-- dump date 20140619_155948 -- class Genbank::misc_feature -- table misc_feature_note -- id note 512564000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 512564000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512564000003 Walker A motif; other site 512564000004 ATP binding site [chemical binding]; other site 512564000005 Walker B motif; other site 512564000006 arginine finger; other site 512564000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 512564000008 DnaA box-binding interface [nucleotide binding]; other site 512564000009 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 512564000010 putative DNA binding surface [nucleotide binding]; other site 512564000011 DNA polymerase III beta subunit; Region: POL3Bc; smart00480 512564000012 dimer interface [polypeptide binding]; other site 512564000013 beta-clamp/clamp loader binding surface; other site 512564000014 beta-clamp/translesion DNA polymerase binding surface; other site 512564000015 S4 domain; Region: S4_2; cl17325 512564000016 asparagine synthetase AsnA; Provisional; Region: PRK05425 512564000017 motif 1; other site 512564000018 dimer interface [polypeptide binding]; other site 512564000019 active site 512564000020 motif 2; other site 512564000021 motif 3; other site 512564000022 Uncharacterized conserved protein [Function unknown]; Region: COG4095 512564000023 PQ loop repeat; Region: PQ-loop; cl17546 512564000024 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 512564000025 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 512564000026 trmE is a tRNA modification GTPase; Region: trmE; cd04164 512564000027 G1 box; other site 512564000028 GTP/Mg2+ binding site [chemical binding]; other site 512564000029 Switch I region; other site 512564000030 G2 box; other site 512564000031 Switch II region; other site 512564000032 G3 box; other site 512564000033 G5 box; other site 512564000034 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 512564000035 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 512564000036 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 512564000037 active site 512564000038 Zn binding site [ion binding]; other site 512564000039 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 512564000040 active site 512564000041 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 512564000042 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512564000043 S-adenosylmethionine binding site [chemical binding]; other site 512564000044 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 512564000045 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 512564000046 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 512564000047 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 512564000048 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 512564000049 active site 512564000050 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 512564000051 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512564000052 S-adenosylmethionine binding site [chemical binding]; other site 512564000053 hypothetical protein; Provisional; Region: PRK14644 512564000054 Sm and related proteins; Region: Sm_like; cl00259 512564000055 heptamer interface [polypeptide binding]; other site 512564000056 Sm1 motif; other site 512564000057 hexamer interface [polypeptide binding]; other site 512564000058 RNA binding site [nucleotide binding]; other site 512564000059 Sm2 motif; other site 512564000060 transcription termination factor NusA; Region: NusA; TIGR01953 512564000061 NusA-like KH domain; Region: KH_5; pfam13184 512564000062 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 512564000063 G-X-X-G motif; other site 512564000064 Protein of unknown function (DUF448); Region: DUF448; pfam04296 512564000065 putative RNA binding cleft [nucleotide binding]; other site 512564000066 translation initiation factor IF-2; Region: IF-2; TIGR00487 512564000067 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 512564000068 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 512564000069 G1 box; other site 512564000070 putative GEF interaction site [polypeptide binding]; other site 512564000071 GTP/Mg2+ binding site [chemical binding]; other site 512564000072 Switch I region; other site 512564000073 G2 box; other site 512564000074 G3 box; other site 512564000075 Switch II region; other site 512564000076 G4 box; other site 512564000077 G5 box; other site 512564000078 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 512564000079 Translation-initiation factor 2; Region: IF-2; pfam11987 512564000080 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 512564000081 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 512564000082 active site 512564000083 enolase; Provisional; Region: eno; PRK00077 512564000084 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 512564000085 dimer interface [polypeptide binding]; other site 512564000086 metal binding site [ion binding]; metal-binding site 512564000087 substrate binding pocket [chemical binding]; other site 512564000088 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 512564000089 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 512564000090 dimer interface [polypeptide binding]; other site 512564000091 active site 512564000092 metal binding site [ion binding]; metal-binding site 512564000093 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 512564000094 gating phenylalanine in ion channel; other site 512564000095 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 512564000096 catalytic motif [active] 512564000097 Zn binding site [ion binding]; other site 512564000098 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 512564000099 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 512564000100 conserved cys residue [active] 512564000101 DNA polymerase III PolC; Validated; Region: polC; PRK00448 512564000102 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 512564000103 generic binding surface II; other site 512564000104 generic binding surface I; other site 512564000105 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 512564000106 active site 512564000107 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 512564000108 active site 512564000109 catalytic site [active] 512564000110 substrate binding site [chemical binding]; other site 512564000111 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 512564000112 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 512564000113 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 512564000114 Type III pantothenate kinase; Region: Pan_kinase; cl17198 512564000115 Protein of unknown function DUF45; Region: DUF45; cl00636 512564000116 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 512564000117 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 512564000118 HSP70 interaction site [polypeptide binding]; other site 512564000119 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 512564000120 Zn binding sites [ion binding]; other site 512564000121 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 512564000122 dimer interface [polypeptide binding]; other site 512564000123 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 512564000124 phosphoglyceromutase; Provisional; Region: PRK05434 512564000125 LemA family; Region: LemA; cl00742 512564000126 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 512564000127 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 512564000128 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 512564000129 UGMP family protein; Validated; Region: PRK09604 512564000130 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 512564000131 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547 512564000132 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512564000133 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 512564000134 active site 512564000135 motif I; other site 512564000136 motif II; other site 512564000137 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 512564000138 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 512564000139 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512564000140 active site 512564000141 motif I; other site 512564000142 motif II; other site 512564000143 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 512564000144 elongation factor Tu; Reviewed; Region: PRK00049 512564000145 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 512564000146 G1 box; other site 512564000147 GEF interaction site [polypeptide binding]; other site 512564000148 GTP/Mg2+ binding site [chemical binding]; other site 512564000149 Switch I region; other site 512564000150 G2 box; other site 512564000151 G3 box; other site 512564000152 Switch II region; other site 512564000153 G4 box; other site 512564000154 G5 box; other site 512564000155 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 512564000156 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 512564000157 Antibiotic Binding Site [chemical binding]; other site 512564000158 CTP synthetase; Validated; Region: pyrG; PRK05380 512564000159 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 512564000160 Catalytic site [active] 512564000161 active site 512564000162 UTP binding site [chemical binding]; other site 512564000163 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 512564000164 active site 512564000165 putative oxyanion hole; other site 512564000166 catalytic triad [active] 512564000167 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 512564000168 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 512564000169 active site 512564000170 HIGH motif; other site 512564000171 dimer interface [polypeptide binding]; other site 512564000172 KMSKS motif; other site 512564000173 The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cl00320 512564000174 putative tRNA-binding site [nucleotide binding]; other site 512564000175 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 512564000176 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 512564000177 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit [DNA replication, recombination, and repair]; Region: GyrB; COG0187 512564000178 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512564000179 Mg2+ binding site [ion binding]; other site 512564000180 G-X-G motif; other site 512564000181 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 512564000182 anchoring element; other site 512564000183 dimer interface [polypeptide binding]; other site 512564000184 ATP binding site [chemical binding]; other site 512564000185 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 512564000186 active site 512564000187 putative metal-binding site [ion binding]; other site 512564000188 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 512564000189 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 512564000190 AAA domain; Region: AAA_23; pfam13476 512564000191 Walker A/P-loop; other site 512564000192 ATP binding site [chemical binding]; other site 512564000193 Q-loop/lid; other site 512564000194 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 512564000195 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 512564000196 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 512564000197 ABC transporter signature motif; other site 512564000198 Walker B; other site 512564000199 D-loop; other site 512564000200 H-loop/switch region; other site 512564000201 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 512564000202 dimerization interface [polypeptide binding]; other site 512564000203 active site 512564000204 metal binding site [ion binding]; metal-binding site 512564000205 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cl00054 512564000206 dsRNA binding site [nucleotide binding]; other site 512564000207 putative phosphate acyltransferase; Provisional; Region: PRK05331 512564000208 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 512564000209 DAK2 domain; Region: Dak2; pfam02734 512564000210 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 512564000211 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 512564000212 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512564000213 S-adenosylmethionine binding site [chemical binding]; other site 512564000214 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 512564000215 active site 512564000216 catalytic residues [active] 512564000217 metal binding site [ion binding]; metal-binding site 512564000218 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 512564000219 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 512564000220 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 512564000221 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 512564000222 Walker A/P-loop; other site 512564000223 ATP binding site [chemical binding]; other site 512564000224 Q-loop/lid; other site 512564000225 ABC transporter signature motif; other site 512564000226 Walker B; other site 512564000227 D-loop; other site 512564000228 H-loop/switch region; other site 512564000229 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 512564000230 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 512564000231 GTP/Mg2+ binding site [chemical binding]; other site 512564000232 G4 box; other site 512564000233 G5 box; other site 512564000234 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 512564000235 G1 box; other site 512564000236 Switch I region; other site 512564000237 G2 box; other site 512564000238 G3 box; other site 512564000239 Switch II region; other site 512564000240 DivIVA protein; Region: DivIVA; pfam05103 512564000241 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 512564000242 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 512564000243 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 512564000244 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 512564000245 active site 512564000246 metal binding site [ion binding]; metal-binding site 512564000247 homotetramer interface [polypeptide binding]; other site 512564000248 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 512564000249 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512564000250 active site 512564000251 motif I; other site 512564000252 motif II; other site 512564000253 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 512564000254 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 512564000255 RNA/DNA hybrid binding site [nucleotide binding]; other site 512564000256 active site 512564000257 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 512564000258 Phosphotransferase enzyme family; Region: APH; pfam01636 512564000259 active site 512564000260 substrate binding site [chemical binding]; other site 512564000261 ATP binding site [chemical binding]; other site 512564000262 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 512564000263 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 512564000264 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 512564000265 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 512564000266 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 512564000267 DHH family; Region: DHH; pfam01368 512564000268 DHHA1 domain; Region: DHHA1; pfam02272 512564000269 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 512564000270 DHH family; Region: DHH; pfam01368 512564000271 DHHA1 domain; Region: DHHA1; pfam02272 512564000272 Peptidase family M23; Region: Peptidase_M23; pfam01551 512564000273 Protein of unknown function (DUF402); Region: DUF402; cl00979 512564000274 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 512564000275 SmpB-tmRNA interface; other site 512564000276 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512564000277 S-adenosylmethionine binding site [chemical binding]; other site 512564000278 DNA gyrase subunit A; Validated; Region: PRK05560 512564000279 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 512564000280 CAP-like domain; other site 512564000281 active site 512564000282 primary dimer interface [polypeptide binding]; other site 512564000283 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 512564000284 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 512564000285 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 512564000286 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 512564000287 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 512564000288 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 512564000289 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 512564000290 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 512564000291 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 512564000292 active site 512564000293 dihydroneopterin triphosphate pyrophosphatase; Provisional; Region: nudB; PRK09438 512564000294 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 512564000295 endonuclease IV; Provisional; Region: PRK01060 512564000296 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 512564000297 AP (apurinic/apyrimidinic) site pocket; other site 512564000298 DNA interaction; other site 512564000299 Metal-binding active site; metal-binding site 512564000300 Transcriptional regulators [Transcription]; Region: PurR; COG1609 512564000301 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 512564000302 DNA binding site [nucleotide binding] 512564000303 domain linker motif; other site 512564000304 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 512564000305 ligand binding site [chemical binding]; other site 512564000306 dimerization interface [polypeptide binding]; other site 512564000307 GTP-binding protein YchF; Reviewed; Region: PRK09601 512564000308 YchF GTPase; Region: YchF; cd01900 512564000309 G1 box; other site 512564000310 GTP/Mg2+ binding site [chemical binding]; other site 512564000311 Switch I region; other site 512564000312 G2 box; other site 512564000313 Switch II region; other site 512564000314 G3 box; other site 512564000315 G4 box; other site 512564000316 G5 box; other site 512564000317 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 512564000318 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 512564000319 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 512564000320 alpha subunit interaction interface [polypeptide binding]; other site 512564000321 Walker A motif; other site 512564000322 ATP binding site [chemical binding]; other site 512564000323 Walker B motif; other site 512564000324 inhibitor binding site; inhibition site 512564000325 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 512564000326 F0F1 ATP synthase subunit alpha; Validated; Region: PRK07165 512564000327 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 512564000328 Walker A motif; other site 512564000329 ATP binding site [chemical binding]; other site 512564000330 Walker B motif; other site 512564000331 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cl00365 512564000332 epsilon subunit interface [polypeptide binding]; other site 512564000333 Protein of unknown function (DUF2714); Region: DUF2714; pfam10896 512564000334 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 512564000335 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 512564000336 putative homodimer interface [polypeptide binding]; other site 512564000337 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 512564000338 heterodimer interface [polypeptide binding]; other site 512564000339 homodimer interface [polypeptide binding]; other site 512564000340 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 512564000341 S-adenosylmethionine synthetase; Validated; Region: PRK05250 512564000342 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 512564000343 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 512564000344 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 512564000345 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 512564000346 interface (dimer of trimers) [polypeptide binding]; other site 512564000347 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 512564000348 Substrate-binding/catalytic site; other site 512564000349 Zn-binding sites [ion binding]; other site 512564000350 GTPase Era; Reviewed; Region: era; PRK00089 512564000351 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 512564000352 G1 box; other site 512564000353 GTP/Mg2+ binding site [chemical binding]; other site 512564000354 Switch I region; other site 512564000355 G2 box; other site 512564000356 Switch II region; other site 512564000357 G3 box; other site 512564000358 G4 box; other site 512564000359 G5 box; other site 512564000360 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 512564000361 active site 512564000362 catalytic motif [active] 512564000363 Zn binding site [ion binding]; other site 512564000364 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 512564000365 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 512564000366 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 512564000367 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 512564000368 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 512564000369 active site 512564000370 catalytic site [active] 512564000371 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 512564000372 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 512564000373 50S ribosomal protein L4; Provisional; Region: rplD; PRK14907 512564000374 50S ribosomal protein L23; Reviewed; Region: rplW; PRK12280 512564000375 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 512564000376 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 512564000377 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 512564000378 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 512564000379 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 512564000380 putative translocon binding site; other site 512564000381 protein-rRNA interface [nucleotide binding]; other site 512564000382 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 512564000383 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 512564000384 G-X-X-G motif; other site 512564000385 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 512564000386 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 512564000387 23S rRNA interface [nucleotide binding]; other site 512564000388 5S rRNA interface [nucleotide binding]; other site 512564000389 putative antibiotic binding site [chemical binding]; other site 512564000390 L25 interface [polypeptide binding]; other site 512564000391 L27 interface [polypeptide binding]; other site 512564000392 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 512564000393 23S rRNA interface [nucleotide binding]; other site 512564000394 putative translocon interaction site; other site 512564000395 signal recognition particle (SRP54) interaction site; other site 512564000396 L23 interface [polypeptide binding]; other site 512564000397 trigger factor interaction site; other site 512564000398 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 512564000399 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 512564000400 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 512564000401 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 512564000402 RNA binding site [nucleotide binding]; other site 512564000403 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 512564000404 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 512564000405 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 512564000406 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 512564000407 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 512564000408 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 512564000409 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 512564000410 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 512564000411 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 512564000412 5S rRNA interface [nucleotide binding]; other site 512564000413 L27 interface [polypeptide binding]; other site 512564000414 23S rRNA interface [nucleotide binding]; other site 512564000415 L5 interface [polypeptide binding]; other site 512564000416 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 512564000417 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 512564000418 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 512564000419 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 512564000420 Methyltransferase domain; Region: Methyltransf_26; pfam13659 512564000421 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 512564000422 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 512564000423 SecY translocase; Region: SecY; pfam00344 512564000424 adenylate kinase; Region: adk; TIGR01351 512564000425 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 512564000426 AMP-binding site [chemical binding]; other site 512564000427 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 512564000428 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 512564000429 active site 512564000430 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 512564000431 rRNA binding site [nucleotide binding]; other site 512564000432 predicted 30S ribosome binding site; other site 512564000433 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 512564000434 30S ribosomal protein S13; Region: bact_S13; TIGR03631 512564000435 30S ribosomal protein S11; Validated; Region: PRK05309 512564000436 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 512564000437 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 512564000438 alphaNTD - beta interaction site [polypeptide binding]; other site 512564000439 alphaNTD homodimer interface [polypeptide binding]; other site 512564000440 alphaNTD - beta' interaction site [polypeptide binding]; other site 512564000441 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 512564000442 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 512564000443 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 512564000444 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 512564000445 putative active site [active] 512564000446 putative metal binding site [ion binding]; other site 512564000447 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 512564000448 ribonuclease R; Region: RNase_R; TIGR02063 512564000449 RNB domain; Region: RNB; pfam00773 512564000450 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 512564000451 RNA binding site [nucleotide binding]; other site 512564000452 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 512564000453 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 512564000454 S-adenosylmethionine binding site [chemical binding]; other site 512564000455 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 512564000456 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 512564000457 active site 512564000458 HIGH motif; other site 512564000459 KMSKS motif; other site 512564000460 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 512564000461 tRNA binding surface [nucleotide binding]; other site 512564000462 anticodon binding site; other site 512564000463 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 512564000464 methionine sulfoxide reductase B; Provisional; Region: PRK00222 512564000465 SelR domain; Region: SelR; pfam01641 512564000466 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02193 512564000467 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 512564000468 RNA binding site [nucleotide binding]; other site 512564000469 active site 512564000470 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512564000471 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 512564000472 active site 512564000473 motif I; other site 512564000474 motif II; other site 512564000475 hypothetical protein; Provisional; Region: PRK07143 512564000476 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 512564000477 active site 512564000478 nucleotide binding site [chemical binding]; other site 512564000479 HIGH motif; other site 512564000480 KMSKS motif; other site 512564000481 Riboflavin kinase; Region: Flavokinase; cl03312 512564000482 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 512564000483 16S/18S rRNA binding site [nucleotide binding]; other site 512564000484 S13e-L30e interaction site [polypeptide binding]; other site 512564000485 25S rRNA binding site [nucleotide binding]; other site 512564000486 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 512564000487 RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468 512564000488 hexamer interface [polypeptide binding]; other site 512564000489 Walker A motif; other site 512564000490 ATP binding site [chemical binding]; other site 512564000491 Walker B motif; other site 512564000492 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 512564000493 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 512564000494 putative active site [active] 512564000495 metal binding site [ion binding]; metal-binding site 512564000496 homodimer binding site [polypeptide binding]; other site 512564000497 Amino acid permease; Region: AA_permease_2; pfam13520 512564000498 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 512564000499 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 512564000500 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 512564000501 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 512564000502 Walker A/P-loop; other site 512564000503 ATP binding site [chemical binding]; other site 512564000504 Q-loop/lid; other site 512564000505 ABC transporter signature motif; other site 512564000506 Walker B; other site 512564000507 D-loop; other site 512564000508 H-loop/switch region; other site 512564000509 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 512564000510 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 512564000511 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 512564000512 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 512564000513 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 512564000514 TM-ABC transporter signature motif; other site 512564000515 D-allose kinase; Provisional; Region: PRK09698 512564000516 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 512564000517 nucleotide binding site [chemical binding]; other site 512564000518 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 512564000519 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 512564000520 active site 512564000521 HIGH motif; other site 512564000522 nucleotide binding site [chemical binding]; other site 512564000523 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 512564000524 active site 512564000525 KMSKS motif; other site 512564000526 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 512564000527 tRNA binding surface [nucleotide binding]; other site 512564000528 anticodon binding site; other site 512564000529 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 512564000530 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 512564000531 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 512564000532 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 512564000533 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 512564000534 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 512564000535 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 512564000536 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 512564000537 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 512564000538 putative active site [active] 512564000539 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 512564000540 active site 512564000541 phosphorylation site [posttranslational modification] 512564000542 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 512564000543 active site 512564000544 P-loop; other site 512564000545 phosphorylation site [posttranslational modification] 512564000546 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 512564000547 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 512564000548 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 512564000549 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 512564000550 Ligand Binding Site [chemical binding]; other site 512564000551 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 512564000552 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 512564000553 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 512564000554 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 512564000555 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 512564000556 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 512564000557 23S rRNA binding site [nucleotide binding]; other site 512564000558 L21 binding site [polypeptide binding]; other site 512564000559 L13 binding site [polypeptide binding]; other site 512564000560 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 512564000561 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 512564000562 Ligand Binding Site [chemical binding]; other site 512564000563 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 512564000564 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 512564000565 motif 1; other site 512564000566 active site 512564000567 motif 2; other site 512564000568 motif 3; other site 512564000569 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 512564000570 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 512564000571 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 512564000572 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 512564000573 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 512564000574 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 512564000575 active site 512564000576 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 512564000577 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512564000578 Walker A/P-loop; other site 512564000579 ATP binding site [chemical binding]; other site 512564000580 Q-loop/lid; other site 512564000581 ABC transporter signature motif; other site 512564000582 Walker B; other site 512564000583 D-loop; other site 512564000584 H-loop/switch region; other site 512564000585 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 512564000586 ABC-2 type transporter; Region: ABC2_membrane; cl17235 512564000587 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 512564000588 active site 512564000589 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 512564000590 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 512564000591 HIGH motif; other site 512564000592 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 512564000593 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 512564000594 active site 512564000595 KMSKS motif; other site 512564000596 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 512564000597 tRNA binding surface [nucleotide binding]; other site 512564000598 anticodon binding site; other site 512564000599 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512564000600 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 512564000601 Walker A motif; other site 512564000602 ATP binding site [chemical binding]; other site 512564000603 Walker B motif; other site 512564000604 arginine finger; other site 512564000605 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 512564000606 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 512564000607 Amidinotransferase; Region: Amidinotransf; cl12043 512564000608 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 512564000609 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 512564000610 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 512564000611 Part of AAA domain; Region: AAA_19; pfam13245 512564000612 Family description; Region: UvrD_C_2; pfam13538 512564000613 RDD family; Region: RDD; pfam06271 512564000614 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 512564000615 active site 512564000616 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 512564000617 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 512564000618 putative dimer interface [polypeptide binding]; other site 512564000619 putative anticodon binding site; other site 512564000620 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 512564000621 motif 1; other site 512564000622 dimer interface [polypeptide binding]; other site 512564000623 active site 512564000624 motif 2; other site 512564000625 motif 3; other site 512564000626 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 512564000627 active site turn [active] 512564000628 phosphorylation site [posttranslational modification] 512564000629 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 512564000630 HPr interaction site; other site 512564000631 glycerol kinase (GK) interaction site [polypeptide binding]; other site 512564000632 active site 512564000633 phosphorylation site [posttranslational modification] 512564000634 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 512564000635 Protein of unknown function (DUF3137); Region: DUF3137; pfam11335 512564000636 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 512564000637 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 512564000638 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 512564000639 DNA binding site [nucleotide binding] 512564000640 catalytic residue [active] 512564000641 H2TH interface [polypeptide binding]; other site 512564000642 putative catalytic residues [active] 512564000643 turnover-facilitating residue; other site 512564000644 intercalation triad [nucleotide binding]; other site 512564000645 8OG recognition residue [nucleotide binding]; other site 512564000646 putative reading head residues; other site 512564000647 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 512564000648 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 512564000649 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 512564000650 Purine-nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: DeoD; COG0813 512564000651 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 512564000652 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 512564000653 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 512564000654 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 512564000655 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 512564000656 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 512564000657 intersubunit interface [polypeptide binding]; other site 512564000658 active site 512564000659 catalytic residue [active] 512564000660 Phosphomevalonate kinase; Region: P-mevalo_kinase; cl04466 512564000661 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 512564000662 Domain of unknown function(DUF2779); Region: DUF2779; pfam11074 512564000663 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 512564000664 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 512564000665 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512564000666 dimer interface [polypeptide binding]; other site 512564000667 conserved gate region; other site 512564000668 putative PBP binding loops; other site 512564000669 ABC-ATPase subunit interface; other site 512564000670 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512564000671 dimer interface [polypeptide binding]; other site 512564000672 conserved gate region; other site 512564000673 ABC-ATPase subunit interface; other site 512564000674 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512564000675 AAA domain; Region: AAA_21; pfam13304 512564000676 Walker A/P-loop; other site 512564000677 ATP binding site [chemical binding]; other site 512564000678 Q-loop/lid; other site 512564000679 ABC transporter signature motif; other site 512564000680 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 512564000681 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512564000682 ABC transporter signature motif; other site 512564000683 Walker B; other site 512564000684 D-loop; other site 512564000685 H-loop/switch region; other site 512564000686 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 512564000687 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 512564000688 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512564000689 Walker A/P-loop; other site 512564000690 ATP binding site [chemical binding]; other site 512564000691 Q-loop/lid; other site 512564000692 ABC transporter signature motif; other site 512564000693 Walker B; other site 512564000694 D-loop; other site 512564000695 H-loop/switch region; other site 512564000696 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 512564000697 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 512564000698 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 512564000699 Walker A/P-loop; other site 512564000700 ATP binding site [chemical binding]; other site 512564000701 Q-loop/lid; other site 512564000702 ABC transporter signature motif; other site 512564000703 Walker B; other site 512564000704 D-loop; other site 512564000705 H-loop/switch region; other site 512564000706 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 512564000707 Uncharacterized conserved protein [Function unknown]; Region: COG1284 512564000708 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 512564000709 hypothetical protein; Provisional; Region: PRK13671 512564000710 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 512564000711 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 512564000712 NAD binding site [chemical binding]; other site 512564000713 homodimer interface [polypeptide binding]; other site 512564000714 active site 512564000715 substrate binding site [chemical binding]; other site 512564000716 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 512564000717 active site 512564000718 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 512564000719 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 512564000720 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 512564000721 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 512564000722 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512564000723 Walker A motif; other site 512564000724 ATP binding site [chemical binding]; other site 512564000725 Walker B motif; other site 512564000726 arginine finger; other site 512564000727 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 512564000728 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 512564000729 Protein export membrane protein; Region: SecD_SecF; cl14618 512564000730 protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966 512564000731 Protein export membrane protein; Region: SecD_SecF; cl14618 512564000732 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 512564000733 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 512564000734 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 512564000735 putative active site [active] 512564000736 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 512564000737 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 512564000738 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 512564000739 active site turn [active] 512564000740 phosphorylation site [posttranslational modification] 512564000741 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 512564000742 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 512564000743 active site 512564000744 dimer interface [polypeptide binding]; other site 512564000745 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 512564000746 dimer interface [polypeptide binding]; other site 512564000747 active site 512564000748 inorganic pyrophosphatase; Provisional; Region: PRK02230 512564000749 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 512564000750 dimer interface [polypeptide binding]; other site 512564000751 substrate binding site [chemical binding]; other site 512564000752 metal binding sites [ion binding]; metal-binding site 512564000753 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 512564000754 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 512564000755 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512564000756 Walker A/P-loop; other site 512564000757 ATP binding site [chemical binding]; other site 512564000758 Q-loop/lid; other site 512564000759 ABC transporter signature motif; other site 512564000760 Walker B; other site 512564000761 D-loop; other site 512564000762 H-loop/switch region; other site 512564000763 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 512564000764 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 512564000765 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 512564000766 Walker A/P-loop; other site 512564000767 ATP binding site [chemical binding]; other site 512564000768 Q-loop/lid; other site 512564000769 ABC transporter signature motif; other site 512564000770 Walker B; other site 512564000771 D-loop; other site 512564000772 H-loop/switch region; other site 512564000773 glycyl-tRNA synthetase; Provisional; Region: PRK04173 512564000774 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 512564000775 motif 1; other site 512564000776 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 512564000777 active site 512564000778 motif 2; other site 512564000779 motif 3; other site 512564000780 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 512564000781 anticodon binding site; other site 512564000782 DNA primase, catalytic core; Region: dnaG; TIGR01391 512564000783 CHC2 zinc finger; Region: zf-CHC2; pfam01807 512564000784 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 512564000785 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 512564000786 active site 512564000787 metal binding site [ion binding]; metal-binding site 512564000788 interdomain interaction site; other site 512564000789 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 512564000790 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 512564000791 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 512564000792 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 512564000793 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 512564000794 DNA binding residues [nucleotide binding] 512564000795 Uncharacterized conserved protein [Function unknown]; Region: COG0327 512564000796 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 512564000797 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 512564000798 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 512564000799 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 512564000800 putative active site [active] 512564000801 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 512564000802 active site 512564000803 catalytic triad [active] 512564000804 oxyanion hole [active] 512564000805 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 512564000806 Catalytic domain of Protein Kinases; Region: PKc; cd00180 512564000807 active site 512564000808 ATP binding site [chemical binding]; other site 512564000809 substrate binding site [chemical binding]; other site 512564000810 activation loop (A-loop); other site 512564000811 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 512564000812 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 512564000813 active site 512564000814 trimer interface [polypeptide binding]; other site 512564000815 allosteric site; other site 512564000816 active site lid [active] 512564000817 hexamer (dimer of trimers) interface [polypeptide binding]; other site 512564000818 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 512564000819 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 512564000820 active site 512564000821 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 512564000822 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 512564000823 putative active site [active] 512564000824 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 512564000825 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 512564000826 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 512564000827 putative active site [active] 512564000828 catalytic site [active] 512564000829 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 512564000830 putative active site [active] 512564000831 catalytic site [active] 512564000832 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 512564000833 dimerization domain swap beta strand [polypeptide binding]; other site 512564000834 regulatory protein interface [polypeptide binding]; other site 512564000835 active site 512564000836 regulatory phosphorylation site [posttranslational modification]; other site 512564000837 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 512564000838 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512564000839 dimer interface [polypeptide binding]; other site 512564000840 conserved gate region; other site 512564000841 putative PBP binding loops; other site 512564000842 ABC-ATPase subunit interface; other site 512564000843 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 512564000844 FMN binding site [chemical binding]; other site 512564000845 dimer interface [polypeptide binding]; other site 512564000846 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 512564000847 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 512564000848 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 512564000849 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 512564000850 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512564000851 motif II; other site 512564000852 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 512564000853 Ion channel; Region: Ion_trans_2; pfam07885 512564000854 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 512564000855 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 512564000856 catalytic site [active] 512564000857 G-X2-G-X-G-K; other site 512564000858 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 512564000859 active site 512564000860 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 512564000861 Catalytic domain of Protein Kinases; Region: PKc; cd00180 512564000862 active site 512564000863 ATP binding site [chemical binding]; other site 512564000864 substrate binding site [chemical binding]; other site 512564000865 activation loop (A-loop); other site 512564000866 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 512564000867 Predicted GTPases [General function prediction only]; Region: COG1162 512564000868 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 512564000869 RNA binding site [nucleotide binding]; other site 512564000870 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 512564000871 GTPase/Zn-binding domain interface [polypeptide binding]; other site 512564000872 GTP/Mg2+ binding site [chemical binding]; other site 512564000873 G4 box; other site 512564000874 G5 box; other site 512564000875 G1 box; other site 512564000876 Switch I region; other site 512564000877 G2 box; other site 512564000878 G3 box; other site 512564000879 Switch II region; other site 512564000880 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 512564000881 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 512564000882 substrate binding site [chemical binding]; other site 512564000883 hexamer interface [polypeptide binding]; other site 512564000884 metal binding site [ion binding]; metal-binding site 512564000885 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 512564000886 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 512564000887 cofactor binding site; other site 512564000888 DNA binding site [nucleotide binding] 512564000889 substrate interaction site [chemical binding]; other site 512564000890 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 512564000891 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 512564000892 putative active site [active] 512564000893 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 512564000894 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 512564000895 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 512564000896 dimer interface [polypeptide binding]; other site 512564000897 active site 512564000898 glycine-pyridoxal phosphate binding site [chemical binding]; other site 512564000899 folate binding site [chemical binding]; other site 512564000900 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 512564000901 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 512564000902 putative tRNA-binding site [nucleotide binding]; other site 512564000903 B3/4 domain; Region: B3_4; pfam03483 512564000904 tRNA synthetase B5 domain; Region: B5; smart00874 512564000905 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 512564000906 dimer interface [polypeptide binding]; other site 512564000907 motif 1; other site 512564000908 motif 3; other site 512564000909 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 512564000910 ligand binding site [chemical binding]; other site 512564000911 active site 512564000912 UGI interface [polypeptide binding]; other site 512564000913 catalytic site [active] 512564000914 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 512564000915 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 512564000916 dimer interface [polypeptide binding]; other site 512564000917 motif 1; other site 512564000918 active site 512564000919 motif 2; other site 512564000920 motif 3; other site 512564000921 recombination factor protein RarA; Reviewed; Region: PRK13342 512564000922 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512564000923 Walker A motif; other site 512564000924 ATP binding site [chemical binding]; other site 512564000925 Walker B motif; other site 512564000926 arginine finger; other site 512564000927 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 512564000928 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 512564000929 Protein of unknown function DUF262; Region: DUF262; pfam03235 512564000930 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 512564000931 Transglutaminase/protease-like homologues; Region: TGc; smart00460 512564000932 Competence protein; Region: Competence; pfam03772 512564000933 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 512564000934 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 512564000935 core dimer interface [polypeptide binding]; other site 512564000936 peripheral dimer interface [polypeptide binding]; other site 512564000937 L10 interface [polypeptide binding]; other site 512564000938 L11 interface [polypeptide binding]; other site 512564000939 putative EF-Tu interaction site [polypeptide binding]; other site 512564000940 putative EF-G interaction site [polypeptide binding]; other site 512564000941 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 512564000942 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 512564000943 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 512564000944 RPB1 interaction site [polypeptide binding]; other site 512564000945 RPB10 interaction site [polypeptide binding]; other site 512564000946 RPB11 interaction site [polypeptide binding]; other site 512564000947 RPB3 interaction site [polypeptide binding]; other site 512564000948 RPB12 interaction site [polypeptide binding]; other site 512564000949 dUTPase; Region: dUTPase_2; pfam08761 512564000950 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 512564000951 active site 512564000952 homodimer interface [polypeptide binding]; other site 512564000953 metal binding site [ion binding]; metal-binding site 512564000954 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 512564000955 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 512564000956 cofactor binding site; other site 512564000957 DNA binding site [nucleotide binding] 512564000958 substrate interaction site [chemical binding]; other site 512564000959 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 512564000960 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 512564000961 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 512564000962 substrate binding site [chemical binding]; other site 512564000963 ATP binding site [chemical binding]; other site 512564000964 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 512564000965 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 512564000966 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 512564000967 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512564000968 dimer interface [polypeptide binding]; other site 512564000969 conserved gate region; other site 512564000970 putative PBP binding loops; other site 512564000971 ABC-ATPase subunit interface; other site 512564000972 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 512564000973 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 512564000974 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512564000975 dimer interface [polypeptide binding]; other site 512564000976 conserved gate region; other site 512564000977 putative PBP binding loops; other site 512564000978 ABC-ATPase subunit interface; other site 512564000979 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 512564000980 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 512564000981 Walker A/P-loop; other site 512564000982 ATP binding site [chemical binding]; other site 512564000983 Q-loop/lid; other site 512564000984 ABC transporter signature motif; other site 512564000985 Walker B; other site 512564000986 D-loop; other site 512564000987 H-loop/switch region; other site 512564000988 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 512564000989 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512564000990 Walker A/P-loop; other site 512564000991 ATP binding site [chemical binding]; other site 512564000992 AAA domain; Region: AAA_21; pfam13304 512564000993 Q-loop/lid; other site 512564000994 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 512564000995 ABC transporter signature motif; other site 512564000996 Walker B; other site 512564000997 D-loop; other site 512564000998 H-loop/switch region; other site 512564000999 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 512564001000 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 512564001001 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 512564001002 oligomer interface [polypeptide binding]; other site 512564001003 active site 512564001004 metal binding site [ion binding]; metal-binding site 512564001005 Uncharacterized protein family (UPF0154); Region: UPF0154; cl01536 512564001006 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 512564001007 V-type ATP synthase subunit I; Validated; Region: PRK05771 512564001008 Cation transport protein; Region: TrkH; cl17365 512564001009 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 512564001010 rRNA interaction site [nucleotide binding]; other site 512564001011 S8 interaction site; other site 512564001012 putative laminin-1 binding site; other site 512564001013 elongation factor Ts; Provisional; Region: tsf; PRK09377 512564001014 UBA/TS-N domain; Region: UBA; pfam00627 512564001015 Elongation factor TS; Region: EF_TS; pfam00889 512564001016 Elongation factor TS; Region: EF_TS; pfam00889 512564001017 elongation factor P; Validated; Region: PRK00529 512564001018 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 512564001019 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 512564001020 RNA binding site [nucleotide binding]; other site 512564001021 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 512564001022 RNA binding site [nucleotide binding]; other site 512564001023 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 512564001024 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 512564001025 active site 512564001026 substrate binding site [chemical binding]; other site 512564001027 metal binding site [ion binding]; metal-binding site 512564001028 transcription antitermination factor NusB; Region: nusB; TIGR01951 512564001029 putative RNA binding site [nucleotide binding]; other site 512564001030 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 512564001031 active site 512564001032 trimerization site [polypeptide binding]; other site 512564001033 F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) [Energy production and conversion]; Region: AtpC; COG0355 512564001034 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 512564001035 gamma subunit interface [polypeptide binding]; other site 512564001036 epsilon subunit interface [polypeptide binding]; other site 512564001037 LBP interface [polypeptide binding]; other site 512564001038 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 512564001039 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 512564001040 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 512564001041 alpha subunit interaction interface [polypeptide binding]; other site 512564001042 Walker A motif; other site 512564001043 ATP binding site [chemical binding]; other site 512564001044 Walker B motif; other site 512564001045 inhibitor binding site; inhibition site 512564001046 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 512564001047 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 512564001048 core domain interface [polypeptide binding]; other site 512564001049 delta subunit interface [polypeptide binding]; other site 512564001050 epsilon subunit interface [polypeptide binding]; other site 512564001051 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 512564001052 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 512564001053 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 512564001054 beta subunit interaction interface [polypeptide binding]; other site 512564001055 Walker A motif; other site 512564001056 ATP binding site [chemical binding]; other site 512564001057 Walker B motif; other site 512564001058 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 512564001059 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 512564001060 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 512564001061 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 512564001062 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 512564001063 ATP synthase subunit C; Region: ATP-synt_C; cl00466 512564001064 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 512564001065 Domain of unknown function (DUF386); Region: DUF386; cl01047 512564001066 RmuC family; Region: RmuC; pfam02646 512564001067 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 512564001068 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 512564001069 catalytic residue [active] 512564001070 CTP:phosphocholine cytidylyltransferase involved in choline phosphorylation for cell surface LPS epitopes [Cell envelope biogenesis, outer membrane]; Region: LicC; COG4750 512564001071 LicD family; Region: LicD; pfam04991 512564001072 histidyl-tRNA synthetase; Region: hisS; TIGR00442 512564001073 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 512564001074 dimer interface [polypeptide binding]; other site 512564001075 motif 1; other site 512564001076 active site 512564001077 motif 2; other site 512564001078 motif 3; other site 512564001079 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 512564001080 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 512564001081 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 512564001082 active site 512564001083 dimer interface [polypeptide binding]; other site 512564001084 motif 1; other site 512564001085 motif 2; other site 512564001086 motif 3; other site 512564001087 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 512564001088 anticodon binding site; other site 512564001089 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 512564001090 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 512564001091 active site 512564001092 HIGH motif; other site 512564001093 dimer interface [polypeptide binding]; other site 512564001094 KMSKS motif; other site 512564001095 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 512564001096 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 512564001097 MgtE intracellular N domain; Region: MgtE_N; pfam03448 512564001098 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 512564001099 Divalent cation transporter; Region: MgtE; pfam01769 512564001100 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12903 512564001101 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 512564001102 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752 512564001103 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cl17706 512564001104 substrate binding site [chemical binding]; other site 512564001105 catalytic residues [active] 512564001106 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 512564001107 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 512564001108 substrate binding site [chemical binding]; other site 512564001109 ATP binding site [chemical binding]; other site 512564001110 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 512564001111 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 512564001112 active site 512564001113 intersubunit interface [polypeptide binding]; other site 512564001114 catalytic residue [active] 512564001115 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 512564001116 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 512564001117 NADP binding site [chemical binding]; other site 512564001118 homodimer interface [polypeptide binding]; other site 512564001119 active site 512564001120 Preprotein translocase subunit; Region: YajC; cl00806 512564001121 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 512564001122 active pocket/dimerization site; other site 512564001123 active site 512564001124 phosphorylation site [posttranslational modification] 512564001125 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 512564001126 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 512564001127 active site 512564001128 phosphorylation site [posttranslational modification] 512564001129 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 512564001130 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 512564001131 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 512564001132 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 512564001133 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 512564001134 putative active site [active] 512564001135 Putative peptidase (DUF31); Region: DUF31; pfam01732 512564001136 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 512564001137 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 512564001138 Protein of unknown function DUF262; Region: DUF262; pfam03235 512564001139 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 512564001140 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 512564001141 GIY-YIG motif/motif A; other site 512564001142 active site 512564001143 catalytic site [active] 512564001144 putative DNA binding site [nucleotide binding]; other site 512564001145 metal binding site [ion binding]; metal-binding site 512564001146 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 512564001147 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 512564001148 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 512564001149 tetramer interface [polypeptide binding]; other site 512564001150 TPP-binding site [chemical binding]; other site 512564001151 heterodimer interface [polypeptide binding]; other site 512564001152 phosphorylation loop region [posttranslational modification] 512564001153 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 512564001154 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 512564001155 alpha subunit interface [polypeptide binding]; other site 512564001156 TPP binding site [chemical binding]; other site 512564001157 heterodimer interface [polypeptide binding]; other site 512564001158 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 512564001159 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 512564001160 e3 binding domain; Region: E3_binding; pfam02817 512564001161 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 512564001162 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 512564001163 E3 interaction surface; other site 512564001164 lipoyl attachment site [posttranslational modification]; other site 512564001165 Predicted oxidoreductase [General function prediction only]; Region: COG3573 512564001166 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 512564001167 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 512564001168 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 512564001169 Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539 512564001170 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 512564001171 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 512564001172 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 512564001173 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 512564001174 Walker A/P-loop; other site 512564001175 ATP binding site [chemical binding]; other site 512564001176 Q-loop/lid; other site 512564001177 ABC transporter signature motif; other site 512564001178 Walker B; other site 512564001179 D-loop; other site 512564001180 H-loop/switch region; other site 512564001181 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 512564001182 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 512564001183 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 512564001184 TM-ABC transporter signature motif; other site 512564001185 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 512564001186 active site 512564001187 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 512564001188 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 512564001189 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 512564001190 23S rRNA interface [nucleotide binding]; other site 512564001191 L3 interface [polypeptide binding]; other site 512564001192 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 512564001193 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 512564001194 nucleotide binding site [chemical binding]; other site 512564001195 SulA interaction site; other site 512564001196 MraW methylase family; Region: Methyltransf_5; cl17771 512564001197 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 512564001198 cell division protein MraZ; Reviewed; Region: PRK00326 512564001199 MraZ protein; Region: MraZ; pfam02381 512564001200 MraZ protein; Region: MraZ; pfam02381 512564001201 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 512564001202 TrkA-N domain; Region: TrkA_N; pfam02254 512564001203 TrkA-C domain; Region: TrkA_C; pfam02080 512564001204 dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364 512564001205 DAK2 domain; Region: Dak2; cl03685 512564001206 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 512564001207 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 512564001208 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 512564001209 DHH family; Region: DHH; pfam01368 512564001210 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 512564001211 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 512564001212 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 512564001213 replicative DNA helicase; Region: DnaB; TIGR00665 512564001214 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 512564001215 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 512564001216 Walker A motif; other site 512564001217 ATP binding site [chemical binding]; other site 512564001218 Walker B motif; other site 512564001219 DNA binding loops [nucleotide binding] 512564001220 Domain of unknown function DUF21; Region: DUF21; pfam01595 512564001221 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 512564001222 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 512564001223 putative catalytic site [active] 512564001224 putative metal binding site [ion binding]; other site 512564001225 putative phosphate binding site [ion binding]; other site 512564001226 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 512564001227 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 512564001228 active site 512564001229 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 512564001230 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 512564001231 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 512564001232 dimer interface [polypeptide binding]; other site 512564001233 ssDNA binding site [nucleotide binding]; other site 512564001234 tetramer (dimer of dimers) interface [polypeptide binding]; other site 512564001235 DNA topoisomerase I; Validated; Region: PRK05582 512564001236 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 512564001237 active site 512564001238 interdomain interaction site; other site 512564001239 putative metal-binding site [ion binding]; other site 512564001240 nucleotide binding site [chemical binding]; other site 512564001241 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 512564001242 domain I; other site 512564001243 DNA binding groove [nucleotide binding] 512564001244 phosphate binding site [ion binding]; other site 512564001245 domain II; other site 512564001246 domain III; other site 512564001247 nucleotide binding site [chemical binding]; other site 512564001248 catalytic site [active] 512564001249 domain IV; other site 512564001250 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 512564001251 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 512564001252 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 512564001253 active site 512564001254 DNA binding site [nucleotide binding] 512564001255 putative nicotinate-nucleotide adenylyltransferase; Validated; Region: nadD; PRK07152 512564001256 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 512564001257 active site 512564001258 (T/H)XGH motif; other site 512564001259 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 512564001260 Zn2+ binding site [ion binding]; other site 512564001261 Mg2+ binding site [ion binding]; other site 512564001262 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 512564001263 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 512564001264 RNA binding surface [nucleotide binding]; other site 512564001265 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 512564001266 active site 512564001267 Phosphoglycerate kinase; Region: PGK; pfam00162 512564001268 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 512564001269 substrate binding site [chemical binding]; other site 512564001270 hinge regions; other site 512564001271 ADP binding site [chemical binding]; other site 512564001272 catalytic site [active] 512564001273 AAA-like domain; Region: AAA_10; pfam12846 512564001274 Domain of unknown function DUF87; Region: DUF87; pfam01935 512564001275 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 512564001276 generic binding surface II; other site 512564001277 generic binding surface I; other site 512564001278 DNA protecting protein DprA; Region: dprA; TIGR00732 512564001279 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 512564001280 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 512564001281 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 512564001282 active site turn [active] 512564001283 phosphorylation site [posttranslational modification] 512564001284 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 512564001285 Part of AAA domain; Region: AAA_19; pfam13245 512564001286 AAA domain; Region: AAA_12; pfam13087 512564001287 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 512564001288 dimerization interface [polypeptide binding]; other site 512564001289 putative DNA binding site [nucleotide binding]; other site 512564001290 putative Zn2+ binding site [ion binding]; other site 512564001291 6-phosphofructokinase; Provisional; Region: PRK03202 512564001292 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 512564001293 active site 512564001294 ADP/pyrophosphate binding site [chemical binding]; other site 512564001295 dimerization interface [polypeptide binding]; other site 512564001296 allosteric effector site; other site 512564001297 fructose-1,6-bisphosphate binding site; other site 512564001298 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 512564001299 active site 512564001300 substrate binding site [chemical binding]; other site 512564001301 ATP binding site [chemical binding]; other site 512564001302 Phosphotransferase enzyme family; Region: APH; pfam01636 512564001303 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 512564001304 active site 512564001305 ATP binding site [chemical binding]; other site 512564001306 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 512564001307 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512564001308 Walker A/P-loop; other site 512564001309 ATP binding site [chemical binding]; other site 512564001310 Q-loop/lid; other site 512564001311 ABC transporter signature motif; other site 512564001312 Walker B; other site 512564001313 D-loop; other site 512564001314 H-loop/switch region; other site 512564001315 High affinity transport system protein p37; Region: Mycoplasma_p37; pfam06646 512564001316 azoreductase; Reviewed; Region: PRK01355 512564001317 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 512564001318 putative active site pocket [active] 512564001319 dimerization interface [polypeptide binding]; other site 512564001320 putative catalytic residue [active] 512564001321 GTPase CgtA; Reviewed; Region: obgE; PRK12297 512564001322 GTP1/OBG; Region: GTP1_OBG; pfam01018 512564001323 Obg GTPase; Region: Obg; cd01898 512564001324 G1 box; other site 512564001325 GTP/Mg2+ binding site [chemical binding]; other site 512564001326 Switch I region; other site 512564001327 G2 box; other site 512564001328 G3 box; other site 512564001329 Switch II region; other site 512564001330 G4 box; other site 512564001331 G5 box; other site 512564001332 Obg family GTPase CgtA, C-terminal extension; Region: Obg_CgtA_exten; TIGR03595 512564001333 PhoU domain; Region: PhoU; pfam01895 512564001334 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 512564001335 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 512564001336 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 512564001337 Walker A/P-loop; other site 512564001338 ATP binding site [chemical binding]; other site 512564001339 Q-loop/lid; other site 512564001340 ABC transporter signature motif; other site 512564001341 Walker B; other site 512564001342 D-loop; other site 512564001343 H-loop/switch region; other site 512564001344 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 512564001345 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512564001346 dimer interface [polypeptide binding]; other site 512564001347 conserved gate region; other site 512564001348 putative PBP binding loops; other site 512564001349 ABC-ATPase subunit interface; other site 512564001350 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 512564001351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512564001352 dimer interface [polypeptide binding]; other site 512564001353 conserved gate region; other site 512564001354 putative PBP binding loops; other site 512564001355 ABC-ATPase subunit interface; other site 512564001356 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 512564001357 Mycoplasma virulence family signal region; Region: Myco_arth_vir_N; TIGR02184 512564001358 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 512564001359 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512564001360 active site 512564001361 motif I; other site 512564001362 motif II; other site 512564001363 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 512564001364 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 512564001365 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 512564001366 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 512564001367 Walker A/P-loop; other site 512564001368 ATP binding site [chemical binding]; other site 512564001369 Q-loop/lid; other site 512564001370 ABC transporter signature motif; other site 512564001371 Walker B; other site 512564001372 D-loop; other site 512564001373 H-loop/switch region; other site 512564001374 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 512564001375 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 512564001376 Walker A/P-loop; other site 512564001377 ATP binding site [chemical binding]; other site 512564001378 ABC transporter; Region: ABC_tran; pfam00005 512564001379 Q-loop/lid; other site 512564001380 ABC transporter signature motif; other site 512564001381 Walker B; other site 512564001382 D-loop; other site 512564001383 H-loop/switch region; other site 512564001384 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 512564001385 phosphopentomutase; Provisional; Region: PRK05362 512564001386 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 512564001387 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 512564001388 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 512564001389 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 512564001390 GatB domain; Region: GatB_Yqey; smart00845 512564001391 amidase; Provisional; Region: PRK07139 512564001392 indole-3-acetamide amidohydrolase; Region: PLN02722 512564001393 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 512564001394 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 512564001395 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 512564001396 active site 512564001397 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 512564001398 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 512564001399 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 512564001400 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 512564001401 putative acyl-acceptor binding pocket; other site 512564001402 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 512564001403 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 512564001404 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 512564001405 HIGH motif; other site 512564001406 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 512564001407 active site 512564001408 KMSKS motif; other site 512564001409 pyruvate kinase; Provisional; Region: PRK05826 512564001410 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 512564001411 domain interfaces; other site 512564001412 active site 512564001413 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 512564001414 G1 box; other site 512564001415 GTP/Mg2+ binding site [chemical binding]; other site 512564001416 Switch I region; other site 512564001417 G2 box; other site 512564001418 G3 box; other site 512564001419 Switch II region; other site 512564001420 G4 box; other site 512564001421 G5 box; other site 512564001422 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK13964 512564001423 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 512564001424 active site 512564001425 nucleotide binding site [chemical binding]; other site 512564001426 HIGH motif; other site 512564001427 KMSKS motif; other site 512564001428 acetate kinase; Provisional; Region: PRK07157 512564001429 propionate/acetate kinase; Provisional; Region: PRK12379 512564001430 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 512564001431 Endonuclease I; Region: Endonuclease_1; cl01003 512564001432 aromatic cluster surface protein; Region: aro_clust_Mycop; TIGR04313 512564001433 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 512564001434 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 512564001435 Walker A/P-loop; other site 512564001436 ATP binding site [chemical binding]; other site 512564001437 Q-loop/lid; other site 512564001438 ABC transporter signature motif; other site 512564001439 Walker B; other site 512564001440 D-loop; other site 512564001441 H-loop/switch region; other site 512564001442 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 512564001443 aromatic cluster surface protein; Region: aro_clust_Mycop; TIGR04313 512564001444 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 512564001445 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 512564001446 NAD(P) binding site [chemical binding]; other site 512564001447 catalytic residues [active] 512564001448 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 512564001449 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 512564001450 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 512564001451 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14183 512564001452 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 512564001453 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 512564001454 homodimer interface [polypeptide binding]; other site 512564001455 NADP binding site [chemical binding]; other site 512564001456 substrate binding site [chemical binding]; other site 512564001457 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 512564001458 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 512564001459 active site 512564001460 HIGH motif; other site 512564001461 nucleotide binding site [chemical binding]; other site 512564001462 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 512564001463 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 512564001464 active site 512564001465 KMSKS motif; other site 512564001466 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 512564001467 tRNA binding surface [nucleotide binding]; other site 512564001468 anticodon binding site; other site 512564001469 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 512564001470 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512564001471 Walker B; other site 512564001472 D-loop; other site 512564001473 H-loop/switch region; other site 512564001474 hypothetical protein; Provisional; Region: PRK09609 512564001475 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 512564001476 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 512564001477 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 512564001478 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 512564001479 NAD synthetase; Provisional; Region: PRK13980 512564001480 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 512564001481 homodimer interface [polypeptide binding]; other site 512564001482 NAD binding pocket [chemical binding]; other site 512564001483 ATP binding pocket [chemical binding]; other site 512564001484 Mg binding site [ion binding]; other site 512564001485 active-site loop [active] 512564001486 hypothetical protein; Validated; Region: PRK00110 512564001487 ZIP Zinc transporter; Region: Zip; pfam02535 512564001488 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 512564001489 DNA polymerase III DnaE; Validated; Region: dnaE; PRK07135 512564001490 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 512564001491 active site 512564001492 PHP Thumb interface [polypeptide binding]; other site 512564001493 5'-3' exonuclease; Provisional; Region: PRK14976 512564001494 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 512564001495 active site 512564001496 metal binding site 1 [ion binding]; metal-binding site 512564001497 putative 5' ssDNA interaction site; other site 512564001498 metal binding site 3; metal-binding site 512564001499 metal binding site 2 [ion binding]; metal-binding site 512564001500 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 512564001501 putative DNA binding site [nucleotide binding]; other site 512564001502 putative metal binding site [ion binding]; other site 512564001503 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 512564001504 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 512564001505 active site 512564001506 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 512564001507 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512564001508 Walker A motif; other site 512564001509 ATP binding site [chemical binding]; other site 512564001510 Walker B motif; other site 512564001511 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 512564001512 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 512564001513 putative active site [active] 512564001514 substrate binding site [chemical binding]; other site 512564001515 putative cosubstrate binding site; other site 512564001516 catalytic site [active] 512564001517 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 512564001518 substrate binding site [chemical binding]; other site 512564001519 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 512564001520 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 512564001521 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 512564001522 thymidine kinase; Provisional; Region: PRK04296 512564001523 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 512564001524 DNA methylase; Region: N6_N4_Mtase; pfam01555 512564001525 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 512564001526 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 512564001527 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 512564001528 RNA binding surface [nucleotide binding]; other site 512564001529 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 512564001530 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 512564001531 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 512564001532 putative phosphoketolase; Provisional; Region: PRK05261 512564001533 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 512564001534 TPP-binding site; other site 512564001535 XFP C-terminal domain; Region: XFP_C; pfam09363 512564001536 UDP-galactopyranose mutase; Region: UDP-GALP_mutase; TIGR00031 512564001537 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 512564001538 UDP-galactopyranose mutase; Region: GLF; pfam03275 512564001539 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 512564001540 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 512564001541 DXD motif; other site 512564001542 GrpE; Region: GrpE; pfam01025 512564001543 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 512564001544 dimer interface [polypeptide binding]; other site 512564001545 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 512564001546 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 512564001547 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 512564001548 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl17885 512564001549 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 512564001550 active site turn [active] 512564001551 phosphorylation site [posttranslational modification] 512564001552 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 512564001553 HPr interaction site; other site 512564001554 glycerol kinase (GK) interaction site [polypeptide binding]; other site 512564001555 active site 512564001556 phosphorylation site [posttranslational modification] 512564001557 peptide chain release factor 1; Validated; Region: prfA; PRK00591 512564001558 This domain is found in peptide chain release factors; Region: PCRF; smart00937 512564001559 RF-1 domain; Region: RF-1; pfam00472 512564001560 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 512564001561 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512564001562 S-adenosylmethionine binding site [chemical binding]; other site 512564001563 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 512564001564 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 512564001565 TPP-binding site [chemical binding]; other site 512564001566 dimer interface [polypeptide binding]; other site 512564001567 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 512564001568 PYR/PP interface [polypeptide binding]; other site 512564001569 dimer interface [polypeptide binding]; other site 512564001570 TPP binding site [chemical binding]; other site 512564001571 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 512564001572 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 512564001573 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 512564001574 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 512564001575 RNA binding site [nucleotide binding]; other site 512564001576 Nuclease-related domain; Region: NERD; pfam08378 512564001577 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 512564001578 amphipathic channel; other site 512564001579 Asn-Pro-Ala signature motifs; other site 512564001580 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 512564001581 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 512564001582 putative ligand binding site [chemical binding]; other site 512564001583 putative NAD binding site [chemical binding]; other site 512564001584 catalytic site [active] 512564001585 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 512564001586 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 512564001587 NAD binding site [chemical binding]; other site 512564001588 substrate binding site [chemical binding]; other site 512564001589 catalytic Zn binding site [ion binding]; other site 512564001590 tetramer interface [polypeptide binding]; other site 512564001591 structural Zn binding site [ion binding]; other site 512564001592 DNA protecting protein DprA; Region: dprA; TIGR00732 512564001593 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 512564001594 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 512564001595 Uncharacterized conserved protein [Function unknown]; Region: COG1284 512564001596 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 512564001597 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 512564001598 methionine sulfoxide reductase A; Provisional; Region: PRK14054 512564001599 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 512564001600 mRNA/rRNA interface [nucleotide binding]; other site 512564001601 50S ribosomal protein L11/unknown domain fusion protein; Provisional; Region: PRK14539 512564001602 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 512564001603 23S rRNA interface [nucleotide binding]; other site 512564001604 L7/L12 interface [polypeptide binding]; other site 512564001605 putative thiostrepton binding site; other site 512564001606 L25 interface [polypeptide binding]; other site 512564001607 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 512564001608 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 512564001609 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 512564001610 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 512564001611 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 512564001612 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 512564001613 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 512564001614 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 512564001615 Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: CysS; COG0215 512564001616 active site 512564001617 HIGH motif; other site 512564001618 nucleotide binding site [chemical binding]; other site 512564001619 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 512564001620 active site 512564001621 KMSKS motif; other site 512564001622 Amino acid permease; Region: AA_permease_2; pfam13520 512564001623 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 512564001624 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 512564001625 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 512564001626 intersubunit interface [polypeptide binding]; other site 512564001627 active site 512564001628 zinc binding site [ion binding]; other site 512564001629 Na+ binding site [ion binding]; other site 512564001630 Staphylococcal nuclease homologues; Region: SNc; smart00318 512564001631 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 512564001632 Catalytic site; other site 512564001633 Putative peptidase (DUF31); Region: DUF31; pfam01732 512564001634 Putative peptidase (DUF31); Region: DUF31; pfam01732 512564001635 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 512564001636 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 512564001637 active site 512564001638 uracil binding [chemical binding]; other site 512564001639 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 512564001640 Walker A/P-loop; other site 512564001641 ATP binding site [chemical binding]; other site 512564001642 Q-loop/lid; other site 512564001643 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 512564001644 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 512564001645 ABC transporter signature motif; other site 512564001646 Walker B; other site 512564001647 D-loop; other site 512564001648 H-loop/switch region; other site 512564001649 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 512564001650 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 512564001651 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 512564001652 Walker A/P-loop; other site 512564001653 ATP binding site [chemical binding]; other site 512564001654 Q-loop/lid; other site 512564001655 ABC transporter signature motif; other site 512564001656 Walker B; other site 512564001657 D-loop; other site 512564001658 H-loop/switch region; other site 512564001659 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 512564001660 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 512564001661 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512564001662 dimer interface [polypeptide binding]; other site 512564001663 conserved gate region; other site 512564001664 putative PBP binding loops; other site 512564001665 ABC-ATPase subunit interface; other site 512564001666 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 512564001667 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512564001668 dimer interface [polypeptide binding]; other site 512564001669 conserved gate region; other site 512564001670 putative PBP binding loops; other site 512564001671 ABC-ATPase subunit interface; other site 512564001672 oligoendopeptidase F; Region: pepF; TIGR00181 512564001673 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 512564001674 active site 512564001675 Zn binding site [ion binding]; other site 512564001676 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 512564001677 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 512564001678 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 512564001679 active site 512564001680 HIGH motif; other site 512564001681 KMSK motif region; other site 512564001682 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 512564001683 tRNA binding surface [nucleotide binding]; other site 512564001684 anticodon binding site; other site 512564001685 large tegument protein UL36; Provisional; Region: PHA03247 512564001686 Amino acid permease; Region: AA_permease_2; pfam13520 512564001687 carbamate kinase; Reviewed; Region: PRK12686 512564001688 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 512564001689 putative substrate binding site [chemical binding]; other site 512564001690 nucleotide binding site [chemical binding]; other site 512564001691 nucleotide binding site [chemical binding]; other site 512564001692 homodimer interface [polypeptide binding]; other site 512564001693 ornithine carbamoyltransferase; Validated; Region: PRK02102 512564001694 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 512564001695 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 512564001696 Amidinotransferase; Region: Amidinotransf; cl12043 512564001697 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 512564001698 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 512564001699 oligomer interface [polypeptide binding]; other site 512564001700 active site 512564001701 metal binding site [ion binding]; metal-binding site 512564001702 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 512564001703 Methyltransferase domain; Region: Methyltransf_26; pfam13659 512564001704 DNA methylase; Region: N6_N4_Mtase; pfam01555 512564001705 Chromate transporter; Region: Chromate_transp; pfam02417 512564001706 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 512564001707 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 512564001708 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 512564001709 IHF dimer interface [polypeptide binding]; other site 512564001710 IHF - DNA interface [nucleotide binding]; other site 512564001711 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 512564001712 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 512564001713 CAP-like domain; other site 512564001714 active site 512564001715 primary dimer interface [polypeptide binding]; other site 512564001716 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 512564001717 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 512564001718 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512564001719 S-adenosylmethionine binding site [chemical binding]; other site 512564001720 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 512564001721 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 512564001722 interface (dimer of trimers) [polypeptide binding]; other site 512564001723 Substrate-binding/catalytic site; other site 512564001724 Zn-binding sites [ion binding]; other site 512564001725 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 512564001726 excinuclease ABC subunit B; Provisional; Region: PRK05298 512564001727 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 512564001728 ATP binding site [chemical binding]; other site 512564001729 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 512564001730 nucleotide binding region [chemical binding]; other site 512564001731 ATP-binding site [chemical binding]; other site 512564001732 Ultra-violet resistance protein B; Region: UvrB; pfam12344 512564001733 UvrB/uvrC motif; Region: UVR; pfam02151 512564001734 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 512564001735 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 512564001736 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 512564001737 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 512564001738 HPr kinase/phosphorylase; Provisional; Region: PRK05428 512564001739 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 512564001740 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 512564001741 Hpr binding site; other site 512564001742 active site 512564001743 homohexamer subunit interaction site [polypeptide binding]; other site 512564001744 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 512564001745 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 512564001746 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 512564001747 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 512564001748 (R)-2-Hydroxyglutarate Dehydrogenase and related dehydrogenases, NAD-binding and catalytic domains; Region: HGDH_like; cd12184 512564001749 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 512564001750 putative homodimer interface [polypeptide binding]; other site 512564001751 putative ligand binding site [chemical binding]; other site 512564001752 putative NAD binding site [chemical binding]; other site 512564001753 catalytic site [active] 512564001754 NPCBM/NEW2 domain; Region: NPCBM; cl07060 512564001755 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 512564001756 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 512564001757 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 512564001758 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 512564001759 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 512564001760 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 512564001761 ATP binding site [chemical binding]; other site 512564001762 Mg2+ binding site [ion binding]; other site 512564001763 G-X-G motif; other site 512564001764 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 512564001765 anchoring element; other site 512564001766 dimer interface [polypeptide binding]; other site 512564001767 ATP binding site [chemical binding]; other site 512564001768 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 512564001769 active site 512564001770 putative metal-binding site [ion binding]; other site 512564001771 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 512564001772 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 512564001773 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 512564001774 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 512564001775 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 512564001776 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512564001777 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 512564001778 P loop; other site 512564001779 Walker A/P-loop; other site 512564001780 ATP binding site [chemical binding]; other site 512564001781 GTP binding site [chemical binding]; other site 512564001782 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283 512564001783 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 512564001784 CMP-binding site; other site 512564001785 The sites determining sugar specificity; other site 512564001786 GTP-binding protein Der; Reviewed; Region: PRK00093 512564001787 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 512564001788 G1 box; other site 512564001789 GTP/Mg2+ binding site [chemical binding]; other site 512564001790 Switch I region; other site 512564001791 G2 box; other site 512564001792 Switch II region; other site 512564001793 G3 box; other site 512564001794 G4 box; other site 512564001795 G5 box; other site 512564001796 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 512564001797 G1 box; other site 512564001798 GTP/Mg2+ binding site [chemical binding]; other site 512564001799 Switch I region; other site 512564001800 G2 box; other site 512564001801 G3 box; other site 512564001802 Switch II region; other site 512564001803 G4 box; other site 512564001804 G5 box; other site 512564001805 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 512564001806 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 512564001807 nucleotide binding pocket [chemical binding]; other site 512564001808 K-X-D-G motif; other site 512564001809 catalytic site [active] 512564001810 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 512564001811 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 512564001812 Dimer interface [polypeptide binding]; other site 512564001813 BRCT sequence motif; other site 512564001814 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 512564001815 catalytic residues [active] 512564001816 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 512564001817 Uncharacterized conserved protein [Function unknown]; Region: COG1284 512564001818 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 512564001819 ribosome recycling factor; Reviewed; Region: frr; PRK00083 512564001820 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 512564001821 hinge region; other site 512564001822 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 512564001823 putative nucleotide binding site [chemical binding]; other site 512564001824 uridine monophosphate binding site [chemical binding]; other site 512564001825 homohexameric interface [polypeptide binding]; other site 512564001826 prolyl-tRNA synthetase; Provisional; Region: PRK08661 512564001827 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 512564001828 dimer interface [polypeptide binding]; other site 512564001829 motif 1; other site 512564001830 active site 512564001831 motif 2; other site 512564001832 motif 3; other site 512564001833 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 512564001834 anticodon binding site; other site 512564001835 zinc-binding site [ion binding]; other site 512564001836 Phosphopantetheine attachment site; Region: PP-binding; cl09936 512564001837 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 512564001838 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 512564001839 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 512564001840 trigger factor; Region: tig; TIGR00115 512564001841 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 512564001842 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 512564001843 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 512564001844 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13651 512564001845 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 512564001846 Walker A/P-loop; other site 512564001847 ATP binding site [chemical binding]; other site 512564001848 Q-loop/lid; other site 512564001849 ABC transporter signature motif; other site 512564001850 Walker B; other site 512564001851 D-loop; other site 512564001852 H-loop/switch region; other site 512564001853 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13632 512564001854 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 512564001855 Walker A/P-loop; other site 512564001856 ATP binding site [chemical binding]; other site 512564001857 Q-loop/lid; other site 512564001858 ABC transporter signature motif; other site 512564001859 Walker B; other site 512564001860 D-loop; other site 512564001861 H-loop/switch region; other site 512564001862 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 512564001863 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 512564001864 RNA/DNA hybrid binding site [nucleotide binding]; other site 512564001865 active site 512564001866 beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555 512564001867 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 512564001868 sugar binding site [chemical binding]; other site 512564001869 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 512564001870 NPCBM/NEW2 domain; Region: NPCBM; cl07060 512564001871 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 512564001872 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 512564001873 sugar binding site [chemical binding]; other site 512564001874 elongation factor G; Reviewed; Region: PRK12739 512564001875 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 512564001876 G1 box; other site 512564001877 putative GEF interaction site [polypeptide binding]; other site 512564001878 GTP/Mg2+ binding site [chemical binding]; other site 512564001879 Switch I region; other site 512564001880 G2 box; other site 512564001881 G3 box; other site 512564001882 Switch II region; other site 512564001883 G4 box; other site 512564001884 G5 box; other site 512564001885 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 512564001886 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 512564001887 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 512564001888 30S ribosomal protein S7; Validated; Region: PRK05302 512564001889 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 512564001890 S17 interaction site [polypeptide binding]; other site 512564001891 S8 interaction site; other site 512564001892 16S rRNA interaction site [nucleotide binding]; other site 512564001893 streptomycin interaction site [chemical binding]; other site 512564001894 23S rRNA interaction site [nucleotide binding]; other site 512564001895 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 512564001896 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 512564001897 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 512564001898 RNA binding surface [nucleotide binding]; other site 512564001899 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 512564001900 active site 512564001901 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 512564001902 active site 512564001903 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 512564001904 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512564001905 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 512564001906 Walker A motif; other site 512564001907 ATP binding site [chemical binding]; other site 512564001908 Walker B motif; other site 512564001909 arginine finger; other site 512564001910 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 512564001911 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 512564001912 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 512564001913 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 512564001914 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 512564001915 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 512564001916 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 512564001917 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 512564001918 HsdM N-terminal domain; Region: HsdM_N; pfam12161 512564001919 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 512564001920 S-adenosylmethionine binding site [chemical binding]; other site 512564001921 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 512564001922 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512564001923 dimer interface [polypeptide binding]; other site 512564001924 conserved gate region; other site 512564001925 putative PBP binding loops; other site 512564001926 ABC-ATPase subunit interface; other site 512564001927 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 512564001928 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512564001929 dimer interface [polypeptide binding]; other site 512564001930 conserved gate region; other site 512564001931 putative PBP binding loops; other site 512564001932 ABC-ATPase subunit interface; other site 512564001933 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 512564001934 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512564001935 Walker A/P-loop; other site 512564001936 ATP binding site [chemical binding]; other site 512564001937 Q-loop/lid; other site 512564001938 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 512564001939 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512564001940 ABC transporter signature motif; other site 512564001941 Walker B; other site 512564001942 D-loop; other site 512564001943 H-loop/switch region; other site 512564001944 Staphylococcal nuclease homologues; Region: SNc; smart00318 512564001945 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 512564001946 Catalytic site; other site 512564001947 Mycoplasma MG185/MG260 protein; Region: Lipoprotein_X; pfam03305 512564001948 Putative mycoplasma lipoprotein, C-terminal region; Region: Lipoprotein_10; pfam03202 512564001949 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 512564001950 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 512564001951 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 512564001952 Walker A/P-loop; other site 512564001953 ATP binding site [chemical binding]; other site 512564001954 Q-loop/lid; other site 512564001955 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 512564001956 ABC transporter; Region: ABC_tran_2; pfam12848 512564001957 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 512564001958 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 512564001959 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 512564001960 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 512564001961 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 512564001962 sugar binding site [chemical binding]; other site 512564001963 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 512564001964 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 512564001965 active site 512564001966 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 512564001967 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 512564001968 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 512564001969 active site 512564001970 Podoplanin; Region: Podoplanin; pfam05808 512564001971 HflC protein; Region: hflC; TIGR01932 512564001972 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 512564001973 beta-phosphoglucomutase; Region: bPGM; TIGR01990 512564001974 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512564001975 motif II; other site 512564001976 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 512564001977 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 512564001978 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 512564001979 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 512564001980 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 512564001981 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 512564001982 active site 512564001983 catalytic site [active] 512564001984 pullulanase, type I; Region: pulA_typeI; TIGR02104 512564001985 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 512564001986 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 512564001987 Ca binding site [ion binding]; other site 512564001988 active site 512564001989 catalytic site [active] 512564001990 Ferritin-like domain; Region: Ferritin; pfam00210 512564001991 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 512564001992 dimerization interface [polypeptide binding]; other site 512564001993 DPS ferroxidase diiron center [ion binding]; other site 512564001994 ion pore; other site 512564001995 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 512564001996 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 512564001997 Walker A/P-loop; other site 512564001998 ATP binding site [chemical binding]; other site 512564001999 Q-loop/lid; other site 512564002000 ABC transporter signature motif; other site 512564002001 Walker B; other site 512564002002 D-loop; other site 512564002003 H-loop/switch region; other site 512564002004 TOBE domain; Region: TOBE_2; pfam08402 512564002005 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 512564002006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512564002007 dimer interface [polypeptide binding]; other site 512564002008 conserved gate region; other site 512564002009 putative PBP binding loops; other site 512564002010 ABC-ATPase subunit interface; other site 512564002011 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 512564002012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 512564002013 dimer interface [polypeptide binding]; other site 512564002014 conserved gate region; other site 512564002015 putative PBP binding loops; other site 512564002016 ABC-ATPase subunit interface; other site 512564002017 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 512564002018 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316 512564002019 Ca binding site [ion binding]; other site 512564002020 active site 512564002021 catalytic site [active] 512564002022 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 512564002023 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 512564002024 DNA-binding site [nucleotide binding]; DNA binding site 512564002025 Predicted methyltransferases [General function prediction only]; Region: COG0313 512564002026 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 512564002027 putative SAM binding site [chemical binding]; other site 512564002028 putative homodimer interface [polypeptide binding]; other site 512564002029 DNA polymerase III subunit delta'; Validated; Region: PRK07132 512564002030 DNA polymerase III subunit delta'; Validated; Region: PRK08485 512564002031 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 512564002032 thymidylate kinase; Validated; Region: tmk; PRK00698 512564002033 TMP-binding site; other site 512564002034 ATP-binding site [chemical binding]; other site 512564002035 recombination protein RecR; Reviewed; Region: recR; PRK00076 512564002036 RecR protein; Region: RecR; pfam02132 512564002037 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 512564002038 active site 512564002039 metal binding site [ion binding]; metal-binding site 512564002040 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0718 512564002041 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07133 512564002042 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512564002043 Walker A motif; other site 512564002044 ATP binding site [chemical binding]; other site 512564002045 Walker B motif; other site 512564002046 arginine finger; other site 512564002047 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 512564002048 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; cl02331 512564002049 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 512564002050 signal recognition particle protein; Provisional; Region: PRK10867 512564002051 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 512564002052 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 512564002053 P loop; other site 512564002054 GTP binding site [chemical binding]; other site 512564002055 Signal peptide binding domain; Region: SRP_SPB; pfam02978 512564002056 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 512564002057 catalytic residues [active] 512564002058 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 512564002059 nucleotide binding site/active site [active] 512564002060 HIT family signature motif; other site 512564002061 catalytic residue [active] 512564002062 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 512564002063 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 512564002064 dimer interface [polypeptide binding]; other site 512564002065 putative radical transfer pathway; other site 512564002066 diiron center [ion binding]; other site 512564002067 tyrosyl radical; other site 512564002068 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 512564002069 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07187 512564002070 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 512564002071 Class I ribonucleotide reductase; Region: RNR_I; cd01679 512564002072 active site 512564002073 dimer interface [polypeptide binding]; other site 512564002074 catalytic residues [active] 512564002075 effector binding site; other site 512564002076 R2 peptide binding site; other site 512564002077 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 512564002078 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 512564002079 folate binding site [chemical binding]; other site 512564002080 NADP+ binding site [chemical binding]; other site 512564002081 thymidylate synthase; Reviewed; Region: thyA; PRK01827 512564002082 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 512564002083 dimerization interface [polypeptide binding]; other site 512564002084 active site 512564002085 DpnII restriction endonuclease; Region: DpnII; pfam04556 512564002086 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 512564002087 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 512564002088 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 512564002089 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02201 512564002090 Ribonuclease P; Region: Ribonuclease_P; pfam00825 512564002091 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 512564002092 seryl-tRNA synthetase; Provisional; Region: PRK05431 512564002093 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 512564002094 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 512564002095 dimer interface [polypeptide binding]; other site 512564002096 active site 512564002097 motif 1; other site 512564002098 motif 2; other site 512564002099 motif 3; other site 512564002100 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 512564002101 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 512564002102 LicD family; Region: LicD; pfam04991 512564002103 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 512564002104 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 512564002105 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 512564002106 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 512564002107 DNA polymerase III PolC; Validated; Region: polC; PRK00448 512564002108 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 512564002109 amphipathic channel; other site 512564002110 Asn-Pro-Ala signature motifs; other site 512564002111 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 512564002112 hydroxyglutarate oxidase; Provisional; Region: PRK11728 512564002113 glycerol kinase; Provisional; Region: glpK; PRK00047 512564002114 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 512564002115 N- and C-terminal domain interface [polypeptide binding]; other site 512564002116 active site 512564002117 MgATP binding site [chemical binding]; other site 512564002118 catalytic site [active] 512564002119 metal binding site [ion binding]; metal-binding site 512564002120 glycerol binding site [chemical binding]; other site 512564002121 homotetramer interface [polypeptide binding]; other site 512564002122 homodimer interface [polypeptide binding]; other site 512564002123 FBP binding site [chemical binding]; other site 512564002124 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 512564002125 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 512564002126 active site 512564002127 motif I; other site 512564002128 motif II; other site 512564002129 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 512564002130 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 512564002131 dimer interface [polypeptide binding]; other site 512564002132 putative anticodon binding site; other site 512564002133 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 512564002134 motif 1; other site 512564002135 active site 512564002136 motif 2; other site 512564002137 motif 3; other site 512564002138 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 512564002139 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 512564002140 Walker A/P-loop; other site 512564002141 ATP binding site [chemical binding]; other site 512564002142 Q-loop/lid; other site 512564002143 ABC transporter signature motif; other site 512564002144 Walker B; other site 512564002145 D-loop; other site 512564002146 H-loop/switch region; other site 512564002147 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 512564002148 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 512564002149 Walker B motif; other site 512564002150 arginine finger; other site 512564002151 Peptidase family M41; Region: Peptidase_M41; pfam01434 512564002152 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 512564002153 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 512564002154 Ligand Binding Site [chemical binding]; other site 512564002155 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 512564002156 putative active site [active] 512564002157 catalytic residue [active] 512564002158 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 512564002159 AAA domain; Region: AAA_30; pfam13604 512564002160 Family description; Region: UvrD_C_2; pfam13538