-- dump date 20140619_155719 -- class Genbank::misc_feature -- table misc_feature_note -- id note 2110000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 2110000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 2110000003 Walker A motif; other site 2110000004 ATP binding site [chemical binding]; other site 2110000005 Walker B motif; other site 2110000006 arginine finger; other site 2110000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 2110000008 DnaA box-binding interface [nucleotide binding]; other site 2110000009 DNA polymerase III subunit beta; Validated; Region: PRK05643 2110000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 2110000011 putative DNA binding surface [nucleotide binding]; other site 2110000012 dimer interface [polypeptide binding]; other site 2110000013 beta-clamp/clamp loader binding surface; other site 2110000014 beta-clamp/translesion DNA polymerase binding surface; other site 2110000015 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 2110000016 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 2110000017 nucleophilic elbow; other site 2110000018 catalytic triad; other site 2110000019 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 2110000020 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 2110000021 catalytic site [active] 2110000022 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 2110000023 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 2110000024 putative active site [active] 2110000025 putative FMN binding site [chemical binding]; other site 2110000026 putative substrate binding site [chemical binding]; other site 2110000027 putative catalytic residue [active] 2110000028 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 2110000029 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 2110000030 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 2110000031 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 2110000032 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 2110000033 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 2110000034 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 2110000035 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 2110000036 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 2110000037 lipoyl-biotinyl attachment site [posttranslational modification]; other site 2110000038 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 2110000039 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 2110000040 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 2110000041 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 2110000042 Walker A/P-loop; other site 2110000043 ATP binding site [chemical binding]; other site 2110000044 Q-loop/lid; other site 2110000045 ABC transporter signature motif; other site 2110000046 Walker B; other site 2110000047 D-loop; other site 2110000048 H-loop/switch region; other site 2110000049 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 2110000050 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 2110000051 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 2110000052 TM-ABC transporter signature motif; other site 2110000053 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 2110000054 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 2110000055 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 2110000056 TM-ABC transporter signature motif; other site 2110000057 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 2110000058 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 2110000059 active site 2110000060 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 2110000061 active site 2110000062 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 2110000063 Active site serine [active] 2110000064 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 2110000065 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 2110000066 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 2110000067 Integrase core domain; Region: rve; pfam00665 2110000068 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 2110000069 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 2110000070 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 2110000071 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 2110000072 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 2110000073 substrate binding site [chemical binding]; other site 2110000074 ATP binding site [chemical binding]; other site 2110000075 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 2110000076 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 2110000077 active site 2110000078 motif I; other site 2110000079 motif II; other site 2110000080 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 2110000081 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 2110000082 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 2110000083 Walker A/P-loop; other site 2110000084 ATP binding site [chemical binding]; other site 2110000085 Q-loop/lid; other site 2110000086 ABC transporter signature motif; other site 2110000087 Walker B; other site 2110000088 D-loop; other site 2110000089 H-loop/switch region; other site 2110000090 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14256 2110000091 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 2110000092 Walker A/P-loop; other site 2110000093 ATP binding site [chemical binding]; other site 2110000094 Q-loop/lid; other site 2110000095 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 2110000096 ABC transporter signature motif; other site 2110000097 Walker B; other site 2110000098 D-loop; other site 2110000099 H-loop/switch region; other site 2110000100 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 2110000101 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 2110000102 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 2110000103 Walker A/P-loop; other site 2110000104 ATP binding site [chemical binding]; other site 2110000105 Q-loop/lid; other site 2110000106 ABC transporter signature motif; other site 2110000107 Walker B; other site 2110000108 D-loop; other site 2110000109 H-loop/switch region; other site 2110000110 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 2110000111 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 2110000112 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 2110000113 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 2110000114 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 2110000115 dimer interface [polypeptide binding]; other site 2110000116 conserved gate region; other site 2110000117 putative PBP binding loops; other site 2110000118 ABC-ATPase subunit interface; other site 2110000119 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 2110000120 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 2110000121 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 2110000122 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 2110000123 Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: CysS; COG0215 2110000124 active site 2110000125 HIGH motif; other site 2110000126 nucleotide binding site [chemical binding]; other site 2110000127 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 2110000128 active site 2110000129 KMSKS motif; other site 2110000130 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 2110000131 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 2110000132 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 2110000133 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 2110000134 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 2110000135 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 2110000136 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 2110000137 putative homodimer interface [polypeptide binding]; other site 2110000138 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 2110000139 heterodimer interface [polypeptide binding]; other site 2110000140 homodimer interface [polypeptide binding]; other site 2110000141 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 2110000142 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 2110000143 putative nucleotide binding site [chemical binding]; other site 2110000144 uridine monophosphate binding site [chemical binding]; other site 2110000145 homohexameric interface [polypeptide binding]; other site 2110000146 ribosome recycling factor; Reviewed; Region: frr; PRK00083 2110000147 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 2110000148 hinge region; other site 2110000149 Competence protein; Region: Competence; cl00471 2110000150 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 2110000151 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 2110000152 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 2110000153 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 2110000154 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 2110000155 S-adenosylmethionine binding site [chemical binding]; other site 2110000156 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 2110000157 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 2110000158 active site 2110000159 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 2110000160 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 2110000161 trmE is a tRNA modification GTPase; Region: trmE; cd04164 2110000162 G1 box; other site 2110000163 GTP/Mg2+ binding site [chemical binding]; other site 2110000164 Switch I region; other site 2110000165 G2 box; other site 2110000166 Switch II region; other site 2110000167 G3 box; other site 2110000168 G4 box; other site 2110000169 G5 box; other site 2110000170 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 2110000171 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 2110000172 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 2110000173 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 2110000174 seryl-tRNA synthetase; Provisional; Region: PRK05431 2110000175 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 2110000176 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 2110000177 dimer interface [polypeptide binding]; other site 2110000178 active site 2110000179 motif 1; other site 2110000180 motif 2; other site 2110000181 motif 3; other site 2110000182 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 2110000183 active site 2110000184 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 2110000185 Ribonuclease P; Region: Ribonuclease_P; pfam00825 2110000186 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 2110000187 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02201 2110000188 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 2110000189 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 2110000190 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 2110000191 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 2110000192 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 2110000193 PGAP1-like protein; Region: PGAP1; pfam07819 2110000194 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 2110000195 asparagine synthetase AsnA; Provisional; Region: PRK05425 2110000196 motif 1; other site 2110000197 dimer interface [polypeptide binding]; other site 2110000198 active site 2110000199 motif 2; other site 2110000200 motif 3; other site 2110000201 DNA polymerase III PolC; Validated; Region: polC; PRK00448 2110000202 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 2110000203 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 2110000204 active site 2110000205 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 2110000206 active site 2110000207 catalytic site [active] 2110000208 substrate binding site [chemical binding]; other site 2110000209 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 2110000210 recombination factor protein RarA; Reviewed; Region: PRK13342 2110000211 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 2110000212 Walker A motif; other site 2110000213 ATP binding site [chemical binding]; other site 2110000214 Walker B motif; other site 2110000215 arginine finger; other site 2110000216 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 2110000217 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 2110000218 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 2110000219 dimer interface [polypeptide binding]; other site 2110000220 motif 1; other site 2110000221 active site 2110000222 motif 2; other site 2110000223 motif 3; other site 2110000224 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 2110000225 ligand binding site [chemical binding]; other site 2110000226 active site 2110000227 UGI interface [polypeptide binding]; other site 2110000228 catalytic site [active] 2110000229 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 2110000230 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 2110000231 putative tRNA-binding site [nucleotide binding]; other site 2110000232 B3/4 domain; Region: B3_4; pfam03483 2110000233 tRNA synthetase B5 domain; Region: B5; pfam03484 2110000234 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 2110000235 motif 1; other site 2110000236 dimer interface [polypeptide binding]; other site 2110000237 motif 2; other site 2110000238 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 2110000239 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 2110000240 dimer interface [polypeptide binding]; other site 2110000241 active site 2110000242 glycine-pyridoxal phosphate binding site [chemical binding]; other site 2110000243 folate binding site [chemical binding]; other site 2110000244 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 2110000245 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 2110000246 Aminotransferase class-V; Region: Aminotran_5; pfam00266 2110000247 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 2110000248 catalytic residue [active] 2110000249 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 2110000250 active site 2110000251 trimerization site [polypeptide binding]; other site 2110000252 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 2110000253 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 2110000254 active site 2110000255 DNA binding site [nucleotide binding] 2110000256 putative nicotinate-nucleotide adenylyltransferase; Validated; Region: nadD; PRK07152 2110000257 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 2110000258 active site 2110000259 (T/H)XGH motif; other site 2110000260 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 2110000261 Zn2+ binding site [ion binding]; other site 2110000262 Mg2+ binding site [ion binding]; other site 2110000263 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 2110000264 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 2110000265 RNA binding surface [nucleotide binding]; other site 2110000266 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 2110000267 active site 2110000268 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 2110000269 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 2110000270 intersubunit interface [polypeptide binding]; other site 2110000271 active site 2110000272 zinc binding site [ion binding]; other site 2110000273 Na+ binding site [ion binding]; other site 2110000274 Staphylococcal nuclease homologues; Region: SNc; smart00318 2110000275 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 2110000276 Catalytic site; other site 2110000277 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 2110000278 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 2110000279 23S rRNA interface [nucleotide binding]; other site 2110000280 L7/L12 interface [polypeptide binding]; other site 2110000281 putative thiostrepton binding site; other site 2110000282 L25 interface [polypeptide binding]; other site 2110000283 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 2110000284 mRNA/rRNA interface [nucleotide binding]; other site 2110000285 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 2110000286 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 2110000287 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 2110000288 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 2110000289 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 2110000290 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 2110000291 GTP/Mg2+ binding site [chemical binding]; other site 2110000292 G4 box; other site 2110000293 G5 box; other site 2110000294 G1 box; other site 2110000295 Switch I region; other site 2110000296 G2 box; other site 2110000297 G3 box; other site 2110000298 Switch II region; other site 2110000299 HPr kinase/phosphorylase; Provisional; Region: PRK05428 2110000300 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 2110000301 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 2110000302 Hpr binding site; other site 2110000303 active site 2110000304 homohexamer subunit interaction site [polypeptide binding]; other site 2110000305 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 2110000306 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 2110000307 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 2110000308 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 2110000309 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 2110000310 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 2110000311 tetramer interface [polypeptide binding]; other site 2110000312 TPP-binding site [chemical binding]; other site 2110000313 heterodimer interface [polypeptide binding]; other site 2110000314 phosphorylation loop region [posttranslational modification] 2110000315 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 2110000316 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 2110000317 alpha subunit interface [polypeptide binding]; other site 2110000318 TPP binding site [chemical binding]; other site 2110000319 heterodimer interface [polypeptide binding]; other site 2110000320 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 2110000321 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 2110000322 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 2110000323 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 2110000324 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 2110000325 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 2110000326 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 2110000327 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 2110000328 conserved cys residue [active] 2110000329 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 2110000330 Integrase core domain; Region: rve; pfam00665 2110000331 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 2110000332 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 2110000333 dimer interface [polypeptide binding]; other site 2110000334 conserved gate region; other site 2110000335 putative PBP binding loops; other site 2110000336 ABC-ATPase subunit interface; other site 2110000337 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 2110000338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 2110000339 dimer interface [polypeptide binding]; other site 2110000340 conserved gate region; other site 2110000341 putative PBP binding loops; other site 2110000342 ABC-ATPase subunit interface; other site 2110000343 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 2110000344 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 2110000345 Walker A/P-loop; other site 2110000346 ATP binding site [chemical binding]; other site 2110000347 Q-loop/lid; other site 2110000348 ABC transporter signature motif; other site 2110000349 Walker B; other site 2110000350 D-loop; other site 2110000351 H-loop/switch region; other site 2110000352 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 2110000353 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 2110000354 Walker A/P-loop; other site 2110000355 ATP binding site [chemical binding]; other site 2110000356 Q-loop/lid; other site 2110000357 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 2110000358 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 2110000359 ABC transporter signature motif; other site 2110000360 Walker B; other site 2110000361 D-loop; other site 2110000362 H-loop/switch region; other site 2110000363 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 2110000364 ribonuclease Y; Region: RNase_Y; TIGR03319 2110000365 Uncharacterized conserved protein [Function unknown]; Region: COG1284 2110000366 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 2110000367 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 2110000368 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 2110000369 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 2110000370 putative active site [active] 2110000371 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 2110000372 Walker A/P-loop; other site 2110000373 ATP binding site [chemical binding]; other site 2110000374 Q-loop/lid; other site 2110000375 ABC transporter signature motif; other site 2110000376 Walker B; other site 2110000377 D-loop; other site 2110000378 H-loop/switch region; other site 2110000379 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 2110000380 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 2110000381 active site 2110000382 catalytic motif [active] 2110000383 Zn binding site [ion binding]; other site 2110000384 GTPase Era; Reviewed; Region: era; PRK00089 2110000385 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 2110000386 G1 box; other site 2110000387 GTP/Mg2+ binding site [chemical binding]; other site 2110000388 Switch I region; other site 2110000389 G2 box; other site 2110000390 Switch II region; other site 2110000391 G3 box; other site 2110000392 G4 box; other site 2110000393 G5 box; other site 2110000394 KH domain; Region: KH_2; pfam07650 2110000395 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 2110000396 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 2110000397 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 2110000398 active site 2110000399 prolyl-tRNA synthetase; Provisional; Region: PRK08661 2110000400 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 2110000401 dimer interface [polypeptide binding]; other site 2110000402 motif 1; other site 2110000403 active site 2110000404 motif 2; other site 2110000405 motif 3; other site 2110000406 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 2110000407 anticodon binding site; other site 2110000408 zinc-binding site [ion binding]; other site 2110000409 Putative membrane peptidase family (DUF2324); Region: DUF2324; cl01810 2110000410 LemA family; Region: LemA; cl00742 2110000411 putative phosphoketolase; Provisional; Region: PRK05261 2110000412 XFP N-terminal domain; Region: XFP_N; pfam09364 2110000413 XFP C-terminal domain; Region: XFP_C; pfam09363 2110000414 oligoendopeptidase F; Region: pepF; TIGR00181 2110000415 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 2110000416 active site 2110000417 Zn binding site [ion binding]; other site 2110000418 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 2110000419 AAA domain; Region: AAA_21; pfam13304 2110000420 Walker A/P-loop; other site 2110000421 ATP binding site [chemical binding]; other site 2110000422 Q-loop/lid; other site 2110000423 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 2110000424 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 2110000425 ABC transporter signature motif; other site 2110000426 Walker B; other site 2110000427 D-loop; other site 2110000428 H-loop/switch region; other site 2110000429 TOBE domain; Region: TOBE_2; pfam08402 2110000430 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 2110000431 dimer interface [polypeptide binding]; other site 2110000432 conserved gate region; other site 2110000433 putative PBP binding loops; other site 2110000434 ABC-ATPase subunit interface; other site 2110000435 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 2110000436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 2110000437 dimer interface [polypeptide binding]; other site 2110000438 conserved gate region; other site 2110000439 putative PBP binding loops; other site 2110000440 ABC-ATPase subunit interface; other site 2110000441 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 2110000442 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 2110000443 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 2110000444 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 2110000445 Ligand Binding Site [chemical binding]; other site 2110000446 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 2110000447 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 2110000448 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 2110000449 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 2110000450 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 2110000451 active site 2110000452 HIGH motif; other site 2110000453 nucleotide binding site [chemical binding]; other site 2110000454 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 2110000455 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 2110000456 active site 2110000457 KMSKS motif; other site 2110000458 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 2110000459 tRNA binding surface [nucleotide binding]; other site 2110000460 anticodon binding site; other site 2110000461 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 2110000462 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 2110000463 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 2110000464 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 2110000465 homodimer interface [polypeptide binding]; other site 2110000466 NADP binding site [chemical binding]; other site 2110000467 substrate binding site [chemical binding]; other site 2110000468 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 2110000469 acetate kinase; Provisional; Region: PRK07157 2110000470 propionate/acetate kinase; Provisional; Region: PRK12379 2110000471 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK13964 2110000472 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 2110000473 active site 2110000474 nucleotide binding site [chemical binding]; other site 2110000475 HIGH motif; other site 2110000476 KMSKS motif; other site 2110000477 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 2110000478 G1 box; other site 2110000479 GTP/Mg2+ binding site [chemical binding]; other site 2110000480 Switch I region; other site 2110000481 G2 box; other site 2110000482 G3 box; other site 2110000483 Switch II region; other site 2110000484 G4 box; other site 2110000485 G5 box; other site 2110000486 pyruvate kinase; Provisional; Region: PRK05826 2110000487 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 2110000488 domain interfaces; other site 2110000489 active site 2110000490 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 2110000491 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 2110000492 nucleotide binding site [chemical binding]; other site 2110000493 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 2110000494 Glucose inhibited division protein A; Region: GIDA; pfam01134 2110000495 (R)-2-Hydroxyglutarate Dehydrogenase and related dehydrogenases, NAD-binding and catalytic domains; Region: HGDH_like; cd12184 2110000496 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 2110000497 putative homodimer interface [polypeptide binding]; other site 2110000498 putative ligand binding site [chemical binding]; other site 2110000499 putative NAD binding site [chemical binding]; other site 2110000500 catalytic site [active] 2110000501 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 2110000502 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 2110000503 DNA methylase; Region: N6_N4_Mtase; pfam01555 2110000504 DNA methylase; Region: N6_N4_Mtase; cl17433 2110000505 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 2110000506 DNA methylase; Region: N6_N4_Mtase; pfam01555 2110000507 DNA methylase; Region: N6_N4_Mtase; cl17433 2110000508 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 2110000509 Helix-turn-helix domain; Region: HTH_38; pfam13936 2110000510 Integrase core domain; Region: rve; pfam00665 2110000511 trigger factor; Region: tig; TIGR00115 2110000512 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 2110000513 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 2110000514 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 2110000515 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 2110000516 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 2110000517 Walker A/P-loop; other site 2110000518 ATP binding site [chemical binding]; other site 2110000519 Q-loop/lid; other site 2110000520 ABC transporter signature motif; other site 2110000521 Walker B; other site 2110000522 D-loop; other site 2110000523 H-loop/switch region; other site 2110000524 ABC-2 type transporter; Region: ABC2_membrane; cl17235 2110000525 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 2110000526 5'-3' exonuclease; Provisional; Region: PRK14976 2110000527 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 2110000528 active site 2110000529 metal binding site 1 [ion binding]; metal-binding site 2110000530 putative 5' ssDNA interaction site; other site 2110000531 metal binding site 3; metal-binding site 2110000532 metal binding site 2 [ion binding]; metal-binding site 2110000533 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 2110000534 putative DNA binding site [nucleotide binding]; other site 2110000535 putative metal binding site [ion binding]; other site 2110000536 DNA polymerase III DnaE; Validated; Region: dnaE; PRK07135 2110000537 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 2110000538 active site 2110000539 PHP Thumb interface [polypeptide binding]; other site 2110000540 mycoides cluster lipoprotein, LppA/P72 family; Region: Mycoplas_LppA; TIGR03490 2110000541 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 2110000542 active site 2110000543 catalytic residues [active] 2110000544 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 2110000545 catalytic residues [active] 2110000546 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 2110000547 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 2110000548 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 2110000549 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 2110000550 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 2110000551 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 2110000552 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 2110000553 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 2110000554 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 2110000555 S-adenosylmethionine binding site [chemical binding]; other site 2110000556 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 2110000557 active site 2110000558 catalytic residues [active] 2110000559 metal binding site [ion binding]; metal-binding site 2110000560 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit [DNA replication, recombination, and repair]; Region: GyrB; COG0187 2110000561 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 2110000562 Mg2+ binding site [ion binding]; other site 2110000563 G-X-G motif; other site 2110000564 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 2110000565 anchoring element; other site 2110000566 dimer interface [polypeptide binding]; other site 2110000567 ATP binding site [chemical binding]; other site 2110000568 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 2110000569 active site 2110000570 metal binding site [ion binding]; metal-binding site 2110000571 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 2110000572 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 2110000573 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 2110000574 CAP-like domain; other site 2110000575 active site 2110000576 primary dimer interface [polypeptide binding]; other site 2110000577 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 2110000578 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 2110000579 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 2110000580 active site 2110000581 motif I; other site 2110000582 motif II; other site 2110000583 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 2110000584 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 2110000585 RNA/DNA hybrid binding site [nucleotide binding]; other site 2110000586 active site 2110000587 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 2110000588 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 2110000589 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 2110000590 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 2110000591 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 2110000592 active site 2110000593 Endonuclease I; Region: Endonuclease_1; cl01003 2110000594 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 2110000595 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 2110000596 TPP-binding site [chemical binding]; other site 2110000597 dimer interface [polypeptide binding]; other site 2110000598 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 2110000599 PYR/PP interface [polypeptide binding]; other site 2110000600 dimer interface [polypeptide binding]; other site 2110000601 TPP binding site [chemical binding]; other site 2110000602 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 2110000603 inorganic pyrophosphatase; Provisional; Region: PRK02230 2110000604 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 2110000605 dimer interface [polypeptide binding]; other site 2110000606 substrate binding site [chemical binding]; other site 2110000607 metal binding sites [ion binding]; metal-binding site 2110000608 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 2110000609 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 2110000610 nucleotide binding site/active site [active] 2110000611 HIT family signature motif; other site 2110000612 catalytic residue [active] 2110000613 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 2110000614 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 2110000615 dimer interface [polypeptide binding]; other site 2110000616 catalytic triad [active] 2110000617 peroxidatic and resolving cysteines [active] 2110000618 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 2110000619 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 2110000620 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 2110000621 P loop; other site 2110000622 GTP binding site [chemical binding]; other site 2110000623 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 2110000624 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 2110000625 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 2110000626 active site 2110000627 HIGH motif; other site 2110000628 KMSKS motif; other site 2110000629 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 2110000630 tRNA binding surface [nucleotide binding]; other site 2110000631 anticodon binding site; other site 2110000632 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 2110000633 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 2110000634 S-adenosylmethionine binding site [chemical binding]; other site 2110000635 ribonuclease R; Region: RNase_R; TIGR02063 2110000636 RNB domain; Region: RNB; pfam00773 2110000637 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 2110000638 RNA binding site [nucleotide binding]; other site 2110000639 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 2110000640 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 2110000641 catalytic site [active] 2110000642 G-X2-G-X-G-K; other site 2110000643 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 2110000644 active site 2110000645 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 2110000646 Catalytic domain of Protein Kinases; Region: PKc; cd00180 2110000647 active site 2110000648 ATP binding site [chemical binding]; other site 2110000649 substrate binding site [chemical binding]; other site 2110000650 activation loop (A-loop); other site 2110000651 Predicted GTPases [General function prediction only]; Region: COG1162 2110000652 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 2110000653 RNA binding site [nucleotide binding]; other site 2110000654 homodimer interface [polypeptide binding]; other site 2110000655 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 2110000656 GTPase/Zn-binding domain interface [polypeptide binding]; other site 2110000657 GTP/Mg2+ binding site [chemical binding]; other site 2110000658 G4 box; other site 2110000659 G5 box; other site 2110000660 G1 box; other site 2110000661 Switch I region; other site 2110000662 G2 box; other site 2110000663 G3 box; other site 2110000664 Switch II region; other site 2110000665 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 2110000666 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 2110000667 substrate binding site [chemical binding]; other site 2110000668 hexamer interface [polypeptide binding]; other site 2110000669 metal binding site [ion binding]; metal-binding site 2110000670 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 2110000671 Integrase core domain; Region: rve; pfam00665 2110000672 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 2110000673 GIY-YIG motif/motif A; other site 2110000674 active site 2110000675 catalytic site [active] 2110000676 metal binding site [ion binding]; metal-binding site 2110000677 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 2110000678 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 2110000679 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 2110000680 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 2110000681 Walker A motif; other site 2110000682 ATP binding site [chemical binding]; other site 2110000683 Walker B motif; other site 2110000684 arginine finger; other site 2110000685 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 2110000686 active site 2110000687 catalytic triad [active] 2110000688 CTP synthetase; Validated; Region: pyrG; PRK05380 2110000689 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 2110000690 Catalytic site [active] 2110000691 active site 2110000692 UTP binding site [chemical binding]; other site 2110000693 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 2110000694 active site 2110000695 putative oxyanion hole; other site 2110000696 catalytic triad [active] 2110000697 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 2110000698 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 2110000699 active site 2110000700 HIGH motif; other site 2110000701 nucleotide binding site [chemical binding]; other site 2110000702 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 2110000703 active site 2110000704 KMSKS motif; other site 2110000705 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 2110000706 tRNA binding surface [nucleotide binding]; other site 2110000707 anticodon binding site; other site 2110000708 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 2110000709 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 2110000710 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 2110000711 RuvA N terminal domain; Region: RuvA_N; pfam01330 2110000712 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 2110000713 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 2110000714 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 2110000715 Walker A motif; other site 2110000716 ATP binding site [chemical binding]; other site 2110000717 Walker B motif; other site 2110000718 arginine finger; other site 2110000719 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 2110000720 Protein export membrane protein; Region: SecD_SecF; cl14618 2110000721 Protein export membrane protein; Region: SecD_SecF; cl14618 2110000722 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02193 2110000723 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 2110000724 RNA binding site [nucleotide binding]; other site 2110000725 active site 2110000726 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 2110000727 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 2110000728 active site 2110000729 motif I; other site 2110000730 motif II; other site 2110000731 hypothetical protein; Provisional; Region: PRK07143 2110000732 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 2110000733 active site 2110000734 nucleotide binding site [chemical binding]; other site 2110000735 HIGH motif; other site 2110000736 KMSKS motif; other site 2110000737 Riboflavin kinase; Region: Flavokinase; cl03312 2110000738 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 2110000739 16S/18S rRNA binding site [nucleotide binding]; other site 2110000740 S13e-L30e interaction site [polypeptide binding]; other site 2110000741 25S rRNA binding site [nucleotide binding]; other site 2110000742 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 2110000743 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 2110000744 nucleophilic elbow; other site 2110000745 catalytic triad; other site 2110000746 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 2110000747 Walker A/P-loop; other site 2110000748 ATP binding site [chemical binding]; other site 2110000749 Q-loop/lid; other site 2110000750 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 2110000751 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 2110000752 ABC transporter signature motif; other site 2110000753 Walker B; other site 2110000754 D-loop; other site 2110000755 H-loop/switch region; other site 2110000756 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 2110000757 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 2110000758 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 2110000759 DHH family; Region: DHH; pfam01368 2110000760 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 2110000761 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 2110000762 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 2110000763 replicative DNA helicase; Region: DnaB; TIGR00665 2110000764 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 2110000765 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 2110000766 Walker A motif; other site 2110000767 ATP binding site [chemical binding]; other site 2110000768 Walker B motif; other site 2110000769 DNA binding loops [nucleotide binding] 2110000770 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 2110000771 Domain of unknown function DUF21; Region: DUF21; pfam01595 2110000772 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 2110000773 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 2110000774 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 2110000775 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 2110000776 active site turn [active] 2110000777 phosphorylation site [posttranslational modification] 2110000778 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 2110000779 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 2110000780 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 2110000781 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 2110000782 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 2110000783 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 2110000784 RmuC family; Region: RmuC; pfam02646 2110000785 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 2110000786 Active site serine [active] 2110000787 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 2110000788 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 2110000789 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 2110000790 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 2110000791 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 2110000792 DNA topoisomerase 2-like protein; Provisional; Region: PTZ00108 2110000793 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 2110000794 DpnII restriction endonuclease; Region: DpnII; pfam04556 2110000795 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 2110000796 rRNA interaction site [nucleotide binding]; other site 2110000797 S8 interaction site; other site 2110000798 putative laminin-1 binding site; other site 2110000799 elongation factor Ts; Provisional; Region: tsf; PRK09377 2110000800 UBA/TS-N domain; Region: UBA; pfam00627 2110000801 Elongation factor TS; Region: EF_TS; pfam00889 2110000802 Elongation factor TS; Region: EF_TS; pfam00889 2110000803 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 2110000804 Active site serine [active] 2110000805 dUTPase; Region: dUTPase_2; pfam08761 2110000806 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 2110000807 active site 2110000808 homodimer interface [polypeptide binding]; other site 2110000809 metal binding site [ion binding]; metal-binding site 2110000810 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 2110000811 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 2110000812 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 2110000813 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 2110000814 Uncharacterized conserved protein [Function unknown]; Region: COG0327 2110000815 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 2110000816 RNA polymerase sigma factor; Provisional; Region: PRK05901 2110000817 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 2110000818 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 2110000819 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 2110000820 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 2110000821 DNA binding residues [nucleotide binding] 2110000822 CHC2 zinc finger; Region: zf-CHC2; cl17510 2110000823 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 2110000824 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 2110000825 active site 2110000826 metal binding site [ion binding]; metal-binding site 2110000827 interdomain interaction site; other site 2110000828 glycyl-tRNA synthetase; Provisional; Region: PRK04173 2110000829 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 2110000830 motif 1; other site 2110000831 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 2110000832 active site 2110000833 motif 2; other site 2110000834 motif 3; other site 2110000835 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 2110000836 anticodon binding site; other site 2110000837 ribonuclease E; Reviewed; Region: rne; PRK10811 2110000838 High affinity transport system protein p37; Region: Mycoplasma_p37; pfam06646 2110000839 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 2110000840 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 2110000841 Walker A/P-loop; other site 2110000842 ATP binding site [chemical binding]; other site 2110000843 Q-loop/lid; other site 2110000844 ABC transporter signature motif; other site 2110000845 Walker B; other site 2110000846 D-loop; other site 2110000847 H-loop/switch region; other site 2110000848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 2110000849 dimer interface [polypeptide binding]; other site 2110000850 conserved gate region; other site 2110000851 putative PBP binding loops; other site 2110000852 ABC-ATPase subunit interface; other site 2110000853 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 2110000854 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 2110000855 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12903 2110000856 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 2110000857 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 2110000858 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 2110000859 catalytic Zn binding site [ion binding]; other site 2110000860 structural Zn binding site [ion binding]; other site 2110000861 NAD(P) binding site [chemical binding]; other site 2110000862 DNA topoisomerase I; Validated; Region: PRK05582 2110000863 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 2110000864 active site 2110000865 interdomain interaction site; other site 2110000866 putative metal-binding site [ion binding]; other site 2110000867 nucleotide binding site [chemical binding]; other site 2110000868 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 2110000869 domain I; other site 2110000870 DNA binding groove [nucleotide binding] 2110000871 phosphate binding site [ion binding]; other site 2110000872 domain II; other site 2110000873 domain III; other site 2110000874 nucleotide binding site [chemical binding]; other site 2110000875 catalytic site [active] 2110000876 domain IV; other site 2110000877 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 2110000878 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 2110000879 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 2110000880 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 2110000881 dimer interface [polypeptide binding]; other site 2110000882 ssDNA binding site [nucleotide binding]; other site 2110000883 tetramer (dimer of dimers) interface [polypeptide binding]; other site 2110000884 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 2110000885 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 2110000886 phosphopentomutase; Provisional; Region: PRK05362 2110000887 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 2110000888 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 2110000889 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 2110000890 nucleotide binding pocket [chemical binding]; other site 2110000891 K-X-D-G motif; other site 2110000892 catalytic site [active] 2110000893 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 2110000894 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 2110000895 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 2110000896 Dimer interface [polypeptide binding]; other site 2110000897 BRCT sequence motif; other site 2110000898 Putative peptidase (DUF31); Region: DUF31; pfam01732 2110000899 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 2110000900 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 2110000901 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 2110000902 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 2110000903 AAA-like domain; Region: AAA_10; pfam12846 2110000904 Domain of unknown function DUF87; Region: DUF87; pfam01935 2110000905 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 2110000906 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 2110000907 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 2110000908 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 2110000909 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 2110000910 P-loop; other site 2110000911 Magnesium ion binding site [ion binding]; other site 2110000912 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 2110000913 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 2110000914 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 2110000915 P-loop; other site 2110000916 Magnesium ion binding site [ion binding]; other site 2110000917 Putative peptidase (DUF31); Region: DUF31; pfam01732 2110000918 Protein of unknown function (DUF2714); Region: DUF2714; pfam10896 2110000919 F0F1 ATP synthase subunit alpha; Validated; Region: PRK07165 2110000920 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 2110000921 Walker A motif; other site 2110000922 ATP binding site [chemical binding]; other site 2110000923 Walker B motif; other site 2110000924 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 2110000925 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 2110000926 alpha subunit interaction interface [polypeptide binding]; other site 2110000927 Walker A motif; other site 2110000928 ATP binding site [chemical binding]; other site 2110000929 Walker B motif; other site 2110000930 inhibitor binding site; inhibition site 2110000931 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 2110000932 Putative peptidase (DUF31); Region: DUF31; pfam01732 2110000933 EDD domain protein, DegV family; Region: DegV; TIGR00762 2110000934 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 2110000935 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 2110000936 Part of AAA domain; Region: AAA_19; pfam13245 2110000937 Family description; Region: UvrD_C_2; pfam13538 2110000938 S4 domain; Region: S4_2; cl17325 2110000939 active site 2110000940 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 2110000941 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 2110000942 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 2110000943 putative dimer interface [polypeptide binding]; other site 2110000944 putative anticodon binding site; other site 2110000945 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 2110000946 motif 1; other site 2110000947 dimer interface [polypeptide binding]; other site 2110000948 active site 2110000949 motif 2; other site 2110000950 motif 3; other site 2110000951 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 2110000952 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 2110000953 MgtE intracellular N domain; Region: MgtE_N; pfam03448 2110000954 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 2110000955 elongation factor P; Validated; Region: PRK00529 2110000956 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 2110000957 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 2110000958 RNA binding site [nucleotide binding]; other site 2110000959 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 2110000960 RNA binding site [nucleotide binding]; other site 2110000961 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 2110000962 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 2110000963 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 2110000964 Walker A/P-loop; other site 2110000965 ATP binding site [chemical binding]; other site 2110000966 Q-loop/lid; other site 2110000967 ABC transporter signature motif; other site 2110000968 Walker B; other site 2110000969 D-loop; other site 2110000970 H-loop/switch region; other site 2110000971 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 2110000972 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 2110000973 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 2110000974 Walker A/P-loop; other site 2110000975 ATP binding site [chemical binding]; other site 2110000976 Q-loop/lid; other site 2110000977 ABC transporter signature motif; other site 2110000978 Walker B; other site 2110000979 D-loop; other site 2110000980 H-loop/switch region; other site 2110000981 Putative peptidase (DUF31); Region: DUF31; pfam01732 2110000982 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 2110000983 SelR domain; Region: SelR; pfam01641 2110000984 methionine sulfoxide reductase B; Provisional; Region: PRK00222 2110000985 Smr domain; Region: Smr; pfam01713 2110000986 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 2110000987 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 2110000988 DNA binding site [nucleotide binding] 2110000989 catalytic residue [active] 2110000990 H2TH interface [polypeptide binding]; other site 2110000991 putative catalytic residues [active] 2110000992 turnover-facilitating residue; other site 2110000993 intercalation triad [nucleotide binding]; other site 2110000994 8OG recognition residue [nucleotide binding]; other site 2110000995 putative reading head residues; other site 2110000996 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 2110000997 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 2110000998 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 2110000999 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 2110001000 active site 2110001001 dimer interface [polypeptide binding]; other site 2110001002 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 2110001003 dimer interface [polypeptide binding]; other site 2110001004 active site 2110001005 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 2110001006 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 2110001007 RNA binding site [nucleotide binding]; other site 2110001008 enolase; Provisional; Region: eno; PRK00077 2110001009 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 2110001010 dimer interface [polypeptide binding]; other site 2110001011 metal binding site [ion binding]; metal-binding site 2110001012 substrate binding pocket [chemical binding]; other site 2110001013 elongation factor Tu; Reviewed; Region: PRK12736 2110001014 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 2110001015 G1 box; other site 2110001016 GEF interaction site [polypeptide binding]; other site 2110001017 GTP/Mg2+ binding site [chemical binding]; other site 2110001018 Switch I region; other site 2110001019 G2 box; other site 2110001020 G3 box; other site 2110001021 Switch II region; other site 2110001022 G4 box; other site 2110001023 G5 box; other site 2110001024 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 2110001025 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 2110001026 Antibiotic Binding Site [chemical binding]; other site 2110001027 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 2110001028 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 2110001029 UGMP family protein; Validated; Region: PRK09604 2110001030 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 2110001031 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 2110001032 active site turn [active] 2110001033 phosphorylation site [posttranslational modification] 2110001034 AAA domain; Region: AAA_14; pfam13173 2110001035 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 2110001036 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 2110001037 Integrase core domain; Region: rve; pfam00665 2110001038 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 2110001039 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 2110001040 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 2110001041 active site 2110001042 HIGH motif; other site 2110001043 dimer interface [polypeptide binding]; other site 2110001044 KMSKS motif; other site 2110001045 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 2110001046 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 2110001047 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 2110001048 active site 2110001049 dimer interface [polypeptide binding]; other site 2110001050 motif 1; other site 2110001051 motif 2; other site 2110001052 motif 3; other site 2110001053 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 2110001054 anticodon binding site; other site 2110001055 Mycoplasma P30 protein; Region: P30; pfam07390 2110001056 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3421 2110001057 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 2110001058 F0F1 ATP synthase subunit C; Provisional; Region: PRK13469 2110001059 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 2110001060 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 2110001061 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 2110001062 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 2110001063 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 2110001064 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 2110001065 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 2110001066 beta subunit interaction interface [polypeptide binding]; other site 2110001067 Walker A motif; other site 2110001068 ATP binding site [chemical binding]; other site 2110001069 Walker B motif; other site 2110001070 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 2110001071 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 2110001072 core domain interface [polypeptide binding]; other site 2110001073 delta subunit interface [polypeptide binding]; other site 2110001074 epsilon subunit interface [polypeptide binding]; other site 2110001075 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 2110001076 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 2110001077 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 2110001078 alpha subunit interaction interface [polypeptide binding]; other site 2110001079 Walker A motif; other site 2110001080 ATP binding site [chemical binding]; other site 2110001081 Walker B motif; other site 2110001082 inhibitor binding site; inhibition site 2110001083 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 2110001084 F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) [Energy production and conversion]; Region: AtpC; COG0355 2110001085 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 2110001086 gamma subunit interface [polypeptide binding]; other site 2110001087 epsilon subunit interface [polypeptide binding]; other site 2110001088 LBP interface [polypeptide binding]; other site 2110001089 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 2110001090 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 2110001091 cofactor binding site; other site 2110001092 DNA binding site [nucleotide binding] 2110001093 substrate interaction site [chemical binding]; other site 2110001094 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 2110001095 Integrase core domain; Region: rve; pfam00665 2110001096 Eco47II restriction endonuclease; Region: RE_Eco47II; pfam09553 2110001097 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 2110001098 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 2110001099 Integrase core domain; Region: rve; pfam00665 2110001100 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 2110001101 Walker A motif; other site 2110001102 ATP binding site [chemical binding]; other site 2110001103 membrane protein; Provisional; Region: PRK14418 2110001104 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 2110001105 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 2110001106 Walker A motif; other site 2110001107 ATP binding site [chemical binding]; other site 2110001108 Walker B motif; other site 2110001109 arginine finger; other site 2110001110 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 2110001111 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 2110001112 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 2110001113 HIGH motif; other site 2110001114 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 2110001115 active site 2110001116 KMSKS motif; other site 2110001117 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 2110001118 tRNA binding surface [nucleotide binding]; other site 2110001119 anticodon binding site; other site 2110001120 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 2110001121 active site 2110001122 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 2110001123 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 2110001124 dimer interface [polypeptide binding]; other site 2110001125 ssDNA binding site [nucleotide binding]; other site 2110001126 tetramer (dimer of dimers) interface [polypeptide binding]; other site 2110001127 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 2110001128 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 2110001129 active site 2110001130 Zn binding site [ion binding]; other site 2110001131 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 2110001132 RNA methyltransferase, RsmE family; Region: TIGR00046 2110001133 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 2110001134 lipoyl-biotinyl attachment site [posttranslational modification]; other site 2110001135 Fic/DOC family; Region: Fic; cl00960 2110001136 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 2110001137 nucleotide binding site [chemical binding]; other site 2110001138 SulA interaction site; other site 2110001139 MraW methylase family; Region: Methyltransf_5; cl17771 2110001140 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 2110001141 cell division protein MraZ; Reviewed; Region: PRK00326 2110001142 MraZ protein; Region: MraZ; pfam02381 2110001143 MraZ protein; Region: MraZ; pfam02381 2110001144 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 2110001145 TrkA-N domain; Region: TrkA_N; pfam02254 2110001146 TrkA-C domain; Region: TrkA_C; pfam02080 2110001147 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 2110001148 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 2110001149 phospholipid-translocating P-type ATPase, flippase; Region: ATPase-Plipid; TIGR01652 2110001150 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 2110001151 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 2110001152 cofactor binding site; other site 2110001153 DNA binding site [nucleotide binding] 2110001154 substrate interaction site [chemical binding]; other site 2110001155 Bsp6I restriction endonuclease; Region: RE_Bsp6I; pfam09504 2110001156 excinuclease ABC subunit B; Provisional; Region: PRK05298 2110001157 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 2110001158 ATP binding site [chemical binding]; other site 2110001159 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 2110001160 nucleotide binding region [chemical binding]; other site 2110001161 ATP-binding site [chemical binding]; other site 2110001162 Ultra-violet resistance protein B; Region: UvrB; pfam12344 2110001163 UvrB/uvrC motif; Region: UVR; pfam02151 2110001164 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 2110001165 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 2110001166 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 2110001167 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 2110001168 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 2110001169 Nuclease-related domain; Region: NERD; pfam08378 2110001170 Protein of unknown function DUF45; Region: DUF45; cl00636 2110001171 GTP-binding protein YchF; Reviewed; Region: PRK09601 2110001172 YchF GTPase; Region: YchF; cd01900 2110001173 G1 box; other site 2110001174 GTP/Mg2+ binding site [chemical binding]; other site 2110001175 Switch I region; other site 2110001176 G2 box; other site 2110001177 Switch II region; other site 2110001178 G3 box; other site 2110001179 G4 box; other site 2110001180 G5 box; other site 2110001181 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 2110001182 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 2110001183 active site 2110001184 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 2110001185 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 2110001186 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 2110001187 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 2110001188 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 2110001189 NAD(P) binding site [chemical binding]; other site 2110001190 active site 2110001191 Putative peptidase (DUF31); Region: DUF31; pfam01732 2110001192 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 2110001193 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 2110001194 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 2110001195 motif 1; other site 2110001196 active site 2110001197 motif 2; other site 2110001198 motif 3; other site 2110001199 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 2110001200 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 2110001201 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 2110001202 Ligand Binding Site [chemical binding]; other site 2110001203 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 2110001204 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 2110001205 DEAD-like helicases superfamily; Region: DEXDc; smart00487 2110001206 DEAD/DEAH box helicase; Region: DEAD; pfam00270 2110001207 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 2110001208 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 2110001209 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 2110001210 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 2110001211 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 2110001212 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 2110001213 NAD binding site [chemical binding]; other site 2110001214 substrate binding site [chemical binding]; other site 2110001215 catalytic Zn binding site [ion binding]; other site 2110001216 tetramer interface [polypeptide binding]; other site 2110001217 structural Zn binding site [ion binding]; other site 2110001218 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 2110001219 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 2110001220 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 2110001221 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 2110001222 NAD binding site [chemical binding]; other site 2110001223 substrate binding site [chemical binding]; other site 2110001224 catalytic Zn binding site [ion binding]; other site 2110001225 tetramer interface [polypeptide binding]; other site 2110001226 structural Zn binding site [ion binding]; other site 2110001227 DNA protecting protein DprA; Region: dprA; TIGR00732 2110001228 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 2110001229 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 2110001230 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 2110001231 active site 2110001232 motif I; other site 2110001233 motif II; other site 2110001234 Uncharacterized conserved protein [Function unknown]; Region: COG1284 2110001235 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 2110001236 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 2110001237 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 2110001238 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 2110001239 Walker A/P-loop; other site 2110001240 ATP binding site [chemical binding]; other site 2110001241 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 2110001242 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 2110001243 ABC transporter signature motif; other site 2110001244 Walker B; other site 2110001245 D-loop; other site 2110001246 H-loop/switch region; other site 2110001247 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 2110001248 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 2110001249 dimerization interface [polypeptide binding]; other site 2110001250 active site 2110001251 metal binding site [ion binding]; metal-binding site 2110001252 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 2110001253 dsRNA binding site [nucleotide binding]; other site 2110001254 putative phosphate acyltransferase; Provisional; Region: PRK05331 2110001255 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 2110001256 DAK2 domain; Region: Dak2; pfam02734 2110001257 Recombination protein O N terminal; Region: RecO_N; pfam11967 2110001258 DNA repair protein RecO; Region: reco; TIGR00613 2110001259 Recombination protein O C terminal; Region: RecO_C; pfam02565 2110001260 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 2110001261 DHH family; Region: DHH; pfam01368 2110001262 DHHA1 domain; Region: DHHA1; pfam02272 2110001263 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 2110001264 DHH family; Region: DHH; pfam01368 2110001265 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 2110001266 glycerol kinase; Provisional; Region: glpK; PRK00047 2110001267 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 2110001268 N- and C-terminal domain interface [polypeptide binding]; other site 2110001269 active site 2110001270 MgATP binding site [chemical binding]; other site 2110001271 catalytic site [active] 2110001272 metal binding site [ion binding]; metal-binding site 2110001273 glycerol binding site [chemical binding]; other site 2110001274 homotetramer interface [polypeptide binding]; other site 2110001275 homodimer interface [polypeptide binding]; other site 2110001276 FBP binding site [chemical binding]; other site 2110001277 protein IIAGlc interface [polypeptide binding]; other site 2110001278 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 2110001279 amphipathic channel; other site 2110001280 Asn-Pro-Ala signature motifs; other site 2110001281 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 2110001282 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 2110001283 dimer interface [polypeptide binding]; other site 2110001284 anticodon binding site; other site 2110001285 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 2110001286 homodimer interface [polypeptide binding]; other site 2110001287 motif 1; other site 2110001288 active site 2110001289 motif 2; other site 2110001290 GAD domain; Region: GAD; pfam02938 2110001291 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 2110001292 active site 2110001293 motif 3; other site 2110001294 histidyl-tRNA synthetase; Region: hisS; TIGR00442 2110001295 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 2110001296 dimer interface [polypeptide binding]; other site 2110001297 motif 1; other site 2110001298 active site 2110001299 motif 2; other site 2110001300 motif 3; other site 2110001301 Amino acid permease; Region: AA_permease_2; pfam13520 2110001302 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 2110001303 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 2110001304 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 2110001305 23S rRNA interface [nucleotide binding]; other site 2110001306 L3 interface [polypeptide binding]; other site 2110001307 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 2110001308 Cupin domain; Region: Cupin_2; cl17218 2110001309 UDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: GalU; COG1210 2110001310 active site 2110001311 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 2110001312 Integrase core domain; Region: rve; pfam00665 2110001313 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 2110001314 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 2110001315 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 2110001316 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 2110001317 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 2110001318 motif II; other site 2110001319 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 2110001320 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 2110001321 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 2110001322 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 2110001323 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 2110001324 AAA-like domain; Region: AAA_10; pfam12846 2110001325 Domain of unknown function DUF87; Region: DUF87; pfam01935 2110001326 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 2110001327 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 2110001328 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 2110001329 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 2110001330 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 2110001331 P-loop; other site 2110001332 Magnesium ion binding site [ion binding]; other site 2110001333 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 2110001334 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 2110001335 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 2110001336 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 2110001337 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 2110001338 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 2110001339 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 2110001340 Walker A/P-loop; other site 2110001341 ATP binding site [chemical binding]; other site 2110001342 Q-loop/lid; other site 2110001343 ABC transporter signature motif; other site 2110001344 Walker B; other site 2110001345 D-loop; other site 2110001346 H-loop/switch region; other site 2110001347 aromatic cluster surface protein; Region: aro_clust_Mycop; TIGR04313 2110001348 aromatic cluster surface protein; Region: aro_clust_Mycop; TIGR04313 2110001349 aromatic cluster surface protein; Region: aro_clust_Mycop; TIGR04313 2110001350 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 2110001351 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 2110001352 active site 2110001353 substrate binding site [chemical binding]; other site 2110001354 metal binding site [ion binding]; metal-binding site 2110001355 transcription antitermination factor NusB; Region: nusB; TIGR01951 2110001356 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 2110001357 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 2110001358 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 2110001359 dimerization domain swap beta strand [polypeptide binding]; other site 2110001360 regulatory protein interface [polypeptide binding]; other site 2110001361 active site 2110001362 regulatory phosphorylation site [posttranslational modification]; other site 2110001363 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 2110001364 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 2110001365 dimer interface [polypeptide binding]; other site 2110001366 conserved gate region; other site 2110001367 ABC-ATPase subunit interface; other site 2110001368 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 2110001369 hypothetical protein; Provisional; Region: PRK13671 2110001370 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 2110001371 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 2110001372 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 2110001373 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 2110001374 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 2110001375 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 2110001376 23S rRNA binding site [nucleotide binding]; other site 2110001377 L21 binding site [polypeptide binding]; other site 2110001378 L13 binding site [polypeptide binding]; other site 2110001379 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 2110001380 Part of AAA domain; Region: AAA_19; pfam13245 2110001381 AAA domain; Region: AAA_12; pfam13087 2110001382 ABC transporter C family member; Provisional; Region: PLN03130 2110001383 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 2110001384 Phosphotransferase enzyme family; Region: APH; pfam01636 2110001385 active site 2110001386 ATP binding site [chemical binding]; other site 2110001387 substrate binding site [chemical binding]; other site 2110001388 GTP-binding protein LepA; Provisional; Region: PRK05433 2110001389 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 2110001390 G1 box; other site 2110001391 putative GEF interaction site [polypeptide binding]; other site 2110001392 GTP/Mg2+ binding site [chemical binding]; other site 2110001393 Switch I region; other site 2110001394 G2 box; other site 2110001395 G3 box; other site 2110001396 Switch II region; other site 2110001397 G4 box; other site 2110001398 G5 box; other site 2110001399 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 2110001400 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 2110001401 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 2110001402 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 2110001403 active site 2110001404 substrate binding site [chemical binding]; other site 2110001405 ATP binding site [chemical binding]; other site 2110001406 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 2110001407 Phosphotransferase enzyme family; Region: APH; pfam01636 2110001408 active site 2110001409 ATP binding site [chemical binding]; other site 2110001410 substrate binding site [chemical binding]; other site 2110001411 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 2110001412 dimer interface [polypeptide binding]; other site 2110001413 FMN binding site [chemical binding]; other site 2110001414 NADPH bind site [chemical binding]; other site 2110001415 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 2110001416 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 2110001417 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 2110001418 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 2110001419 active site 2110001420 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 2110001421 Integrase core domain; Region: rve; pfam00665 2110001422 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 2110001423 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 2110001424 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 2110001425 active site 2110001426 HIGH motif; other site 2110001427 KMSK motif region; other site 2110001428 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 2110001429 tRNA binding surface [nucleotide binding]; other site 2110001430 anticodon binding site; other site 2110001431 Membrane transport protein; Region: Mem_trans; cl09117 2110001432 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 2110001433 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 2110001434 NAD(P) binding site [chemical binding]; other site 2110001435 LDH/MDH dimer interface [polypeptide binding]; other site 2110001436 substrate binding site [chemical binding]; other site 2110001437 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 2110001438 E3 interaction surface; other site 2110001439 lipoyl attachment site [posttranslational modification]; other site 2110001440 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 2110001441 Acetokinase family; Region: Acetate_kinase; cl17229 2110001442 propionate/acetate kinase; Provisional; Region: PRK12379 2110001443 Major Facilitator Superfamily; Region: MFS_1; pfam07690 2110001444 Mycoplasma MFS transporter; Region: MFS_Mycoplasma; pfam07672 2110001445 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 2110001446 endonuclease IV; Provisional; Region: PRK01060 2110001447 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 2110001448 AP (apurinic/apyrimidinic) site pocket; other site 2110001449 DNA interaction; other site 2110001450 Metal-binding active site; metal-binding site 2110001451 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 2110001452 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 2110001453 GIY-YIG motif/motif A; other site 2110001454 active site 2110001455 catalytic site [active] 2110001456 putative DNA binding site [nucleotide binding]; other site 2110001457 metal binding site [ion binding]; metal-binding site 2110001458 UvrB/uvrC motif; Region: UVR; pfam02151 2110001459 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 2110001460 Mycoplasma MG185/MG260 protein; Region: Lipoprotein_X; pfam03305 2110001461 Putative mycoplasma lipoprotein, C-terminal region; Region: Lipoprotein_10; pfam03202 2110001462 Staphylococcal nuclease homologues; Region: SNc; smart00318 2110001463 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 2110001464 Catalytic site; other site 2110001465 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 2110001466 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 2110001467 Walker A/P-loop; other site 2110001468 ATP binding site [chemical binding]; other site 2110001469 Q-loop/lid; other site 2110001470 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 2110001471 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 2110001472 ABC transporter signature motif; other site 2110001473 Walker B; other site 2110001474 D-loop; other site 2110001475 H-loop/switch region; other site 2110001476 TOBE domain; Region: TOBE_2; pfam08402 2110001477 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 2110001478 dimer interface [polypeptide binding]; other site 2110001479 conserved gate region; other site 2110001480 putative PBP binding loops; other site 2110001481 ABC-ATPase subunit interface; other site 2110001482 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 2110001483 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 2110001484 dimer interface [polypeptide binding]; other site 2110001485 conserved gate region; other site 2110001486 putative PBP binding loops; other site 2110001487 ABC-ATPase subunit interface; other site 2110001488 GTPase CgtA; Reviewed; Region: obgE; PRK12297 2110001489 GTP1/OBG; Region: GTP1_OBG; pfam01018 2110001490 Obg GTPase; Region: Obg; cd01898 2110001491 G1 box; other site 2110001492 GTP/Mg2+ binding site [chemical binding]; other site 2110001493 Switch I region; other site 2110001494 G2 box; other site 2110001495 G3 box; other site 2110001496 Switch II region; other site 2110001497 G4 box; other site 2110001498 G5 box; other site 2110001499 Obg family GTPase CgtA, C-terminal extension; Region: Obg_CgtA_exten; TIGR03595 2110001500 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 2110001501 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 2110001502 active site 2110001503 motif I; other site 2110001504 motif II; other site 2110001505 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 2110001506 Purine-nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: DeoD; COG0813 2110001507 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 2110001508 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 2110001509 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 2110001510 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 2110001511 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 2110001512 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 2110001513 intersubunit interface [polypeptide binding]; other site 2110001514 active site 2110001515 catalytic residue [active] 2110001516 triosephosphate isomerase; Provisional; Region: PRK14565 2110001517 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 2110001518 substrate binding site [chemical binding]; other site 2110001519 dimer interface [polypeptide binding]; other site 2110001520 catalytic triad [active] 2110001521 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 2110001522 Helix-turn-helix domain; Region: HTH_38; pfam13936 2110001523 Integrase core domain; Region: rve; pfam00665 2110001524 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 2110001525 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13651 2110001526 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 2110001527 Walker A/P-loop; other site 2110001528 ATP binding site [chemical binding]; other site 2110001529 Q-loop/lid; other site 2110001530 ABC transporter signature motif; other site 2110001531 Walker B; other site 2110001532 D-loop; other site 2110001533 H-loop/switch region; other site 2110001534 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13632 2110001535 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 2110001536 Walker A/P-loop; other site 2110001537 ATP binding site [chemical binding]; other site 2110001538 Q-loop/lid; other site 2110001539 ABC transporter signature motif; other site 2110001540 Walker B; other site 2110001541 D-loop; other site 2110001542 H-loop/switch region; other site 2110001543 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 2110001544 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 2110001545 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 2110001546 alphaNTD - beta interaction site [polypeptide binding]; other site 2110001547 alphaNTD homodimer interface [polypeptide binding]; other site 2110001548 alphaNTD - beta' interaction site [polypeptide binding]; other site 2110001549 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 2110001550 30S ribosomal protein S11; Validated; Region: PRK05309 2110001551 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 2110001552 30S ribosomal protein S13; Region: bact_S13; TIGR03631 2110001553 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 2110001554 rRNA binding site [nucleotide binding]; other site 2110001555 predicted 30S ribosome binding site; other site 2110001556 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 2110001557 active site 2110001558 adenylate kinase; Region: adk; TIGR01351 2110001559 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 2110001560 AMP-binding site [chemical binding]; other site 2110001561 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 2110001562 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 2110001563 SecY translocase; Region: SecY; pfam00344 2110001564 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 2110001565 Integrase core domain; Region: rve; pfam00665 2110001566 Herpesvirus transcription activation factor (transactivator); Region: Herpes_TAF50; pfam03326 2110001567 Herpesvirus transcription activation factor (transactivator); Region: Herpes_TAF50; pfam03326 2110001568 Oxoglutarate and iron-dependent oxygenase degradation C-term; Region: Ofd1_CTDD; pfam10637 2110001569 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 2110001570 active site 2110001571 catalytic residues [active] 2110001572 DNA binding site [nucleotide binding] 2110001573 Int/Topo IB signature motif; other site 2110001574 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 2110001575 Integrase core domain; Region: rve; pfam00665 2110001576 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 2110001577 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 2110001578 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 2110001579 active site 2110001580 motif I; other site 2110001581 motif II; other site 2110001582 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 2110001583 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 2110001584 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 2110001585 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 2110001586 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 2110001587 5S rRNA interface [nucleotide binding]; other site 2110001588 L27 interface [polypeptide binding]; other site 2110001589 23S rRNA interface [nucleotide binding]; other site 2110001590 L5 interface [polypeptide binding]; other site 2110001591 ribosomal protein L6, bacterial type; Region: L6_bact; TIGR03654 2110001592 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 2110001593 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 2110001594 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 2110001595 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 2110001596 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 2110001597 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 2110001598 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 2110001599 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 2110001600 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 2110001601 RNA binding site [nucleotide binding]; other site 2110001602 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 2110001603 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 2110001604 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 2110001605 23S rRNA interface [nucleotide binding]; other site 2110001606 putative translocon interaction site; other site 2110001607 signal recognition particle (SRP54) interaction site; other site 2110001608 L23 interface [polypeptide binding]; other site 2110001609 trigger factor interaction site; other site 2110001610 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 2110001611 23S rRNA interface [nucleotide binding]; other site 2110001612 5S rRNA interface [nucleotide binding]; other site 2110001613 putative antibiotic binding site [chemical binding]; other site 2110001614 L25 interface [polypeptide binding]; other site 2110001615 L27 interface [polypeptide binding]; other site 2110001616 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 2110001617 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 2110001618 G-X-X-G motif; other site 2110001619 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 2110001620 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 2110001621 putative translocon binding site; other site 2110001622 protein-rRNA interface [nucleotide binding]; other site 2110001623 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 2110001624 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 2110001625 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 2110001626 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 2110001627 50S ribosomal protein L23; Reviewed; Region: rplW; PRK12280 2110001628 50S ribosomal protein L4; Provisional; Region: rplD; PRK14907 2110001629 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 2110001630 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 2110001631 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 2110001632 IHF dimer interface [polypeptide binding]; other site 2110001633 IHF - DNA interface [nucleotide binding]; other site 2110001634 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 2110001635 RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468 2110001636 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 2110001637 hexamer interface [polypeptide binding]; other site 2110001638 Walker A motif; other site 2110001639 ATP binding site [chemical binding]; other site 2110001640 Walker B motif; other site 2110001641 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 2110001642 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 2110001643 putative active site [active] 2110001644 metal binding site [ion binding]; metal-binding site 2110001645 homodimer binding site [polypeptide binding]; other site 2110001646 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 2110001647 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 2110001648 oligomer interface [polypeptide binding]; other site 2110001649 active site 2110001650 metal binding site [ion binding]; metal-binding site 2110001651 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 2110001652 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 2110001653 active site 2110001654 uracil binding [chemical binding]; other site 2110001655 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 2110001656 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 2110001657 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 2110001658 GrpE; Region: GrpE; pfam01025 2110001659 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 2110001660 dimer interface [polypeptide binding]; other site 2110001661 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 2110001662 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 2110001663 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 2110001664 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 2110001665 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 2110001666 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 2110001667 RNA binding surface [nucleotide binding]; other site 2110001668 DNA gyrase subunit A; Validated; Region: PRK05560 2110001669 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 2110001670 CAP-like domain; other site 2110001671 active site 2110001672 primary dimer interface [polypeptide binding]; other site 2110001673 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 2110001674 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 2110001675 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 2110001676 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 2110001677 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 2110001678 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 2110001679 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 2110001680 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 2110001681 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 2110001682 HsdM N-terminal domain; Region: HsdM_N; pfam12161 2110001683 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 2110001684 Methyltransferase domain; Region: Methyltransf_26; pfam13659 2110001685 AAA domain; Region: AAA_14; pfam13173 2110001686 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 2110001687 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 2110001688 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 2110001689 Int/Topo IB signature motif; other site 2110001690 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 2110001691 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 2110001692 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 2110001693 ATP binding site [chemical binding]; other site 2110001694 putative Mg++ binding site [ion binding]; other site 2110001695 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 2110001696 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 2110001697 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 2110001698 HsdM N-terminal domain; Region: HsdM_N; pfam12161 2110001699 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 2110001700 Methyltransferase domain; Region: Methyltransf_26; pfam13659 2110001701 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 2110001702 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 2110001703 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 2110001704 Active site serine [active] 2110001705 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 2110001706 Active site serine [active] 2110001707 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 2110001708 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 2110001709 HIGH motif; other site 2110001710 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 2110001711 active site 2110001712 KMSKS motif; other site 2110001713 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 2110001714 S-adenosylmethionine synthetase; Validated; Region: PRK05250 2110001715 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 2110001716 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 2110001717 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 2110001718 signal recognition particle protein; Provisional; Region: PRK10867 2110001719 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 2110001720 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 2110001721 P loop; other site 2110001722 GTP binding site [chemical binding]; other site 2110001723 Signal peptide binding domain; Region: SRP_SPB; pfam02978 2110001724 Predicted acetyltransferase [General function prediction only]; Region: COG3393 2110001725 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 2110001726 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 2110001727 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 2110001728 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 2110001729 active site 2110001730 Phosphoglycerate kinase; Region: PGK; pfam00162 2110001731 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 2110001732 substrate binding site [chemical binding]; other site 2110001733 hinge regions; other site 2110001734 ADP binding site [chemical binding]; other site 2110001735 catalytic site [active] 2110001736 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 2110001737 interface (dimer of trimers) [polypeptide binding]; other site 2110001738 Substrate-binding/catalytic site; other site 2110001739 Zn-binding sites [ion binding]; other site 2110001740 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 2110001741 putative active site [active] 2110001742 putative catalytic site [active] 2110001743 putative Mg binding site IVb [ion binding]; other site 2110001744 putative phosphate binding site [ion binding]; other site 2110001745 putative DNA binding site [nucleotide binding]; other site 2110001746 putative Mg binding site IVa [ion binding]; other site 2110001747 Imelysin; Region: Peptidase_M75; cl09159 2110001748 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 2110001749 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 2110001750 putative active site [active] 2110001751 putative metal binding site [ion binding]; other site 2110001752 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 2110001753 elongation factor G; Reviewed; Region: PRK12739 2110001754 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 2110001755 G1 box; other site 2110001756 putative GEF interaction site [polypeptide binding]; other site 2110001757 GTP/Mg2+ binding site [chemical binding]; other site 2110001758 Switch I region; other site 2110001759 G2 box; other site 2110001760 G3 box; other site 2110001761 Switch II region; other site 2110001762 G4 box; other site 2110001763 G5 box; other site 2110001764 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 2110001765 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 2110001766 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 2110001767 30S ribosomal protein S7; Validated; Region: PRK05302 2110001768 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 2110001769 S17 interaction site [polypeptide binding]; other site 2110001770 S8 interaction site; other site 2110001771 16S rRNA interaction site [nucleotide binding]; other site 2110001772 streptomycin interaction site [chemical binding]; other site 2110001773 23S rRNA interaction site [nucleotide binding]; other site 2110001774 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 2110001775 trigger factor; Region: tig; TIGR00115 2110001776 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 2110001777 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 2110001778 Walker A/P-loop; other site 2110001779 ATP binding site [chemical binding]; other site 2110001780 Q-loop/lid; other site 2110001781 ABC transporter signature motif; other site 2110001782 Walker B; other site 2110001783 D-loop; other site 2110001784 H-loop/switch region; other site 2110001785 ABC transporter; Region: ABC_tran_2; pfam12848 2110001786 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 2110001787 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 2110001788 active site 2110001789 catalytic residues [active] 2110001790 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 2110001791 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 2110001792 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 2110001793 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 2110001794 Walker A/P-loop; other site 2110001795 ATP binding site [chemical binding]; other site 2110001796 Q-loop/lid; other site 2110001797 ABC transporter signature motif; other site 2110001798 Walker B; other site 2110001799 D-loop; other site 2110001800 H-loop/switch region; other site 2110001801 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 2110001802 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 2110001803 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 2110001804 Walker A/P-loop; other site 2110001805 ATP binding site [chemical binding]; other site 2110001806 Q-loop/lid; other site 2110001807 ABC transporter signature motif; other site 2110001808 Walker B; other site 2110001809 D-loop; other site 2110001810 H-loop/switch region; other site 2110001811 translation elongation factor P; Region: efp; TIGR00038 2110001812 AAA domain; Region: AAA_13; pfam13166 2110001813 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 2110001814 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 2110001815 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 2110001816 hypothetical protein; Provisional; Region: PRK00523 2110001817 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 2110001818 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 2110001819 oligomer interface [polypeptide binding]; other site 2110001820 active site 2110001821 metal binding site [ion binding]; metal-binding site 2110001822 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 2110001823 active site 2110001824 catalytic triad [active] 2110001825 oxyanion hole [active] 2110001826 YycH protein; Region: YycH; pfam07435 2110001827 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 2110001828 RNA polymerase beta' subunit; Region: rpoC1; CHL00018 2110001829 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 2110001830 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 2110001831 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 2110001832 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 2110001833 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 2110001834 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 2110001835 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 2110001836 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 2110001837 G-loop; other site 2110001838 DNA binding site [nucleotide binding] 2110001839 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 2110001840 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 2110001841 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 2110001842 RPB1 interaction site [polypeptide binding]; other site 2110001843 RPB10 interaction site [polypeptide binding]; other site 2110001844 RPB11 interaction site [polypeptide binding]; other site 2110001845 RPB3 interaction site [polypeptide binding]; other site 2110001846 RPB12 interaction site [polypeptide binding]; other site 2110001847 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 2110001848 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 2110001849 P-loop; other site 2110001850 Magnesium ion binding site [ion binding]; other site 2110001851 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 2110001852 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 2110001853 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 2110001854 P-loop; other site 2110001855 Magnesium ion binding site [ion binding]; other site 2110001856 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 2110001857 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 2110001858 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 2110001859 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 2110001860 AAA-like domain; Region: AAA_10; pfam12846 2110001861 Domain of unknown function DUF87; Region: DUF87; pfam01935 2110001862 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 2110001863 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 2110001864 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 2110001865 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 2110001866 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 2110001867 core dimer interface [polypeptide binding]; other site 2110001868 peripheral dimer interface [polypeptide binding]; other site 2110001869 L10 interface [polypeptide binding]; other site 2110001870 L11 interface [polypeptide binding]; other site 2110001871 putative EF-Tu interaction site [polypeptide binding]; other site 2110001872 putative EF-G interaction site [polypeptide binding]; other site 2110001873 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 2110001874 23S rRNA interface [nucleotide binding]; other site 2110001875 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 2110001876 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 2110001877 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 2110001878 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 2110001879 dimer interface [polypeptide binding]; other site 2110001880 putative anticodon binding site; other site 2110001881 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 2110001882 motif 1; other site 2110001883 active site 2110001884 motif 2; other site 2110001885 motif 3; other site 2110001886 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 2110001887 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 2110001888 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 2110001889 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 2110001890 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 2110001891 RNA binding site [nucleotide binding]; other site 2110001892 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 2110001893 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 2110001894 Walker A motif; other site 2110001895 ATP binding site [chemical binding]; other site 2110001896 Walker B motif; other site 2110001897 arginine finger; other site 2110001898 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 2110001899 Walker A motif; other site 2110001900 ATP binding site [chemical binding]; other site 2110001901 Walker B motif; other site 2110001902 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 2110001903 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 2110001904 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 2110001905 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 2110001906 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 2110001907 putative active site [active] 2110001908 substrate binding site [chemical binding]; other site 2110001909 putative cosubstrate binding site; other site 2110001910 catalytic site [active] 2110001911 Formyl transferase, C-terminal domain; Region: Formyl_trans_C; pfam02911 2110001912 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I; Region: PGM_PMM_I; pfam02878 2110001913 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 2110001914 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 2110001915 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 2110001916 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 2110001917 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 2110001918 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 2110001919 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 2110001920 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 2110001921 putative active site [active] 2110001922 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 2110001923 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 2110001924 intersubunit interface [polypeptide binding]; other site 2110001925 active site 2110001926 Zn2+ binding site [ion binding]; other site 2110001927 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 2110001928 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 2110001929 AP (apurinic/apyrimidinic) site pocket; other site 2110001930 DNA interaction; other site 2110001931 Metal-binding active site; metal-binding site 2110001932 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 2110001933 active site 2110001934 dimer interface [polypeptide binding]; other site 2110001935 magnesium binding site [ion binding]; other site 2110001936 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 2110001937 active site 2110001938 phosphorylation site [posttranslational modification] 2110001939 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 2110001940 active site 2110001941 P-loop; other site 2110001942 phosphorylation site [posttranslational modification] 2110001943 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 2110001944 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 2110001945 active site 2110001946 substrate binding pocket [chemical binding]; other site 2110001947 homodimer interaction site [polypeptide binding]; other site 2110001948 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 2110001949 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 2110001950 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 2110001951 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 2110001952 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 2110001953 Helix-turn-helix domain; Region: HTH_38; pfam13936 2110001954 Integrase core domain; Region: rve; pfam00665 2110001955 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 2110001956 Fic family protein [Function unknown]; Region: COG3177 2110001957 Fic/DOC family; Region: Fic; pfam02661 2110001958 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 2110001959 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 2110001960 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 2110001961 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 2110001962 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 2110001963 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 2110001964 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 2110001965 Walker A/P-loop; other site 2110001966 ATP binding site [chemical binding]; other site 2110001967 Q-loop/lid; other site 2110001968 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 2110001969 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 2110001970 ABC transporter signature motif; other site 2110001971 Walker B; other site 2110001972 D-loop; other site 2110001973 H-loop/switch region; other site 2110001974 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 2110001975 active site 2110001976 hypothetical protein; Validated; Region: PRK00110 2110001977 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 2110001978 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 2110001979 homodimer interface [polypeptide binding]; other site 2110001980 NAD binding pocket [chemical binding]; other site 2110001981 ATP binding pocket [chemical binding]; other site 2110001982 Mg binding site [ion binding]; other site 2110001983 active-site loop [active] 2110001984 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 2110001985 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 2110001986 TRAM domain; Region: TRAM; pfam01938 2110001987 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 2110001988 S-adenosylmethionine binding site [chemical binding]; other site 2110001989 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 2110001990 Walker A motif; other site 2110001991 ATP binding site [chemical binding]; other site 2110001992 Walker B motif; other site 2110001993 arginine finger; other site 2110001994 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 2110001995 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 2110001996 CoA-binding site [chemical binding]; other site 2110001997 ATP-binding [chemical binding]; other site 2110001998 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 2110001999 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 2110002000 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 2110002001 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 2110002002 M42 glutamyl aminopeptidase; Region: Peptidase_M42; cl17262 2110002003 asparagine synthetase A; Reviewed; Region: PRK06462 2110002004 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 2110002005 RNA/DNA hybrid binding site [nucleotide binding]; other site 2110002006 active site 2110002007 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 2110002008 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 2110002009 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 2110002010 RNA binding surface [nucleotide binding]; other site 2110002011 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 2110002012 active site 2110002013 Chromate transporter; Region: Chromate_transp; cl17781 2110002014 Chromate transporter; Region: Chromate_transp; pfam02417 2110002015 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 2110002016 S-adenosylmethionine binding site [chemical binding]; other site 2110002017 Protein of unknown function (DUF402); Region: DUF402; cl00979 2110002018 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 2110002019 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 2110002020 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 2110002021 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 2110002022 Predicted methyltransferases [General function prediction only]; Region: COG0313 2110002023 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 2110002024 putative SAM binding site [chemical binding]; other site 2110002025 putative homodimer interface [polypeptide binding]; other site 2110002026 DNA polymerase III subunit delta'; Validated; Region: PRK07132 2110002027 DNA polymerase III subunit delta'; Validated; Region: PRK08485 2110002028 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 2110002029 thymidylate kinase; Validated; Region: tmk; PRK00698 2110002030 TMP-binding site; other site 2110002031 ATP-binding site [chemical binding]; other site 2110002032 recombination protein RecR; Reviewed; Region: recR; PRK00076 2110002033 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 2110002034 active site 2110002035 metal binding site [ion binding]; metal-binding site 2110002036 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0718 2110002037 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 2110002038 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 2110002039 Walker A motif; other site 2110002040 ATP binding site [chemical binding]; other site 2110002041 Walker B motif; other site 2110002042 arginine finger; other site 2110002043 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 2110002044 phosphoglyceromutase; Provisional; Region: PRK05434 2110002045 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 2110002046 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 2110002047 active site 2110002048 motif I; other site 2110002049 motif II; other site 2110002050 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 2110002051 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 2110002052 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 2110002053 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 2110002054 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 2110002055 Integrase core domain; Region: rve; pfam00665 2110002056 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 2110002057 active site 2110002058 translation initiation factor IF-2; Region: IF-2; TIGR00487 2110002059 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 2110002060 G1 box; other site 2110002061 putative GEF interaction site [polypeptide binding]; other site 2110002062 GTP/Mg2+ binding site [chemical binding]; other site 2110002063 Switch I region; other site 2110002064 G2 box; other site 2110002065 G3 box; other site 2110002066 Switch II region; other site 2110002067 G4 box; other site 2110002068 G5 box; other site 2110002069 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 2110002070 Translation-initiation factor 2; Region: IF-2; pfam11987 2110002071 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 2110002072 Protein of unknown function (DUF448); Region: DUF448; pfam04296 2110002073 putative RNA binding cleft [nucleotide binding]; other site 2110002074 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 2110002075 NusA-like KH domain; Region: KH_5; pfam13184 2110002076 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 2110002077 G-X-X-G motif; other site 2110002078 hypothetical protein; Provisional; Region: PRK14644 2110002079 Sm and related proteins; Region: Sm_like; cl00259 2110002080 heptamer interface [polypeptide binding]; other site 2110002081 Sm1 motif; other site 2110002082 hexamer interface [polypeptide binding]; other site 2110002083 RNA binding site [nucleotide binding]; other site 2110002084 Sm2 motif; other site 2110002085 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 2110002086 thymidine kinase; Provisional; Region: PRK04296 2110002087 Walker A/P-loop; other site 2110002088 ATP binding site [chemical binding]; other site 2110002089 Q-loop/lid; other site 2110002090 ABC transporter signature motif; other site 2110002091 Walker B; other site 2110002092 D-loop; other site 2110002093 H-loop/switch region; other site 2110002094 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 2110002095 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 2110002096 interface (dimer of trimers) [polypeptide binding]; other site 2110002097 Substrate-binding/catalytic site; other site 2110002098 Zn-binding sites [ion binding]; other site 2110002099 hypothetical protein; Provisional; Region: PRK09609 2110002100 Oxoglutarate and iron-dependent oxygenase degradation C-term; Region: Ofd1_CTDD; pfam10637 2110002101 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 2110002102 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 2110002103 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 2110002104 Menin; Region: Menin; pfam05053 2110002105 Herpesvirus transcription activation factor (transactivator); Region: Herpes_TAF50; pfam03326 2110002106 Herpesvirus transcription activation factor (transactivator); Region: Herpes_TAF50; pfam03326 2110002107 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 2110002108 active site 2110002109 catalytic residues [active] 2110002110 DNA binding site [nucleotide binding] 2110002111 Int/Topo IB signature motif; other site 2110002112 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 2110002113 Integrase core domain; Region: rve; pfam00665 2110002114 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 2110002115 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 2110002116 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 2110002117 mycoides cluster lipoprotein, LppA/P72 family; Region: Mycoplas_LppA; TIGR03490 2110002118 Domain of unknown function(DUF2779); Region: DUF2779; pfam11074 2110002119 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 2110002120 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 2110002121 GatB domain; Region: GatB_Yqey; smart00845 2110002122 amidase; Provisional; Region: PRK07139 2110002123 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 2110002124 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 2110002125 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 2110002126 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 2110002127 RNA binding surface [nucleotide binding]; other site 2110002128 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 2110002129 active site 2110002130 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 2110002131 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 2110002132 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 2110002133 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 2110002134 putative acyl-acceptor binding pocket; other site 2110002135 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 2110002136 GTP-binding protein Der; Reviewed; Region: PRK00093 2110002137 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 2110002138 G1 box; other site 2110002139 GTP/Mg2+ binding site [chemical binding]; other site 2110002140 Switch I region; other site 2110002141 G2 box; other site 2110002142 Switch II region; other site 2110002143 G3 box; other site 2110002144 G4 box; other site 2110002145 G5 box; other site 2110002146 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 2110002147 G1 box; other site 2110002148 GTP/Mg2+ binding site [chemical binding]; other site 2110002149 Switch I region; other site 2110002150 G2 box; other site 2110002151 G3 box; other site 2110002152 Switch II region; other site 2110002153 G4 box; other site 2110002154 G5 box; other site 2110002155 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283 2110002156 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 2110002157 CMP-binding site; other site 2110002158 The sites determining sugar specificity; other site 2110002159 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 2110002160 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 2110002161 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 2110002162 HSP70 interaction site [polypeptide binding]; other site 2110002163 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 2110002164 Zn binding sites [ion binding]; other site 2110002165 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 2110002166 dimer interface [polypeptide binding]; other site 2110002167 Ribosome-binding factor A; Region: RBFA; pfam02033 2110002168 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 2110002169 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 2110002170 active site 2110002171 HIGH motif; other site 2110002172 dimer interface [polypeptide binding]; other site 2110002173 KMSKS motif; other site 2110002174 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 2110002175 putative tRNA-binding site [nucleotide binding]; other site 2110002176 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 2110002177 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 2110002178 acyl carrier protein; Provisional; Region: acpP; PRK00982 2110002179 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 2110002180 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 2110002181 S-adenosylmethionine binding site [chemical binding]; other site 2110002182 peptide chain release factor 1; Validated; Region: prfA; PRK00591 2110002183 This domain is found in peptide chain release factors; Region: PCRF; smart00937 2110002184 RF-1 domain; Region: RF-1; pfam00472 2110002185 Uncharacterized conserved protein [Function unknown]; Region: COG1284 2110002186 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 2110002187 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 2110002188 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 2110002189 ATP binding site [chemical binding]; other site 2110002190 Mg2+ binding site [ion binding]; other site 2110002191 G-X-G motif; other site 2110002192 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 2110002193 anchoring element; other site 2110002194 dimer interface [polypeptide binding]; other site 2110002195 ATP binding site [chemical binding]; other site 2110002196 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 2110002197 active site 2110002198 putative metal-binding site [ion binding]; other site 2110002199 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 2110002200 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 2110002201 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 2110002202 catalytic residues [active] 2110002203 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 2110002204 SmpB-tmRNA interface; other site 2110002205 Transcriptional regulators [Transcription]; Region: PurR; COG1609 2110002206 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 2110002207 DNA binding site [nucleotide binding] 2110002208 domain linker motif; other site 2110002209 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 2110002210 ligand binding site [chemical binding]; other site 2110002211 dimerization interface [polypeptide binding]; other site 2110002212 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 2110002213 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 2110002214 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 2110002215 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 2110002216 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 2110002217 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 2110002218 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 2110002219 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 2110002220 Walker A/P-loop; other site 2110002221 ATP binding site [chemical binding]; other site 2110002222 Q-loop/lid; other site 2110002223 ABC transporter signature motif; other site 2110002224 Walker B; other site 2110002225 D-loop; other site 2110002226 H-loop/switch region; other site 2110002227 FtsX-like permease family; Region: FtsX; pfam02687 2110002228 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 2110002229 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 2110002230 Walker A motif; other site 2110002231 ATP binding site [chemical binding]; other site 2110002232 Walker B motif; other site 2110002233 arginine finger; other site 2110002234 Peptidase family M41; Region: Peptidase_M41; pfam01434 2110002235 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 2110002236 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 2110002237 Ligand Binding Site [chemical binding]; other site 2110002238 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 2110002239 putative active site [active] 2110002240 catalytic residue [active] 2110002241 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 2110002242 AAA domain; Region: AAA_30; pfam13604 2110002243 Family description; Region: UvrD_C_2; pfam13538