-- dump date 20111121_013407 -- class Genbank::misc_feature -- table misc_feature_note -- id note 572263000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 572263000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 572263000003 Walker A motif; other site 572263000004 ATP binding site; other site 572263000005 Walker B motif; other site 572263000006 arginine finger; other site 572263000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 572263000008 DnaA box-binding interface; other site 572263000009 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140 572263000010 DNA polymerase III beta subunit; Region: POL3Bc; smart00480 572263000011 putative DNA binding surface; other site 572263000012 dimer interface; other site 572263000013 beta-clamp/clamp loader binding surface; other site 572263000014 beta-clamp/translesion DNA polymerase binding surface; other site 572263000015 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 572263000016 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 572263000017 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; cl11520 572263000018 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679 572263000019 DHH family; Region: DHH; pfam01368 572263000020 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 572263000021 DHH family; Region: DHH; pfam01368 572263000022 DHHA1 domain; Region: DHHA1; pfam02272 572263000023 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07187 572263000024 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 572263000025 Class I ribonucleotide reductase; Region: RNR_I; cd01679 572263000026 active site 572263000027 dimer interface; other site 572263000028 catalytic residues; other site 572263000029 effector binding site; other site 572263000030 R2 peptide binding site; other site 572263000031 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 572263000032 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 572263000033 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 572263000034 dimer interface; other site 572263000035 putative radical transfer pathway; other site 572263000036 diiron center; other site 572263000037 tyrosyl radical; other site 572263000038 Mycoplasma MG185/MG260 protein; Region: Lipoprotein_X; pfam03305 572263000039 Putative mycoplasma lipoprotein, C-terminal region; Region: Lipoprotein_10; pfam03202 572263000040 Mycoplasma MG185/MG260 protein; Region: Lipoprotein_X; pfam03305 572263000041 Putative mycoplasma lipoprotein, C-terminal region; Region: Lipoprotein_10; pfam03202 572263000042 Mycoplasma MG185/MG260 protein; Region: Lipoprotein_X; pfam03305 572263000043 Putative mycoplasma lipoprotein, C-terminal region; Region: Lipoprotein_10; pfam03202 572263000044 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 572263000045 Catalytic site; other site 572263000046 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 572263000047 Walker A/P-loop; other site 572263000048 ATP binding site; other site 572263000049 Q-loop/lid; other site 572263000050 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 572263000051 ABC transporter signature motif; other site 572263000052 Walker B; other site 572263000053 D-loop; other site 572263000054 H-loop/switch region; other site 572263000055 TOBE domain; Region: TOBE_2; cl01440 572263000056 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 572263000057 dimer interface; other site 572263000058 conserved gate region; other site 572263000059 putative PBP binding loops; other site 572263000060 ABC-ATPase subunit interface; other site 572263000061 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 572263000062 dimer interface; other site 572263000063 conserved gate region; other site 572263000064 putative PBP binding loops; other site 572263000065 ABC-ATPase subunit interface; other site 572263000066 FAD dependent oxidoreductase; Region: DAO; pfam01266 572263000067 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572263000068 glycerol kinase; Provisional; Region: glpK; PRK00047 572263000069 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; pfam00370 572263000070 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 572263000071 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-...; Region: MIP; cl00200 572263000072 amphipathic channel; other site 572263000073 Asn-Pro-Ala signature motifs; other site 572263000074 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 572263000075 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 572263000076 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 572263000077 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 572263000078 active site 572263000079 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 572263000080 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 572263000081 23S rRNA interface; other site 572263000082 L3 interface; other site 572263000083 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 572263000084 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 572263000085 excinuclease ABC subunit B; Provisional; Region: PRK05298 572263000086 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 572263000087 ATP binding site; other site 572263000088 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 572263000089 nucleotide binding region; other site 572263000090 ATP-binding site; other site 572263000091 Ultra-violet resistance protein B; Region: UvrB; pfam12344 572263000092 UvrB/uvrC motif; Region: UVR; pfam02151 572263000093 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 572263000094 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 572263000095 Walker A/P-loop; other site 572263000096 ATP binding site; other site 572263000097 Q-loop/lid; other site 572263000098 ABC transporter signature motif; other site 572263000099 Walker B; other site 572263000100 D-loop; other site 572263000101 H-loop/switch region; other site 572263000102 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 572263000103 S-adenosylmethionine binding site; other site 572263000104 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein...; Region: Peptidase_M17; cd00433 572263000105 interface (dimer of trimers); other site 572263000106 Substrate-binding/catalytic site; other site 572263000107 Zn-binding sites; other site 572263000108 High affinity transport system protein p37; Region: Mycoplasma_p37; pfam06646 572263000109 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 572263000110 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 572263000111 Walker A/P-loop; other site 572263000112 ATP binding site; other site 572263000113 Q-loop/lid; other site 572263000114 ABC transporter signature motif; other site 572263000115 Walker B; other site 572263000116 D-loop; other site 572263000117 H-loop/switch region; other site 572263000118 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 572263000119 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 572263000120 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 572263000121 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 572263000122 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 572263000123 dimerization interface; other site 572263000124 domain crossover interface; other site 572263000125 redox-dependent activation switch; other site 572263000126 Competence-damaged protein; Region: CinA; cl00666 572263000127 trigger factor; Provisional; Region: tig; PRK01490 572263000128 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 572263000129 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 572263000130 DNA gyrase subunit A; Validated; Region: PRK05560 572263000131 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 572263000132 CAP-like domain; other site 572263000133 active site 572263000134 primary dimer interface; other site 572263000135 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 572263000136 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 572263000137 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 572263000138 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 572263000139 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 572263000140 DNA gyrase, B subunit; Region: gyrB; TIGR01059 572263000141 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572263000142 ATP binding site; other site 572263000143 Mg2+ binding site; other site 572263000144 G-X-G motif; other site 572263000145 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 572263000146 anchoring element; other site 572263000147 dimer interface; other site 572263000148 ATP binding site; other site 572263000149 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 572263000150 active site 572263000151 putative metal-binding site; other site 572263000152 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 572263000153 LemA family; Region: LemA; cl00742 572263000154 prolyl-tRNA synthetase; Provisional; Region: PRK08661 572263000155 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_arch_euk; cd00778 572263000156 dimer interface; other site 572263000157 motif 1; other site 572263000158 active site 572263000159 motif 2; other site 572263000160 motif 3; other site 572263000161 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible...; Region: HGTP_anticodon; cl00266 572263000162 anticodon binding site; other site 572263000163 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 572263000164 catalytic residues; other site 572263000165 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 572263000166 TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain alpha-keto acid dehydrogenase/2-oxoisovalerate dehydrogenase complex...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 572263000167 tetramer interface; other site 572263000168 TPP-binding site; other site 572263000169 heterodimer interface; other site 572263000170 phosphorylation loop region 572263000171 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 572263000172 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 572263000173 alpha subunit interface; other site 572263000174 TPP binding site; other site 572263000175 heterodimer interface; other site 572263000176 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 572263000177 e3 binding domain; Region: E3_binding; pfam02817 572263000178 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 572263000179 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 572263000180 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 572263000181 E3 interaction surface; other site 572263000182 lipoyl attachment site; other site 572263000183 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 572263000184 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572263000185 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 572263000186 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 572263000187 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 572263000188 Walker A/P-loop; other site 572263000189 ATP binding site; other site 572263000190 Q-loop/lid; other site 572263000191 ABC transporter signature motif; other site 572263000192 Walker B; other site 572263000193 D-loop; other site 572263000194 H-loop/switch region; other site 572263000195 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 572263000196 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 572263000197 ABC transporter signature motif; other site 572263000198 Walker B; other site 572263000199 D-loop; other site 572263000200 H-loop/switch region; other site 572263000201 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 572263000202 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 572263000203 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 572263000204 Walker A motif; other site 572263000205 ATP binding site; other site 572263000206 Walker B motif; other site 572263000207 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 572263000208 arginine finger; other site 572263000209 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 572263000210 Walker A motif; other site 572263000211 ATP binding site; other site 572263000212 Walker B motif; other site 572263000213 arginine finger; other site 572263000214 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 572263000215 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 572263000216 substrate binding site; other site 572263000217 dimer interface; other site 572263000218 catalytic triad; other site 572263000219 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353 572263000220 16S/18S rRNA binding site; other site 572263000221 S13e-L30e interaction site; other site 572263000222 25S rRNA binding site; other site 572263000223 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 572263000224 putative nicotinate-nucleotide adenylyltransferase; Validated; Region: nadD; PRK07152 572263000225 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 572263000226 active site 572263000227 substrate binding site; other site 572263000228 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 572263000229 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 572263000230 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 572263000231 active site 572263000232 motif I; other site 572263000233 motif II; other site 572263000234 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 572263000235 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 572263000236 Acetokinase family; Region: Acetate_kinase; cl01029 572263000237 acetate kinase; Reviewed; Region: PRK12440 572263000238 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 572263000239 active site 572263000240 nucleotide binding site; other site 572263000241 HIGH motif; other site 572263000242 KMSKS motif; other site 572263000243 GTP-binding protein; Provisional; Region: PRK04213 572263000244 The YihA (EngB) subfamily. This subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control. YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and...; Region: YihA_EngB; cd01876 572263000245 G1 box; other site 572263000246 GTP/Mg2+ binding site; other site 572263000247 Switch I region; other site 572263000248 G2 box; other site 572263000249 G3 box; other site 572263000250 Switch II region; other site 572263000251 G4 box; other site 572263000252 G5 box; other site 572263000253 putative transposase OrfB; Reviewed; Region: PHA02517 572263000254 Integrase core domain; Region: rve; cl01316 572263000255 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 572263000256 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl11406 572263000257 NAD(P) binding site; other site 572263000258 LDH/MDH dimer interface; other site 572263000259 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 572263000260 substrate binding site; other site 572263000261 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 572263000262 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998 572263000263 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 572263000264 phosphate binding site; other site 572263000265 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 572263000266 active site 572263000267 phosphorylation site 572263000268 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 572263000269 ascorbate-specific PTS system enzyme IIC; Reviewed; Region: PRK12997 572263000270 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 572263000271 transketolase; Reviewed; Region: PRK05899 572263000272 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 572263000273 TPP-binding site; other site 572263000274 dimer interface; other site 572263000275 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 572263000276 PYR/PP interface; other site 572263000277 dimer interface; other site 572263000278 TPP binding site; other site 572263000279 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 572263000280 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 572263000281 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 572263000282 active site 572263000283 HIGH motif; other site 572263000284 dimer interface; other site 572263000285 KMSKS motif; other site 572263000286 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 572263000287 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 572263000288 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6...; Region: AP2Ec; cd00019 572263000289 AP (apurinic/apyrimidinic) site pocket; other site 572263000290 DNA interaction; other site 572263000291 Metal-binding active site; metal-binding site 572263000292 Uncharacterized conserved protein [Function unknown]; Region: COG0327 572263000293 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl01309 572263000294 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 572263000295 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 572263000296 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 572263000297 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 572263000298 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 572263000299 DNA primase, catalytic core; Region: dnaG; TIGR01391 572263000300 CHC2 zinc finger; Region: zf-CHC2; cl02597 572263000301 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 572263000302 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 572263000303 active site 572263000304 metal-binding site 572263000305 interdomain interaction site; other site 572263000306 glycyl-tRNA synthetase; Provisional; Region: PRK04173 572263000307 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 572263000308 motif 1; other site 572263000309 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the...; Region: GlyRS-like_core; cd00774 572263000310 motif 1; other site 572263000311 dimer interface; other site 572263000312 active site 572263000313 motif 2; other site 572263000314 motif 3; other site 572263000315 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 572263000316 anticodon binding site; other site 572263000317 signal recognition particle protein; Region: ffh; TIGR00959 572263000318 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 572263000319 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 572263000320 P loop; other site 572263000321 GTP binding site; other site 572263000322 Signal peptide binding domain; Region: SRP_SPB; pfam02978 572263000323 elongation factor Ts; Provisional; Region: tsf; PRK09377 572263000324 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 572263000325 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 572263000326 rRNA interaction site; other site 572263000327 S8 interaction site; other site 572263000328 putative laminin-1 binding site; other site 572263000329 Recombination protein U; Region: RecU; cl01314 572263000330 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 572263000331 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 572263000332 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 572263000333 putative acyl-acceptor binding pocket; other site 572263000334 ScpA/B protein; Region: ScpA_ScpB; cl00598 572263000335 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 572263000336 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 572263000337 putative DNA-binding/iron metalloprotein/AP endonuclease; Reviewed; Region: PRK09604 572263000338 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 572263000339 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 572263000340 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 572263000341 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 572263000342 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 572263000343 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 572263000344 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 572263000345 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 572263000346 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 572263000347 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 572263000348 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 572263000349 putative translocon binding site; other site 572263000350 protein-rRNA interface; other site 572263000351 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 572263000352 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The...; Region: 30S_S3_KH; cd02412 572263000353 G-X-X-G motif; other site 572263000354 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 572263000355 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 572263000356 23S rRNA interface; other site 572263000357 5S rRNA interface; other site 572263000358 putative antibiotic binding site; other site 572263000359 L25 interface; other site 572263000360 L27 interface; other site 572263000361 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cl09943 572263000362 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 572263000363 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 572263000364 KOW motif; Region: KOW; cl00354 572263000365 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 572263000366 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 572263000367 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 572263000368 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 572263000369 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 572263000370 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 572263000371 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 572263000372 5S rRNA interface; other site 572263000373 23S rRNA interface; other site 572263000374 L5 interface; other site 572263000375 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 572263000376 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 572263000377 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 572263000378 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 572263000379 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 572263000380 eubacterial secY protein; Region: SecY; pfam00344 572263000381 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 572263000382 adenylate kinases; Region: adk; TIGR01351 572263000383 AMP-binding site; other site 572263000384 ATP-AMP (Ap5A)-binding site; other site 572263000385 methionine aminopeptidase; Reviewed; Region: PRK07281 572263000386 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 572263000387 active site 572263000388 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 572263000389 rRNA binding site; other site 572263000390 predicted 30S ribosome binding site; other site 572263000391 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 572263000392 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 572263000393 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 572263000394 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 572263000395 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 572263000396 alphaNTD homodimer interface; other site 572263000397 alphaNTD - beta interaction site; other site 572263000398 alphaNTD - beta' interaction site; other site 572263000399 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 572263000400 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 572263000401 Endonuclease/Exonuclease/phosphatase family; Region: Exo_endo_phos; cl00490 572263000402 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 572263000403 HrcA protein C terminal domain; Region: HrcA; pfam01628 572263000404 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446 572263000405 dimer interface; other site 572263000406 hsp70 (ATPase domain) interactions; other site 572263000407 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 572263000408 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 572263000409 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 572263000410 active site 572263000411 HIGH motif; other site 572263000412 KMSK motif region; other site 572263000413 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 572263000414 tRNA binding surface; other site 572263000415 anticodon binding site; other site 572263000416 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 572263000417 tagatose-bisphosphate aldolase; Reviewed; Region: gatY; PRK09195 572263000418 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947 572263000419 intersubunit interface; other site 572263000420 active site 572263000421 zinc binding site; other site 572263000422 Na+ binding site; other site 572263000423 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 572263000424 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 572263000425 active site 572263000426 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 572263000427 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 572263000428 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 572263000429 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 572263000430 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 572263000431 GatB domain; Region: GatB_Yqey; cl11497 572263000432 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 572263000433 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 572263000434 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 572263000435 HIGH motif; other site 572263000436 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 572263000437 KMSKS motif; other site 572263000438 active site 572263000439 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 572263000440 tRNA binding surface; other site 572263000441 anticodon binding site; other site 572263000442 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 572263000443 DHH family; Region: DHH; pfam01368 572263000444 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 572263000445 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 572263000446 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 572263000447 replicative DNA helicase; Region: DnaB; TIGR00665 572263000448 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 572263000449 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 572263000450 Walker A motif; other site 572263000451 ATP binding site; other site 572263000452 Walker B motif; other site 572263000453 DNA binding loops 572263000454 Domain of unknown function DUF21; Region: DUF21; pfam01595 572263000455 FOG: CBS domain [General function prediction only]; Region: COG0517 572263000456 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 572263000457 Protein of unknown function DUF45; Region: DUF45; cl00636 572263000458 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 572263000459 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 572263000460 HIGH motif; other site 572263000461 active site 572263000462 nucleotide binding site; other site 572263000463 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 572263000464 KMSKS motif; other site 572263000465 active site 572263000466 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 572263000467 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 572263000468 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 572263000469 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 572263000470 DNA binding residues 572263000471 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 572263000472 Transcription termination factor nusG; Region: NusG; cl02766 572263000473 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 572263000474 type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746 572263000475 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 572263000476 N-acetylmuramoyl-L-alanine amidase; Validated; Region: PRK08581 572263000477 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 572263000478 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 572263000479 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 572263000480 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 572263000481 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 572263000482 Peptidase dimerization domain; Region: M20_dimer; cl09126 572263000483 pyruvate kinase; Provisional; Region: PRK05826 572263000484 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl10032 572263000485 domain interfaces; other site 572263000486 active site 572263000487 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 572263000488 dimerization domain swap beta strand; other site 572263000489 regulatory protein interface; other site 572263000490 active site 572263000491 regulatory phosphorylation site; other site 572263000492 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 572263000493 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 572263000494 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 572263000495 active site turn 572263000496 phosphorylation site 572263000497 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cl00162 572263000498 HPr interaction site; other site 572263000499 glycerol kinase (GK) interaction site; other site 572263000500 active site 572263000501 phosphorylation site 572263000502 Uncharacterized conserved protein [Function unknown]; Region: COG1284 572263000503 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 572263000504 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 572263000505 S17 interaction site; other site 572263000506 S8 interaction site; other site 572263000507 16S rRNA interaction site; other site 572263000508 streptomycin interaction site; other site 572263000509 23S rRNA interaction site; other site 572263000510 aminoacyl-tRNA interaction site (A-site); other site 572263000511 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 572263000512 elongation factor G; Reviewed; Region: PRK12739 572263000513 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 572263000514 G1 box; other site 572263000515 putative GEF interaction site; other site 572263000516 GTP/Mg2+ binding site; other site 572263000517 Switch I region; other site 572263000518 G2 box; other site 572263000519 G3 box; other site 572263000520 Switch II region; other site 572263000521 G4 box; other site 572263000522 G5 box; other site 572263000523 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 572263000524 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 572263000525 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 572263000526 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 572263000527 Integrase core domain; Region: rve; cl01316 572263000528 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 572263000529 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 572263000530 DEAD-like helicases superfamily; Region: DEXDc; smart00487 572263000531 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl12029 572263000532 ATP binding site; other site 572263000533 putative Mg++ binding site; other site 572263000534 mycoides cluster lipoprotein, LppA/P72 family; Region: Mycoplas_LppA; TIGR03490 572263000535 cytidylate kinase; Provisional; Region: cmk; PRK00023 572263000536 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 572263000537 CMP-binding site; other site 572263000538 The sites determining sugar specificity; other site 572263000539 GTP-binding protein EngA; Reviewed; Region: engA; PRK00093 572263000540 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894 572263000541 G1 box; other site 572263000542 GTP/Mg2+ binding site; other site 572263000543 Switch I region; other site 572263000544 G2 box; other site 572263000545 Switch II region; other site 572263000546 G3 box; other site 572263000547 G4 box; other site 572263000548 G5 box; other site 572263000549 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895 572263000550 G1 box; other site 572263000551 GTP/Mg2+ binding site; other site 572263000552 Switch I region; other site 572263000553 G2 box; other site 572263000554 G3 box; other site 572263000555 Switch II region; other site 572263000556 G4 box; other site 572263000557 G5 box; other site 572263000558 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher...; Region: HU_IHF; cd00591 572263000559 IHF - DNA interface; other site 572263000560 IHF dimer interface; other site 572263000561 GTP-binding protein LepA; Provisional; Region: PRK05433 572263000562 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 572263000563 G1 box; other site 572263000564 putative GEF interaction site; other site 572263000565 GTP/Mg2+ binding site; other site 572263000566 Switch I region; other site 572263000567 G2 box; other site 572263000568 G3 box; other site 572263000569 Switch II region; other site 572263000570 G4 box; other site 572263000571 G5 box; other site 572263000572 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-...; Region: lepA_II; cd03699 572263000573 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 572263000574 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 572263000575 Cupin domain; Region: Cupin_2; cl09118 572263000576 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 572263000577 dimer interface; other site 572263000578 conserved gate region; other site 572263000579 putative PBP binding loops; other site 572263000580 ABC-ATPase subunit interface; other site 572263000581 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 572263000582 dimer interface; other site 572263000583 conserved gate region; other site 572263000584 putative PBP binding loops; other site 572263000585 ABC-ATPase subunit interface; other site 572263000586 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 572263000587 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 572263000588 Walker A/P-loop; other site 572263000589 ATP binding site; other site 572263000590 Q-loop/lid; other site 572263000591 ABC transporter signature motif; other site 572263000592 Walker B; other site 572263000593 D-loop; other site 572263000594 H-loop/switch region; other site 572263000595 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 572263000596 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 572263000597 Walker A/P-loop; other site 572263000598 ATP binding site; other site 572263000599 Q-loop/lid; other site 572263000600 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 572263000601 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 572263000602 ABC transporter signature motif; other site 572263000603 Walker B; other site 572263000604 D-loop; other site 572263000605 H-loop/switch region; other site 572263000606 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 572263000607 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 572263000608 active site 572263000609 substrate binding site; other site 572263000610 ATP binding site; other site 572263000611 activation loop (A-loop); other site 572263000612 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 572263000613 active site 572263000614 zinc binding site; other site 572263000615 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 572263000616 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with...; Region: ABCC_MRP_Like; cd03228 572263000617 Walker A/P-loop; other site 572263000618 ATP binding site; other site 572263000619 Q-loop/lid; other site 572263000620 ABC transporter signature motif; other site 572263000621 Walker B; other site 572263000622 D-loop; other site 572263000623 H-loop/switch region; other site 572263000624 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 572263000625 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 572263000626 Walker A/P-loop; other site 572263000627 ATP binding site; other site 572263000628 Q-loop/lid; other site 572263000629 ABC transporter signature motif; other site 572263000630 Walker B; other site 572263000631 D-loop; other site 572263000632 H-loop/switch region; other site 572263000633 SelR domain; Region: SelR; cl00369 572263000634 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 572263000635 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 572263000636 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 572263000637 RNA binding surface; other site 572263000638 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 572263000639 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 572263000640 P loop; other site 572263000641 GTP binding site; other site 572263000642 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 572263000643 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 572263000644 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 572263000645 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 572263000646 catalytic residues; other site 572263000647 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 572263000648 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 572263000649 DNA helicase, putative; Region: TIGR00376 572263000650 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl12029 572263000651 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 572263000652 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 572263000653 putative active site; other site 572263000654 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 572263000655 active site 572263000656 dimer interface; other site 572263000657 magnesium binding site; other site 572263000658 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 572263000659 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cl12060 572263000660 AP (apurinic/apyrimidinic) site pocket; other site 572263000661 DNA interaction; other site 572263000662 Metal-binding active site; metal-binding site 572263000663 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 572263000664 intersubunit interface; other site 572263000665 active site 572263000666 Zn2+ binding site; other site 572263000667 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 572263000668 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 572263000669 active site 572263000670 motif I; other site 572263000671 motif II; other site 572263000672 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 572263000673 bacterial/archael PhosphatidylEthanolamine-Binding Protein (PEBP) and its eukarytic homolog Raf Kinase Inhibitor Protein (RKIP) belong to a highly conserved family of phospholipid-binding proteins represented in all three major phylogenetic divisions (...; Region: PEBP_RKIP; cl00227 572263000674 substrate binding site; other site 572263000675 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403 572263000676 mRNA/rRNA interface; other site 572263000677 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 572263000678 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 572263000679 23S rRNA interface; other site 572263000680 L7/L12 interface; other site 572263000681 putative thiostrepton binding site; other site 572263000682 L25 interface; other site 572263000683 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 572263000684 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (...; Region: EcAsnRS_like_N; cd04318 572263000685 putative dimer interface; other site 572263000686 putative anticodon binding site; other site 572263000687 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well...; Region: AsxRS_core; cd00776 572263000688 homodimer interface; other site 572263000689 motif 1; other site 572263000690 motif 2; other site 572263000691 active site 572263000692 motif 3; other site 572263000693 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 572263000694 UvrD/REP helicase; Region: UvrD-helicase; cl14126 572263000695 UvrD/REP helicase; Region: UvrD-helicase; cl14126 572263000696 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 572263000697 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 572263000698 RuvA N terminal domain; Region: RuvA_N; pfam01330 572263000699 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 572263000700 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 572263000701 Walker A motif; other site 572263000702 ATP binding site; other site 572263000703 Walker B motif; other site 572263000704 arginine finger; other site 572263000705 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 572263000706 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 572263000707 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 572263000708 active site 572263000709 catalytic site; other site 572263000710 Major Facilitator Superfamily; Region: MFS_1; pfam07690 572263000711 GTP-binding protein Era; Reviewed; Region: era; PRK00089 572263000712 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163 572263000713 G1 box; other site 572263000714 GTP/Mg2+ binding site; other site 572263000715 Switch I region; other site 572263000716 G2 box; other site 572263000717 Switch II region; other site 572263000718 G3 box; other site 572263000719 G4 box; other site 572263000720 G5 box; other site 572263000721 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 572263000722 active site 572263000723 catalytic motif; other site 572263000724 Zn binding site; other site 572263000725 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 572263000726 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 572263000727 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various...; Region: Peptidase_C39E; cd02424 572263000728 putative active site; other site 572263000729 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 572263000730 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 572263000731 Walker A/P-loop; other site 572263000732 ATP binding site; other site 572263000733 Q-loop/lid; other site 572263000734 ABC transporter signature motif; other site 572263000735 Walker B; other site 572263000736 D-loop; other site 572263000737 H-loop/switch region; other site 572263000738 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl12023 572263000739 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 572263000740 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223 572263000741 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 572263000742 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 572263000743 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 572263000744 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 572263000745 pyridoxal 5'-phosphate binding pocket; other site 572263000746 catalytic residue; other site 572263000747 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 572263000748 trimerization site; other site 572263000749 active site 572263000750 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 572263000751 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 572263000752 RNA binding surface; other site 572263000753 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 572263000754 active site 572263000755 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cl00198 572263000756 substrate binding site; other site 572263000757 hinge regions; other site 572263000758 ADP binding site; other site 572263000759 catalytic site; other site 572263000760 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 572263000761 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 572263000762 MgtE intracellular N domain; Region: MgtE_N; pfam03448 572263000763 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 572263000764 Divalent cation transporter; Region: MgtE; cl00786 572263000765 cell division protein MraZ; Reviewed; Region: PRK00326 572263000766 MraZ protein; Region: MraZ; pfam02381 572263000767 MraZ protein; Region: MraZ; pfam02381 572263000768 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 572263000769 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 572263000770 nucleotide binding site; other site 572263000771 Domain of unknown function(DUF2779); Region: DUF2779; pfam11074 572263000772 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 572263000773 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572263000774 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 572263000775 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 572263000776 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 572263000777 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673 572263000778 motif 1; other site 572263000779 active site 572263000780 motif 2; other site 572263000781 motif 3; other site 572263000782 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 572263000783 Uncharacterized protein family (UPF0081); Region: UPF0081; cl00525 572263000784 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 572263000785 putative active site; other site 572263000786 catalytic residue; other site 572263000787 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 572263000788 Ligand Binding Site; other site 572263000789 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 572263000790 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 572263000791 Walker B motif; other site 572263000792 arginine finger; other site 572263000793 Peptidase family M41; Region: Peptidase_M41; pfam01434 572263000794 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 572263000795 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322 572263000796 dimer interface; other site 572263000797 putative anticodon binding site; other site 572263000798 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 572263000799 motif 1; other site 572263000800 active site 572263000801 motif 2; other site 572263000802 motif 3; other site 572263000803 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 572263000804 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 572263000805 active site 572263000806 motif I; other site 572263000807 motif II; other site 572263000808 elongation factor P; Validated; Region: PRK00529 572263000809 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 572263000810 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470 572263000811 RNA binding site; other site 572263000812 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794 572263000813 RNA binding site; other site 572263000814 transketolase; Reviewed; Region: PRK05899 572263000815 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 572263000816 TPP-binding site; other site 572263000817 dimer interface; other site 572263000818 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 572263000819 PYR/PP interface; other site 572263000820 dimer interface; other site 572263000821 TPP binding site; other site 572263000822 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 572263000823 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 572263000824 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 572263000825 active site 572263000826 HIGH motif; other site 572263000827 KMSKS motif; other site 572263000828 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 572263000829 tRNA binding surface; other site 572263000830 anticodon binding site; other site 572263000831 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 572263000832 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 572263000833 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 572263000834 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl12019 572263000835 active site 572263000836 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 572263000837 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 572263000838 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 572263000839 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 572263000840 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 572263000841 Walker A/P-loop; other site 572263000842 ATP binding site; other site 572263000843 Q-loop/lid; other site 572263000844 ABC transporter signature motif; other site 572263000845 Walker B; other site 572263000846 D-loop; other site 572263000847 H-loop/switch region; other site 572263000848 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: Php; COG1735 572263000849 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active...; Region: PTE; cd00530 572263000850 active site 572263000851 substrate binding pocket; other site 572263000852 homodimer interaction site; other site 572263000853 ascorbate-specific PTS system enzyme IIC; Reviewed; Region: PRK12997 572263000854 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 572263000855 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 572263000856 P-loop; other site 572263000857 active site 572263000858 phosphorylation site 572263000859 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 572263000860 active site 572263000861 phosphorylation site 572263000862 Protein of unknown function (DUF402); Region: DUF402; cl00979 572263000863 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 572263000864 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593 572263000865 dimerization interface; other site 572263000866 active site 572263000867 metal-binding site 572263000868 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048 572263000869 dsRNA binding site; other site 572263000870 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 572263000871 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 572263000872 DAK2 domain; Region: Dak2; cl03685 572263000873 Protein of unknown function (DUF2714); Region: DUF2714; pfam10896 572263000874 F0F1 ATP synthase subunit alpha; Validated; Region: PRK07165 572263000875 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 572263000876 Walker A motif; other site 572263000877 ATP binding site; other site 572263000878 Walker B motif; other site 572263000879 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 572263000880 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 572263000881 alpha subunit interaction interface; other site 572263000882 Walker A motif; other site 572263000883 ATP binding site; other site 572263000884 Walker B motif; other site 572263000885 inhibitor binding site; inhibition site 572263000886 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 572263000887 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 572263000888 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 572263000889 Walker A motif; other site 572263000890 ATP binding site; other site 572263000891 Walker B motif; other site 572263000892 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 572263000893 dimer interface; other site 572263000894 ssDNA binding site; other site 572263000895 tetramer (dimer of dimers) interface; other site 572263000896 type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746 572263000897 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 572263000898 replicative DNA helicase; Region: DnaB; TIGR00665 572263000899 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 572263000900 Walker A motif; other site 572263000901 ATP binding site; other site 572263000902 Walker B motif; other site 572263000903 DNA binding loops 572263000904 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 572263000905 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 572263000906 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 572263000907 P-loop; other site 572263000908 Magnesium ion binding site; other site 572263000909 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 572263000910 Magnesium ion binding site; other site 572263000911 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 572263000912 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 572263000913 putative active site; other site 572263000914 metal-binding site 572263000915 homodimer binding site; other site 572263000916 S-adenosylmethionine synthetase; Validated; Region: PRK05250 572263000917 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 572263000918 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 572263000919 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 572263000920 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 572263000921 DNA polymerase III subunit delta'; Validated; Region: PRK07132 572263000922 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 572263000923 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672 572263000924 thymidylate kinase; Validated; Region: tmk; PRK00698 572263000925 TMP-binding site; other site 572263000926 ATP-binding site; other site 572263000927 recombination protein RecR; Reviewed; Region: recR; PRK00076 572263000928 RecR protein; Region: RecR; pfam02132 572263000929 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 572263000930 active site 572263000931 metal-binding site 572263000932 Uncharacterized BCR, YbaB family COG0718; Region: DUF149; cl00494 572263000933 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07133 572263000934 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 572263000935 Walker A motif; other site 572263000936 ATP binding site; other site 572263000937 Walker B motif; other site 572263000938 arginine finger; other site 572263000939 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 572263000940 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 572263000941 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 572263000942 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 572263000943 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 572263000944 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 572263000945 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 572263000946 conserved cys residue; other site 572263000947 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 572263000948 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 572263000949 active site 572263000950 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and deoxyribose-1...; Region: PGM2; cd05799 572263000951 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 572263000952 active site 572263000953 substrate binding site; other site 572263000954 metal-binding site 572263000955 seryl-tRNA synthetase; Provisional; Region: PRK05431 572263000956 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 572263000957 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 572263000958 dimer interface; other site 572263000959 active site 572263000960 motif 1; other site 572263000961 motif 2; other site 572263000962 motif 3; other site 572263000963 phosphopyruvate hydratase; Provisional; Region: eno; PRK00077 572263000964 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 572263000965 dimer interface; other site 572263000966 metal-binding site 572263000967 substrate binding pocket; other site 572263000968 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 572263000969 active site 572263000970 catalytic triad; other site 572263000971 oxyanion hole; other site 572263000972 putative transposase OrfB; Reviewed; Region: PHA02517 572263000973 Integrase core domain; Region: rve; cl01316 572263000974 formamidopyrimidine-DNA glycosylase; Validated; Region: PRK01103 572263000975 Formamidopyrimidine-DNA glycosylase N-terminal domain; Region: Fapy_DNA_glyco; pfam01149 572263000976 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 572263000977 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 572263000978 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 572263000979 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 572263000980 PEP-utilising enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 572263000981 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 572263000982 Malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate cycle, which allows certain organisms, like plants and fungi, to derive their...; Region: malate_synt; cl09155 572263000983 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 572263000984 potential frameshift: common BLAST hit: gi|161870103|ref|YP_001599273.1| putative type I restriction enzyme 572263000985 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 572263000986 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl01057 572263000987 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl12029 572263000988 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 572263000989 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 572263000990 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 572263000991 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 572263000992 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 572263000993 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 572263000994 DNA binding site 572263000995 Int/Topo IB signature motif; other site 572263000996 active site 572263000997 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 572263000998 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 572263000999 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L...; Region: GCS_H; cd06848 572263001000 lipoyl attachment site; other site 572263001001 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+...; Region: SIR2; cl00195 572263001002 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 572263001003 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 572263001004 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 572263001005 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 572263001006 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 572263001007 putative active site; other site 572263001008 putative FMN binding site; other site 572263001009 putative substrate binding site; other site 572263001010 putative catalytic residue; other site 572263001011 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 572263001012 transcription termination factor Rho; Provisional; Region: rho; PRK09376 572263001013 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 572263001014 dimer interface; other site 572263001015 conserved gate region; other site 572263001016 putative PBP binding loops; other site 572263001017 ABC-ATPase subunit interface; other site 572263001018 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 572263001019 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 572263001020 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 572263001021 Walker A/P-loop; other site 572263001022 ATP binding site; other site 572263001023 Q-loop/lid; other site 572263001024 ABC transporter signature motif; other site 572263001025 Walker B; other site 572263001026 D-loop; other site 572263001027 H-loop/switch region; other site 572263001028 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 572263001029 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 572263001030 Walker A/P-loop; other site 572263001031 ATP binding site; other site 572263001032 Q-loop/lid; other site 572263001033 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 572263001034 ABC transporter signature motif; other site 572263001035 Walker B; other site 572263001036 D-loop; other site 572263001037 H-loop/switch region; other site 572263001038 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 572263001039 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 572263001040 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 572263001041 oligoendopeptidase F; Region: pepF; TIGR00181 572263001042 Peptidase family M3B Oligopeptidase F (PepF; Pz-peptidase B; EC 3.4.24.-) is mostly bacterial and includes oligoendopeptidase F from Lactococcus lactis. This enzyme hydrolyzes peptides containing between 7 and 17 amino acids with fairly broad...; Region: M3B_Oligoendopeptidase_F; cd06459 572263001043 active site 572263001044 zinc binding site; other site 572263001045 Domain of unknown function DUF31; Region: DUF31; pfam01732 572263001046 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 572263001047 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 572263001048 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 572263001049 active site 572263001050 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 572263001051 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 572263001052 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 572263001053 active site 572263001054 motif I; other site 572263001055 motif II; other site 572263001056 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 572263001057 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 572263001058 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 572263001059 dimer interface; other site 572263001060 ssDNA binding site; other site 572263001061 tetramer (dimer of dimers) interface; other site 572263001062 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 572263001063 GTP-dependent nucleic acid-binding protein EngD; Reviewed; Region: PRK09601 572263001064 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 572263001065 G1 box; other site 572263001066 GTP/Mg2+ binding site; other site 572263001067 Switch I region; other site 572263001068 G2 box; other site 572263001069 Switch II region; other site 572263001070 G3 box; other site 572263001071 G4 box; other site 572263001072 G5 box; other site 572263001073 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 572263001074 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 572263001075 dimer interface; other site 572263001076 catalytic triad; other site 572263001077 peroxidatic and resolving cysteines; other site 572263001078 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 572263001079 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 572263001080 active site 572263001081 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 572263001082 dimerization interface; other site 572263001083 DPS ferroxidase diiron center; other site 572263001084 ion pore; other site 572263001085 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 572263001086 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 572263001087 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 572263001088 Predicted permease; Region: FtsX; cl11418 572263001089 Predicted permease; Region: FtsX; cl11418 572263001090 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 572263001091 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 572263001092 Walker A/P-loop; other site 572263001093 ATP binding site; other site 572263001094 Q-loop/lid; other site 572263001095 ABC transporter signature motif; other site 572263001096 Walker B; other site 572263001097 D-loop; other site 572263001098 H-loop/switch region; other site 572263001099 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13632 572263001100 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 572263001101 Walker A/P-loop; other site 572263001102 ATP binding site; other site 572263001103 Q-loop/lid; other site 572263001104 ABC transporter signature motif; other site 572263001105 Walker B; other site 572263001106 D-loop; other site 572263001107 H-loop/switch region; other site 572263001108 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13651 572263001109 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 572263001110 Walker A/P-loop; other site 572263001111 ATP binding site; other site 572263001112 Q-loop/lid; other site 572263001113 ABC transporter signature motif; other site 572263001114 Walker B; other site 572263001115 D-loop; other site 572263001116 H-loop/switch region; other site 572263001117 Cobalt transport protein; Region: CbiQ; cl00463 572263001118 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 572263001119 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 572263001120 nucleotide binding pocket; other site 572263001121 K-X-D-G motif; other site 572263001122 catalytic site; other site 572263001123 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 572263001124 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 572263001125 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cl00038 572263001126 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 572263001127 Chromate transporter; Region: Chromate_transp; cl00902 572263001128 Chromate transporter; Region: Chromate_transp; cl00902 572263001129 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 572263001130 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 572263001131 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 572263001132 Phage portal protein; Region: Phage_portal; cl01923 572263001133 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 572263001134 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 572263001135 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 572263001136 Walker A motif; other site 572263001137 ATP binding site; other site 572263001138 Walker B motif; other site 572263001139 arginine finger; other site 572263001140 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 572263001141 Phage Terminase; Region: Terminase_1; pfam03354 572263001142 Phage terminase, small subunit; Region: Terminase_4; cl01525 572263001143 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 572263001144 cofactor binding site; other site 572263001145 DNA binding site 572263001146 substrate interaction site; other site 572263001147 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 572263001148 polymerase nucleotide-binding site; other site 572263001149 DNA-binding residues; DNA binding site 572263001150 nucleotide binding site; other site 572263001151 primase nucleotide-binding site; other site 572263001152 C-terminal domain; Region: primase_Cterm; TIGR01613 572263001153 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 572263001154 hypothetical protein; Provisional; Region: PRK07143 572263001155 hypothetical protein; Provisional; Region: PRK07143 572263001156 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 572263001157 active site 572263001158 nucleotide binding site; other site 572263001159 HIGH motif; other site 572263001160 KMSKS motif; other site 572263001161 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 572263001162 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 572263001163 active site 572263001164 motif I; other site 572263001165 motif II; other site 572263001166 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 572263001167 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02193 572263001168 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573 572263001169 RNA binding site; other site 572263001170 active site 572263001171 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 572263001172 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 572263001173 putative tRNA-binding site; other site 572263001174 B3/4 domain; Region: B3_4; cl11458 572263001175 tRNA synthetase B5 domain; Region: B5; cl08394 572263001176 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 572263001177 motif 1; other site 572263001178 dimer interface; other site 572263001179 active site 572263001180 motif 3; other site 572263001181 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 572263001182 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 572263001183 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 572263001184 dimer interface; other site 572263001185 motif 1; other site 572263001186 active site 572263001187 motif 2; other site 572263001188 motif 3; other site 572263001189 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 572263001190 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 572263001191 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572263001192 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572263001193 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 572263001194 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 572263001195 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 572263001196 putative active site; other site 572263001197 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 572263001198 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 572263001199 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 572263001200 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 572263001201 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 572263001202 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 572263001203 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572263001204 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572263001205 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 572263001206 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 572263001207 mannose-6-phosphate isomerase; Provisional; Region: PLN03067; cl11740 572263001208 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 572263001209 active site 572263001210 phosphorylation site 572263001211 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569 572263001212 P-loop; other site 572263001213 active site 572263001214 phosphorylation site 572263001215 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 572263001216 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 572263001217 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 572263001218 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 572263001219 HIGH motif; other site 572263001220 active site 572263001221 nucleotide binding site; other site 572263001222 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 572263001223 KMSKS motif; other site 572263001224 active site 572263001225 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 572263001226 tRNA binding surface; other site 572263001227 anticodon binding site; other site 572263001228 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 572263001229 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 572263001230 CAP-like domain; other site 572263001231 active site 572263001232 primary dimer interface; other site 572263001233 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 572263001234 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 572263001235 ATP binding site; other site 572263001236 Mg2+ binding site; other site 572263001237 G-X-G motif; other site 572263001238 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 572263001239 anchoring element; other site 572263001240 dimer interface; other site 572263001241 ATP binding site; other site 572263001242 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 572263001243 active site 572263001244 putative metal-binding site; other site 572263001245 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 572263001246 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 572263001247 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl12058 572263001248 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 572263001249 5'-3' exonuclease; Region: 53EXOc; smart00475 572263001250 5'-3' exonuclease; T5 type 5'-3' exonuclease domains may co-occur with DNA polymerase I (Pol I) domains, or be part of Pol I containing complexes. They digest dsDNA and ssDNA, releasing mono-,di- and tri-nucleotides, as well as oligonucleotides, and...; Region: 53EXOc; cd00008 572263001251 metal binding site I; metal-binding site 572263001252 putative ssDNA interaction site; other site 572263001253 metal binding site II; metal-binding site 572263001254 DNA polymerase III DnaE; Validated; Region: dnaE; PRK07135 572263001255 DNA polymerase alpha chain like domain; Region: POLIIIAc; cl02625 572263001256 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 572263001257 Ribosome-binding factor A; Region: RBFA; cl00542 572263001258 translation initiation factor IF-2; Provisional; Region: infB; PRK12312 572263001259 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 572263001260 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases...; Region: IF2_eIF5B; cd01887 572263001261 G1 box; other site 572263001262 putative GEF interaction site; other site 572263001263 GTP/Mg2+ binding site; other site 572263001264 Switch I region; other site 572263001265 G2 box; other site 572263001266 G3 box; other site 572263001267 Switch II region; other site 572263001268 G4 box; other site 572263001269 G5 box; other site 572263001270 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702 572263001271 Translation-initiation factor 2; Region: IF-2; pfam11987 572263001272 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692 572263001273 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 572263001274 putative RNA binding cleft; other site 572263001275 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 572263001276 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 572263001277 G-X-X-G motif; other site 572263001278 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 572263001279 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 572263001280 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 572263001281 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 572263001282 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 572263001283 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 572263001284 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 572263001285 elongation factor Tu; Reviewed; Region: PRK00049 572263001286 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 572263001287 G1 box; other site 572263001288 GEF interaction site; other site 572263001289 GTP/Mg2+ binding site; other site 572263001290 Switch I region; other site 572263001291 G2 box; other site 572263001292 G3 box; other site 572263001293 Switch II region; other site 572263001294 G4 box; other site 572263001295 G5 box; other site 572263001296 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 572263001297 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 572263001298 Antibiotic Binding Site; other site 572263001299 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 572263001300 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 572263001301 Walker A motif; other site 572263001302 ATP binding site; other site 572263001303 Walker B motif; other site 572263001304 arginine finger; other site 572263001305 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 572263001306 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 572263001307 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family. DERA belongs to the class I aldolases and catalyzes a reversible aldol reaction between acetaldehyde and glyceraldehyde 3-phosphate to generate 2-deoxyribose 5-phosphate. DERA is unique in...; Region: DeoC; cd00959 572263001308 intersubunit interface; other site 572263001309 active site 572263001310 catalytic residue; other site 572263001311 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 572263001312 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 572263001313 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 572263001314 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 572263001315 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 572263001316 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 572263001317 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 572263001318 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 572263001319 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 572263001320 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12903 572263001321 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 572263001322 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 572263001323 nucleotide binding region; other site 572263001324 ATP-binding site; other site 572263001325 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 572263001326 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12903 572263001327 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 572263001328 active site 572263001329 catalytic triad; other site 572263001330 oxyanion hole; other site 572263001331 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 572263001332 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 572263001333 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 572263001334 6-phosphofructokinase; Provisional; Region: PRK03202 572263001335 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cl00204 572263001336 active site 572263001337 ADP/pyrophosphate binding site; other site 572263001338 dimerization interface; other site 572263001339 allosteric effector site; other site 572263001340 fructose-1,6-bisphosphate binding site; other site 572263001341 Dimeric dUTPase [Carbohydrate transport and metabolism]; Region: COG4508 572263001342 dUTPase; Region: dUTPase_2; pfam08761 572263001343 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 572263001344 YlqF. Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases...; Region: YlqF; cd01856 572263001345 GTP/Mg2+ binding site; other site 572263001346 G4 box; other site 572263001347 G5 box; other site 572263001348 G1 box; other site 572263001349 Switch I region; other site 572263001350 G2 box; other site 572263001351 G3 box; other site 572263001352 Switch II region; other site 572263001353 SmpB protein; Region: SmpB; cl00482 572263001354 Staphylococcal nuclease homologues; Region: SNc; smart00318 572263001355 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 572263001356 Catalytic site; other site 572263001357 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 572263001358 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 572263001359 Walker A/P-loop; other site 572263001360 ATP binding site; other site 572263001361 Tat binding protein 1(TBP-1)-interacting protein (TBPIP); Region: TBPIP; pfam07106 572263001362 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 572263001363 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 572263001364 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 572263001365 ATP binding site; other site 572263001366 Q-loop/lid; other site 572263001367 ABC transporter signature motif; other site 572263001368 Walker B; other site 572263001369 D-loop; other site 572263001370 H-loop/switch region; other site 572263001371 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 572263001372 active site 572263001373 catalytic residues; other site 572263001374 CTP synthetase; Validated; Region: pyrG; PRK05380 572263001375 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113 572263001376 Catalytic site; other site 572263001377 active site 572263001378 UTP binding site; other site 572263001379 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 572263001380 active site 572263001381 putative oxyanion hole; other site 572263001382 catalytic triad; other site 572263001383 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 572263001384 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 572263001385 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 572263001386 dimer interface; other site 572263001387 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 572263001388 anticodon binding site; other site 572263001389 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 572263001390 motif 1; other site 572263001391 dimer interface; other site 572263001392 active site 572263001393 motif 2; other site 572263001394 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 572263001395 active site 572263001396 motif 3; other site 572263001397 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 572263001398 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 572263001399 dimer interface; other site 572263001400 motif 1; other site 572263001401 active site 572263001402 motif 2; other site 572263001403 motif 3; other site 572263001404 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 572263001405 Protein export membrane protein; Region: SecD_SecF; cl14618 572263001406 protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966 572263001407 Protein export membrane protein; Region: SecD_SecF; cl14618 572263001408 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378 572263001409 dimer interface; other site 572263001410 glycine-pyridoxal phosphate binding site; other site 572263001411 active site 572263001412 folate binding site; other site 572263001413 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 572263001414 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 572263001415 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 572263001416 dimer interface; other site 572263001417 conserved gate region; other site 572263001418 putative PBP binding loops; other site 572263001419 ABC-ATPase subunit interface; other site 572263001420 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 572263001421 Walker A/P-loop; other site 572263001422 ATP binding site; other site 572263001423 Q-loop/lid; other site 572263001424 ABC transporter signature motif; other site 572263001425 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 572263001426 ABC transporter signature motif; other site 572263001427 Walker B; other site 572263001428 D-loop; other site 572263001429 H-loop/switch region; other site 572263001430 TOBE domain; Region: TOBE_2; cl01440 572263001431 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 572263001432 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 572263001433 putative active site; other site 572263001434 putative metal binding site; other site 572263001435 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 572263001436 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life...; Region: HINT_subgroup; cd01277 572263001437 HIT family signature motif; other site 572263001438 catalytic residue; other site 572263001439 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 572263001440 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 572263001441 active site 572263001442 motif I; other site 572263001443 motif II; other site 572263001444 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside...; Region: NK; cl11962 572263001445 active site 572263001446 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 572263001447 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 572263001448 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 572263001449 Walker A/P-loop; other site 572263001450 ATP binding site; other site 572263001451 Q-loop/lid; other site 572263001452 ABC transporter signature motif; other site 572263001453 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 572263001454 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 572263001455 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 572263001456 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 572263001457 TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase...; Region: trmE; cd04164 572263001458 G1 box; other site 572263001459 GTP/Mg2+ binding site; other site 572263001460 Switch I region; other site 572263001461 G2 box; other site 572263001462 Switch II region; other site 572263001463 G3 box; other site 572263001464 G4 box; other site 572263001465 G5 box; other site 572263001466 Protein of unknown function DUF262; Region: DUF262; pfam03235 572263001467 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 572263001468 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 572263001469 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 572263001470 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 572263001471 cofactor binding site; other site 572263001472 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 572263001473 DNA binding site 572263001474 substrate interaction site; other site 572263001475 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553 572263001476 NAD synthase; Region: NAD_synthase; pfam02540 572263001477 homodimer interface; other site 572263001478 NAD binding pocket; other site 572263001479 ATP binding pocket; other site 572263001480 Mg binding site; other site 572263001481 active-site loop 572263001482 Domain of unknown function DUF28; Region: DUF28; cl00361 572263001483 hypothetical protein; Provisional; Region: PRK06148 572263001484 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 572263001485 active site 572263001486 tetramer interface; other site 572263001487 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 572263001488 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 572263001489 NAD binding site; other site 572263001490 dimer interface; other site 572263001491 tetramer (dimer of dimers) interface; other site 572263001492 substrate binding site; other site 572263001493 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 572263001494 Mycoplasma MFS transporter; Region: MFS_Mycoplasma; pfam07672 572263001495 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 572263001496 DNA photolyase; Region: DNA_photolyase; pfam00875 572263001497 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 572263001498 Protein of unknown function (DUF795); Region: DUF795; cl14188 572263001499 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; cl02331 572263001500 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 572263001501 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 572263001502 HSP70 interaction site; other site 572263001503 DnaJ C terminal region; Region: DnaJ_C; pfam01556 572263001504 DnaJ C terminal region; Region: DnaJ_C; pfam01556 572263001505 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 572263001506 GIY-YIG catalytic domain; Region: GIY-YIG; cl01061 572263001507 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 572263001508 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 572263001509 Recombination protein O N terminal; Region: RecO_N; pfam11967 572263001510 DNA repair protein RecO; Region: reco; TIGR00613 572263001511 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 572263001512 S-adenosylmethionine binding site; other site 572263001513 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071 572263001514 catalytic site; other site 572263001515 G-X2-G-X-G-K; other site 572263001516 ribosome-associated GTPase; Reviewed; Region: PRK00098 572263001517 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854 572263001518 GTPase/OB domain interface; other site 572263001519 GTPase/Zn-binding domain interface; other site 572263001520 GTP/Mg2+ binding site; other site 572263001521 G4 box; other site 572263001522 G5 box; other site 572263001523 G1 box; other site 572263001524 Switch I region; other site 572263001525 G2 box; other site 572263001526 G3 box; other site 572263001527 Switch II region; other site 572263001528 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 572263001529 substrate binding site; other site 572263001530 hexamer interface; other site 572263001531 metal-binding site 572263001532 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 572263001533 Transposase [DNA replication, recombination, and repair]; Region: COG5421 572263001534 Transposase DDE domain; Region: Transposase_11; pfam01609 572263001535 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 572263001536 DNA binding site 572263001537 substrate interaction site; other site 572263001538 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 572263001539 active site 572263001540 phosphorylation site 572263001541 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 572263001542 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 572263001543 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 572263001544 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 572263001545 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 572263001546 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_mannitol; cd05567 572263001547 active site 572263001548 P-loop; other site 572263001549 phosphorylation site 572263001550 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 572263001551 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 572263001552 putative active site; other site 572263001553 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 572263001554 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 572263001555 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 572263001556 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 572263001557 alpha subunit interaction interface; other site 572263001558 Walker A motif; other site 572263001559 ATP binding site; other site 572263001560 Walker B motif; other site 572263001561 inhibitor binding site; inhibition site 572263001562 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 572263001563 ATP synthase; Region: ATP-synt; cl00365 572263001564 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 572263001565 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 572263001566 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 572263001567 beta subunit interaction interface; other site 572263001568 Walker A motif; other site 572263001569 ATP binding site; other site 572263001570 Walker B motif; other site 572263001571 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 572263001572 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl00491 572263001573 ATP synthase subunit C; Region: ATP-synt_C; cl00466 572263001574 ATP synthase A chain; Region: ATP-synt_A; cl00413 572263001575 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 572263001576 DNA Polymerase IV/Kappa; Region: Pol_IV_kappa; cd03586 572263001577 active site 572263001578 DNA binding site 572263001579 Phosphopantetheine attachment site; Region: PP-binding; cl09936 572263001580 GTPase ObgE; Reviewed; Region: obgE; PRK12297 572263001581 GTP1/OBG; Region: GTP1_OBG; pfam01018 572263001582 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 572263001583 G1 box; other site 572263001584 GTP/Mg2+ binding site; other site 572263001585 Switch I region; other site 572263001586 G2 box; other site 572263001587 G3 box; other site 572263001588 Switch II region; other site 572263001589 G4 box; other site 572263001590 G5 box; other site 572263001591 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 572263001592 Phosphotransferase enzyme family; Region: APH; pfam01636 572263001593 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 572263001594 active site 572263001595 ATP binding site; other site 572263001596 substrate binding site; other site 572263001597 dimer interface; other site 572263001598 RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468 572263001599 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 572263001600 hexamer interface; other site 572263001601 Walker A motif; other site 572263001602 ATP binding site; other site 572263001603 Walker B motif; other site 572263001604 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 572263001605 Phospholipase D. Active site motifs; The PLD superfamily includes enzymes involved in signal transduction, lipid biosynthesis, endonucleases and open reading frames in pathogenic viruses and bacteria. PLD hydrolyzes the terminal phosphodiester bond of...; Region: PLDc; cd00138 572263001606 active site 572263001607 signature motif; other site 572263001608 Phospholipase D. Active site motifs; The PLD superfamily includes enzymes involved in signal transduction, lipid biosynthesis, endonucleases and open reading frames in pathogenic viruses and bacteria. PLD hydrolyzes the terminal phosphodiester bond of...; Region: PLDc; cd00138 572263001609 active site 572263001610 signature motif; other site 572263001611 ribonuclease R; Region: RNase_R; TIGR02063 572263001612 RNB domain; Region: RNB; pfam00773 572263001613 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 572263001614 RNA binding site; other site 572263001615 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 572263001616 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 572263001617 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 572263001618 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 572263001619 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 572263001620 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 572263001621 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 572263001622 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 572263001623 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 572263001624 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 572263001625 active site 572263001626 dimer interface; other site 572263001627 motif 1; other site 572263001628 motif 2; other site 572263001629 motif 3; other site 572263001630 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 572263001631 anticodon binding site; other site 572263001632 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 572263001633 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 572263001634 active site 572263001635 HIGH motif; other site 572263001636 dimer interface; other site 572263001637 KMSKS motif; other site 572263001638 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cl00164 572263001639 active site turn 572263001640 phosphorylation site 572263001641 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 572263001642 bacterial Ribonuclease HIII-like; Region: RNaseH_typeII_bacteria_HIII_like; cd06590 572263001643 active site 572263001644 Uncharacterized protein family (UPF0154); Region: UPF0154; cl01536 572263001645 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 572263001646 Sulfatase; Region: Sulfatase; cl10460 572263001647 ZIP Zinc transporter; Region: Zip; pfam02535 572263001648 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254 572263001649 putative nucleotide binding site; other site 572263001650 uridine monophosphate binding site; other site 572263001651 homohexameric interface; other site 572263001652 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cl00240 572263001653 hinge region; other site 572263001654 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 572263001655 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 572263001656 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 572263001657 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK02173 572263001658 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 572263001659 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 572263001660 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 572263001661 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 572263001662 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 572263001663 Rpb1 (beta') - Rpb6 (omega) interaction site; other site 572263001664 Rpb1 (beta') - Rpb2 (beta) interaction site; other site 572263001665 G-loop; other site 572263001666 DNA binding site 572263001667 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 572263001668 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 572263001669 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591 572263001670 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 572263001671 RPB1 interaction site; other site 572263001672 RPB10 interaction site; other site 572263001673 RPB11 interaction site; other site 572263001674 RPB3 interaction site; other site 572263001675 RPB12 interaction site; other site 572263001676 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 572263001677 core dimer interface; other site 572263001678 peripheral dimer interface; other site 572263001679 L10 interface; other site 572263001680 L11 interface; other site 572263001681 putative EF-Tu interaction site; other site 572263001682 putative EF-G interaction site; other site 572263001683 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797 572263001684 23S rRNA interface; other site 572263001685 Interface with L7/L12 ribosomal proteins; other site 572263001686 Domain of unknown function (DUF205); Region: DUF205; cl00410 572263001687 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 572263001688 Ribosomal protein L20; Region: Ribosomal_L20; cl00393 572263001689 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 572263001690 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 572263001691 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 572263001692 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 572263001693 Thymidine kinase; Region: TK; cl00631 572263001694 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette...; Region: TM_PBP1_transp_TpRbsC_like; cd06580 572263001695 TM-ABC transporter signature motif; other site 572263001696 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette...; Region: TM_PBP1_transp_TpRbsC_like; cd06580 572263001697 TM-ABC transporter signature motif; other site 572263001698 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 572263001699 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 572263001700 Walker A/P-loop; other site 572263001701 ATP binding site; other site 572263001702 Q-loop/lid; other site 572263001703 ABC transporter signature motif; other site 572263001704 Walker B; other site 572263001705 D-loop; other site 572263001706 H-loop/switch region; other site 572263001707 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_II; cd03215 572263001708 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 572263001709 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 572263001710 dimer interface; other site 572263001711 substrate binding site; other site 572263001712 metal binding sites; metal-binding site 572263001713 BAX inhibitor (BI)-1 like protein family. Mammalian members of this family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well characterized oncogene, or...; Region: BI-1-like; cl00473 572263001714 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 572263001715 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 572263001716 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 572263001717 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 572263001718 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 572263001719 Cation transport protein; Region: TrkH; cl10514 572263001720 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 572263001721 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 572263001722 active site 572263001723 dimer interface; other site 572263001724 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 572263001725 dimer interface; other site 572263001726 active site 572263001727 DNA polymerase III PolC; Validated; Region: polC; PRK00448 572263001728 DNA polymerase alpha chain like domain; Region: POLIIIAc; cl02625 572263001729 DEDDh exonucleases, part of the DnaQ-like (or DEDD) exonuclease superfamily, catalyze the excision of nucleoside monophosphates at the DNA or RNA termini in the 3'-5' direction. These proteins contain four invariant acidic residues in three conserved...; Region: DEDDh; cd06127 572263001730 active site 572263001731 substrate binding site; other site 572263001732 catalytic site; other site 572263001733 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 572263001734 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 572263001735 Catalytic site; other site 572263001736 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 572263001737 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 572263001738 Walker A/P-loop; other site 572263001739 ATP binding site; other site 572263001740 Q-loop/lid; other site 572263001741 ABC transporter signature motif; other site 572263001742 Walker B; other site 572263001743 D-loop; other site 572263001744 H-loop/switch region; other site 572263001745 Predicted permease; Region: FtsX; cl11418 572263001746 domain; Region: GreA_GreB_N; pfam03449 572263001747 C-term; Region: GreA_GreB; pfam01272 572263001748 MatE; Region: MatE; pfam01554 572263001749 hypothetical protein; Provisional; Region: PRK09609 572263001750 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 572263001751 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 572263001752 HIGH motif; other site 572263001753 active site 572263001754 nucleotide binding site; other site 572263001755 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 572263001756 active site 572263001757 KMSKS motif; other site 572263001758 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 572263001759 tRNA binding surface; other site 572263001760 anticodon binding site; other site 572263001761 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 572263001762 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 572263001763 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 572263001764 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 572263001765 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 572263001766 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 572263001767 60Kd inner membrane protein; Region: 60KD_IMP; cl00489