449 NAD(P) binding site [chemical binding]; other site 1138871000450 active site 1138871000451 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1138871000452 FAD binding domain; Region: FAD_binding_4; pfam01565 1138871000453 Berberine and berberine like; Region: BBE; pfam08031 1138871000454 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1138871000455 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1138871000456 ligand binding site [chemical binding]; other site 1138871000457 flexible hinge region; other site 1138871000458 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1138871000459 putative switch regulator; other site 1138871000460 non-specific DNA interactions [nucleotide binding]; other site 1138871000461 DNA binding site [nucleotide binding] 1138871000462 sequence specific DNA binding site [nucleotide binding]; other site 1138871000463 putative cAMP binding site [chemical binding]; other site 1138871000464 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138871000465 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138871000466 PGAP1-like protein; Region: PGAP1; pfam07819 1138871000467 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1138871000468 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 1138871000469 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1138871000470 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1138871000471 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138871000472 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1138871000473 active site 1138871000474 Permease; Region: Permease; pfam02405 1138871000475 Permease; Region: Permease; pfam02405 1138871000476 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1138871000477 mce related protein; Region: MCE; pfam02470 1138871000478 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1138871000479 mce related protein; Region: MCE; pfam02470 1138871000480 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138871000481 mce related protein; Region: MCE; pfam02470 1138871000482 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138871000483 mce related protein; Region: MCE; pfam02470 1138871000484 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138871000485 mce related protein; Region: MCE; pfam02470 1138871000486 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1138871000487 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138871000488 mce related protein; Region: MCE; pfam02470 1138871000489 Mannan-binding protein; Region: MVL; pfam12151 1138871000490 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871000491 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871000492 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871000493 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871000494 methanogenesis imperfect marker protein 11; Region: methan_mark_11; TIGR03280 1138871000495 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1138871000496 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871000497 PPE family; Region: PPE; pfam00823 1138871000498 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871000499 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1138871000500 S-adenosylmethionine binding site [chemical binding]; other site 1138871000501 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138871000502 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138871000503 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1138871000504 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1138871000505 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1138871000506 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1138871000507 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138871000508 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1138871000509 Hydroxy(phenyl)pyruvate Reductase, D-isomer-specific 2-hydroxyacid-related dehydrogenase; Region: HPPR; cd12156 1138871000510 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1138871000511 putative ligand binding site [chemical binding]; other site 1138871000512 NAD binding site [chemical binding]; other site 1138871000513 catalytic site [active] 1138871000514 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1138871000515 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1138871000516 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871000517 Cytochrome P450; Region: p450; cl12078 1138871000518 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1138871000519 metal ion-dependent adhesion site (MIDAS); other site 1138871000520 MoxR-like ATPases [General function prediction only]; Region: COG0714 1138871000521 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138871000522 Walker A motif; other site 1138871000523 ATP binding site [chemical binding]; other site 1138871000524 Walker B motif; other site 1138871000525 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 1138871000526 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1138871000527 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871000528 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138871000529 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1138871000530 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138871000531 metabolite-proton symporter; Region: 2A0106; TIGR00883 1138871000532 putative substrate translocation pore; other site 1138871000533 Hemerythrin-like domain; Region: Hr-like; cd12108 1138871000534 Fe binding site [ion binding]; other site 1138871000535 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1138871000536 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871000537 S-adenosylmethionine binding site [chemical binding]; other site 1138871000538 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1138871000539 active site 1138871000540 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1138871000541 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1138871000542 putative active site [active] 1138871000543 putative CoA binding site [chemical binding]; other site 1138871000544 nudix motif; other site 1138871000545 metal binding site [ion binding]; metal-binding site 1138871000546 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1138871000547 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138871000548 motif II; other site 1138871000549 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138871000550 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138871000551 Predicted transcriptional regulators [Transcription]; Region: COG1695 1138871000552 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1138871000553 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1138871000554 SnoaL-like domain; Region: SnoaL_2; pfam12680 1138871000555 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1138871000556 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138871000557 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1138871000558 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138871000559 hypothetical protein; Provisional; Region: PRK01346 1138871000560 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1138871000561 Coenzyme A binding pocket [chemical binding]; other site 1138871000562 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871000563 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871000564 active site 1138871000565 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871000566 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871000567 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1138871000568 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1138871000569 dimer interface [polypeptide binding]; other site 1138871000570 phosphorylation site [posttranslational modification] 1138871000571 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138871000572 ATP binding site [chemical binding]; other site 1138871000573 Mg2+ binding site [ion binding]; other site 1138871000574 G-X-G motif; other site 1138871000575 PPE family; Region: PPE; pfam00823 1138871000576 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1138871000577 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1138871000578 EspG family; Region: ESX-1_EspG; pfam14011 1138871000579 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1138871000580 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1138871000581 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1138871000582 catalytic residues [active] 1138871000583 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1138871000584 catalytic residues [active] 1138871000585 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1138871000586 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1138871000587 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138871000588 Walker A motif; other site 1138871000589 ATP binding site [chemical binding]; other site 1138871000590 Walker B motif; other site 1138871000591 arginine finger; other site 1138871000592 Domain of unknown function (DUF385); Region: DUF385; cl04387 1138871000593 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1138871000594 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871000595 NAD(P) binding site [chemical binding]; other site 1138871000596 active site 1138871000597 RNA polymerase sigma factor SigI; Provisional; Region: sigI; PRK09635 1138871000598 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138871000599 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1138871000600 DNA binding residues [nucleotide binding] 1138871000601 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1138871000602 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1138871000603 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1138871000604 active site 1138871000605 dimer interface [polypeptide binding]; other site 1138871000606 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1138871000607 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1138871000608 active site 1138871000609 FMN binding site [chemical binding]; other site 1138871000610 substrate binding site [chemical binding]; other site 1138871000611 3Fe-4S cluster binding site [ion binding]; other site 1138871000612 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1138871000613 domain interface; other site 1138871000614 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1138871000615 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138871000616 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1138871000617 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138871000618 hypothetical protein; Provisional; Region: PRK07945 1138871000619 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1138871000620 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1138871000621 active site 1138871000622 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1138871000623 DNA polymerase IV; Validated; Region: PRK03858 1138871000624 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1138871000625 active site 1138871000626 DNA binding site [nucleotide binding] 1138871000627 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871000628 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871000629 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138871000630 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138871000631 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1138871000632 CopC domain; Region: CopC; pfam04234 1138871000633 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1138871000634 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1138871000635 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1138871000636 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1138871000637 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 1138871000638 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 1138871000639 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1138871000640 putative active site [active] 1138871000641 catalytic site [active] 1138871000642 putative metal binding site [ion binding]; other site 1138871000643 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 1138871000644 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432 1138871000645 prephenate dehydratase; Provisional; Region: PRK11898 1138871000646 Prephenate dehydratase; Region: PDT; pfam00800 1138871000647 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1138871000648 putative L-Phe binding site [chemical binding]; other site 1138871000649 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1138871000650 catalytic core [active] 1138871000651 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1138871000652 Septum formation; Region: Septum_form; pfam13845 1138871000653 Septum formation; Region: Septum_form; pfam13845 1138871000654 seryl-tRNA synthetase; Provisional; Region: PRK05431 1138871000655 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1138871000656 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1138871000657 dimer interface [polypeptide binding]; other site 1138871000658 active site 1138871000659 motif 1; other site 1138871000660 motif 2; other site 1138871000661 motif 3; other site 1138871000662 Cupin domain; Region: Cupin_2; cl17218 1138871000663 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1138871000664 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1138871000665 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1138871000666 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871000667 S-adenosylmethionine binding site [chemical binding]; other site 1138871000668 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1138871000669 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 1138871000670 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1138871000671 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871000672 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1138871000673 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138871000674 RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678 1138871000675 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1138871000676 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1138871000677 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1138871000678 iron-sulfur cluster [ion binding]; other site 1138871000679 [2Fe-2S] cluster binding site [ion binding]; other site 1138871000680 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1138871000681 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1138871000682 putative acyl-acceptor binding pocket; other site 1138871000683 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1138871000684 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1138871000685 putative acyl-acceptor binding pocket; other site 1138871000686 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1138871000687 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1138871000688 putative acyl-acceptor binding pocket; other site 1138871000689 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138871000690 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1138871000691 active site 1138871000692 motif I; other site 1138871000693 motif II; other site 1138871000694 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138871000695 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1138871000696 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1138871000697 amidase catalytic site [active] 1138871000698 Zn binding residues [ion binding]; other site 1138871000699 substrate binding site [chemical binding]; other site 1138871000700 LGFP repeat; Region: LGFP; pfam08310 1138871000701 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1138871000702 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138871000703 UDP-galactopyranose mutase; Region: GLF; pfam03275 1138871000704 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1138871000705 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1138871000706 active site 1138871000707 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1138871000708 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 1138871000709 Predicted esterase [General function prediction only]; Region: COG0627 1138871000710 Putative esterase; Region: Esterase; pfam00756 1138871000711 Cutinase; Region: Cutinase; pfam01083 1138871000712 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 1138871000713 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1138871000714 acyl-activating enzyme (AAE) consensus motif; other site 1138871000715 active site 1138871000716 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138871000717 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138871000718 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1138871000719 active site 1138871000720 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1138871000721 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1138871000722 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138871000723 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1138871000724 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1138871000725 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1138871000726 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1138871000727 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1138871000728 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138871000729 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138871000730 DNA binding residues [nucleotide binding] 1138871000731 RibD C-terminal domain; Region: RibD_C; cl17279 1138871000732 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871000733 active site 1138871000734 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871000735 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1138871000736 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 1138871000737 ligand binding site [chemical binding]; other site 1138871000738 flexible hinge region; other site 1138871000739 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1138871000740 putative switch regulator; other site 1138871000741 non-specific DNA interactions [nucleotide binding]; other site 1138871000742 DNA binding site [nucleotide binding] 1138871000743 sequence specific DNA binding site [nucleotide binding]; other site 1138871000744 putative cAMP binding site [chemical binding]; other site 1138871000745 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1138871000746 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138871000747 phosphopeptide binding site; other site 1138871000748 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1138871000749 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1138871000750 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1138871000751 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1138871000752 MDMPI C-terminal domain; Region: MDMPI_C; pfam07398 1138871000753 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 1138871000754 putative hydrophobic ligand binding site [chemical binding]; other site 1138871000755 CLM binding site; other site 1138871000756 L1 loop; other site 1138871000757 DNA binding site [nucleotide binding] 1138871000758 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1138871000759 putative DNA binding site [nucleotide binding]; other site 1138871000760 putative Zn2+ binding site [ion binding]; other site 1138871000761 Mycobacterial cell wall arabinan synthesis protein; Region: Arabinose_trans; pfam04602 1138871000762 Arabinofuranosyltransferase N terminal; Region: AftA_N; pfam12250 1138871000763 Arabinofuranosyltransferase A C terminal; Region: AftA_C; pfam12249 1138871000764 short chain dehydrogenase; Provisional; Region: PRK07904 1138871000765 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1138871000766 NAD(P) binding site [chemical binding]; other site 1138871000767 active site 1138871000768 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1138871000769 FAD binding domain; Region: FAD_binding_4; pfam01565 1138871000770 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 1138871000771 Predicted membrane protein [Function unknown]; Region: COG2246 1138871000772 GtrA-like protein; Region: GtrA; pfam04138 1138871000773 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05892 1138871000774 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1138871000775 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138871000776 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138871000777 active site 1138871000778 Integrase core domain; Region: rve; pfam00665 1138871000779 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1138871000780 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1138871000781 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1138871000782 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1138871000783 active site 1138871000784 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1138871000785 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1138871000786 Walker A/P-loop; other site 1138871000787 ATP binding site [chemical binding]; other site 1138871000788 Q-loop/lid; other site 1138871000789 ABC transporter signature motif; other site 1138871000790 Walker B; other site 1138871000791 D-loop; other site 1138871000792 H-loop/switch region; other site 1138871000793 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 1138871000794 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1138871000795 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1138871000796 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138871000797 catalytic residue [active] 1138871000798 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1138871000799 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1138871000800 NAD(P) binding site [chemical binding]; other site 1138871000801 eRF1 domain 3; Region: eRF1_3; pfam03465 1138871000802 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1138871000803 Beta-lactamase; Region: Beta-lactamase; pfam00144 1138871000804 enoyl-CoA hydratase; Provisional; Region: PRK06142 1138871000805 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138871000806 substrate binding site [chemical binding]; other site 1138871000807 oxyanion hole (OAH) forming residues; other site 1138871000808 trimer interface [polypeptide binding]; other site 1138871000809 TIGR03086 family protein; Region: TIGR03086 1138871000810 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1138871000811 GXWXG protein; Region: GXWXG; pfam14231 1138871000812 Domain of unknown function (DUF4334); Region: DUF4334; pfam14232 1138871000813 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1138871000814 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1138871000815 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138871000816 homodimer interface [polypeptide binding]; other site 1138871000817 catalytic residue [active] 1138871000818 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1138871000819 Phosphotransferase enzyme family; Region: APH; pfam01636 1138871000820 putative active site [active] 1138871000821 putative substrate binding site [chemical binding]; other site 1138871000822 ATP binding site [chemical binding]; other site 1138871000823 SnoaL-like domain; Region: SnoaL_2; pfam12680 1138871000824 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138871000825 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138871000826 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1138871000827 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138871000828 active site 1138871000829 phosphorylation site [posttranslational modification] 1138871000830 intermolecular recognition site; other site 1138871000831 dimerization interface [polypeptide binding]; other site 1138871000832 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1138871000833 DNA binding site [nucleotide binding] 1138871000834 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1138871000835 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1138871000836 dimerization interface [polypeptide binding]; other site 1138871000837 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1138871000838 dimer interface [polypeptide binding]; other site 1138871000839 phosphorylation site [posttranslational modification] 1138871000840 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138871000841 ATP binding site [chemical binding]; other site 1138871000842 Mg2+ binding site [ion binding]; other site 1138871000843 G-X-G motif; other site 1138871000844 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1138871000845 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 1138871000846 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1138871000847 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1138871000848 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1138871000849 NAD(P) binding site [chemical binding]; other site 1138871000850 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871000851 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871000852 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871000853 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871000854 active site 1138871000855 short chain dehydrogenase; Provisional; Region: PRK07035 1138871000856 classical (c) SDRs; Region: SDR_c; cd05233 1138871000857 NAD(P) binding site [chemical binding]; other site 1138871000858 active site 1138871000859 Phosphotransferase enzyme family; Region: APH; pfam01636 1138871000860 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1138871000861 putative active site [active] 1138871000862 putative substrate binding site [chemical binding]; other site 1138871000863 ATP binding site [chemical binding]; other site 1138871000864 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1138871000865 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1138871000866 catalytic core [active] 1138871000867 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1138871000868 putative active site [active] 1138871000869 putative substrate binding site [chemical binding]; other site 1138871000870 ATP binding site [chemical binding]; other site 1138871000871 Uncharacterized integral membrane protein [Function unknown]; Region: COG5416 1138871000872 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1138871000873 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1138871000874 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1138871000875 Walker A/P-loop; other site 1138871000876 ATP binding site [chemical binding]; other site 1138871000877 Q-loop/lid; other site 1138871000878 ABC transporter signature motif; other site 1138871000879 Walker B; other site 1138871000880 D-loop; other site 1138871000881 H-loop/switch region; other site 1138871000882 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1138871000883 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1138871000884 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 1138871000885 prephenate dehydrogenase; Validated; Region: PRK06545 1138871000886 prephenate dehydrogenase; Validated; Region: PRK08507 1138871000887 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 1138871000888 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1138871000889 nucleoside/Zn binding site; other site 1138871000890 dimer interface [polypeptide binding]; other site 1138871000891 catalytic motif [active] 1138871000892 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 1138871000893 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1138871000894 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 1138871000895 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467 1138871000896 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1138871000897 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138871000898 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1138871000899 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1138871000900 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138871000901 DNA-binding site [nucleotide binding]; DNA binding site 1138871000902 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1138871000903 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1138871000904 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1138871000905 active site 1138871000906 non-prolyl cis peptide bond; other site 1138871000907 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138871000908 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138871000909 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1138871000910 pyruvate carboxylase; Reviewed; Region: PRK12999 1138871000911 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1138871000912 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1138871000913 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1138871000914 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1138871000915 active site 1138871000916 catalytic residues [active] 1138871000917 metal binding site [ion binding]; metal-binding site 1138871000918 homodimer binding site [polypeptide binding]; other site 1138871000919 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1138871000920 carboxyltransferase (CT) interaction site; other site 1138871000921 biotinylation site [posttranslational modification]; other site 1138871000922 citrate synthase; Provisional; Region: PRK14033 1138871000923 Cold-active citrate synthase (CS) from an Antarctic bacterial strain DS2-3R (Ds)-like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or...; Region: DsCS_like; cd06111 1138871000924 dimer interface [polypeptide binding]; other site 1138871000925 active site 1138871000926 citrylCoA binding site [chemical binding]; other site 1138871000927 oxalacetate/citrate binding site [chemical binding]; other site 1138871000928 coenzyme A binding site [chemical binding]; other site 1138871000929 catalytic triad [active] 1138871000930 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1138871000931 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1138871000932 tetramer interface [polypeptide binding]; other site 1138871000933 active site 1138871000934 Mg2+/Mn2+ binding site [ion binding]; other site 1138871000935 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1138871000936 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1138871000937 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1138871000938 non-specific DNA binding site [nucleotide binding]; other site 1138871000939 salt bridge; other site 1138871000940 sequence-specific DNA binding site [nucleotide binding]; other site 1138871000941 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1138871000942 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1138871000943 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1138871000944 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1138871000945 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1138871000946 substrate binding site [chemical binding]; other site 1138871000947 ATP binding site [chemical binding]; other site 1138871000948 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 1138871000949 dimerization interface [polypeptide binding]; other site 1138871000950 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1138871000951 NAD binding site [chemical binding]; other site 1138871000952 ligand binding site [chemical binding]; other site 1138871000953 catalytic site [active] 1138871000954 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1138871000955 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871000956 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138871000957 classical (c) SDRs; Region: SDR_c; cd05233 1138871000958 NAD(P) binding site [chemical binding]; other site 1138871000959 active site 1138871000960 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1138871000961 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138871000962 active site 1138871000963 metal binding site [ion binding]; metal-binding site 1138871000964 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138871000965 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1138871000966 short chain dehydrogenase; Provisional; Region: PRK07856 1138871000967 classical (c) SDRs; Region: SDR_c; cd05233 1138871000968 NAD(P) binding site [chemical binding]; other site 1138871000969 active site 1138871000970 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138871000971 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1138871000972 Predicted NTP pyrophosphohydrolase [DNA replication, recombination, and repair / General function prediction only]; Region: COG4119 1138871000973 nudix motif; other site 1138871000974 haloalkane dehalogenase; Provisional; Region: PRK00870 1138871000975 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871000976 Cytochrome P450; Region: p450; cl12078 1138871000977 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138871000978 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138871000979 active site 1138871000980 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 1138871000981 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 1138871000982 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 1138871000983 active site 1138871000984 DNA binding site [nucleotide binding] 1138871000985 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 1138871000986 DNA binding site [nucleotide binding] 1138871000987 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 1138871000988 nucleotide binding site [chemical binding]; other site 1138871000989 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 1138871000990 Isochorismatase family; Region: Isochorismatase; pfam00857 1138871000991 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1138871000992 catalytic triad [active] 1138871000993 conserved cis-peptide bond; other site 1138871000994 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1138871000995 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871000996 Cytochrome P450; Region: p450; cl12078 1138871000997 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871000998 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871000999 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 1138871001000 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1138871001001 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871001002 NAD(P) binding site [chemical binding]; other site 1138871001003 active site 1138871001004 Cutinase; Region: Cutinase; pfam01083 1138871001005 CsbD-like; Region: CsbD; pfam05532 1138871001006 Beta-lactamase; Region: Beta-lactamase; pfam00144 1138871001007 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1138871001008 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138871001009 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1138871001010 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 1138871001011 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1138871001012 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138871001013 catalytic residue [active] 1138871001014 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1138871001015 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138871001016 Walker A motif; other site 1138871001017 ATP binding site [chemical binding]; other site 1138871001018 Walker B motif; other site 1138871001019 arginine finger; other site 1138871001020 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1138871001021 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1138871001022 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1138871001023 S-adenosylmethionine binding site [chemical binding]; other site 1138871001024 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1138871001025 FAD binding domain; Region: FAD_binding_4; pfam01565 1138871001026 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1138871001027 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1138871001028 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1138871001029 active site 1138871001030 metal binding site [ion binding]; metal-binding site 1138871001031 hypothetical protein; Validated; Region: PRK00153 1138871001032 recombination protein RecR; Reviewed; Region: recR; PRK00076 1138871001033 RecR protein; Region: RecR; pfam02132 1138871001034 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1138871001035 putative active site [active] 1138871001036 putative metal-binding site [ion binding]; other site 1138871001037 tetramer interface [polypeptide binding]; other site 1138871001038 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1138871001039 catalytic triad [active] 1138871001040 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1138871001041 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1138871001042 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1138871001043 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 1138871001044 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1138871001045 active site 1138871001046 catalytic site [active] 1138871001047 substrate binding site [chemical binding]; other site 1138871001048 2-isopropylmalate synthase; Validated; Region: PRK03739 1138871001049 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1138871001050 active site 1138871001051 catalytic residues [active] 1138871001052 metal binding site [ion binding]; metal-binding site 1138871001053 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1138871001054 aspartate kinase; Reviewed; Region: PRK06635 1138871001055 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1138871001056 putative nucleotide binding site [chemical binding]; other site 1138871001057 putative catalytic residues [active] 1138871001058 putative Mg ion binding site [ion binding]; other site 1138871001059 putative aspartate binding site [chemical binding]; other site 1138871001060 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1138871001061 putative allosteric regulatory site; other site 1138871001062 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1138871001063 putative allosteric regulatory residue; other site 1138871001064 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1138871001065 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1138871001066 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1138871001067 PknH-like extracellular domain; Region: PknH_C; pfam14032 1138871001068 ergothioneine biosynthesis glutamate--cysteine ligase EgtA; Region: EgtA_Cys_ligase; TIGR03444 1138871001069 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 1138871001070 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1138871001071 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 1138871001072 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1138871001073 putative active site [active] 1138871001074 putative dimer interface [polypeptide binding]; other site 1138871001075 Uncharacterized conserved protein [Function unknown]; Region: COG4301 1138871001076 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1138871001077 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1138871001078 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1138871001079 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138871001080 catalytic residue [active] 1138871001081 Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724 1138871001082 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871001083 S-adenosylmethionine binding site [chemical binding]; other site 1138871001084 glycerol kinase; Provisional; Region: glpK; PRK00047 1138871001085 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 1138871001086 N- and C-terminal domain interface [polypeptide binding]; other site 1138871001087 active site 1138871001088 MgATP binding site [chemical binding]; other site 1138871001089 catalytic site [active] 1138871001090 metal binding site [ion binding]; metal-binding site 1138871001091 putative homotetramer interface [polypeptide binding]; other site 1138871001092 glycerol binding site [chemical binding]; other site 1138871001093 homodimer interface [polypeptide binding]; other site 1138871001094 Predicted transcriptional regulators [Transcription]; Region: COG1695 1138871001095 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1138871001096 Predicted membrane protein/domain [Function unknown]; Region: COG1714 1138871001097 Uncharacterized membrane protein [Function unknown]; Region: SpoIIM; COG1300 1138871001098 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1138871001099 Protein of unknown function DUF58; Region: DUF58; pfam01882 1138871001100 MoxR-like ATPases [General function prediction only]; Region: COG0714 1138871001101 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138871001102 Walker A motif; other site 1138871001103 ATP binding site [chemical binding]; other site 1138871001104 Walker B motif; other site 1138871001105 arginine finger; other site 1138871001106 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1138871001107 Uncharacterized conserved protein [Function unknown]; Region: COG1610 1138871001108 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 1138871001109 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138871001110 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1138871001111 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1138871001112 proposed catalytic triad [active] 1138871001113 conserved cys residue [active] 1138871001114 putative methyltransferase; Provisional; Region: PRK14967 1138871001115 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871001116 S-adenosylmethionine binding site [chemical binding]; other site 1138871001117 Phosphoserine phosphatase RsbU, N-terminal domain; Region: RsbU_N; pfam08673 1138871001118 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1138871001119 PAS domain; Region: PAS_9; pfam13426 1138871001120 putative active site [active] 1138871001121 heme pocket [chemical binding]; other site 1138871001122 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1138871001123 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1138871001124 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1138871001125 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1138871001126 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1138871001127 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138871001128 ATP binding site [chemical binding]; other site 1138871001129 Mg2+ binding site [ion binding]; other site 1138871001130 G-X-G motif; other site 1138871001131 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1138871001132 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 1138871001133 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1138871001134 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1138871001135 anti sigma factor interaction site; other site 1138871001136 regulatory phosphorylation site [posttranslational modification]; other site 1138871001137 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1138871001138 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 1138871001139 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138871001140 motif II; other site 1138871001141 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1138871001142 Restriction endonuclease; Region: Mrr_cat; pfam04471 1138871001143 GAF domain; Region: GAF; cl17456 1138871001144 GAF domain; Region: GAF_2; pfam13185 1138871001145 ANTAR domain; Region: ANTAR; pfam03861 1138871001146 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1138871001147 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1138871001148 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138871001149 catalytic residue [active] 1138871001150 phosphodiesterase YaeI; Provisional; Region: PRK11340 1138871001151 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1138871001152 putative active site [active] 1138871001153 putative metal binding site [ion binding]; other site 1138871001154 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1138871001155 Transglycosylase; Region: Transgly; pfam00912 1138871001156 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1138871001157 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1138871001158 Transcription factor WhiB; Region: Whib; pfam02467 1138871001159 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1138871001160 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1138871001161 DTAP/Switch II; other site 1138871001162 Switch I; other site 1138871001163 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1138871001164 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1138871001165 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1138871001166 P loop; other site 1138871001167 Nucleotide binding site [chemical binding]; other site 1138871001168 DTAP/Switch II; other site 1138871001169 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1138871001170 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1138871001171 homotrimer interaction site [polypeptide binding]; other site 1138871001172 putative active site [active] 1138871001173 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1138871001174 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1138871001175 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1138871001176 ligand binding site [chemical binding]; other site 1138871001177 flexible hinge region; other site 1138871001178 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1138871001179 putative switch regulator; other site 1138871001180 non-specific DNA interactions [nucleotide binding]; other site 1138871001181 DNA binding site [nucleotide binding] 1138871001182 sequence specific DNA binding site [nucleotide binding]; other site 1138871001183 putative cAMP binding site [chemical binding]; other site 1138871001184 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1138871001185 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1138871001186 minor groove reading motif; other site 1138871001187 helix-hairpin-helix signature motif; other site 1138871001188 substrate binding pocket [chemical binding]; other site 1138871001189 active site 1138871001190 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1138871001191 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1138871001192 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1138871001193 catalytic residues [active] 1138871001194 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1138871001195 putative active site [active] 1138871001196 putative CoA binding site [chemical binding]; other site 1138871001197 nudix motif; other site 1138871001198 metal binding site [ion binding]; metal-binding site 1138871001199 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1138871001200 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1138871001201 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138871001202 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1138871001203 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1138871001204 acetyl-CoA synthetase; Provisional; Region: PRK00174 1138871001205 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1138871001206 active site 1138871001207 CoA binding site [chemical binding]; other site 1138871001208 acyl-activating enzyme (AAE) consensus motif; other site 1138871001209 AMP binding site [chemical binding]; other site 1138871001210 acetate binding site [chemical binding]; other site 1138871001211 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 1138871001212 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1138871001213 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1138871001214 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1138871001215 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138871001216 dimer interface [polypeptide binding]; other site 1138871001217 conserved gate region; other site 1138871001218 ABC-ATPase subunit interface; other site 1138871001219 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1138871001220 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138871001221 dimer interface [polypeptide binding]; other site 1138871001222 conserved gate region; other site 1138871001223 putative PBP binding loops; other site 1138871001224 ABC-ATPase subunit interface; other site 1138871001225 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1138871001226 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1138871001227 Walker A/P-loop; other site 1138871001228 ATP binding site [chemical binding]; other site 1138871001229 Q-loop/lid; other site 1138871001230 ABC transporter signature motif; other site 1138871001231 Walker B; other site 1138871001232 D-loop; other site 1138871001233 H-loop/switch region; other site 1138871001234 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1138871001235 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1138871001236 Walker A/P-loop; other site 1138871001237 ATP binding site [chemical binding]; other site 1138871001238 Q-loop/lid; other site 1138871001239 ABC transporter signature motif; other site 1138871001240 Walker B; other site 1138871001241 D-loop; other site 1138871001242 H-loop/switch region; other site 1138871001243 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1138871001244 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1138871001245 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138871001246 motif II; other site 1138871001247 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1138871001248 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1138871001249 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1138871001250 hexamer interface [polypeptide binding]; other site 1138871001251 Walker B motif; other site 1138871001252 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1138871001253 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 1138871001254 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1138871001255 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1138871001256 ATP binding site [chemical binding]; other site 1138871001257 putative Mg++ binding site [ion binding]; other site 1138871001258 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1138871001259 nucleotide binding region [chemical binding]; other site 1138871001260 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1138871001261 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1138871001262 DNA-binding site [nucleotide binding]; DNA binding site 1138871001263 RNA-binding motif; other site 1138871001264 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1138871001265 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1138871001266 active site 1138871001267 interdomain interaction site; other site 1138871001268 putative metal-binding site [ion binding]; other site 1138871001269 nucleotide binding site [chemical binding]; other site 1138871001270 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 1138871001271 domain I; other site 1138871001272 phosphate binding site [ion binding]; other site 1138871001273 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1138871001274 domain II; other site 1138871001275 domain III; other site 1138871001276 nucleotide binding site [chemical binding]; other site 1138871001277 DNA binding groove [nucleotide binding] 1138871001278 catalytic site [active] 1138871001279 domain IV; other site 1138871001280 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1138871001281 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1138871001282 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1138871001283 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1138871001284 dimerization interface [polypeptide binding]; other site 1138871001285 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1138871001286 cyclase homology domain; Region: CHD; cd07302 1138871001287 nucleotidyl binding site; other site 1138871001288 metal binding site [ion binding]; metal-binding site 1138871001289 dimer interface [polypeptide binding]; other site 1138871001290 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1138871001291 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1138871001292 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1138871001293 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871001294 NAD(P) binding site [chemical binding]; other site 1138871001295 active site 1138871001296 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1138871001297 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1138871001298 Ligand binding site; other site 1138871001299 Putative Catalytic site; other site 1138871001300 DXD motif; other site 1138871001301 Protein of unknown function (DUF475); Region: DUF475; pfam04332 1138871001302 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1138871001303 dimer interface [polypeptide binding]; other site 1138871001304 substrate binding site [chemical binding]; other site 1138871001305 metal binding sites [ion binding]; metal-binding site 1138871001306 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027 1138871001307 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1138871001308 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1138871001309 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 1138871001310 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1138871001311 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1138871001312 Ligand Binding Site [chemical binding]; other site 1138871001313 TilS substrate binding domain; Region: TilS; pfam09179 1138871001314 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1138871001315 active site 1138871001316 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1138871001317 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1138871001318 PE family; Region: PE; pfam00934 1138871001319 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871001320 PPE family; Region: PPE; pfam00823 1138871001321 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138871001322 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138871001323 active site 1138871001324 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1138871001325 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 1138871001326 putative NAD(P) binding site [chemical binding]; other site 1138871001327 catalytic Zn binding site [ion binding]; other site 1138871001328 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1138871001329 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1138871001330 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138871001331 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138871001332 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1138871001333 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138871001334 active site 1138871001335 metal binding site [ion binding]; metal-binding site 1138871001336 FtsH Extracellular; Region: FtsH_ext; pfam06480 1138871001337 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1138871001338 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138871001339 Walker A motif; other site 1138871001340 ATP binding site [chemical binding]; other site 1138871001341 Walker B motif; other site 1138871001342 arginine finger; other site 1138871001343 Peptidase family M41; Region: Peptidase_M41; pfam01434 1138871001344 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1138871001345 homodecamer interface [polypeptide binding]; other site 1138871001346 GTP cyclohydrolase I; Provisional; Region: PLN03044 1138871001347 active site 1138871001348 putative catalytic site residues [active] 1138871001349 zinc binding site [ion binding]; other site 1138871001350 GTP-CH-I/GFRP interaction surface; other site 1138871001351 dihydropteroate synthase; Region: DHPS; TIGR01496 1138871001352 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1138871001353 substrate binding pocket [chemical binding]; other site 1138871001354 dimer interface [polypeptide binding]; other site 1138871001355 inhibitor binding site; inhibition site 1138871001356 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1138871001357 homooctamer interface [polypeptide binding]; other site 1138871001358 active site 1138871001359 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1138871001360 catalytic center binding site [active] 1138871001361 ATP binding site [chemical binding]; other site 1138871001362 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1138871001363 Rossmann-like domain; Region: Rossmann-like; pfam10727 1138871001364 Uncharacterized conserved protein [Function unknown]; Region: COG5495 1138871001365 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 1138871001366 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1138871001367 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1138871001368 active site 1138871001369 ATP-binding site [chemical binding]; other site 1138871001370 pantoate-binding site; other site 1138871001371 HXXH motif; other site 1138871001372 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1138871001373 tetramerization interface [polypeptide binding]; other site 1138871001374 active site 1138871001375 pantothenate kinase; Reviewed; Region: PRK13318 1138871001376 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1138871001377 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1138871001378 dimer interface [polypeptide binding]; other site 1138871001379 putative anticodon binding site; other site 1138871001380 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1138871001381 motif 1; other site 1138871001382 dimer interface [polypeptide binding]; other site 1138871001383 active site 1138871001384 motif 2; other site 1138871001385 motif 3; other site 1138871001386 Lsr2; Region: Lsr2; pfam11774 1138871001387 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1138871001388 Clp amino terminal domain; Region: Clp_N; pfam02861 1138871001389 Clp amino terminal domain; Region: Clp_N; pfam02861 1138871001390 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138871001391 Walker A motif; other site 1138871001392 ATP binding site [chemical binding]; other site 1138871001393 Walker B motif; other site 1138871001394 arginine finger; other site 1138871001395 UvrB/uvrC motif; Region: UVR; pfam02151 1138871001396 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138871001397 Walker A motif; other site 1138871001398 ATP binding site [chemical binding]; other site 1138871001399 Walker B motif; other site 1138871001400 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1138871001401 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 1138871001402 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1138871001403 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1138871001404 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138871001405 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1138871001406 catalytic site [active] 1138871001407 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1138871001408 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1138871001409 minor groove reading motif; other site 1138871001410 helix-hairpin-helix signature motif; other site 1138871001411 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 1138871001412 active site clefts [active] 1138871001413 zinc binding site [ion binding]; other site 1138871001414 dimer interface [polypeptide binding]; other site 1138871001415 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1138871001416 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1138871001417 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1138871001418 DNA repair protein RadA; Provisional; Region: PRK11823 1138871001419 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1138871001420 Walker A motif/ATP binding site; other site 1138871001421 ATP binding site [chemical binding]; other site 1138871001422 Walker B motif; other site 1138871001423 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1138871001424 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 1138871001425 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1138871001426 substrate binding site; other site 1138871001427 dimer interface; other site 1138871001428 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1138871001429 homotrimer interaction site [polypeptide binding]; other site 1138871001430 zinc binding site [ion binding]; other site 1138871001431 CDP-binding sites; other site 1138871001432 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1138871001433 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1138871001434 active site 1138871001435 HIGH motif; other site 1138871001436 nucleotide binding site [chemical binding]; other site 1138871001437 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1138871001438 KMSKS motif; other site 1138871001439 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1138871001440 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1138871001441 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1138871001442 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1138871001443 Glycerophosphodiester phosphodiesterase domain of putative Silicibacter pomeroyi glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_SpGDE_like; cd08567 1138871001444 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1138871001445 active site 1138871001446 catalytic site [active] 1138871001447 metal binding site [ion binding]; metal-binding site 1138871001448 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1138871001449 transmembrane helices; other site 1138871001450 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1138871001451 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1138871001452 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1138871001453 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1138871001454 putative active site [active] 1138871001455 PknH-like extracellular domain; Region: PknH_C; pfam14032 1138871001456 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1138871001457 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1138871001458 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138871001459 Walker A/P-loop; other site 1138871001460 ATP binding site [chemical binding]; other site 1138871001461 Q-loop/lid; other site 1138871001462 ABC transporter signature motif; other site 1138871001463 Walker B; other site 1138871001464 D-loop; other site 1138871001465 H-loop/switch region; other site 1138871001466 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1138871001467 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1138871001468 intersubunit interface [polypeptide binding]; other site 1138871001469 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1138871001470 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1138871001471 DNA binding site [nucleotide binding] 1138871001472 domain linker motif; other site 1138871001473 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_3; cd06279 1138871001474 putative dimerization interface [polypeptide binding]; other site 1138871001475 putative ligand binding site [chemical binding]; other site 1138871001476 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871001477 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871001478 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871001479 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138871001480 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871001481 active site 1138871001482 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871001483 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871001484 active site 1138871001485 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1138871001486 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871001487 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 1138871001488 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1138871001489 putative NAD(P) binding site [chemical binding]; other site 1138871001490 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1138871001491 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1138871001492 FAD binding pocket [chemical binding]; other site 1138871001493 FAD binding motif [chemical binding]; other site 1138871001494 phosphate binding motif [ion binding]; other site 1138871001495 beta-alpha-beta structure motif; other site 1138871001496 NAD(p) ribose binding residues [chemical binding]; other site 1138871001497 NAD binding pocket [chemical binding]; other site 1138871001498 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1138871001499 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1138871001500 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1138871001501 catalytic loop [active] 1138871001502 iron binding site [ion binding]; other site 1138871001503 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871001504 Naphthocyclinone hydroxylase; Region: NcnH; cd01159 1138871001505 Flavin binding site [chemical binding]; other site 1138871001506 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 1138871001507 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1138871001508 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 1138871001509 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 1138871001510 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 1138871001511 active site 1138871001512 Fe binding site [ion binding]; other site 1138871001513 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1138871001514 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 1138871001515 aspartate aminotransferase; Provisional; Region: PRK05764 1138871001516 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1138871001517 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138871001518 homodimer interface [polypeptide binding]; other site 1138871001519 catalytic residue [active] 1138871001520 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138871001521 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871001522 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871001523 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1138871001524 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138871001525 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871001526 active site 1138871001527 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871001528 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871001529 active site 1138871001530 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1138871001531 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871001532 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1138871001533 acyl-activating enzyme (AAE) consensus motif; other site 1138871001534 acyl-activating enzyme (AAE) consensus motif; other site 1138871001535 putative AMP binding site [chemical binding]; other site 1138871001536 putative active site [active] 1138871001537 putative CoA binding site [chemical binding]; other site 1138871001538 CoA binding site [chemical binding]; other site 1138871001539 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871001540 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871001541 active site 1138871001542 short chain dehydrogenase; Provisional; Region: PRK07831 1138871001543 classical (c) SDRs; Region: SDR_c; cd05233 1138871001544 NAD(P) binding site [chemical binding]; other site 1138871001545 active site 1138871001546 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871001547 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871001548 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1138871001549 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1138871001550 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138871001551 dimer interface [polypeptide binding]; other site 1138871001552 active site 1138871001553 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1138871001554 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1138871001555 putative active site [active] 1138871001556 Nitronate monooxygenase; Region: NMO; pfam03060 1138871001557 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1138871001558 FMN binding site [chemical binding]; other site 1138871001559 substrate binding site [chemical binding]; other site 1138871001560 putative catalytic residue [active] 1138871001561 Coenzyme A transferase; Region: CoA_trans; cl17247 1138871001562 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1138871001563 enoyl-CoA hydratase; Provisional; Region: PRK06495 1138871001564 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138871001565 substrate binding site [chemical binding]; other site 1138871001566 oxyanion hole (OAH) forming residues; other site 1138871001567 trimer interface [polypeptide binding]; other site 1138871001568 short chain dehydrogenase; Provisional; Region: PRK07856 1138871001569 classical (c) SDRs; Region: SDR_c; cd05233 1138871001570 NAD(P) binding site [chemical binding]; other site 1138871001571 active site 1138871001572 short chain dehydrogenase; Provisional; Region: PRK07791 1138871001573 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871001574 NAD(P) binding site [chemical binding]; other site 1138871001575 active site 1138871001576 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1138871001577 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1138871001578 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 1138871001579 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138871001580 dimer interface [polypeptide binding]; other site 1138871001581 active site 1138871001582 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871001583 Cytochrome P450; Region: p450; cl12078 1138871001584 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871001585 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138871001586 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871001587 active site 1138871001588 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871001589 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871001590 active site 1138871001591 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1138871001592 active site 1138871001593 catalytic site [active] 1138871001594 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1138871001595 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138871001596 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 1138871001597 putative active site [active] 1138871001598 putative catalytic site [active] 1138871001599 lipid-transfer protein; Provisional; Region: PRK07855 1138871001600 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138871001601 active site 1138871001602 enoyl-CoA hydratase; Region: PLN02864 1138871001603 Metal-binding domain of MaoC dehydratase; Region: zf-MaoC; pfam13452 1138871001604 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 1138871001605 dimer interaction site [polypeptide binding]; other site 1138871001606 substrate-binding tunnel; other site 1138871001607 active site 1138871001608 catalytic site [active] 1138871001609 substrate binding site [chemical binding]; other site 1138871001610 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 1138871001611 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1138871001612 2-keto-4-pentenoate hydratase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3971 1138871001613 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1138871001614 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1138871001615 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1138871001616 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1138871001617 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1138871001618 active site 1138871001619 catalytic residues [active] 1138871001620 metal binding site [ion binding]; metal-binding site 1138871001621 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1138871001622 short chain dehydrogenase; Provisional; Region: PRK07890 1138871001623 classical (c) SDRs; Region: SDR_c; cd05233 1138871001624 NAD(P) binding site [chemical binding]; other site 1138871001625 active site 1138871001626 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 1138871001627 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1138871001628 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1138871001629 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 1138871001630 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1138871001631 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1138871001632 trimer interface [polypeptide binding]; other site 1138871001633 putative metal binding site [ion binding]; other site 1138871001634 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1138871001635 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 1138871001636 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138871001637 active site 1138871001638 lipid-transfer protein; Provisional; Region: PRK07937 1138871001639 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138871001640 active site 1138871001641 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1138871001642 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1138871001643 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138871001644 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138871001645 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1138871001646 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 1138871001647 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871001648 Cytochrome P450; Region: p450; cl12078 1138871001649 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1138871001650 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1138871001651 putative active site [active] 1138871001652 enoyl-CoA hydratase; Provisional; Region: PRK07799 1138871001653 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138871001654 substrate binding site [chemical binding]; other site 1138871001655 oxyanion hole (OAH) forming residues; other site 1138871001656 trimer interface [polypeptide binding]; other site 1138871001657 acyl-CoA synthetase; Validated; Region: PRK07798 1138871001658 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871001659 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 1138871001660 acyl-activating enzyme (AAE) consensus motif; other site 1138871001661 acyl-activating enzyme (AAE) consensus motif; other site 1138871001662 putative AMP binding site [chemical binding]; other site 1138871001663 putative active site [active] 1138871001664 putative CoA binding site [chemical binding]; other site 1138871001665 Fructosamine kinase; Region: Fructosamin_kin; cl17579 1138871001666 Phosphotransferase enzyme family; Region: APH; pfam01636 1138871001667 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1138871001668 hypothetical protein; Validated; Region: PRK07586 1138871001669 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1138871001670 PYR/PP interface [polypeptide binding]; other site 1138871001671 dimer interface [polypeptide binding]; other site 1138871001672 TPP binding site [chemical binding]; other site 1138871001673 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 1138871001674 TPP-binding site [chemical binding]; other site 1138871001675 dimer interface [polypeptide binding]; other site 1138871001676 acyl-CoA synthetase; Validated; Region: PRK07867 1138871001677 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 1138871001678 acyl-activating enzyme (AAE) consensus motif; other site 1138871001679 putative AMP binding site [chemical binding]; other site 1138871001680 putative active site [active] 1138871001681 putative CoA binding site [chemical binding]; other site 1138871001682 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871001683 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1138871001684 active site 1138871001685 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871001686 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1138871001687 FAD binding site [chemical binding]; other site 1138871001688 substrate binding site [chemical binding]; other site 1138871001689 catalytic base [active] 1138871001690 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1138871001691 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1138871001692 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 1138871001693 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871001694 NAD(P) binding site [chemical binding]; other site 1138871001695 active site 1138871001696 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1138871001697 Permease; Region: Permease; pfam02405 1138871001698 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1138871001699 Permease; Region: Permease; pfam02405 1138871001700 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138871001701 mce related protein; Region: MCE; pfam02470 1138871001702 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1138871001703 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138871001704 mce related protein; Region: MCE; pfam02470 1138871001705 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1138871001706 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138871001707 mce related protein; Region: MCE; pfam02470 1138871001708 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 1138871001709 mce related protein; Region: MCE; pfam02470 1138871001710 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138871001711 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138871001712 mce related protein; Region: MCE; pfam02470 1138871001713 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138871001714 mce related protein; Region: MCE; pfam02470 1138871001715 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 1138871001716 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1138871001717 active site 1138871001718 homotetramer interface [polypeptide binding]; other site 1138871001719 enoyl-CoA hydratase; Provisional; Region: PRK08290 1138871001720 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138871001721 substrate binding site [chemical binding]; other site 1138871001722 oxyanion hole (OAH) forming residues; other site 1138871001723 trimer interface [polypeptide binding]; other site 1138871001724 short chain dehydrogenase; Provisional; Region: PRK05875 1138871001725 classical (c) SDRs; Region: SDR_c; cd05233 1138871001726 NAD(P) binding site [chemical binding]; other site 1138871001727 active site 1138871001728 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138871001729 classical (c) SDRs; Region: SDR_c; cd05233 1138871001730 NAD(P) binding site [chemical binding]; other site 1138871001731 active site 1138871001732 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1138871001733 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1138871001734 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1138871001735 Amidase; Region: Amidase; cl11426 1138871001736 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138871001737 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1138871001738 Peptidase family S64; Region: Peptidase_S64; pfam08192 1138871001739 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1138871001740 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1138871001741 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1138871001742 catalytic residue [active] 1138871001743 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138871001744 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1138871001745 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138871001746 active site 1138871001747 phosphorylation site [posttranslational modification] 1138871001748 intermolecular recognition site; other site 1138871001749 dimerization interface [polypeptide binding]; other site 1138871001750 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1138871001751 DNA binding site [nucleotide binding] 1138871001752 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1138871001753 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1138871001754 dimerization interface [polypeptide binding]; other site 1138871001755 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1138871001756 dimer interface [polypeptide binding]; other site 1138871001757 phosphorylation site [posttranslational modification] 1138871001758 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138871001759 ATP binding site [chemical binding]; other site 1138871001760 Mg2+ binding site [ion binding]; other site 1138871001761 G-X-G motif; other site 1138871001762 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1138871001763 nucleotide binding site/active site [active] 1138871001764 HIT family signature motif; other site 1138871001765 catalytic residue [active] 1138871001766 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 1138871001767 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1138871001768 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1138871001769 NAD binding site [chemical binding]; other site 1138871001770 catalytic Zn binding site [ion binding]; other site 1138871001771 substrate binding site [chemical binding]; other site 1138871001772 structural Zn binding site [ion binding]; other site 1138871001773 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1138871001774 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1138871001775 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871001776 Cytochrome P450; Region: p450; cl12078 1138871001777 short chain dehydrogenase; Provisional; Region: PRK07775 1138871001778 classical (c) SDRs; Region: SDR_c; cd05233 1138871001779 NAD(P) binding site [chemical binding]; other site 1138871001780 active site 1138871001781 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871001782 Cytochrome P450; Region: p450; cl12078 1138871001783 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871001784 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 1138871001785 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1138871001786 NAD binding site [chemical binding]; other site 1138871001787 catalytic residues [active] 1138871001788 short chain dehydrogenase; Provisional; Region: PRK07774 1138871001789 classical (c) SDRs; Region: SDR_c; cd05233 1138871001790 NAD(P) binding site [chemical binding]; other site 1138871001791 active site 1138871001792 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1138871001793 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1138871001794 Domain of unknown function (DUF1841); Region: DUF1841; pfam08897 1138871001795 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1138871001796 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1138871001797 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1138871001798 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1138871001799 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1138871001800 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1138871001801 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1138871001802 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1138871001803 Predicted nuclease (RNAse H fold) [General function prediction only]; Region: COG4328 1138871001804 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1138871001805 Lyase; Region: Lyase_1; pfam00206 1138871001806 tetramer interface [polypeptide binding]; other site 1138871001807 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871001808 Cytochrome P450; Region: p450; cl12078 1138871001809 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_1; cd09319 1138871001810 gating phenylalanine in ion channel; other site 1138871001811 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1138871001812 ATP binding site [chemical binding]; other site 1138871001813 active site 1138871001814 substrate binding site [chemical binding]; other site 1138871001815 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1138871001816 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138871001817 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1138871001818 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138871001819 putative substrate translocation pore; other site 1138871001820 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138871001821 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1138871001822 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138871001823 putative substrate translocation pore; other site 1138871001824 Predicted deacetylase [General function prediction only]; Region: COG3233 1138871001825 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u10; cd11374 1138871001826 putative active site [active] 1138871001827 putative Zn binding site [ion binding]; other site 1138871001828 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1138871001829 FAD binding domain; Region: FAD_binding_2; pfam00890 1138871001830 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1138871001831 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 1138871001832 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1138871001833 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1138871001834 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1138871001835 putative active site [active] 1138871001836 catalytic triad [active] 1138871001837 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138871001838 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1138871001839 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1138871001840 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1138871001841 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1138871001842 putative acyl-acceptor binding pocket; other site 1138871001843 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1138871001844 extended (e) SDRs; Region: SDR_e; cd08946 1138871001845 NAD(P) binding site [chemical binding]; other site 1138871001846 active site 1138871001847 substrate binding site [chemical binding]; other site 1138871001848 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1138871001849 Cupin domain; Region: Cupin_2; cl17218 1138871001850 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1138871001851 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138871001852 motif II; other site 1138871001853 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 1138871001854 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1138871001855 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138871001856 Domain of unknown function (DUF427); Region: DUF427; cl00998 1138871001857 Domain of unknown function (DUF427); Region: DUF427; cl00998 1138871001858 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 1138871001859 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1138871001860 putative NAD(P) binding site [chemical binding]; other site 1138871001861 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871001862 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871001863 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871001864 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138871001865 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138871001866 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1138871001867 MOSC domain; Region: MOSC; pfam03473 1138871001868 3-alpha domain; Region: 3-alpha; pfam03475 1138871001869 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1138871001870 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1138871001871 FAD binding pocket [chemical binding]; other site 1138871001872 FAD binding motif [chemical binding]; other site 1138871001873 phosphate binding motif [ion binding]; other site 1138871001874 beta-alpha-beta structure motif; other site 1138871001875 NAD binding pocket [chemical binding]; other site 1138871001876 Encapsulating protein for peroxidase; Region: Linocin_M18; cl17804 1138871001877 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1138871001878 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1138871001879 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1138871001880 active site 1138871001881 metal binding site [ion binding]; metal-binding site 1138871001882 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871001883 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871001884 Ecdysteroid kinase; Region: EcKinase; cl17738 1138871001885 Phosphotransferase enzyme family; Region: APH; pfam01636 1138871001886 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1138871001887 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1138871001888 dimerization interface [polypeptide binding]; other site 1138871001889 ATP binding site [chemical binding]; other site 1138871001890 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1138871001891 dimerization interface [polypeptide binding]; other site 1138871001892 ATP binding site [chemical binding]; other site 1138871001893 CAAX protease self-immunity; Region: Abi; pfam02517 1138871001894 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138871001895 mce related protein; Region: MCE; pfam02470 1138871001896 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1138871001897 amidophosphoribosyltransferase; Provisional; Region: PRK07847 1138871001898 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1138871001899 active site 1138871001900 tetramer interface [polypeptide binding]; other site 1138871001901 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1138871001902 active site 1138871001903 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1138871001904 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1138871001905 dimerization interface [polypeptide binding]; other site 1138871001906 putative ATP binding site [chemical binding]; other site 1138871001907 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 1138871001908 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 1138871001909 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1138871001910 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1138871001911 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1138871001912 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1138871001913 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138871001914 catalytic residue [active] 1138871001915 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1138871001916 heme-binding site [chemical binding]; other site 1138871001917 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 1138871001918 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1138871001919 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1138871001920 active site residue [active] 1138871001921 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1138871001922 active site residue [active] 1138871001923 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 1138871001924 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1138871001925 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1138871001926 catalytic residues [active] 1138871001927 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1138871001928 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1138871001929 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1138871001930 DNA binding site [nucleotide binding] 1138871001931 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 1138871001932 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1138871001933 Coenzyme A binding pocket [chemical binding]; other site 1138871001934 PBP superfamily domain; Region: PBP_like_2; cl17296 1138871001935 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138871001936 dimer interface [polypeptide binding]; other site 1138871001937 conserved gate region; other site 1138871001938 putative PBP binding loops; other site 1138871001939 ABC-ATPase subunit interface; other site 1138871001940 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 1138871001941 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138871001942 dimer interface [polypeptide binding]; other site 1138871001943 conserved gate region; other site 1138871001944 putative PBP binding loops; other site 1138871001945 ABC-ATPase subunit interface; other site 1138871001946 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1138871001947 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1138871001948 Walker A/P-loop; other site 1138871001949 ATP binding site [chemical binding]; other site 1138871001950 Q-loop/lid; other site 1138871001951 ABC transporter signature motif; other site 1138871001952 Walker B; other site 1138871001953 D-loop; other site 1138871001954 H-loop/switch region; other site 1138871001955 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1138871001956 PhoU domain; Region: PhoU; pfam01895 1138871001957 PhoU domain; Region: PhoU; pfam01895 1138871001958 cell envelope-related function transcriptional attenuator common domain; Region: lytR_cpsA_psr; TIGR00350 1138871001959 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1138871001960 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1138871001961 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1138871001962 FMN binding site [chemical binding]; other site 1138871001963 active site 1138871001964 catalytic residues [active] 1138871001965 substrate binding site [chemical binding]; other site 1138871001966 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 1138871001967 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 1138871001968 homodimer interface [polypeptide binding]; other site 1138871001969 putative substrate binding pocket [chemical binding]; other site 1138871001970 diiron center [ion binding]; other site 1138871001971 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871001972 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1138871001973 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1138871001974 dimerization interface [polypeptide binding]; other site 1138871001975 putative DNA binding site [nucleotide binding]; other site 1138871001976 putative Zn2+ binding site [ion binding]; other site 1138871001977 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1138871001978 nucleoside/Zn binding site; other site 1138871001979 dimer interface [polypeptide binding]; other site 1138871001980 catalytic motif [active] 1138871001981 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138871001982 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138871001983 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 1138871001984 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1138871001985 active site 1138871001986 DNA binding site [nucleotide binding] 1138871001987 Int/Topo IB signature motif; other site 1138871001988 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138871001989 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1138871001990 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138871001991 DNA-binding site [nucleotide binding]; DNA binding site 1138871001992 UTRA domain; Region: UTRA; pfam07702 1138871001993 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138871001994 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138871001995 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1138871001996 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 1138871001997 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 1138871001998 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871001999 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871002000 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871002001 Cytochrome P450; Region: p450; cl12078 1138871002002 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1138871002003 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871002004 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1138871002005 classical (c) SDRs; Region: SDR_c; cd05233 1138871002006 NAD(P) binding site [chemical binding]; other site 1138871002007 active site 1138871002008 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871002009 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871002010 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871002011 Cytochrome P450; Region: p450; cl12078 1138871002012 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1138871002013 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138871002014 DNA-binding site [nucleotide binding]; DNA binding site 1138871002015 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1138871002016 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138871002017 homodimer interface [polypeptide binding]; other site 1138871002018 catalytic residue [active] 1138871002019 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138871002020 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1138871002021 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1138871002022 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1138871002023 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871002024 S-adenosylmethionine binding site [chemical binding]; other site 1138871002025 short chain dehydrogenase; Provisional; Region: PRK08278 1138871002026 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871002027 NAD(P) binding site [chemical binding]; other site 1138871002028 active site 1138871002029 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 1138871002030 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1138871002031 B12 binding site [chemical binding]; other site 1138871002032 cobalt ligand [ion binding]; other site 1138871002033 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 1138871002034 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138871002035 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138871002036 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138871002037 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1138871002038 SnoaL-like domain; Region: SnoaL_3; pfam13474 1138871002039 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138871002040 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1138871002041 catalytic loop [active] 1138871002042 iron binding site [ion binding]; other site 1138871002043 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1138871002044 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871002045 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871002046 acyl-activating enzyme (AAE) consensus motif; other site 1138871002047 acyl-activating enzyme (AAE) consensus motif; other site 1138871002048 AMP binding site [chemical binding]; other site 1138871002049 active site 1138871002050 CoA binding site [chemical binding]; other site 1138871002051 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871002052 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871002053 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871002054 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871002055 active site 1138871002056 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138871002057 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138871002058 substrate binding site [chemical binding]; other site 1138871002059 oxyanion hole (OAH) forming residues; other site 1138871002060 trimer interface [polypeptide binding]; other site 1138871002061 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 1138871002062 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 1138871002063 putative acyltransferase; Provisional; Region: PRK05790 1138871002064 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138871002065 dimer interface [polypeptide binding]; other site 1138871002066 active site 1138871002067 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 1138871002068 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1138871002069 Walker A; other site 1138871002070 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 1138871002071 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1138871002072 TPP-binding site [chemical binding]; other site 1138871002073 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1138871002074 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138871002075 active site 1138871002076 phosphorylation site [posttranslational modification] 1138871002077 intermolecular recognition site; other site 1138871002078 dimerization interface [polypeptide binding]; other site 1138871002079 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1138871002080 DNA binding residues [nucleotide binding] 1138871002081 dimerization interface [polypeptide binding]; other site 1138871002082 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1138871002083 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138871002084 ATP binding site [chemical binding]; other site 1138871002085 Mg2+ binding site [ion binding]; other site 1138871002086 G-X-G motif; other site 1138871002087 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1138871002088 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1138871002089 conserved cys residue [active] 1138871002090 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 1138871002091 Predicted oxidoreductase [General function prediction only]; Region: COG3573 1138871002092 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1138871002093 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1138871002094 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138871002095 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138871002096 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 1138871002097 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1138871002098 3-(2,3-dihydroxyphenyl)propionate dioxygenase; Provisional; Region: mhpB; PRK13370 1138871002099 active site 1138871002100 metal binding site [ion binding]; metal-binding site 1138871002101 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12835 1138871002102 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138871002103 Predicted oxidoreductase [General function prediction only]; Region: COG3573 1138871002104 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1138871002105 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1138871002106 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871002107 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138871002108 NAD(P) binding site [chemical binding]; other site 1138871002109 3-alpha-hydroxysteroid dehydrogenase; Provisional; Region: PRK12428 1138871002110 active site 1138871002111 Putative cyclase; Region: Cyclase; pfam04199 1138871002112 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138871002113 TAP-like protein; Region: Abhydrolase_4; pfam08386 1138871002114 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1138871002115 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1138871002116 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1138871002117 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1138871002118 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1138871002119 short chain dehydrogenase; Provisional; Region: PRK06500 1138871002120 classical (c) SDRs; Region: SDR_c; cd05233 1138871002121 NAD(P) binding site [chemical binding]; other site 1138871002122 active site 1138871002123 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1138871002124 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871002125 NAD(P) binding site [chemical binding]; other site 1138871002126 active site 1138871002127 AAA ATPase domain; Region: AAA_16; pfam13191 1138871002128 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1138871002129 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1138871002130 DNA binding residues [nucleotide binding] 1138871002131 dimerization interface [polypeptide binding]; other site 1138871002132 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1138871002133 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871002134 NAD(P) binding site [chemical binding]; other site 1138871002135 active site 1138871002136 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1138871002137 active site 1138871002138 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 1138871002139 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 1138871002140 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 1138871002141 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1138871002142 putative ADP-binding pocket [chemical binding]; other site 1138871002143 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1138871002144 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871002145 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871002146 Cytochrome P450; Region: p450; cl12078 1138871002147 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871002148 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138871002149 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1138871002150 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1138871002151 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1138871002152 active site 1138871002153 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1138871002154 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1138871002155 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1138871002156 active site 1138871002157 enoyl-CoA hydratase; Provisional; Region: PRK12478 1138871002158 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138871002159 substrate binding site [chemical binding]; other site 1138871002160 oxyanion hole (OAH) forming residues; other site 1138871002161 trimer interface [polypeptide binding]; other site 1138871002162 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138871002163 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138871002164 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138871002165 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138871002166 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1138871002167 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871002168 NAD(P) binding site [chemical binding]; other site 1138871002169 active site 1138871002170 short chain dehydrogenase; Provisional; Region: PRK05876 1138871002171 classical (c) SDRs; Region: SDR_c; cd05233 1138871002172 NAD(P) binding site [chemical binding]; other site 1138871002173 active site 1138871002174 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1138871002175 classical (c) SDRs; Region: SDR_c; cd05233 1138871002176 NAD(P) binding site [chemical binding]; other site 1138871002177 active site 1138871002178 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871002179 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871002180 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871002181 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871002182 active site 1138871002183 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871002184 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871002185 active site 1138871002186 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871002187 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871002188 active site 1138871002189 SnoaL-like domain; Region: SnoaL_4; pfam13577 1138871002190 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1138871002191 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138871002192 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1138871002193 active site 1138871002194 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1138871002195 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1138871002196 [2Fe-2S] cluster binding site [ion binding]; other site 1138871002197 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 1138871002198 alpha subunit interface [polypeptide binding]; other site 1138871002199 active site 1138871002200 substrate binding site [chemical binding]; other site 1138871002201 Fe binding site [ion binding]; other site 1138871002202 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1138871002203 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138871002204 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871002205 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871002206 active site 1138871002207 enoyl-CoA hydratase; Provisional; Region: PRK06688 1138871002208 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138871002209 substrate binding site [chemical binding]; other site 1138871002210 oxyanion hole (OAH) forming residues; other site 1138871002211 trimer interface [polypeptide binding]; other site 1138871002212 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1138871002213 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138871002214 dimer interface [polypeptide binding]; other site 1138871002215 active site 1138871002216 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871002217 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871002218 Cytochrome P450; Region: p450; cl12078 1138871002219 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1138871002220 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 1138871002221 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1138871002222 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1138871002223 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871002224 Cytochrome P450; Region: p450; cl12078 1138871002225 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1138871002226 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1138871002227 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1138871002228 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 1138871002229 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138871002230 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1138871002231 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138871002232 lipid-transfer protein; Provisional; Region: PRK07855 1138871002233 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138871002234 active site 1138871002235 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1138871002236 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871002237 NAD(P) binding site [chemical binding]; other site 1138871002238 active site 1138871002239 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 1138871002240 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138871002241 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138871002242 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871002243 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871002244 active site 1138871002245 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 1138871002246 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1138871002247 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138871002248 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146 1138871002249 iron-sulfur cluster [ion binding]; other site 1138871002250 [2Fe-2S] cluster binding site [ion binding]; other site 1138871002251 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138871002252 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138871002253 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1138871002254 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1138871002255 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1138871002256 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871002257 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138871002258 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871002259 active site 1138871002260 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871002261 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871002262 active site 1138871002263 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1138871002264 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871002265 Cytochrome P450; Region: p450; cl12078 1138871002266 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 1138871002267 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138871002268 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871002269 NAD(P) binding site [chemical binding]; other site 1138871002270 active site 1138871002271 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 1138871002272 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1138871002273 NAD binding site [chemical binding]; other site 1138871002274 catalytic residues [active] 1138871002275 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138871002276 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138871002277 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1138871002278 Permease; Region: Permease; pfam02405 1138871002279 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1138871002280 Permease; Region: Permease; pfam02405 1138871002281 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138871002282 mce related protein; Region: MCE; pfam02470 1138871002283 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1138871002284 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138871002285 mce related protein; Region: MCE; pfam02470 1138871002286 mce related protein; Region: MCE; pfam02470 1138871002287 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1138871002288 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138871002289 mce related protein; Region: MCE; pfam02470 1138871002290 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138871002291 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1138871002292 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138871002293 mce related protein; Region: MCE; pfam02470 1138871002294 Homeodomain-like domain; Region: HTH_23; pfam13384 1138871002295 Winged helix-turn helix; Region: HTH_29; pfam13551 1138871002296 Homeodomain-like domain; Region: HTH_32; pfam13565 1138871002297 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1138871002298 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1138871002299 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871002300 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1138871002301 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1138871002302 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1138871002303 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 1138871002304 Subunit I/III interface [polypeptide binding]; other site 1138871002305 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871002306 Cytochrome P450; Region: p450; cl12078 1138871002307 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871002308 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871002309 enoyl-CoA hydratase; Provisional; Region: PRK06688 1138871002310 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138871002311 substrate binding site [chemical binding]; other site 1138871002312 oxyanion hole (OAH) forming residues; other site 1138871002313 trimer interface [polypeptide binding]; other site 1138871002314 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1138871002315 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138871002316 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 1138871002317 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871002318 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1138871002319 acyl-activating enzyme (AAE) consensus motif; other site 1138871002320 acyl-activating enzyme (AAE) consensus motif; other site 1138871002321 putative AMP binding site [chemical binding]; other site 1138871002322 putative active site [active] 1138871002323 putative CoA binding site [chemical binding]; other site 1138871002324 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 1138871002325 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 1138871002326 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1138871002327 dimer interface [polypeptide binding]; other site 1138871002328 PYR/PP interface [polypeptide binding]; other site 1138871002329 TPP binding site [chemical binding]; other site 1138871002330 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1138871002331 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1138871002332 TPP-binding site [chemical binding]; other site 1138871002333 dimer interface [polypeptide binding]; other site 1138871002334 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1138871002335 putative hydrophobic ligand binding site [chemical binding]; other site 1138871002336 Integrase core domain; Region: rve; pfam00665 1138871002337 Integrase core domain; Region: rve_3; pfam13683 1138871002338 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1138871002339 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138871002340 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138871002341 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1138871002342 putative hydrophobic ligand binding site [chemical binding]; other site 1138871002343 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1138871002344 putative hydrophobic ligand binding site [chemical binding]; other site 1138871002345 aminotransferase; Validated; Region: PRK07777 1138871002346 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1138871002347 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138871002348 homodimer interface [polypeptide binding]; other site 1138871002349 catalytic residue [active] 1138871002350 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 1138871002351 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138871002352 dimer interface [polypeptide binding]; other site 1138871002353 active site 1138871002354 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138871002355 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138871002356 substrate binding site [chemical binding]; other site 1138871002357 oxyanion hole (OAH) forming residues; other site 1138871002358 trimer interface [polypeptide binding]; other site 1138871002359 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1138871002360 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1138871002361 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1138871002362 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871002363 S-adenosylmethionine binding site [chemical binding]; other site 1138871002364 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1138871002365 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 1138871002366 hypothetical protein; Provisional; Region: PRK07588 1138871002367 hypothetical protein; Provisional; Region: PRK07236 1138871002368 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871002369 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871002370 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138871002371 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1138871002372 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 1138871002373 Cupin; Region: Cupin_6; pfam12852 1138871002374 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1138871002375 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1138871002376 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1138871002377 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1138871002378 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138871002379 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 1138871002380 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138871002381 active site 1138871002382 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1138871002383 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1138871002384 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1138871002385 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1138871002386 ATP binding site [chemical binding]; other site 1138871002387 putative Mg++ binding site [ion binding]; other site 1138871002388 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1138871002389 nucleotide binding region [chemical binding]; other site 1138871002390 ATP-binding site [chemical binding]; other site 1138871002391 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1138871002392 WYL domain; Region: WYL; pfam13280 1138871002393 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1138871002394 trimer interface [polypeptide binding]; other site 1138871002395 dimer interface [polypeptide binding]; other site 1138871002396 putative active site [active] 1138871002397 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1138871002398 MPT binding site; other site 1138871002399 trimer interface [polypeptide binding]; other site 1138871002400 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1138871002401 MoaE homodimer interface [polypeptide binding]; other site 1138871002402 MoaD interaction [polypeptide binding]; other site 1138871002403 active site residues [active] 1138871002404 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1138871002405 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1138871002406 MoaE interaction surface [polypeptide binding]; other site 1138871002407 MoeB interaction surface [polypeptide binding]; other site 1138871002408 thiocarboxylated glycine; other site 1138871002409 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1138871002410 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1138871002411 FeS/SAM binding site; other site 1138871002412 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1138871002413 hypothetical protein; Provisional; Region: PRK11770 1138871002414 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1138871002415 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1138871002416 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1138871002417 DNA-binding site [nucleotide binding]; DNA binding site 1138871002418 RNA-binding motif; other site 1138871002419 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871002420 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871002421 active site 1138871002422 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1138871002423 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1138871002424 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1138871002425 putative dimer interface [polypeptide binding]; other site 1138871002426 N-terminal domain interface [polypeptide binding]; other site 1138871002427 putative substrate binding pocket (H-site) [chemical binding]; other site 1138871002428 Protein of unknown function (DUF2771); Region: DUF2771; pfam10969 1138871002429 H+ Antiporter protein; Region: 2A0121; TIGR00900 1138871002430 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1138871002431 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1138871002432 hydrophobic ligand binding site; other site 1138871002433 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1138871002434 MarR family; Region: MarR; pfam01047 1138871002435 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1138871002436 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1138871002437 Protein of unknown function (DUF2537); Region: DUF2537; pfam10801 1138871002438 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1138871002439 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1138871002440 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138871002441 catalytic residue [active] 1138871002442 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1138871002443 Ferredoxin [Energy production and conversion]; Region: COG1146 1138871002444 4Fe-4S binding domain; Region: Fer4; pfam00037 1138871002445 ferredoxin-NADP+ reductase; Region: PLN02852 1138871002446 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138871002447 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1138871002448 putative dimer interface [polypeptide binding]; other site 1138871002449 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138871002450 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 1138871002451 dimer interface [polypeptide binding]; other site 1138871002452 Citrate synthase; Region: Citrate_synt; pfam00285 1138871002453 active site 1138871002454 citrylCoA binding site [chemical binding]; other site 1138871002455 oxalacetate/citrate binding site [chemical binding]; other site 1138871002456 coenzyme A binding site [chemical binding]; other site 1138871002457 catalytic triad [active] 1138871002458 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1138871002459 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1138871002460 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1138871002461 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 1138871002462 active site 1138871002463 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1138871002464 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1138871002465 dimer interface [polypeptide binding]; other site 1138871002466 active site 1138871002467 citrylCoA binding site [chemical binding]; other site 1138871002468 NADH binding [chemical binding]; other site 1138871002469 cationic pore residues; other site 1138871002470 oxalacetate/citrate binding site [chemical binding]; other site 1138871002471 coenzyme A binding site [chemical binding]; other site 1138871002472 catalytic triad [active] 1138871002473 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1138871002474 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138871002475 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 1138871002476 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1138871002477 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1138871002478 dimer interface [polypeptide binding]; other site 1138871002479 phosphorylation site [posttranslational modification] 1138871002480 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138871002481 ATP binding site [chemical binding]; other site 1138871002482 Mg2+ binding site [ion binding]; other site 1138871002483 G-X-G motif; other site 1138871002484 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138871002485 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1138871002486 active site 1138871002487 phosphorylation site [posttranslational modification] 1138871002488 intermolecular recognition site; other site 1138871002489 dimerization interface [polypeptide binding]; other site 1138871002490 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1138871002491 DNA binding site [nucleotide binding] 1138871002492 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1138871002493 putative active site [active] 1138871002494 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1138871002495 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 1138871002496 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1138871002497 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138871002498 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138871002499 substrate binding site [chemical binding]; other site 1138871002500 oxyanion hole (OAH) forming residues; other site 1138871002501 trimer interface [polypeptide binding]; other site 1138871002502 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1138871002503 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1138871002504 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1138871002505 Beta-lactamase; Region: Beta-lactamase; pfam00144 1138871002506 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 1138871002507 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1138871002508 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1138871002509 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138871002510 motif II; other site 1138871002511 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 1138871002512 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1138871002513 hydrophobic ligand binding site; other site 1138871002514 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1138871002515 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138871002516 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1138871002517 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138871002518 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138871002519 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1138871002520 active site 1138871002521 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1138871002522 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1138871002523 acetyl-CoA acetyltransferase; Provisional; Region: PRK06289 1138871002524 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138871002525 active site 1138871002526 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 1138871002527 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871002528 PPE family; Region: PPE; pfam00823 1138871002529 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138871002530 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871002531 PPE family; Region: PPE; pfam00823 1138871002532 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 1138871002533 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871002534 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871002535 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1138871002536 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138871002537 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1138871002538 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138871002539 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 1138871002540 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138871002541 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1138871002542 dimerization interface [polypeptide binding]; other site 1138871002543 putative catalytic residue [active] 1138871002544 Protein of unknown function (DUF867); Region: DUF867; pfam05908 1138871002545 manganese transport protein MntH; Reviewed; Region: PRK00701 1138871002546 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1138871002547 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138871002548 short chain dehydrogenase; Provisional; Region: PRK07814 1138871002549 classical (c) SDRs; Region: SDR_c; cd05233 1138871002550 NAD(P) binding site [chemical binding]; other site 1138871002551 active site 1138871002552 PBP superfamily domain; Region: PBP_like_2; cl17296 1138871002553 PBP superfamily domain; Region: PBP_like_2; cl17296 1138871002554 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1138871002555 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138871002556 dimer interface [polypeptide binding]; other site 1138871002557 conserved gate region; other site 1138871002558 putative PBP binding loops; other site 1138871002559 ABC-ATPase subunit interface; other site 1138871002560 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1138871002561 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138871002562 dimer interface [polypeptide binding]; other site 1138871002563 conserved gate region; other site 1138871002564 putative PBP binding loops; other site 1138871002565 ABC-ATPase subunit interface; other site 1138871002566 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1138871002567 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1138871002568 putative DNA binding site [nucleotide binding]; other site 1138871002569 putative homodimer interface [polypeptide binding]; other site 1138871002570 Helix-turn-helix domain; Region: HTH_38; pfam13936 1138871002571 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1138871002572 Integrase core domain; Region: rve; pfam00665 1138871002573 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1138871002574 ATP binding site [chemical binding]; other site 1138871002575 substrate binding site [chemical binding]; other site 1138871002576 Integrase core domain; Region: rve; pfam00665 1138871002577 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1138871002578 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1138871002579 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 1138871002580 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 1138871002581 nucleotide binding site [chemical binding]; other site 1138871002582 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 1138871002583 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1138871002584 active site 1138871002585 DNA binding site [nucleotide binding] 1138871002586 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1138871002587 DNA binding site [nucleotide binding] 1138871002588 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1138871002589 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1138871002590 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1138871002591 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138871002592 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138871002593 enoyl-CoA hydratase; Provisional; Region: PRK08260 1138871002594 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138871002595 substrate binding site [chemical binding]; other site 1138871002596 oxyanion hole (OAH) forming residues; other site 1138871002597 trimer interface [polypeptide binding]; other site 1138871002598 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1138871002599 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138871002600 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1138871002601 anti sigma factor interaction site; other site 1138871002602 regulatory phosphorylation site [posttranslational modification]; other site 1138871002603 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138871002604 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138871002605 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 1138871002606 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 1138871002607 active site 1138871002608 SAM binding site [chemical binding]; other site 1138871002609 homodimer interface [polypeptide binding]; other site 1138871002610 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1138871002611 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 1138871002612 putative DNA binding site [nucleotide binding]; other site 1138871002613 catalytic residue [active] 1138871002614 putative H2TH interface [polypeptide binding]; other site 1138871002615 putative catalytic residues [active] 1138871002616 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1138871002617 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1138871002618 short chain dehydrogenase; Provisional; Region: PRK08251 1138871002619 classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350 1138871002620 putative NAD(P) binding site [chemical binding]; other site 1138871002621 active site 1138871002622 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1138871002623 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1138871002624 active site 1138871002625 dimer interface [polypeptide binding]; other site 1138871002626 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1138871002627 dimer interface [polypeptide binding]; other site 1138871002628 active site 1138871002629 Chorismate mutase type II; Region: CM_2; cl00693 1138871002630 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1138871002631 Part of AAA domain; Region: AAA_19; pfam13245 1138871002632 Family description; Region: UvrD_C_2; pfam13538 1138871002633 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1138871002634 Peptidase family M23; Region: Peptidase_M23; pfam01551 1138871002635 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1138871002636 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1138871002637 CoA-ligase; Region: Ligase_CoA; pfam00549 1138871002638 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1138871002639 CoA binding domain; Region: CoA_binding; smart00881 1138871002640 CoA-ligase; Region: Ligase_CoA; pfam00549 1138871002641 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 1138871002642 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138871002643 Omptin family; Region: Omptin; cl01886 1138871002644 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1138871002645 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138871002646 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1138871002647 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1138871002648 active site 1138871002649 substrate binding site [chemical binding]; other site 1138871002650 cosubstrate binding site; other site 1138871002651 catalytic site [active] 1138871002652 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1138871002653 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1138871002654 purine monophosphate binding site [chemical binding]; other site 1138871002655 dimer interface [polypeptide binding]; other site 1138871002656 putative catalytic residues [active] 1138871002657 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1138871002658 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1138871002659 LGFP repeat; Region: LGFP; pfam08310 1138871002660 LGFP repeat; Region: LGFP; pfam08310 1138871002661 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 1138871002662 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1138871002663 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 1138871002664 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1138871002665 metal ion-dependent adhesion site (MIDAS); other site 1138871002666 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1138871002667 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1138871002668 active site 1138871002669 catalytic tetrad [active] 1138871002670 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1138871002671 enoyl-CoA hydratase; Provisional; Region: PRK07827 1138871002672 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138871002673 substrate binding site [chemical binding]; other site 1138871002674 oxyanion hole (OAH) forming residues; other site 1138871002675 trimer interface [polypeptide binding]; other site 1138871002676 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871002677 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1138871002678 active site 1138871002679 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1138871002680 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1138871002681 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1138871002682 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1138871002683 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1138871002684 carboxyltransferase (CT) interaction site; other site 1138871002685 biotinylation site [posttranslational modification]; other site 1138871002686 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1138871002687 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1138871002688 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1138871002689 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871002690 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871002691 active site 1138871002692 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1138871002693 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1138871002694 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1138871002695 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138871002696 active site 1138871002697 phosphorylation site [posttranslational modification] 1138871002698 intermolecular recognition site; other site 1138871002699 dimerization interface [polypeptide binding]; other site 1138871002700 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1138871002701 DNA binding site [nucleotide binding] 1138871002702 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1138871002703 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1138871002704 dimerization interface [polypeptide binding]; other site 1138871002705 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1138871002706 dimer interface [polypeptide binding]; other site 1138871002707 phosphorylation site [posttranslational modification] 1138871002708 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138871002709 ATP binding site [chemical binding]; other site 1138871002710 Mg2+ binding site [ion binding]; other site 1138871002711 G-X-G motif; other site 1138871002712 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1138871002713 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1138871002714 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1138871002715 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1138871002716 MPT binding site; other site 1138871002717 trimer interface [polypeptide binding]; other site 1138871002718 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1138871002719 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 1138871002720 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1138871002721 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 1138871002722 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 1138871002723 active site 1138871002724 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1138871002725 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1138871002726 dimer interface [polypeptide binding]; other site 1138871002727 putative functional site; other site 1138871002728 putative MPT binding site; other site 1138871002729 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1138871002730 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1138871002731 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1138871002732 MarR family; Region: MarR_2; pfam12802 1138871002733 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1138871002734 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1138871002735 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 1138871002736 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138871002737 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 1138871002738 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1138871002739 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138871002740 DNA-binding site [nucleotide binding]; DNA binding site 1138871002741 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1138871002742 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871002743 Cytochrome P450; Region: p450; pfam00067 1138871002744 Predicted acyl esterases [General function prediction only]; Region: COG2936 1138871002745 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1138871002746 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1138871002747 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1138871002748 metal binding site [ion binding]; metal-binding site 1138871002749 Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605 1138871002750 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1138871002751 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1138871002752 dimer interface [polypeptide binding]; other site 1138871002753 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1138871002754 active site 1138871002755 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 1138871002756 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138871002757 active site 1138871002758 motif I; other site 1138871002759 motif II; other site 1138871002760 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1138871002761 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1138871002762 ligand binding site [chemical binding]; other site 1138871002763 flexible hinge region; other site 1138871002764 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1138871002765 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1138871002766 Coenzyme A binding pocket [chemical binding]; other site 1138871002767 Alkylated DNA repair protein [DNA replication, recombination, and repair]; Region: AlkB; COG3145 1138871002768 Amidinotransferase; Region: Amidinotransf; cl12043 1138871002769 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 1138871002770 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1138871002771 Predicted methyltransferases [General function prediction only]; Region: COG0313 1138871002772 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1138871002773 putative SAM binding site [chemical binding]; other site 1138871002774 putative homodimer interface [polypeptide binding]; other site 1138871002775 aminodeoxychorismate synthase component I; Provisional; Region: PRK05877 1138871002776 chorismate binding enzyme; Region: Chorismate_bind; cl10555 1138871002777 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1138871002778 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138871002779 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1138871002780 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1138871002781 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138871002782 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1138871002783 GAF domain; Region: GAF; pfam01590 1138871002784 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1138871002785 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1138871002786 metal binding site [ion binding]; metal-binding site 1138871002787 active site 1138871002788 I-site; other site 1138871002789 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1138871002790 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1138871002791 Chain length determinant protein; Region: Wzz; pfam02706 1138871002792 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 1138871002793 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1138871002794 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1138871002795 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1138871002796 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1138871002797 active site 1138871002798 catalytic tetrad [active] 1138871002799 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1138871002800 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1138871002801 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1138871002802 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1138871002803 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1138871002804 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 1138871002805 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 1138871002806 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1138871002807 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1138871002808 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1138871002809 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1138871002810 active site 1138871002811 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1138871002812 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1138871002813 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1138871002814 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1138871002815 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1138871002816 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1138871002817 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1138871002818 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1138871002819 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871002820 PPE family; Region: PPE; pfam00823 1138871002821 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138871002822 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871002823 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871002824 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1138871002825 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1138871002826 active site 1138871002827 non-prolyl cis peptide bond; other site 1138871002828 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1138871002829 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 1138871002830 Dibenzothiophene (DBT) desulfurization enzyme C; Region: DszC; cd01163 1138871002831 Flavin binding site [chemical binding]; other site 1138871002832 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1138871002833 MULE transposase domain; Region: MULE; pfam10551 1138871002834 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871002835 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871002836 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1138871002837 PAS domain; Region: PAS_9; pfam13426 1138871002838 putative active site [active] 1138871002839 heme pocket [chemical binding]; other site 1138871002840 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871002841 WHG domain; Region: WHG; pfam13305 1138871002842 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 1138871002843 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1138871002844 active site 1138871002845 HIGH motif; other site 1138871002846 KMSKS motif; other site 1138871002847 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1138871002848 tRNA binding surface [nucleotide binding]; other site 1138871002849 anticodon binding site; other site 1138871002850 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1138871002851 active site 1138871002852 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1138871002853 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1138871002854 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1138871002855 G5 domain; Region: G5; pfam07501 1138871002856 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1138871002857 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1138871002858 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871002859 S-adenosylmethionine binding site [chemical binding]; other site 1138871002860 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1138871002861 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 1138871002862 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871002863 acyl-activating enzyme (AAE) consensus motif; other site 1138871002864 AMP binding site [chemical binding]; other site 1138871002865 active site 1138871002866 CoA binding site [chemical binding]; other site 1138871002867 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1138871002868 putative active site [active] 1138871002869 catalytic residue [active] 1138871002870 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1138871002871 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 1138871002872 5S rRNA interface [nucleotide binding]; other site 1138871002873 CTC domain interface [polypeptide binding]; other site 1138871002874 L16 interface [polypeptide binding]; other site 1138871002875 short chain dehydrogenase; Provisional; Region: PRK06197 1138871002876 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1138871002877 putative NAD(P) binding site [chemical binding]; other site 1138871002878 active site 1138871002879 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871002880 Cytochrome P450; Region: p450; cl12078 1138871002881 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1138871002882 cyclase homology domain; Region: CHD; cd07302 1138871002883 nucleotidyl binding site; other site 1138871002884 metal binding site [ion binding]; metal-binding site 1138871002885 dimer interface [polypeptide binding]; other site 1138871002886 Predicted ATPase [General function prediction only]; Region: COG3903 1138871002887 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1138871002888 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1138871002889 DNA binding residues [nucleotide binding] 1138871002890 dimerization interface [polypeptide binding]; other site 1138871002891 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1138871002892 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1138871002893 ArsC family; Region: ArsC; pfam03960 1138871002894 catalytic residues [active] 1138871002895 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1138871002896 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1138871002897 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1138871002898 active site 1138871002899 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 1138871002900 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1138871002901 Substrate binding site; other site 1138871002902 Mg++ binding site; other site 1138871002903 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1138871002904 active site 1138871002905 substrate binding site [chemical binding]; other site 1138871002906 CoA binding site [chemical binding]; other site 1138871002907 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871002908 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871002909 Helix-turn-helix domain; Region: HTH_38; pfam13936 1138871002910 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1138871002911 Integrase core domain; Region: rve; pfam00665 1138871002912 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1138871002913 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1138871002914 active site 1138871002915 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1138871002916 substrate binding site [chemical binding]; other site 1138871002917 catalytic residues [active] 1138871002918 dimer interface [polypeptide binding]; other site 1138871002919 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1138871002920 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1138871002921 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1138871002922 ATP binding site [chemical binding]; other site 1138871002923 putative Mg++ binding site [ion binding]; other site 1138871002924 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1138871002925 nucleotide binding region [chemical binding]; other site 1138871002926 ATP-binding site [chemical binding]; other site 1138871002927 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1138871002928 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 1138871002929 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1138871002930 homodimer interface [polypeptide binding]; other site 1138871002931 metal binding site [ion binding]; metal-binding site 1138871002932 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1138871002933 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1138871002934 enolase; Provisional; Region: eno; PRK00077 1138871002935 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1138871002936 dimer interface [polypeptide binding]; other site 1138871002937 metal binding site [ion binding]; metal-binding site 1138871002938 substrate binding pocket [chemical binding]; other site 1138871002939 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1138871002940 Septum formation initiator; Region: DivIC; pfam04977 1138871002941 Uncharacterized conserved protein [Function unknown]; Region: COG1507 1138871002942 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1138871002943 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1138871002944 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1138871002945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138871002946 active site 1138871002947 phosphorylation site [posttranslational modification] 1138871002948 intermolecular recognition site; other site 1138871002949 dimerization interface [polypeptide binding]; other site 1138871002950 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1138871002951 DNA binding site [nucleotide binding] 1138871002952 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1138871002953 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1138871002954 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1138871002955 Ligand Binding Site [chemical binding]; other site 1138871002956 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1138871002957 dimer interface [polypeptide binding]; other site 1138871002958 phosphorylation site [posttranslational modification] 1138871002959 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138871002960 ATP binding site [chemical binding]; other site 1138871002961 Mg2+ binding site [ion binding]; other site 1138871002962 G-X-G motif; other site 1138871002963 K+-transporting ATPase, c chain; Region: KdpC; cl00944 1138871002964 K+-transporting ATPase, c chain; Region: KdpC; cl00944 1138871002965 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1138871002966 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1138871002967 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1138871002968 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1138871002969 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1138871002970 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1138871002971 dimer interface [polypeptide binding]; other site 1138871002972 phosphorylation site [posttranslational modification] 1138871002973 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138871002974 ATP binding site [chemical binding]; other site 1138871002975 Mg2+ binding site [ion binding]; other site 1138871002976 G-X-G motif; other site 1138871002977 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1138871002978 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138871002979 active site 1138871002980 phosphorylation site [posttranslational modification] 1138871002981 intermolecular recognition site; other site 1138871002982 dimerization interface [polypeptide binding]; other site 1138871002983 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1138871002984 DNA binding site [nucleotide binding] 1138871002985 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1138871002986 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1138871002987 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871002988 PPE family; Region: PPE; pfam00823 1138871002989 PE family; Region: PE; pfam00934 1138871002990 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138871002991 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1138871002992 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871002993 S-adenosylmethionine binding site [chemical binding]; other site 1138871002994 Domain of unknown function (DUF427); Region: DUF427; cl00998 1138871002995 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1138871002996 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1138871002997 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1138871002998 Helix-turn-helix domain; Region: HTH_38; pfam13936 1138871002999 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1138871003000 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1138871003001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138871003002 Walker A motif; other site 1138871003003 ATP binding site [chemical binding]; other site 1138871003004 Walker B motif; other site 1138871003005 Homeodomain-like domain; Region: HTH_23; pfam13384 1138871003006 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1138871003007 Integrase core domain; Region: rve; pfam00665 1138871003008 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1138871003009 Integrase core domain; Region: rve; pfam00665 1138871003010 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1138871003011 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 1138871003012 dimer interface [polypeptide binding]; other site 1138871003013 acyl-activating enzyme (AAE) consensus motif; other site 1138871003014 putative active site [active] 1138871003015 AMP binding site [chemical binding]; other site 1138871003016 putative CoA binding site [chemical binding]; other site 1138871003017 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1138871003018 hydrophobic ligand binding site; other site 1138871003019 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1138871003020 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1138871003021 putative active site [active] 1138871003022 putative dimer interface [polypeptide binding]; other site 1138871003023 Patatin-like phospholipase; Region: Patatin; pfam01734 1138871003024 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1138871003025 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1138871003026 active site 1138871003027 nucleophile elbow; other site 1138871003028 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 1138871003029 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1138871003030 active site residue [active] 1138871003031 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871003032 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871003033 Predicted membrane protein [Function unknown]; Region: COG4425 1138871003034 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 1138871003035 enoyl-CoA hydratase; Provisional; Region: PRK05862 1138871003036 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138871003037 substrate binding site [chemical binding]; other site 1138871003038 oxyanion hole (OAH) forming residues; other site 1138871003039 trimer interface [polypeptide binding]; other site 1138871003040 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1138871003041 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138871003042 substrate binding site [chemical binding]; other site 1138871003043 oxyanion hole (OAH) forming residues; other site 1138871003044 trimer interface [polypeptide binding]; other site 1138871003045 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1138871003046 Bax inhibitor 1 like; Region: BaxI_1; cl17691 1138871003047 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 1138871003048 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138871003049 dimer interface [polypeptide binding]; other site 1138871003050 active site 1138871003051 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 1138871003052 active site 1138871003053 catalytic triad [active] 1138871003054 oxyanion hole [active] 1138871003055 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1138871003056 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138871003057 substrate binding pocket [chemical binding]; other site 1138871003058 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 1138871003059 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1138871003060 dimer interface [polypeptide binding]; other site 1138871003061 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138871003062 catalytic residue [active] 1138871003063 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 1138871003064 RDD family; Region: RDD; pfam06271 1138871003065 cystathionine gamma-synthase; Provisional; Region: PRK07811 1138871003066 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1138871003067 homodimer interface [polypeptide binding]; other site 1138871003068 substrate-cofactor binding pocket; other site 1138871003069 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138871003070 catalytic residue [active] 1138871003071 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1138871003072 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1138871003073 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1138871003074 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 1138871003075 mycothiol conjugate amidase Mca; Region: mycothiol_Mca; TIGR03446 1138871003076 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1138871003077 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1138871003078 catalytic residues [active] 1138871003079 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1138871003080 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1138871003081 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1138871003082 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1138871003083 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1138871003084 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1138871003085 catalytic residue [active] 1138871003086 putative FPP diphosphate binding site; other site 1138871003087 putative FPP binding hydrophobic cleft; other site 1138871003088 dimer interface [polypeptide binding]; other site 1138871003089 putative IPP diphosphate binding site; other site 1138871003090 pantothenate kinase; Provisional; Region: PRK05439 1138871003091 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1138871003092 ATP-binding site [chemical binding]; other site 1138871003093 CoA-binding site [chemical binding]; other site 1138871003094 Mg2+-binding site [ion binding]; other site 1138871003095 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1138871003096 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1138871003097 dimer interface [polypeptide binding]; other site 1138871003098 active site 1138871003099 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1138871003100 folate binding site [chemical binding]; other site 1138871003101 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1138871003102 dinuclear metal binding motif [ion binding]; other site 1138871003103 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1138871003104 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1138871003105 putative active site [active] 1138871003106 PhoH-like protein; Region: PhoH; pfam02562 1138871003107 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1138871003108 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1138871003109 NodB motif; other site 1138871003110 active site 1138871003111 catalytic site [active] 1138871003112 metal binding site [ion binding]; metal-binding site 1138871003113 HAMP domain; Region: HAMP; pfam00672 1138871003114 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1138871003115 cyclase homology domain; Region: CHD; cd07302 1138871003116 nucleotidyl binding site; other site 1138871003117 metal binding site [ion binding]; metal-binding site 1138871003118 dimer interface [polypeptide binding]; other site 1138871003119 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1138871003120 Class II fumarases; Region: Fumarase_classII; cd01362 1138871003121 active site 1138871003122 tetramer interface [polypeptide binding]; other site 1138871003123 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1138871003124 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1138871003125 putative active site [active] 1138871003126 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 1138871003127 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1138871003128 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1138871003129 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1138871003130 homodimer interface [polypeptide binding]; other site 1138871003131 active site 1138871003132 TDP-binding site; other site 1138871003133 acceptor substrate-binding pocket; other site 1138871003134 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138871003135 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1138871003136 acyl-activating enzyme (AAE) consensus motif; other site 1138871003137 AMP binding site [chemical binding]; other site 1138871003138 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138871003139 Condensation domain; Region: Condensation; pfam00668 1138871003140 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1138871003141 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1138871003142 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1138871003143 substrate binding pocket [chemical binding]; other site 1138871003144 catalytic triad [active] 1138871003145 3beta-hydroxysteroid dehydrogenases (3b-HSD)-like, extended (e) SDRs; Region: 3b-HSD-like_SDR_e; cd05241 1138871003146 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 1138871003147 putative NAD(P) binding site [chemical binding]; other site 1138871003148 active site 1138871003149 putative substrate binding site [chemical binding]; other site 1138871003150 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1138871003151 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 1138871003152 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1138871003153 generic binding surface II; other site 1138871003154 generic binding surface I; other site 1138871003155 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1138871003156 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1138871003157 Membrane protein of unknown function; Region: DUF360; cl00850 1138871003158 GTP-binding protein YchF; Reviewed; Region: PRK09601 1138871003159 YchF GTPase; Region: YchF; cd01900 1138871003160 G1 box; other site 1138871003161 GTP/Mg2+ binding site [chemical binding]; other site 1138871003162 Switch I region; other site 1138871003163 G2 box; other site 1138871003164 Switch II region; other site 1138871003165 G3 box; other site 1138871003166 G4 box; other site 1138871003167 G5 box; other site 1138871003168 Protein of unknown function (DUF933); Region: YchF-GTPase_C; pfam06071 1138871003169 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1138871003170 Phosphotransferase enzyme family; Region: APH; pfam01636 1138871003171 active site 1138871003172 ATP binding site [chemical binding]; other site 1138871003173 substrate binding site [chemical binding]; other site 1138871003174 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 1138871003175 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 1138871003176 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 1138871003177 putative dimer interface [polypeptide binding]; other site 1138871003178 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138871003179 ligand binding site [chemical binding]; other site 1138871003180 Zn binding site [ion binding]; other site 1138871003181 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1138871003182 active site 1138871003183 metal binding site [ion binding]; metal-binding site 1138871003184 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 1138871003185 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: VapC; COG1487 1138871003186 putative active site [active] 1138871003187 NlpC/P60 family; Region: NLPC_P60; cl17555 1138871003188 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1138871003189 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138871003190 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1138871003191 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1138871003192 cyclase homology domain; Region: CHD; cd07302 1138871003193 nucleotidyl binding site; other site 1138871003194 metal binding site [ion binding]; metal-binding site 1138871003195 dimer interface [polypeptide binding]; other site 1138871003196 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12853 1138871003197 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1138871003198 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1138871003199 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 1138871003200 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1138871003201 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138871003202 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138871003203 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1138871003204 dimer interface [polypeptide binding]; other site 1138871003205 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138871003206 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138871003207 pyruvate phosphate dikinase; Provisional; Region: PRK05878 1138871003208 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1138871003209 Predicted membrane protein [Function unknown]; Region: COG2259 1138871003210 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1138871003211 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138871003212 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1138871003213 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1138871003214 TrkA-C domain; Region: TrkA_C; pfam02080 1138871003215 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1138871003216 TrkA-N domain; Region: TrkA_N; pfam02254 1138871003217 TrkA-C domain; Region: TrkA_C; pfam02080 1138871003218 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 1138871003219 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1138871003220 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1138871003221 THF binding site; other site 1138871003222 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1138871003223 substrate binding site [chemical binding]; other site 1138871003224 THF binding site; other site 1138871003225 zinc-binding site [ion binding]; other site 1138871003226 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871003227 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1138871003228 NAD(P) binding site [chemical binding]; other site 1138871003229 active site 1138871003230 short chain dehydrogenase; Provisional; Region: PRK12829 1138871003231 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871003232 NAD(P) binding site [chemical binding]; other site 1138871003233 active site 1138871003234 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871003235 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871003236 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871003237 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871003238 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1138871003239 FMN binding site [chemical binding]; other site 1138871003240 dimer interface [polypeptide binding]; other site 1138871003241 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1138871003242 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138871003243 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871003244 active site 1138871003245 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871003246 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1138871003247 active site 1138871003248 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1138871003249 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871003250 short chain dehydrogenase; Provisional; Region: PRK07791 1138871003251 NAD(P) binding site [chemical binding]; other site 1138871003252 active site 1138871003253 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1138871003254 metal ion-dependent adhesion site (MIDAS); other site 1138871003255 MoxR-like ATPases [General function prediction only]; Region: COG0714 1138871003256 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 1138871003257 Walker A motif; other site 1138871003258 ATP binding site [chemical binding]; other site 1138871003259 Walker B motif; other site 1138871003260 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 1138871003261 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1138871003262 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1138871003263 ligand binding site [chemical binding]; other site 1138871003264 short chain dehydrogenase; Provisional; Region: PRK06179 1138871003265 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1138871003266 NADP binding site [chemical binding]; other site 1138871003267 active site 1138871003268 steroid binding site; other site 1138871003269 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871003270 Cytochrome P450; Region: p450; cl12078 1138871003271 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 1138871003272 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1138871003273 NAD binding site [chemical binding]; other site 1138871003274 catalytic residues [active] 1138871003275 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1138871003276 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138871003277 dimer interface [polypeptide binding]; other site 1138871003278 active site 1138871003279 enoyl-CoA hydratase; Provisional; Region: PRK08252 1138871003280 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138871003281 substrate binding site [chemical binding]; other site 1138871003282 oxyanion hole (OAH) forming residues; other site 1138871003283 trimer interface [polypeptide binding]; other site 1138871003284 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1138871003285 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1138871003286 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 1138871003287 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1138871003288 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1138871003289 malonyl-CoA binding site [chemical binding]; other site 1138871003290 dimer interface [polypeptide binding]; other site 1138871003291 active site 1138871003292 product binding site; other site 1138871003293 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1138871003294 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871003295 NAD(P) binding site [chemical binding]; other site 1138871003296 active site 1138871003297 CAAX protease self-immunity; Region: Abi; pfam02517 1138871003298 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 1138871003299 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1138871003300 putative NAD(P) binding site [chemical binding]; other site 1138871003301 putative active site [active] 1138871003302 enoyl-CoA hydratase; Provisional; Region: PRK06688 1138871003303 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138871003304 substrate binding site [chemical binding]; other site 1138871003305 oxyanion hole (OAH) forming residues; other site 1138871003306 trimer interface [polypeptide binding]; other site 1138871003307 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138871003308 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138871003309 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 1138871003310 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 1138871003311 NAD binding site [chemical binding]; other site 1138871003312 homodimer interface [polypeptide binding]; other site 1138871003313 homotetramer interface [polypeptide binding]; other site 1138871003314 active site 1138871003315 MMPL family; Region: MMPL; pfam03176 1138871003316 MMPL family; Region: MMPL; pfam03176 1138871003317 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1138871003318 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871003319 S-adenosylmethionine binding site [chemical binding]; other site 1138871003320 NAD-dependent deacetylase; Provisional; Region: PRK00481 1138871003321 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1138871003322 NAD+ binding site [chemical binding]; other site 1138871003323 substrate binding site [chemical binding]; other site 1138871003324 Zn binding site [ion binding]; other site 1138871003325 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138871003326 DNA-binding site [nucleotide binding]; DNA binding site 1138871003327 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 1138871003328 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1138871003329 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1138871003330 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1138871003331 minor groove reading motif; other site 1138871003332 mannosyltransferase; Provisional; Region: pimE; PRK13375 1138871003333 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1138871003334 aromatic arch; other site 1138871003335 DCoH dimer interaction site [polypeptide binding]; other site 1138871003336 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1138871003337 DCoH tetramer interaction site [polypeptide binding]; other site 1138871003338 substrate binding site [chemical binding]; other site 1138871003339 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1138871003340 active site 1138871003341 8-oxo-dGMP binding site [chemical binding]; other site 1138871003342 nudix motif; other site 1138871003343 metal binding site [ion binding]; metal-binding site 1138871003344 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1138871003345 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1138871003346 [4Fe-4S] binding site [ion binding]; other site 1138871003347 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1138871003348 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1138871003349 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1138871003350 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1138871003351 molybdopterin cofactor binding site; other site 1138871003352 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1138871003353 Nitrate reductase delta subunit [Energy production and conversion]; Region: NarJ; COG2180 1138871003354 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1138871003355 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1138871003356 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1138871003357 G1 box; other site 1138871003358 putative GEF interaction site [polypeptide binding]; other site 1138871003359 GTP/Mg2+ binding site [chemical binding]; other site 1138871003360 Switch I region; other site 1138871003361 G2 box; other site 1138871003362 G3 box; other site 1138871003363 Switch II region; other site 1138871003364 G4 box; other site 1138871003365 G5 box; other site 1138871003366 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1138871003367 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1138871003368 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1138871003369 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1138871003370 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1138871003371 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871003372 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871003373 N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D- glucopyranoside deacetylase; Region: mycothiol_MshB; TIGR03445 1138871003374 FO synthase; Reviewed; Region: fbiC; PRK09234 1138871003375 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1138871003376 FeS/SAM binding site; other site 1138871003377 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1138871003378 FeS/SAM binding site; other site 1138871003379 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 1138871003380 4Fe-4S binding domain; Region: Fer4; pfam00037 1138871003381 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 1138871003382 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1138871003383 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138871003384 homodimer interface [polypeptide binding]; other site 1138871003385 catalytic residue [active] 1138871003386 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1138871003387 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1138871003388 generic binding surface II; other site 1138871003389 ssDNA binding site; other site 1138871003390 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1138871003391 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138871003392 active site 1138871003393 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1138871003394 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1138871003395 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871003396 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1138871003397 Enoylreductase; Region: PKS_ER; smart00829 1138871003398 NAD(P) binding site [chemical binding]; other site 1138871003399 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1138871003400 KR domain; Region: KR; pfam08659 1138871003401 putative NADP binding site [chemical binding]; other site 1138871003402 active site 1138871003403 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138871003404 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871003405 PPE family; Region: PPE; pfam00823 1138871003406 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138871003407 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871003408 PPE family; Region: PPE; pfam00823 1138871003409 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138871003410 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1138871003411 ligand-binding site [chemical binding]; other site 1138871003412 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1138871003413 ATP-sulfurylase; Region: ATPS; cd00517 1138871003414 active site 1138871003415 HXXH motif; other site 1138871003416 flexible loop; other site 1138871003417 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1138871003418 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1138871003419 acyl-CoA synthetase; Validated; Region: PRK05850 1138871003420 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1138871003421 acyl-activating enzyme (AAE) consensus motif; other site 1138871003422 active site 1138871003423 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871003424 PPE family; Region: PPE; pfam00823 1138871003425 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1138871003426 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1138871003427 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1138871003428 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 1138871003429 NAD(P) binding site [chemical binding]; other site 1138871003430 catalytic residues [active] 1138871003431 Proline dehydrogenase; Region: Pro_dh; cl03282 1138871003432 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 1138871003433 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871003434 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871003435 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1138871003436 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1138871003437 NAD(P) binding site [chemical binding]; other site 1138871003438 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871003439 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871003440 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138871003441 lipid-transfer protein; Provisional; Region: PRK07855 1138871003442 active site 1138871003443 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 1138871003444 putative active site [active] 1138871003445 putative catalytic site [active] 1138871003446 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1138871003447 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138871003448 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1138871003449 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138871003450 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1138871003451 NAD binding site [chemical binding]; other site 1138871003452 catalytic residues [active] 1138871003453 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138871003454 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 1138871003455 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138871003456 acyl-CoA synthetase; Validated; Region: PRK07787 1138871003457 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871003458 acyl-activating enzyme (AAE) consensus motif; other site 1138871003459 AMP binding site [chemical binding]; other site 1138871003460 active site 1138871003461 CoA binding site [chemical binding]; other site 1138871003462 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138871003463 metabolite-proton symporter; Region: 2A0106; TIGR00883 1138871003464 putative substrate translocation pore; other site 1138871003465 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1138871003466 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1138871003467 putative trimer interface [polypeptide binding]; other site 1138871003468 putative CoA binding site [chemical binding]; other site 1138871003469 PE family; Region: PE; pfam00934 1138871003470 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138871003471 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871003472 PPE family; Region: PPE; pfam00823 1138871003473 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 1138871003474 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1138871003475 metal binding site [ion binding]; metal-binding site 1138871003476 putative dimer interface [polypeptide binding]; other site 1138871003477 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1138871003478 long-chain-acyl-CoA synthetase; Validated; Region: PRK08279 1138871003479 Fatty acid transport proteins (FATP) play dual roles as fatty acid transporters and its activation enzymes; Region: FATP_FACS; cd05940 1138871003480 acyl-activating enzyme (AAE) consensus motif; other site 1138871003481 putative AMP binding site [chemical binding]; other site 1138871003482 putative active site [active] 1138871003483 putative CoA binding site [chemical binding]; other site 1138871003484 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1138871003485 dihydropteroate synthase; Region: DHPS; TIGR01496 1138871003486 substrate binding pocket [chemical binding]; other site 1138871003487 dimer interface [polypeptide binding]; other site 1138871003488 inhibitor binding site; inhibition site 1138871003489 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 1138871003490 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1138871003491 DivIVA domain; Region: DivI1A_domain; TIGR03544 1138871003492 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 1138871003493 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 1138871003494 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1138871003495 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1138871003496 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1138871003497 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1138871003498 ligand binding site; other site 1138871003499 oligomer interface; other site 1138871003500 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1138871003501 dimer interface [polypeptide binding]; other site 1138871003502 N-terminal domain interface [polypeptide binding]; other site 1138871003503 sulfate 1 binding site; other site 1138871003504 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1138871003505 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 1138871003506 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1138871003507 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1138871003508 Walker A/P-loop; other site 1138871003509 ATP binding site [chemical binding]; other site 1138871003510 Q-loop/lid; other site 1138871003511 ABC transporter signature motif; other site 1138871003512 Walker B; other site 1138871003513 D-loop; other site 1138871003514 H-loop/switch region; other site 1138871003515 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1138871003516 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871003517 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871003518 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1138871003519 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871003520 S-adenosylmethionine binding site [chemical binding]; other site 1138871003521 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 1138871003522 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138871003523 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138871003524 DNA binding residues [nucleotide binding] 1138871003525 Putative zinc-finger; Region: zf-HC2; pfam13490 1138871003526 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1138871003527 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1138871003528 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1138871003529 protein binding site [polypeptide binding]; other site 1138871003530 sec-independent translocase; Provisional; Region: PRK03100 1138871003531 Domain of unknown function DUF59; Region: DUF59; cl00941 1138871003532 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1138871003533 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1138871003534 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 1138871003535 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1138871003536 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1138871003537 catalytic residue [active] 1138871003538 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 1138871003539 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1138871003540 MgtE intracellular N domain; Region: MgtE_N; smart00924 1138871003541 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1138871003542 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1138871003543 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1138871003544 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1138871003545 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138871003546 dimer interface [polypeptide binding]; other site 1138871003547 conserved gate region; other site 1138871003548 putative PBP binding loops; other site 1138871003549 ABC-ATPase subunit interface; other site 1138871003550 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1138871003551 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138871003552 dimer interface [polypeptide binding]; other site 1138871003553 conserved gate region; other site 1138871003554 ABC-ATPase subunit interface; other site 1138871003555 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1138871003556 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1138871003557 Walker A/P-loop; other site 1138871003558 ATP binding site [chemical binding]; other site 1138871003559 Q-loop/lid; other site 1138871003560 ABC transporter signature motif; other site 1138871003561 Walker B; other site 1138871003562 D-loop; other site 1138871003563 H-loop/switch region; other site 1138871003564 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1138871003565 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1138871003566 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1138871003567 putative active site [active] 1138871003568 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1138871003569 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 1138871003570 oligomer interface [polypeptide binding]; other site 1138871003571 metal binding site [ion binding]; metal-binding site 1138871003572 metal binding site [ion binding]; metal-binding site 1138871003573 putative Cl binding site [ion binding]; other site 1138871003574 basic sphincter; other site 1138871003575 hydrophobic gate; other site 1138871003576 periplasmic entrance; other site 1138871003577 malate dehydrogenase; Provisional; Region: PRK05442 1138871003578 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 1138871003579 NAD(P) binding site [chemical binding]; other site 1138871003580 dimer interface [polypeptide binding]; other site 1138871003581 malate binding site [chemical binding]; other site 1138871003582 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1138871003583 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1138871003584 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1138871003585 putative NAD(P) binding site [chemical binding]; other site 1138871003586 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1138871003587 short chain dehydrogenase; Provisional; Region: PRK07832 1138871003588 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871003589 NAD(P) binding site [chemical binding]; other site 1138871003590 active site 1138871003591 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1138871003592 classical (c) SDRs; Region: SDR_c; cd05233 1138871003593 NAD(P) binding site [chemical binding]; other site 1138871003594 active site 1138871003595 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1138871003596 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1138871003597 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1138871003598 TPP-binding site [chemical binding]; other site 1138871003599 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1138871003600 dimer interface [polypeptide binding]; other site 1138871003601 PYR/PP interface [polypeptide binding]; other site 1138871003602 TPP binding site [chemical binding]; other site 1138871003603 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138871003604 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1138871003605 putative substrate translocation pore; other site 1138871003606 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 1138871003607 RNase_H superfamily; Region: RNase_H_2; pfam13482 1138871003608 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1138871003609 Part of AAA domain; Region: AAA_19; pfam13245 1138871003610 AAA domain; Region: AAA_12; pfam13087 1138871003611 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1138871003612 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1138871003613 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1138871003614 ATP binding site [chemical binding]; other site 1138871003615 Mg++ binding site [ion binding]; other site 1138871003616 motif III; other site 1138871003617 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1138871003618 nucleotide binding region [chemical binding]; other site 1138871003619 ATP-binding site [chemical binding]; other site 1138871003620 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1138871003621 putative RNA binding site [nucleotide binding]; other site 1138871003622 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1138871003623 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871003624 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871003625 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871003626 FAD binding domain; Region: FAD_binding_4; pfam01565 1138871003627 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1138871003628 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 1138871003629 Fe-S cluster binding site [ion binding]; other site 1138871003630 DNA binding site [nucleotide binding] 1138871003631 active site 1138871003632 hypothetical protein; Validated; Region: PRK05868 1138871003633 hypothetical protein; Provisional; Region: PRK07236 1138871003634 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1138871003635 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138871003636 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1138871003637 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1138871003638 metal binding site [ion binding]; metal-binding site 1138871003639 active site 1138871003640 I-site; other site 1138871003641 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1138871003642 metal binding site [ion binding]; metal-binding site 1138871003643 active site 1138871003644 I-site; other site 1138871003645 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1138871003646 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1138871003647 HIT family signature motif; other site 1138871003648 catalytic residue [active] 1138871003649 amidase; Provisional; Region: PRK12470 1138871003650 Amidase; Region: Amidase; pfam01425 1138871003651 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 1138871003652 putative active site [active] 1138871003653 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1138871003654 cyclase homology domain; Region: CHD; cd07302 1138871003655 nucleotidyl binding site; other site 1138871003656 metal binding site [ion binding]; metal-binding site 1138871003657 dimer interface [polypeptide binding]; other site 1138871003658 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1138871003659 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1138871003660 active site 1138871003661 ATP binding site [chemical binding]; other site 1138871003662 substrate binding site [chemical binding]; other site 1138871003663 activation loop (A-loop); other site 1138871003664 PknH-like extracellular domain; Region: PknH_C; pfam14032 1138871003665 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1138871003666 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1138871003667 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1138871003668 Walker A/P-loop; other site 1138871003669 ATP binding site [chemical binding]; other site 1138871003670 Q-loop/lid; other site 1138871003671 ABC transporter signature motif; other site 1138871003672 Walker B; other site 1138871003673 D-loop; other site 1138871003674 H-loop/switch region; other site 1138871003675 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1138871003676 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1138871003677 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138871003678 Walker A/P-loop; other site 1138871003679 ATP binding site [chemical binding]; other site 1138871003680 Q-loop/lid; other site 1138871003681 ABC transporter signature motif; other site 1138871003682 Walker B; other site 1138871003683 D-loop; other site 1138871003684 H-loop/switch region; other site 1138871003685 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1138871003686 Protein of unknown function (DUF3558); Region: DUF3558; pfam12079 1138871003687 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1138871003688 catalytic core [active] 1138871003689 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1138871003690 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1138871003691 active site 1138871003692 metal binding site [ion binding]; metal-binding site 1138871003693 DNA binding site [nucleotide binding] 1138871003694 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138871003695 Walker A/P-loop; other site 1138871003696 ATP binding site [chemical binding]; other site 1138871003697 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138871003698 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1138871003699 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 1138871003700 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1138871003701 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1138871003702 Walker A/P-loop; other site 1138871003703 ATP binding site [chemical binding]; other site 1138871003704 Q-loop/lid; other site 1138871003705 ABC transporter signature motif; other site 1138871003706 Walker B; other site 1138871003707 D-loop; other site 1138871003708 H-loop/switch region; other site 1138871003709 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1138871003710 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1138871003711 Walker A/P-loop; other site 1138871003712 ATP binding site [chemical binding]; other site 1138871003713 Q-loop/lid; other site 1138871003714 ABC transporter signature motif; other site 1138871003715 Walker B; other site 1138871003716 D-loop; other site 1138871003717 H-loop/switch region; other site 1138871003718 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1138871003719 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1138871003720 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1138871003721 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138871003722 dimer interface [polypeptide binding]; other site 1138871003723 conserved gate region; other site 1138871003724 putative PBP binding loops; other site 1138871003725 ABC-ATPase subunit interface; other site 1138871003726 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1138871003727 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138871003728 dimer interface [polypeptide binding]; other site 1138871003729 conserved gate region; other site 1138871003730 putative PBP binding loops; other site 1138871003731 ABC-ATPase subunit interface; other site 1138871003732 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1138871003733 active site clefts [active] 1138871003734 zinc binding site [ion binding]; other site 1138871003735 dimer interface [polypeptide binding]; other site 1138871003736 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1138871003737 CoenzymeA binding site [chemical binding]; other site 1138871003738 subunit interaction site [polypeptide binding]; other site 1138871003739 PHB binding site; other site 1138871003740 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1138871003741 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1138871003742 Active Sites [active] 1138871003743 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 1138871003744 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1138871003745 CysD dimerization site [polypeptide binding]; other site 1138871003746 G1 box; other site 1138871003747 putative GEF interaction site [polypeptide binding]; other site 1138871003748 GTP/Mg2+ binding site [chemical binding]; other site 1138871003749 Switch I region; other site 1138871003750 G2 box; other site 1138871003751 G3 box; other site 1138871003752 Switch II region; other site 1138871003753 G4 box; other site 1138871003754 G5 box; other site 1138871003755 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1138871003756 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1138871003757 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1138871003758 ligand-binding site [chemical binding]; other site 1138871003759 Rrf2 family protein; Region: rrf2_super; TIGR00738 1138871003760 Transcriptional regulator; Region: Rrf2; pfam02082 1138871003761 ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351 1138871003762 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138871003763 metal binding site [ion binding]; metal-binding site 1138871003764 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 1138871003765 putative dimer interface [polypeptide binding]; other site 1138871003766 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138871003767 ligand binding site [chemical binding]; other site 1138871003768 Zn binding site [ion binding]; other site 1138871003769 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1138871003770 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1138871003771 Ion channel; Region: Ion_trans_2; pfam07885 1138871003772 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1138871003773 TrkA-N domain; Region: TrkA_N; pfam02254 1138871003774 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1138871003775 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 1138871003776 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1138871003777 dimer interface [polypeptide binding]; other site 1138871003778 ADP-ribose binding site [chemical binding]; other site 1138871003779 active site 1138871003780 nudix motif; other site 1138871003781 metal binding site [ion binding]; metal-binding site 1138871003782 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1138871003783 active site 1138871003784 catalytic residues [active] 1138871003785 DNA binding site [nucleotide binding] 1138871003786 Int/Topo IB signature motif; other site 1138871003787 Helix-turn-helix domain; Region: HTH_17; pfam12728 1138871003788 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1138871003789 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1138871003790 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1138871003791 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1138871003792 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1138871003793 active site 1138871003794 HIGH motif; other site 1138871003795 KMSK motif region; other site 1138871003796 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1138871003797 tRNA binding surface [nucleotide binding]; other site 1138871003798 anticodon binding site; other site 1138871003799 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1138871003800 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1138871003801 active site 1138871003802 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1138871003803 substrate binding site [chemical binding]; other site 1138871003804 catalytic residues [active] 1138871003805 dimer interface [polypeptide binding]; other site 1138871003806 homoserine dehydrogenase; Provisional; Region: PRK06349 1138871003807 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1138871003808 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1138871003809 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1138871003810 threonine synthase; Reviewed; Region: PRK06721 1138871003811 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1138871003812 homodimer interface [polypeptide binding]; other site 1138871003813 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138871003814 catalytic residue [active] 1138871003815 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 1138871003816 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1138871003817 transcription termination factor Rho; Provisional; Region: PRK12608 1138871003818 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1138871003819 RNA binding site [nucleotide binding]; other site 1138871003820 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1138871003821 multimer interface [polypeptide binding]; other site 1138871003822 Walker A motif; other site 1138871003823 ATP binding site [chemical binding]; other site 1138871003824 Walker B motif; other site 1138871003825 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1138871003826 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1138871003827 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1138871003828 RF-1 domain; Region: RF-1; pfam00472 1138871003829 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1138871003830 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871003831 S-adenosylmethionine binding site [chemical binding]; other site 1138871003832 tRNA threonylcarbamoyl adenosine modification protein, Sua5/YciO/YrdC/YwlC family; Region: TIGR00057 1138871003833 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1138871003834 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1138871003835 Mg++ binding site [ion binding]; other site 1138871003836 putative catalytic motif [active] 1138871003837 substrate binding site [chemical binding]; other site 1138871003838 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1138871003839 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1138871003840 F0F1 ATP synthase subunit C; Validated; Region: PRK05880 1138871003841 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1138871003842 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1138871003843 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428 1138871003844 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1138871003845 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 1138871003846 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1138871003847 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1138871003848 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1138871003849 beta subunit interaction interface [polypeptide binding]; other site 1138871003850 Walker A motif; other site 1138871003851 ATP binding site [chemical binding]; other site 1138871003852 Walker B motif; other site 1138871003853 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1138871003854 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1138871003855 core domain interface [polypeptide binding]; other site 1138871003856 delta subunit interface [polypeptide binding]; other site 1138871003857 epsilon subunit interface [polypeptide binding]; other site 1138871003858 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1138871003859 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1138871003860 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1138871003861 alpha subunit interaction interface [polypeptide binding]; other site 1138871003862 Walker A motif; other site 1138871003863 ATP binding site [chemical binding]; other site 1138871003864 Walker B motif; other site 1138871003865 inhibitor binding site; inhibition site 1138871003866 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1138871003867 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1138871003868 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1138871003869 gamma subunit interface [polypeptide binding]; other site 1138871003870 epsilon subunit interface [polypeptide binding]; other site 1138871003871 LBP interface [polypeptide binding]; other site 1138871003872 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 1138871003873 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1138871003874 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1138871003875 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1138871003876 hinge; other site 1138871003877 active site 1138871003878 PE family; Region: PE; pfam00934 1138871003879 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871003880 PPE family; Region: PPE; pfam00823 1138871003881 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138871003882 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1138871003883 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1138871003884 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1138871003885 DNA binding site [nucleotide binding] 1138871003886 active site 1138871003887 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1138871003888 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1138871003889 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1138871003890 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1138871003891 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1138871003892 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1138871003893 minor groove reading motif; other site 1138871003894 helix-hairpin-helix signature motif; other site 1138871003895 substrate binding pocket [chemical binding]; other site 1138871003896 active site 1138871003897 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1138871003898 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1138871003899 metal binding site [ion binding]; metal-binding site 1138871003900 active site 1138871003901 I-site; other site 1138871003902 HAMP domain; Region: HAMP; pfam00672 1138871003903 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1138871003904 cyclase homology domain; Region: CHD; cd07302 1138871003905 nucleotidyl binding site; other site 1138871003906 metal binding site [ion binding]; metal-binding site 1138871003907 dimer interface [polypeptide binding]; other site 1138871003908 Predicted nuclease of the RecB family [DNA replication, recombination, and repair]; Region: COG1637 1138871003909 hypothetical protein; Provisional; Region: PRK03298 1138871003910 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1138871003911 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138871003912 dimer interface [polypeptide binding]; other site 1138871003913 substrate binding site [chemical binding]; other site 1138871003914 metal binding site [ion binding]; metal-binding site 1138871003915 putative acyltransferase; Provisional; Region: PRK05790 1138871003916 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138871003917 dimer interface [polypeptide binding]; other site 1138871003918 active site 1138871003919 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1138871003920 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1138871003921 glycogen branching enzyme; Provisional; Region: PRK05402 1138871003922 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1138871003923 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1138871003924 active site 1138871003925 catalytic site [active] 1138871003926 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1138871003927 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1138871003928 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1138871003929 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1138871003930 active site 1138871003931 homodimer interface [polypeptide binding]; other site 1138871003932 catalytic site [active] 1138871003933 acceptor binding site [chemical binding]; other site 1138871003934 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 1138871003935 putative homodimer interface [polypeptide binding]; other site 1138871003936 putative active site pocket [active] 1138871003937 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1138871003938 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1138871003939 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1138871003940 ATP binding site [chemical binding]; other site 1138871003941 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1138871003942 putative Mg++ binding site [ion binding]; other site 1138871003943 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1138871003944 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1138871003945 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1138871003946 active site 1138871003947 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 1138871003948 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 1138871003949 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 1138871003950 putative active site pocket [active] 1138871003951 cleavage site 1138871003952 Rhomboid family; Region: Rhomboid; pfam01694 1138871003953 glutamate racemase; Provisional; Region: PRK00865 1138871003954 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 1138871003955 ribonuclease PH; Reviewed; Region: rph; PRK00173 1138871003956 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1138871003957 hexamer interface [polypeptide binding]; other site 1138871003958 active site 1138871003959 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1138871003960 active site 1138871003961 dimerization interface [polypeptide binding]; other site 1138871003962 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1138871003963 Glucitol operon activator protein (GutM); Region: GutM; cl01890 1138871003964 Argininosuccinate lyase [Amino acid transport and metabolism]; Region: ArgH; COG0165 1138871003965 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 1138871003966 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1138871003967 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1138871003968 FAD binding pocket [chemical binding]; other site 1138871003969 FAD binding motif [chemical binding]; other site 1138871003970 phosphate binding motif [ion binding]; other site 1138871003971 NAD binding pocket [chemical binding]; other site 1138871003972 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1138871003973 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138871003974 Walker A/P-loop; other site 1138871003975 ATP binding site [chemical binding]; other site 1138871003976 Q-loop/lid; other site 1138871003977 ABC transporter signature motif; other site 1138871003978 Walker B; other site 1138871003979 D-loop; other site 1138871003980 H-loop/switch region; other site 1138871003981 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138871003982 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1138871003983 Walker A/P-loop; other site 1138871003984 ATP binding site [chemical binding]; other site 1138871003985 Q-loop/lid; other site 1138871003986 ABC transporter signature motif; other site 1138871003987 Walker B; other site 1138871003988 D-loop; other site 1138871003989 H-loop/switch region; other site 1138871003990 Phosphotransferase enzyme family; Region: APH; pfam01636 1138871003991 Ecdysteroid kinase; Region: EcKinase; cl17738 1138871003992 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1138871003993 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1138871003994 classical (c) SDRs; Region: SDR_c; cd05233 1138871003995 NAD(P) binding site [chemical binding]; other site 1138871003996 active site 1138871003997 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871003998 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871003999 active site 1138871004000 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138871004001 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871004002 NAD(P) binding site [chemical binding]; other site 1138871004003 active site 1138871004004 acetyl-CoA acetyltransferase; Provisional; Region: PRK06205 1138871004005 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138871004006 dimer interface [polypeptide binding]; other site 1138871004007 active site 1138871004008 mesaconyl-CoA isomerase; Region: mesacon_CoA_iso; TIGR04253 1138871004009 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138871004010 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871004011 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871004012 active site 1138871004013 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1138871004014 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138871004015 DNA-binding site [nucleotide binding]; DNA binding site 1138871004016 FCD domain; Region: FCD; pfam07729 1138871004017 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1138871004018 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871004019 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871004020 acyl-activating enzyme (AAE) consensus motif; other site 1138871004021 acyl-activating enzyme (AAE) consensus motif; other site 1138871004022 AMP binding site [chemical binding]; other site 1138871004023 active site 1138871004024 CoA binding site [chemical binding]; other site 1138871004025 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1138871004026 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871004027 acyl-activating enzyme (AAE) consensus motif; other site 1138871004028 AMP binding site [chemical binding]; other site 1138871004029 active site 1138871004030 CoA binding site [chemical binding]; other site 1138871004031 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1138871004032 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871004033 AMP binding site [chemical binding]; other site 1138871004034 active site 1138871004035 acyl-activating enzyme (AAE) consensus motif; other site 1138871004036 CoA binding site [chemical binding]; other site 1138871004037 enoyl-CoA hydratase; Provisional; Region: PRK05981 1138871004038 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138871004039 substrate binding site [chemical binding]; other site 1138871004040 oxyanion hole (OAH) forming residues; other site 1138871004041 trimer interface [polypeptide binding]; other site 1138871004042 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138871004043 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138871004044 substrate binding site [chemical binding]; other site 1138871004045 oxyanion hole (OAH) forming residues; other site 1138871004046 trimer interface [polypeptide binding]; other site 1138871004047 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138871004048 phenylacetate degradation probable enoyl-CoA hydratase paaB; Region: PaaB1; TIGR02280 1138871004049 substrate binding site [chemical binding]; other site 1138871004050 oxyanion hole (OAH) forming residues; other site 1138871004051 trimer interface [polypeptide binding]; other site 1138871004052 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138871004053 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1138871004054 substrate binding site [chemical binding]; other site 1138871004055 oxyanion hole (OAH) forming residues; other site 1138871004056 trimer interface [polypeptide binding]; other site 1138871004057 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1138871004058 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871004059 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1138871004060 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871004061 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138871004062 NAD(P) binding site [chemical binding]; other site 1138871004063 active site 1138871004064 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1138871004065 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1138871004066 active site 1138871004067 inhibitor site; inhibition site 1138871004068 dimer interface [polypeptide binding]; other site 1138871004069 catalytic residue [active] 1138871004070 CsbD-like; Region: CsbD; cl17424 1138871004071 enoyl-CoA hydratase; Provisional; Region: PRK06210 1138871004072 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138871004073 substrate binding site [chemical binding]; other site 1138871004074 oxyanion hole (OAH) forming residues; other site 1138871004075 trimer interface [polypeptide binding]; other site 1138871004076 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138871004077 acyl-CoA synthetase; Validated; Region: PRK07798 1138871004078 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871004079 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 1138871004080 acyl-activating enzyme (AAE) consensus motif; other site 1138871004081 acyl-activating enzyme (AAE) consensus motif; other site 1138871004082 putative AMP binding site [chemical binding]; other site 1138871004083 putative active site [active] 1138871004084 putative CoA binding site [chemical binding]; other site 1138871004085 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138871004086 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1138871004087 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138871004088 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871004089 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871004090 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871004091 active site 1138871004092 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138871004093 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 1138871004094 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138871004095 active site 1138871004096 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138871004097 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138871004098 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871004099 Cytochrome P450; Region: p450; cl12078 1138871004100 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1138871004101 NAD(P) binding site [chemical binding]; other site 1138871004102 catalytic residues [active] 1138871004103 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871004104 Cytochrome P450; Region: p450; cl12078 1138871004105 short chain dehydrogenase; Provisional; Region: PRK07832 1138871004106 classical (c) SDRs; Region: SDR_c; cd05233 1138871004107 NAD(P) binding site [chemical binding]; other site 1138871004108 active site 1138871004109 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1138871004110 hydrophobic ligand binding site; other site 1138871004111 acyl-CoA synthetase; Validated; Region: PRK07798 1138871004112 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871004113 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 1138871004114 acyl-activating enzyme (AAE) consensus motif; other site 1138871004115 acyl-activating enzyme (AAE) consensus motif; other site 1138871004116 putative AMP binding site [chemical binding]; other site 1138871004117 putative active site [active] 1138871004118 putative CoA binding site [chemical binding]; other site 1138871004119 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1138871004120 CoenzymeA binding site [chemical binding]; other site 1138871004121 subunit interaction site [polypeptide binding]; other site 1138871004122 PHB binding site; other site 1138871004123 Isochorismatase family; Region: Isochorismatase; pfam00857 1138871004124 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1138871004125 catalytic triad [active] 1138871004126 conserved cis-peptide bond; other site 1138871004127 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1138871004128 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1138871004129 [2Fe-2S] cluster binding site [ion binding]; other site 1138871004130 SnoaL-like domain; Region: SnoaL_4; pfam13577 1138871004131 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138871004132 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138871004133 SnoaL-like domain; Region: SnoaL_2; pfam12680 1138871004134 probable F420-dependent oxidoreductase, MSMEG_2249 family; Region: F420_MSMEG_2249; TIGR03857 1138871004135 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138871004136 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138871004137 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1138871004138 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1138871004139 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1138871004140 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871004141 Cytochrome P450; Region: p450; cl12078 1138871004142 short chain dehydrogenase; Provisional; Region: PRK06197 1138871004143 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871004144 NAD(P) binding site [chemical binding]; other site 1138871004145 active site 1138871004146 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871004147 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871004148 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138871004149 Walker A/P-loop; other site 1138871004150 ATP binding site [chemical binding]; other site 1138871004151 Predicted membrane protein [Function unknown]; Region: COG1511 1138871004152 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1138871004153 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1138871004154 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1138871004155 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1138871004156 NAD binding site [chemical binding]; other site 1138871004157 catalytic Zn binding site [ion binding]; other site 1138871004158 substrate binding site [chemical binding]; other site 1138871004159 structural Zn binding site [ion binding]; other site 1138871004160 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871004161 Cytochrome P450; Region: p450; cl12078 1138871004162 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1138871004163 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138871004164 substrate binding pocket [chemical binding]; other site 1138871004165 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871004166 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138871004167 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1138871004168 active site 1138871004169 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871004170 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871004171 active site 1138871004172 PAS fold; Region: PAS_4; pfam08448 1138871004173 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1138871004174 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1138871004175 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1138871004176 ATP binding site [chemical binding]; other site 1138871004177 Mg2+ binding site [ion binding]; other site 1138871004178 G-X-G motif; other site 1138871004179 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138871004180 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871004181 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871004182 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1138871004183 CoenzymeA binding site [chemical binding]; other site 1138871004184 subunit interaction site [polypeptide binding]; other site 1138871004185 PHB binding site; other site 1138871004186 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1138871004187 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1138871004188 putative AMP binding site [chemical binding]; other site 1138871004189 putative active site [active] 1138871004190 acyl-activating enzyme (AAE) consensus motif; other site 1138871004191 putative CoA binding site [chemical binding]; other site 1138871004192 Acyl-CoA dehydrogenase, C-terminal domain; Region: Acyl-CoA_dh_1; pfam00441 1138871004193 active site 1138871004194 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871004195 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871004196 active site 1138871004197 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871004198 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871004199 active site 1138871004200 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871004201 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138871004202 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871004203 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1138871004204 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138871004205 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1138871004206 classical (c) SDRs; Region: SDR_c; cd05233 1138871004207 NAD(P) binding site [chemical binding]; other site 1138871004208 active site 1138871004209 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1138871004210 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138871004211 DNA-binding site [nucleotide binding]; DNA binding site 1138871004212 FCD domain; Region: FCD; pfam07729 1138871004213 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138871004214 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138871004215 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138871004216 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138871004217 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1138871004218 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1138871004219 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871004220 Cytochrome P450; Region: p450; cl12078 1138871004221 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1138871004222 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1138871004223 [2Fe-2S] cluster binding site [ion binding]; other site 1138871004224 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1138871004225 hydrophobic ligand binding site; other site 1138871004226 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 1138871004227 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 1138871004228 acyl-activating enzyme (AAE) consensus motif; other site 1138871004229 putative AMP binding site [chemical binding]; other site 1138871004230 putative active site [active] 1138871004231 putative CoA binding site [chemical binding]; other site 1138871004232 SnoaL-like domain; Region: SnoaL_4; pfam13577 1138871004233 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1138871004234 active site 1138871004235 catalytic site [active] 1138871004236 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 1138871004237 putative active site [active] 1138871004238 putative catalytic site [active] 1138871004239 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 1138871004240 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138871004241 NAD binding site [chemical binding]; other site 1138871004242 catalytic residues [active] 1138871004243 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 1138871004244 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1138871004245 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1138871004246 [2Fe-2S] cluster binding site [ion binding]; other site 1138871004247 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_3; cd08887 1138871004248 putative alpha subunit interface [polypeptide binding]; other site 1138871004249 putative active site [active] 1138871004250 putative substrate binding site [chemical binding]; other site 1138871004251 Fe binding site [ion binding]; other site 1138871004252 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1138871004253 non-specific DNA binding site [nucleotide binding]; other site 1138871004254 salt bridge; other site 1138871004255 sequence-specific DNA binding site [nucleotide binding]; other site 1138871004256 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 1138871004257 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1138871004258 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 1138871004259 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1138871004260 phosphate binding site [ion binding]; other site 1138871004261 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 1138871004262 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 1138871004263 putative active site [active] 1138871004264 putative catalytic site [active] 1138871004265 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1138871004266 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1138871004267 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 1138871004268 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 1138871004269 putative NAD(P) binding site [chemical binding]; other site 1138871004270 active site 1138871004271 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 1138871004272 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1138871004273 active site 1138871004274 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1138871004275 hypothetical protein; Provisional; Region: PRK07907 1138871004276 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1138871004277 active site 1138871004278 metal binding site [ion binding]; metal-binding site 1138871004279 dimer interface [polypeptide binding]; other site 1138871004280 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1138871004281 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871004282 Cytochrome P450; Region: p450; cl12078 1138871004283 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1138871004284 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1138871004285 catalytic triad [active] 1138871004286 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 1138871004287 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 1138871004288 hypothetical protein; Provisional; Region: PRK01346 1138871004289 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 1138871004290 MMPL family; Region: MMPL; pfam03176 1138871004291 MMPL family; Region: MMPL; pfam03176 1138871004292 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1138871004293 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1138871004294 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1138871004295 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1138871004296 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1138871004297 catalytic site [active] 1138871004298 putative active site [active] 1138871004299 putative substrate binding site [chemical binding]; other site 1138871004300 dimer interface [polypeptide binding]; other site 1138871004301 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1138871004302 Helix-turn-helix domain; Region: HTH_38; pfam13936 1138871004303 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1138871004304 Integrase core domain; Region: rve; pfam00665 1138871004305 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1138871004306 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871004307 NAD(P) binding site [chemical binding]; other site 1138871004308 active site 1138871004309 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1138871004310 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138871004311 Integrase core domain; Region: rve; pfam00665 1138871004312 Integrase core domain; Region: rve_3; pfam13683 1138871004313 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1138871004314 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1138871004315 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871004316 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871004317 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 1138871004318 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1138871004319 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1138871004320 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1138871004321 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1138871004322 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1138871004323 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1138871004324 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1138871004325 carboxyltransferase (CT) interaction site; other site 1138871004326 biotinylation site [posttranslational modification]; other site 1138871004327 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871004328 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871004329 active site 1138871004330 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1138871004331 putative active site [active] 1138871004332 putative catalytic site [active] 1138871004333 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1138871004334 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1138871004335 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1138871004336 tetramer interface [polypeptide binding]; other site 1138871004337 TPP-binding site [chemical binding]; other site 1138871004338 heterodimer interface [polypeptide binding]; other site 1138871004339 phosphorylation loop region [posttranslational modification] 1138871004340 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1138871004341 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1138871004342 alpha subunit interface [polypeptide binding]; other site 1138871004343 TPP binding site [chemical binding]; other site 1138871004344 heterodimer interface [polypeptide binding]; other site 1138871004345 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1138871004346 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1138871004347 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1138871004348 E3 interaction surface; other site 1138871004349 lipoyl attachment site [posttranslational modification]; other site 1138871004350 e3 binding domain; Region: E3_binding; pfam02817 1138871004351 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1138871004352 enoyl-CoA hydratase; Provisional; Region: PRK05870 1138871004353 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138871004354 substrate binding site [chemical binding]; other site 1138871004355 oxyanion hole (OAH) forming residues; other site 1138871004356 trimer interface [polypeptide binding]; other site 1138871004357 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1138871004358 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1138871004359 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138871004360 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1138871004361 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138871004362 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1138871004363 HAD-superfamily subfamily IB hydrolase, TIGR01490; Region: HAD-SF-IB-hyp1 1138871004364 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1138871004365 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1138871004366 putative acyl-acceptor binding pocket; other site 1138871004367 glycerol-3-phosphate acyltransferase; Validated; Region: PRK03355 1138871004368 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1138871004369 putative acyl-acceptor binding pocket; other site 1138871004370 Copper resistance protein D; Region: CopD; pfam05425 1138871004371 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 1138871004372 Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389 1138871004373 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1138871004374 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1138871004375 dimer interface [polypeptide binding]; other site 1138871004376 ssDNA binding site [nucleotide binding]; other site 1138871004377 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1138871004378 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1138871004379 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138871004380 Walker A/P-loop; other site 1138871004381 ATP binding site [chemical binding]; other site 1138871004382 Q-loop/lid; other site 1138871004383 ABC transporter signature motif; other site 1138871004384 Walker B; other site 1138871004385 D-loop; other site 1138871004386 H-loop/switch region; other site 1138871004387 ABC transporter; Region: ABC_tran_2; pfam12848 1138871004388 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1138871004389 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 1138871004390 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1138871004391 active site 1138871004392 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138871004393 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1138871004394 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1138871004395 active site 1138871004396 catalytic site [active] 1138871004397 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1138871004398 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1138871004399 apolar tunnel; other site 1138871004400 heme binding site [chemical binding]; other site 1138871004401 dimerization interface [polypeptide binding]; other site 1138871004402 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1138871004403 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138871004404 active site 1138871004405 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1138871004406 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1138871004407 Zn binding site [ion binding]; other site 1138871004408 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1138871004409 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1138871004410 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1138871004411 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 1138871004412 putative DNA binding site [nucleotide binding]; other site 1138871004413 catalytic residue [active] 1138871004414 putative H2TH interface [polypeptide binding]; other site 1138871004415 putative catalytic residues [active] 1138871004416 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1138871004417 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1138871004418 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1138871004419 Beta-lactamase; Region: Beta-lactamase; pfam00144 1138871004420 trigger factor; Provisional; Region: tig; PRK01490 1138871004421 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1138871004422 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1138871004423 Clp protease; Region: CLP_protease; pfam00574 1138871004424 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1138871004425 oligomer interface [polypeptide binding]; other site 1138871004426 active site residues [active] 1138871004427 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1138871004428 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1138871004429 oligomer interface [polypeptide binding]; other site 1138871004430 active site residues [active] 1138871004431 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1138871004432 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1138871004433 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1138871004434 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1138871004435 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138871004436 Walker A motif; other site 1138871004437 ATP binding site [chemical binding]; other site 1138871004438 Walker B motif; other site 1138871004439 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1138871004440 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1138871004441 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138871004442 putative substrate translocation pore; other site 1138871004443 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1138871004444 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1138871004445 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1138871004446 dimer interface [polypeptide binding]; other site 1138871004447 PYR/PP interface [polypeptide binding]; other site 1138871004448 TPP binding site [chemical binding]; other site 1138871004449 substrate binding site [chemical binding]; other site 1138871004450 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1138871004451 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1138871004452 TPP-binding site [chemical binding]; other site 1138871004453 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1138871004454 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1138871004455 GTP binding site; other site 1138871004456 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1138871004457 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1138871004458 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1138871004459 NAD(P) binding pocket [chemical binding]; other site 1138871004460 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1138871004461 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1138871004462 active site 1138871004463 HIGH motif; other site 1138871004464 nucleotide binding site [chemical binding]; other site 1138871004465 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1138871004466 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1138871004467 active site 1138871004468 KMSKS motif; other site 1138871004469 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1138871004470 tRNA binding surface [nucleotide binding]; other site 1138871004471 anticodon binding site; other site 1138871004472 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1138871004473 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1138871004474 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1138871004475 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 1138871004476 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1138871004477 active site 1138871004478 multimer interface [polypeptide binding]; other site 1138871004479 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1138871004480 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1138871004481 homodimer interface [polypeptide binding]; other site 1138871004482 oligonucleotide binding site [chemical binding]; other site 1138871004483 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1138871004484 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1138871004485 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1138871004486 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1138871004487 GTP1/OBG; Region: GTP1_OBG; pfam01018 1138871004488 Obg GTPase; Region: Obg; cd01898 1138871004489 G1 box; other site 1138871004490 GTP/Mg2+ binding site [chemical binding]; other site 1138871004491 Switch I region; other site 1138871004492 G2 box; other site 1138871004493 G3 box; other site 1138871004494 Switch II region; other site 1138871004495 G4 box; other site 1138871004496 G5 box; other site 1138871004497 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1138871004498 gamma-glutamyl kinase; Provisional; Region: PRK05429 1138871004499 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1138871004500 nucleotide binding site [chemical binding]; other site 1138871004501 homotetrameric interface [polypeptide binding]; other site 1138871004502 putative phosphate binding site [ion binding]; other site 1138871004503 putative allosteric binding site; other site 1138871004504 PUA domain; Region: PUA; pfam01472 1138871004505 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871004506 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871004507 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871004508 Cytochrome P450; Region: p450; cl12078 1138871004509 NAD-dependent deacetylase; Provisional; Region: PRK00481 1138871004510 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 1138871004511 NAD+ binding site [chemical binding]; other site 1138871004512 substrate binding site [chemical binding]; other site 1138871004513 Zn binding site [ion binding]; other site 1138871004514 Isochorismatase family; Region: Isochorismatase; pfam00857 1138871004515 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1138871004516 catalytic triad [active] 1138871004517 conserved cis-peptide bond; other site 1138871004518 NAD synthetase; Reviewed; Region: nadE; PRK02628 1138871004519 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1138871004520 multimer interface [polypeptide binding]; other site 1138871004521 active site 1138871004522 catalytic triad [active] 1138871004523 protein interface 1 [polypeptide binding]; other site 1138871004524 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1138871004525 homodimer interface [polypeptide binding]; other site 1138871004526 NAD binding pocket [chemical binding]; other site 1138871004527 ATP binding pocket [chemical binding]; other site 1138871004528 Mg binding site [ion binding]; other site 1138871004529 active-site loop [active] 1138871004530 Integrase core domain; Region: rve; pfam00665 1138871004531 Integrase core domain; Region: rve_3; pfam13683 1138871004532 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1138871004533 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1138871004534 substrate binding site [chemical binding]; other site 1138871004535 ATP binding site [chemical binding]; other site 1138871004536 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1138871004537 dimerization interface [polypeptide binding]; other site 1138871004538 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1138871004539 cyclase homology domain; Region: CHD; cd07302 1138871004540 nucleotidyl binding site; other site 1138871004541 metal binding site [ion binding]; metal-binding site 1138871004542 dimer interface [polypeptide binding]; other site 1138871004543 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1138871004544 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1138871004545 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1138871004546 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1138871004547 ligand binding site [chemical binding]; other site 1138871004548 flexible hinge region; other site 1138871004549 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1138871004550 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1138871004551 putative catalytic cysteine [active] 1138871004552 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1138871004553 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138871004554 Walker A motif; other site 1138871004555 ATP binding site [chemical binding]; other site 1138871004556 Walker B motif; other site 1138871004557 arginine finger; other site 1138871004558 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 1138871004559 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1138871004560 metal ion-dependent adhesion site (MIDAS); other site 1138871004561 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1138871004562 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1138871004563 active site 1138871004564 (T/H)XGH motif; other site 1138871004565 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1138871004566 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1138871004567 catalytic core [active] 1138871004568 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1138871004569 active site 1138871004570 catalytic triad [active] 1138871004571 oxyanion hole [active] 1138871004572 EDD domain protein, DegV family; Region: DegV; TIGR00762 1138871004573 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1138871004574 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1138871004575 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1138871004576 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138871004577 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1138871004578 acyl-CoA synthetase; Validated; Region: PRK05850 1138871004579 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1138871004580 acyl-activating enzyme (AAE) consensus motif; other site 1138871004581 active site 1138871004582 PE-PPE domain; Region: PE-PPE; pfam08237 1138871004583 Transport protein; Region: actII; TIGR00833 1138871004584 peptide synthase; Provisional; Region: PRK12316 1138871004585 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138871004586 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1138871004587 active site 1138871004588 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1138871004589 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1138871004590 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1138871004591 KR domain; Region: KR; pfam08659 1138871004592 putative NADP binding site [chemical binding]; other site 1138871004593 active site 1138871004594 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138871004595 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138871004596 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1138871004597 active site 1138871004598 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1138871004599 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1138871004600 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1138871004601 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871004602 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1138871004603 Enoylreductase; Region: PKS_ER; smart00829 1138871004604 NAD(P) binding site [chemical binding]; other site 1138871004605 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1138871004606 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1138871004607 putative NADP binding site [chemical binding]; other site 1138871004608 active site 1138871004609 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138871004610 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1138871004611 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1138871004612 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138871004613 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1138871004614 active site 1138871004615 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1138871004616 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1138871004617 FAD binding site [chemical binding]; other site 1138871004618 substrate binding site [chemical binding]; other site 1138871004619 catalytic base [active] 1138871004620 comEA protein; Region: comE; TIGR01259 1138871004621 Helix-hairpin-helix motif; Region: HHH; pfam00633 1138871004622 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1138871004623 Competence protein; Region: Competence; pfam03772 1138871004624 hypothetical protein; Reviewed; Region: PRK07914 1138871004625 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1138871004626 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1138871004627 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1138871004628 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1138871004629 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1138871004630 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1138871004631 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1138871004632 ribonuclease Z; Reviewed; Region: PRK00055 1138871004633 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 1138871004634 FOG: CBS domain [General function prediction only]; Region: COG0517 1138871004635 PemK-like protein; Region: PemK; pfam02452 1138871004636 GTP-binding protein LepA; Provisional; Region: PRK05433 1138871004637 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1138871004638 putative GEF interaction site [polypeptide binding]; other site 1138871004639 Switch I region; other site 1138871004640 G2 box; other site 1138871004641 G3 box; other site 1138871004642 Switch II region; other site 1138871004643 GTP/Mg2+ binding site [chemical binding]; other site 1138871004644 G4 box; other site 1138871004645 G5 box; other site 1138871004646 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1138871004647 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1138871004648 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1138871004649 PknH-like extracellular domain; Region: PknH_C; pfam14032 1138871004650 PknH-like extracellular domain; Region: PknH_C; pfam14032 1138871004651 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1138871004652 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1138871004653 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1138871004654 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1138871004655 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1138871004656 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138871004657 dimer interface [polypeptide binding]; other site 1138871004658 conserved gate region; other site 1138871004659 putative PBP binding loops; other site 1138871004660 ABC-ATPase subunit interface; other site 1138871004661 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1138871004662 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138871004663 dimer interface [polypeptide binding]; other site 1138871004664 conserved gate region; other site 1138871004665 putative PBP binding loops; other site 1138871004666 ABC-ATPase subunit interface; other site 1138871004667 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1138871004668 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 1138871004669 Walker A/P-loop; other site 1138871004670 ATP binding site [chemical binding]; other site 1138871004671 Q-loop/lid; other site 1138871004672 ABC transporter signature motif; other site 1138871004673 Walker B; other site 1138871004674 D-loop; other site 1138871004675 H-loop/switch region; other site 1138871004676 TOBE domain; Region: TOBE; pfam03459 1138871004677 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1138871004678 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1138871004679 Active Sites [active] 1138871004680 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1138871004681 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1138871004682 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1138871004683 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1138871004684 HemN C-terminal domain; Region: HemN_C; pfam06969 1138871004685 Predicted permease [General function prediction only]; Region: COG3329 1138871004686 salicylate synthase MbtI; Reviewed; Region: PRK07912 1138871004687 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1138871004688 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg2; cd04778 1138871004689 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1138871004690 DNA binding residues [nucleotide binding] 1138871004691 putative dimer interface [polypeptide binding]; other site 1138871004692 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138871004693 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138871004694 classical (c) SDRs; Region: SDR_c; cd05233 1138871004695 short chain dehydrogenase; Provisional; Region: PRK05650 1138871004696 NAD(P) binding site [chemical binding]; other site 1138871004697 active site 1138871004698 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1138871004699 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1138871004700 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1138871004701 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1138871004702 NAD binding site [chemical binding]; other site 1138871004703 catalytic Zn binding site [ion binding]; other site 1138871004704 substrate binding site [chemical binding]; other site 1138871004705 structural Zn binding site [ion binding]; other site 1138871004706 aldehyde dehydrogenase, Rv0768 family; Region: aldehy_Rv0768; TIGR04284 1138871004707 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1138871004708 NAD binding site [chemical binding]; other site 1138871004709 catalytic residues [active] 1138871004710 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1138871004711 classical (c) SDRs; Region: SDR_c; cd05233 1138871004712 NAD(P) binding site [chemical binding]; other site 1138871004713 active site 1138871004714 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138871004715 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871004716 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871004717 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1138871004718 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1138871004719 ligand binding site [chemical binding]; other site 1138871004720 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138871004721 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1138871004722 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871004723 Cytochrome P450; Region: p450; cl12078 1138871004724 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138871004725 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138871004726 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871004727 NAD(P) binding site [chemical binding]; other site 1138871004728 active site 1138871004729 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1138871004730 classical (c) SDRs; Region: SDR_c; cd05233 1138871004731 NAD(P) binding site [chemical binding]; other site 1138871004732 active site 1138871004733 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138871004734 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138871004735 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1138871004736 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871004737 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871004738 acyl-activating enzyme (AAE) consensus motif; other site 1138871004739 acyl-activating enzyme (AAE) consensus motif; other site 1138871004740 AMP binding site [chemical binding]; other site 1138871004741 active site 1138871004742 CoA binding site [chemical binding]; other site 1138871004743 SnoaL-like domain; Region: SnoaL_4; pfam13577 1138871004744 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138871004745 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138871004746 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871004747 Cytochrome P450; Region: p450; cl12078 1138871004748 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1138871004749 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1138871004750 NAD(P) binding site [chemical binding]; other site 1138871004751 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138871004752 active site 1138871004753 metal binding site [ion binding]; metal-binding site 1138871004754 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase_4; pfam13669 1138871004755 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1138871004756 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138871004757 classical (c) SDRs; Region: SDR_c; cd05233 1138871004758 NAD(P) binding site [chemical binding]; other site 1138871004759 active site 1138871004760 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1138871004761 classical (c) SDRs; Region: SDR_c; cd05233 1138871004762 NAD(P) binding site [chemical binding]; other site 1138871004763 active site 1138871004764 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1138871004765 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871004766 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871004767 lipid-transfer protein; Provisional; Region: PRK07855 1138871004768 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138871004769 active site 1138871004770 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 1138871004771 putative active site [active] 1138871004772 putative catalytic site [active] 1138871004773 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871004774 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871004775 active site 1138871004776 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1138871004777 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1138871004778 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138871004779 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1138871004780 active site 1138871004781 catalytic site [active] 1138871004782 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871004783 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871004784 active site 1138871004785 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871004786 Cytochrome P450; Region: p450; cl12078 1138871004787 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138871004788 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like and related proteins; Region: ALDH_CddD-AldA-like; cd07089 1138871004789 NAD binding site [chemical binding]; other site 1138871004790 catalytic residues [active] 1138871004791 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138871004792 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138871004793 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138871004794 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138871004795 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1138871004796 putative active site [active] 1138871004797 putative catalytic site [active] 1138871004798 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138871004799 Isochorismatase family; Region: Isochorismatase; pfam00857 1138871004800 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1138871004801 catalytic triad [active] 1138871004802 conserved cis-peptide bond; other site 1138871004803 SnoaL-like domain; Region: SnoaL_4; pfam13577 1138871004804 SnoaL-like domain; Region: SnoaL_3; pfam13474 1138871004805 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1138871004806 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138871004807 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871004808 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138871004809 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1138871004810 active site 1138871004811 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138871004812 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138871004813 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 1138871004814 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871004815 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871004816 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871004817 active site 1138871004818 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 1138871004819 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 1138871004820 acyl-activating enzyme (AAE) consensus motif; other site 1138871004821 putative AMP binding site [chemical binding]; other site 1138871004822 putative active site [active] 1138871004823 putative CoA binding site [chemical binding]; other site 1138871004824 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138871004825 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1138871004826 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871004827 NAD(P) binding site [chemical binding]; other site 1138871004828 active site 1138871004829 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871004830 active site 1138871004831 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1138871004832 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871004833 acyl-activating enzyme (AAE) consensus motif; other site 1138871004834 AMP binding site [chemical binding]; other site 1138871004835 active site 1138871004836 CoA binding site [chemical binding]; other site 1138871004837 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138871004838 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138871004839 substrate binding site [chemical binding]; other site 1138871004840 oxyanion hole (OAH) forming residues; other site 1138871004841 trimer interface [polypeptide binding]; other site 1138871004842 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138871004843 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138871004844 substrate binding site [chemical binding]; other site 1138871004845 oxyanion hole (OAH) forming residues; other site 1138871004846 trimer interface [polypeptide binding]; other site 1138871004847 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871004848 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1138871004849 active site 1138871004850 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138871004851 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138871004852 substrate binding site [chemical binding]; other site 1138871004853 oxyanion hole (OAH) forming residues; other site 1138871004854 trimer interface [polypeptide binding]; other site 1138871004855 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1138871004856 active site 2 [active] 1138871004857 active site 1 [active] 1138871004858 enoyl-CoA hydratase; Provisional; Region: PRK06688 1138871004859 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138871004860 substrate binding site [chemical binding]; other site 1138871004861 oxyanion hole (OAH) forming residues; other site 1138871004862 trimer interface [polypeptide binding]; other site 1138871004863 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1138871004864 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 1138871004865 NAD binding site [chemical binding]; other site 1138871004866 homodimer interface [polypeptide binding]; other site 1138871004867 active site 1138871004868 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1138871004869 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871004870 acyl-activating enzyme (AAE) consensus motif; other site 1138871004871 AMP binding site [chemical binding]; other site 1138871004872 active site 1138871004873 CoA binding site [chemical binding]; other site 1138871004874 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1138871004875 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138871004876 thiolase; Provisional; Region: PRK06158 1138871004877 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138871004878 active site 1138871004879 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1138871004880 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1138871004881 active site 1138871004882 iron coordination sites [ion binding]; other site 1138871004883 substrate binding pocket [chemical binding]; other site 1138871004884 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1138871004885 glycerate dehydrogenase; Provisional; Region: PRK06487 1138871004886 ligand binding site [chemical binding]; other site 1138871004887 NAD binding site [chemical binding]; other site 1138871004888 dimerization interface [polypeptide binding]; other site 1138871004889 catalytic site [active] 1138871004890 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138871004891 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138871004892 substrate binding site [chemical binding]; other site 1138871004893 oxyanion hole (OAH) forming residues; other site 1138871004894 trimer interface [polypeptide binding]; other site 1138871004895 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138871004896 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871004897 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871004898 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871004899 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871004900 active site 1138871004901 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138871004902 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871004903 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871004904 active site 1138871004905 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1138871004906 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1138871004907 CoenzymeA binding site [chemical binding]; other site 1138871004908 subunit interaction site [polypeptide binding]; other site 1138871004909 PHB binding site; other site 1138871004910 enoyl-CoA hydratase; Provisional; Region: PRK08290 1138871004911 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138871004912 substrate binding site [chemical binding]; other site 1138871004913 oxyanion hole (OAH) forming residues; other site 1138871004914 trimer interface [polypeptide binding]; other site 1138871004915 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138871004916 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1138871004917 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1138871004918 FMN binding site [chemical binding]; other site 1138871004919 dimer interface [polypeptide binding]; other site 1138871004920 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871004921 Cytochrome P450; Region: p450; cl12078 1138871004922 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1138871004923 FMN binding site [chemical binding]; other site 1138871004924 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1138871004925 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138871004926 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1138871004927 MarR family; Region: MarR_2; pfam12802 1138871004928 Predicted transcriptional regulator [Transcription]; Region: COG2345 1138871004929 Hemerythrin-like domain; Region: Hr-like; cd12108 1138871004930 Fe binding site [ion binding]; other site 1138871004931 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 1138871004932 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1138871004933 Hemerythrin-like domain; Region: Hr-like; cd12108 1138871004934 OsmC-like protein; Region: OsmC; cl00767 1138871004935 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1138871004936 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1138871004937 active site pocket [active] 1138871004938 aconitate hydratase; Validated; Region: PRK09277 1138871004939 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1138871004940 substrate binding site [chemical binding]; other site 1138871004941 ligand binding site [chemical binding]; other site 1138871004942 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1138871004943 substrate binding site [chemical binding]; other site 1138871004944 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1138871004945 dimer interface [polypeptide binding]; other site 1138871004946 Predicted transcriptional regulator [Transcription]; Region: COG2345 1138871004947 HTH domain; Region: HTH_11; pfam08279 1138871004948 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1138871004949 heme-binding site [chemical binding]; other site 1138871004950 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 1138871004951 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1138871004952 catalytic loop [active] 1138871004953 iron binding site [ion binding]; other site 1138871004954 Cupin domain; Region: Cupin_2; pfam07883 1138871004955 Ferredoxin [Energy production and conversion]; Region: COG1146 1138871004956 4Fe-4S binding domain; Region: Fer4; pfam00037 1138871004957 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1138871004958 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1138871004959 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1138871004960 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1138871004961 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1138871004962 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 1138871004963 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 1138871004964 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1138871004965 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1138871004966 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1138871004967 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1138871004968 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 1138871004969 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 1138871004970 Binuclear center (active site) [active] 1138871004971 K-pathway; other site 1138871004972 Putative proton exit pathway; other site 1138871004973 Hemerythrin-like domain; Region: Hr-like; cd12108 1138871004974 Fe binding site [ion binding]; other site 1138871004975 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871004976 PPE family; Region: PPE; pfam00823 1138871004977 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138871004978 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1138871004979 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1138871004980 Condensation domain; Region: Condensation; pfam00668 1138871004981 malate dehydrogenase; Provisional; Region: PRK13529 1138871004982 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1138871004983 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1138871004984 NAD(P) binding site [chemical binding]; other site 1138871004985 Flavodoxin; Region: Flavodoxin_1; pfam00258 1138871004986 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1138871004987 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1138871004988 FAD binding pocket [chemical binding]; other site 1138871004989 FAD binding motif [chemical binding]; other site 1138871004990 catalytic residues [active] 1138871004991 NAD binding pocket [chemical binding]; other site 1138871004992 phosphate binding motif [ion binding]; other site 1138871004993 beta-alpha-beta structure motif; other site 1138871004994 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1138871004995 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1138871004996 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871004997 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1138871004998 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1138871004999 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1138871005000 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1138871005001 acyl-activating enzyme (AAE) consensus motif; other site 1138871005002 active site 1138871005003 AMP binding site [chemical binding]; other site 1138871005004 substrate binding site [chemical binding]; other site 1138871005005 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1138871005006 Condensation domain; Region: Condensation; pfam00668 1138871005007 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138871005008 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1138871005009 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1138871005010 acyl-activating enzyme (AAE) consensus motif; other site 1138871005011 AMP binding site [chemical binding]; other site 1138871005012 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138871005013 Thioesterase domain; Region: Thioesterase; pfam00975 1138871005014 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138871005015 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1138871005016 active site 1138871005017 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1138871005018 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1138871005019 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 1138871005020 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1138871005021 NADP binding site [chemical binding]; other site 1138871005022 active site 1138871005023 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138871005024 Condensation domain; Region: Condensation; pfam00668 1138871005025 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138871005026 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138871005027 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138871005028 acyl-activating enzyme (AAE) consensus motif; other site 1138871005029 AMP binding site [chemical binding]; other site 1138871005030 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138871005031 Condensation domain; Region: Condensation; pfam00668 1138871005032 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138871005033 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138871005034 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138871005035 acyl-activating enzyme (AAE) consensus motif; other site 1138871005036 AMP binding site [chemical binding]; other site 1138871005037 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138871005038 Condensation domain; Region: Condensation; pfam00668 1138871005039 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138871005040 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138871005041 acyl-activating enzyme (AAE) consensus motif; other site 1138871005042 AMP binding site [chemical binding]; other site 1138871005043 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1138871005044 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 1138871005045 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138871005046 MbtH-like protein; Region: MbtH; pfam03621 1138871005047 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1138871005048 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1138871005049 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138871005050 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1138871005051 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1138871005052 Transcription regulator of the Arc/MetJ class [Transcription]; Region: COG5450 1138871005053 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1138871005054 HTH domain; Region: HTH_11; cl17392 1138871005055 chaperone protein DnaJ; Provisional; Region: PRK14278 1138871005056 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1138871005057 HSP70 interaction site [polypeptide binding]; other site 1138871005058 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1138871005059 Zn binding sites [ion binding]; other site 1138871005060 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1138871005061 dimer interface [polypeptide binding]; other site 1138871005062 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1138871005063 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1138871005064 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl17245 1138871005065 PhoH-like protein; Region: PhoH; pfam02562 1138871005066 metal-binding heat shock protein; Provisional; Region: PRK00016 1138871005067 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1138871005068 Domain of unknown function DUF21; Region: DUF21; pfam01595 1138871005069 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1138871005070 Transporter associated domain; Region: CorC_HlyC; smart01091 1138871005071 GTPase Era; Reviewed; Region: era; PRK00089 1138871005072 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1138871005073 G1 box; other site 1138871005074 GTP/Mg2+ binding site [chemical binding]; other site 1138871005075 Switch I region; other site 1138871005076 G2 box; other site 1138871005077 Switch II region; other site 1138871005078 G3 box; other site 1138871005079 G4 box; other site 1138871005080 G5 box; other site 1138871005081 KH domain; Region: KH_2; pfam07650 1138871005082 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1138871005083 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1138871005084 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138871005085 catalytic residue [active] 1138871005086 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1138871005087 amidase; Provisional; Region: PRK06061 1138871005088 Amidase; Region: Amidase; pfam01425 1138871005089 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1138871005090 Recombination protein O N terminal; Region: RecO_N; pfam11967 1138871005091 Recombination protein O C terminal; Region: RecO_C; pfam02565 1138871005092 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1138871005093 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1138871005094 catalytic residue [active] 1138871005095 putative FPP diphosphate binding site; other site 1138871005096 putative FPP binding hydrophobic cleft; other site 1138871005097 dimer interface [polypeptide binding]; other site 1138871005098 putative IPP diphosphate binding site; other site 1138871005099 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1138871005100 metal binding site 2 [ion binding]; metal-binding site 1138871005101 putative DNA binding helix; other site 1138871005102 metal binding site 1 [ion binding]; metal-binding site 1138871005103 dimer interface [polypeptide binding]; other site 1138871005104 structural Zn2+ binding site [ion binding]; other site 1138871005105 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1138871005106 dimerization interface [polypeptide binding]; other site 1138871005107 putative DNA binding site [nucleotide binding]; other site 1138871005108 putative Zn2+ binding site [ion binding]; other site 1138871005109 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1138871005110 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1138871005111 motif 1; other site 1138871005112 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1138871005113 active site 1138871005114 motif 2; other site 1138871005115 motif 3; other site 1138871005116 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1138871005117 anticodon binding site; other site 1138871005118 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871005119 PPE family; Region: PPE; pfam00823 1138871005120 Repair protein; Region: Repair_PSII; pfam04536 1138871005121 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 1138871005122 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1138871005123 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1138871005124 Copper/zinc superoxide dismutase (SODC); Region: Sod_Cu; pfam00080 1138871005125 E-class dimer interface [polypeptide binding]; other site 1138871005126 P-class dimer interface [polypeptide binding]; other site 1138871005127 active site 1138871005128 Cu2+ binding site [ion binding]; other site 1138871005129 Zn2+ binding site [ion binding]; other site 1138871005130 DNA primase; Validated; Region: dnaG; PRK05667 1138871005131 CHC2 zinc finger; Region: zf-CHC2; cl17510 1138871005132 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1138871005133 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1138871005134 active site 1138871005135 metal binding site [ion binding]; metal-binding site 1138871005136 interdomain interaction site; other site 1138871005137 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1138871005138 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; smart00766 1138871005139 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1138871005140 active site 1138871005141 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1138871005142 non-prolyl cis peptide bond; other site 1138871005143 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1138871005144 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1138871005145 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138871005146 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1138871005147 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 1138871005148 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1138871005149 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1138871005150 trimer interface [polypeptide binding]; other site 1138871005151 active site 1138871005152 substrate binding site [chemical binding]; other site 1138871005153 CoA binding site [chemical binding]; other site 1138871005154 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1138871005155 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1138871005156 dimer interface [polypeptide binding]; other site 1138871005157 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138871005158 catalytic residue [active] 1138871005159 Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601 1138871005160 Stf0 sulphotransferase; Region: Sulphotransf; pfam09037 1138871005161 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1138871005162 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1138871005163 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1138871005164 [4Fe-4S] binding site [ion binding]; other site 1138871005165 molybdopterin cofactor binding site; other site 1138871005166 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1138871005167 molybdopterin cofactor binding site; other site 1138871005168 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1138871005169 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1138871005170 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1138871005171 FAD binding pocket [chemical binding]; other site 1138871005172 FAD binding motif [chemical binding]; other site 1138871005173 catalytic residues [active] 1138871005174 NAD binding pocket [chemical binding]; other site 1138871005175 phosphate binding motif [ion binding]; other site 1138871005176 beta-alpha-beta structure motif; other site 1138871005177 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1138871005178 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871005179 active site 1138871005180 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138871005181 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1138871005182 Walker A/P-loop; other site 1138871005183 ATP binding site [chemical binding]; other site 1138871005184 Q-loop/lid; other site 1138871005185 ABC transporter signature motif; other site 1138871005186 Walker B; other site 1138871005187 D-loop; other site 1138871005188 H-loop/switch region; other site 1138871005189 MarR family; Region: MarR; pfam01047 1138871005190 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1138871005191 PMP-22/EMP/MP20/Claudin family; Region: PMP22_Claudin; cl17758 1138871005192 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13644 1138871005193 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1138871005194 Walker A/P-loop; other site 1138871005195 ATP binding site [chemical binding]; other site 1138871005196 Q-loop/lid; other site 1138871005197 ABC transporter signature motif; other site 1138871005198 Walker B; other site 1138871005199 D-loop; other site 1138871005200 H-loop/switch region; other site 1138871005201 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1138871005202 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1138871005203 Walker A/P-loop; other site 1138871005204 ATP binding site [chemical binding]; other site 1138871005205 Q-loop/lid; other site 1138871005206 ABC transporter signature motif; other site 1138871005207 Walker B; other site 1138871005208 D-loop; other site 1138871005209 H-loop/switch region; other site 1138871005210 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1138871005211 amino acid transporter; Region: 2A0306; TIGR00909 1138871005212 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1138871005213 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1138871005214 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1138871005215 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1138871005216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138871005217 dimer interface [polypeptide binding]; other site 1138871005218 conserved gate region; other site 1138871005219 putative PBP binding loops; other site 1138871005220 ABC-ATPase subunit interface; other site 1138871005221 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1138871005222 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138871005223 dimer interface [polypeptide binding]; other site 1138871005224 conserved gate region; other site 1138871005225 putative PBP binding loops; other site 1138871005226 ABC-ATPase subunit interface; other site 1138871005227 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1138871005228 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1138871005229 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1138871005230 Helix-turn-helix domain; Region: HTH_28; pfam13518 1138871005231 Winged helix-turn helix; Region: HTH_29; pfam13551 1138871005232 Homeodomain-like domain; Region: HTH_32; pfam13565 1138871005233 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1138871005234 Integrase core domain; Region: rve; pfam00665 1138871005235 Integrase core domain; Region: rve_3; pfam13683 1138871005236 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138871005237 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1138871005238 catalytic site [active] 1138871005239 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 1138871005240 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1138871005241 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138871005242 ABC transporter signature motif; other site 1138871005243 Walker B; other site 1138871005244 D-loop; other site 1138871005245 H-loop/switch region; other site 1138871005246 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1138871005247 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1138871005248 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138871005249 NAD(P) binding site [chemical binding]; other site 1138871005250 catalytic residues [active] 1138871005251 Repair protein; Region: Repair_PSII; pfam04536 1138871005252 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 1138871005253 AAA domain; Region: AAA_33; pfam13671 1138871005254 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1138871005255 active site 1138871005256 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 1138871005257 catalytic triad [active] 1138871005258 active site nucleophile [active] 1138871005259 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1138871005260 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 1138871005261 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1138871005262 cyclase homology domain; Region: CHD; cd07302 1138871005263 nucleotidyl binding site; other site 1138871005264 metal binding site [ion binding]; metal-binding site 1138871005265 dimer interface [polypeptide binding]; other site 1138871005266 Predicted ATPase [General function prediction only]; Region: COG3899 1138871005267 AAA ATPase domain; Region: AAA_16; pfam13191 1138871005268 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1138871005269 GAF domain; Region: GAF; pfam01590 1138871005270 GAF domain; Region: GAF_3; pfam13492 1138871005271 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1138871005272 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1138871005273 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1138871005274 ATP binding site [chemical binding]; other site 1138871005275 Mg2+ binding site [ion binding]; other site 1138871005276 G-X-G motif; other site 1138871005277 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1138871005278 anti sigma factor interaction site; other site 1138871005279 regulatory phosphorylation site [posttranslational modification]; other site 1138871005280 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1138871005281 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138871005282 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138871005283 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871005284 S-adenosylmethionine binding site [chemical binding]; other site 1138871005285 CCC1-related family of proteins; Region: CCC1_like; cl00278 1138871005286 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1138871005287 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1138871005288 active site 2 [active] 1138871005289 active site 1 [active] 1138871005290 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1138871005291 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 1138871005292 acyl-activating enzyme (AAE) consensus motif; other site 1138871005293 putative AMP binding site [chemical binding]; other site 1138871005294 putative active site [active] 1138871005295 putative CoA binding site [chemical binding]; other site 1138871005296 Helix-turn-helix domain; Region: HTH_38; pfam13936 1138871005297 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1138871005298 Integrase core domain; Region: rve; pfam00665 1138871005299 TIGR03085 family protein; Region: TIGR03085 1138871005300 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1138871005301 heat shock protein 90; Provisional; Region: PRK05218 1138871005302 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138871005303 ATP binding site [chemical binding]; other site 1138871005304 Mg2+ binding site [ion binding]; other site 1138871005305 G-X-G motif; other site 1138871005306 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1138871005307 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138871005308 PknH-like extracellular domain; Region: PknH_C; pfam14032 1138871005309 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 1138871005310 dimer interface [polypeptide binding]; other site 1138871005311 ligand binding site [chemical binding]; other site 1138871005312 Predicted membrane protein [Function unknown]; Region: COG4270 1138871005313 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1138871005314 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1138871005315 NAD binding site [chemical binding]; other site 1138871005316 catalytic Zn binding site [ion binding]; other site 1138871005317 substrate binding site [chemical binding]; other site 1138871005318 structural Zn binding site [ion binding]; other site 1138871005319 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138871005320 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 1138871005321 dimer interface [polypeptide binding]; other site 1138871005322 active site 1138871005323 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1138871005324 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1138871005325 active site 1138871005326 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1138871005327 Integrase core domain; Region: rve; pfam00665 1138871005328 Integrase core domain; Region: rve_3; pfam13683 1138871005329 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1138871005330 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1138871005331 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1138871005332 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1138871005333 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1138871005334 MarR family; Region: MarR; pfam01047 1138871005335 haloalkane dehalogenase; Provisional; Region: PRK00870 1138871005336 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 1138871005337 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1138871005338 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1138871005339 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138871005340 homodimer interface [polypeptide binding]; other site 1138871005341 catalytic residue [active] 1138871005342 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1138871005343 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138871005344 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138871005345 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1138871005346 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1138871005347 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871005348 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871005349 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871005350 Cytochrome P450; Region: p450; cl12078 1138871005351 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138871005352 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138871005353 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1138871005354 dimerization interface [polypeptide binding]; other site 1138871005355 putative DNA binding site [nucleotide binding]; other site 1138871005356 putative Zn2+ binding site [ion binding]; other site 1138871005357 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 1138871005358 arsenical-resistance protein; Region: acr3; TIGR00832 1138871005359 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1138871005360 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1138871005361 active site 1138871005362 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 1138871005363 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138871005364 putative metal binding site [ion binding]; other site 1138871005365 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1138871005366 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1138871005367 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1138871005368 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871005369 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871005370 Cytochrome P450; Region: p450; cl12078 1138871005371 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1138871005372 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1138871005373 active site residue [active] 1138871005374 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1138871005375 active site residue [active] 1138871005376 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1138871005377 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1138871005378 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1138871005379 hypothetical protein; Provisional; Region: PRK08244 1138871005380 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1138871005381 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1138871005382 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871005383 Predicted ATPase [General function prediction only]; Region: COG4637 1138871005384 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138871005385 Walker A/P-loop; other site 1138871005386 ATP binding site [chemical binding]; other site 1138871005387 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1138871005388 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 1138871005389 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1138871005390 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1138871005391 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138871005392 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 1138871005393 4Fe-4S binding domain; Region: Fer4; cl02805 1138871005394 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1138871005395 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1138871005396 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1138871005397 dimerization interface [polypeptide binding]; other site 1138871005398 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1138871005399 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1138871005400 putative active site [active] 1138871005401 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1138871005402 putative active site [active] 1138871005403 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 1138871005404 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1138871005405 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1138871005406 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1138871005407 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138871005408 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138871005409 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871005410 Cytochrome P450; Region: p450; cl12078 1138871005411 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871005412 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871005413 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871005414 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871005415 Domain of unknown function (DUF385); Region: DUF385; cl04387 1138871005416 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1138871005417 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1138871005418 FAD binding domain; Region: FAD_binding_4; pfam01565 1138871005419 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1138871005420 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1138871005421 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1138871005422 active site 1138871005423 ATP binding site [chemical binding]; other site 1138871005424 substrate binding site [chemical binding]; other site 1138871005425 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1138871005426 activation loop (A-loop); other site 1138871005427 activation loop (A-loop); other site 1138871005428 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1138871005429 2TM domain; Region: 2TM; pfam13239 1138871005430 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871005431 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871005432 WHG domain; Region: WHG; pfam13305 1138871005433 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871005434 Cytochrome P450; Region: p450; cl12078 1138871005435 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138871005436 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1138871005437 active site 1138871005438 metal binding site [ion binding]; metal-binding site 1138871005439 Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337 1138871005440 MIT_C; domain found C-terminal to MIT (contained within Microtubule Interacting and Trafficking molecules) domains, as well as in some bacterial proteins. The function of this domain is unknown; Region: MIT_C; cd02685 1138871005441 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1138871005442 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 1138871005443 putative active site [active] 1138871005444 putative NTP binding site [chemical binding]; other site 1138871005445 putative nucleic acid binding site [nucleotide binding]; other site 1138871005446 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1138871005447 active site 1138871005448 catalytic triad [active] 1138871005449 dimer interface [polypeptide binding]; other site 1138871005450 TIGR02687 family protein; Region: TIGR02687 1138871005451 PglZ domain; Region: PglZ; pfam08665 1138871005452 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1138871005453 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 1138871005454 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 1138871005455 Domain of unknown function (DUF1788); Region: DUF1788; pfam08747 1138871005456 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 1138871005457 DNA binding domain, excisionase family; Region: excise; TIGR01764 1138871005458 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1138871005459 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1138871005460 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1138871005461 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1138871005462 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1138871005463 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1138871005464 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1138871005465 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871005466 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871005467 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871005468 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871005469 active site 1138871005470 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1138871005471 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1138871005472 active site 1138871005473 metal binding site [ion binding]; metal-binding site 1138871005474 Cutinase; Region: Cutinase; pfam01083 1138871005475 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138871005476 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138871005477 Septum formation; Region: Septum_form; pfam13845 1138871005478 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1138871005479 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871005480 Cytochrome P450; Region: p450; cl12078 1138871005481 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1138871005482 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138871005483 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1138871005484 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1138871005485 SAM dependent carboxyl methyltransferase; Region: Methyltransf_7; cl04109 1138871005486 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1138871005487 S-(hydroxymethyl)mycothiol dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 1138871005488 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1138871005489 NAD binding site [chemical binding]; other site 1138871005490 catalytic Zn binding site [ion binding]; other site 1138871005491 substrate binding site [chemical binding]; other site 1138871005492 structural Zn binding site [ion binding]; other site 1138871005493 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1138871005494 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871005495 S-adenosylmethionine binding site [chemical binding]; other site 1138871005496 Beta-lactamase; Region: Beta-lactamase; pfam00144 1138871005497 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1138871005498 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 1138871005499 diacylglycerol kinase; Reviewed; Region: PRK11914 1138871005500 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1138871005501 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1138871005502 FAD binding domain; Region: FAD_binding_4; pfam01565 1138871005503 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871005504 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871005505 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 1138871005506 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1138871005507 nucleoside/Zn binding site; other site 1138871005508 dimer interface [polypeptide binding]; other site 1138871005509 catalytic motif [active] 1138871005510 hypothetical protein; Provisional; Region: PRK06126 1138871005511 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1138871005512 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1138871005513 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1138871005514 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1138871005515 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 1138871005516 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1138871005517 dimer interface [polypeptide binding]; other site 1138871005518 active site 1138871005519 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 1138871005520 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1138871005521 dimer interface [polypeptide binding]; other site 1138871005522 active site 1138871005523 acyl carrier protein; Provisional; Region: acpP; PRK00982 1138871005524 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1138871005525 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1138871005526 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1138871005527 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1138871005528 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1138871005529 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1138871005530 dimer interface [polypeptide binding]; other site 1138871005531 TPP-binding site [chemical binding]; other site 1138871005532 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1138871005533 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1138871005534 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 1138871005535 dimer interface [polypeptide binding]; other site 1138871005536 catalytic triad [active] 1138871005537 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 1138871005538 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1138871005539 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138871005540 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1138871005541 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138871005542 active site 1138871005543 metal binding site [ion binding]; metal-binding site 1138871005544 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1138871005545 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 1138871005546 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1138871005547 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1138871005548 active site 1138871005549 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1138871005550 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138871005551 motif II; other site 1138871005552 hypothetical protein; Provisional; Region: PRK07908 1138871005553 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1138871005554 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138871005555 catalytic residue [active] 1138871005556 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1138871005557 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1138871005558 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1138871005559 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1138871005560 Putative zinc ribbon domain; Region: DUF164; pfam02591 1138871005561 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 1138871005562 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1138871005563 RNA/DNA hybrid binding site [nucleotide binding]; other site 1138871005564 active site 1138871005565 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1138871005566 catalytic core [active] 1138871005567 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 1138871005568 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138871005569 Helix-turn-helix domain; Region: HTH_18; pfam12833 1138871005570 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1138871005571 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1138871005572 sequence-specific DNA binding site [nucleotide binding]; other site 1138871005573 salt bridge; other site 1138871005574 Cupin domain; Region: Cupin_2; pfam07883 1138871005575 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871005576 S-adenosylmethionine binding site [chemical binding]; other site 1138871005577 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 1138871005578 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 1138871005579 putative active site; other site 1138871005580 putative metal binding residues [ion binding]; other site 1138871005581 signature motif; other site 1138871005582 putative triphosphate binding site [ion binding]; other site 1138871005583 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 1138871005584 hypothetical protein; Provisional; Region: PRK06185 1138871005585 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 1138871005586 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1138871005587 oligomerization interface [polypeptide binding]; other site 1138871005588 active site 1138871005589 metal binding site [ion binding]; metal-binding site 1138871005590 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1138871005591 TAP-like protein; Region: Abhydrolase_4; pfam08386 1138871005592 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1138871005593 TAP-like protein; Region: Abhydrolase_4; pfam08386 1138871005594 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1138871005595 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1138871005596 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1138871005597 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1138871005598 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1138871005599 metal binding triad; other site 1138871005600 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1138871005601 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1138871005602 metal binding triad; other site 1138871005603 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1138871005604 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1138871005605 CoenzymeA binding site [chemical binding]; other site 1138871005606 subunit interaction site [polypeptide binding]; other site 1138871005607 PHB binding site; other site 1138871005608 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1138871005609 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138871005610 MarR family; Region: MarR_2; pfam12802 1138871005611 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871005612 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1138871005613 NAD(P) binding site [chemical binding]; other site 1138871005614 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1138871005615 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871005616 active site 1138871005617 Fic/DOC family; Region: Fic; pfam02661 1138871005618 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1138871005619 Helix-turn-helix domain; Region: HTH_17; pfam12728 1138871005620 D5 N terminal like; Region: D5_N; pfam08706 1138871005621 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 1138871005622 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 1138871005623 polymerase nucleotide-binding site; other site 1138871005624 DNA-binding residues [nucleotide binding]; DNA binding site 1138871005625 nucleotide binding site [chemical binding]; other site 1138871005626 primase nucleotide-binding site [nucleotide binding]; other site 1138871005627 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1138871005628 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1138871005629 non-specific DNA binding site [nucleotide binding]; other site 1138871005630 salt bridge; other site 1138871005631 sequence-specific DNA binding site [nucleotide binding]; other site 1138871005632 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1138871005633 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1138871005634 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1138871005635 active site 1138871005636 DNA binding site [nucleotide binding] 1138871005637 Int/Topo IB signature motif; other site 1138871005638 glutamine synthetase, type I; Region: GlnA; TIGR00653 1138871005639 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1138871005640 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1138871005641 RDD family; Region: RDD; pfam06271 1138871005642 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1138871005643 lipoyl synthase; Provisional; Region: PRK05481 1138871005644 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1138871005645 FeS/SAM binding site; other site 1138871005646 lipoate-protein ligase B; Provisional; Region: PRK14345 1138871005647 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1138871005648 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1138871005649 putative NAD(P) binding site [chemical binding]; other site 1138871005650 putative active site [active] 1138871005651 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1138871005652 E3 interaction surface; other site 1138871005653 lipoyl attachment site [posttranslational modification]; other site 1138871005654 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1138871005655 E3 interaction surface; other site 1138871005656 lipoyl attachment site [posttranslational modification]; other site 1138871005657 e3 binding domain; Region: E3_binding; pfam02817 1138871005658 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 1138871005659 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1138871005660 short chain dehydrogenase; Validated; Region: PRK05855 1138871005661 classical (c) SDRs; Region: SDR_c; cd05233 1138871005662 NAD(P) binding site [chemical binding]; other site 1138871005663 active site 1138871005664 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1138871005665 hydrophobic ligand binding site; other site 1138871005666 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1138871005667 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138871005668 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1138871005669 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1138871005670 interface (dimer of trimers) [polypeptide binding]; other site 1138871005671 Substrate-binding/catalytic site; other site 1138871005672 Zn-binding sites [ion binding]; other site 1138871005673 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1138871005674 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1138871005675 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1138871005676 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1138871005677 homodimer interface [polypeptide binding]; other site 1138871005678 substrate-cofactor binding pocket; other site 1138871005679 catalytic residue [active] 1138871005680 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1138871005681 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 1138871005682 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1138871005683 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1138871005684 putative dimer interface [polypeptide binding]; other site 1138871005685 active site pocket [active] 1138871005686 putative cataytic base [active] 1138871005687 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1138871005688 homotrimer interface [polypeptide binding]; other site 1138871005689 Walker A motif; other site 1138871005690 GTP binding site [chemical binding]; other site 1138871005691 Walker B motif; other site 1138871005692 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1138871005693 Glycerate kinase family; Region: Gly_kinase; pfam02595 1138871005694 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1138871005695 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 1138871005696 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1138871005697 substrate binding site [chemical binding]; other site 1138871005698 ATP binding site [chemical binding]; other site 1138871005699 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1138871005700 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1138871005701 active site 1138871005702 dimer interface [polypeptide binding]; other site 1138871005703 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1138871005704 Ligand Binding Site [chemical binding]; other site 1138871005705 Molecular Tunnel; other site 1138871005706 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1138871005707 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1138871005708 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 1138871005709 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1138871005710 Protein of unknown function (DUF2561); Region: DUF2561; pfam10812 1138871005711 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1138871005712 heme bH binding site [chemical binding]; other site 1138871005713 intrachain domain interface; other site 1138871005714 heme bL binding site [chemical binding]; other site 1138871005715 interchain domain interface [polypeptide binding]; other site 1138871005716 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 1138871005717 Qo binding site; other site 1138871005718 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1138871005719 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1138871005720 iron-sulfur cluster [ion binding]; other site 1138871005721 [2Fe-2S] cluster binding site [ion binding]; other site 1138871005722 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1138871005723 Cytochrome c; Region: Cytochrom_C; pfam00034 1138871005724 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1138871005725 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 1138871005726 Subunit I/III interface [polypeptide binding]; other site 1138871005727 hypothetical protein; Validated; Region: PRK07883 1138871005728 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1138871005729 active site 1138871005730 catalytic site [active] 1138871005731 substrate binding site [chemical binding]; other site 1138871005732 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1138871005733 GIY-YIG motif/motif A; other site 1138871005734 active site 1138871005735 catalytic site [active] 1138871005736 putative DNA binding site [nucleotide binding]; other site 1138871005737 metal binding site [ion binding]; metal-binding site 1138871005738 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1138871005739 NlpC/P60 family; Region: NLPC_P60; pfam00877 1138871005740 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1138871005741 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1138871005742 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1138871005743 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1138871005744 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1138871005745 acyl-activating enzyme (AAE) consensus motif; other site 1138871005746 putative AMP binding site [chemical binding]; other site 1138871005747 putative active site [active] 1138871005748 putative CoA binding site [chemical binding]; other site 1138871005749 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1138871005750 putative hydrophobic ligand binding site [chemical binding]; other site 1138871005751 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1138871005752 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1138871005753 DTAP/Switch II; other site 1138871005754 Switch I; other site 1138871005755 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1138871005756 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1138871005757 putative acyl-acceptor binding pocket; other site 1138871005758 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1138871005759 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1138871005760 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1138871005761 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1138871005762 active site 1138871005763 ATP binding site [chemical binding]; other site 1138871005764 substrate binding site [chemical binding]; other site 1138871005765 activation loop (A-loop); other site 1138871005766 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1138871005767 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1138871005768 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1138871005769 substrate binding pocket [chemical binding]; other site 1138871005770 chain length determination region; other site 1138871005771 substrate-Mg2+ binding site; other site 1138871005772 catalytic residues [active] 1138871005773 aspartate-rich region 1; other site 1138871005774 active site lid residues [active] 1138871005775 aspartate-rich region 2; other site 1138871005776 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1138871005777 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 1138871005778 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 1138871005779 MraZ protein; Region: MraZ; pfam02381 1138871005780 MraZ protein; Region: MraZ; pfam02381 1138871005781 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1138871005782 MraW methylase family; Region: Methyltransf_5; cl17771 1138871005783 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1138871005784 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1138871005785 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1138871005786 hypothetical protein; Provisional; Region: PRK07236 1138871005787 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871005788 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871005789 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1138871005790 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1138871005791 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1138871005792 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1138871005793 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1138871005794 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1138871005795 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1138871005796 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1138871005797 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1138871005798 Mg++ binding site [ion binding]; other site 1138871005799 putative catalytic motif [active] 1138871005800 putative substrate binding site [chemical binding]; other site 1138871005801 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03369 1138871005802 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1138871005803 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1138871005804 cell division protein FtsW; Region: ftsW; TIGR02614 1138871005805 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1138871005806 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1138871005807 active site 1138871005808 homodimer interface [polypeptide binding]; other site 1138871005809 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1138871005810 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1138871005811 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1138871005812 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1138871005813 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1138871005814 Cell division protein FtsQ; Region: FtsQ; pfam03799 1138871005815 cell division protein FtsZ; Validated; Region: PRK09330 1138871005816 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1138871005817 nucleotide binding site [chemical binding]; other site 1138871005818 SulA interaction site; other site 1138871005819 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1138871005820 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 1138871005821 Predicted enzyme with a TIM-barrel fold [General function prediction only]; Region: COG0325 1138871005822 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1138871005823 catalytic residue [active] 1138871005824 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1138871005825 Predicted integral membrane protein [Function unknown]; Region: COG0762 1138871005826 DivIVA domain; Region: DivI1A_domain; TIGR03544 1138871005827 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1138871005828 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1138871005829 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1138871005830 active site 1138871005831 Divergent AAA domain; Region: AAA_4; pfam04326 1138871005832 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1138871005833 putative active site [active] 1138871005834 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1138871005835 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1138871005836 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138871005837 Walker A motif; other site 1138871005838 ATP binding site [chemical binding]; other site 1138871005839 Walker B motif; other site 1138871005840 Homeodomain-like domain; Region: HTH_23; pfam13384 1138871005841 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1138871005842 Integrase core domain; Region: rve; pfam00665 1138871005843 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1138871005844 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1138871005845 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1138871005846 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cd05188 1138871005847 NAD(P) binding site [chemical binding]; other site 1138871005848 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 1138871005849 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138871005850 active site 1138871005851 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871005852 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1138871005853 CoenzymeA binding site [chemical binding]; other site 1138871005854 subunit interaction site [polypeptide binding]; other site 1138871005855 PHB binding site; other site 1138871005856 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138871005857 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138871005858 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871005859 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871005860 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1138871005861 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1138871005862 MULE transposase domain; Region: MULE; pfam10551 1138871005863 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1138871005864 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 1138871005865 Transposase domain (DUF772); Region: DUF772; pfam05598 1138871005866 short chain dehydrogenase; Provisional; Region: PRK07832 1138871005867 classical (c) SDRs; Region: SDR_c; cd05233 1138871005868 NAD(P) binding site [chemical binding]; other site 1138871005869 active site 1138871005870 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1138871005871 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1138871005872 MULE transposase domain; Region: MULE; pfam10551 1138871005873 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1138871005874 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1138871005875 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1138871005876 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1138871005877 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1138871005878 MULE transposase domain; Region: MULE; pfam10551 1138871005879 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1138871005880 DNA-binding interface [nucleotide binding]; DNA binding site 1138871005881 Helix-turn-helix domain; Region: HTH_38; pfam13936 1138871005882 Winged helix-turn helix; Region: HTH_29; pfam13551 1138871005883 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1138871005884 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1138871005885 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1138871005886 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1138871005887 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138871005888 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138871005889 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1138871005890 MULE transposase domain; Region: MULE; pfam10551 1138871005891 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138871005892 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1138871005893 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1138871005894 Permease; Region: Permease; pfam02405 1138871005895 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1138871005896 Permease; Region: Permease; pfam02405 1138871005897 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138871005898 mce related protein; Region: MCE; pfam02470 1138871005899 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1138871005900 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138871005901 mce related protein; Region: MCE; pfam02470 1138871005902 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 1138871005903 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138871005904 mce related protein; Region: MCE; pfam02470 1138871005905 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138871005906 mce related protein; Region: MCE; pfam02470 1138871005907 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138871005908 mce related protein; Region: MCE; pfam02470 1138871005909 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1138871005910 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871005911 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871005912 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1138871005913 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1138871005914 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1138871005915 Helix-turn-helix domain; Region: HTH_28; pfam13518 1138871005916 Winged helix-turn helix; Region: HTH_29; pfam13551 1138871005917 Homeodomain-like domain; Region: HTH_32; pfam13565 1138871005918 Integrase core domain; Region: rve; pfam00665 1138871005919 Integrase core domain; Region: rve_3; pfam13683 1138871005920 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 1138871005921 AAA domain; Region: AAA_22; pfam13401 1138871005922 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1138871005923 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1138871005924 classical (c) SDRs; Region: SDR_c; cd05233 1138871005925 NAD(P) binding site [chemical binding]; other site 1138871005926 active site 1138871005927 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138871005928 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138871005929 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138871005930 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138871005931 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138871005932 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138871005933 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138871005934 3-epi-6-deoxocathasterone 23-monooxygenase; Provisional; Region: PLN03141 1138871005935 Cytochrome P450; Region: p450; cl12078 1138871005936 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1138871005937 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1138871005938 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1138871005939 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 1138871005940 dimer interface [polypeptide binding]; other site 1138871005941 acyl-activating enzyme (AAE) consensus motif; other site 1138871005942 putative active site [active] 1138871005943 AMP binding site [chemical binding]; other site 1138871005944 putative CoA binding site [chemical binding]; other site 1138871005945 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871005946 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871005947 active site 1138871005948 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1138871005949 Creatinine amidohydrolase; Region: Creatininase; pfam02633 1138871005950 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 1138871005951 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1138871005952 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138871005953 hypothetical protein; Provisional; Region: PRK07906 1138871005954 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 1138871005955 putative metal binding site [ion binding]; other site 1138871005956 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1138871005957 substrate binding site [chemical binding]; other site 1138871005958 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1138871005959 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1138871005960 quinone interaction residues [chemical binding]; other site 1138871005961 active site 1138871005962 catalytic residues [active] 1138871005963 FMN binding site [chemical binding]; other site 1138871005964 substrate binding site [chemical binding]; other site 1138871005965 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1138871005966 catalytic core [active] 1138871005967 Protein of unknown function (DUF3090); Region: DUF3090; pfam11290 1138871005968 conserved hypothetical protein; Region: TIGR03843 1138871005969 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1138871005970 active site 1138871005971 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 1138871005972 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1138871005973 active site 1138871005974 HIGH motif; other site 1138871005975 nucleotide binding site [chemical binding]; other site 1138871005976 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1138871005977 active site 1138871005978 KMSKS motif; other site 1138871005979 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 1138871005980 putative tRNA binding surface [nucleotide binding]; other site 1138871005981 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138871005982 Walker A/P-loop; other site 1138871005983 ATP binding site [chemical binding]; other site 1138871005984 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1138871005985 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1138871005986 DNA binding residues [nucleotide binding] 1138871005987 dimerization interface [polypeptide binding]; other site 1138871005988 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138871005989 Walker A motif; other site 1138871005990 ATP binding site [chemical binding]; other site 1138871005991 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1138871005992 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1138871005993 DNA binding residues [nucleotide binding] 1138871005994 dimerization interface [polypeptide binding]; other site 1138871005995 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138871005996 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1138871005997 acyl-activating enzyme (AAE) consensus motif; other site 1138871005998 AMP binding site [chemical binding]; other site 1138871005999 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138871006000 Condensation domain; Region: Condensation; pfam00668 1138871006001 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138871006002 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138871006003 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138871006004 acyl-activating enzyme (AAE) consensus motif; other site 1138871006005 AMP binding site [chemical binding]; other site 1138871006006 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138871006007 Condensation domain; Region: Condensation; pfam00668 1138871006008 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138871006009 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138871006010 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138871006011 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1138871006012 acyl-activating enzyme (AAE) consensus motif; other site 1138871006013 AMP binding site [chemical binding]; other site 1138871006014 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1138871006015 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871006016 S-adenosylmethionine binding site [chemical binding]; other site 1138871006017 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871006018 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138871006019 Condensation domain; Region: Condensation; pfam00668 1138871006020 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138871006021 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138871006022 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871006023 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138871006024 AMP binding site [chemical binding]; other site 1138871006025 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138871006026 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1138871006027 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138871006028 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138871006029 acyl-activating enzyme (AAE) consensus motif; other site 1138871006030 AMP binding site [chemical binding]; other site 1138871006031 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138871006032 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138871006033 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1138871006034 putative substrate translocation pore; other site 1138871006035 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1138871006036 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138871006037 active site 1138871006038 Acyl transferase domain; Region: Acyl_transf_1; pfam00698 1138871006039 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1138871006040 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871006041 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1138871006042 Enoylreductase; Region: PKS_ER; smart00829 1138871006043 NAD(P) binding site [chemical binding]; other site 1138871006044 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1138871006045 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1138871006046 putative NADP binding site [chemical binding]; other site 1138871006047 active site 1138871006048 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138871006049 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871006050 Cytochrome P450; Region: p450; cl12078 1138871006051 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1138871006052 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1138871006053 FAD binding pocket [chemical binding]; other site 1138871006054 FAD binding motif [chemical binding]; other site 1138871006055 phosphate binding motif [ion binding]; other site 1138871006056 NAD binding pocket [chemical binding]; other site 1138871006057 acyl-CoA synthetase; Validated; Region: PRK05850 1138871006058 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1138871006059 acyl-activating enzyme (AAE) consensus motif; other site 1138871006060 active site 1138871006061 short chain dehydrogenase; Provisional; Region: PRK05872 1138871006062 classical (c) SDRs; Region: SDR_c; cd05233 1138871006063 NAD(P) binding site [chemical binding]; other site 1138871006064 active site 1138871006065 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1138871006066 PAC2 family; Region: PAC2; pfam09754 1138871006067 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1138871006068 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1138871006069 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1138871006070 substrate binding pocket [chemical binding]; other site 1138871006071 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1138871006072 B12 binding site [chemical binding]; other site 1138871006073 cobalt ligand [ion binding]; other site 1138871006074 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1138871006075 Mannan-binding protein; Region: MVL; pfam12151 1138871006076 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1138871006077 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138871006078 mce related protein; Region: MCE; pfam02470 1138871006079 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138871006080 mce related protein; Region: MCE; pfam02470 1138871006081 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138871006082 mce related protein; Region: MCE; pfam02470 1138871006083 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1138871006084 mce related protein; Region: MCE; pfam02470 1138871006085 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1138871006086 mce related protein; Region: MCE; pfam02470 1138871006087 mce related protein; Region: MCE; pfam02470 1138871006088 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1138871006089 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1138871006090 Permease; Region: Permease; pfam02405 1138871006091 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1138871006092 Permease; Region: Permease; pfam02405 1138871006093 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1138871006094 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871006095 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1138871006096 homodimer interface [polypeptide binding]; other site 1138871006097 putative metal binding site [ion binding]; other site 1138871006098 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1138871006099 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1138871006100 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1138871006101 Predicted membrane protein [Function unknown]; Region: COG3918 1138871006102 mercuric reductase; Validated; Region: PRK06370 1138871006103 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1138871006104 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138871006105 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1138871006106 RecB family exonuclease [DNA replication, recombination, and repair]; Region: COG2887 1138871006107 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1138871006108 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871006109 S-adenosylmethionine binding site [chemical binding]; other site 1138871006110 Protein of unknown function (DUF503); Region: DUF503; cl00669 1138871006111 proteasome ATPase; Region: pup_AAA; TIGR03689 1138871006112 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138871006113 Walker A motif; other site 1138871006114 ATP binding site [chemical binding]; other site 1138871006115 Walker B motif; other site 1138871006116 arginine finger; other site 1138871006117 proteasome accessory factor PafA2; Region: pupylate_PafA2; TIGR03688 1138871006118 Pup-like protein; Region: Pup; cl05289 1138871006119 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 1138871006120 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1138871006121 active site 1138871006122 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 1138871006123 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 1138871006124 active site 1138871006125 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 1138871006126 Predicted transcriptional regulator [Transcription]; Region: COG2378 1138871006127 WYL domain; Region: WYL; pfam13280 1138871006128 Predicted transcriptional regulator [Transcription]; Region: COG2378 1138871006129 WYL domain; Region: WYL; pfam13280 1138871006130 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 1138871006131 mttA/Hcf106 family; Region: MttA_Hcf106; pfam02416 1138871006132 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1138871006133 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 1138871006134 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1138871006135 ATP binding site [chemical binding]; other site 1138871006136 putative Mg++ binding site [ion binding]; other site 1138871006137 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1138871006138 nucleotide binding region [chemical binding]; other site 1138871006139 ATP-binding site [chemical binding]; other site 1138871006140 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1138871006141 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1138871006142 5'-3' exonuclease; Region: 53EXOc; smart00475 1138871006143 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1138871006144 active site 1138871006145 metal binding site 1 [ion binding]; metal-binding site 1138871006146 putative 5' ssDNA interaction site; other site 1138871006147 metal binding site 3; metal-binding site 1138871006148 metal binding site 2 [ion binding]; metal-binding site 1138871006149 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1138871006150 putative DNA binding site [nucleotide binding]; other site 1138871006151 putative metal binding site [ion binding]; other site 1138871006152 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1138871006153 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1138871006154 active site 1138871006155 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1138871006156 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871006157 NAD(P) binding site [chemical binding]; other site 1138871006158 active site 1138871006159 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1138871006160 active site 1138871006161 putative homodimer interface [polypeptide binding]; other site 1138871006162 SAM binding site [chemical binding]; other site 1138871006163 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1138871006164 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871006165 S-adenosylmethionine binding site [chemical binding]; other site 1138871006166 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1138871006167 active site 1138871006168 SAM binding site [chemical binding]; other site 1138871006169 homodimer interface [polypeptide binding]; other site 1138871006170 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 1138871006171 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1138871006172 Predicted integral membrane protein [Function unknown]; Region: COG5660 1138871006173 Putative zinc-finger; Region: zf-HC2; pfam13490 1138871006174 Predicted integral membrane protein (DUF2275); Region: DUF2275; pfam10039 1138871006175 RNA polymerase sigma factor SigC; Reviewed; Region: PRK09649 1138871006176 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138871006177 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138871006178 DNA binding residues [nucleotide binding] 1138871006179 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871006180 PPE family; Region: PPE; pfam00823 1138871006181 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1138871006182 active site 1138871006183 SAM binding site [chemical binding]; other site 1138871006184 homodimer interface [polypeptide binding]; other site 1138871006185 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1138871006186 active site 1138871006187 SAM binding site [chemical binding]; other site 1138871006188 homodimer interface [polypeptide binding]; other site 1138871006189 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 1138871006190 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1138871006191 precorrin-3B synthase; Region: CobG; TIGR02435 1138871006192 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1138871006193 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138871006194 dimer interface [polypeptide binding]; other site 1138871006195 conserved gate region; other site 1138871006196 putative PBP binding loops; other site 1138871006197 ABC-ATPase subunit interface; other site 1138871006198 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1138871006199 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1138871006200 Walker A/P-loop; other site 1138871006201 ATP binding site [chemical binding]; other site 1138871006202 Q-loop/lid; other site 1138871006203 ABC transporter signature motif; other site 1138871006204 Walker B; other site 1138871006205 D-loop; other site 1138871006206 H-loop/switch region; other site 1138871006207 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1138871006208 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138871006209 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1138871006210 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1138871006211 Moco binding site; other site 1138871006212 metal coordination site [ion binding]; other site 1138871006213 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 1138871006214 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1138871006215 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 1138871006216 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138871006217 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871006218 NAD(P) binding site [chemical binding]; other site 1138871006219 active site 1138871006220 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871006221 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871006222 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 1138871006223 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1138871006224 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1138871006225 phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463 1138871006226 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1138871006227 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1138871006228 active site 1138871006229 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 1138871006230 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1138871006231 putative active site [active] 1138871006232 catalytic triad [active] 1138871006233 putative dimer interface [polypeptide binding]; other site 1138871006234 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1138871006235 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1138871006236 Ligand binding site; other site 1138871006237 Putative Catalytic site; other site 1138871006238 DXD motif; other site 1138871006239 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1138871006240 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1138871006241 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138871006242 active site 1138871006243 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1138871006244 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1138871006245 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871006246 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1138871006247 Enoylreductase; Region: PKS_ER; smart00829 1138871006248 NAD(P) binding site [chemical binding]; other site 1138871006249 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1138871006250 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1138871006251 putative NADP binding site [chemical binding]; other site 1138871006252 active site 1138871006253 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138871006254 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1138871006255 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138871006256 active site 1138871006257 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1138871006258 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1138871006259 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871006260 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1138871006261 Enoylreductase; Region: PKS_ER; smart00829 1138871006262 NAD(P) binding site [chemical binding]; other site 1138871006263 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1138871006264 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1138871006265 putative NADP binding site [chemical binding]; other site 1138871006266 active site 1138871006267 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138871006268 hypothetical protein; Provisional; Region: PRK05865 1138871006269 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871006270 NAD(P) binding site [chemical binding]; other site 1138871006271 active site 1138871006272 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1138871006273 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871006274 Cytochrome P450; Region: p450; cl12078 1138871006275 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871006276 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1138871006277 NAD(P) binding site [chemical binding]; other site 1138871006278 active site 1138871006279 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138871006280 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1138871006281 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1138871006282 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 1138871006283 Walker A motif; other site 1138871006284 ATP binding site [chemical binding]; other site 1138871006285 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 1138871006286 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1138871006287 metal ion-dependent adhesion site (MIDAS); other site 1138871006288 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138871006289 short chain dehydrogenase; Provisional; Region: PRK07814 1138871006290 classical (c) SDRs; Region: SDR_c; cd05233 1138871006291 NAD(P) binding site [chemical binding]; other site 1138871006292 active site 1138871006293 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1138871006294 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138871006295 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1138871006296 classical (c) SDRs; Region: SDR_c; cd05233 1138871006297 NAD(P) binding site [chemical binding]; other site 1138871006298 active site 1138871006299 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871006300 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871006301 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871006302 Cytochrome P450; Region: p450; cl12078 1138871006303 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1138871006304 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1138871006305 substrate binding pocket [chemical binding]; other site 1138871006306 catalytic triad [active] 1138871006307 Phosphotransferase enzyme family; Region: APH; pfam01636 1138871006308 Ecdysteroid kinase; Region: EcKinase; cl17738 1138871006309 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 1138871006310 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1138871006311 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 1138871006312 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 1138871006313 AAA domain; Region: AAA_33; pfam13671 1138871006314 Predicted membrane protein [Function unknown]; Region: COG2259 1138871006315 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1138871006316 catalytic triad [active] 1138871006317 conserved cis-peptide bond; other site 1138871006318 Nuclear transport factor 2 (NTF2) domain; Region: NTF2; pfam02136 1138871006319 DoxX-like family; Region: DoxX_2; pfam13564 1138871006320 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1138871006321 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138871006322 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1138871006323 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1138871006324 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1138871006325 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138871006326 dimer interface [polypeptide binding]; other site 1138871006327 conserved gate region; other site 1138871006328 putative PBP binding loops; other site 1138871006329 ABC-ATPase subunit interface; other site 1138871006330 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1138871006331 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138871006332 dimer interface [polypeptide binding]; other site 1138871006333 conserved gate region; other site 1138871006334 putative PBP binding loops; other site 1138871006335 ABC-ATPase subunit interface; other site 1138871006336 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1138871006337 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1138871006338 Walker A/P-loop; other site 1138871006339 ATP binding site [chemical binding]; other site 1138871006340 Q-loop/lid; other site 1138871006341 ABC transporter signature motif; other site 1138871006342 Walker B; other site 1138871006343 D-loop; other site 1138871006344 H-loop/switch region; other site 1138871006345 TOBE domain; Region: TOBE_2; pfam08402 1138871006346 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1138871006347 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1138871006348 nucleophile elbow; other site 1138871006349 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1138871006350 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 1138871006351 Iron permease FTR1 family; Region: FTR1; cl00475 1138871006352 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 1138871006353 Imelysin; Region: Peptidase_M75; pfam09375 1138871006354 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 1138871006355 OsmC-like protein; Region: OsmC; pfam02566 1138871006356 cyanate hydratase; Validated; Region: PRK02866 1138871006357 Helix-turn-helix domain; Region: HTH_19; pfam12844 1138871006358 non-specific DNA binding site [nucleotide binding]; other site 1138871006359 salt bridge; other site 1138871006360 sequence-specific DNA binding site [nucleotide binding]; other site 1138871006361 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 1138871006362 oligomer interface [polypeptide binding]; other site 1138871006363 active site 1138871006364 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871006365 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871006366 RNA polymerase sigma-70 factor, TIGR02943 family; Region: Sig70_famx1 1138871006367 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1138871006368 DNA binding residues [nucleotide binding] 1138871006369 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1138871006370 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1138871006371 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1138871006372 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1138871006373 active site 1138871006374 catalytic tetrad [active] 1138871006375 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1138871006376 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 1138871006377 putative NADP binding site [chemical binding]; other site 1138871006378 putative substrate binding site [chemical binding]; other site 1138871006379 active site 1138871006380 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1138871006381 extended (e) SDRs; Region: SDR_e; cd08946 1138871006382 NAD(P) binding site [chemical binding]; other site 1138871006383 active site 1138871006384 substrate binding site [chemical binding]; other site 1138871006385 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871006386 active site 1138871006387 SnoaL-like domain; Region: SnoaL_4; pfam13577 1138871006388 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1138871006389 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1138871006390 active site 2 [active] 1138871006391 active site 1 [active] 1138871006392 Uncharacterized conserved protein [Function unknown]; Region: COG5649 1138871006393 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871006394 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871006395 active site 1138871006396 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 1138871006397 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138871006398 3beta17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 3beta-17beta-HSD_like_SDR_c; cd05341 1138871006399 homotetramer interface [polypeptide binding]; other site 1138871006400 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138871006401 NAD binding site [chemical binding]; other site 1138871006402 homodimer interface [polypeptide binding]; other site 1138871006403 active site 1138871006404 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1138871006405 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1138871006406 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1138871006407 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871006408 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138871006409 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138871006410 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138871006411 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138871006412 substrate binding site [chemical binding]; other site 1138871006413 oxyanion hole (OAH) forming residues; other site 1138871006414 trimer interface [polypeptide binding]; other site 1138871006415 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1138871006416 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1138871006417 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1138871006418 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1138871006419 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1138871006420 active site 1138871006421 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1138871006422 catalytic triad [active] 1138871006423 dimer interface [polypeptide binding]; other site 1138871006424 Predicted transcriptional regulator [Transcription]; Region: COG2378 1138871006425 HTH domain; Region: HTH_11; pfam08279 1138871006426 WYL domain; Region: WYL; pfam13280 1138871006427 SnoaL-like domain; Region: SnoaL_2; pfam12680 1138871006428 choline dehydrogenase; Validated; Region: PRK02106 1138871006429 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 1138871006430 active site 1138871006431 Phosphotransferase enzyme family; Region: APH; pfam01636 1138871006432 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1138871006433 active site 1138871006434 substrate binding site [chemical binding]; other site 1138871006435 ATP binding site [chemical binding]; other site 1138871006436 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1138871006437 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1138871006438 potential catalytic triad [active] 1138871006439 conserved cys residue [active] 1138871006440 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138871006441 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138871006442 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871006443 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1138871006444 NAD(P) binding site [chemical binding]; other site 1138871006445 active site 1138871006446 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1138871006447 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138871006448 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138871006449 DNA binding residues [nucleotide binding] 1138871006450 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1138871006451 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 1138871006452 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1138871006453 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871006454 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1138871006455 Cutinase; Region: Cutinase; pfam01083 1138871006456 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 1138871006457 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1138871006458 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1138871006459 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138871006460 active site 1138871006461 phosphorylation site [posttranslational modification] 1138871006462 intermolecular recognition site; other site 1138871006463 dimerization interface [polypeptide binding]; other site 1138871006464 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1138871006465 Cutinase; Region: Cutinase; pfam01083 1138871006466 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871006467 PPE family; Region: PPE; pfam00823 1138871006468 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1138871006469 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1138871006470 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1138871006471 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1138871006472 Walker A/P-loop; other site 1138871006473 ATP binding site [chemical binding]; other site 1138871006474 Q-loop/lid; other site 1138871006475 ABC transporter signature motif; other site 1138871006476 Walker B; other site 1138871006477 D-loop; other site 1138871006478 H-loop/switch region; other site 1138871006479 NMT1-like family; Region: NMT1_2; pfam13379 1138871006480 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1138871006481 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1138871006482 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1138871006483 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 1138871006484 putative dimerization interface [polypeptide binding]; other site 1138871006485 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871006486 PPE family; Region: PPE; pfam00823 1138871006487 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138871006488 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 1138871006489 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 1138871006490 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1138871006491 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1138871006492 SnoaL-like domain; Region: SnoaL_3; pfam13474 1138871006493 short chain dehydrogenase; Provisional; Region: PRK06500 1138871006494 classical (c) SDRs; Region: SDR_c; cd05233 1138871006495 NAD(P) binding site [chemical binding]; other site 1138871006496 active site 1138871006497 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1138871006498 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1138871006499 putative oligomer interface [polypeptide binding]; other site 1138871006500 putative active site [active] 1138871006501 metal binding site [ion binding]; metal-binding site 1138871006502 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1138871006503 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138871006504 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138871006505 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12854 1138871006506 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1138871006507 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1138871006508 hypothetical protein; Provisional; Region: PRK06834 1138871006509 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1138871006510 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 1138871006511 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1138871006512 ATP binding site [chemical binding]; other site 1138871006513 putative Mg++ binding site [ion binding]; other site 1138871006514 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1138871006515 nucleotide binding region [chemical binding]; other site 1138871006516 ATP-binding site [chemical binding]; other site 1138871006517 Helicase associated domain (HA2); Region: HA2; pfam04408 1138871006518 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1138871006519 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1138871006520 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1138871006521 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1138871006522 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138871006523 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138871006524 substrate binding site [chemical binding]; other site 1138871006525 oxyanion hole (OAH) forming residues; other site 1138871006526 trimer interface [polypeptide binding]; other site 1138871006527 Cutinase; Region: Cutinase; pfam01083 1138871006528 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 1138871006529 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1138871006530 catalytic Zn binding site [ion binding]; other site 1138871006531 NAD(P) binding site [chemical binding]; other site 1138871006532 structural Zn binding site [ion binding]; other site 1138871006533 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1138871006534 hydrophobic ligand binding site; other site 1138871006535 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1138871006536 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1138871006537 NAD binding site [chemical binding]; other site 1138871006538 catalytic Zn binding site [ion binding]; other site 1138871006539 structural Zn binding site [ion binding]; other site 1138871006540 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1138871006541 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1138871006542 MOSC domain; Region: MOSC; pfam03473 1138871006543 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871006544 PPE family; Region: PPE; pfam00823 1138871006545 Short C-terminal domain; Region: SHOCT; pfam09851 1138871006546 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1138871006547 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1138871006548 homodimer interface [polypeptide binding]; other site 1138871006549 active site 1138871006550 TDP-binding site; other site 1138871006551 acceptor substrate-binding pocket; other site 1138871006552 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1138871006553 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871006554 S-adenosylmethionine binding site [chemical binding]; other site 1138871006555 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1138871006556 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138871006557 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1138871006558 iron-sulfur cluster [ion binding]; other site 1138871006559 [2Fe-2S] cluster binding site [ion binding]; other site 1138871006560 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like; cl17506 1138871006561 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1138871006562 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1138871006563 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1138871006564 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1138871006565 metal binding site 2 [ion binding]; metal-binding site 1138871006566 putative DNA binding helix; other site 1138871006567 metal binding site 1 [ion binding]; metal-binding site 1138871006568 dimer interface [polypeptide binding]; other site 1138871006569 structural Zn2+ binding site [ion binding]; other site 1138871006570 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1138871006571 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 1138871006572 dimer interface [polypeptide binding]; other site 1138871006573 active site 1138871006574 heme binding site [chemical binding]; other site 1138871006575 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1138871006576 Domain of unknown function (DUF1906); Region: DUF1906; pfam08924 1138871006577 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1138871006578 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1138871006579 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871006580 S-adenosylmethionine binding site [chemical binding]; other site 1138871006581 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1138871006582 Protein of unknown function, DUF608; Region: DUF608; pfam04685 1138871006583 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1138871006584 Cutinase; Region: Cutinase; pfam01083 1138871006585 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871006586 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871006587 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1138871006588 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1138871006589 PE family; Region: PE; pfam00934 1138871006590 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1138871006591 active site 1138871006592 catalytic residues [active] 1138871006593 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138871006594 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1138871006595 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138871006596 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1138871006597 NAD(P) binding site [chemical binding]; other site 1138871006598 catalytic residues [active] 1138871006599 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1138871006600 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138871006601 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1138871006602 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1138871006603 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1138871006604 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1138871006605 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1138871006606 putative acyl-acceptor binding pocket; other site 1138871006607 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1138871006608 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871006609 S-adenosylmethionine binding site [chemical binding]; other site 1138871006610 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871006611 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 1138871006612 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1138871006613 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871006614 NAD(P) binding site [chemical binding]; other site 1138871006615 active site 1138871006616 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871006617 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871006618 active site 1138871006619 YacP-like NYN domain; Region: NYN_YacP; cl01491 1138871006620 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 1138871006621 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1138871006622 FMN binding site [chemical binding]; other site 1138871006623 substrate binding site [chemical binding]; other site 1138871006624 putative catalytic residue [active] 1138871006625 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1138871006626 dimer interface [polypeptide binding]; other site 1138871006627 catalytic triad [active] 1138871006628 peroxidatic and resolving cysteines [active] 1138871006629 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1138871006630 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1138871006631 conserved cys residue [active] 1138871006632 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1138871006633 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1138871006634 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1138871006635 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1138871006636 conserved cys residue [active] 1138871006637 Predicted transcriptional regulators [Transcription]; Region: COG1733 1138871006638 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1138871006639 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1138871006640 SnoaL-like domain; Region: SnoaL_2; pfam12680 1138871006641 short chain dehydrogenase; Provisional; Region: PRK05867 1138871006642 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871006643 NAD(P) binding site [chemical binding]; other site 1138871006644 active site 1138871006645 Beta-lactamase; Region: Beta-lactamase; pfam00144 1138871006646 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1138871006647 putative fatty-acid--CoA ligase; Provisional; Region: PRK12476 1138871006648 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1138871006649 acyl-activating enzyme (AAE) consensus motif; other site 1138871006650 active site 1138871006651 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1138871006652 putative hydrophobic ligand binding site [chemical binding]; other site 1138871006653 protein interface [polypeptide binding]; other site 1138871006654 gate; other site 1138871006655 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1138871006656 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1138871006657 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1138871006658 tetramer interface [polypeptide binding]; other site 1138871006659 active site 1138871006660 Mg2+/Mn2+ binding site [ion binding]; other site 1138871006661 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 1138871006662 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1138871006663 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1138871006664 dimerization interface [polypeptide binding]; other site 1138871006665 putative DNA binding site [nucleotide binding]; other site 1138871006666 putative Zn2+ binding site [ion binding]; other site 1138871006667 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1138871006668 putative hydrophobic ligand binding site [chemical binding]; other site 1138871006669 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1138871006670 putative hydrophobic ligand binding site [chemical binding]; other site 1138871006671 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1138871006672 substrate binding site [chemical binding]; other site 1138871006673 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1138871006674 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138871006675 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1138871006676 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871006677 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1138871006678 Nitronate monooxygenase; Region: NMO; pfam03060 1138871006679 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1138871006680 FMN binding site [chemical binding]; other site 1138871006681 substrate binding site [chemical binding]; other site 1138871006682 putative catalytic residue [active] 1138871006683 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1138871006684 FMN binding site [chemical binding]; other site 1138871006685 dimer interface [polypeptide binding]; other site 1138871006686 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1138871006687 hydrophobic ligand binding site; other site 1138871006688 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1138871006689 Predicted membrane protein [Function unknown]; Region: COG1950 1138871006690 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138871006691 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138871006692 active site 1138871006693 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138871006694 putative sialic acid transporter; Region: 2A0112; TIGR00891 1138871006695 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138871006696 putative substrate translocation pore; other site 1138871006697 competence damage-inducible protein A; Provisional; Region: PRK00549 1138871006698 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1138871006699 putative MPT binding site; other site 1138871006700 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 1138871006701 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330 1138871006702 putative ADP-ribose binding site [chemical binding]; other site 1138871006703 Domain of unknown function DUF77; Region: DUF77; pfam01910 1138871006704 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1138871006705 putative active site [active] 1138871006706 dimerization interface [polypeptide binding]; other site 1138871006707 putative tRNAtyr binding site [nucleotide binding]; other site 1138871006708 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138871006709 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138871006710 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1138871006711 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1138871006712 NAD(P) binding site [chemical binding]; other site 1138871006713 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138871006714 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138871006715 Nitronate monooxygenase; Region: NMO; pfam03060 1138871006716 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1138871006717 FMN binding site [chemical binding]; other site 1138871006718 substrate binding site [chemical binding]; other site 1138871006719 putative catalytic residue [active] 1138871006720 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871006721 Cytochrome P450; Region: p450; cl12078 1138871006722 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1138871006723 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296 1138871006724 putative NAD(P) binding site [chemical binding]; other site 1138871006725 putative substrate binding site [chemical binding]; other site 1138871006726 catalytic Zn binding site [ion binding]; other site 1138871006727 structural Zn binding site [ion binding]; other site 1138871006728 YceI-like domain; Region: YceI; smart00867 1138871006729 Putative esterase; Region: Esterase; pfam00756 1138871006730 chorismate mutase; Provisional; Region: PRK09269 1138871006731 Chorismate mutase type II; Region: CM_2; cl00693 1138871006732 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1138871006733 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1138871006734 hydrophobic ligand binding site; other site 1138871006735 short chain dehydrogenase; Provisional; Region: PRK08267 1138871006736 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871006737 NAD(P) binding site [chemical binding]; other site 1138871006738 active site 1138871006739 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1138871006740 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871006741 Cytochrome P450; Region: p450; cl12078 1138871006742 SnoaL-like domain; Region: SnoaL_2; pfam12680 1138871006743 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1138871006744 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1138871006745 active site 1138871006746 ATP binding site [chemical binding]; other site 1138871006747 substrate binding site [chemical binding]; other site 1138871006748 activation loop (A-loop); other site 1138871006749 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138871006750 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1138871006751 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1138871006752 probable F420-dependent oxidoreductase, MSMEG_3544 family; Region: F420_MSMEG_3544; TIGR03854 1138871006753 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138871006754 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1138871006755 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1138871006756 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138871006757 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1138871006758 putative substrate translocation pore; other site 1138871006759 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138871006760 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1138871006761 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1138871006762 heme binding site [chemical binding]; other site 1138871006763 ferroxidase pore; other site 1138871006764 ferroxidase diiron center [ion binding]; other site 1138871006765 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 1138871006766 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138871006767 substrate binding site [chemical binding]; other site 1138871006768 oxyanion hole (OAH) forming residues; other site 1138871006769 trimer interface [polypeptide binding]; other site 1138871006770 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1138871006771 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1138871006772 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1138871006773 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1138871006774 dimerization interface [polypeptide binding]; other site 1138871006775 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1138871006776 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1138871006777 dimer interface [polypeptide binding]; other site 1138871006778 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1138871006779 catalytic triad [active] 1138871006780 peroxidatic and resolving cysteines [active] 1138871006781 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 1138871006782 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1138871006783 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 1138871006784 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1138871006785 active site 1138871006786 catalytic site [active] 1138871006787 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 1138871006788 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 1138871006789 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 1138871006790 active site 1138871006791 substrate binding site [chemical binding]; other site 1138871006792 FMN binding site [chemical binding]; other site 1138871006793 putative catalytic residues [active] 1138871006794 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1138871006795 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138871006796 Walker A motif; other site 1138871006797 ATP binding site [chemical binding]; other site 1138871006798 Walker B motif; other site 1138871006799 arginine finger; other site 1138871006800 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1138871006801 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1138871006802 TfoX N-terminal domain; Region: TfoX_N; cl17592 1138871006803 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1138871006804 minor groove reading motif; other site 1138871006805 helix-hairpin-helix signature motif; other site 1138871006806 Protein of unknown function DUF72; Region: DUF72; pfam01904 1138871006807 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1138871006808 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138871006809 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138871006810 hypothetical protein; Provisional; Region: PRK12320 1138871006811 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871006812 NAD(P) binding site [chemical binding]; other site 1138871006813 active site 1138871006814 acetyl-CoA acetyltransferase; Validated; Region: PRK08257 1138871006815 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138871006816 active site 1138871006817 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138871006818 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138871006819 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138871006820 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138871006821 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1138871006822 short chain dehydrogenase; Provisional; Region: PRK07825 1138871006823 classical (c) SDRs; Region: SDR_c; cd05233 1138871006824 NAD(P) binding site [chemical binding]; other site 1138871006825 active site 1138871006826 putative phosphoketolase; Provisional; Region: PRK05261 1138871006827 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 1138871006828 TPP-binding site; other site 1138871006829 XFP C-terminal domain; Region: XFP_C; pfam09363 1138871006830 CAAX protease self-immunity; Region: Abi; pfam02517 1138871006831 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1138871006832 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 1138871006833 NAD(P) binding site [chemical binding]; other site 1138871006834 Fibronectin-attachment protein (FAP); Region: FAP; pfam07174 1138871006835 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 1138871006836 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138871006837 Walker A/P-loop; other site 1138871006838 ATP binding site [chemical binding]; other site 1138871006839 Q-loop/lid; other site 1138871006840 ABC transporter signature motif; other site 1138871006841 Walker B; other site 1138871006842 D-loop; other site 1138871006843 H-loop/switch region; other site 1138871006844 TOBE domain; Region: TOBE; cl01440 1138871006845 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1138871006846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138871006847 putative PBP binding loops; other site 1138871006848 ABC-ATPase subunit interface; other site 1138871006849 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1138871006850 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1138871006851 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1138871006852 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1138871006853 classical (c) SDRs; Region: SDR_c; cd05233 1138871006854 NAD(P) binding site [chemical binding]; other site 1138871006855 active site 1138871006856 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1138871006857 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138871006858 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1138871006859 CoenzymeA binding site [chemical binding]; other site 1138871006860 subunit interaction site [polypeptide binding]; other site 1138871006861 PHB binding site; other site 1138871006862 Predicted transcriptional regulator [Transcription]; Region: COG3682 1138871006863 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1138871006864 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1138871006865 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1138871006866 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1138871006867 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 1138871006868 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1138871006869 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1138871006870 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1138871006871 active site 1138871006872 acyl carrier protein; Validated; Region: PRK05883 1138871006873 long-chain-fatty-acid--[acyl-carrier-protein] ligase; Validated; Region: PRK05851 1138871006874 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871006875 acyl-activating enzyme (AAE) consensus motif; other site 1138871006876 AMP binding site [chemical binding]; other site 1138871006877 active site 1138871006878 CoA binding site [chemical binding]; other site 1138871006879 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871006880 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138871006881 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1138871006882 active site 1138871006883 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1138871006884 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1138871006885 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1138871006886 Domain of unknown function DUF21; Region: DUF21; pfam01595 1138871006887 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1138871006888 Transporter associated domain; Region: CorC_HlyC; smart01091 1138871006889 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1138871006890 Domain of unknown function DUF21; Region: DUF21; pfam01595 1138871006891 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1138871006892 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 1138871006893 active site 1138871006894 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1138871006895 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1138871006896 metal ion-dependent adhesion site (MIDAS); other site 1138871006897 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1138871006898 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1138871006899 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871006900 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871006901 glycine dehydrogenase; Provisional; Region: PRK05367 1138871006902 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1138871006903 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138871006904 tetramer interface [polypeptide binding]; other site 1138871006905 catalytic residue [active] 1138871006906 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1138871006907 tetramer interface [polypeptide binding]; other site 1138871006908 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138871006909 catalytic residue [active] 1138871006910 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1138871006911 DNA binding residues [nucleotide binding] 1138871006912 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1138871006913 putative dimer interface [polypeptide binding]; other site 1138871006914 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1138871006915 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1138871006916 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1138871006917 DNA binding residues [nucleotide binding] 1138871006918 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1138871006919 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138871006920 phosphopeptide binding site; other site 1138871006921 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1138871006922 lipoyl attachment site [posttranslational modification]; other site 1138871006923 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1138871006924 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 1138871006925 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 1138871006926 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1138871006927 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1138871006928 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 1138871006929 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1138871006930 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1138871006931 nucleotide binding region [chemical binding]; other site 1138871006932 ATP-binding site [chemical binding]; other site 1138871006933 hypothetical protein; Provisional; Region: PRK05858 1138871006934 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1138871006935 PYR/PP interface [polypeptide binding]; other site 1138871006936 dimer interface [polypeptide binding]; other site 1138871006937 TPP binding site [chemical binding]; other site 1138871006938 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1138871006939 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1138871006940 TPP-binding site; other site 1138871006941 dimer interface [polypeptide binding]; other site 1138871006942 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1138871006943 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1138871006944 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1138871006945 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1138871006946 active site 1138871006947 metal binding site [ion binding]; metal-binding site 1138871006948 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871006949 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871006950 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1138871006951 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1138871006952 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1138871006953 MgtC family; Region: MgtC; pfam02308 1138871006954 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138871006955 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871006956 PPE family; Region: PPE; pfam00823 1138871006957 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138871006958 PPE family; Region: PPE; pfam00823 1138871006959 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138871006960 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138871006961 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138871006962 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871006963 PPE family; Region: PPE; pfam00823 1138871006964 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138871006965 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871006966 PPE family; Region: PPE; pfam00823 1138871006967 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871006968 PPE family; Region: PPE; pfam00823 1138871006969 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1138871006970 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138871006971 Walker A motif; other site 1138871006972 ATP binding site [chemical binding]; other site 1138871006973 Walker B motif; other site 1138871006974 arginine finger; other site 1138871006975 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1138871006976 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1138871006977 catalytic residues [active] 1138871006978 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1138871006979 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 1138871006980 active site 1138871006981 catalytic residues [active] 1138871006982 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1138871006983 EspG family; Region: ESX-1_EspG; pfam14011 1138871006984 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1138871006985 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1138871006986 PE family; Region: PE; pfam00934 1138871006987 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871006988 PPE family; Region: PPE; pfam00823 1138871006989 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871006990 PPE family; Region: PPE; pfam00823 1138871006991 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138871006992 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871006993 PPE family; Region: PPE; pfam00823 1138871006994 PE family; Region: PE; pfam00934 1138871006995 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871006996 PPE family; Region: PPE; pfam00823 1138871006997 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138871006998 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1138871006999 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871007000 Cytochrome P450; Region: p450; cl12078 1138871007001 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1138871007002 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138871007003 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1138871007004 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138871007005 Protein of unknown function (DUF690); Region: DUF690; cl04939 1138871007006 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1138871007007 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1138871007008 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138871007009 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1138871007010 SnoaL-like domain; Region: SnoaL_4; pfam13577 1138871007011 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 1138871007012 bacterial subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. This domain is found in a variety of oxidoreductases. Common features of all known members of this family, like sulfite oxidase and nitrite reductase, are that they...; Region: bact_SO_family_Moco; cd02108 1138871007013 Moco binding site; other site 1138871007014 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1138871007015 metal coordination site [ion binding]; other site 1138871007016 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 1138871007017 hydrophobic ligand binding site; other site 1138871007018 Domain of unknown function (DUF4407); Region: DUF4407; pfam14362 1138871007019 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138871007020 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138871007021 Helix-turn-helix domain; Region: HTH_18; pfam12833 1138871007022 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1138871007023 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1138871007024 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138871007025 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138871007026 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1138871007027 classical (c) SDRs; Region: SDR_c; cd05233 1138871007028 NAD(P) binding site [chemical binding]; other site 1138871007029 active site 1138871007030 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1138871007031 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1138871007032 tetramer interface [polypeptide binding]; other site 1138871007033 TPP-binding site [chemical binding]; other site 1138871007034 heterodimer interface [polypeptide binding]; other site 1138871007035 phosphorylation loop region [posttranslational modification] 1138871007036 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1138871007037 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1138871007038 alpha subunit interface [polypeptide binding]; other site 1138871007039 TPP binding site [chemical binding]; other site 1138871007040 heterodimer interface [polypeptide binding]; other site 1138871007041 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1138871007042 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1138871007043 E3 interaction surface; other site 1138871007044 lipoyl attachment site [posttranslational modification]; other site 1138871007045 enoyl-CoA hydratase; Provisional; Region: PRK06144 1138871007046 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138871007047 substrate binding site [chemical binding]; other site 1138871007048 oxyanion hole (OAH) forming residues; other site 1138871007049 trimer interface [polypeptide binding]; other site 1138871007050 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 1138871007051 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871007052 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1138871007053 acyl-activating enzyme (AAE) consensus motif; other site 1138871007054 putative AMP binding site [chemical binding]; other site 1138871007055 putative active site [active] 1138871007056 acyl-activating enzyme (AAE) consensus motif; other site 1138871007057 putative CoA binding site [chemical binding]; other site 1138871007058 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1138871007059 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1138871007060 [2Fe-2S] cluster binding site [ion binding]; other site 1138871007061 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1138871007062 hydrophobic ligand binding site; other site 1138871007063 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 1138871007064 enoyl-CoA hydratase; Provisional; Region: PRK06190 1138871007065 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138871007066 substrate binding site [chemical binding]; other site 1138871007067 oxyanion hole (OAH) forming residues; other site 1138871007068 trimer interface [polypeptide binding]; other site 1138871007069 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 1138871007070 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 1138871007071 thiocyanate hydrolase, gamma subunit; Region: thiocyan_alph; TIGR03887 1138871007072 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 1138871007073 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1138871007074 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1138871007075 ATP binding site [chemical binding]; other site 1138871007076 Mg++ binding site [ion binding]; other site 1138871007077 motif III; other site 1138871007078 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1138871007079 nucleotide binding region [chemical binding]; other site 1138871007080 ATP-binding site [chemical binding]; other site 1138871007081 Methyltransferase domain; Region: Methyltransf_18; pfam12847 1138871007082 S-adenosylmethionine binding site [chemical binding]; other site 1138871007083 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871007084 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871007085 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1138871007086 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138871007087 active site 1138871007088 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138871007089 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871007090 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871007091 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138871007092 classical (c) SDRs; Region: SDR_c; cd05233 1138871007093 NAD(P) binding site [chemical binding]; other site 1138871007094 active site 1138871007095 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 1138871007096 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138871007097 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1138871007098 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138871007099 DNA binding residues [nucleotide binding] 1138871007100 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1138871007101 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871007102 Cytochrome P450; Region: p450; cl12078 1138871007103 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871007104 short chain dehydrogenase; Provisional; Region: PRK05854 1138871007105 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1138871007106 putative NAD(P) binding site [chemical binding]; other site 1138871007107 active site 1138871007108 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138871007109 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1138871007110 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1138871007111 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1138871007112 active site 1138871007113 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1138871007114 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1138871007115 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1138871007116 active site 1138871007117 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138871007118 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138871007119 active site 1138871007120 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871007121 NAD(P) binding site [chemical binding]; other site 1138871007122 active site 1138871007123 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138871007124 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138871007125 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138871007126 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138871007127 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138871007128 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138871007129 enoyl-CoA hydratase; Provisional; Region: PRK12478 1138871007130 substrate binding site [chemical binding]; other site 1138871007131 oxyanion hole (OAH) forming residues; other site 1138871007132 trimer interface [polypeptide binding]; other site 1138871007133 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1138871007134 classical (c) SDRs; Region: SDR_c; cd05233 1138871007135 NAD(P) binding site [chemical binding]; other site 1138871007136 active site 1138871007137 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871007138 Cytochrome P450; Region: p450; cl12078 1138871007139 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871007140 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871007141 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1138871007142 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1138871007143 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1138871007144 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871007145 S-adenosylmethionine binding site [chemical binding]; other site 1138871007146 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1138871007147 Sulfatase; Region: Sulfatase; pfam00884 1138871007148 Nitronate monooxygenase; Region: NMO; pfam03060 1138871007149 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1138871007150 FMN binding site [chemical binding]; other site 1138871007151 substrate binding site [chemical binding]; other site 1138871007152 putative catalytic residue [active] 1138871007153 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138871007154 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1138871007155 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138871007156 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 1138871007157 intersubunit interface [polypeptide binding]; other site 1138871007158 active site 1138871007159 Zn2+ binding site [ion binding]; other site 1138871007160 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1138871007161 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871007162 acyl-activating enzyme (AAE) consensus motif; other site 1138871007163 AMP binding site [chemical binding]; other site 1138871007164 active site 1138871007165 CoA binding site [chemical binding]; other site 1138871007166 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1138871007167 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 1138871007168 Moco binding site; other site 1138871007169 metal coordination site [ion binding]; other site 1138871007170 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1138871007171 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1138871007172 putative di-iron ligands [ion binding]; other site 1138871007173 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1138871007174 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1138871007175 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1138871007176 FAD binding pocket [chemical binding]; other site 1138871007177 FAD binding motif [chemical binding]; other site 1138871007178 phosphate binding motif [ion binding]; other site 1138871007179 beta-alpha-beta structure motif; other site 1138871007180 NAD binding pocket [chemical binding]; other site 1138871007181 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1138871007182 catalytic loop [active] 1138871007183 iron binding site [ion binding]; other site 1138871007184 acyl-CoA synthetase; Provisional; Region: PRK13388 1138871007185 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871007186 acyl-activating enzyme (AAE) consensus motif; other site 1138871007187 AMP binding site [chemical binding]; other site 1138871007188 active site 1138871007189 CoA binding site [chemical binding]; other site 1138871007190 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138871007191 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138871007192 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1138871007193 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138871007194 thiolase; Provisional; Region: PRK06158 1138871007195 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138871007196 active site 1138871007197 SAV4209 is a Streptomyces avermitilis protein with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. The alpha- and...; Region: SAV4209; cd03455 1138871007198 putative active site [active] 1138871007199 putative catalytic site [active] 1138871007200 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1138871007201 active site 1138871007202 catalytic site [active] 1138871007203 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871007204 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871007205 active site 1138871007206 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871007207 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871007208 active site 1138871007209 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1138871007210 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138871007211 phosphopeptide binding site; other site 1138871007212 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138871007213 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1138871007214 phosphopeptide binding site; other site 1138871007215 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1138871007216 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1138871007217 Walker A/P-loop; other site 1138871007218 ATP binding site [chemical binding]; other site 1138871007219 Q-loop/lid; other site 1138871007220 ABC transporter signature motif; other site 1138871007221 Walker B; other site 1138871007222 D-loop; other site 1138871007223 H-loop/switch region; other site 1138871007224 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1138871007225 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1138871007226 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138871007227 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138871007228 short chain dehydrogenase; Provisional; Region: PRK06057 1138871007229 classical (c) SDRs; Region: SDR_c; cd05233 1138871007230 NAD(P) binding site [chemical binding]; other site 1138871007231 active site 1138871007232 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1138871007233 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1138871007234 molybdopterin cofactor binding site; other site 1138871007235 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 1138871007236 putative molybdopterin cofactor binding site; other site 1138871007237 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1138871007238 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138871007239 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1138871007240 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138871007241 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1138871007242 SnoaL-like domain; Region: SnoaL_4; pfam13577 1138871007243 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871007244 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1138871007245 NAD(P) binding site [chemical binding]; other site 1138871007246 active site 1138871007247 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1138871007248 classical (c) SDRs; Region: SDR_c; cd05233 1138871007249 NAD(P) binding site [chemical binding]; other site 1138871007250 active site 1138871007251 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1138871007252 classical (c) SDRs; Region: SDR_c; cd05233 1138871007253 NAD(P) binding site [chemical binding]; other site 1138871007254 active site 1138871007255 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138871007256 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138871007257 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1138871007258 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1138871007259 catalytic loop [active] 1138871007260 iron binding site [ion binding]; other site 1138871007261 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871007262 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871007263 active site 1138871007264 2,3-dihydroxybiphenyl 1,2-dioxygenase; Region: 23dbph12diox; TIGR03213 1138871007265 N-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_N_like; cd07252 1138871007266 C-terminal domain of 2,3-dihydroxybiphenyl 1,2-dioxygenase (BphC, EC 1.13.11.39) 1 from Rhodococcus globerulus P6 (BphC1-RGP6) and similar proteins; Region: BphC1-RGP6_C_like; cd07237 1138871007267 active site 1138871007268 Fe binding site [ion binding]; other site 1138871007269 hypothetical protein; Validated; Region: PRK07121 1138871007270 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1138871007271 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1138871007272 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1138871007273 Bacterial transcriptional regulator; Region: IclR; pfam01614 1138871007274 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1138871007275 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138871007276 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138871007277 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 1138871007278 active site 1138871007279 FMN binding site [chemical binding]; other site 1138871007280 substrate binding site [chemical binding]; other site 1138871007281 putative catalytic residue [active] 1138871007282 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 1138871007283 human dehydrogenase/reductase (SDR family) member 1 (DHRS1) and human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: DHRS1_HSDL2-like_SDR_c; cd05338 1138871007284 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1138871007285 NAD(P) binding site [chemical binding]; other site 1138871007286 homodimer interface [polypeptide binding]; other site 1138871007287 active site 1138871007288 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138871007289 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138871007290 acyl-CoA synthetase; Validated; Region: PRK08316 1138871007291 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871007292 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1138871007293 acyl-activating enzyme (AAE) consensus motif; other site 1138871007294 putative AMP binding site [chemical binding]; other site 1138871007295 putative active site [active] 1138871007296 putative CoA binding site [chemical binding]; other site 1138871007297 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 1138871007298 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1138871007299 catalytic Zn binding site [ion binding]; other site 1138871007300 structural Zn binding site [ion binding]; other site 1138871007301 tetramer interface [polypeptide binding]; other site 1138871007302 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 1138871007303 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138871007304 NAD binding site [chemical binding]; other site 1138871007305 catalytic residues [active] 1138871007306 enoyl-CoA hydratase; Provisional; Region: PRK09245 1138871007307 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138871007308 substrate binding site [chemical binding]; other site 1138871007309 oxyanion hole (OAH) forming residues; other site 1138871007310 trimer interface [polypeptide binding]; other site 1138871007311 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871007312 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871007313 active site 1138871007314 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871007315 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138871007316 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871007317 SnoaL-like domain; Region: SnoaL_4; pfam13577 1138871007318 hypothetical protein; Provisional; Region: PRK06194 1138871007319 classical (c) SDRs; Region: SDR_c; cd05233 1138871007320 NAD(P) binding site [chemical binding]; other site 1138871007321 active site 1138871007322 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1138871007323 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138871007324 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138871007325 classical (c) SDRs; Region: SDR_c; cd05233 1138871007326 NAD(P) binding site [chemical binding]; other site 1138871007327 active site 1138871007328 SnoaL-like domain; Region: SnoaL_4; pfam13577 1138871007329 short chain dehydrogenase; Provisional; Region: PRK08303 1138871007330 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871007331 NAD(P) binding site [chemical binding]; other site 1138871007332 active site 1138871007333 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1138871007334 The alignment model represents the N-terminal rieske iron-sulfur domain of KshA, the oxygenase component of 3-ketosteroid 9-alpha-hydroxylase (KSH). The terminal oxygenase component of KSH is a key enzyme in the microbial steroid degradation pathway; Region: Rieske_RO_Alpha_KSH; cd03531 1138871007335 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12845 1138871007336 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1138871007337 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138871007338 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138871007339 active site 1138871007340 Predicted transcriptional regulators [Transcription]; Region: COG1695 1138871007341 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1138871007342 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1138871007343 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138871007344 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1138871007345 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1138871007346 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1138871007347 Probable transposase; Region: OrfB_IS605; pfam01385 1138871007348 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 1138871007349 hypothetical protein; Provisional; Region: PRK14059 1138871007350 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1138871007351 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1138871007352 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1138871007353 active site 1138871007354 ATP binding site [chemical binding]; other site 1138871007355 substrate binding site [chemical binding]; other site 1138871007356 activation loop (A-loop); other site 1138871007357 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1138871007358 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138871007359 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138871007360 GNAT-family acetyltransferase TIGR03103; Region: trio_acet_GNAT 1138871007361 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1138871007362 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1138871007363 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1138871007364 asparagine synthase family amidotransferase; Region: trio_amidotrans; TIGR03104 1138871007365 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1138871007366 dimer interface [polypeptide binding]; other site 1138871007367 active site 1138871007368 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1138871007369 Ligand Binding Site [chemical binding]; other site 1138871007370 Molecular Tunnel; other site 1138871007371 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1138871007372 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1138871007373 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138871007374 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138871007375 acyl-activating enzyme (AAE) consensus motif; other site 1138871007376 AMP binding site [chemical binding]; other site 1138871007377 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138871007378 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1138871007379 nudix motif; other site 1138871007380 Condensation domain; Region: Condensation; pfam00668 1138871007381 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138871007382 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1138871007383 acyl-activating enzyme (AAE) consensus motif; other site 1138871007384 AMP binding site [chemical binding]; other site 1138871007385 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138871007386 Condensation domain; Region: Condensation; pfam00668 1138871007387 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1138871007388 Condensation domain; Region: Condensation; pfam00668 1138871007389 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138871007390 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138871007391 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1138871007392 acyl-activating enzyme (AAE) consensus motif; other site 1138871007393 AMP binding site [chemical binding]; other site 1138871007394 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871007395 S-adenosylmethionine binding site [chemical binding]; other site 1138871007396 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871007397 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138871007398 Condensation domain; Region: Condensation; pfam00668 1138871007399 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138871007400 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138871007401 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138871007402 acyl-activating enzyme (AAE) consensus motif; other site 1138871007403 AMP binding site [chemical binding]; other site 1138871007404 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138871007405 peptide synthase; Provisional; Region: PRK12467 1138871007406 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138871007407 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138871007408 acyl-activating enzyme (AAE) consensus motif; other site 1138871007409 AMP binding site [chemical binding]; other site 1138871007410 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138871007411 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138871007412 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138871007413 acyl-activating enzyme (AAE) consensus motif; other site 1138871007414 AMP binding site [chemical binding]; other site 1138871007415 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138871007416 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1138871007417 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138871007418 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138871007419 acyl-activating enzyme (AAE) consensus motif; other site 1138871007420 AMP binding site [chemical binding]; other site 1138871007421 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138871007422 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138871007423 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138871007424 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138871007425 acyl-activating enzyme (AAE) consensus motif; other site 1138871007426 AMP binding site [chemical binding]; other site 1138871007427 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138871007428 MbtH-like protein; Region: MbtH; pfam03621 1138871007429 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1138871007430 ANTAR domain; Region: ANTAR; pfam03861 1138871007431 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 1138871007432 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 1138871007433 NAD(P) binding site [chemical binding]; other site 1138871007434 catalytic residues [active] 1138871007435 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 1138871007436 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 1138871007437 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1138871007438 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138871007439 Peptidase family M48; Region: Peptidase_M48; cl12018 1138871007440 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1138871007441 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1138871007442 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1138871007443 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1138871007444 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1138871007445 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1138871007446 DNA binding residues [nucleotide binding] 1138871007447 dimer interface [polypeptide binding]; other site 1138871007448 metal binding site [ion binding]; metal-binding site 1138871007449 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1138871007450 Putative zinc-finger; Region: zf-HC2; pfam13490 1138871007451 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 1138871007452 Homeodomain-like domain; Region: HTH_23; pfam13384 1138871007453 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1138871007454 Integrase core domain; Region: rve; pfam00665 1138871007455 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1138871007456 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138871007457 Walker A motif; other site 1138871007458 ATP binding site [chemical binding]; other site 1138871007459 Walker B motif; other site 1138871007460 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1138871007461 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1138871007462 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1138871007463 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1138871007464 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 1138871007465 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1138871007466 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1138871007467 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1138871007468 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138871007469 active site 1138871007470 motif I; other site 1138871007471 motif II; other site 1138871007472 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1138871007473 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1138871007474 dimerization interface [polypeptide binding]; other site 1138871007475 putative DNA binding site [nucleotide binding]; other site 1138871007476 putative Zn2+ binding site [ion binding]; other site 1138871007477 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1138871007478 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1138871007479 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1138871007480 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1138871007481 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1138871007482 MgtE intracellular N domain; Region: MgtE_N; smart00924 1138871007483 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1138871007484 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1138871007485 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1138871007486 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138871007487 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1138871007488 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1138871007489 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1138871007490 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1138871007491 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871007492 S-adenosylmethionine binding site [chemical binding]; other site 1138871007493 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1138871007494 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1138871007495 dimer interface [polypeptide binding]; other site 1138871007496 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138871007497 catalytic residue [active] 1138871007498 multidrug resistance protein MdtH; Provisional; Region: PRK11646 1138871007499 PE family; Region: PE; pfam00934 1138871007500 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871007501 PPE family; Region: PPE; pfam00823 1138871007502 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1138871007503 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1138871007504 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 1138871007505 NADH dehydrogenase; Region: NADHdh; cl00469 1138871007506 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 1138871007507 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1138871007508 NADH dehydrogenase subunit 4; Provisional; Region: ND4; MTH00150 1138871007509 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1138871007510 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1138871007511 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1138871007512 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1138871007513 putative FMN binding site [chemical binding]; other site 1138871007514 NADPH bind site [chemical binding]; other site 1138871007515 Condensation domain; Region: Condensation; pfam00668 1138871007516 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138871007517 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138871007518 acyl-activating enzyme (AAE) consensus motif; other site 1138871007519 AMP binding site [chemical binding]; other site 1138871007520 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138871007521 Condensation domain; Region: Condensation; pfam00668 1138871007522 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1138871007523 Condensation domain; Region: Condensation; pfam00668 1138871007524 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138871007525 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138871007526 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1138871007527 acyl-activating enzyme (AAE) consensus motif; other site 1138871007528 AMP binding site [chemical binding]; other site 1138871007529 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138871007530 Condensation domain; Region: Condensation; pfam00668 1138871007531 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138871007532 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138871007533 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138871007534 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1138871007535 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1138871007536 Thioesterase domain; Region: Thioesterase; pfam00975 1138871007537 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138871007538 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1138871007539 active site 1138871007540 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1138871007541 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1138871007542 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 1138871007543 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1138871007544 NADP binding site [chemical binding]; other site 1138871007545 active site 1138871007546 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138871007547 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1138871007548 metal-binding site [ion binding] 1138871007549 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1138871007550 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1138871007551 metal-binding site [ion binding] 1138871007552 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1138871007553 Domain of unknown function (DUF305); Region: DUF305; pfam03713 1138871007554 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871007555 PPE family; Region: PPE; pfam00823 1138871007556 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1138871007557 putative homodimer interface [polypeptide binding]; other site 1138871007558 putative homotetramer interface [polypeptide binding]; other site 1138871007559 putative allosteric switch controlling residues; other site 1138871007560 putative metal binding site [ion binding]; other site 1138871007561 putative homodimer-homodimer interface [polypeptide binding]; other site 1138871007562 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1138871007563 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1138871007564 dimer interface [polypeptide binding]; other site 1138871007565 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138871007566 catalytic residue [active] 1138871007567 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 1138871007568 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1138871007569 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Y4yA; Region: PLPDE_III_Y4yA_like; cd06842 1138871007570 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1138871007571 dimer interface [polypeptide binding]; other site 1138871007572 active site 1138871007573 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1138871007574 catalytic residues [active] 1138871007575 substrate binding site [chemical binding]; other site 1138871007576 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1138871007577 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1138871007578 cation binding site [ion binding]; other site 1138871007579 multidrug resistance protein MdtH; Provisional; Region: PRK11646 1138871007580 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1138871007581 Helix-turn-helix domain; Region: HTH_38; pfam13936 1138871007582 Integrase core domain; Region: rve; pfam00665 1138871007583 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138871007584 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1138871007585 Walker A motif; other site 1138871007586 ATP binding site [chemical binding]; other site 1138871007587 Walker B motif; other site 1138871007588 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 1138871007589 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1138871007590 active site 1138871007591 catalytic residues [active] 1138871007592 DNA binding site [nucleotide binding] 1138871007593 Int/Topo IB signature motif; other site 1138871007594 GTP-binding protein Der; Reviewed; Region: PRK03003 1138871007595 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1138871007596 GTP/Mg2+ binding site [chemical binding]; other site 1138871007597 Switch I region; other site 1138871007598 G2 box; other site 1138871007599 Switch II region; other site 1138871007600 G3 box; other site 1138871007601 G4 box; other site 1138871007602 G5 box; other site 1138871007603 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1138871007604 G1 box; other site 1138871007605 GTP/Mg2+ binding site [chemical binding]; other site 1138871007606 Switch I region; other site 1138871007607 G2 box; other site 1138871007608 G3 box; other site 1138871007609 Switch II region; other site 1138871007610 G4 box; other site 1138871007611 G5 box; other site 1138871007612 cytidylate kinase; Provisional; Region: cmk; PRK00023 1138871007613 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1138871007614 CMP-binding site; other site 1138871007615 The sites determining sugar specificity; other site 1138871007616 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1138871007617 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1138871007618 RNA binding surface [nucleotide binding]; other site 1138871007619 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1138871007620 active site 1138871007621 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1138871007622 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1138871007623 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1138871007624 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1138871007625 P loop; other site 1138871007626 Nucleotide binding site [chemical binding]; other site 1138871007627 DTAP/Switch II; other site 1138871007628 Switch I; other site 1138871007629 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1138871007630 Magnesium ion binding site [ion binding]; other site 1138871007631 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1138871007632 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871007633 S-adenosylmethionine binding site [chemical binding]; other site 1138871007634 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1138871007635 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1138871007636 active site 1138871007637 DNA binding site [nucleotide binding] 1138871007638 Int/Topo IB signature motif; other site 1138871007639 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 1138871007640 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1138871007641 dimer interface [polypeptide binding]; other site 1138871007642 active site 1138871007643 ADP-ribose binding site [chemical binding]; other site 1138871007644 nudix motif; other site 1138871007645 metal binding site [ion binding]; metal-binding site 1138871007646 CTP synthetase; Validated; Region: pyrG; PRK05380 1138871007647 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1138871007648 Catalytic site [active] 1138871007649 active site 1138871007650 UTP binding site [chemical binding]; other site 1138871007651 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1138871007652 active site 1138871007653 putative oxyanion hole; other site 1138871007654 catalytic triad [active] 1138871007655 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 1138871007656 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 1138871007657 Thiamine pyrophosphokinase; Region: TPK; cl08415 1138871007658 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 1138871007659 DNA repair protein RecN; Region: recN; TIGR00634 1138871007660 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138871007661 Walker A/P-loop; other site 1138871007662 ATP binding site [chemical binding]; other site 1138871007663 Q-loop/lid; other site 1138871007664 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1138871007665 ABC transporter signature motif; other site 1138871007666 Walker B; other site 1138871007667 D-loop; other site 1138871007668 H-loop/switch region; other site 1138871007669 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 1138871007670 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1138871007671 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1138871007672 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1138871007673 RNA binding surface [nucleotide binding]; other site 1138871007674 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871007675 S-adenosylmethionine binding site [chemical binding]; other site 1138871007676 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1138871007677 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138871007678 active site 1138871007679 motif I; other site 1138871007680 motif II; other site 1138871007681 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1138871007682 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1138871007683 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138871007684 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1138871007685 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1138871007686 active site 1138871007687 HIGH motif; other site 1138871007688 dimer interface [polypeptide binding]; other site 1138871007689 KMSKS motif; other site 1138871007690 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1138871007691 RNA binding surface [nucleotide binding]; other site 1138871007692 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1138871007693 active site 1138871007694 DNA binding site [nucleotide binding] 1138871007695 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1138871007696 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1138871007697 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1138871007698 Walker A/P-loop; other site 1138871007699 ATP binding site [chemical binding]; other site 1138871007700 Q-loop/lid; other site 1138871007701 ABC transporter signature motif; other site 1138871007702 Walker B; other site 1138871007703 D-loop; other site 1138871007704 H-loop/switch region; other site 1138871007705 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1138871007706 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1138871007707 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871007708 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871007709 Uncharacterized conserved protein [Function unknown]; Region: COG2835 1138871007710 acyl-CoA synthetase; Validated; Region: PRK07868 1138871007711 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 1138871007712 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871007713 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871007714 active site 1138871007715 CoA binding site [chemical binding]; other site 1138871007716 AMP binding site [chemical binding]; other site 1138871007717 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 1138871007718 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1138871007719 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1138871007720 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1138871007721 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1138871007722 short chain dehydrogenase; Provisional; Region: PRK07109 1138871007723 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 1138871007724 putative NAD(P) binding site [chemical binding]; other site 1138871007725 active site 1138871007726 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 3. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_3; cd03328 1138871007727 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1138871007728 putative active site pocket [active] 1138871007729 putative metal binding site [ion binding]; other site 1138871007730 PAS fold; Region: PAS_3; pfam08447 1138871007731 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1138871007732 putative active site [active] 1138871007733 heme pocket [chemical binding]; other site 1138871007734 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1138871007735 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1138871007736 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138871007737 Walker A/P-loop; other site 1138871007738 ATP binding site [chemical binding]; other site 1138871007739 Q-loop/lid; other site 1138871007740 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1138871007741 ABC transporter; Region: ABC_tran_2; pfam12848 1138871007742 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1138871007743 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138871007744 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138871007745 active site 1138871007746 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1138871007747 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1138871007748 malonyl-CoA binding site [chemical binding]; other site 1138871007749 dimer interface [polypeptide binding]; other site 1138871007750 active site 1138871007751 product binding site; other site 1138871007752 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138871007753 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1138871007754 active site 1138871007755 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1138871007756 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1138871007757 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138871007758 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1138871007759 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138871007760 active site 1138871007761 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1138871007762 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1138871007763 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871007764 Enoylreductase; Region: PKS_ER; smart00829 1138871007765 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1138871007766 NAD(P) binding site [chemical binding]; other site 1138871007767 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1138871007768 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1138871007769 putative NADP binding site [chemical binding]; other site 1138871007770 active site 1138871007771 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138871007772 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1138871007773 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1138871007774 active site 1138871007775 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1138871007776 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1138871007777 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871007778 Enoylreductase; Region: PKS_ER; smart00829 1138871007779 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1138871007780 NAD(P) binding site [chemical binding]; other site 1138871007781 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 1138871007782 putative NADP binding site [chemical binding]; other site 1138871007783 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1138871007784 active site 1138871007785 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138871007786 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1138871007787 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1138871007788 malonyl-CoA binding site [chemical binding]; other site 1138871007789 dimer interface [polypeptide binding]; other site 1138871007790 active site 1138871007791 product binding site; other site 1138871007792 argininosuccinate lyase; Provisional; Region: PRK00855 1138871007793 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1138871007794 active sites [active] 1138871007795 tetramer interface [polypeptide binding]; other site 1138871007796 argininosuccinate synthase; Provisional; Region: PRK13820 1138871007797 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1138871007798 ANP binding site [chemical binding]; other site 1138871007799 Substrate Binding Site II [chemical binding]; other site 1138871007800 Substrate Binding Site I [chemical binding]; other site 1138871007801 arginine repressor; Provisional; Region: PRK03341 1138871007802 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1138871007803 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1138871007804 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1138871007805 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1138871007806 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1138871007807 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 1138871007808 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1138871007809 inhibitor-cofactor binding pocket; inhibition site 1138871007810 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138871007811 catalytic residue [active] 1138871007812 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1138871007813 feedback inhibition sensing region; other site 1138871007814 homohexameric interface [polypeptide binding]; other site 1138871007815 nucleotide binding site [chemical binding]; other site 1138871007816 N-acetyl-L-glutamate binding site [chemical binding]; other site 1138871007817 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1138871007818 heterotetramer interface [polypeptide binding]; other site 1138871007819 active site pocket [active] 1138871007820 cleavage site 1138871007821 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1138871007822 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1138871007823 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1138871007824 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1138871007825 putative tRNA-binding site [nucleotide binding]; other site 1138871007826 B3/4 domain; Region: B3_4; pfam03483 1138871007827 tRNA synthetase B5 domain; Region: B5; smart00874 1138871007828 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1138871007829 dimer interface [polypeptide binding]; other site 1138871007830 motif 1; other site 1138871007831 motif 3; other site 1138871007832 motif 2; other site 1138871007833 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1138871007834 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1138871007835 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1138871007836 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1138871007837 dimer interface [polypeptide binding]; other site 1138871007838 motif 1; other site 1138871007839 active site 1138871007840 motif 2; other site 1138871007841 motif 3; other site 1138871007842 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1138871007843 cyclase homology domain; Region: CHD; cd07302 1138871007844 nucleotidyl binding site; other site 1138871007845 metal binding site [ion binding]; metal-binding site 1138871007846 dimer interface [polypeptide binding]; other site 1138871007847 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3662 1138871007848 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1138871007849 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1138871007850 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1138871007851 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1138871007852 23S rRNA binding site [nucleotide binding]; other site 1138871007853 L21 binding site [polypeptide binding]; other site 1138871007854 L13 binding site [polypeptide binding]; other site 1138871007855 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1138871007856 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1138871007857 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1138871007858 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1138871007859 lysyl-tRNA synthetase; Provisional; Region: lysS; PRK02983 1138871007860 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1138871007861 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1138871007862 dimer interface [polypeptide binding]; other site 1138871007863 putative anticodon binding site; other site 1138871007864 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1138871007865 motif 1; other site 1138871007866 dimer interface [polypeptide binding]; other site 1138871007867 active site 1138871007868 motif 2; other site 1138871007869 motif 3; other site 1138871007870 Predicted esterase [General function prediction only]; Region: COG0627 1138871007871 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871007872 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871007873 hypothetical protein; Provisional; Region: PRK07877 1138871007874 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 1138871007875 ATP binding site [chemical binding]; other site 1138871007876 substrate interface [chemical binding]; other site 1138871007877 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1138871007878 dimer interface [polypeptide binding]; other site 1138871007879 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1138871007880 Cytochrome P450; Region: p450; cl12078 1138871007881 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871007882 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1138871007883 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1138871007884 metal binding site [ion binding]; metal-binding site 1138871007885 active site 1138871007886 I-site; other site 1138871007887 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1138871007888 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871007889 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1138871007890 S-adenosylmethionine binding site [chemical binding]; other site 1138871007891 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1138871007892 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1138871007893 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1138871007894 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1138871007895 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1138871007896 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1138871007897 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1138871007898 Ligand Binding Site [chemical binding]; other site 1138871007899 Predicted membrane protein [Function unknown]; Region: COG5305 1138871007900 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138871007901 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1138871007902 putative substrate translocation pore; other site 1138871007903 excinuclease ABC subunit B; Provisional; Region: PRK05298 1138871007904 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1138871007905 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1138871007906 nucleotide binding region [chemical binding]; other site 1138871007907 ATP-binding site [chemical binding]; other site 1138871007908 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1138871007909 UvrB/uvrC motif; Region: UVR; pfam02151 1138871007910 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1138871007911 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1138871007912 active site 1138871007913 ATP binding site [chemical binding]; other site 1138871007914 substrate binding site [chemical binding]; other site 1138871007915 activation loop (A-loop); other site 1138871007916 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138871007917 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1138871007918 phosphopeptide binding site; other site 1138871007919 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1138871007920 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138871007921 phosphopeptide binding site; other site 1138871007922 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1138871007923 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1138871007924 Walker A/P-loop; other site 1138871007925 ATP binding site [chemical binding]; other site 1138871007926 Q-loop/lid; other site 1138871007927 ABC transporter signature motif; other site 1138871007928 Walker B; other site 1138871007929 D-loop; other site 1138871007930 H-loop/switch region; other site 1138871007931 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1138871007932 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1138871007933 Protein of unknown function (DUF402); Region: DUF402; cl00979 1138871007934 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1138871007935 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1138871007936 ligand binding site [chemical binding]; other site 1138871007937 flexible hinge region; other site 1138871007938 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1138871007939 CheB methylesterase; Region: CheB_methylest; pfam01339 1138871007940 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1138871007941 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 1138871007942 active site 1138871007943 DNA binding site [nucleotide binding] 1138871007944 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1138871007945 DNA binding site [nucleotide binding] 1138871007946 LigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: LigD_Pol_like; cd04861 1138871007947 nucleotide binding site [chemical binding]; other site 1138871007948 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1138871007949 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cd08773 1138871007950 DNA binding site [nucleotide binding] 1138871007951 catalytic residue [active] 1138871007952 H2TH interface [polypeptide binding]; other site 1138871007953 putative catalytic residues [active] 1138871007954 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1138871007955 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1138871007956 dephospho-CoA kinase/protein folding accessory domain-containing protein; Provisional; Region: coaE; PRK03333 1138871007957 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1138871007958 CoA-binding site [chemical binding]; other site 1138871007959 ATP-binding [chemical binding]; other site 1138871007960 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1138871007961 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1138871007962 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1138871007963 RNA binding site [nucleotide binding]; other site 1138871007964 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1138871007965 RNA binding site [nucleotide binding]; other site 1138871007966 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1138871007967 RNA binding site [nucleotide binding]; other site 1138871007968 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1138871007969 RNA binding site [nucleotide binding]; other site 1138871007970 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1138871007971 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1138871007972 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871007973 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871007974 5'-3' exonuclease; Region: 53EXOc; smart00475 1138871007975 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1138871007976 active site 1138871007977 metal binding site 1 [ion binding]; metal-binding site 1138871007978 putative 5' ssDNA interaction site; other site 1138871007979 metal binding site 3; metal-binding site 1138871007980 metal binding site 2 [ion binding]; metal-binding site 1138871007981 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1138871007982 putative DNA binding site [nucleotide binding]; other site 1138871007983 putative metal binding site [ion binding]; other site 1138871007984 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1138871007985 DNA polymerase I; Provisional; Region: PRK05755 1138871007986 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1138871007987 active site 1138871007988 DNA binding site [nucleotide binding] 1138871007989 catalytic site [active] 1138871007990 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1138871007991 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1138871007992 lipid-transfer protein; Provisional; Region: PRK06059 1138871007993 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138871007994 active site 1138871007995 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1138871007996 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138871007997 active site 1138871007998 phosphorylation site [posttranslational modification] 1138871007999 intermolecular recognition site; other site 1138871008000 dimerization interface [polypeptide binding]; other site 1138871008001 ANTAR domain; Region: ANTAR; pfam03861 1138871008002 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1138871008003 cyclase homology domain; Region: CHD; cd07302 1138871008004 nucleotidyl binding site; other site 1138871008005 metal binding site [ion binding]; metal-binding site 1138871008006 dimer interface [polypeptide binding]; other site 1138871008007 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1138871008008 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1138871008009 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1138871008010 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1138871008011 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138871008012 Walker A/P-loop; other site 1138871008013 ATP binding site [chemical binding]; other site 1138871008014 ABC transporter; Region: ABC_tran; pfam00005 1138871008015 Q-loop/lid; other site 1138871008016 ABC transporter signature motif; other site 1138871008017 Walker B; other site 1138871008018 D-loop; other site 1138871008019 H-loop/switch region; other site 1138871008020 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 1138871008021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138871008022 Walker A/P-loop; other site 1138871008023 ATP binding site [chemical binding]; other site 1138871008024 Q-loop/lid; other site 1138871008025 ABC transporter signature motif; other site 1138871008026 Walker B; other site 1138871008027 D-loop; other site 1138871008028 H-loop/switch region; other site 1138871008029 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1138871008030 acyl-CoA thioesterase II; Region: tesB; TIGR00189 1138871008031 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1138871008032 active site 1138871008033 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1138871008034 catalytic triad [active] 1138871008035 dimer interface [polypeptide binding]; other site 1138871008036 pyruvate kinase; Provisional; Region: PRK06247 1138871008037 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1138871008038 active site 1138871008039 domain interfaces; other site 1138871008040 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 1138871008041 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK13108 1138871008042 Prolipoprotein diacylglyceryltransferase [Cell envelope biogenesis, outer membrane]; Region: Lgt; COG0682 1138871008043 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1138871008044 substrate binding site [chemical binding]; other site 1138871008045 active site 1138871008046 catalytic residues [active] 1138871008047 heterodimer interface [polypeptide binding]; other site 1138871008048 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1138871008049 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1138871008050 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138871008051 catalytic residue [active] 1138871008052 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1138871008053 active site 1138871008054 ribulose/triose binding site [chemical binding]; other site 1138871008055 phosphate binding site [ion binding]; other site 1138871008056 substrate (anthranilate) binding pocket [chemical binding]; other site 1138871008057 product (indole) binding pocket [chemical binding]; other site 1138871008058 Tryptophan-associated transmembrane protein (Trp_oprn_chp); Region: Trp_oprn_chp; pfam09534 1138871008059 anthranilate synthase component I; Provisional; Region: PRK13571 1138871008060 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1138871008061 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1138871008062 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1138871008063 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1138871008064 catalytic triad [active] 1138871008065 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 1138871008066 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1138871008067 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1138871008068 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1138871008069 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1138871008070 substrate binding site [chemical binding]; other site 1138871008071 glutamase interaction surface [polypeptide binding]; other site 1138871008072 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1138871008073 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1138871008074 active site 1138871008075 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1138871008076 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1138871008077 catalytic residues [active] 1138871008078 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1138871008079 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1138871008080 putative active site [active] 1138871008081 oxyanion strand; other site 1138871008082 catalytic triad [active] 1138871008083 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1138871008084 putative active site pocket [active] 1138871008085 4-fold oligomerization interface [polypeptide binding]; other site 1138871008086 metal binding residues [ion binding]; metal-binding site 1138871008087 3-fold/trimer interface [polypeptide binding]; other site 1138871008088 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1138871008089 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1138871008090 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138871008091 homodimer interface [polypeptide binding]; other site 1138871008092 catalytic residue [active] 1138871008093 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 1138871008094 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1138871008095 NAD binding site [chemical binding]; other site 1138871008096 dimerization interface [polypeptide binding]; other site 1138871008097 product binding site; other site 1138871008098 substrate binding site [chemical binding]; other site 1138871008099 zinc binding site [ion binding]; other site 1138871008100 catalytic residues [active] 1138871008101 Domain of unknown function (DUF385); Region: DUF385; cl04387 1138871008102 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 1138871008103 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1138871008104 dimerization interface [polypeptide binding]; other site 1138871008105 active site 1138871008106 L-aspartate oxidase; Provisional; Region: PRK07804 1138871008107 L-aspartate oxidase; Provisional; Region: PRK06175 1138871008108 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1138871008109 quinolinate synthetase; Provisional; Region: PRK09375 1138871008110 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1138871008111 nudix motif; other site 1138871008112 Secretory lipase; Region: LIP; pfam03583 1138871008113 Protein of unknown function (DUF2567); Region: DUF2567; pfam10821 1138871008114 biotin synthase; Validated; Region: PRK06256 1138871008115 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1138871008116 FeS/SAM binding site; other site 1138871008117 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1138871008118 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1138871008119 dimerization interface [polypeptide binding]; other site 1138871008120 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1138871008121 cyclase homology domain; Region: CHD; cd07302 1138871008122 nucleotidyl binding site; other site 1138871008123 metal binding site [ion binding]; metal-binding site 1138871008124 dimer interface [polypeptide binding]; other site 1138871008125 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1138871008126 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1138871008127 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1138871008128 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1138871008129 ligand binding site [chemical binding]; other site 1138871008130 flexible hinge region; other site 1138871008131 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1138871008132 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1138871008133 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1138871008134 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1138871008135 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1138871008136 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138871008137 catalytic residue [active] 1138871008138 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 1138871008139 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1138871008140 inhibitor-cofactor binding pocket; inhibition site 1138871008141 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138871008142 catalytic residue [active] 1138871008143 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1138871008144 NlpC/P60 family; Region: NLPC_P60; pfam00877 1138871008145 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1138871008146 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1138871008147 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1138871008148 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1138871008149 active site 1138871008150 catalytic site [active] 1138871008151 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 1138871008152 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1138871008153 active site 1138871008154 catalytic site [active] 1138871008155 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1138871008156 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1138871008157 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1138871008158 catalytic site [active] 1138871008159 active site 1138871008160 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1138871008161 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 1138871008162 active site 1138871008163 SUMO-1 interface [polypeptide binding]; other site 1138871008164 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 1138871008165 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138871008166 DNA-binding site [nucleotide binding]; DNA binding site 1138871008167 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1138871008168 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138871008169 homodimer interface [polypeptide binding]; other site 1138871008170 catalytic residue [active] 1138871008171 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1138871008172 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1138871008173 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1138871008174 active site 1138871008175 threonine dehydratase; Validated; Region: PRK08639 1138871008176 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1138871008177 tetramer interface [polypeptide binding]; other site 1138871008178 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138871008179 catalytic residue [active] 1138871008180 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1138871008181 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1138871008182 glycerol-3-phosphate acyltransferase; Reviewed; Region: PRK11915 1138871008183 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1138871008184 putative acyl-acceptor binding pocket; other site 1138871008185 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1138871008186 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1138871008187 acyl-activating enzyme (AAE) consensus motif; other site 1138871008188 putative AMP binding site [chemical binding]; other site 1138871008189 putative active site [active] 1138871008190 putative CoA binding site [chemical binding]; other site 1138871008191 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138871008192 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1138871008193 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 1138871008194 DNA binding residues [nucleotide binding] 1138871008195 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 1138871008196 putative dimer interface [polypeptide binding]; other site 1138871008197 putative metal binding residues [ion binding]; other site 1138871008198 PPOX class probable F420-dependent enzyme, Rv2061 family; Region: Rv2061_F420; TIGR03666 1138871008199 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1138871008200 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1138871008201 active site 1138871008202 PHP Thumb interface [polypeptide binding]; other site 1138871008203 metal binding site [ion binding]; metal-binding site 1138871008204 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1138871008205 generic binding surface II; other site 1138871008206 generic binding surface I; other site 1138871008207 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1138871008208 hydrophobic ligand binding site; other site 1138871008209 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1138871008210 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871008211 NAD(P) binding site [chemical binding]; other site 1138871008212 active site 1138871008213 classical (c) SDRs; Region: SDR_c; cd05233 1138871008214 NAD(P) binding site [chemical binding]; other site 1138871008215 active site 1138871008216 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1138871008217 heme-binding site [chemical binding]; other site 1138871008218 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1138871008219 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1138871008220 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871008221 S-adenosylmethionine binding site [chemical binding]; other site 1138871008222 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1138871008223 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1138871008224 active site 1138871008225 lipoprotein signal peptidase; Provisional; Region: PRK14764 1138871008226 lipoprotein signal peptidase; Provisional; Region: PRK14787 1138871008227 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1138871008228 active site 1138871008229 homodimer interface [polypeptide binding]; other site 1138871008230 homotetramer interface [polypeptide binding]; other site 1138871008231 DNA polymerase IV; Provisional; Region: PRK03348 1138871008232 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1138871008233 active site 1138871008234 DNA binding site [nucleotide binding] 1138871008235 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 1138871008236 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1138871008237 HIGH motif; other site 1138871008238 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1138871008239 active site 1138871008240 KMSKS motif; other site 1138871008241 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1138871008242 tRNA binding surface [nucleotide binding]; other site 1138871008243 anticodon binding site; other site 1138871008244 Nitronate monooxygenase; Region: NMO; pfam03060 1138871008245 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1138871008246 FMN binding site [chemical binding]; other site 1138871008247 substrate binding site [chemical binding]; other site 1138871008248 putative catalytic residue [active] 1138871008249 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1138871008250 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1138871008251 Condensation domain; Region: Condensation; pfam00668 1138871008252 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138871008253 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1138871008254 acyl-activating enzyme (AAE) consensus motif; other site 1138871008255 AMP binding site [chemical binding]; other site 1138871008256 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138871008257 Condensation domain; Region: Condensation; pfam00668 1138871008258 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138871008259 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138871008260 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138871008261 acyl-activating enzyme (AAE) consensus motif; other site 1138871008262 AMP binding site [chemical binding]; other site 1138871008263 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138871008264 peptide synthase; Provisional; Region: PRK12467 1138871008265 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138871008266 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138871008267 acyl-activating enzyme (AAE) consensus motif; other site 1138871008268 AMP binding site [chemical binding]; other site 1138871008269 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138871008270 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138871008271 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138871008272 acyl-activating enzyme (AAE) consensus motif; other site 1138871008273 AMP binding site [chemical binding]; other site 1138871008274 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138871008275 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1138871008276 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138871008277 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138871008278 acyl-activating enzyme (AAE) consensus motif; other site 1138871008279 AMP binding site [chemical binding]; other site 1138871008280 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138871008281 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138871008282 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138871008283 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138871008284 acyl-activating enzyme (AAE) consensus motif; other site 1138871008285 AMP binding site [chemical binding]; other site 1138871008286 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138871008287 Condensation domain; Region: Condensation; pfam00668 1138871008288 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138871008289 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138871008290 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138871008291 acyl-activating enzyme (AAE) consensus motif; other site 1138871008292 AMP binding site [chemical binding]; other site 1138871008293 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138871008294 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1138871008295 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1138871008296 putative NAD(P) binding site [chemical binding]; other site 1138871008297 active site 1138871008298 putative substrate binding site [chemical binding]; other site 1138871008299 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138871008300 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1138871008301 acyl-activating enzyme (AAE) consensus motif; other site 1138871008302 AMP binding site [chemical binding]; other site 1138871008303 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138871008304 Condensation domain; Region: Condensation; pfam00668 1138871008305 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1138871008306 Condensation domain; Region: Condensation; pfam00668 1138871008307 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138871008308 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138871008309 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138871008310 acyl-activating enzyme (AAE) consensus motif; other site 1138871008311 AMP binding site [chemical binding]; other site 1138871008312 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138871008313 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1138871008314 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1138871008315 putative NAD(P) binding site [chemical binding]; other site 1138871008316 active site 1138871008317 putative substrate binding site [chemical binding]; other site 1138871008318 Condensation domain; Region: Condensation; pfam00668 1138871008319 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138871008320 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1138871008321 acyl-activating enzyme (AAE) consensus motif; other site 1138871008322 AMP binding site [chemical binding]; other site 1138871008323 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138871008324 Condensation domain; Region: Condensation; pfam00668 1138871008325 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1138871008326 Condensation domain; Region: Condensation; pfam00668 1138871008327 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138871008328 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138871008329 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138871008330 acyl-activating enzyme (AAE) consensus motif; other site 1138871008331 AMP binding site [chemical binding]; other site 1138871008332 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138871008333 Condensation domain; Region: Condensation; pfam00668 1138871008334 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1138871008335 Condensation domain; Region: Condensation; pfam00668 1138871008336 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138871008337 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138871008338 MbtH-like protein; Region: MbtH; pfam03621 1138871008339 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1138871008340 Transport protein; Region: actII; TIGR00833 1138871008341 Transport protein; Region: actII; TIGR00833 1138871008342 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138871008343 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1138871008344 Walker A/P-loop; other site 1138871008345 ATP binding site [chemical binding]; other site 1138871008346 Q-loop/lid; other site 1138871008347 ABC transporter signature motif; other site 1138871008348 Walker B; other site 1138871008349 D-loop; other site 1138871008350 H-loop/switch region; other site 1138871008351 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1138871008352 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1138871008353 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1138871008354 daunorubicin resistance protein C; Region: drrC; TIGR01248 1138871008355 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1138871008356 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 1138871008357 metal-binding site 1138871008358 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1138871008359 NADP binding site [chemical binding]; other site 1138871008360 active site 1138871008361 putative substrate binding site [chemical binding]; other site 1138871008362 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1138871008363 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1138871008364 NADP-binding site; other site 1138871008365 homotetramer interface [polypeptide binding]; other site 1138871008366 substrate binding site [chemical binding]; other site 1138871008367 homodimer interface [polypeptide binding]; other site 1138871008368 active site 1138871008369 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1138871008370 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138871008371 Walker A motif; other site 1138871008372 ATP binding site [chemical binding]; other site 1138871008373 Walker B motif; other site 1138871008374 Homeodomain-like domain; Region: HTH_23; pfam13384 1138871008375 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1138871008376 Integrase core domain; Region: rve; pfam00665 1138871008377 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1138871008378 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1138871008379 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1138871008380 active site 1138871008381 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1138871008382 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1138871008383 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1138871008384 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1138871008385 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871008386 active site 1138871008387 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1138871008388 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1138871008389 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1138871008390 homodimer interface [polypeptide binding]; other site 1138871008391 active site 1138871008392 TDP-binding site; other site 1138871008393 acceptor substrate-binding pocket; other site 1138871008394 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1138871008395 classical (c) SDRs; Region: SDR_c; cd05233 1138871008396 NAD(P) binding site [chemical binding]; other site 1138871008397 active site 1138871008398 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1138871008399 Macrocin-O-methyltransferase (TylF); Region: TylF; pfam05711 1138871008400 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1138871008401 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1138871008402 homodimer interface [polypeptide binding]; other site 1138871008403 active site 1138871008404 TDP-binding site; other site 1138871008405 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1138871008406 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1138871008407 homodimer interface [polypeptide binding]; other site 1138871008408 active site 1138871008409 TDP-binding site; other site 1138871008410 acceptor substrate-binding pocket; other site 1138871008411 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1138871008412 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1138871008413 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871008414 NAD(P) binding site [chemical binding]; other site 1138871008415 active site 1138871008416 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 1138871008417 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 1138871008418 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1138871008419 Beta-lactamase; Region: Beta-lactamase; pfam00144 1138871008420 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1138871008421 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1138871008422 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1138871008423 Walker A; other site 1138871008424 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1138871008425 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1138871008426 active site 1138871008427 substrate binding site [chemical binding]; other site 1138871008428 coenzyme B12 binding site [chemical binding]; other site 1138871008429 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1138871008430 B12 binding site [chemical binding]; other site 1138871008431 cobalt ligand [ion binding]; other site 1138871008432 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 1138871008433 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 1138871008434 heterodimer interface [polypeptide binding]; other site 1138871008435 substrate interaction site [chemical binding]; other site 1138871008436 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1138871008437 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1138871008438 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1138871008439 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1138871008440 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1138871008441 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1138871008442 putative di-iron ligands [ion binding]; other site 1138871008443 Condensation domain; Region: Condensation; pfam00668 1138871008444 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138871008445 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1138871008446 acyl-activating enzyme (AAE) consensus motif; other site 1138871008447 AMP binding site [chemical binding]; other site 1138871008448 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138871008449 Condensation domain; Region: Condensation; pfam00668 1138871008450 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1138871008451 Condensation domain; Region: Condensation; pfam00668 1138871008452 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1138871008453 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1138871008454 acyl-activating enzyme (AAE) consensus motif; other site 1138871008455 AMP binding site [chemical binding]; other site 1138871008456 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138871008457 Condensation domain; Region: Condensation; pfam00668 1138871008458 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1138871008459 Condensation domain; Region: Condensation; pfam00668 1138871008460 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1138871008461 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1138871008462 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1138871008463 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1138871008464 dimerization interface [polypeptide binding]; other site 1138871008465 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1138871008466 dimer interface [polypeptide binding]; other site 1138871008467 phosphorylation site [posttranslational modification] 1138871008468 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138871008469 Mg2+ binding site [ion binding]; other site 1138871008470 G-X-G motif; other site 1138871008471 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1138871008472 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138871008473 active site 1138871008474 phosphorylation site [posttranslational modification] 1138871008475 intermolecular recognition site; other site 1138871008476 dimerization interface [polypeptide binding]; other site 1138871008477 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1138871008478 DNA binding site [nucleotide binding] 1138871008479 Domain of unknown function (DUF385); Region: DUF385; cl04387 1138871008480 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1138871008481 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1138871008482 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1138871008483 ferrochelatase; Reviewed; Region: hemH; PRK00035 1138871008484 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1138871008485 C-terminal domain interface [polypeptide binding]; other site 1138871008486 active site 1138871008487 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1138871008488 active site 1138871008489 N-terminal domain interface [polypeptide binding]; other site 1138871008490 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 1138871008491 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1138871008492 NAD binding site [chemical binding]; other site 1138871008493 homotetramer interface [polypeptide binding]; other site 1138871008494 homodimer interface [polypeptide binding]; other site 1138871008495 substrate binding site [chemical binding]; other site 1138871008496 active site 1138871008497 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1138871008498 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1138871008499 NAD(P) binding site [chemical binding]; other site 1138871008500 homotetramer interface [polypeptide binding]; other site 1138871008501 homodimer interface [polypeptide binding]; other site 1138871008502 active site 1138871008503 Helix-turn-helix domain; Region: HTH_38; pfam13936 1138871008504 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1138871008505 Integrase core domain; Region: rve; pfam00665 1138871008506 hypothetical protein; Provisional; Region: PRK13685 1138871008507 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1138871008508 metal ion-dependent adhesion site (MIDAS); other site 1138871008509 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1138871008510 Protein of unknown function DUF58; Region: DUF58; pfam01882 1138871008511 MoxR-like ATPases [General function prediction only]; Region: COG0714 1138871008512 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138871008513 Walker A motif; other site 1138871008514 ATP binding site [chemical binding]; other site 1138871008515 Walker B motif; other site 1138871008516 arginine finger; other site 1138871008517 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1138871008518 NlpC/P60 family; Region: NLPC_P60; pfam00877 1138871008519 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1138871008520 NlpC/P60 family; Region: NLPC_P60; pfam00877 1138871008521 aconitate hydratase; Validated; Region: PRK09277 1138871008522 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1138871008523 substrate binding site [chemical binding]; other site 1138871008524 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1138871008525 ligand binding site [chemical binding]; other site 1138871008526 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1138871008527 substrate binding site [chemical binding]; other site 1138871008528 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871008529 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871008530 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1138871008531 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138871008532 Walker A/P-loop; other site 1138871008533 ATP binding site [chemical binding]; other site 1138871008534 Q-loop/lid; other site 1138871008535 ABC transporter signature motif; other site 1138871008536 Walker B; other site 1138871008537 D-loop; other site 1138871008538 H-loop/switch region; other site 1138871008539 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1138871008540 enoyl-CoA hydratase; Provisional; Region: PRK05864 1138871008541 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138871008542 substrate binding site [chemical binding]; other site 1138871008543 oxyanion hole (OAH) forming residues; other site 1138871008544 trimer interface [polypeptide binding]; other site 1138871008545 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1138871008546 catalytic residues [active] 1138871008547 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1138871008548 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1138871008549 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871008550 active site 1138871008551 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1138871008552 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1138871008553 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871008554 NAD(P) binding site [chemical binding]; other site 1138871008555 active site 1138871008556 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_like_4; cd06152 1138871008557 homotrimer interaction site [polypeptide binding]; other site 1138871008558 putative active site [active] 1138871008559 Cupin domain; Region: Cupin_2; pfam07883 1138871008560 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1138871008561 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138871008562 classical (c) SDRs; Region: SDR_c; cd05233 1138871008563 NAD(P) binding site [chemical binding]; other site 1138871008564 active site 1138871008565 Transport protein; Region: actII; TIGR00833 1138871008566 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1138871008567 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871008568 S-adenosylmethionine binding site [chemical binding]; other site 1138871008569 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138871008570 putative substrate translocation pore; other site 1138871008571 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138871008572 Nitroreductase family; Region: Nitroreductase; pfam00881 1138871008573 FMN binding site [chemical binding]; other site 1138871008574 dimer interface [polypeptide binding]; other site 1138871008575 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 1138871008576 homotrimer interaction site [polypeptide binding]; other site 1138871008577 putative active site [active] 1138871008578 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1138871008579 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1138871008580 putative NAD(P) binding site [chemical binding]; other site 1138871008581 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1138871008582 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138871008583 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1138871008584 Cupin domain; Region: Cupin_2; cl17218 1138871008585 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1138871008586 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1138871008587 putative NAD(P) binding site [chemical binding]; other site 1138871008588 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871008589 PPE family; Region: PPE; pfam00823 1138871008590 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138871008591 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138871008592 Protein of unknown function (DUF2424); Region: DUF2424; pfam10340 1138871008593 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138871008594 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1138871008595 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1138871008596 DNA-binding interface [nucleotide binding]; DNA binding site 1138871008597 AAA ATPase domain; Region: AAA_16; pfam13191 1138871008598 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1138871008599 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1138871008600 DNA binding residues [nucleotide binding] 1138871008601 dimerization interface [polypeptide binding]; other site 1138871008602 AAA ATPase domain; Region: AAA_16; pfam13191 1138871008603 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1138871008604 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1138871008605 DNA binding residues [nucleotide binding] 1138871008606 dimerization interface [polypeptide binding]; other site 1138871008607 transcriptional regulator MalT; Provisional; Region: PRK04841 1138871008608 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1138871008609 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1138871008610 binding surface 1138871008611 TPR motif; other site 1138871008612 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1138871008613 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1138871008614 DNA binding residues [nucleotide binding] 1138871008615 dimerization interface [polypeptide binding]; other site 1138871008616 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 1138871008617 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138871008618 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138871008619 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1138871008620 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1138871008621 putative active site [active] 1138871008622 transaldolase; Provisional; Region: PRK03903 1138871008623 catalytic residue [active] 1138871008624 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1138871008625 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 1138871008626 Moco binding site; other site 1138871008627 metal coordination site [ion binding]; other site 1138871008628 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1138871008629 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 1138871008630 FAD binding pocket [chemical binding]; other site 1138871008631 FAD binding motif [chemical binding]; other site 1138871008632 phosphate binding motif [ion binding]; other site 1138871008633 beta-alpha-beta structure motif; other site 1138871008634 NAD binding pocket [chemical binding]; other site 1138871008635 DNL zinc finger; Region: zf-DNL; pfam05180 1138871008636 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 1138871008637 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1138871008638 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1138871008639 Protein of unknown function, DUF417; Region: DUF417; cl01162 1138871008640 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1138871008641 classical (c) SDRs; Region: SDR_c; cd05233 1138871008642 NAD(P) binding site [chemical binding]; other site 1138871008643 active site 1138871008644 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1138871008645 SelR domain; Region: SelR; pfam01641 1138871008646 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1138871008647 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1138871008648 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1138871008649 D-pathway; other site 1138871008650 Putative ubiquinol binding site [chemical binding]; other site 1138871008651 Low-spin heme (heme b) binding site [chemical binding]; other site 1138871008652 Putative water exit pathway; other site 1138871008653 Binuclear center (heme o3/CuB) [ion binding]; other site 1138871008654 K-pathway; other site 1138871008655 Putative proton exit pathway; other site 1138871008656 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1138871008657 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138871008658 Predicted membrane protein [Function unknown]; Region: COG2323 1138871008659 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1138871008660 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1138871008661 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1138871008662 trimerization site [polypeptide binding]; other site 1138871008663 active site 1138871008664 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1138871008665 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1138871008666 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138871008667 catalytic residue [active] 1138871008668 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1138871008669 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1138871008670 Walker A/P-loop; other site 1138871008671 ATP binding site [chemical binding]; other site 1138871008672 Q-loop/lid; other site 1138871008673 ABC transporter signature motif; other site 1138871008674 Walker B; other site 1138871008675 D-loop; other site 1138871008676 H-loop/switch region; other site 1138871008677 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1138871008678 FeS assembly protein SufD; Region: sufD; TIGR01981 1138871008679 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1138871008680 FeS assembly protein SufB; Region: sufB; TIGR01980 1138871008681 Predicted transcriptional regulator [Transcription]; Region: COG2345 1138871008682 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1138871008683 putative DNA binding site [nucleotide binding]; other site 1138871008684 putative Zn2+ binding site [ion binding]; other site 1138871008685 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 1138871008686 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1138871008687 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1138871008688 Walker A/P-loop; other site 1138871008689 ATP binding site [chemical binding]; other site 1138871008690 Q-loop/lid; other site 1138871008691 ABC transporter signature motif; other site 1138871008692 Walker B; other site 1138871008693 D-loop; other site 1138871008694 H-loop/switch region; other site 1138871008695 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1138871008696 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1138871008697 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1138871008698 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1138871008699 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1138871008700 NADP binding site [chemical binding]; other site 1138871008701 dimer interface [polypeptide binding]; other site 1138871008702 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1138871008703 UbiA prenyltransferase family; Region: UbiA; pfam01040 1138871008704 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1138871008705 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1138871008706 TPP-binding site [chemical binding]; other site 1138871008707 dimer interface [polypeptide binding]; other site 1138871008708 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1138871008709 PYR/PP interface [polypeptide binding]; other site 1138871008710 dimer interface [polypeptide binding]; other site 1138871008711 TPP binding site [chemical binding]; other site 1138871008712 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1138871008713 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1138871008714 putative active site [active] 1138871008715 transaldolase; Provisional; Region: PRK03903 1138871008716 catalytic residue [active] 1138871008717 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1138871008718 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1138871008719 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1138871008720 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1138871008721 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 1138871008722 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1138871008723 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1138871008724 putative active site [active] 1138871008725 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1138871008726 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 1138871008727 putative active site [active] 1138871008728 Zn binding site [ion binding]; other site 1138871008729 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1138871008730 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1138871008731 active site 1138871008732 catalytic tetrad [active] 1138871008733 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1138871008734 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1138871008735 Preprotein translocase SecG subunit; Region: SecG; cl09123 1138871008736 triosephosphate isomerase; Provisional; Region: PRK14567 1138871008737 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1138871008738 substrate binding site [chemical binding]; other site 1138871008739 dimer interface [polypeptide binding]; other site 1138871008740 catalytic triad [active] 1138871008741 Phosphoglycerate kinase; Region: PGK; pfam00162 1138871008742 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1138871008743 substrate binding site [chemical binding]; other site 1138871008744 hinge regions; other site 1138871008745 ADP binding site [chemical binding]; other site 1138871008746 catalytic site [active] 1138871008747 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1138871008748 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1138871008749 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1138871008750 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1138871008751 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138871008752 Transmembrane protein of unknown function (DUF3556); Region: DUF3556; pfam12077 1138871008753 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1138871008754 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1138871008755 putative acyl-acceptor binding pocket; other site 1138871008756 acyl-CoA synthetase; Provisional; Region: PRK13382 1138871008757 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871008758 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1138871008759 acyl-activating enzyme (AAE) consensus motif; other site 1138871008760 putative AMP binding site [chemical binding]; other site 1138871008761 putative active site [active] 1138871008762 putative CoA binding site [chemical binding]; other site 1138871008763 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1138871008764 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1138871008765 substrate binding pocket [chemical binding]; other site 1138871008766 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138871008767 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138871008768 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138871008769 active site 1138871008770 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138871008771 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1138871008772 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1138871008773 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1138871008774 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1138871008775 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1138871008776 phosphate binding site [ion binding]; other site 1138871008777 putative substrate binding pocket [chemical binding]; other site 1138871008778 dimer interface [polypeptide binding]; other site 1138871008779 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1138871008780 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1138871008781 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1138871008782 GIY-YIG motif/motif A; other site 1138871008783 active site 1138871008784 catalytic site [active] 1138871008785 putative DNA binding site [nucleotide binding]; other site 1138871008786 metal binding site [ion binding]; metal-binding site 1138871008787 UvrB/uvrC motif; Region: UVR; pfam02151 1138871008788 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1138871008789 Helix-hairpin-helix motif; Region: HHH; pfam00633 1138871008790 Cupin superfamily protein; Region: Cupin_4; pfam08007 1138871008791 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871008792 PPE family; Region: PPE; pfam00823 1138871008793 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1138871008794 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1138871008795 homopentamer interface [polypeptide binding]; other site 1138871008796 active site 1138871008797 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1138871008798 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1138871008799 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1138871008800 dimerization interface [polypeptide binding]; other site 1138871008801 active site 1138871008802 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1138871008803 Lumazine binding domain; Region: Lum_binding; pfam00677 1138871008804 Lumazine binding domain; Region: Lum_binding; pfam00677 1138871008805 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 1138871008806 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138871008807 putative substrate translocation pore; other site 1138871008808 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138871008809 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1138871008810 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1138871008811 catalytic motif [active] 1138871008812 Zn binding site [ion binding]; other site 1138871008813 RibD C-terminal domain; Region: RibD_C; pfam01872 1138871008814 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1138871008815 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1138871008816 substrate binding site [chemical binding]; other site 1138871008817 hexamer interface [polypeptide binding]; other site 1138871008818 metal binding site [ion binding]; metal-binding site 1138871008819 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1138871008820 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1138871008821 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871008822 S-adenosylmethionine binding site [chemical binding]; other site 1138871008823 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1138871008824 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1138871008825 putative active site [active] 1138871008826 substrate binding site [chemical binding]; other site 1138871008827 putative cosubstrate binding site; other site 1138871008828 catalytic site [active] 1138871008829 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1138871008830 substrate binding site [chemical binding]; other site 1138871008831 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871008832 S-adenosylmethionine binding site [chemical binding]; other site 1138871008833 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1138871008834 MarR family; Region: MarR; pfam01047 1138871008835 primosome assembly protein PriA; Provisional; Region: PRK14873 1138871008836 primosome assembly protein PriA; Provisional; Region: PRK14873 1138871008837 Predicted membrane protein [Function unknown]; Region: COG3714 1138871008838 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1138871008839 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138871008840 substrate binding pocket [chemical binding]; other site 1138871008841 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138871008842 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138871008843 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1138871008844 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1138871008845 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1138871008846 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1138871008847 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1138871008848 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1138871008849 Flavoprotein; Region: Flavoprotein; pfam02441 1138871008850 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1138871008851 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1138871008852 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1138871008853 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1138871008854 catalytic site [active] 1138871008855 G-X2-G-X-G-K; other site 1138871008856 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1138871008857 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1138871008858 DNA binding residues [nucleotide binding] 1138871008859 TOBE domain; Region: TOBE; cl01440 1138871008860 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1138871008861 active site 1138871008862 dimer interface [polypeptide binding]; other site 1138871008863 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1138871008864 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1138871008865 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1138871008866 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1138871008867 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1138871008868 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1138871008869 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1138871008870 IMP binding site; other site 1138871008871 dimer interface [polypeptide binding]; other site 1138871008872 interdomain contacts; other site 1138871008873 partial ornithine binding site; other site 1138871008874 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1138871008875 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1138871008876 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1138871008877 catalytic site [active] 1138871008878 subunit interface [polypeptide binding]; other site 1138871008879 dihydroorotase; Validated; Region: pyrC; PRK09357 1138871008880 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138871008881 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1138871008882 active site 1138871008883 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1138871008884 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1138871008885 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1138871008886 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 1138871008887 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1138871008888 active site 1138871008889 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1138871008890 Beta-lactamase; Region: Beta-lactamase; pfam00144 1138871008891 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1138871008892 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1138871008893 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 1138871008894 L-aspartate oxidase; Provisional; Region: PRK06175 1138871008895 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1138871008896 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1138871008897 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1138871008898 Walker A/P-loop; other site 1138871008899 ATP binding site [chemical binding]; other site 1138871008900 Q-loop/lid; other site 1138871008901 ABC transporter signature motif; other site 1138871008902 Walker B; other site 1138871008903 D-loop; other site 1138871008904 H-loop/switch region; other site 1138871008905 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1138871008906 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138871008907 dimer interface [polypeptide binding]; other site 1138871008908 conserved gate region; other site 1138871008909 putative PBP binding loops; other site 1138871008910 ABC-ATPase subunit interface; other site 1138871008911 taurine ABC transporter, periplasmic binding protein; Region: taurine_ABC_bnd; TIGR01729 1138871008912 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1138871008913 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1138871008914 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1138871008915 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138871008916 DNA-binding site [nucleotide binding]; DNA binding site 1138871008917 UTRA domain; Region: UTRA; pfam07702 1138871008918 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1138871008919 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1138871008920 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138871008921 catalytic residue [active] 1138871008922 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1138871008923 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1138871008924 putative RNA binding site [nucleotide binding]; other site 1138871008925 elongation factor P; Validated; Region: PRK00529 1138871008926 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1138871008927 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1138871008928 RNA binding site [nucleotide binding]; other site 1138871008929 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1138871008930 RNA binding site [nucleotide binding]; other site 1138871008931 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1138871008932 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1138871008933 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1138871008934 active site 1138871008935 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1138871008936 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1138871008937 trimer interface [polypeptide binding]; other site 1138871008938 active site 1138871008939 dimer interface [polypeptide binding]; other site 1138871008940 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1138871008941 active site 1138871008942 dimer interface [polypeptide binding]; other site 1138871008943 metal binding site [ion binding]; metal-binding site 1138871008944 shikimate kinase; Reviewed; Region: aroK; PRK00131 1138871008945 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1138871008946 ADP binding site [chemical binding]; other site 1138871008947 magnesium binding site [ion binding]; other site 1138871008948 putative shikimate binding site; other site 1138871008949 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1138871008950 chorismate synthase; Validated; Region: PRK05382 1138871008951 Tetramer interface [polypeptide binding]; other site 1138871008952 active site 1138871008953 FMN-binding site [chemical binding]; other site 1138871008954 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 1138871008955 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1138871008956 active site 1138871008957 dimer interface [polypeptide binding]; other site 1138871008958 non-prolyl cis peptide bond; other site 1138871008959 insertion regions; other site 1138871008960 shikimate-5-dehydrogenase, fungal AROM-type; Region: Shik-DH-AROM; TIGR01809 1138871008961 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1138871008962 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1138871008963 shikimate binding site; other site 1138871008964 NAD(P) binding site [chemical binding]; other site 1138871008965 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 1138871008966 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1138871008967 dimerization interface [polypeptide binding]; other site 1138871008968 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1138871008969 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1138871008970 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1138871008971 motif 1; other site 1138871008972 active site 1138871008973 motif 2; other site 1138871008974 motif 3; other site 1138871008975 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1138871008976 DHHA1 domain; Region: DHHA1; pfam02272 1138871008977 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1138871008978 recombination factor protein RarA; Reviewed; Region: PRK13342 1138871008979 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138871008980 Walker A motif; other site 1138871008981 ATP binding site [chemical binding]; other site 1138871008982 Walker B motif; other site 1138871008983 arginine finger; other site 1138871008984 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1138871008985 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 1138871008986 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 1138871008987 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1138871008988 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1138871008989 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 1138871008990 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 1138871008991 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1138871008992 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1138871008993 Transglutaminase/protease-like homologues; Region: TGc; smart00460 1138871008994 Protein of unknown function (DUF419); Region: DUF419; cl15265 1138871008995 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1138871008996 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1138871008997 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1138871008998 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1138871008999 dimer interface [polypeptide binding]; other site 1138871009000 anticodon binding site; other site 1138871009001 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1138871009002 homodimer interface [polypeptide binding]; other site 1138871009003 motif 1; other site 1138871009004 active site 1138871009005 motif 2; other site 1138871009006 GAD domain; Region: GAD; pfam02938 1138871009007 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1138871009008 active site 1138871009009 motif 3; other site 1138871009010 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1138871009011 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1138871009012 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1138871009013 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1138871009014 putative hydrophobic ligand binding site [chemical binding]; other site 1138871009015 protein interface [polypeptide binding]; other site 1138871009016 gate; other site 1138871009017 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1138871009018 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1138871009019 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1138871009020 inhibitor site; inhibition site 1138871009021 active site 1138871009022 dimer interface [polypeptide binding]; other site 1138871009023 catalytic residue [active] 1138871009024 class II aldolase/adducin domain protein; Provisional; Region: PRK07090 1138871009025 intersubunit interface [polypeptide binding]; other site 1138871009026 active site 1138871009027 Zn2+ binding site [ion binding]; other site 1138871009028 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1138871009029 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1138871009030 non-specific DNA binding site [nucleotide binding]; other site 1138871009031 salt bridge; other site 1138871009032 sequence-specific DNA binding site [nucleotide binding]; other site 1138871009033 Cupin domain; Region: Cupin_2; pfam07883 1138871009034 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1138871009035 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1138871009036 active site 1138871009037 metal binding site [ion binding]; metal-binding site 1138871009038 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1138871009039 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1138871009040 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1138871009041 hydrophobic ligand binding site; other site 1138871009042 Cation efflux family; Region: Cation_efflux; cl00316 1138871009043 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1138871009044 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 1138871009045 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871009046 PPE family; Region: PPE; pfam00823 1138871009047 PE family; Region: PE; pfam00934 1138871009048 multidrug resistance protein MdtH; Provisional; Region: PRK11646 1138871009049 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1138871009050 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1138871009051 dimer interface [polypeptide binding]; other site 1138871009052 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138871009053 catalytic residue [active] 1138871009054 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1138871009055 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1138871009056 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138871009057 catalytic residue [active] 1138871009058 Transposase; Region: HTH_Tnp_1; cl17663 1138871009059 putative transposase OrfB; Reviewed; Region: PHA02517 1138871009060 HTH-like domain; Region: HTH_21; pfam13276 1138871009061 Integrase core domain; Region: rve; pfam00665 1138871009062 Integrase core domain; Region: rve_3; cl15866 1138871009063 PE family; Region: PE; pfam00934 1138871009064 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871009065 PPE family; Region: PPE; pfam00823 1138871009066 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138871009067 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1138871009068 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1138871009069 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1138871009070 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1138871009071 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1138871009072 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871009073 PPE family; Region: PPE; pfam00823 1138871009074 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138871009075 PE family; Region: PE; pfam00934 1138871009076 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871009077 PPE family; Region: PPE; pfam00823 1138871009078 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138871009079 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1138871009080 active site 1138871009081 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 1138871009082 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1138871009083 putative active site [active] 1138871009084 putative NTP binding site [chemical binding]; other site 1138871009085 putative nucleic acid binding site [nucleotide binding]; other site 1138871009086 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1138871009087 Winged helix-turn helix; Region: HTH_29; pfam13551 1138871009088 Helix-turn-helix domain; Region: HTH_28; pfam13518 1138871009089 Homeodomain-like domain; Region: HTH_32; pfam13565 1138871009090 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1138871009091 Integrase core domain; Region: rve; pfam00665 1138871009092 Integrase core domain; Region: rve_3; pfam13683 1138871009093 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1138871009094 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1138871009095 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1138871009096 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138871009097 active site 1138871009098 motif I; other site 1138871009099 motif II; other site 1138871009100 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1138871009101 MgtE intracellular N domain; Region: MgtE_N; smart00924 1138871009102 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1138871009103 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1138871009104 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1138871009105 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1138871009106 heme bH binding site [chemical binding]; other site 1138871009107 intrachain domain interface; other site 1138871009108 heme bL binding site [chemical binding]; other site 1138871009109 interchain domain interface [polypeptide binding]; other site 1138871009110 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 1138871009111 Qo binding site; other site 1138871009112 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1138871009113 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1138871009114 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 1138871009115 nudix motif; other site 1138871009116 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1138871009117 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1138871009118 non-specific DNA binding site [nucleotide binding]; other site 1138871009119 salt bridge; other site 1138871009120 sequence-specific DNA binding site [nucleotide binding]; other site 1138871009121 PLD-like domain; Region: PLDc_2; pfam13091 1138871009122 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cd00138 1138871009123 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138871009124 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1138871009125 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1138871009126 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1138871009127 non-specific DNA binding site [nucleotide binding]; other site 1138871009128 salt bridge; other site 1138871009129 sequence-specific DNA binding site [nucleotide binding]; other site 1138871009130 Domain of unknown function (DUF955); Region: DUF955; cl01076 1138871009131 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1138871009132 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1138871009133 catalytic residues [active] 1138871009134 Recombinase; Region: Recombinase; pfam07508 1138871009135 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138871009136 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138871009137 active site 1138871009138 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1138871009139 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1138871009140 dimer interface [polypeptide binding]; other site 1138871009141 motif 1; other site 1138871009142 active site 1138871009143 motif 2; other site 1138871009144 motif 3; other site 1138871009145 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1138871009146 anticodon binding site; other site 1138871009147 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1138871009148 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1138871009149 active site 1138871009150 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 1138871009151 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1138871009152 Zn2+ binding site [ion binding]; other site 1138871009153 Mg2+ binding site [ion binding]; other site 1138871009154 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1138871009155 synthetase active site [active] 1138871009156 NTP binding site [chemical binding]; other site 1138871009157 metal binding site [ion binding]; metal-binding site 1138871009158 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1138871009159 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1138871009160 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1138871009161 active site 1138871009162 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1138871009163 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1138871009164 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1138871009165 Protein export membrane protein; Region: SecD_SecF; pfam02355 1138871009166 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1138871009167 Protein export membrane protein; Region: SecD_SecF; cl14618 1138871009168 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05886 1138871009169 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 1138871009170 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1138871009171 inhibitor-cofactor binding pocket; inhibition site 1138871009172 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138871009173 catalytic residue [active] 1138871009174 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1138871009175 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871009176 acyl-activating enzyme (AAE) consensus motif; other site 1138871009177 AMP binding site [chemical binding]; other site 1138871009178 active site 1138871009179 CoA binding site [chemical binding]; other site 1138871009180 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1138871009181 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1138871009182 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1138871009183 putative NAD(P) binding site [chemical binding]; other site 1138871009184 active site 1138871009185 putative substrate binding site [chemical binding]; other site 1138871009186 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1138871009187 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1138871009188 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138871009189 Walker A motif; other site 1138871009190 ATP binding site [chemical binding]; other site 1138871009191 Walker B motif; other site 1138871009192 arginine finger; other site 1138871009193 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1138871009194 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1138871009195 RuvA N terminal domain; Region: RuvA_N; pfam01330 1138871009196 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1138871009197 active site 1138871009198 putative DNA-binding cleft [nucleotide binding]; other site 1138871009199 dimer interface [polypeptide binding]; other site 1138871009200 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 1138871009201 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 1138871009202 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 1138871009203 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1138871009204 spermidine synthase; Provisional; Region: PRK03612 1138871009205 Spermine/spermidine synthase; Region: Spermine_synth; pfam01564 1138871009206 hypothetical protein; Validated; Region: PRK00110 1138871009207 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1138871009208 predicted active site [active] 1138871009209 catalytic triad [active] 1138871009210 acyl-CoA thioesterase II; Region: tesB; TIGR00189 1138871009211 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1138871009212 active site 1138871009213 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1138871009214 catalytic triad [active] 1138871009215 dimer interface [polypeptide binding]; other site 1138871009216 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1138871009217 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1138871009218 active site 1138871009219 multimer interface [polypeptide binding]; other site 1138871009220 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 1138871009221 nudix motif; other site 1138871009222 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1138871009223 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1138871009224 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1138871009225 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1138871009226 putative acyl-acceptor binding pocket; other site 1138871009227 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1138871009228 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 1138871009229 nucleotide binding site/active site [active] 1138871009230 HIT family signature motif; other site 1138871009231 catalytic residue [active] 1138871009232 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1138871009233 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1138871009234 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1138871009235 active site 1138871009236 dimer interface [polypeptide binding]; other site 1138871009237 motif 1; other site 1138871009238 motif 2; other site 1138871009239 motif 3; other site 1138871009240 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1138871009241 anticodon binding site; other site 1138871009242 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1138871009243 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1138871009244 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 1138871009245 metal binding site [ion binding]; metal-binding site 1138871009246 putative dimer interface [polypeptide binding]; other site 1138871009247 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1138871009248 CoenzymeA binding site [chemical binding]; other site 1138871009249 subunit interaction site [polypeptide binding]; other site 1138871009250 PHB binding site; other site 1138871009251 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1138871009252 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1138871009253 active site 1138871009254 catalytic tetrad [active] 1138871009255 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 1138871009256 Helix-turn-helix domain; Region: HTH_20; pfam12840 1138871009257 putative DNA binding site [nucleotide binding]; other site 1138871009258 Predicted transcriptional regulator [Transcription]; Region: COG2345 1138871009259 putative Zn2+ binding site [ion binding]; other site 1138871009260 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1138871009261 FMN binding site [chemical binding]; other site 1138871009262 substrate binding site [chemical binding]; other site 1138871009263 putative catalytic residue [active] 1138871009264 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1138871009265 Predicted transcriptional regulator [Transcription]; Region: COG2345 1138871009266 Helix-turn-helix domain; Region: HTH_20; pfam12840 1138871009267 putative DNA binding site [nucleotide binding]; other site 1138871009268 putative Zn2+ binding site [ion binding]; other site 1138871009269 Ferredoxin [Energy production and conversion]; Region: COG1146 1138871009270 4Fe-4S binding domain; Region: Fer4; pfam00037 1138871009271 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871009272 S-adenosylmethionine binding site [chemical binding]; other site 1138871009273 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1138871009274 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1138871009275 tetramer interface [polypeptide binding]; other site 1138871009276 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1138871009277 active site 1138871009278 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1138871009279 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 1138871009280 active site 1138871009281 Hemerythrin-like domain; Region: Hr-like; cd12108 1138871009282 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 1138871009283 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1138871009284 iron-sulfur cluster [ion binding]; other site 1138871009285 [2Fe-2S] cluster binding site [ion binding]; other site 1138871009286 Rieske non-heme iron oxygenase (RO) family, Nathphalene 1,2-dioxygenase (NDO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; ROs comprise a large class of aromatic ring-hydroxylating dioxygenases that enable microorganisms to...; Region: Rieske_RO_Alpha_NDO; cd03535 1138871009287 alpha subunit interaction site [polypeptide binding]; other site 1138871009288 beta subunit interaction site [polypeptide binding]; other site 1138871009289 iron-sulfur cluster [ion binding]; other site 1138871009290 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 1138871009291 beta subunit interface [polypeptide binding]; other site 1138871009292 alpha subunit interface [polypeptide binding]; other site 1138871009293 active site 1138871009294 substrate binding site [chemical binding]; other site 1138871009295 Fe binding site [ion binding]; other site 1138871009296 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1138871009297 inter-subunit interface; other site 1138871009298 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 1138871009299 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871009300 NAD(P) binding site [chemical binding]; other site 1138871009301 active site 1138871009302 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 1138871009303 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1138871009304 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1138871009305 Bacterial transcriptional regulator; Region: IclR; pfam01614 1138871009306 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1138871009307 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1138871009308 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871009309 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871009310 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1138871009311 anti sigma factor interaction site; other site 1138871009312 regulatory phosphorylation site [posttranslational modification]; other site 1138871009313 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1138871009314 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1138871009315 Predicted permeases [General function prediction only]; Region: COG0730 1138871009316 Catalase-like heme-binding proteins similar to the uncharacterized srpA; Region: srpA_like; cd08153 1138871009317 putative heme binding pocket [chemical binding]; other site 1138871009318 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138871009319 classical (c) SDRs; Region: SDR_c; cd05233 1138871009320 NAD(P) binding site [chemical binding]; other site 1138871009321 active site 1138871009322 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871009323 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1138871009324 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871009325 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1138871009326 acyl-activating enzyme (AAE) consensus motif; other site 1138871009327 acyl-activating enzyme (AAE) consensus motif; other site 1138871009328 putative AMP binding site [chemical binding]; other site 1138871009329 putative active site [active] 1138871009330 putative CoA binding site [chemical binding]; other site 1138871009331 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138871009332 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138871009333 substrate binding site [chemical binding]; other site 1138871009334 oxyanion hole (OAH) forming residues; other site 1138871009335 trimer interface [polypeptide binding]; other site 1138871009336 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1138871009337 hydrophobic ligand binding site; other site 1138871009338 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1138871009339 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1138871009340 active site 1138871009341 catalytic residues [active] 1138871009342 DNA binding site [nucleotide binding] 1138871009343 Int/Topo IB signature motif; other site 1138871009344 Helix-turn-helix domain; Region: HTH_17; pfam12728 1138871009345 Helix-turn-helix domain; Region: HTH_17; pfam12728 1138871009346 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1138871009347 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 1138871009348 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1138871009349 Phage Terminase; Region: Terminase_1; pfam03354 1138871009350 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1138871009351 Phage portal protein; Region: Phage_portal; pfam04860 1138871009352 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 1138871009353 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1138871009354 Phage capsid family; Region: Phage_capsid; pfam05065 1138871009355 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138871009356 Predicted membrane protein (DUF2335); Region: DUF2335; cl02210 1138871009357 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 1138871009358 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1138871009359 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1138871009360 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138871009361 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138871009362 Acetoacetate decarboxylase (ADC); Region: ADC; pfam06314 1138871009363 classical (c) SDRs; Region: SDR_c; cd05233 1138871009364 NAD(P) binding site [chemical binding]; other site 1138871009365 active site 1138871009366 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1138871009367 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1138871009368 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138871009369 Domain of unknown function (DUF4189); Region: DUF4189; pfam13827 1138871009370 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138871009371 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871009372 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871009373 short chain dehydrogenase; Provisional; Region: PRK12827 1138871009374 classical (c) SDRs; Region: SDR_c; cd05233 1138871009375 NAD(P) binding site [chemical binding]; other site 1138871009376 active site 1138871009377 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1138871009378 classical (c) SDRs; Region: SDR_c; cd05233 1138871009379 NAD(P) binding site [chemical binding]; other site 1138871009380 active site 1138871009381 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1138871009382 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1138871009383 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138871009384 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1138871009385 NAD(P) binding site [chemical binding]; other site 1138871009386 catalytic residues [active] 1138871009387 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1138871009388 Cation efflux family; Region: Cation_efflux; cl00316 1138871009389 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138871009390 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138871009391 Clp amino terminal domain; Region: Clp_N; pfam02861 1138871009392 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1138871009393 Coenzyme A binding pocket [chemical binding]; other site 1138871009394 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 1138871009395 hypothetical protein; Provisional; Region: PRK14059 1138871009396 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 1138871009397 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138871009398 TAP-like protein; Region: Abhydrolase_4; pfam08386 1138871009399 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1138871009400 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 1138871009401 SelR domain; Region: SelR; pfam01641 1138871009402 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1138871009403 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871009404 S-adenosylmethionine binding site [chemical binding]; other site 1138871009405 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 1138871009406 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1138871009407 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138871009408 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1138871009409 substrate binding site [chemical binding]; other site 1138871009410 active site 1138871009411 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138871009412 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138871009413 substrate binding site [chemical binding]; other site 1138871009414 oxyanion hole (OAH) forming residues; other site 1138871009415 trimer interface [polypeptide binding]; other site 1138871009416 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 1138871009417 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1138871009418 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1138871009419 catalytic site [active] 1138871009420 putative active site [active] 1138871009421 putative substrate binding site [chemical binding]; other site 1138871009422 Helicase and RNase D C-terminal; Region: HRDC; smart00341 1138871009423 Deoxyxylulose-5-phosphate synthase [Coenzyme metabolism / Lipid metabolism]; Region: Dxs; COG1154 1138871009424 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1138871009425 TPP-binding site; other site 1138871009426 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1138871009427 PYR/PP interface [polypeptide binding]; other site 1138871009428 dimer interface [polypeptide binding]; other site 1138871009429 TPP binding site [chemical binding]; other site 1138871009430 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1138871009431 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1138871009432 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1138871009433 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 1138871009434 transmembrane helices; other site 1138871009435 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1138871009436 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1138871009437 Walker A/P-loop; other site 1138871009438 ATP binding site [chemical binding]; other site 1138871009439 Q-loop/lid; other site 1138871009440 ABC transporter signature motif; other site 1138871009441 Walker B; other site 1138871009442 D-loop; other site 1138871009443 H-loop/switch region; other site 1138871009444 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1138871009445 putative DNA binding site [nucleotide binding]; other site 1138871009446 putative Zn2+ binding site [ion binding]; other site 1138871009447 TRAM domain; Region: TRAM; pfam01938 1138871009448 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1138871009449 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1138871009450 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1138871009451 TrkA-N domain; Region: TrkA_N; pfam02254 1138871009452 TrkA-C domain; Region: TrkA_C; pfam02080 1138871009453 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1138871009454 TrkA-N domain; Region: TrkA_N; pfam02254 1138871009455 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 1138871009456 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1138871009457 generic binding surface II; other site 1138871009458 ssDNA binding site; other site 1138871009459 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1138871009460 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1138871009461 trimer interface [polypeptide binding]; other site 1138871009462 active site 1138871009463 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 1138871009464 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1138871009465 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1138871009466 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1138871009467 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1138871009468 active site 1138871009469 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1138871009470 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1138871009471 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1138871009472 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138871009473 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1138871009474 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138871009475 DNA binding residues [nucleotide binding] 1138871009476 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 1138871009477 homotrimer interaction site [polypeptide binding]; other site 1138871009478 putative active site [active] 1138871009479 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1138871009480 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1138871009481 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 1138871009482 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1138871009483 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1138871009484 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138871009485 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1138871009486 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138871009487 DNA binding residues [nucleotide binding] 1138871009488 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1138871009489 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1138871009490 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1138871009491 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 1138871009492 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 1138871009493 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1138871009494 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138871009495 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138871009496 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1138871009497 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1138871009498 PAC2 family; Region: PAC2; pfam09754 1138871009499 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138871009500 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1138871009501 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 1138871009502 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 1138871009503 heme-binding site [chemical binding]; other site 1138871009504 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1138871009505 ATP cone domain; Region: ATP-cone; pfam03477 1138871009506 LexA repressor; Validated; Region: PRK00215 1138871009507 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1138871009508 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1138871009509 Catalytic site [active] 1138871009510 Uncharacterized protein potentially involved in peptidoglycan biosynthesis [Cell envelope biogenesis, outer membrane]; Region: COG5479 1138871009511 LGFP repeat; Region: LGFP; pfam08310 1138871009512 LGFP repeat; Region: LGFP; pfam08310 1138871009513 LGFP repeat; Region: LGFP; pfam08310 1138871009514 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871009515 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871009516 active site 1138871009517 GTPases [General function prediction only]; Region: HflX; COG2262 1138871009518 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1138871009519 HflX GTPase family; Region: HflX; cd01878 1138871009520 G1 box; other site 1138871009521 GTP/Mg2+ binding site [chemical binding]; other site 1138871009522 Switch I region; other site 1138871009523 G2 box; other site 1138871009524 G3 box; other site 1138871009525 Switch II region; other site 1138871009526 G4 box; other site 1138871009527 G5 box; other site 1138871009528 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1138871009529 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1138871009530 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1138871009531 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1138871009532 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1138871009533 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 1138871009534 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1138871009535 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1138871009536 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1138871009537 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1138871009538 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1138871009539 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1138871009540 FeS/SAM binding site; other site 1138871009541 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1138871009542 recombinase A; Provisional; Region: recA; PRK09354 1138871009543 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1138871009544 hexamer interface [polypeptide binding]; other site 1138871009545 Walker A motif; other site 1138871009546 ATP binding site [chemical binding]; other site 1138871009547 Walker B motif; other site 1138871009548 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 1138871009549 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1138871009550 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1138871009551 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1138871009552 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1138871009553 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1138871009554 Limonene-1,2-epoxide hydrolase catalytic domain; Region: LEH; pfam07858 1138871009555 PET ((Prickle Espinas Testin) domain is involved in protein-protein interactions; Region: PET; cl05674 1138871009556 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1138871009557 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1138871009558 non-specific DNA binding site [nucleotide binding]; other site 1138871009559 salt bridge; other site 1138871009560 sequence-specific DNA binding site [nucleotide binding]; other site 1138871009561 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1138871009562 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1138871009563 Coenzyme A binding pocket [chemical binding]; other site 1138871009564 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1138871009565 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1138871009566 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138871009567 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1138871009568 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1138871009569 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1138871009570 classical (c) SDRs; Region: SDR_c; cd05233 1138871009571 NAD(P) binding site [chemical binding]; other site 1138871009572 active site 1138871009573 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138871009574 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138871009575 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1138871009576 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1138871009577 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1138871009578 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1138871009579 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1138871009580 dimer interface [polypeptide binding]; other site 1138871009581 active site 1138871009582 catalytic residue [active] 1138871009583 FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847 1138871009584 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1138871009585 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1138871009586 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1138871009587 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1138871009588 folate binding site [chemical binding]; other site 1138871009589 NADP+ binding site [chemical binding]; other site 1138871009590 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1138871009591 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1138871009592 dimerization interface [polypeptide binding]; other site 1138871009593 active site 1138871009594 Dienelactone hydrolase family; Region: DLH; pfam01738 1138871009595 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871009596 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138871009597 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871009598 active site 1138871009599 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871009600 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871009601 active site 1138871009602 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1138871009603 classical (c) SDRs; Region: SDR_c; cd05233 1138871009604 NAD(P) binding site [chemical binding]; other site 1138871009605 active site 1138871009606 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1138871009607 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1138871009608 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1138871009609 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1138871009610 Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511 1138871009611 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1138871009612 carboxyltransferase (CT) interaction site; other site 1138871009613 biotinylation site [posttranslational modification]; other site 1138871009614 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1138871009615 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1138871009616 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1138871009617 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871009618 acyl-activating enzyme (AAE) consensus motif; other site 1138871009619 AMP binding site [chemical binding]; other site 1138871009620 active site 1138871009621 CoA binding site [chemical binding]; other site 1138871009622 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1138871009623 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1138871009624 CoenzymeA binding site [chemical binding]; other site 1138871009625 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1138871009626 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1138871009627 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1138871009628 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1138871009629 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1138871009630 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138871009631 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138871009632 active site 1138871009633 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138871009634 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1138871009635 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1138871009636 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1138871009637 iron-sulfur cluster [ion binding]; other site 1138871009638 [2Fe-2S] cluster binding site [ion binding]; other site 1138871009639 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1138871009640 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1138871009641 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1138871009642 FMN-binding pocket [chemical binding]; other site 1138871009643 flavin binding motif; other site 1138871009644 phosphate binding motif [ion binding]; other site 1138871009645 beta-alpha-beta structure motif; other site 1138871009646 NAD binding pocket [chemical binding]; other site 1138871009647 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1138871009648 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1138871009649 catalytic loop [active] 1138871009650 iron binding site [ion binding]; other site 1138871009651 short chain dehydrogenase; Validated; Region: PRK05855 1138871009652 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138871009653 classical (c) SDRs; Region: SDR_c; cd05233 1138871009654 NAD(P) binding site [chemical binding]; other site 1138871009655 active site 1138871009656 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1138871009657 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1138871009658 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138871009659 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138871009660 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1138871009661 hydrophobic ligand binding site; other site 1138871009662 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1138871009663 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1138871009664 hexamer interface [polypeptide binding]; other site 1138871009665 ligand binding site [chemical binding]; other site 1138871009666 putative active site [active] 1138871009667 NAD(P) binding site [chemical binding]; other site 1138871009668 Nitronate monooxygenase; Region: NMO; pfam03060 1138871009669 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1138871009670 FMN binding site [chemical binding]; other site 1138871009671 substrate binding site [chemical binding]; other site 1138871009672 putative catalytic residue [active] 1138871009673 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1138871009674 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1138871009675 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1138871009676 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1138871009677 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1138871009678 RNase E interface [polypeptide binding]; other site 1138871009679 trimer interface [polypeptide binding]; other site 1138871009680 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1138871009681 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1138871009682 RNase E interface [polypeptide binding]; other site 1138871009683 trimer interface [polypeptide binding]; other site 1138871009684 active site 1138871009685 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1138871009686 putative nucleic acid binding region [nucleotide binding]; other site 1138871009687 G-X-X-G motif; other site 1138871009688 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1138871009689 RNA binding site [nucleotide binding]; other site 1138871009690 domain interface; other site 1138871009691 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1138871009692 16S/18S rRNA binding site [nucleotide binding]; other site 1138871009693 S13e-L30e interaction site [polypeptide binding]; other site 1138871009694 25S rRNA binding site [nucleotide binding]; other site 1138871009695 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1138871009696 dimerization interface [polypeptide binding]; other site 1138871009697 putative DNA binding site [nucleotide binding]; other site 1138871009698 putative Zn2+ binding site [ion binding]; other site 1138871009699 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1138871009700 putative hydrophobic ligand binding site [chemical binding]; other site 1138871009701 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1138871009702 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1138871009703 active site 1138871009704 Riboflavin kinase; Region: Flavokinase; pfam01687 1138871009705 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1138871009706 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1138871009707 putative DNA binding site [nucleotide binding]; other site 1138871009708 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1138871009709 FeoA domain; Region: FeoA; pfam04023 1138871009710 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871009711 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871009712 active site 1138871009713 lipid-transfer protein; Provisional; Region: PRK08256 1138871009714 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138871009715 active site 1138871009716 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1138871009717 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1138871009718 RNA binding site [nucleotide binding]; other site 1138871009719 active site 1138871009720 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1138871009721 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1138871009722 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1138871009723 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1138871009724 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1138871009725 active site 1138871009726 metal binding site [ion binding]; metal-binding site 1138871009727 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1138871009728 active site 1138871009729 metal binding site [ion binding]; metal-binding site 1138871009730 Predicted acyl esterases [General function prediction only]; Region: COG2936 1138871009731 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1138871009732 Domain of unknown function (DUF1802); Region: DUF1802; pfam08819 1138871009733 Uncharacterized conserved protein (DUF2277); Region: DUF2277; cl02349 1138871009734 enoyl-CoA hydratase; Provisional; Region: PRK06190 1138871009735 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138871009736 substrate binding site [chemical binding]; other site 1138871009737 oxyanion hole (OAH) forming residues; other site 1138871009738 trimer interface [polypeptide binding]; other site 1138871009739 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1138871009740 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1138871009741 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1138871009742 DHH family; Region: DHH; pfam01368 1138871009743 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1138871009744 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1138871009745 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 1138871009746 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1138871009747 G1 box; other site 1138871009748 putative GEF interaction site [polypeptide binding]; other site 1138871009749 GTP/Mg2+ binding site [chemical binding]; other site 1138871009750 Switch I region; other site 1138871009751 G2 box; other site 1138871009752 G3 box; other site 1138871009753 Switch II region; other site 1138871009754 G4 box; other site 1138871009755 G5 box; other site 1138871009756 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1138871009757 Translation-initiation factor 2; Region: IF-2; pfam11987 1138871009758 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1138871009759 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 1138871009760 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1138871009761 NusA N-terminal domain; Region: NusA_N; pfam08529 1138871009762 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1138871009763 RNA binding site [nucleotide binding]; other site 1138871009764 homodimer interface [polypeptide binding]; other site 1138871009765 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1138871009766 G-X-X-G motif; other site 1138871009767 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1138871009768 G-X-X-G motif; other site 1138871009769 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1138871009770 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1138871009771 putative oligomer interface [polypeptide binding]; other site 1138871009772 putative RNA binding site [nucleotide binding]; other site 1138871009773 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1138871009774 dinuclear metal binding motif [ion binding]; other site 1138871009775 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1138871009776 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1138871009777 motif 1; other site 1138871009778 dimer interface [polypeptide binding]; other site 1138871009779 active site 1138871009780 motif 2; other site 1138871009781 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1138871009782 putative deacylase active site [active] 1138871009783 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1138871009784 active site 1138871009785 motif 3; other site 1138871009786 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1138871009787 anticodon binding site; other site 1138871009788 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138871009789 putative substrate translocation pore; other site 1138871009790 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1138871009791 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1138871009792 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1138871009793 active site 1138871009794 SAM binding site [chemical binding]; other site 1138871009795 homodimer interface [polypeptide binding]; other site 1138871009796 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1138871009797 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1138871009798 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1138871009799 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1138871009800 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1138871009801 Walker A motif; other site 1138871009802 homodimer interface [polypeptide binding]; other site 1138871009803 ATP binding site [chemical binding]; other site 1138871009804 hydroxycobalamin binding site [chemical binding]; other site 1138871009805 Walker B motif; other site 1138871009806 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 1138871009807 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1138871009808 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 1138871009809 metal ion-dependent adhesion site (MIDAS); other site 1138871009810 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1138871009811 Coenzyme A binding pocket [chemical binding]; other site 1138871009812 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1138871009813 malate:quinone oxidoreductase; Validated; Region: PRK05257 1138871009814 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1138871009815 mycothione reductase; Reviewed; Region: PRK07846 1138871009816 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138871009817 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138871009818 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1138871009819 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1138871009820 metal binding site 2 [ion binding]; metal-binding site 1138871009821 putative DNA binding helix; other site 1138871009822 metal binding site 1 [ion binding]; metal-binding site 1138871009823 dimer interface [polypeptide binding]; other site 1138871009824 structural Zn2+ binding site [ion binding]; other site 1138871009825 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 1138871009826 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 1138871009827 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 1138871009828 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1138871009829 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1138871009830 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1138871009831 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374 1138871009832 NifU-like domain; Region: NifU; cl00484 1138871009833 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1138871009834 iron-sulfur cluster [ion binding]; other site 1138871009835 [2Fe-2S] cluster binding site [ion binding]; other site 1138871009836 Putative [NiFe] hydrogenase-specific C-terminal protease. Sequence comparison shows similarity to hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). Maturation of [FeNi] hydrogenases includes formation of...; Region: H2MP_like-1; cd06068 1138871009837 nickel binding site [ion binding]; other site 1138871009838 HupF/HypC family; Region: HupF_HypC; pfam01455 1138871009839 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 1138871009840 Acylphosphatase; Region: Acylphosphatase; pfam00708 1138871009841 HypF finger; Region: zf-HYPF; pfam07503 1138871009842 HypF finger; Region: zf-HYPF; pfam07503 1138871009843 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 1138871009844 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1138871009845 HupF/HypC family; Region: HupF_HypC; pfam01455 1138871009846 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1138871009847 active site 1138871009848 dimer interface [polypeptide binding]; other site 1138871009849 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 1138871009850 dimerization interface [polypeptide binding]; other site 1138871009851 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 1138871009852 ATP binding site [chemical binding]; other site 1138871009853 HupF/HypC family; Region: HupF_HypC; pfam01455 1138871009854 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 1138871009855 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 1138871009856 Uncharacterized conserved protein [Function unknown]; Region: COG3379 1138871009857 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1138871009858 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871009859 PPE family; Region: PPE; pfam00823 1138871009860 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 1138871009861 classical (c) SDRs; Region: SDR_c; cd05233 1138871009862 NAD(P) binding site [chemical binding]; other site 1138871009863 active site 1138871009864 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138871009865 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1138871009866 NAD(P) binding site [chemical binding]; other site 1138871009867 catalytic residues [active] 1138871009868 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1138871009869 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1138871009870 catalytic triad [active] 1138871009871 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1138871009872 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1138871009873 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1138871009874 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138871009875 cobyric acid synthase; Provisional; Region: PRK00784 1138871009876 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1138871009877 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1138871009878 catalytic triad [active] 1138871009879 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1138871009880 active site 1138871009881 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 1138871009882 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 1138871009883 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1138871009884 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1138871009885 Predicted acetyltransferase [General function prediction only]; Region: COG3393 1138871009886 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 1138871009887 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1138871009888 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1138871009889 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1138871009890 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 1138871009891 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1138871009892 active site 1138871009893 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1138871009894 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1138871009895 putative substrate binding region [chemical binding]; other site 1138871009896 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1138871009897 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1138871009898 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1138871009899 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1138871009900 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1138871009901 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1138871009902 FeS/SAM binding site; other site 1138871009903 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1138871009904 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1138871009905 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1138871009906 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1138871009907 hinge region; other site 1138871009908 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1138871009909 putative nucleotide binding site [chemical binding]; other site 1138871009910 uridine monophosphate binding site [chemical binding]; other site 1138871009911 homohexameric interface [polypeptide binding]; other site 1138871009912 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1138871009913 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1138871009914 DNA binding site [nucleotide binding] 1138871009915 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1138871009916 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1138871009917 putative acyl-acceptor binding pocket; other site 1138871009918 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 1138871009919 short chain dehydrogenase; Provisional; Region: PRK06701 1138871009920 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871009921 NAD(P) binding site [chemical binding]; other site 1138871009922 active site 1138871009923 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 1138871009924 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1138871009925 Moco binding site; other site 1138871009926 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1138871009927 metal coordination site [ion binding]; other site 1138871009928 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666 1138871009929 ChaB; Region: ChaB; pfam06150 1138871009930 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 1138871009931 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1138871009932 MarR family; Region: MarR; pfam01047 1138871009933 amidase; Provisional; Region: PRK07869 1138871009934 Amidase; Region: Amidase; pfam01425 1138871009935 elongation factor Ts; Provisional; Region: tsf; PRK09377 1138871009936 UBA/TS-N domain; Region: UBA; pfam00627 1138871009937 Elongation factor TS; Region: EF_TS; pfam00889 1138871009938 Elongation factor TS; Region: EF_TS; pfam00889 1138871009939 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1138871009940 rRNA interaction site [nucleotide binding]; other site 1138871009941 S8 interaction site; other site 1138871009942 putative laminin-1 binding site; other site 1138871009943 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1138871009944 Peptidase family M23; Region: Peptidase_M23; pfam01551 1138871009945 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1138871009946 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1138871009947 active site 1138871009948 DNA binding site [nucleotide binding] 1138871009949 Int/Topo IB signature motif; other site 1138871009950 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 1138871009951 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 1138871009952 putative active site [active] 1138871009953 putative substrate binding site [chemical binding]; other site 1138871009954 putative FMN binding site [chemical binding]; other site 1138871009955 putative catalytic residues [active] 1138871009956 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1138871009957 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1138871009958 FAD binding pocket [chemical binding]; other site 1138871009959 FAD binding motif [chemical binding]; other site 1138871009960 phosphate binding motif [ion binding]; other site 1138871009961 NAD binding pocket [chemical binding]; other site 1138871009962 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871009963 PPE family; Region: PPE; pfam00823 1138871009964 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1138871009965 DNA protecting protein DprA; Region: dprA; TIGR00732 1138871009966 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 1138871009967 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1138871009968 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1138871009969 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1138871009970 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138871009971 Walker A motif; other site 1138871009972 ATP binding site [chemical binding]; other site 1138871009973 Walker B motif; other site 1138871009974 arginine finger; other site 1138871009975 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1138871009976 hypothetical protein; Reviewed; Region: PRK12497 1138871009977 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1138871009978 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1138871009979 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1138871009980 putative molybdopterin cofactor binding site [chemical binding]; other site 1138871009981 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1138871009982 putative molybdopterin cofactor binding site; other site 1138871009983 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871009984 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1138871009985 NAD(P) binding site [chemical binding]; other site 1138871009986 active site 1138871009987 ANTAR domain; Region: ANTAR; pfam03861 1138871009988 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1138871009989 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1138871009990 RNA/DNA hybrid binding site [nucleotide binding]; other site 1138871009991 active site 1138871009992 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1138871009993 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1138871009994 Catalytic site [active] 1138871009995 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1138871009996 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1138871009997 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1138871009998 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1138871009999 RimM N-terminal domain; Region: RimM; pfam01782 1138871010000 PRC-barrel domain; Region: PRC; pfam05239 1138871010001 hypothetical protein; Provisional; Region: PRK02821 1138871010002 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1138871010003 G-X-X-G motif; other site 1138871010004 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1138871010005 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1138871010006 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1138871010007 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1138871010008 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871010009 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871010010 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1138871010011 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138871010012 active site 1138871010013 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138871010014 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1138871010015 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138871010016 active site 1138871010017 signal recognition particle protein; Provisional; Region: PRK10867 1138871010018 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1138871010019 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1138871010020 P loop; other site 1138871010021 GTP binding site [chemical binding]; other site 1138871010022 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1138871010023 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138871010024 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1138871010025 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1138871010026 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1138871010027 ATP binding site [chemical binding]; other site 1138871010028 putative Mg++ binding site [ion binding]; other site 1138871010029 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138871010030 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1138871010031 active site 1138871010032 PII uridylyl-transferase; Provisional; Region: PRK03381 1138871010033 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1138871010034 metal binding triad; other site 1138871010035 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1138871010036 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1138871010037 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 1138871010038 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 1138871010039 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1138871010040 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1138871010041 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1138871010042 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1138871010043 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1138871010044 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1138871010045 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1138871010046 AAA domain; Region: AAA_23; pfam13476 1138871010047 Walker A/P-loop; other site 1138871010048 ATP binding site [chemical binding]; other site 1138871010049 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1138871010050 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1138871010051 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1138871010052 ABC transporter signature motif; other site 1138871010053 Walker B; other site 1138871010054 D-loop; other site 1138871010055 H-loop/switch region; other site 1138871010056 acylphosphatase; Provisional; Region: PRK14422 1138871010057 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1138871010058 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1138871010059 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1138871010060 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1138871010061 DNA binding site [nucleotide binding] 1138871010062 catalytic residue [active] 1138871010063 H2TH interface [polypeptide binding]; other site 1138871010064 putative catalytic residues [active] 1138871010065 turnover-facilitating residue; other site 1138871010066 intercalation triad [nucleotide binding]; other site 1138871010067 8OG recognition residue [nucleotide binding]; other site 1138871010068 putative reading head residues; other site 1138871010069 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1138871010070 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1138871010071 ribonuclease III; Reviewed; Region: rnc; PRK00102 1138871010072 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1138871010073 dimerization interface [polypeptide binding]; other site 1138871010074 active site 1138871010075 metal binding site [ion binding]; metal-binding site 1138871010076 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1138871010077 dsRNA binding site [nucleotide binding]; other site 1138871010078 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1138871010079 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 1138871010080 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1138871010081 Predicted permease; Region: DUF318; pfam03773 1138871010082 acetolactate synthase catalytic subunit; Validated; Region: PRK08327 1138871010083 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1138871010084 PYR/PP interface [polypeptide binding]; other site 1138871010085 dimer interface [polypeptide binding]; other site 1138871010086 TPP binding site [chemical binding]; other site 1138871010087 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1138871010088 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 1138871010089 TPP-binding site [chemical binding]; other site 1138871010090 dimer interface [polypeptide binding]; other site 1138871010091 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138871010092 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138871010093 active site 1138871010094 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1138871010095 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1138871010096 active site 1138871010097 (T/H)XGH motif; other site 1138871010098 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1138871010099 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871010100 S-adenosylmethionine binding site [chemical binding]; other site 1138871010101 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 1138871010102 putative active site [active] 1138871010103 redox center [active] 1138871010104 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1138871010105 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1138871010106 catalytic residues [active] 1138871010107 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1138871010108 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138871010109 substrate binding pocket [chemical binding]; other site 1138871010110 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1138871010111 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1138871010112 active site 1138871010113 catalytic tetrad [active] 1138871010114 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1138871010115 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1138871010116 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1138871010117 ssDNA binding site; other site 1138871010118 generic binding surface II; other site 1138871010119 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1138871010120 ATP binding site [chemical binding]; other site 1138871010121 putative Mg++ binding site [ion binding]; other site 1138871010122 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1138871010123 nucleotide binding region [chemical binding]; other site 1138871010124 ATP-binding site [chemical binding]; other site 1138871010125 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1138871010126 DAK2 domain; Region: Dak2; cl03685 1138871010127 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1138871010128 catalytic residue [active] 1138871010129 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1138871010130 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1138871010131 classical (c) SDRs; Region: SDR_c; cd05233 1138871010132 NAD(P) binding site [chemical binding]; other site 1138871010133 active site 1138871010134 short chain dehydrogenase; Provisional; Region: PRK06197 1138871010135 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871010136 NAD(P) binding site [chemical binding]; other site 1138871010137 active site 1138871010138 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1138871010139 short chain dehydrogenase; Provisional; Region: PRK06180 1138871010140 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1138871010141 NADP binding site [chemical binding]; other site 1138871010142 active site 1138871010143 steroid binding site; other site 1138871010144 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1138871010145 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1138871010146 putative NAD(P) binding site [chemical binding]; other site 1138871010147 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1138871010148 ligand binding site [chemical binding]; other site 1138871010149 active site 1138871010150 UGI interface [polypeptide binding]; other site 1138871010151 catalytic site [active] 1138871010152 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 1138871010153 thiamine monophosphate kinase; Provisional; Region: PRK05731 1138871010154 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1138871010155 ATP binding site [chemical binding]; other site 1138871010156 dimerization interface [polypeptide binding]; other site 1138871010157 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 1138871010158 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1138871010159 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1138871010160 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1138871010161 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1138871010162 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1138871010163 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1138871010164 2-phospho-L-lactate guanylyltransferase; Region: F420_cofC; TIGR03552 1138871010165 polyphosphate kinase; Provisional; Region: PRK05443 1138871010166 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1138871010167 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1138871010168 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1138871010169 putative domain interface [polypeptide binding]; other site 1138871010170 putative active site [active] 1138871010171 catalytic site [active] 1138871010172 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1138871010173 putative domain interface [polypeptide binding]; other site 1138871010174 putative active site [active] 1138871010175 catalytic site [active] 1138871010176 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1138871010177 active site 1138871010178 Ap6A binding site [chemical binding]; other site 1138871010179 nudix motif; other site 1138871010180 metal binding site [ion binding]; metal-binding site 1138871010181 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1138871010182 catalytic core [active] 1138871010183 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1138871010184 IHF - DNA interface [nucleotide binding]; other site 1138871010185 IHF dimer interface [polypeptide binding]; other site 1138871010186 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1138871010187 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1138871010188 substrate binding site [chemical binding]; other site 1138871010189 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1138871010190 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1138871010191 substrate binding site [chemical binding]; other site 1138871010192 ligand binding site [chemical binding]; other site 1138871010193 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1138871010194 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1138871010195 Bacterial transcriptional regulator; Region: IclR; pfam01614 1138871010196 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1138871010197 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1138871010198 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1138871010199 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1138871010200 active site 1138871010201 KMSKS motif; other site 1138871010202 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1138871010203 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1138871010204 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1138871010205 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138871010206 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1138871010207 putative substrate translocation pore; other site 1138871010208 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138871010209 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1138871010210 putative substrate translocation pore; other site 1138871010211 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 1138871010212 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1138871010213 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1138871010214 ligand binding site [chemical binding]; other site 1138871010215 NAD binding site [chemical binding]; other site 1138871010216 dimerization interface [polypeptide binding]; other site 1138871010217 catalytic site [active] 1138871010218 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1138871010219 putative L-serine binding site [chemical binding]; other site 1138871010220 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1138871010221 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138871010222 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1138871010223 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1138871010224 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1138871010225 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1138871010226 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1138871010227 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1138871010228 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1138871010229 putative valine binding site [chemical binding]; other site 1138871010230 dimer interface [polypeptide binding]; other site 1138871010231 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1138871010232 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 1138871010233 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1138871010234 PYR/PP interface [polypeptide binding]; other site 1138871010235 dimer interface [polypeptide binding]; other site 1138871010236 TPP binding site [chemical binding]; other site 1138871010237 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1138871010238 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1138871010239 TPP-binding site [chemical binding]; other site 1138871010240 dimer interface [polypeptide binding]; other site 1138871010241 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 1138871010242 Predicted membrane protein [Function unknown]; Region: COG2259 1138871010243 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 1138871010244 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1138871010245 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1138871010246 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1138871010247 GatB domain; Region: GatB_Yqey; smart00845 1138871010248 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1138871010249 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1138871010250 P-loop; other site 1138871010251 Magnesium ion binding site [ion binding]; other site 1138871010252 6-phosphofructokinase; Provisional; Region: PRK03202 1138871010253 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1138871010254 active site 1138871010255 ADP/pyrophosphate binding site [chemical binding]; other site 1138871010256 dimerization interface [polypeptide binding]; other site 1138871010257 allosteric effector site; other site 1138871010258 fructose-1,6-bisphosphate binding site; other site 1138871010259 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1138871010260 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1138871010261 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1138871010262 ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887 1138871010263 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1138871010264 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1138871010265 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1138871010266 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871010267 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871010268 cystathionine gamma-lyase; Validated; Region: PRK07582 1138871010269 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1138871010270 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138871010271 catalytic residue [active] 1138871010272 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1138871010273 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1138871010274 nucleotide binding pocket [chemical binding]; other site 1138871010275 K-X-D-G motif; other site 1138871010276 catalytic site [active] 1138871010277 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1138871010278 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1138871010279 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1138871010280 Dimer interface [polypeptide binding]; other site 1138871010281 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1138871010282 putative DNA binding site [nucleotide binding]; other site 1138871010283 putative Zn2+ binding site [ion binding]; other site 1138871010284 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898 1138871010285 putative hydrophobic ligand binding site [chemical binding]; other site 1138871010286 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 1138871010287 PknH-like extracellular domain; Region: PknH_C; pfam14032 1138871010288 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1138871010289 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1138871010290 Ligand Binding Site [chemical binding]; other site 1138871010291 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1138871010292 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1138871010293 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1138871010294 catalytic residue [active] 1138871010295 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1138871010296 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1138871010297 putative acyl-acceptor binding pocket; other site 1138871010298 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 1138871010299 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1138871010300 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1138871010301 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1138871010302 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1138871010303 Ligand binding site [chemical binding]; other site 1138871010304 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1138871010305 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1138871010306 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871010307 S-adenosylmethionine binding site [chemical binding]; other site 1138871010308 Uncharacterized conserved protein [Function unknown]; Region: COG1543 1138871010309 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1138871010310 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 1138871010311 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1138871010312 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1138871010313 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 1138871010314 putative hydrophobic ligand binding site [chemical binding]; other site 1138871010315 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871010316 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1138871010317 NAD(P) binding site [chemical binding]; other site 1138871010318 active site 1138871010319 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1138871010320 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871010321 NAD(P) binding site [chemical binding]; other site 1138871010322 active site 1138871010323 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1138871010324 anti sigma factor interaction site; other site 1138871010325 regulatory phosphorylation site [posttranslational modification]; other site 1138871010326 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1138871010327 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1138871010328 substrate binding pocket [chemical binding]; other site 1138871010329 chain length determination region; other site 1138871010330 substrate-Mg2+ binding site; other site 1138871010331 catalytic residues [active] 1138871010332 aspartate-rich region 1; other site 1138871010333 active site lid residues [active] 1138871010334 aspartate-rich region 2; other site 1138871010335 phytoene desaturase; Region: crtI_fam; TIGR02734 1138871010336 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1138871010337 active site lid residues [active] 1138871010338 substrate binding pocket [chemical binding]; other site 1138871010339 catalytic residues [active] 1138871010340 substrate-Mg2+ binding site; other site 1138871010341 aspartate-rich region 1; other site 1138871010342 aspartate-rich region 2; other site 1138871010343 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 1138871010344 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 1138871010345 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871010346 S-adenosylmethionine binding site [chemical binding]; other site 1138871010347 Uncharacterized conserved protein [Function unknown]; Region: COG3349 1138871010348 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138871010349 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1138871010350 [2Fe-2S] cluster binding site [ion binding]; other site 1138871010351 iron-sulfur cluster [ion binding]; other site 1138871010352 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 1138871010353 MarR family; Region: MarR_2; pfam12802 1138871010354 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1138871010355 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1138871010356 homotetramer interface [polypeptide binding]; other site 1138871010357 FMN binding site [chemical binding]; other site 1138871010358 homodimer contacts [polypeptide binding]; other site 1138871010359 putative active site [active] 1138871010360 putative substrate binding site [chemical binding]; other site 1138871010361 MMPL family; Region: MMPL; pfam03176 1138871010362 TspO/MBR family; Region: TspO_MBR; pfam03073 1138871010363 DNA photolyase; Region: DNA_photolyase; pfam00875 1138871010364 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1138871010365 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1138871010366 Domain of unknown function (DUF4333); Region: DUF4333; pfam14230 1138871010367 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1138871010368 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1138871010369 trimer interface [polypeptide binding]; other site 1138871010370 active site 1138871010371 substrate binding site [chemical binding]; other site 1138871010372 CoA binding site [chemical binding]; other site 1138871010373 FOG: WD40-like repeat [Function unknown]; Region: COG1520 1138871010374 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1138871010375 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1138871010376 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871010377 S-adenosylmethionine binding site [chemical binding]; other site 1138871010378 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138871010379 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138871010380 substrate binding site [chemical binding]; other site 1138871010381 oxyanion hole (OAH) forming residues; other site 1138871010382 trimer interface [polypeptide binding]; other site 1138871010383 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1138871010384 nudix motif; other site 1138871010385 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 1138871010386 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138871010387 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138871010388 Walker A/P-loop; other site 1138871010389 Walker A/P-loop; other site 1138871010390 ATP binding site [chemical binding]; other site 1138871010391 ATP binding site [chemical binding]; other site 1138871010392 Q-loop/lid; other site 1138871010393 ABC transporter signature motif; other site 1138871010394 Walker B; other site 1138871010395 D-loop; other site 1138871010396 H-loop/switch region; other site 1138871010397 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 1138871010398 ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871 1138871010399 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1138871010400 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138871010401 motif II; other site 1138871010402 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1138871010403 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1138871010404 D-pathway; other site 1138871010405 Putative ubiquinol binding site [chemical binding]; other site 1138871010406 Low-spin heme (heme b) binding site [chemical binding]; other site 1138871010407 Putative water exit pathway; other site 1138871010408 Binuclear center (heme o3/CuB) [ion binding]; other site 1138871010409 K-pathway; other site 1138871010410 Putative proton exit pathway; other site 1138871010411 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1138871010412 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1138871010413 siderophore binding site; other site 1138871010414 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1138871010415 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1138871010416 putative NAD(P) binding site [chemical binding]; other site 1138871010417 putative substrate binding site [chemical binding]; other site 1138871010418 catalytic Zn binding site [ion binding]; other site 1138871010419 structural Zn binding site [ion binding]; other site 1138871010420 dimer interface [polypeptide binding]; other site 1138871010421 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1138871010422 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1138871010423 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1138871010424 dimer interface [polypeptide binding]; other site 1138871010425 putative radical transfer pathway; other site 1138871010426 diiron center [ion binding]; other site 1138871010427 tyrosyl radical; other site 1138871010428 Ligand-binding SRPBCC domain of Streptococcus mutans Smu.440 and related proteins; Region: SRPBCC_Smu440-like; cd08862 1138871010429 putative hydrophobic ligand binding site [chemical binding]; other site 1138871010430 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871010431 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871010432 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1138871010433 Ligand Binding Site [chemical binding]; other site 1138871010434 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138871010435 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138871010436 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871010437 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871010438 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1138871010439 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1138871010440 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1138871010441 active site 1138871010442 dimer interface [polypeptide binding]; other site 1138871010443 catalytic residues [active] 1138871010444 effector binding site; other site 1138871010445 R2 peptide binding site; other site 1138871010446 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1138871010447 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1138871010448 catalytic residues [active] 1138871010449 Predicted flavoprotein [General function prediction only]; Region: COG0431 1138871010450 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1138871010451 DNA polymerase IV; Validated; Region: PRK03352 1138871010452 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1138871010453 active site 1138871010454 DNA binding site [nucleotide binding] 1138871010455 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871010456 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871010457 Cytochrome P450; Region: p450; cl12078 1138871010458 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871010459 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1138871010460 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 1138871010461 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1138871010462 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1138871010463 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138871010464 DNA-binding site [nucleotide binding]; DNA binding site 1138871010465 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1138871010466 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1138871010467 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1138871010468 DNA-binding site [nucleotide binding]; DNA binding site 1138871010469 FCD domain; Region: FCD; pfam07729 1138871010470 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138871010471 active site 1138871010472 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138871010473 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871010474 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871010475 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871010476 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871010477 active site 1138871010478 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 1138871010479 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871010480 NAD(P) binding site [chemical binding]; other site 1138871010481 active site 1138871010482 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 1138871010483 active site 1138871010484 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 1138871010485 DNA binding site [nucleotide binding] 1138871010486 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 1138871010487 DNA binding site [nucleotide binding] 1138871010488 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1138871010489 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 1138871010490 nucleotide binding site [chemical binding]; other site 1138871010491 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1138871010492 SBD interface [polypeptide binding]; other site 1138871010493 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1138871010494 FMN binding site [chemical binding]; other site 1138871010495 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1138871010496 dimer interface [polypeptide binding]; other site 1138871010497 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138871010498 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 1138871010499 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138871010500 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 1138871010501 dimer interface [polypeptide binding]; other site 1138871010502 active site 1138871010503 enoyl-CoA hydratase; Provisional; Region: PRK05864 1138871010504 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138871010505 substrate binding site [chemical binding]; other site 1138871010506 oxyanion hole (OAH) forming residues; other site 1138871010507 trimer interface [polypeptide binding]; other site 1138871010508 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138871010509 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138871010510 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871010511 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871010512 active site 1138871010513 MspA; Region: MspA; pfam09203 1138871010514 Phosphotransferase enzyme family; Region: APH; pfam01636 1138871010515 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1138871010516 putative active site [active] 1138871010517 putative substrate binding site [chemical binding]; other site 1138871010518 ATP binding site [chemical binding]; other site 1138871010519 short chain dehydrogenase; Provisional; Region: PRK08278 1138871010520 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871010521 NAD(P) binding site [chemical binding]; other site 1138871010522 active site 1138871010523 Predicted membrane protein [Function unknown]; Region: COG2259 1138871010524 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138871010525 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1138871010526 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1138871010527 Transport protein; Region: actII; TIGR00833 1138871010528 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1138871010529 classical (c) SDRs; Region: SDR_c; cd05233 1138871010530 NAD(P) binding site [chemical binding]; other site 1138871010531 active site 1138871010532 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1138871010533 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1138871010534 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1138871010535 substrate binding pocket [chemical binding]; other site 1138871010536 active site 1138871010537 iron coordination sites [ion binding]; other site 1138871010538 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1138871010539 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1138871010540 [2Fe-2S] cluster binding site [ion binding]; other site 1138871010541 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 1138871010542 alpha subunit interface [polypeptide binding]; other site 1138871010543 active site 1138871010544 substrate binding site [chemical binding]; other site 1138871010545 Fe binding site [ion binding]; other site 1138871010546 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138871010547 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871010548 NAD(P) binding site [chemical binding]; other site 1138871010549 active site 1138871010550 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1138871010551 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1138871010552 FAD binding pocket [chemical binding]; other site 1138871010553 FAD binding motif [chemical binding]; other site 1138871010554 phosphate binding motif [ion binding]; other site 1138871010555 beta-alpha-beta structure motif; other site 1138871010556 NAD(p) ribose binding residues [chemical binding]; other site 1138871010557 NAD binding pocket [chemical binding]; other site 1138871010558 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1138871010559 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1138871010560 catalytic loop [active] 1138871010561 iron binding site [ion binding]; other site 1138871010562 MarR family; Region: MarR_2; pfam12802 1138871010563 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138871010564 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1138871010565 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1138871010566 active site 1138871010567 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1138871010568 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1138871010569 [2Fe-2S] cluster binding site [ion binding]; other site 1138871010570 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 1138871010571 alpha subunit interface [polypeptide binding]; other site 1138871010572 active site 1138871010573 substrate binding site [chemical binding]; other site 1138871010574 Fe binding site [ion binding]; other site 1138871010575 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138871010576 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 1138871010577 NAD binding site [chemical binding]; other site 1138871010578 catalytic residues [active] 1138871010579 Fic/DOC family; Region: Fic; cl00960 1138871010580 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138871010581 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1138871010582 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138871010583 phosphoglucomutase; Validated; Region: PRK07564 1138871010584 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1138871010585 active site 1138871010586 substrate binding site [chemical binding]; other site 1138871010587 metal binding site [ion binding]; metal-binding site 1138871010588 camphor resistance protein CrcB; Provisional; Region: PRK14216 1138871010589 camphor resistance protein CrcB; Provisional; Region: PRK14228 1138871010590 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1138871010591 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1138871010592 Protein of unknown function, DUF488; Region: DUF488; cl01246 1138871010593 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138871010594 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138871010595 active site 1138871010596 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1138871010597 Hemerythrin-like domain; Region: Hr-like; cd12108 1138871010598 Fe binding site [ion binding]; other site 1138871010599 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1138871010600 hypothetical protein; Validated; Region: PRK00029 1138871010601 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1138871010602 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138871010603 Domain of unknown function (DUF4267); Region: DUF4267; pfam14087 1138871010604 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871010605 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1138871010606 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138871010607 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 1138871010608 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 1138871010609 putative active site [active] 1138871010610 catalytic site [active] 1138871010611 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 1138871010612 putative active site [active] 1138871010613 catalytic site [active] 1138871010614 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 1138871010615 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1138871010616 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138871010617 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1138871010618 ADP-ribosyl cyclase, also known as cyclic ADP-ribose hydrolase or CD38; Region: Rib_hydrolase; cl08346 1138871010619 NAD binding site [chemical binding]; other site 1138871010620 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1138871010621 dimerization interface [polypeptide binding]; other site 1138871010622 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1138871010623 cyclase homology domain; Region: CHD; cd07302 1138871010624 nucleotidyl binding site; other site 1138871010625 metal binding site [ion binding]; metal-binding site 1138871010626 dimer interface [polypeptide binding]; other site 1138871010627 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138871010628 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1138871010629 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1138871010630 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1138871010631 Taurine catabolism dioxygenase TauD, TfdA family; Region: TauD; pfam02668 1138871010632 active site 1138871010633 iron coordination sites [ion binding]; other site 1138871010634 substrate binding pocket [chemical binding]; other site 1138871010635 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1138871010636 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1138871010637 [2Fe-2S] cluster binding site [ion binding]; other site 1138871010638 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 1138871010639 alpha subunit interface [polypeptide binding]; other site 1138871010640 active site 1138871010641 substrate binding site [chemical binding]; other site 1138871010642 Fe binding site [ion binding]; other site 1138871010643 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1138871010644 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1138871010645 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1138871010646 putative effector binding pocket; other site 1138871010647 dimerization interface [polypeptide binding]; other site 1138871010648 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1138871010649 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138871010650 phosphopeptide binding site; other site 1138871010651 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1138871010652 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138871010653 phosphopeptide binding site; other site 1138871010654 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1138871010655 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1138871010656 Walker A/P-loop; other site 1138871010657 ATP binding site [chemical binding]; other site 1138871010658 Q-loop/lid; other site 1138871010659 ABC transporter signature motif; other site 1138871010660 Walker B; other site 1138871010661 D-loop; other site 1138871010662 H-loop/switch region; other site 1138871010663 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1138871010664 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1138871010665 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1138871010666 active site 1138871010667 ATP binding site [chemical binding]; other site 1138871010668 substrate binding site [chemical binding]; other site 1138871010669 activation loop (A-loop); other site 1138871010670 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1138871010671 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1138871010672 Kelch domain; Region: Kelch; smart00612 1138871010673 Kelch motif; Region: Kelch_1; pfam01344 1138871010674 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1138871010675 Kelch motif; Region: Kelch_1; pfam01344 1138871010676 Kelch domain; Region: Kelch; smart00612 1138871010677 Kelch motif; Region: Kelch_6; pfam13964 1138871010678 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1138871010679 Kelch motif; Region: Kelch_1; pfam01344 1138871010680 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1138871010681 Domain of unknown function (DUF385); Region: DUF385; pfam04075 1138871010682 Domain of unknown function (DUF1942); Region: DUF1942; pfam09167 1138871010683 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1138871010684 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1138871010685 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1138871010686 SmpB-tmRNA interface; other site 1138871010687 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1138871010688 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1138871010689 FtsX-like permease family; Region: FtsX; pfam02687 1138871010690 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1138871010691 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138871010692 Walker A/P-loop; other site 1138871010693 ATP binding site [chemical binding]; other site 1138871010694 Q-loop/lid; other site 1138871010695 ABC transporter signature motif; other site 1138871010696 Walker B; other site 1138871010697 D-loop; other site 1138871010698 H-loop/switch region; other site 1138871010699 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1138871010700 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1138871010701 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1138871010702 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1138871010703 RF-1 domain; Region: RF-1; pfam00472 1138871010704 NADPH-dependent glutamate synthase beta chain and related oxidoreductases [Amino acid transport and metabolism / General function prediction only]; Region: GltD; COG0493 1138871010705 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1138871010706 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1138871010707 heme-binding site [chemical binding]; other site 1138871010708 hypothetical protein; Provisional; Region: PRK07877 1138871010709 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1138871010710 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1138871010711 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1138871010712 Histidine kinase; Region: HisKA_3; pfam07730 1138871010713 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1138871010714 ATP binding site [chemical binding]; other site 1138871010715 G-X-G motif; other site 1138871010716 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1138871010717 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138871010718 active site 1138871010719 phosphorylation site [posttranslational modification] 1138871010720 intermolecular recognition site; other site 1138871010721 dimerization interface [polypeptide binding]; other site 1138871010722 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1138871010723 DNA binding residues [nucleotide binding] 1138871010724 dimerization interface [polypeptide binding]; other site 1138871010725 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1138871010726 Ligand Binding Site [chemical binding]; other site 1138871010727 Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256 1138871010728 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 1138871010729 Binuclear center (active site) [active] 1138871010730 K-pathway; other site 1138871010731 Putative proton exit pathway; other site 1138871010732 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1138871010733 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1138871010734 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1138871010735 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871010736 PPE family; Region: PPE; pfam00823 1138871010737 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138871010738 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871010739 PPE family; Region: PPE; pfam00823 1138871010740 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138871010741 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1138871010742 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1138871010743 active site 1138871010744 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871010745 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871010746 active site 1138871010747 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871010748 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871010749 active site 1138871010750 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1138871010751 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1138871010752 NADP binding site [chemical binding]; other site 1138871010753 dimer interface [polypeptide binding]; other site 1138871010754 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1138871010755 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1138871010756 NAD(P) binding site [chemical binding]; other site 1138871010757 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 1138871010758 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138871010759 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1138871010760 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138871010761 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138871010762 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1138871010763 active site 1138871010764 catalytic residues [active] 1138871010765 metal binding site [ion binding]; metal-binding site 1138871010766 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871010767 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871010768 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871010769 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138871010770 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1138871010771 active site 1138871010772 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1138871010773 Phosphotransferase enzyme family; Region: APH; pfam01636 1138871010774 putative active site [active] 1138871010775 putative substrate binding site [chemical binding]; other site 1138871010776 ATP binding site [chemical binding]; other site 1138871010777 SnoaL-like domain; Region: SnoaL_2; pfam12680 1138871010778 YceI-like domain; Region: YceI; pfam04264 1138871010779 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1138871010780 active site 1138871010781 phosphorylation site [posttranslational modification] 1138871010782 intermolecular recognition site; other site 1138871010783 dimerization interface [polypeptide binding]; other site 1138871010784 NADH dehydrogenase subunit A; Validated; Region: PRK07928 1138871010785 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1138871010786 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 1138871010787 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1138871010788 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 1138871010789 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1138871010790 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1138871010791 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1138871010792 putative dimer interface [polypeptide binding]; other site 1138871010793 [2Fe-2S] cluster binding site [ion binding]; other site 1138871010794 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 1138871010795 SLBB domain; Region: SLBB; pfam10531 1138871010796 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1138871010797 NADH dehydrogenase subunit G; Validated; Region: PRK07860 1138871010798 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1138871010799 catalytic loop [active] 1138871010800 iron binding site [ion binding]; other site 1138871010801 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1138871010802 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1138871010803 molybdopterin cofactor binding site; other site 1138871010804 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1138871010805 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1138871010806 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1138871010807 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1138871010808 4Fe-4S binding domain; Region: Fer4; pfam00037 1138871010809 4Fe-4S binding domain; Region: Fer4; pfam00037 1138871010810 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1138871010811 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1138871010812 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1138871010813 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1138871010814 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1138871010815 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1138871010816 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1138871010817 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1138871010818 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1138871010819 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1138871010820 Protein of unknown function DUF58; Region: DUF58; pfam01882 1138871010821 MoxR-like ATPases [General function prediction only]; Region: COG0714 1138871010822 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138871010823 Walker A motif; other site 1138871010824 ATP binding site [chemical binding]; other site 1138871010825 Walker B motif; other site 1138871010826 arginine finger; other site 1138871010827 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1138871010828 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138871010829 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138871010830 active site 1138871010831 classical (c) SDRs; Region: SDR_c; cd05233 1138871010832 NAD(P) binding site [chemical binding]; other site 1138871010833 active site 1138871010834 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871010835 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871010836 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1138871010837 putative active site [active] 1138871010838 putative substrate binding site [chemical binding]; other site 1138871010839 ATP binding site [chemical binding]; other site 1138871010840 Phosphotransferase enzyme family; Region: APH; pfam01636 1138871010841 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1138871010842 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138871010843 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138871010844 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138871010845 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1138871010846 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1138871010847 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1138871010848 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1138871010849 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1138871010850 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1138871010851 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1138871010852 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1138871010853 PAS domain; Region: PAS_9; pfam13426 1138871010854 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1138871010855 putative active site [active] 1138871010856 heme pocket [chemical binding]; other site 1138871010857 PAS domain; Region: PAS; smart00091 1138871010858 PAS domain; Region: PAS_9; pfam13426 1138871010859 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1138871010860 anti sigma factor interaction site; other site 1138871010861 regulatory phosphorylation site [posttranslational modification]; other site 1138871010862 CheB methylesterase; Region: CheB_methylest; pfam01339 1138871010863 hydroperoxidase II; Provisional; Region: katE; PRK11249 1138871010864 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1138871010865 tetramer interface [polypeptide binding]; other site 1138871010866 heme binding pocket [chemical binding]; other site 1138871010867 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1138871010868 domain interactions; other site 1138871010869 transcription termination factor Rho; Provisional; Region: PRK12678 1138871010870 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871010871 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 1138871010872 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1138871010873 putative catalytic site [active] 1138871010874 putative metal binding site [ion binding]; other site 1138871010875 putative phosphate binding site [ion binding]; other site 1138871010876 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1138871010877 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1138871010878 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871010879 NAD(P) binding site [chemical binding]; other site 1138871010880 active site 1138871010881 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1138871010882 Multisubunit Na+/H+ antiporter, MnhC subunit [Inorganic ion transport and metabolism]; Region: MnhC; COG1006 1138871010883 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1138871010884 Multisubunit Na+/H+ antiporter, MnhG subunit [Inorganic ion transport and metabolism]; Region: MnhG; COG1320 1138871010885 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 1138871010886 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 1138871010887 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 1138871010888 active site 1138871010889 DNA binding site [nucleotide binding] 1138871010890 Int/Topo IB signature motif; other site 1138871010891 thiamine pyrophosphate protein; Provisional; Region: PRK08273 1138871010892 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1138871010893 PYR/PP interface [polypeptide binding]; other site 1138871010894 dimer interface [polypeptide binding]; other site 1138871010895 tetramer interface [polypeptide binding]; other site 1138871010896 TPP binding site [chemical binding]; other site 1138871010897 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1138871010898 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1138871010899 TPP-binding site [chemical binding]; other site 1138871010900 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1138871010901 Fe-S cluster binding site [ion binding]; other site 1138871010902 active site 1138871010903 Hemerythrin-like domain; Region: Hr-like; cd12108 1138871010904 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1138871010905 PknH-like extracellular domain; Region: PknH_C; pfam14032 1138871010906 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1138871010907 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1138871010908 active site 1138871010909 catalytic tetrad [active] 1138871010910 classical (c) SDRs; Region: SDR_c; cd05233 1138871010911 NAD(P) binding site [chemical binding]; other site 1138871010912 active site 1138871010913 PAS domain S-box; Region: sensory_box; TIGR00229 1138871010914 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1138871010915 putative active site [active] 1138871010916 heme pocket [chemical binding]; other site 1138871010917 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1138871010918 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1138871010919 metal binding site [ion binding]; metal-binding site 1138871010920 active site 1138871010921 I-site; other site 1138871010922 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1138871010923 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1138871010924 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1138871010925 active site 1138871010926 catalytic site [active] 1138871010927 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1138871010928 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1138871010929 NAD binding site [chemical binding]; other site 1138871010930 catalytic Zn binding site [ion binding]; other site 1138871010931 structural Zn binding site [ion binding]; other site 1138871010932 GAF domain; Region: GAF; cl17456 1138871010933 GAF domain; Region: GAF_2; pfam13185 1138871010934 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1138871010935 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1138871010936 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 1138871010937 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 1138871010938 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1138871010939 DNA binding residues [nucleotide binding] 1138871010940 putative dimer interface [polypeptide binding]; other site 1138871010941 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1138871010942 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1138871010943 putative dimer interface [polypeptide binding]; other site 1138871010944 PAS fold; Region: PAS_3; pfam08447 1138871010945 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1138871010946 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1138871010947 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1138871010948 FMN-binding pocket [chemical binding]; other site 1138871010949 flavin binding motif; other site 1138871010950 phosphate binding motif [ion binding]; other site 1138871010951 beta-alpha-beta structure motif; other site 1138871010952 NAD binding pocket [chemical binding]; other site 1138871010953 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1138871010954 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1138871010955 catalytic loop [active] 1138871010956 iron binding site [ion binding]; other site 1138871010957 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138871010958 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1138871010959 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1138871010960 acyl-CoA synthetase; Validated; Region: PRK05850 1138871010961 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1138871010962 acyl-activating enzyme (AAE) consensus motif; other site 1138871010963 active site 1138871010964 thioester reductase domain; Region: Thioester-redct; TIGR01746 1138871010965 Male sterility protein; Region: NAD_binding_4; pfam07993 1138871010966 NAD(P) binding site [chemical binding]; other site 1138871010967 active site 1138871010968 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1138871010969 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1138871010970 short chain dehydrogenase; Provisional; Region: PRK06197 1138871010971 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1138871010972 putative NAD(P) binding site [chemical binding]; other site 1138871010973 active site 1138871010974 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138871010975 mce related protein; Region: MCE; pfam02470 1138871010976 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1138871010977 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138871010978 mce related protein; Region: MCE; pfam02470 1138871010979 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1138871010980 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1138871010981 catalytic residues [active] 1138871010982 dimer interface [polypeptide binding]; other site 1138871010983 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1138871010984 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1138871010985 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 1138871010986 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1138871010987 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1138871010988 ATP binding site [chemical binding]; other site 1138871010989 putative Mg++ binding site [ion binding]; other site 1138871010990 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1138871010991 nucleotide binding region [chemical binding]; other site 1138871010992 ATP-binding site [chemical binding]; other site 1138871010993 Cupin domain; Region: Cupin_2; cl17218 1138871010994 FMN binding site [chemical binding]; other site 1138871010995 Nitroreductase family; Region: Nitroreductase; pfam00881 1138871010996 dimer interface [polypeptide binding]; other site 1138871010997 HD domain protein, cyanamide hydratase family; Region: cyanamide_fam; TIGR03401 1138871010998 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1138871010999 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1138871011000 conserved cys residue [active] 1138871011001 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1138871011002 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1138871011003 hypothetical protein; Validated; Region: PRK00068 1138871011004 Uncharacterized conserved protein [Function unknown]; Region: COG1615 1138871011005 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1138871011006 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1138871011007 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1138871011008 Uncharacterized conserved protein [Function unknown]; Region: COG5282 1138871011009 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1138871011010 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 1138871011011 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1138871011012 ABC1 family; Region: ABC1; pfam03109 1138871011013 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1138871011014 active site 1138871011015 ATP binding site [chemical binding]; other site 1138871011016 Transcription factor WhiB; Region: Whib; pfam02467 1138871011017 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1138871011018 Part of AAA domain; Region: AAA_19; pfam13245 1138871011019 Family description; Region: UvrD_C_2; pfam13538 1138871011020 HRDC domain; Region: HRDC; pfam00570 1138871011021 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1138871011022 catalytic residues [active] 1138871011023 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1138871011024 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1138871011025 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1138871011026 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1138871011027 putative NADH binding site [chemical binding]; other site 1138871011028 putative active site [active] 1138871011029 nudix motif; other site 1138871011030 putative metal binding site [ion binding]; other site 1138871011031 Ion channel; Region: Ion_trans_2; pfam07885 1138871011032 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 1138871011033 TrkA-N domain; Region: TrkA_N; pfam02254 1138871011034 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1138871011035 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1138871011036 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1138871011037 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1138871011038 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1138871011039 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138871011040 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138871011041 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1138871011042 catalytic site [active] 1138871011043 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1138871011044 active site 1138871011045 DNA binding site [nucleotide binding] 1138871011046 TIGR02569 family protein; Region: TIGR02569_actnb 1138871011047 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 1138871011048 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1138871011049 ATP binding site [chemical binding]; other site 1138871011050 substrate interface [chemical binding]; other site 1138871011051 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1138871011052 active site residue [active] 1138871011053 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 1138871011054 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871011055 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871011056 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1138871011057 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1138871011058 dinuclear metal binding motif [ion binding]; other site 1138871011059 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 1138871011060 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1138871011061 ATP binding site [chemical binding]; other site 1138871011062 Mg++ binding site [ion binding]; other site 1138871011063 motif III; other site 1138871011064 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1138871011065 nucleotide binding region [chemical binding]; other site 1138871011066 ATP-binding site [chemical binding]; other site 1138871011067 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1138871011068 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1138871011069 P-loop; other site 1138871011070 Magnesium ion binding site [ion binding]; other site 1138871011071 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1138871011072 Magnesium ion binding site [ion binding]; other site 1138871011073 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1138871011074 catalytic core [active] 1138871011075 isochorismate synthase DhbC; Validated; Region: PRK06923 1138871011076 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1138871011077 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1138871011078 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1138871011079 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1138871011080 Transcription factor WhiB; Region: Whib; pfam02467 1138871011081 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 1138871011082 PAS domain S-box; Region: sensory_box; TIGR00229 1138871011083 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1138871011084 Histidine kinase; Region: HisKA_2; pfam07568 1138871011085 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138871011086 ATP binding site [chemical binding]; other site 1138871011087 Mg2+ binding site [ion binding]; other site 1138871011088 G-X-G motif; other site 1138871011089 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1138871011090 carboxyltransferase (CT) interaction site; other site 1138871011091 biotinylation site [posttranslational modification]; other site 1138871011092 anti-sigma factor, TIGR02949 family; Region: anti_SigH_actin 1138871011093 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 1138871011094 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138871011095 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138871011096 DNA binding residues [nucleotide binding] 1138871011097 short chain dehydrogenase; Provisional; Region: PRK08278 1138871011098 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 1138871011099 NAD(P) binding site [chemical binding]; other site 1138871011100 homodimer interface [polypeptide binding]; other site 1138871011101 active site 1138871011102 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1138871011103 putative deacylase active site [active] 1138871011104 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1138871011105 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1138871011106 NAD(P) binding site [chemical binding]; other site 1138871011107 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1138871011108 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138871011109 active site 1138871011110 metal binding site [ion binding]; metal-binding site 1138871011111 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1138871011112 short chain dehydrogenase; Provisional; Region: PRK07856 1138871011113 classical (c) SDRs; Region: SDR_c; cd05233 1138871011114 NAD(P) binding site [chemical binding]; other site 1138871011115 active site 1138871011116 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1138871011117 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138871011118 classical (c) SDRs; Region: SDR_c; cd05233 1138871011119 NAD(P) binding site [chemical binding]; other site 1138871011120 active site 1138871011121 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871011122 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138871011123 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138871011124 active site 1138871011125 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1138871011126 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1138871011127 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1138871011128 hinge; other site 1138871011129 active site 1138871011130 Predicted GTPases [General function prediction only]; Region: COG1162 1138871011131 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1138871011132 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1138871011133 GTP/Mg2+ binding site [chemical binding]; other site 1138871011134 G4 box; other site 1138871011135 G5 box; other site 1138871011136 G1 box; other site 1138871011137 Switch I region; other site 1138871011138 G2 box; other site 1138871011139 G3 box; other site 1138871011140 Switch II region; other site 1138871011141 Predicted transcriptional regulators [Transcription]; Region: COG1733 1138871011142 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1138871011143 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 1138871011144 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138871011145 dimer interface [polypeptide binding]; other site 1138871011146 active site 1138871011147 Domain of unknown function DUF302; Region: DUF302; pfam03625 1138871011148 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871011149 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871011150 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1138871011151 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1138871011152 putative di-iron ligands [ion binding]; other site 1138871011153 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1138871011154 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1138871011155 FAD binding pocket [chemical binding]; other site 1138871011156 FAD binding motif [chemical binding]; other site 1138871011157 phosphate binding motif [ion binding]; other site 1138871011158 beta-alpha-beta structure motif; other site 1138871011159 NAD binding pocket [chemical binding]; other site 1138871011160 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1138871011161 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1138871011162 catalytic loop [active] 1138871011163 iron binding site [ion binding]; other site 1138871011164 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138871011165 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1138871011166 NnrU protein; Region: NnrU; cl17713 1138871011167 Phospholipid methyltransferase; Region: PEMT; cl17370 1138871011168 HD domain; Region: HD_5; pfam13487 1138871011169 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1138871011170 Zn2+ binding site [ion binding]; other site 1138871011171 Mg2+ binding site [ion binding]; other site 1138871011172 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1138871011173 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1138871011174 DNA binding residues [nucleotide binding] 1138871011175 dimerization interface [polypeptide binding]; other site 1138871011176 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1138871011177 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1138871011178 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1138871011179 30S subunit binding site; other site 1138871011180 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1138871011181 lipoprotein LpqB; Provisional; Region: PRK13616 1138871011182 Sporulation and spore germination; Region: Germane; pfam10646 1138871011183 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1138871011184 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1138871011185 dimer interface [polypeptide binding]; other site 1138871011186 phosphorylation site [posttranslational modification] 1138871011187 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138871011188 ATP binding site [chemical binding]; other site 1138871011189 Mg2+ binding site [ion binding]; other site 1138871011190 G-X-G motif; other site 1138871011191 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1138871011192 dimerization interface [polypeptide binding]; other site 1138871011193 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1138871011194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138871011195 active site 1138871011196 phosphorylation site [posttranslational modification] 1138871011197 intermolecular recognition site; other site 1138871011198 dimerization interface [polypeptide binding]; other site 1138871011199 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1138871011200 DNA binding site [nucleotide binding] 1138871011201 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1138871011202 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1138871011203 TMP-binding site; other site 1138871011204 ATP-binding site [chemical binding]; other site 1138871011205 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1138871011206 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1138871011207 homotetramer interface [polypeptide binding]; other site 1138871011208 ligand binding site [chemical binding]; other site 1138871011209 catalytic site [active] 1138871011210 NAD binding site [chemical binding]; other site 1138871011211 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871011212 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871011213 Rubredoxin [Energy production and conversion]; Region: COG1773 1138871011214 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1138871011215 iron binding site [ion binding]; other site 1138871011216 Rubredoxin [Energy production and conversion]; Region: COG1773 1138871011217 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1138871011218 iron binding site [ion binding]; other site 1138871011219 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 1138871011220 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1138871011221 Di-iron ligands [ion binding]; other site 1138871011222 amino acid transporter; Region: 2A0306; TIGR00909 1138871011223 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1138871011224 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1138871011225 hypothetical protein; Provisional; Region: PRK07236 1138871011226 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1138871011227 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1138871011228 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1138871011229 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 1138871011230 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1138871011231 active site 1138871011232 substrate binding site [chemical binding]; other site 1138871011233 metal binding site [ion binding]; metal-binding site 1138871011234 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 1138871011235 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1138871011236 Transcription factor WhiB; Region: Whib; pfam02467 1138871011237 LPPG:FO 2-phospho-L-lactate transferase; Provisional; Region: PRK13606 1138871011238 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 1138871011239 phosphate binding site [ion binding]; other site 1138871011240 dimer interface [polypeptide binding]; other site 1138871011241 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 1138871011242 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 1138871011243 F420 biosynthesis protein FbiB, C-terminal domain; Region: F420_FbiB_CTERM; TIGR03553 1138871011244 FMN binding site [chemical binding]; other site 1138871011245 dimer interface [polypeptide binding]; other site 1138871011246 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 1138871011247 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1138871011248 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 1138871011249 nudix motif; other site 1138871011250 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1138871011251 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1138871011252 active site 1138871011253 Substrate binding site; other site 1138871011254 Mg++ binding site; other site 1138871011255 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1138871011256 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1138871011257 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1138871011258 Probable Catalytic site; other site 1138871011259 metal-binding site 1138871011260 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1138871011261 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1138871011262 NADP binding site [chemical binding]; other site 1138871011263 active site 1138871011264 putative substrate binding site [chemical binding]; other site 1138871011265 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1138871011266 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1138871011267 TIGR03089 family protein; Region: TIGR03089 1138871011268 Protein of unknown function (DUF1490); Region: DUF1490; pfam07371 1138871011269 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1138871011270 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1138871011271 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1138871011272 active site 1138871011273 motif I; other site 1138871011274 motif II; other site 1138871011275 Cation efflux family; Region: Cation_efflux; cl00316 1138871011276 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138871011277 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138871011278 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138871011279 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138871011280 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1138871011281 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1138871011282 active site 1138871011283 ATP binding site [chemical binding]; other site 1138871011284 substrate binding site [chemical binding]; other site 1138871011285 activation loop (A-loop); other site 1138871011286 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1138871011287 NHL repeat; Region: NHL; pfam01436 1138871011288 NHL repeat; Region: NHL; pfam01436 1138871011289 NHL repeat; Region: NHL; pfam01436 1138871011290 NHL repeat; Region: NHL; pfam01436 1138871011291 NHL repeat; Region: NHL; pfam01436 1138871011292 PBP superfamily domain; Region: PBP_like_2; cl17296 1138871011293 phosphate ABC transporter, ATP-binding protein; Region: 3a0107s01c2; TIGR00972 1138871011294 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1138871011295 Walker A/P-loop; other site 1138871011296 ATP binding site [chemical binding]; other site 1138871011297 Q-loop/lid; other site 1138871011298 ABC transporter signature motif; other site 1138871011299 Walker B; other site 1138871011300 D-loop; other site 1138871011301 H-loop/switch region; other site 1138871011302 PBP superfamily domain; Region: PBP_like_2; cl17296 1138871011303 PBP superfamily domain; Region: PBP_like_2; cl17296 1138871011304 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1138871011305 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138871011306 dimer interface [polypeptide binding]; other site 1138871011307 conserved gate region; other site 1138871011308 putative PBP binding loops; other site 1138871011309 ABC-ATPase subunit interface; other site 1138871011310 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1138871011311 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1138871011312 dimer interface [polypeptide binding]; other site 1138871011313 conserved gate region; other site 1138871011314 ABC-ATPase subunit interface; other site 1138871011315 Response regulator receiver domain; Region: Response_reg; pfam00072 1138871011316 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138871011317 active site 1138871011318 phosphorylation site [posttranslational modification] 1138871011319 intermolecular recognition site; other site 1138871011320 dimerization interface [polypeptide binding]; other site 1138871011321 CHASE3 domain; Region: CHASE3; pfam05227 1138871011322 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1138871011323 dimer interface [polypeptide binding]; other site 1138871011324 phosphorylation site [posttranslational modification] 1138871011325 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138871011326 ATP binding site [chemical binding]; other site 1138871011327 Mg2+ binding site [ion binding]; other site 1138871011328 G-X-G motif; other site 1138871011329 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1138871011330 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138871011331 active site 1138871011332 phosphorylation site [posttranslational modification] 1138871011333 intermolecular recognition site; other site 1138871011334 dimerization interface [polypeptide binding]; other site 1138871011335 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1138871011336 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871011337 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1138871011338 FAD binding site [chemical binding]; other site 1138871011339 homotetramer interface [polypeptide binding]; other site 1138871011340 substrate binding pocket [chemical binding]; other site 1138871011341 catalytic base [active] 1138871011342 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1138871011343 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1138871011344 ATP-grasp domain; Region: ATP-grasp; pfam02222 1138871011345 Predicted membrane protein [Function unknown]; Region: COG2246 1138871011346 GtrA-like protein; Region: GtrA; pfam04138 1138871011347 Bacterial PH domain; Region: DUF304; pfam03703 1138871011348 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1138871011349 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1138871011350 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1138871011351 3-ketosteroid-delta-1-dehydrogenase; Provisional; Region: PRK12837 1138871011352 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1138871011353 acyl-CoA synthetase; Provisional; Region: PRK13388 1138871011354 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871011355 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871011356 active site 1138871011357 CoA binding site [chemical binding]; other site 1138871011358 AMP binding site [chemical binding]; other site 1138871011359 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1138871011360 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1138871011361 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1138871011362 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1138871011363 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1138871011364 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1138871011365 active site 1138871011366 dimer interface [polypeptide binding]; other site 1138871011367 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1138871011368 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1138871011369 active site residue [active] 1138871011370 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1138871011371 active site residue [active] 1138871011372 Fe-S metabolism associated domain; Region: SufE; cl00951 1138871011373 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1138871011374 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1138871011375 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1138871011376 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1138871011377 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1138871011378 carboxyltransferase (CT) interaction site; other site 1138871011379 biotinylation site [posttranslational modification]; other site 1138871011380 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1138871011381 anti sigma factor interaction site; other site 1138871011382 regulatory phosphorylation site [posttranslational modification]; other site 1138871011383 RNA polymerase sigma factor SigF; Reviewed; Region: PRK07122 1138871011384 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138871011385 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1138871011386 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138871011387 DNA binding residues [nucleotide binding] 1138871011388 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1138871011389 L-lysine aminotransferase; Provisional; Region: PRK08297 1138871011390 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1138871011391 inhibitor-cofactor binding pocket; inhibition site 1138871011392 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138871011393 catalytic residue [active] 1138871011394 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1138871011395 AsnC family; Region: AsnC_trans_reg; pfam01037 1138871011396 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 1138871011397 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1138871011398 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138871011399 NAD(P) binding site [chemical binding]; other site 1138871011400 catalytic residues [active] 1138871011401 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871011402 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871011403 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1138871011404 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1138871011405 ATP binding site [chemical binding]; other site 1138871011406 putative Mg++ binding site [ion binding]; other site 1138871011407 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1138871011408 nucleotide binding region [chemical binding]; other site 1138871011409 ATP-binding site [chemical binding]; other site 1138871011410 DEAD/H associated; Region: DEAD_assoc; pfam08494 1138871011411 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1138871011412 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 1138871011413 putative DNA binding site [nucleotide binding]; other site 1138871011414 catalytic residue [active] 1138871011415 putative H2TH interface [polypeptide binding]; other site 1138871011416 putative catalytic residues [active] 1138871011417 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1138871011418 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1138871011419 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138871011420 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1138871011421 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 1138871011422 oligomer interface [polypeptide binding]; other site 1138871011423 metal binding site [ion binding]; metal-binding site 1138871011424 metal binding site [ion binding]; metal-binding site 1138871011425 putative Cl binding site [ion binding]; other site 1138871011426 aspartate ring; other site 1138871011427 basic sphincter; other site 1138871011428 hydrophobic gate; other site 1138871011429 periplasmic entrance; other site 1138871011430 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871011431 PPE family; Region: PPE; pfam00823 1138871011432 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871011433 PPE family; Region: PPE; pfam00823 1138871011434 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1138871011435 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1138871011436 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1138871011437 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1138871011438 active site 1138871011439 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1138871011440 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 1138871011441 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138871011442 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138871011443 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1138871011444 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1138871011445 putative active site pocket [active] 1138871011446 dimerization interface [polypeptide binding]; other site 1138871011447 putative catalytic residue [active] 1138871011448 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138871011449 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138871011450 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1138871011451 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 1138871011452 metal binding site [ion binding]; metal-binding site 1138871011453 putative dimer interface [polypeptide binding]; other site 1138871011454 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1138871011455 amidohydrolase; Region: amidohydrolases; TIGR01891 1138871011456 metal binding site [ion binding]; metal-binding site 1138871011457 Cutinase; Region: Cutinase; pfam01083 1138871011458 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1138871011459 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1138871011460 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1138871011461 active site 1138871011462 substrate binding site [chemical binding]; other site 1138871011463 metal binding site [ion binding]; metal-binding site 1138871011464 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1138871011465 hypothetical protein; Provisional; Region: PRK13685 1138871011466 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1138871011467 metal ion-dependent adhesion site (MIDAS); other site 1138871011468 hypothetical protein; Provisional; Region: PRK13685 1138871011469 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1138871011470 metal ion-dependent adhesion site (MIDAS); other site 1138871011471 Cupin domain; Region: Cupin_2; cl17218 1138871011472 Cupin domain; Region: Cupin_2; pfam07883 1138871011473 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1138871011474 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138871011475 DNA-binding site [nucleotide binding]; DNA binding site 1138871011476 FCD domain; Region: FCD; pfam07729 1138871011477 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1138871011478 adenosine deaminase; Provisional; Region: PRK09358 1138871011479 active site 1138871011480 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1138871011481 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1138871011482 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1138871011483 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 1138871011484 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1138871011485 active site 1138871011486 catalytic motif [active] 1138871011487 Zn binding site [ion binding]; other site 1138871011488 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 1138871011489 putative Iron-sulfur protein interface [polypeptide binding]; other site 1138871011490 putative proximal heme binding site [chemical binding]; other site 1138871011491 putative SdhD-like interface [polypeptide binding]; other site 1138871011492 putative distal heme binding site [chemical binding]; other site 1138871011493 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 1138871011494 putative Iron-sulfur protein interface [polypeptide binding]; other site 1138871011495 putative proximal heme binding site [chemical binding]; other site 1138871011496 putative SdhC-like subunit interface [polypeptide binding]; other site 1138871011497 putative distal heme binding site [chemical binding]; other site 1138871011498 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 1138871011499 L-aspartate oxidase; Provisional; Region: PRK06175 1138871011500 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1138871011501 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1138871011502 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1138871011503 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1138871011504 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1138871011505 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1138871011506 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1138871011507 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138871011508 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138871011509 DNA binding residues [nucleotide binding] 1138871011510 SnoaL-like domain; Region: SnoaL_2; pfam12680 1138871011511 hypothetical protein; Provisional; Region: PRK06541 1138871011512 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1138871011513 inhibitor-cofactor binding pocket; inhibition site 1138871011514 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138871011515 catalytic residue [active] 1138871011516 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1138871011517 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1138871011518 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1138871011519 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138871011520 putative substrate translocation pore; other site 1138871011521 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138871011522 Amidohydrolase; Region: Amidohydro_4; pfam13147 1138871011523 active site 1138871011524 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1138871011525 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1138871011526 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1138871011527 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1138871011528 active site 1138871011529 HIGH motif; other site 1138871011530 dimer interface [polypeptide binding]; other site 1138871011531 KMSKS motif; other site 1138871011532 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138871011533 isocitrate dehydrogenase; Validated; Region: PRK08299 1138871011534 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1138871011535 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 1138871011536 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 1138871011537 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1138871011538 homodimer interface [polypeptide binding]; other site 1138871011539 substrate-cofactor binding pocket; other site 1138871011540 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138871011541 catalytic residue [active] 1138871011542 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1138871011543 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1138871011544 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871011545 S-adenosylmethionine binding site [chemical binding]; other site 1138871011546 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 1138871011547 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138871011548 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138871011549 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138871011550 active site 1138871011551 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138871011552 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 1138871011553 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 1138871011554 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1138871011555 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1138871011556 homodimer interface [polypeptide binding]; other site 1138871011557 NADP binding site [chemical binding]; other site 1138871011558 substrate binding site [chemical binding]; other site 1138871011559 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1138871011560 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 1138871011561 active site 1138871011562 FMN binding site [chemical binding]; other site 1138871011563 substrate binding site [chemical binding]; other site 1138871011564 putative catalytic residue [active] 1138871011565 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138871011566 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1138871011567 phosphopeptide binding site; other site 1138871011568 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138871011569 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1138871011570 phosphopeptide binding site; other site 1138871011571 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1138871011572 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1138871011573 Walker A/P-loop; other site 1138871011574 ATP binding site [chemical binding]; other site 1138871011575 Q-loop/lid; other site 1138871011576 ABC transporter signature motif; other site 1138871011577 Walker B; other site 1138871011578 D-loop; other site 1138871011579 H-loop/switch region; other site 1138871011580 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1138871011581 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1138871011582 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138871011583 phosphopeptide binding site; other site 1138871011584 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1138871011585 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1138871011586 phosphopeptide binding site; other site 1138871011587 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1138871011588 Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily; Region: ABCG_EPDR; cd03213 1138871011589 Walker A/P-loop; other site 1138871011590 ATP binding site [chemical binding]; other site 1138871011591 Q-loop/lid; other site 1138871011592 ABC transporter signature motif; other site 1138871011593 Walker B; other site 1138871011594 D-loop; other site 1138871011595 H-loop/switch region; other site 1138871011596 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1138871011597 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1138871011598 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1138871011599 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1138871011600 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1138871011601 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 1138871011602 G1 box; other site 1138871011603 GTP/Mg2+ binding site [chemical binding]; other site 1138871011604 G2 box; other site 1138871011605 Switch I region; other site 1138871011606 G3 box; other site 1138871011607 Switch II region; other site 1138871011608 G4 box; other site 1138871011609 G5 box; other site 1138871011610 Protein of unknown function (DUF742); Region: DUF742; pfam05331 1138871011611 Uncharacterized distant relative of homeotic protein bithoraxoid [General function prediction only]; Region: COG2018 1138871011612 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1138871011613 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138871011614 ATP binding site [chemical binding]; other site 1138871011615 Mg2+ binding site [ion binding]; other site 1138871011616 G-X-G motif; other site 1138871011617 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871011618 S-adenosylmethionine binding site [chemical binding]; other site 1138871011619 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1138871011620 YCII-related domain; Region: YCII; cl00999 1138871011621 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1138871011622 FMN binding site [chemical binding]; other site 1138871011623 dimer interface [polypeptide binding]; other site 1138871011624 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1138871011625 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1138871011626 active site 1138871011627 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1138871011628 generic binding surface II; other site 1138871011629 generic binding surface I; other site 1138871011630 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1138871011631 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1138871011632 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1138871011633 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447 1138871011634 GIY-YIG motif/motif A; other site 1138871011635 putative active site [active] 1138871011636 putative metal binding site [ion binding]; other site 1138871011637 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 1138871011638 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1138871011639 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 1138871011640 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 1138871011641 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1138871011642 ATP binding site [chemical binding]; other site 1138871011643 putative Mg++ binding site [ion binding]; other site 1138871011644 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 1138871011645 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1138871011646 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1138871011647 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1138871011648 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 1138871011649 dimer interaction site [polypeptide binding]; other site 1138871011650 substrate-binding tunnel; other site 1138871011651 active site 1138871011652 catalytic site [active] 1138871011653 substrate binding site [chemical binding]; other site 1138871011654 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1138871011655 catalytic core [active] 1138871011656 short chain dehydrogenase; Provisional; Region: PRK07201 1138871011657 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 1138871011658 putative NAD(P) binding site [chemical binding]; other site 1138871011659 active site 1138871011660 putative substrate binding site [chemical binding]; other site 1138871011661 classical (c) SDRs; Region: SDR_c; cd05233 1138871011662 NAD(P) binding site [chemical binding]; other site 1138871011663 active site 1138871011664 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1138871011665 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871011666 S-adenosylmethionine binding site [chemical binding]; other site 1138871011667 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 1138871011668 active site 1138871011669 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07910 1138871011670 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1138871011671 dimer interface [polypeptide binding]; other site 1138871011672 active site 1138871011673 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 1138871011674 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 1138871011675 putative active site [active] 1138871011676 putative substrate binding site [chemical binding]; other site 1138871011677 putative FMN binding site [chemical binding]; other site 1138871011678 putative catalytic residues [active] 1138871011679 DNA Polymerase Y-family; Region: PolY_like; cd03468 1138871011680 DNA binding site [nucleotide binding] 1138871011681 GMP synthase; Reviewed; Region: guaA; PRK00074 1138871011682 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1138871011683 AMP/PPi binding site [chemical binding]; other site 1138871011684 candidate oxyanion hole; other site 1138871011685 catalytic triad [active] 1138871011686 potential glutamine specificity residues [chemical binding]; other site 1138871011687 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1138871011688 ATP Binding subdomain [chemical binding]; other site 1138871011689 Ligand Binding sites [chemical binding]; other site 1138871011690 Dimerization subdomain; other site 1138871011691 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871011692 PPE family; Region: PPE; pfam00823 1138871011693 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871011694 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1138871011695 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138871011696 motif II; other site 1138871011697 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1138871011698 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1138871011699 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1138871011700 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1138871011701 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871011702 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871011703 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 1138871011704 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1138871011705 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1138871011706 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1138871011707 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1138871011708 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1138871011709 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1138871011710 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1138871011711 phosphate binding site [ion binding]; other site 1138871011712 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1138871011713 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1138871011714 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1138871011715 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1138871011716 active site 1138871011717 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 1138871011718 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138871011719 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1138871011720 DNA binding residues [nucleotide binding] 1138871011721 Transcription factor WhiB; Region: Whib; pfam02467 1138871011722 transcription elongation factor GreA; Region: greA; TIGR01462 1138871011723 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1138871011724 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1138871011725 iron-sulfur cluster [ion binding]; other site 1138871011726 [2Fe-2S] cluster binding site [ion binding]; other site 1138871011727 Hemerythrin-like domain; Region: Hr-like; cd12108 1138871011728 Fe binding site [ion binding]; other site 1138871011729 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1138871011730 E-class dimer interface [polypeptide binding]; other site 1138871011731 P-class dimer interface [polypeptide binding]; other site 1138871011732 active site 1138871011733 Cu2+ binding site [ion binding]; other site 1138871011734 Zn2+ binding site [ion binding]; other site 1138871011735 Protein of unknown function (DUF1345); Region: DUF1345; pfam07077 1138871011736 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1138871011737 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1138871011738 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1138871011739 ring oligomerisation interface [polypeptide binding]; other site 1138871011740 ATP/Mg binding site [chemical binding]; other site 1138871011741 stacking interactions; other site 1138871011742 hinge regions; other site 1138871011743 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1138871011744 oligomerisation interface [polypeptide binding]; other site 1138871011745 mobile loop; other site 1138871011746 roof hairpin; other site 1138871011747 UGMP family protein; Validated; Region: PRK09604 1138871011748 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1138871011749 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1138871011750 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1138871011751 Coenzyme A binding pocket [chemical binding]; other site 1138871011752 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1138871011753 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 1138871011754 Glycoprotease family; Region: Peptidase_M22; pfam00814 1138871011755 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; pfam02367 1138871011756 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138871011757 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138871011758 alanine racemase; Reviewed; Region: alr; PRK00053 1138871011759 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1138871011760 active site 1138871011761 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1138871011762 dimer interface [polypeptide binding]; other site 1138871011763 substrate binding site [chemical binding]; other site 1138871011764 catalytic residues [active] 1138871011765 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1138871011766 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138871011767 catalytic residue [active] 1138871011768 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1138871011769 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1138871011770 putative substrate binding site [chemical binding]; other site 1138871011771 putative ATP binding site [chemical binding]; other site 1138871011772 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1138871011773 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1138871011774 glutaminase active site [active] 1138871011775 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1138871011776 dimer interface [polypeptide binding]; other site 1138871011777 active site 1138871011778 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1138871011779 dimer interface [polypeptide binding]; other site 1138871011780 active site 1138871011781 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 1138871011782 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1138871011783 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138871011784 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1138871011785 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1138871011786 active site 1138871011787 substrate binding site [chemical binding]; other site 1138871011788 metal binding site [ion binding]; metal-binding site 1138871011789 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1138871011790 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1138871011791 23S rRNA interface [nucleotide binding]; other site 1138871011792 L3 interface [polypeptide binding]; other site 1138871011793 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1138871011794 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1138871011795 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 1138871011796 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1138871011797 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138871011798 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1138871011799 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138871011800 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138871011801 Walker A motif; other site 1138871011802 ATP binding site [chemical binding]; other site 1138871011803 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 1138871011804 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1138871011805 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1138871011806 active site 1138871011807 catalytic residues [active] 1138871011808 type VII secretion protein EccB, Actinobacterial; Region: T7SS_EccB; TIGR03919 1138871011809 Cutinase; Region: Cutinase; pfam01083 1138871011810 Cutinase; Region: Cutinase; pfam01083 1138871011811 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1138871011812 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1138871011813 active site 1138871011814 dimerization interface 3.5A [polypeptide binding]; other site 1138871011815 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1138871011816 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1138871011817 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1138871011818 alphaNTD homodimer interface [polypeptide binding]; other site 1138871011819 alphaNTD - beta interaction site [polypeptide binding]; other site 1138871011820 alphaNTD - beta' interaction site [polypeptide binding]; other site 1138871011821 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1138871011822 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1138871011823 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1138871011824 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1138871011825 RNA binding surface [nucleotide binding]; other site 1138871011826 30S ribosomal protein S11; Validated; Region: PRK05309 1138871011827 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1138871011828 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1138871011829 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1138871011830 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1138871011831 rRNA binding site [nucleotide binding]; other site 1138871011832 predicted 30S ribosome binding site; other site 1138871011833 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1138871011834 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138871011835 active site 1138871011836 phosphorylation site [posttranslational modification] 1138871011837 intermolecular recognition site; other site 1138871011838 dimerization interface [polypeptide binding]; other site 1138871011839 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1138871011840 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138871011841 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138871011842 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1138871011843 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1138871011844 ligand binding site [chemical binding]; other site 1138871011845 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1138871011846 flexible hinge region; other site 1138871011847 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138871011848 ATP binding site [chemical binding]; other site 1138871011849 Mg2+ binding site [ion binding]; other site 1138871011850 G-X-G motif; other site 1138871011851 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1138871011852 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1138871011853 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1138871011854 probable F420-dependent oxidoreductase, Rv3093c family; Region: F420_Rv3093c; TIGR03841 1138871011855 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1138871011856 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1138871011857 NAD binding site [chemical binding]; other site 1138871011858 substrate binding site [chemical binding]; other site 1138871011859 homodimer interface [polypeptide binding]; other site 1138871011860 active site 1138871011861 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1138871011862 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1138871011863 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1138871011864 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1138871011865 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1138871011866 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1138871011867 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1138871011868 active site 1138871011869 metal binding site [ion binding]; metal-binding site 1138871011870 Plastocyanin [Energy production and conversion]; Region: PetE; COG3794 1138871011871 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1138871011872 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1138871011873 iron-sulfur cluster [ion binding]; other site 1138871011874 [2Fe-2S] cluster binding site [ion binding]; other site 1138871011875 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1138871011876 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138871011877 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138871011878 DNA binding residues [nucleotide binding] 1138871011879 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138871011880 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1138871011881 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1138871011882 tetrameric interface [polypeptide binding]; other site 1138871011883 NAD binding site [chemical binding]; other site 1138871011884 catalytic residues [active] 1138871011885 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871011886 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871011887 active site 1138871011888 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1138871011889 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 1138871011890 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1138871011891 MarR family; Region: MarR; pfam01047 1138871011892 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1138871011893 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1138871011894 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138871011895 homodimer interface [polypeptide binding]; other site 1138871011896 catalytic residue [active] 1138871011897 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 1138871011898 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1138871011899 active site 1138871011900 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain; Region: TPP_enzyme_N; pfam02776 1138871011901 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1138871011902 PYR/PP interface [polypeptide binding]; other site 1138871011903 dimer interface [polypeptide binding]; other site 1138871011904 TPP binding site [chemical binding]; other site 1138871011905 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1138871011906 TPP-binding site [chemical binding]; other site 1138871011907 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1138871011908 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1138871011909 Walker A/P-loop; other site 1138871011910 ATP binding site [chemical binding]; other site 1138871011911 Q-loop/lid; other site 1138871011912 ABC transporter signature motif; other site 1138871011913 Walker B; other site 1138871011914 D-loop; other site 1138871011915 H-loop/switch region; other site 1138871011916 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1138871011917 FtsX-like permease family; Region: FtsX; pfam02687 1138871011918 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1138871011919 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 1138871011920 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1138871011921 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1138871011922 Putative zinc-finger; Region: zf-HC2; pfam13490 1138871011923 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 1138871011924 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138871011925 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138871011926 DNA binding residues [nucleotide binding] 1138871011927 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1138871011928 active site 1138871011929 adenylate kinase; Reviewed; Region: adk; PRK00279 1138871011930 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1138871011931 AMP-binding site [chemical binding]; other site 1138871011932 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1138871011933 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1138871011934 SecY translocase; Region: SecY; pfam00344 1138871011935 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138871011936 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138871011937 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1138871011938 Coenzyme A binding pocket [chemical binding]; other site 1138871011939 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1138871011940 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1138871011941 nucleotide binding site [chemical binding]; other site 1138871011942 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1138871011943 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1138871011944 NAD binding site [chemical binding]; other site 1138871011945 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1138871011946 intersubunit interface [polypeptide binding]; other site 1138871011947 active site 1138871011948 Zn2+ binding site [ion binding]; other site 1138871011949 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1138871011950 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1138871011951 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1138871011952 NAD(P) binding site [chemical binding]; other site 1138871011953 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871011954 glucose-1-dehydrogenase; Provisional; Region: PRK06947 1138871011955 NAD(P) binding site [chemical binding]; other site 1138871011956 active site 1138871011957 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138871011958 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138871011959 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138871011960 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138871011961 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138871011962 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138871011963 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1138871011964 tandem repeat interface [polypeptide binding]; other site 1138871011965 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1138871011966 oligomer interface [polypeptide binding]; other site 1138871011967 active site residues [active] 1138871011968 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1138871011969 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1138871011970 tandem repeat interface [polypeptide binding]; other site 1138871011971 oligomer interface [polypeptide binding]; other site 1138871011972 active site residues [active] 1138871011973 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1138871011974 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138871011975 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1138871011976 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1138871011977 23S rRNA binding site [nucleotide binding]; other site 1138871011978 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1138871011979 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1138871011980 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1138871011981 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1138871011982 5S rRNA interface [nucleotide binding]; other site 1138871011983 L27 interface [polypeptide binding]; other site 1138871011984 23S rRNA interface [nucleotide binding]; other site 1138871011985 L5 interface [polypeptide binding]; other site 1138871011986 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1138871011987 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1138871011988 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1138871011989 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1138871011990 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1138871011991 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1138871011992 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1138871011993 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1138871011994 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1138871011995 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1138871011996 RNA binding site [nucleotide binding]; other site 1138871011997 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1138871011998 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138871011999 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138871012000 active site 1138871012001 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1138871012002 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1138871012003 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1138871012004 Sulfatase; Region: Sulfatase; pfam00884 1138871012005 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1138871012006 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1138871012007 putative translocon interaction site; other site 1138871012008 signal recognition particle (SRP54) interaction site; other site 1138871012009 L23 interface [polypeptide binding]; other site 1138871012010 trigger factor interaction site; other site 1138871012011 23S rRNA interface [nucleotide binding]; other site 1138871012012 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1138871012013 23S rRNA interface [nucleotide binding]; other site 1138871012014 5S rRNA interface [nucleotide binding]; other site 1138871012015 putative antibiotic binding site [chemical binding]; other site 1138871012016 L25 interface [polypeptide binding]; other site 1138871012017 L27 interface [polypeptide binding]; other site 1138871012018 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1138871012019 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1138871012020 G-X-X-G motif; other site 1138871012021 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1138871012022 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1138871012023 putative translocon binding site; other site 1138871012024 protein-rRNA interface [nucleotide binding]; other site 1138871012025 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1138871012026 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1138871012027 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1138871012028 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1138871012029 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1138871012030 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1138871012031 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1138871012032 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1138871012033 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871012034 Cytochrome P450; Region: p450; cl12078 1138871012035 dehydrogenase, Rv0697 family; Region: Rv0697; TIGR03970 1138871012036 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1138871012037 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 1138871012038 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1138871012039 mycofactocin system creatininase family protein; Region: mycofact_creat; TIGR03964 1138871012040 heme/flavin dehydrogenase, mycofactocin system; Region: actino_HemFlav; TIGR03966 1138871012041 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1138871012042 phosphate binding site [ion binding]; other site 1138871012043 mycofactocin radical SAM maturase; Region: mycofact_rSAM; TIGR03962 1138871012044 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1138871012045 FeS/SAM binding site; other site 1138871012046 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1138871012047 putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967 1138871012048 mycofactocin precursor; Region: mycofactocin; TIGR03969 1138871012049 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1138871012050 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871012051 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; cl01837 1138871012052 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1138871012053 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1138871012054 active site 1138871012055 catalytic tetrad [active] 1138871012056 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1138871012057 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1138871012058 active site 1138871012059 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1138871012060 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138871012061 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138871012062 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1138871012063 classical (c) SDRs; Region: SDR_c; cd05233 1138871012064 NAD(P) binding site [chemical binding]; other site 1138871012065 active site 1138871012066 Short C-terminal domain; Region: SHOCT; pfam09851 1138871012067 PE family; Region: PE; pfam00934 1138871012068 elongation factor Tu; Reviewed; Region: PRK00049 1138871012069 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1138871012070 G1 box; other site 1138871012071 GEF interaction site [polypeptide binding]; other site 1138871012072 GTP/Mg2+ binding site [chemical binding]; other site 1138871012073 Switch I region; other site 1138871012074 G2 box; other site 1138871012075 G3 box; other site 1138871012076 Switch II region; other site 1138871012077 G4 box; other site 1138871012078 G5 box; other site 1138871012079 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1138871012080 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1138871012081 Antibiotic Binding Site [chemical binding]; other site 1138871012082 elongation factor G; Reviewed; Region: PRK00007 1138871012083 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1138871012084 G1 box; other site 1138871012085 putative GEF interaction site [polypeptide binding]; other site 1138871012086 GTP/Mg2+ binding site [chemical binding]; other site 1138871012087 Switch I region; other site 1138871012088 G2 box; other site 1138871012089 G3 box; other site 1138871012090 Switch II region; other site 1138871012091 G4 box; other site 1138871012092 G5 box; other site 1138871012093 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1138871012094 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1138871012095 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1138871012096 30S ribosomal protein S7; Validated; Region: PRK05302 1138871012097 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1138871012098 S17 interaction site [polypeptide binding]; other site 1138871012099 S8 interaction site; other site 1138871012100 16S rRNA interaction site [nucleotide binding]; other site 1138871012101 streptomycin interaction site [chemical binding]; other site 1138871012102 23S rRNA interaction site [nucleotide binding]; other site 1138871012103 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1138871012104 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871012105 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871012106 WHG domain; Region: WHG; pfam13305 1138871012107 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1138871012108 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1138871012109 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138871012110 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138871012111 substrate binding site [chemical binding]; other site 1138871012112 oxyanion hole (OAH) forming residues; other site 1138871012113 trimer interface [polypeptide binding]; other site 1138871012114 PaaX-like protein; Region: PaaX; pfam07848 1138871012115 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1138871012116 enoyl-CoA hydratase; Provisional; Region: PRK12478 1138871012117 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138871012118 substrate binding site [chemical binding]; other site 1138871012119 oxyanion hole (OAH) forming residues; other site 1138871012120 trimer interface [polypeptide binding]; other site 1138871012121 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1138871012122 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871012123 active site 1138871012124 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1138871012125 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138871012126 endonuclease IV; Provisional; Region: PRK01060 1138871012127 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1138871012128 AP (apurinic/apyrimidinic) site pocket; other site 1138871012129 DNA interaction; other site 1138871012130 Metal-binding active site; metal-binding site 1138871012131 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1138871012132 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1138871012133 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1138871012134 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1138871012135 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1138871012136 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1138871012137 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1138871012138 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1138871012139 G-loop; other site 1138871012140 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1138871012141 DNA binding site [nucleotide binding] 1138871012142 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1138871012143 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1138871012144 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1138871012145 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1138871012146 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1138871012147 RPB10 interaction site [polypeptide binding]; other site 1138871012148 RPB1 interaction site [polypeptide binding]; other site 1138871012149 RPB11 interaction site [polypeptide binding]; other site 1138871012150 RPB3 interaction site [polypeptide binding]; other site 1138871012151 RPB12 interaction site [polypeptide binding]; other site 1138871012152 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1138871012153 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1138871012154 Walker A/P-loop; other site 1138871012155 ATP binding site [chemical binding]; other site 1138871012156 Q-loop/lid; other site 1138871012157 ABC transporter signature motif; other site 1138871012158 Walker B; other site 1138871012159 D-loop; other site 1138871012160 H-loop/switch region; other site 1138871012161 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 1138871012162 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 1138871012163 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871012164 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871012165 WHG domain; Region: WHG; pfam13305 1138871012166 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1138871012167 core dimer interface [polypeptide binding]; other site 1138871012168 peripheral dimer interface [polypeptide binding]; other site 1138871012169 L10 interface [polypeptide binding]; other site 1138871012170 L11 interface [polypeptide binding]; other site 1138871012171 putative EF-Tu interaction site [polypeptide binding]; other site 1138871012172 putative EF-G interaction site [polypeptide binding]; other site 1138871012173 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1138871012174 23S rRNA interface [nucleotide binding]; other site 1138871012175 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1138871012176 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 1138871012177 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1138871012178 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1138871012179 N-terminal catalytic domain of class II alpha-mannosidases and similar proteins; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like; cd10786 1138871012180 active site 1138871012181 catalytic site [active] 1138871012182 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 1138871012183 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 1138871012184 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 1138871012185 DinB superfamily; Region: DinB_2; pfam12867 1138871012186 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1138871012187 DinB superfamily; Region: DinB_2; pfam12867 1138871012188 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1138871012189 ABC1 family; Region: ABC1; pfam03109 1138871012190 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1138871012191 active site 1138871012192 ATP binding site [chemical binding]; other site 1138871012193 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138871012194 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1138871012195 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1138871012196 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871012197 S-adenosylmethionine binding site [chemical binding]; other site 1138871012198 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1138871012199 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871012200 S-adenosylmethionine binding site [chemical binding]; other site 1138871012201 YCII-related domain; Region: YCII; cl00999 1138871012202 YCII-related domain; Region: YCII; cl00999 1138871012203 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1138871012204 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138871012205 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1138871012206 DNA binding residues [nucleotide binding] 1138871012207 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1138871012208 mRNA/rRNA interface [nucleotide binding]; other site 1138871012209 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1138871012210 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1138871012211 23S rRNA interface [nucleotide binding]; other site 1138871012212 L7/L12 interface [polypeptide binding]; other site 1138871012213 putative thiostrepton binding site; other site 1138871012214 L25 interface [polypeptide binding]; other site 1138871012215 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1138871012216 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1138871012217 putative homodimer interface [polypeptide binding]; other site 1138871012218 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1138871012219 heterodimer interface [polypeptide binding]; other site 1138871012220 homodimer interface [polypeptide binding]; other site 1138871012221 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1138871012222 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1138871012223 active site 1138871012224 catalytic site [active] 1138871012225 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 1138871012226 active site 1138871012227 catalytic site [active] 1138871012228 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1138871012229 active site 1138871012230 catalytic site [active] 1138871012231 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1138871012232 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 1138871012233 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1138871012234 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138871012235 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138871012236 substrate binding site [chemical binding]; other site 1138871012237 oxyanion hole (OAH) forming residues; other site 1138871012238 trimer interface [polypeptide binding]; other site 1138871012239 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1138871012240 [4Fe-4S] binding site [ion binding]; other site 1138871012241 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1138871012242 molybdopterin cofactor binding site; other site 1138871012243 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 1138871012244 molybdopterin cofactor binding site; other site 1138871012245 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1138871012246 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1138871012247 active site 1138871012248 nucleophile elbow; other site 1138871012249 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1138871012250 cyanate hydratase; Validated; Region: PRK02866 1138871012251 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1138871012252 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 1138871012253 oligomer interface [polypeptide binding]; other site 1138871012254 active site 1138871012255 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871012256 S-adenosylmethionine binding site [chemical binding]; other site 1138871012257 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 1138871012258 putative FMN binding site [chemical binding]; other site 1138871012259 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1138871012260 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871012261 S-adenosylmethionine binding site [chemical binding]; other site 1138871012262 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 1138871012263 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1138871012264 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1138871012265 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 1138871012266 Part of AAA domain; Region: AAA_19; pfam13245 1138871012267 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1138871012268 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 1138871012269 AAA domain; Region: AAA_30; pfam13604 1138871012270 Family description; Region: UvrD_C_2; pfam13538 1138871012271 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1138871012272 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1138871012273 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138871012274 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138871012275 active site 1138871012276 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138871012277 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138871012278 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1138871012279 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 1138871012280 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 1138871012281 Probable lipoprotein LpqN; Region: Lpp-LpqN; pfam10738 1138871012282 PAS fold; Region: PAS_3; pfam08447 1138871012283 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1138871012284 putative active site [active] 1138871012285 heme pocket [chemical binding]; other site 1138871012286 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1138871012287 galactokinase; Provisional; Region: PRK00555 1138871012288 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1138871012289 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1138871012290 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1138871012291 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1138871012292 dimer interface [polypeptide binding]; other site 1138871012293 active site 1138871012294 Predicted membrane protein [Function unknown]; Region: COG1289 1138871012295 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1138871012296 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871012297 Cytochrome P450; Region: p450; cl12078 1138871012298 hypothetical protein; Provisional; Region: PRK07588 1138871012299 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1138871012300 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138871012301 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138871012302 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1138871012303 NYN domain; Region: NYN; pfam01936 1138871012304 putative metal binding site [ion binding]; other site 1138871012305 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cl14879 1138871012306 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871012307 Cytochrome P450; Region: p450; cl12078 1138871012308 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1138871012309 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1138871012310 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1138871012311 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1138871012312 molybdopterin cofactor binding site; other site 1138871012313 Molydopterin dinucleotide binding domain; Region: Molydop_binding; pfam01568 1138871012314 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1138871012315 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1138871012316 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138871012317 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138871012318 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK12439 1138871012319 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1138871012320 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1138871012321 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1138871012322 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1138871012323 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1138871012324 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1138871012325 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1138871012326 salt bridge; other site 1138871012327 non-specific DNA binding site [nucleotide binding]; other site 1138871012328 sequence-specific DNA binding site [nucleotide binding]; other site 1138871012329 heat shock protein HtpX; Provisional; Region: PRK03072 1138871012330 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1138871012331 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1138871012332 substrate binding pocket [chemical binding]; other site 1138871012333 chain length determination region; other site 1138871012334 substrate-Mg2+ binding site; other site 1138871012335 catalytic residues [active] 1138871012336 aspartate-rich region 1; other site 1138871012337 active site lid residues [active] 1138871012338 aspartate-rich region 2; other site 1138871012339 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1138871012340 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1138871012341 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138871012342 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1138871012343 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871012344 S-adenosylmethionine binding site [chemical binding]; other site 1138871012345 short chain dehydrogenase; Provisional; Region: PRK08263 1138871012346 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1138871012347 NADP binding site [chemical binding]; other site 1138871012348 active site 1138871012349 steroid binding site; other site 1138871012350 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1138871012351 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1138871012352 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1138871012353 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1138871012354 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1138871012355 dimer interface [polypeptide binding]; other site 1138871012356 tetramer interface [polypeptide binding]; other site 1138871012357 PYR/PP interface [polypeptide binding]; other site 1138871012358 TPP binding site [chemical binding]; other site 1138871012359 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1138871012360 TPP-binding site; other site 1138871012361 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1138871012362 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138871012363 TAP-like protein; Region: Abhydrolase_4; pfam08386 1138871012364 O-succinylbenzoate synthase; Provisional; Region: PRK02901 1138871012365 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1138871012366 active site 1138871012367 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1138871012368 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1138871012369 active site 1138871012370 putative phosphatase; Provisional; Region: PRK11587 1138871012371 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138871012372 acyl-CoA synthetase; Validated; Region: PRK06188 1138871012373 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1138871012374 putative active site [active] 1138871012375 putative CoA binding site [chemical binding]; other site 1138871012376 putative AMP binding site [chemical binding]; other site 1138871012377 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871012378 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871012379 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1138871012380 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1138871012381 active site 1138871012382 catalytic tetrad [active] 1138871012383 Domain of unknown function (DUF385); Region: DUF385; cl04387 1138871012384 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138871012385 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1138871012386 substrate binding site [chemical binding]; other site 1138871012387 oxyanion hole (OAH) forming residues; other site 1138871012388 trimer interface [polypeptide binding]; other site 1138871012389 short chain dehydrogenase; Provisional; Region: PRK05866 1138871012390 classical (c) SDRs; Region: SDR_c; cd05233 1138871012391 NAD(P) binding site [chemical binding]; other site 1138871012392 active site 1138871012393 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138871012394 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1138871012395 active site 1138871012396 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1138871012397 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1138871012398 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK07824 1138871012399 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871012400 acyl-activating enzyme (AAE) consensus motif; other site 1138871012401 AMP binding site [chemical binding]; other site 1138871012402 active site 1138871012403 CoA binding site [chemical binding]; other site 1138871012404 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 1138871012405 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1138871012406 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1138871012407 Ligand binding site; other site 1138871012408 Putative Catalytic site; other site 1138871012409 DXD motif; other site 1138871012410 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1138871012411 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871012412 NAD(P) binding site [chemical binding]; other site 1138871012413 active site 1138871012414 5'-methylthioadenosine phosphorylase; Validated; Region: PRK07823 1138871012415 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1138871012416 UbiA prenyltransferase family; Region: UbiA; pfam01040 1138871012417 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1138871012418 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1138871012419 dimer interface [polypeptide binding]; other site 1138871012420 active site 1138871012421 CoA binding pocket [chemical binding]; other site 1138871012422 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1138871012423 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1138871012424 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1138871012425 P-loop; other site 1138871012426 Magnesium ion binding site [ion binding]; other site 1138871012427 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1138871012428 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; COG1333 1138871012429 ResB-like family; Region: ResB; pfam05140 1138871012430 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1138871012431 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1138871012432 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1138871012433 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1138871012434 catalytic residues [active] 1138871012435 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1138871012436 catalytic core [active] 1138871012437 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1138871012438 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1138871012439 inhibitor-cofactor binding pocket; inhibition site 1138871012440 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138871012441 catalytic residue [active] 1138871012442 Domain of unknown function (DUF385); Region: DUF385; cl04387 1138871012443 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1138871012444 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1138871012445 metal binding site [ion binding]; metal-binding site 1138871012446 substrate binding pocket [chemical binding]; other site 1138871012447 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1138871012448 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1138871012449 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1138871012450 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1138871012451 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871012452 acyl-activating enzyme (AAE) consensus motif; other site 1138871012453 AMP binding site [chemical binding]; other site 1138871012454 active site 1138871012455 CoA binding site [chemical binding]; other site 1138871012456 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1138871012457 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1138871012458 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1138871012459 putative NAD(P) binding site [chemical binding]; other site 1138871012460 active site 1138871012461 putative substrate binding site [chemical binding]; other site 1138871012462 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1138871012463 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138871012464 metabolite-proton symporter; Region: 2A0106; TIGR00883 1138871012465 putative substrate translocation pore; other site 1138871012466 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1138871012467 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1138871012468 active site 1138871012469 dimer interface [polypeptide binding]; other site 1138871012470 non-prolyl cis peptide bond; other site 1138871012471 insertion regions; other site 1138871012472 Putative esterase; Region: Esterase; pfam00756 1138871012473 S-formylglutathione hydrolase; Region: PLN02442 1138871012474 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1138871012475 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1138871012476 active site 1138871012477 catalytic triad [active] 1138871012478 oxyanion hole [active] 1138871012479 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1138871012480 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1138871012481 anti sigma factor interaction site; other site 1138871012482 regulatory phosphorylation site [posttranslational modification]; other site 1138871012483 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1138871012484 dimer interface [polypeptide binding]; other site 1138871012485 active site 1138871012486 Schiff base residues; other site 1138871012487 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cd09815 1138871012488 active site 1138871012489 homodimer interface [polypeptide binding]; other site 1138871012490 SAM binding site [chemical binding]; other site 1138871012491 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1138871012492 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1138871012493 active site 1138871012494 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1138871012495 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 1138871012496 domain interfaces; other site 1138871012497 active site 1138871012498 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1138871012499 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1138871012500 tRNA; other site 1138871012501 putative tRNA binding site [nucleotide binding]; other site 1138871012502 putative NADP binding site [chemical binding]; other site 1138871012503 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1138871012504 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1138871012505 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1138871012506 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1138871012507 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138871012508 motif II; other site 1138871012509 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1138871012510 active site 1138871012511 catalytic site [active] 1138871012512 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1138871012513 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1138871012514 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871012515 S-adenosylmethionine binding site [chemical binding]; other site 1138871012516 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1138871012517 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1138871012518 putative acyl-acceptor binding pocket; other site 1138871012519 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1138871012520 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 1138871012521 putative NAD(P) binding site [chemical binding]; other site 1138871012522 active site 1138871012523 putative substrate binding site [chemical binding]; other site 1138871012524 DNA binding domain, excisionase family; Region: excise; TIGR01764 1138871012525 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1138871012526 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1138871012527 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1138871012528 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1138871012529 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1138871012530 active site 2 [active] 1138871012531 active site 1 [active] 1138871012532 Diacylglycerol kinase catalytic domain (presumed); Region: DAGKc; smart00046 1138871012533 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1138871012534 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1138871012535 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1138871012536 DNA interaction; other site 1138871012537 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1138871012538 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1138871012539 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1138871012540 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138871012541 active site 1138871012542 phosphorylation site [posttranslational modification] 1138871012543 intermolecular recognition site; other site 1138871012544 dimerization interface [polypeptide binding]; other site 1138871012545 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1138871012546 DNA binding site [nucleotide binding] 1138871012547 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1138871012548 dimer interface [polypeptide binding]; other site 1138871012549 phosphorylation site [posttranslational modification] 1138871012550 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1138871012551 ATP binding site [chemical binding]; other site 1138871012552 Mg2+ binding site [ion binding]; other site 1138871012553 G-X-G motif; other site 1138871012554 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1138871012555 catalytic core [active] 1138871012556 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1138871012557 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1138871012558 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1138871012559 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 1138871012560 putative ADP-binding pocket [chemical binding]; other site 1138871012561 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1138871012562 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1138871012563 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1138871012564 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871012565 NAD(P) binding site [chemical binding]; other site 1138871012566 active site 1138871012567 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1138871012568 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1138871012569 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_2; cd13432 1138871012570 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1138871012571 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1138871012572 FAD binding domain; Region: FAD_binding_4; pfam01565 1138871012573 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1138871012574 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1138871012575 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1138871012576 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1138871012577 putative active site [active] 1138871012578 catalytic triad [active] 1138871012579 putative dimer interface [polypeptide binding]; other site 1138871012580 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1138871012581 deoxyribose-phosphate aldolase; Provisional; Region: PRK00507 1138871012582 catalytic residue [active] 1138871012583 Protein of unknown function (DUF2599); Region: DUF2599; pfam10783 1138871012584 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 1138871012585 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1138871012586 non-specific DNA binding site [nucleotide binding]; other site 1138871012587 salt bridge; other site 1138871012588 sequence-specific DNA binding site [nucleotide binding]; other site 1138871012589 Predicted membrane protein [Function unknown]; Region: COG2733 1138871012590 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871012591 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871012592 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1138871012593 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871012594 S-adenosylmethionine binding site [chemical binding]; other site 1138871012595 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1138871012596 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871012597 S-adenosylmethionine binding site [chemical binding]; other site 1138871012598 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 1138871012599 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1138871012600 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1138871012601 isocitrate lyase; Provisional; Region: PRK15063 1138871012602 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1138871012603 tetramer interface [polypeptide binding]; other site 1138871012604 active site 1138871012605 Mg2+/Mn2+ binding site [ion binding]; other site 1138871012606 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 1138871012607 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1138871012608 active site 2 [active] 1138871012609 active site 1 [active] 1138871012610 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1138871012611 active site 2 [active] 1138871012612 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1138871012613 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1138871012614 non-specific DNA binding site [nucleotide binding]; other site 1138871012615 salt bridge; other site 1138871012616 sequence-specific DNA binding site [nucleotide binding]; other site 1138871012617 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1138871012618 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1138871012619 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1138871012620 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1138871012621 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 1138871012622 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1138871012623 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138871012624 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1138871012625 Protein of unknown function (DUF779); Region: DUF779; cl01432 1138871012626 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1138871012627 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138871012628 NAD(P) binding site [chemical binding]; other site 1138871012629 catalytic residues [active] 1138871012630 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1138871012631 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138871012632 enoyl-CoA hydratase; Provisional; Region: PRK12478 1138871012633 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138871012634 substrate binding site [chemical binding]; other site 1138871012635 oxyanion hole (OAH) forming residues; other site 1138871012636 trimer interface [polypeptide binding]; other site 1138871012637 Protein of unknown function (DUF2782); Region: DUF2782; pfam11191 1138871012638 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1138871012639 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1138871012640 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1138871012641 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1138871012642 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1138871012643 dimer interface [polypeptide binding]; other site 1138871012644 putative radical transfer pathway; other site 1138871012645 diiron center [ion binding]; other site 1138871012646 tyrosyl radical; other site 1138871012647 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1138871012648 Mycobacterium membrane protein; Region: Mycobact_memb; pfam05423 1138871012649 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871012650 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871012651 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1138871012652 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1138871012653 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 1138871012654 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1138871012655 catalytic residues [active] 1138871012656 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1138871012657 DinB superfamily; Region: DinB_2; pfam12867 1138871012658 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1138871012659 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138871012660 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1138871012661 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 1138871012662 active site 1138871012663 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138871012664 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871012665 PPE family; Region: PPE; pfam00823 1138871012666 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1138871012667 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1138871012668 classical (c) SDRs; Region: SDR_c; cd05233 1138871012669 NAD(P) binding site [chemical binding]; other site 1138871012670 active site 1138871012671 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1138871012672 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1138871012673 ring oligomerisation interface [polypeptide binding]; other site 1138871012674 ATP/Mg binding site [chemical binding]; other site 1138871012675 stacking interactions; other site 1138871012676 hinge regions; other site 1138871012677 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1138871012678 active site 1138871012679 Cupin domain; Region: Cupin_2; pfam07883 1138871012680 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871012681 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1138871012682 short chain dehydrogenase; Provisional; Region: PRK06197 1138871012683 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1138871012684 putative NAD(P) binding site [chemical binding]; other site 1138871012685 active site 1138871012686 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1138871012687 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1138871012688 dimer interface [polypeptide binding]; other site 1138871012689 putative functional site; other site 1138871012690 putative MPT binding site; other site 1138871012691 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 1138871012692 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1138871012693 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1138871012694 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 1138871012695 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 1138871012696 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138871012697 Walker A motif; other site 1138871012698 ATP binding site [chemical binding]; other site 1138871012699 Walker B motif; other site 1138871012700 arginine finger; other site 1138871012701 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138871012702 Walker A motif; other site 1138871012703 ATP binding site [chemical binding]; other site 1138871012704 Walker B motif; other site 1138871012705 arginine finger; other site 1138871012706 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871012707 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871012708 oxidoreductase; Provisional; Region: PRK06196 1138871012709 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1138871012710 putative NAD(P) binding site [chemical binding]; other site 1138871012711 active site 1138871012712 enoyl-CoA hydratase; Provisional; Region: PRK08260 1138871012713 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138871012714 substrate binding site [chemical binding]; other site 1138871012715 oxyanion hole (OAH) forming residues; other site 1138871012716 trimer interface [polypeptide binding]; other site 1138871012717 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1138871012718 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138871012719 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 1138871012720 carboxylate-amine ligase; Provisional; Region: PRK13517 1138871012721 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1138871012722 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1138871012723 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1138871012724 E-class dimer interface [polypeptide binding]; other site 1138871012725 P-class dimer interface [polypeptide binding]; other site 1138871012726 active site 1138871012727 Cu2+ binding site [ion binding]; other site 1138871012728 Zn2+ binding site [ion binding]; other site 1138871012729 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1138871012730 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 1138871012731 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1138871012732 active site 1138871012733 catalytic residues [active] 1138871012734 metal binding site [ion binding]; metal-binding site 1138871012735 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1138871012736 putative catalytic site [active] 1138871012737 putative phosphate binding site [ion binding]; other site 1138871012738 active site 1138871012739 metal binding site A [ion binding]; metal-binding site 1138871012740 DNA binding site [nucleotide binding] 1138871012741 putative AP binding site [nucleotide binding]; other site 1138871012742 putative metal binding site B [ion binding]; other site 1138871012743 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1138871012744 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1138871012745 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138871012746 motif II; other site 1138871012747 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1138871012748 PAS fold; Region: PAS_3; pfam08447 1138871012749 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1138871012750 putative active site [active] 1138871012751 heme pocket [chemical binding]; other site 1138871012752 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1138871012753 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1138871012754 ThiC-associated domain; Region: ThiC-associated; pfam13667 1138871012755 ThiC family; Region: ThiC; pfam01964 1138871012756 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1138871012757 dimer interface [polypeptide binding]; other site 1138871012758 substrate binding site [chemical binding]; other site 1138871012759 ATP binding site [chemical binding]; other site 1138871012760 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1138871012761 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1138871012762 MarR family; Region: MarR; pfam01047 1138871012763 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 1138871012764 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138871012765 Predicted metalloprotease [General function prediction only]; Region: COG2321 1138871012766 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1138871012767 Zn binding site [ion binding]; other site 1138871012768 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1138871012769 Beta-lactamase; Region: Beta-lactamase; pfam00144 1138871012770 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138871012771 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138871012772 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138871012773 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138871012774 active site 1138871012775 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138871012776 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138871012777 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1138871012778 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1138871012779 active site 1138871012780 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1138871012781 Peptidase family M23; Region: Peptidase_M23; pfam01551 1138871012782 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871012783 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1138871012784 NAD(P) binding site [chemical binding]; other site 1138871012785 active site 1138871012786 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1138871012787 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 1138871012788 PA/protease or protease-like domain interface [polypeptide binding]; other site 1138871012789 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 1138871012790 Peptidase family M28; Region: Peptidase_M28; pfam04389 1138871012791 active site 1138871012792 metal binding site [ion binding]; metal-binding site 1138871012793 Predicted aminopeptidases [General function prediction only]; Region: Iap; COG2234 1138871012794 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1138871012795 PA_SaNapH_like: Protease-associated domain containing proteins like Streptomyces anulatus N-acetylpuromycin N-acetylhydrolase (SaNapH).This group contains various PA domain-containing proteins similar SaNapH. Proteins in this group belong to the...; Region: PA_SaNapH_like; cd04816 1138871012796 PA/protease or protease-like domain interface [polypeptide binding]; other site 1138871012797 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 1138871012798 active site 1138871012799 metal binding site [ion binding]; metal-binding site 1138871012800 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 1138871012801 Interferon-induced transmembrane protein; Region: CD225; pfam04505 1138871012802 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 1138871012803 active site 1138871012804 catalytic triad [active] 1138871012805 oxyanion hole [active] 1138871012806 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1138871012807 ThiS interaction site; other site 1138871012808 putative active site [active] 1138871012809 tetramer interface [polypeptide binding]; other site 1138871012810 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1138871012811 thiS-thiF/thiG interaction site; other site 1138871012812 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1138871012813 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1138871012814 thiamine phosphate binding site [chemical binding]; other site 1138871012815 active site 1138871012816 pyrophosphate binding site [ion binding]; other site 1138871012817 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1138871012818 nudix motif; other site 1138871012819 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1138871012820 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1138871012821 substrate binding pocket [chemical binding]; other site 1138871012822 membrane-bound complex binding site; other site 1138871012823 hinge residues; other site 1138871012824 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1138871012825 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1138871012826 active site 1138871012827 ATP binding site [chemical binding]; other site 1138871012828 substrate binding site [chemical binding]; other site 1138871012829 activation loop (A-loop); other site 1138871012830 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1138871012831 putative active site [active] 1138871012832 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1138871012833 propionate/acetate kinase; Provisional; Region: PRK12379 1138871012834 phosphate acetyltransferase; Reviewed; Region: PRK05632 1138871012835 DRTGG domain; Region: DRTGG; pfam07085 1138871012836 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1138871012837 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 1138871012838 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1138871012839 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138871012840 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1138871012841 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138871012842 Leucine carboxyl methyltransferase; Region: LCM; cl01306 1138871012843 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 1138871012844 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871012845 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1138871012846 NAD(P) binding site [chemical binding]; other site 1138871012847 active site 1138871012848 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 1138871012849 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871012850 FAD binding site [chemical binding]; other site 1138871012851 substrate binding pocket [chemical binding]; other site 1138871012852 catalytic base [active] 1138871012853 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871012854 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871012855 active site 1138871012856 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871012857 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871012858 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1138871012859 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138871012860 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 1138871012861 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1138871012862 homodimer interface [polypeptide binding]; other site 1138871012863 substrate-cofactor binding pocket; other site 1138871012864 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138871012865 catalytic residue [active] 1138871012866 Member of the Rhodanese Homology Domain superfamily, subgroup 1. This CD includes the putative rhodanese-related sulfurtransferases of several uncharacterized proteins; Region: RHOD_1; cd01522 1138871012867 active site residue [active] 1138871012868 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1138871012869 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871012870 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1138871012871 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1138871012872 CoenzymeA binding site [chemical binding]; other site 1138871012873 subunit interaction site [polypeptide binding]; other site 1138871012874 PHB binding site; other site 1138871012875 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1138871012876 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1138871012877 GDP-binding site [chemical binding]; other site 1138871012878 ACT binding site; other site 1138871012879 IMP binding site; other site 1138871012880 Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406 1138871012881 catalytic core [active] 1138871012882 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1138871012883 Peptidase family M50; Region: Peptidase_M50; pfam02163 1138871012884 active site 1138871012885 putative substrate binding region [chemical binding]; other site 1138871012886 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1138871012887 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 1138871012888 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1138871012889 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1138871012890 active site 1138871012891 intersubunit interface [polypeptide binding]; other site 1138871012892 zinc binding site [ion binding]; other site 1138871012893 Na+ binding site [ion binding]; other site 1138871012894 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1138871012895 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1138871012896 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 1138871012897 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1138871012898 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1138871012899 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 1138871012900 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1138871012901 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1138871012902 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1138871012903 active site 1138871012904 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1138871012905 classical (c) SDRs; Region: SDR_c; cd05233 1138871012906 NAD(P) binding site [chemical binding]; other site 1138871012907 active site 1138871012908 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871012909 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871012910 active site 1138871012911 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1138871012912 Clp amino terminal domain; Region: Clp_N; pfam02861 1138871012913 Clp amino terminal domain; Region: Clp_N; pfam02861 1138871012914 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138871012915 Walker A motif; other site 1138871012916 ATP binding site [chemical binding]; other site 1138871012917 Walker B motif; other site 1138871012918 arginine finger; other site 1138871012919 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138871012920 Walker A motif; other site 1138871012921 ATP binding site [chemical binding]; other site 1138871012922 Walker B motif; other site 1138871012923 arginine finger; other site 1138871012924 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1138871012925 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1138871012926 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1138871012927 heme-binding site [chemical binding]; other site 1138871012928 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 1138871012929 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 1138871012930 FAD binding pocket [chemical binding]; other site 1138871012931 FAD binding motif [chemical binding]; other site 1138871012932 phosphate binding motif [ion binding]; other site 1138871012933 beta-alpha-beta structure motif; other site 1138871012934 NAD binding pocket [chemical binding]; other site 1138871012935 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 1138871012936 active site 1138871012937 catalytic residues [active] 1138871012938 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 1138871012939 DNA binding residues [nucleotide binding] 1138871012940 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1138871012941 putative dimer interface [polypeptide binding]; other site 1138871012942 chaperone protein DnaJ; Provisional; Region: PRK14279 1138871012943 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1138871012944 HSP70 interaction site [polypeptide binding]; other site 1138871012945 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1138871012946 Zn binding sites [ion binding]; other site 1138871012947 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1138871012948 dimer interface [polypeptide binding]; other site 1138871012949 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1138871012950 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1138871012951 dimer interface [polypeptide binding]; other site 1138871012952 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1138871012953 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1138871012954 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1138871012955 nucleotide binding site [chemical binding]; other site 1138871012956 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1138871012957 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138871012958 putative substrate translocation pore; other site 1138871012959 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138871012960 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1138871012961 nucleotide binding site [chemical binding]; other site 1138871012962 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1138871012963 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1138871012964 4Fe-4S binding domain; Region: Fer4; pfam00037 1138871012965 Cysteine-rich domain; Region: CCG; pfam02754 1138871012966 Cysteine-rich domain; Region: CCG; pfam02754 1138871012967 aminotransferase AlaT; Validated; Region: PRK09265 1138871012968 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1138871012969 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1138871012970 homodimer interface [polypeptide binding]; other site 1138871012971 catalytic residue [active] 1138871012972 YibE/F-like protein; Region: YibE_F; pfam07907 1138871012973 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1138871012974 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1138871012975 substrate binding site; other site 1138871012976 tetramer interface; other site 1138871012977 SnoaL-like domain; Region: SnoaL_2; pfam12680 1138871012978 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 1138871012979 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1138871012980 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871012981 S-adenosylmethionine binding site [chemical binding]; other site 1138871012982 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138871012983 putative substrate translocation pore; other site 1138871012984 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1138871012985 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1138871012986 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1138871012987 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1138871012988 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1138871012989 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1138871012990 trimer interface [polypeptide binding]; other site 1138871012991 active site 1138871012992 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1138871012993 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1138871012994 DNA binding site [nucleotide binding] 1138871012995 Int/Topo IB signature motif; other site 1138871012996 active site 1138871012997 Winged helix-turn helix; Region: HTH_29; pfam13551 1138871012998 Helix-turn-helix domain; Region: HTH_28; pfam13518 1138871012999 Homeodomain-like domain; Region: HTH_32; pfam13565 1138871013000 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1138871013001 Integrase core domain; Region: rve; pfam00665 1138871013002 Integrase core domain; Region: rve_3; pfam13683 1138871013003 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 1138871013004 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 1138871013005 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1138871013006 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138871013007 Emopamil binding protein; Region: EBP; pfam05241 1138871013008 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1138871013009 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1138871013010 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1138871013011 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138871013012 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138871013013 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1138871013014 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1138871013015 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1138871013016 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1138871013017 active site 1138871013018 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1138871013019 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1138871013020 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465 1138871013021 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 1138871013022 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1138871013023 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 1138871013024 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1138871013025 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 1138871013026 active site 1138871013027 catalytic residues [active] 1138871013028 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1138871013029 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1138871013030 NAD(P) binding site [chemical binding]; other site 1138871013031 substrate binding site [chemical binding]; other site 1138871013032 dimer interface [polypeptide binding]; other site 1138871013033 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1138871013034 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1138871013035 nucleotide binding site [chemical binding]; other site 1138871013036 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871013037 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871013038 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1138871013039 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 1138871013040 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1138871013041 active site 1138871013042 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1138871013043 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 1138871013044 putative FMN binding site [chemical binding]; other site 1138871013045 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1138871013046 Sulfatase; Region: Sulfatase; pfam00884 1138871013047 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 1138871013048 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871013049 S-adenosylmethionine binding site [chemical binding]; other site 1138871013050 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138871013051 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138871013052 type VII secretion protein EccE; Region: T7SS_EccE; TIGR03923 1138871013053 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1138871013054 Subtilase family; Region: Peptidase_S8; pfam00082 1138871013055 catalytic residues [active] 1138871013056 catalytic residues [active] 1138871013057 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 1138871013058 type VII secretion integral membrane protein EccD; Region: T7SS_EccD; TIGR03920 1138871013059 EspG family; Region: ESX-1_EspG; pfam14011 1138871013060 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1138871013061 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871013062 PPE family; Region: PPE; pfam00823 1138871013063 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1138871013064 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138871013065 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1138871013066 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138871013067 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138871013068 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1138871013069 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 1138871013070 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138871013071 Walker A motif; other site 1138871013072 ATP binding site [chemical binding]; other site 1138871013073 Walker B motif; other site 1138871013074 arginine finger; other site 1138871013075 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138871013076 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138871013077 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1138871013078 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1138871013079 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1138871013080 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1138871013081 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1138871013082 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1138871013083 30S ribosomal protein S18; Provisional; Region: PRK13401 1138871013084 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871013085 PPE family; Region: PPE; pfam00823 1138871013086 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1138871013087 Condensation domain; Region: Condensation; pfam00668 1138871013088 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1138871013089 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138871013090 Zn binding site [ion binding]; other site 1138871013091 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871013092 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871013093 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138871013094 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871013095 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871013096 active site 1138871013097 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871013098 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 1138871013099 FAD binding site [chemical binding]; other site 1138871013100 substrate binding site [chemical binding]; other site 1138871013101 catalytic base [active] 1138871013102 acyl-CoA synthetase; Validated; Region: PRK07788 1138871013103 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871013104 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871013105 active site 1138871013106 CoA binding site [chemical binding]; other site 1138871013107 AMP binding site [chemical binding]; other site 1138871013108 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 1138871013109 nucleotide binding site [chemical binding]; other site 1138871013110 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1138871013111 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138871013112 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1138871013113 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1138871013114 intersubunit interface [polypeptide binding]; other site 1138871013115 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1138871013116 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 1138871013117 Allophanate hydrolase subunit 2 [Amino acid transport and metabolism]; Region: DUR1; COG1984 1138871013118 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1138871013119 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 1138871013120 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1138871013121 active site 1138871013122 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 1138871013123 DNA binding site [nucleotide binding] 1138871013124 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1138871013125 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1138871013126 putative active site [active] 1138871013127 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 1138871013128 active site 1138871013129 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1138871013130 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 1138871013131 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138871013132 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1138871013133 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1138871013134 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1138871013135 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1138871013136 putative dimer interface [polypeptide binding]; other site 1138871013137 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1138871013138 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1138871013139 tetramer interface [polypeptide binding]; other site 1138871013140 active site 1138871013141 Mg2+/Mn2+ binding site [ion binding]; other site 1138871013142 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 1138871013143 L-aspartate oxidase; Provisional; Region: PRK06175 1138871013144 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1138871013145 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 1138871013146 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1138871013147 catalytic loop [active] 1138871013148 iron binding site [ion binding]; other site 1138871013149 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 1138871013150 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 1138871013151 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1138871013152 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1138871013153 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1138871013154 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1138871013155 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 1138871013156 FAD binding site [chemical binding]; other site 1138871013157 substrate binding site [chemical binding]; other site 1138871013158 catalytic residues [active] 1138871013159 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1138871013160 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1138871013161 MarR family; Region: MarR_2; pfam12802 1138871013162 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1138871013163 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1138871013164 active site 1138871013165 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 1138871013166 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1138871013167 dimer interface [polypeptide binding]; other site 1138871013168 active site 1138871013169 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 1138871013170 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871013171 NAD(P) binding site [chemical binding]; other site 1138871013172 active site 1138871013173 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1138871013174 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1138871013175 active site 2 [active] 1138871013176 active site 1 [active] 1138871013177 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 1138871013178 Cl- selectivity filter; other site 1138871013179 Cl- binding residues [ion binding]; other site 1138871013180 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1138871013181 pore gating glutamate residue; other site 1138871013182 dimer interface [polypeptide binding]; other site 1138871013183 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871013184 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871013185 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1138871013186 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1138871013187 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 1138871013188 Protein of unknown function (DUF2613); Region: DUF2613; pfam11021 1138871013189 Domain of unknown function (DUF3367); Region: DUF3367; pfam11847 1138871013190 Lipase maturation factor; Region: LMF1; pfam06762 1138871013191 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1138871013192 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1138871013193 substrate binding pocket [chemical binding]; other site 1138871013194 membrane-bound complex binding site; other site 1138871013195 hinge residues; other site 1138871013196 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871013197 PPE family; Region: PPE; pfam00823 1138871013198 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138871013199 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871013200 PPE family; Region: PPE; pfam00823 1138871013201 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138871013202 Protein of unknown function (DUF732); Region: DUF732; pfam05305 1138871013203 formate dehydrogenase; Provisional; Region: PRK07574 1138871013204 NAD-dependent Formate Dehydrogenase (FDH); Region: FDH; cd05302 1138871013205 dimerization interface [polypeptide binding]; other site 1138871013206 ligand binding site [chemical binding]; other site 1138871013207 NAD binding site [chemical binding]; other site 1138871013208 catalytic site [active] 1138871013209 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1138871013210 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1138871013211 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1138871013212 dimerization interface [polypeptide binding]; other site 1138871013213 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 1138871013214 Protein of unknown function, DUF488; Region: DUF488; pfam04343 1138871013215 Helix-turn-helix domain; Region: HTH_20; pfam12840 1138871013216 putative DNA binding site [nucleotide binding]; other site 1138871013217 Predicted transcriptional regulator [Transcription]; Region: COG2345 1138871013218 putative Zn2+ binding site [ion binding]; other site 1138871013219 Suppression of tumorigenicity 7; Region: ST7; cd11557 1138871013220 Domain of unknown function (DUF309); Region: DUF309; pfam03745 1138871013221 acetolactate synthase; Reviewed; Region: PRK08322 1138871013222 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1138871013223 PYR/PP interface [polypeptide binding]; other site 1138871013224 dimer interface [polypeptide binding]; other site 1138871013225 TPP binding site [chemical binding]; other site 1138871013226 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1138871013227 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1138871013228 TPP-binding site [chemical binding]; other site 1138871013229 dimer interface [polypeptide binding]; other site 1138871013230 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1138871013231 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1138871013232 NAD(P) binding site [chemical binding]; other site 1138871013233 catalytic residues [active] 1138871013234 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 1138871013235 active site 1138871013236 diiron metal binding site [ion binding]; other site 1138871013237 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871013238 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871013239 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871013240 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1138871013241 active site 1138871013242 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1138871013243 active site 1138871013244 substrate binding pocket [chemical binding]; other site 1138871013245 homodimer interaction site [polypeptide binding]; other site 1138871013246 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871013247 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 1138871013248 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871013249 AMP binding site [chemical binding]; other site 1138871013250 active site 1138871013251 acyl-activating enzyme (AAE) consensus motif; other site 1138871013252 acyl-activating enzyme (AAE) consensus motif; other site 1138871013253 CoA binding site [chemical binding]; other site 1138871013254 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 1138871013255 O-methyltransferase; Region: Methyltransf_2; pfam00891 1138871013256 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1138871013257 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 1138871013258 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1138871013259 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1138871013260 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1138871013261 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1138871013262 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1138871013263 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1138871013264 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 1138871013265 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138871013266 NAD binding site [chemical binding]; other site 1138871013267 catalytic residues [active] 1138871013268 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871013269 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871013270 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1138871013271 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871013272 acyl-activating enzyme (AAE) consensus motif; other site 1138871013273 AMP binding site [chemical binding]; other site 1138871013274 active site 1138871013275 CoA binding site [chemical binding]; other site 1138871013276 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 1138871013277 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871013278 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871013279 enoyl-CoA hydratase; Provisional; Region: PRK08252 1138871013280 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138871013281 substrate binding site [chemical binding]; other site 1138871013282 oxyanion hole (OAH) forming residues; other site 1138871013283 trimer interface [polypeptide binding]; other site 1138871013284 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1138871013285 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1138871013286 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1138871013287 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138871013288 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138871013289 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138871013290 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1138871013291 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1138871013292 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1138871013293 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138871013294 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138871013295 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138871013296 active site 1138871013297 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138871013298 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1138871013299 active site 2 [active] 1138871013300 active site 1 [active] 1138871013301 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1138871013302 active site 2 [active] 1138871013303 active site 1 [active] 1138871013304 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871013305 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871013306 active site 1138871013307 Domain of unknown function (DUF222); Region: DUF222; pfam02720 1138871013308 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1138871013309 active site 1138871013310 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1138871013311 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1138871013312 substrate binding site [chemical binding]; other site 1138871013313 oxyanion hole (OAH) forming residues; other site 1138871013314 trimer interface [polypeptide binding]; other site 1138871013315 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 1138871013316 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871013317 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1138871013318 acyl-activating enzyme (AAE) consensus motif; other site 1138871013319 acyl-activating enzyme (AAE) consensus motif; other site 1138871013320 putative AMP binding site [chemical binding]; other site 1138871013321 putative active site [active] 1138871013322 putative CoA binding site [chemical binding]; other site 1138871013323 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1138871013324 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1138871013325 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1138871013326 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1138871013327 metal binding site [ion binding]; metal-binding site 1138871013328 active site 1138871013329 I-site; other site 1138871013330 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1138871013331 active site 1138871013332 substrate-binding site [chemical binding]; other site 1138871013333 metal-binding site [ion binding] 1138871013334 GTP binding site [chemical binding]; other site 1138871013335 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1138871013336 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1138871013337 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871013338 S-adenosylmethionine binding site [chemical binding]; other site 1138871013339 LabA_like proteins; Region: LabA_like; cd06167 1138871013340 putative metal binding site [ion binding]; other site 1138871013341 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 1138871013342 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1138871013343 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1138871013344 Predicted integral membrane protein [Function unknown]; Region: COG0392 1138871013345 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 1138871013346 Protein export membrane protein; Region: SecD_SecF; cl14618 1138871013347 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 1138871013348 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1138871013349 non-specific DNA binding site [nucleotide binding]; other site 1138871013350 salt bridge; other site 1138871013351 sequence-specific DNA binding site [nucleotide binding]; other site 1138871013352 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1138871013353 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1138871013354 active site 1138871013355 Zn binding site [ion binding]; other site 1138871013356 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1138871013357 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1138871013358 molybdopterin cofactor binding site; other site 1138871013359 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1138871013360 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 1138871013361 putative molybdopterin cofactor binding site; other site 1138871013362 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871013363 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871013364 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1138871013365 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1138871013366 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1138871013367 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1138871013368 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138871013369 putative substrate translocation pore; other site 1138871013370 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1138871013371 putative homodimer interface [polypeptide binding]; other site 1138871013372 putative homotetramer interface [polypeptide binding]; other site 1138871013373 putative allosteric switch controlling residues; other site 1138871013374 putative metal binding site [ion binding]; other site 1138871013375 putative homodimer-homodimer interface [polypeptide binding]; other site 1138871013376 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1138871013377 SPW repeat; Region: SPW; pfam03779 1138871013378 SPW repeat; Region: SPW; pfam03779 1138871013379 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1138871013380 FMN binding site [chemical binding]; other site 1138871013381 substrate binding site [chemical binding]; other site 1138871013382 putative catalytic residue [active] 1138871013383 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1138871013384 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871013385 S-adenosylmethionine binding site [chemical binding]; other site 1138871013386 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1138871013387 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1138871013388 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1138871013389 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1138871013390 putative metallohydrolase, TIGR04338 family; Region: HEXXH_Rv0185 1138871013391 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 1138871013392 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1138871013393 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138871013394 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1138871013395 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138871013396 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1138871013397 SnoaL-like domain; Region: SnoaL_2; pfam12680 1138871013398 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138871013399 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1138871013400 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1138871013401 Pirin-related protein [General function prediction only]; Region: COG1741 1138871013402 Pirin; Region: Pirin; pfam02678 1138871013403 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1138871013404 Protein of unknown function (DUF3533); Region: DUF3533; pfam12051 1138871013405 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1138871013406 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1138871013407 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1138871013408 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1138871013409 RDD family; Region: RDD; pfam06271 1138871013410 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138871013411 mce related protein; Region: MCE; pfam02470 1138871013412 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138871013413 mce related protein; Region: MCE; pfam02470 1138871013414 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138871013415 mce related protein; Region: MCE; pfam02470 1138871013416 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138871013417 mce related protein; Region: MCE; pfam02470 1138871013418 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138871013419 mce related protein; Region: MCE; pfam02470 1138871013420 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 1138871013421 mce related protein; Region: MCE; pfam02470 1138871013422 Protein of unknown function (DUF3407); Region: DUF3407; pfam11887 1138871013423 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1138871013424 Permease; Region: Permease; pfam02405 1138871013425 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1138871013426 Permease; Region: Permease; pfam02405 1138871013427 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07786 1138871013428 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871013429 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1138871013430 acyl-activating enzyme (AAE) consensus motif; other site 1138871013431 acyl-activating enzyme (AAE) consensus motif; other site 1138871013432 putative AMP binding site [chemical binding]; other site 1138871013433 putative active site [active] 1138871013434 putative CoA binding site [chemical binding]; other site 1138871013435 Predicted transcriptional regulators [Transcription]; Region: COG1725 1138871013436 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138871013437 DNA-binding site [nucleotide binding]; DNA binding site 1138871013438 FCD domain; Region: FCD; pfam07729 1138871013439 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 1138871013440 putative hydrophobic ligand binding site [chemical binding]; other site 1138871013441 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1138871013442 active site 1138871013443 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1138871013444 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1138871013445 NAD(P) binding site [chemical binding]; other site 1138871013446 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1138871013447 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1138871013448 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138871013449 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138871013450 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1138871013451 classical (c) SDRs; Region: SDR_c; cd05233 1138871013452 NAD(P) binding site [chemical binding]; other site 1138871013453 active site 1138871013454 SnoaL-like domain; Region: SnoaL_4; pfam13577 1138871013455 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1138871013456 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1138871013457 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1138871013458 NAD(P) binding site [chemical binding]; other site 1138871013459 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871013460 Cytochrome P450; Region: p450; cl12078 1138871013461 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138871013462 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138871013463 short chain dehydrogenase; Validated; Region: PRK08264 1138871013464 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871013465 NAD(P) binding site [chemical binding]; other site 1138871013466 active site 1138871013467 Domain of unknown function (DUF427); Region: DUF427; cl00998 1138871013468 Domain of unknown function (DUF427); Region: DUF427; pfam04248 1138871013469 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871013470 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871013471 active site 1138871013472 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 1138871013473 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1138871013474 acyl-CoA thioesterase II; Region: tesB; TIGR00189 1138871013475 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1138871013476 active site 1138871013477 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1138871013478 catalytic triad [active] 1138871013479 dimer interface [polypeptide binding]; other site 1138871013480 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1138871013481 hydrophobic ligand binding site; other site 1138871013482 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1138871013483 Strictosidine synthase; Region: Str_synth; pfam03088 1138871013484 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1138871013485 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871013486 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871013487 SIR2-like domain; Region: SIR2_2; pfam13289 1138871013488 Domain of unknown function DUF87; Region: DUF87; pfam01935 1138871013489 HerA helicase [Replication, recombination, and repair]; Region: COG0433 1138871013490 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1138871013491 FAD binding domain; Region: FAD_binding_4; pfam01565 1138871013492 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871013493 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138871013494 NAD(P) binding site [chemical binding]; other site 1138871013495 active site 1138871013496 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1138871013497 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138871013498 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1138871013499 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1138871013500 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871013501 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871013502 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 1138871013503 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1138871013504 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1138871013505 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1138871013506 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1138871013507 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1138871013508 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1138871013509 ligand binding site [chemical binding]; other site 1138871013510 homodimer interface [polypeptide binding]; other site 1138871013511 NAD(P) binding site [chemical binding]; other site 1138871013512 trimer interface B [polypeptide binding]; other site 1138871013513 trimer interface A [polypeptide binding]; other site 1138871013514 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 1138871013515 SnoaL-like domain; Region: SnoaL_2; pfam12680 1138871013516 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871013517 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871013518 active site 1138871013519 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 1138871013520 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1138871013521 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1138871013522 short chain dehydrogenase; Provisional; Region: PRK07791 1138871013523 (3R)-hydroxyacyl-CoA dehydrogenase-like, classical(c)-like SDRs; Region: hydroxyacyl-CoA-like_DH_SDR_c-like; cd05353 1138871013524 NAD binding site [chemical binding]; other site 1138871013525 homodimer interface [polypeptide binding]; other site 1138871013526 active site 1138871013527 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1138871013528 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 1138871013529 NAD(P) binding site [chemical binding]; other site 1138871013530 catalytic residues [active] 1138871013531 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1138871013532 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1138871013533 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138871013534 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138871013535 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138871013536 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1138871013537 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871013538 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871013539 Pirin-related protein [General function prediction only]; Region: COG1741 1138871013540 Pirin; Region: Pirin; pfam02678 1138871013541 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1138871013542 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1138871013543 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1138871013544 dimerization interface [polypeptide binding]; other site 1138871013545 DPS ferroxidase diiron center [ion binding]; other site 1138871013546 ion pore; other site 1138871013547 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1138871013548 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1138871013549 minor groove reading motif; other site 1138871013550 helix-hairpin-helix signature motif; other site 1138871013551 active site 1138871013552 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1138871013553 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2343 1138871013554 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1138871013555 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 1138871013556 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1138871013557 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871013558 NAD(P) binding site [chemical binding]; other site 1138871013559 active site 1138871013560 SnoaL-like domain; Region: SnoaL_2; pfam12680 1138871013561 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1138871013562 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1138871013563 Cytochrome P450; Region: p450; cl12078 1138871013564 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871013565 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871013566 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 1138871013567 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138871013568 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1138871013569 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871013570 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871013571 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138871013572 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 1138871013573 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1138871013574 hydrophobic ligand binding site; other site 1138871013575 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1138871013576 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1138871013577 putative di-iron ligands [ion binding]; other site 1138871013578 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_2; cd06216 1138871013579 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1138871013580 FAD binding pocket [chemical binding]; other site 1138871013581 FAD binding motif [chemical binding]; other site 1138871013582 phosphate binding motif [ion binding]; other site 1138871013583 beta-alpha-beta structure motif; other site 1138871013584 NAD binding pocket [chemical binding]; other site 1138871013585 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1138871013586 catalytic loop [active] 1138871013587 iron binding site [ion binding]; other site 1138871013588 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 1138871013589 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871013590 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1138871013591 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1138871013592 Coenzyme A binding pocket [chemical binding]; other site 1138871013593 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 1138871013594 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1138871013595 Hemerythrin-like domain; Region: Hr-like; cd12108 1138871013596 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1138871013597 dimanganese center [ion binding]; other site 1138871013598 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1138871013599 GAF domain; Region: GAF; pfam01590 1138871013600 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 1138871013601 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 1138871013602 putative active site [active] 1138871013603 putative catalytic site [active] 1138871013604 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138871013605 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1138871013606 Domain of unknown function DUF302; Region: DUF302; pfam03625 1138871013607 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1138871013608 active site 1138871013609 metal binding site [ion binding]; metal-binding site 1138871013610 homotetramer interface [polypeptide binding]; other site 1138871013611 MarR family; Region: MarR_2; pfam12802 1138871013612 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1138871013613 Daunorubicin/doxorubicin resistance ATP-binding protein; Region: ABC_DrrA; cd03265 1138871013614 Walker A/P-loop; other site 1138871013615 ATP binding site [chemical binding]; other site 1138871013616 Q-loop/lid; other site 1138871013617 ABC transporter signature motif; other site 1138871013618 Walker B; other site 1138871013619 D-loop; other site 1138871013620 H-loop/switch region; other site 1138871013621 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1138871013622 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1138871013623 Predicted esterase [General function prediction only]; Region: COG0627 1138871013624 Predicted membrane protein [Function unknown]; Region: COG3619 1138871013625 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 1138871013626 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1138871013627 trehalose synthase; Region: treS_nterm; TIGR02456 1138871013628 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1138871013629 active site 1138871013630 catalytic site [active] 1138871013631 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1138871013632 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1138871013633 PDZ domain; Region: PDZ_2; pfam13180 1138871013634 protein binding site [polypeptide binding]; other site 1138871013635 PPOX class probable F420-dependent enzyme, Rv0121 family; Region: Rv0121_F420; TIGR03668 1138871013636 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 1138871013637 elongation factor G; Reviewed; Region: PRK12740 1138871013638 G1 box; other site 1138871013639 putative GEF interaction site [polypeptide binding]; other site 1138871013640 GTP/Mg2+ binding site [chemical binding]; other site 1138871013641 Switch I region; other site 1138871013642 G2 box; other site 1138871013643 G3 box; other site 1138871013644 Switch II region; other site 1138871013645 G4 box; other site 1138871013646 G5 box; other site 1138871013647 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1138871013648 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1138871013649 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1138871013650 acyl-CoA synthetase; Validated; Region: PRK05852 1138871013651 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871013652 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871013653 acyl-activating enzyme (AAE) consensus motif; other site 1138871013654 acyl-activating enzyme (AAE) consensus motif; other site 1138871013655 AMP binding site [chemical binding]; other site 1138871013656 active site 1138871013657 CoA binding site [chemical binding]; other site 1138871013658 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 1138871013659 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1138871013660 PYR/PP interface [polypeptide binding]; other site 1138871013661 dimer interface [polypeptide binding]; other site 1138871013662 TPP binding site [chemical binding]; other site 1138871013663 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1138871013664 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1138871013665 TPP-binding site; other site 1138871013666 dimer interface [polypeptide binding]; other site 1138871013667 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1138871013668 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1138871013669 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1138871013670 dimerization interface [polypeptide binding]; other site 1138871013671 IgD-like repeat domain of mycobacterial L,D-transpeptidases; Region: LDT_IgD_like_1; cd13431 1138871013672 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1138871013673 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1138871013674 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1138871013675 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871013676 acyl-activating enzyme (AAE) consensus motif; other site 1138871013677 AMP binding site [chemical binding]; other site 1138871013678 active site 1138871013679 CoA binding site [chemical binding]; other site 1138871013680 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1138871013681 Putative dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3320 1138871013682 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1138871013683 putative NAD(P) binding site [chemical binding]; other site 1138871013684 active site 1138871013685 putative substrate binding site [chemical binding]; other site 1138871013686 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1138871013687 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1138871013688 putative NAD(P) binding site [chemical binding]; other site 1138871013689 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1138871013690 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1138871013691 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1138871013692 S-adenosylmethionine binding site [chemical binding]; other site 1138871013693 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1138871013694 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1138871013695 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1138871013696 active site 1138871013697 catalytic triad [active] 1138871013698 oxyanion hole [active] 1138871013699 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 1138871013700 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1138871013701 NAD binding site [chemical binding]; other site 1138871013702 catalytic residues [active] 1138871013703 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1138871013704 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1138871013705 PYR/PP interface [polypeptide binding]; other site 1138871013706 dimer interface [polypeptide binding]; other site 1138871013707 TPP binding site [chemical binding]; other site 1138871013708 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1138871013709 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1138871013710 TPP-binding site; other site 1138871013711 dimer interface [polypeptide binding]; other site 1138871013712 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138871013713 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138871013714 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871013715 NAD(P) binding site [chemical binding]; other site 1138871013716 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1138871013717 active site 1138871013718 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138871013719 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1138871013720 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1138871013721 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1138871013722 [2Fe-2S] cluster binding site [ion binding]; other site 1138871013723 C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882 1138871013724 putative alpha subunit interface [polypeptide binding]; other site 1138871013725 putative active site [active] 1138871013726 putative substrate binding site [chemical binding]; other site 1138871013727 Fe binding site [ion binding]; other site 1138871013728 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1138871013729 classical (c) SDRs; Region: SDR_c; cd05233 1138871013730 NAD(P) binding site [chemical binding]; other site 1138871013731 active site 1138871013732 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1138871013733 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1138871013734 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1138871013735 DNA-binding site [nucleotide binding]; DNA binding site 1138871013736 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1138871013737 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 1138871013738 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 1138871013739 acyl-activating enzyme (AAE) consensus motif; other site 1138871013740 putative AMP binding site [chemical binding]; other site 1138871013741 putative active site [active] 1138871013742 putative CoA binding site [chemical binding]; other site 1138871013743 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1138871013744 classical (c) SDRs; Region: SDR_c; cd05233 1138871013745 NAD(P) binding site [chemical binding]; other site 1138871013746 active site 1138871013747 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 1138871013748 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871013749 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1138871013750 acyl-activating enzyme (AAE) consensus motif; other site 1138871013751 acyl-activating enzyme (AAE) consensus motif; other site 1138871013752 putative AMP binding site [chemical binding]; other site 1138871013753 putative active site [active] 1138871013754 putative CoA binding site [chemical binding]; other site 1138871013755 oxidoreductase, Rxyl_3153 family; Region: Rxyl_3153; TIGR03989 1138871013756 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1138871013757 NAD binding site [chemical binding]; other site 1138871013758 catalytic Zn binding site [ion binding]; other site 1138871013759 substrate binding site [chemical binding]; other site 1138871013760 structural Zn binding site [ion binding]; other site 1138871013761 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1138871013762 hydrophobic ligand binding site; other site 1138871013763 SnoaL-like domain; Region: SnoaL_2; pfam12680 1138871013764 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 1138871013765 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1138871013766 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138871013767 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138871013768 DNA binding residues [nucleotide binding] 1138871013769 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1138871013770 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1138871013771 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1138871013772 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1138871013773 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1138871013774 motif II; other site 1138871013775 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1138871013776 acyl-CoA synthetase; Provisional; Region: PRK13383 1138871013777 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871013778 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871013779 AMP binding site [chemical binding]; other site 1138871013780 active site 1138871013781 acyl-activating enzyme (AAE) consensus motif; other site 1138871013782 CoA binding site [chemical binding]; other site 1138871013783 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1138871013784 classical (c) SDRs; Region: SDR_c; cd05233 1138871013785 NAD(P) binding site [chemical binding]; other site 1138871013786 active site 1138871013787 Cutinase; Region: Cutinase; pfam01083 1138871013788 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 1138871013789 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871013790 NAD(P) binding site [chemical binding]; other site 1138871013791 active site 1138871013792 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1138871013793 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871013794 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871013795 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138871013796 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1138871013797 cyclase homology domain; Region: CHD; cd07302 1138871013798 nucleotidyl binding site; other site 1138871013799 metal binding site [ion binding]; metal-binding site 1138871013800 dimer interface [polypeptide binding]; other site 1138871013801 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1138871013802 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871013803 S-adenosylmethionine binding site [chemical binding]; other site 1138871013804 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1138871013805 hydrophobic ligand binding site; other site 1138871013806 short chain dehydrogenase; Validated; Region: PRK08264 1138871013807 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871013808 NAD(P) binding site [chemical binding]; other site 1138871013809 active site 1138871013810 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1138871013811 CGNR zinc finger; Region: zf-CGNR; pfam11706 1138871013812 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1138871013813 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1138871013814 S-adenosylmethionine binding site [chemical binding]; other site 1138871013815 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871013816 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1138871013817 NAD(P) binding site [chemical binding]; other site 1138871013818 active site 1138871013819 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1138871013820 CoenzymeA binding site [chemical binding]; other site 1138871013821 subunit interaction site [polypeptide binding]; other site 1138871013822 PHB binding site; other site 1138871013823 Predicted membrane protein [Function unknown]; Region: COG3305 1138871013824 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 1138871013825 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1138871013826 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1138871013827 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH8; cd08262 1138871013828 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1138871013829 putative NAD(P) binding site [chemical binding]; other site 1138871013830 catalytic Zn binding site [ion binding]; other site 1138871013831 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1138871013832 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871013833 NAD(P) binding site [chemical binding]; other site 1138871013834 active site 1138871013835 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 1138871013836 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1138871013837 short chain dehydrogenase; Provisional; Region: PRK06940 1138871013838 classical (c) SDRs; Region: SDR_c; cd05233 1138871013839 NAD(P) binding site [chemical binding]; other site 1138871013840 active site 1138871013841 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1138871013842 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138871013843 Protein of unknown function, DUF417; Region: DUF417; cl01162 1138871013844 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1138871013845 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871013846 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1138871013847 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 1138871013848 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_7; cd07825 1138871013849 putative hydrophobic ligand binding site [chemical binding]; other site 1138871013850 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1138871013851 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1138871013852 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 1138871013853 putative dimerization interface [polypeptide binding]; other site 1138871013854 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1138871013855 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1138871013856 NAD(P) binding site [chemical binding]; other site 1138871013857 active site 1138871013858 oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971 1138871013859 classical (c) SDRs; Region: SDR_c; cd05233 1138871013860 NAD(P) binding site [chemical binding]; other site 1138871013861 active site 1138871013862 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1138871013863 classical (c) SDRs; Region: SDR_c; cd05233 1138871013864 NAD(P) binding site [chemical binding]; other site 1138871013865 active site 1138871013866 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1138871013867 metal-binding site [ion binding] 1138871013868 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1138871013869 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1138871013870 metal-binding site [ion binding] 1138871013871 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1138871013872 Predicted esterase [General function prediction only]; Region: COG0627 1138871013873 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1138871013874 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1138871013875 NodB motif; other site 1138871013876 active site 1138871013877 catalytic site [active] 1138871013878 metal binding site [ion binding]; metal-binding site 1138871013879 Secretory lipase; Region: LIP; pfam03583 1138871013880 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1138871013881 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 1138871013882 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871013883 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871013884 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871013885 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1138871013886 classical (c) SDRs; Region: SDR_c; cd05233 1138871013887 NAD(P) binding site [chemical binding]; other site 1138871013888 active site 1138871013889 acyl-CoA synthetase; Provisional; Region: PRK13388 1138871013890 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1138871013891 acyl-activating enzyme (AAE) consensus motif; other site 1138871013892 AMP binding site [chemical binding]; other site 1138871013893 active site 1138871013894 CoA binding site [chemical binding]; other site 1138871013895 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1138871013896 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1138871013897 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138871013898 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138871013899 active site 1138871013900 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138871013901 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138871013902 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1138871013903 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1138871013904 Amidohydrolase; Region: Amidohydro_2; pfam04909 1138871013905 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1138871013906 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1138871013907 DNA binding site [nucleotide binding] 1138871013908 domain linker motif; other site 1138871013909 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1138871013910 dimerization interface [polypeptide binding]; other site 1138871013911 ligand binding site [chemical binding]; other site 1138871013912 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1138871013913 DUF35 OB-fold domain; Region: DUF35; pfam01796 1138871013914 acetyl-CoA acetyltransferase; Provisional; Region: PRK08142 1138871013915 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1138871013916 active site 1138871013917 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871013918 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1138871013919 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871013920 active site 1138871013921 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1138871013922 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1138871013923 active site 1138871013924 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871013925 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871013926 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 1138871013927 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871013928 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 1138871013929 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 1138871013930 enolase; Provisional; Region: eno; PRK00077 1138871013931 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1138871013932 dimer interface [polypeptide binding]; other site 1138871013933 metal binding site [ion binding]; metal-binding site 1138871013934 substrate binding pocket [chemical binding]; other site 1138871013935 hydrogenase 4 subunit B; Validated; Region: PRK06521 1138871013936 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1138871013937 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 1138871013938 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329 1138871013939 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 1138871013940 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1138871013941 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1138871013942 Hydrogenase 4 membrane component (E) [Energy production and conversion]; Region: HyfE; cl17899 1138871013943 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1138871013944 NADH dehydrogenase; Region: NADHdh; cl00469 1138871013945 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1138871013946 nudix motif; other site 1138871013947 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 1138871013948 active site 1138871013949 metal binding site [ion binding]; metal-binding site 1138871013950 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1138871013951 Ligand Binding Site [chemical binding]; other site 1138871013952 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138871013953 Walker A/P-loop; other site 1138871013954 ATP binding site [chemical binding]; other site 1138871013955 Q-loop/lid; other site 1138871013956 ABC transporter signature motif; other site 1138871013957 Walker B; other site 1138871013958 D-loop; other site 1138871013959 H-loop/switch region; other site 1138871013960 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138871013961 Walker A/P-loop; other site 1138871013962 ATP binding site [chemical binding]; other site 1138871013963 Q-loop/lid; other site 1138871013964 ABC transporter signature motif; other site 1138871013965 Walker B; other site 1138871013966 D-loop; other site 1138871013967 H-loop/switch region; other site 1138871013968 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138871013969 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1138871013970 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 1138871013971 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1138871013972 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1138871013973 Walker A/P-loop; other site 1138871013974 ATP binding site [chemical binding]; other site 1138871013975 Q-loop/lid; other site 1138871013976 ABC transporter signature motif; other site 1138871013977 Walker B; other site 1138871013978 D-loop; other site 1138871013979 H-loop/switch region; other site 1138871013980 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1138871013981 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1138871013982 Walker A/P-loop; other site 1138871013983 ATP binding site [chemical binding]; other site 1138871013984 Q-loop/lid; other site 1138871013985 ABC transporter signature motif; other site 1138871013986 Walker B; other site 1138871013987 D-loop; other site 1138871013988 H-loop/switch region; other site 1138871013989 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1138871013990 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138871013991 Walker A/P-loop; other site 1138871013992 ATP binding site [chemical binding]; other site 1138871013993 Q-loop/lid; other site 1138871013994 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1138871013995 ABC transporter signature motif; other site 1138871013996 Walker B; other site 1138871013997 D-loop; other site 1138871013998 ABC transporter; Region: ABC_tran_2; pfam12848 1138871013999 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1138871014000 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG1888 1138871014001 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3787; cl17897 1138871014002 Homeodomain-like domain; Region: HTH_23; pfam13384 1138871014003 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1138871014004 Integrase core domain; Region: rve; pfam00665 1138871014005 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1138871014006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138871014007 Walker A motif; other site 1138871014008 ATP binding site [chemical binding]; other site 1138871014009 Walker B motif; other site 1138871014010 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1138871014011 active site 1138871014012 HIGH motif; other site 1138871014013 nucleotide binding site [chemical binding]; other site 1138871014014 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 1138871014015 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 1138871014016 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 1138871014017 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1138871014018 dimer interface [polypeptide binding]; other site 1138871014019 substrate binding site [chemical binding]; other site 1138871014020 metal binding sites [ion binding]; metal-binding site 1138871014021 nitrite reductase [NAD(P)H], large subunit; Region: nitri_red_nirB; TIGR02374 1138871014022 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1138871014023 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1138871014024 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1138871014025 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1138871014026 active site 1138871014027 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1138871014028 ligand-binding site [chemical binding]; other site 1138871014029 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1138871014030 sulfotransferase; Region: PLN02164 1138871014031 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871014032 PPE family; Region: PPE; pfam00823 1138871014033 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871014034 PPE family; Region: PPE; pfam00823 1138871014035 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138871014036 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1138871014037 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871014038 PPE family; Region: PPE; pfam00823 1138871014039 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871014040 PPE family; Region: PPE; pfam00823 1138871014041 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138871014042 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 1138871014043 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871014044 PPE family; Region: PPE; pfam00823 1138871014045 PPE-repeat proteins [Cell motility and secretion]; Region: COG5651 1138871014046 PPE family; Region: PPE; pfam00823 1138871014047 Polymorphic PE/PPE proteins C terminal; Region: PE_PPE_C; pfam12484 1138871014048 PE family; Region: PE; pfam00934 1138871014049 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1138871014050 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1138871014051 AAA domain; Region: AAA_23; pfam13476 1138871014052 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1138871014053 ABC transporter signature motif; other site 1138871014054 Walker B; other site 1138871014055 D-loop; other site 1138871014056 H-loop/switch region; other site 1138871014057 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1138871014058 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1138871014059 Walker A motif; other site 1138871014060 ATP binding site [chemical binding]; other site 1138871014061 Walker B motif; other site 1138871014062 Homeodomain-like domain; Region: HTH_23; pfam13384 1138871014063 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1138871014064 Integrase core domain; Region: rve; pfam00665 1138871014065 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 1138871014066 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 1138871014067 PII-like signaling protein [Signal transduction mechanisms]; Region: COG1993 1138871014068 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 1138871014069 Fructose-1.6-bisphosphate aldolase found in gram +/- bacteria; Region: FBP_aldolase_I_bact; cd00949 1138871014070 putative active site [active] 1138871014071 catalytic residue [active] 1138871014072 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1138871014073 anti sigma factor interaction site; other site 1138871014074 regulatory phosphorylation site [posttranslational modification]; other site 1138871014075 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1138871014076 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1138871014077 ATP binding site [chemical binding]; other site 1138871014078 Mg2+ binding site [ion binding]; other site 1138871014079 G-X-G motif; other site 1138871014080 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1138871014081 Phosphotransferase enzyme family; Region: APH; pfam01636 1138871014082 putative active site [active] 1138871014083 ATP binding site [chemical binding]; other site 1138871014084 putative substrate binding site [chemical binding]; other site 1138871014085 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1138871014086 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1138871014087 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1138871014088 Ecdysteroid kinase; Region: EcKinase; cl17738 1138871014089 Phosphotransferase enzyme family; Region: APH; pfam01636 1138871014090 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1138871014091 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 1138871014092 active site 1138871014093 putative substrate binding pocket [chemical binding]; other site 1138871014094 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1138871014095 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1138871014096 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1138871014097 [2Fe-2S] cluster binding site [ion binding]; other site 1138871014098 C-terminal catalytic domain of Pseudomonas fluorescens MupW and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_MupW-like; cd08882 1138871014099 putative alpha subunit interface [polypeptide binding]; other site 1138871014100 putative active site [active] 1138871014101 putative substrate binding site [chemical binding]; other site 1138871014102 Fe binding site [ion binding]; other site 1138871014103 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1138871014104 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1138871014105 active site 1138871014106 phosphorylation site [posttranslational modification] 1138871014107 intermolecular recognition site; other site 1138871014108 dimerization interface [polypeptide binding]; other site 1138871014109 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1138871014110 DNA binding residues [nucleotide binding] 1138871014111 dimerization interface [polypeptide binding]; other site 1138871014112 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1138871014113 Histidine kinase; Region: HisKA_3; pfam07730 1138871014114 Transport protein; Region: actII; TIGR00833 1138871014115 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 1138871014116 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138871014117 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 1138871014118 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138871014119 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1138871014120 Protein of unknown function (DUF690); Region: DUF690; pfam05108 1138871014121 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1138871014122 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1138871014123 catalytic residue [active] 1138871014124 conjugal transfer protein TrbL; Provisional; Region: PRK13875 1138871014125 Protein of unknown function (DUF2563); Region: DUF2563; pfam10817 1138871014126 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1138871014127 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1138871014128 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1138871014129 active site 1138871014130 NTP binding site [chemical binding]; other site 1138871014131 metal binding triad [ion binding]; metal-binding site 1138871014132 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1138871014133 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1138871014134 Zn2+ binding site [ion binding]; other site 1138871014135 Mg2+ binding site [ion binding]; other site 1138871014136 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1138871014137 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1138871014138 active site 1138871014139 Ap6A binding site [chemical binding]; other site 1138871014140 nudix motif; other site 1138871014141 metal binding site [ion binding]; metal-binding site 1138871014142 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1138871014143 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1138871014144 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 1138871014145 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1138871014146 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1138871014147 DNA binding residues [nucleotide binding] 1138871014148 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1138871014149 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1138871014150 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1138871014151 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1138871014152 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1138871014153 catalytic residues [active] 1138871014154 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1138871014155 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1138871014156 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1138871014157 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1138871014158 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1138871014159 active site 1138871014160 metal binding site [ion binding]; metal-binding site 1138871014161 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1138871014162 ParB-like nuclease domain; Region: ParBc; pfam02195 1138871014163 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1138871014164 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1138871014165 P-loop; other site 1138871014166 Magnesium ion binding site [ion binding]; other site 1138871014167 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1138871014168 Magnesium ion binding site [ion binding]; other site 1138871014169 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1138871014170 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 1138871014171 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1138871014172 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1138871014173 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1138871014174 G-X-X-G motif; other site 1138871014175 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1138871014176 RxxxH motif; other site 1138871014177 putative inner membrane protein translocase component YidC; Provisional; Region: PRK03449 1138871014178 Ribonuclease P; Region: Ribonuclease_P; cl00457