-- dump date 20140619_160133 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1159203000001 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1159203000002 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1159203000003 P-loop; other site 1159203000004 Magnesium ion binding site [ion binding]; other site 1159203000005 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1159203000006 Magnesium ion binding site [ion binding]; other site 1159203000007 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1159203000008 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1159203000009 Walker A motif; other site 1159203000010 ATP binding site [chemical binding]; other site 1159203000011 Walker B motif; other site 1159203000012 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1159203000013 DnaA box-binding interface [nucleotide binding]; other site 1159203000014 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1159203000015 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1159203000016 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1159203000017 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1159203000018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1159203000019 Walker A/P-loop; other site 1159203000020 ATP binding site [chemical binding]; other site 1159203000021 Q-loop/lid; other site 1159203000022 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1159203000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1159203000024 Walker B; other site 1159203000025 D-loop; other site 1159203000026 H-loop/switch region; other site 1159203000027 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1159203000028 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1159203000029 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1159203000030 Walker A/P-loop; other site 1159203000031 ATP binding site [chemical binding]; other site 1159203000032 Q-loop/lid; other site 1159203000033 ABC transporter signature motif; other site 1159203000034 Walker B; other site 1159203000035 D-loop; other site 1159203000036 H-loop/switch region; other site 1159203000037 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1159203000038 Ribonuclease P; Region: Ribonuclease_P; pfam00825 1159203000039 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02201 1159203000040 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1159203000041 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1159203000042 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1159203000043 S-adenosylmethionine binding site [chemical binding]; other site 1159203000044 hypothetical protein; Provisional; Region: PRK05905 1159203000045 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1159203000046 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 1159203000047 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 1159203000048 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1159203000049 active site 1159203000050 HIGH motif; other site 1159203000051 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1159203000052 KMSK motif region; other site 1159203000053 tRNA binding surface [nucleotide binding]; other site 1159203000054 DALR anticodon binding domain; Region: DALR_1; smart00836 1159203000055 anticodon binding site; other site 1159203000056 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1159203000057 putative catalytic site [active] 1159203000058 putative metal binding site [ion binding]; other site 1159203000059 putative phosphate binding site [ion binding]; other site 1159203000060 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1159203000061 amphipathic channel; other site 1159203000062 Asn-Pro-Ala signature motifs; other site 1159203000063 glycerol kinase; Provisional; Region: glpK; PRK00047 1159203000064 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1159203000065 N- and C-terminal domain interface [polypeptide binding]; other site 1159203000066 active site 1159203000067 MgATP binding site [chemical binding]; other site 1159203000068 catalytic site [active] 1159203000069 metal binding site [ion binding]; metal-binding site 1159203000070 glycerol binding site [chemical binding]; other site 1159203000071 homotetramer interface [polypeptide binding]; other site 1159203000072 homodimer interface [polypeptide binding]; other site 1159203000073 FBP binding site [chemical binding]; other site 1159203000074 protein IIAGlc interface [polypeptide binding]; other site 1159203000075 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1159203000076 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1159203000077 Putative peptidase (DUF31); Region: DUF31; pfam01732 1159203000078 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1159203000079 Ferritin-like domain; Region: Ferritin; pfam00210 1159203000080 dinuclear metal binding motif [ion binding]; other site 1159203000081 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1159203000082 Ligand Binding Site [chemical binding]; other site 1159203000083 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1159203000084 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1159203000085 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1159203000086 FtsX-like permease family; Region: FtsX; pfam02687 1159203000087 FtsX-like permease family; Region: FtsX; pfam02687 1159203000088 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1159203000089 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1159203000090 Walker A/P-loop; other site 1159203000091 ATP binding site [chemical binding]; other site 1159203000092 Q-loop/lid; other site 1159203000093 ABC transporter signature motif; other site 1159203000094 Walker B; other site 1159203000095 D-loop; other site 1159203000096 H-loop/switch region; other site 1159203000097 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1159203000098 homotrimer interaction site [polypeptide binding]; other site 1159203000099 zinc binding site [ion binding]; other site 1159203000100 CDP-binding sites; other site 1159203000101 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1159203000102 active site 1159203000103 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1159203000104 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1159203000105 Walker A motif; other site 1159203000106 ATP binding site [chemical binding]; other site 1159203000107 Walker B motif; other site 1159203000108 arginine finger; other site 1159203000109 Peptidase family M41; Region: Peptidase_M41; pfam01434 1159203000110 DAK2 domain; Region: Dak2; pfam02734 1159203000111 Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]; Region: COG5219 1159203000112 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1159203000113 dimerization domain swap beta strand [polypeptide binding]; other site 1159203000114 regulatory protein interface [polypeptide binding]; other site 1159203000115 active site 1159203000116 regulatory phosphorylation site [posttranslational modification]; other site 1159203000117 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1159203000118 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1159203000119 TPP-binding site [chemical binding]; other site 1159203000120 dimer interface [polypeptide binding]; other site 1159203000121 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1159203000122 PYR/PP interface [polypeptide binding]; other site 1159203000123 dimer interface [polypeptide binding]; other site 1159203000124 TPP binding site [chemical binding]; other site 1159203000125 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1159203000126 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12903 1159203000127 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1159203000128 Mycoplasma MG185/MG260 protein; Region: Lipoprotein_X; pfam03305 1159203000129 Putative mycoplasma lipoprotein, C-terminal region; Region: Lipoprotein_10; pfam03202 1159203000130 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 1159203000131 Catalytic site; other site 1159203000132 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1159203000133 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1159203000134 Walker A/P-loop; other site 1159203000135 ATP binding site [chemical binding]; other site 1159203000136 Q-loop/lid; other site 1159203000137 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1159203000138 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1159203000139 ABC transporter signature motif; other site 1159203000140 Walker B; other site 1159203000141 D-loop; other site 1159203000142 H-loop/switch region; other site 1159203000143 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1159203000144 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1159203000145 dimer interface [polypeptide binding]; other site 1159203000146 conserved gate region; other site 1159203000147 putative PBP binding loops; other site 1159203000148 ABC-ATPase subunit interface; other site 1159203000149 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1159203000150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1159203000151 dimer interface [polypeptide binding]; other site 1159203000152 conserved gate region; other site 1159203000153 putative PBP binding loops; other site 1159203000154 ABC-ATPase subunit interface; other site 1159203000155 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1159203000156 DHH family; Region: DHH; pfam01368 1159203000157 DHHA1 domain; Region: DHHA1; pfam02272 1159203000158 excinuclease ABC subunit B; Provisional; Region: PRK05298 1159203000159 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1159203000160 ATP binding site [chemical binding]; other site 1159203000161 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1159203000162 nucleotide binding region [chemical binding]; other site 1159203000163 ATP-binding site [chemical binding]; other site 1159203000164 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1159203000165 UvrB/uvrC motif; Region: UVR; pfam02151 1159203000166 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 1159203000167 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1159203000168 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1159203000169 dimer interface [polypeptide binding]; other site 1159203000170 conserved gate region; other site 1159203000171 putative PBP binding loops; other site 1159203000172 ABC-ATPase subunit interface; other site 1159203000173 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1159203000174 dimer interface [polypeptide binding]; other site 1159203000175 conserved gate region; other site 1159203000176 ABC-ATPase subunit interface; other site 1159203000177 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1159203000178 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1159203000179 Walker A/P-loop; other site 1159203000180 ATP binding site [chemical binding]; other site 1159203000181 Q-loop/lid; other site 1159203000182 ABC transporter signature motif; other site 1159203000183 Walker B; other site 1159203000184 D-loop; other site 1159203000185 H-loop/switch region; other site 1159203000186 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1159203000187 PhoU domain; Region: PhoU; pfam01895 1159203000188 PhoU domain; Region: PhoU; pfam01895 1159203000189 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07187 1159203000190 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1159203000191 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 1159203000192 Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867 1159203000193 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1159203000194 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1159203000195 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1159203000196 dimer interface [polypeptide binding]; other site 1159203000197 putative radical transfer pathway; other site 1159203000198 diiron center [ion binding]; other site 1159203000199 tyrosyl radical; other site 1159203000200 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1159203000201 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1159203000202 dimerization interface [polypeptide binding]; other site 1159203000203 active site 1159203000204 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1159203000205 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1159203000206 folate binding site [chemical binding]; other site 1159203000207 NADP+ binding site [chemical binding]; other site 1159203000208 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1159203000209 catalytic motif [active] 1159203000210 Zn binding site [ion binding]; other site 1159203000211 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1159203000212 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1159203000213 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1159203000214 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1159203000215 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1159203000216 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1159203000217 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1159203000218 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1159203000219 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1159203000220 putative translocon binding site; other site 1159203000221 protein-rRNA interface [nucleotide binding]; other site 1159203000222 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1159203000223 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1159203000224 G-X-X-G motif; other site 1159203000225 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1159203000226 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1159203000227 23S rRNA interface [nucleotide binding]; other site 1159203000228 5S rRNA interface [nucleotide binding]; other site 1159203000229 putative antibiotic binding site [chemical binding]; other site 1159203000230 L25 interface [polypeptide binding]; other site 1159203000231 L27 interface [polypeptide binding]; other site 1159203000232 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1159203000233 23S rRNA interface [nucleotide binding]; other site 1159203000234 putative translocon interaction site; other site 1159203000235 signal recognition particle (SRP54) interaction site; other site 1159203000236 L23 interface [polypeptide binding]; other site 1159203000237 trigger factor interaction site; other site 1159203000238 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1159203000239 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1159203000240 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1159203000241 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1159203000242 RNA binding site [nucleotide binding]; other site 1159203000243 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1159203000244 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1159203000245 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1159203000246 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1159203000247 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1159203000248 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1159203000249 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1159203000250 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1159203000251 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1159203000252 5S rRNA interface [nucleotide binding]; other site 1159203000253 L5 interface [polypeptide binding]; other site 1159203000254 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1159203000255 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1159203000256 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1159203000257 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1159203000258 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1159203000259 SecY translocase; Region: SecY; pfam00344 1159203000260 adenylate kinase; Region: adk; TIGR01351 1159203000261 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1159203000262 AMP-binding site [chemical binding]; other site 1159203000263 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1159203000264 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1159203000265 active site 1159203000266 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1159203000267 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1159203000268 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1159203000269 NAD binding site [chemical binding]; other site 1159203000270 dimer interface [polypeptide binding]; other site 1159203000271 substrate binding site [chemical binding]; other site 1159203000272 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1159203000273 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1159203000274 dimer interface [polypeptide binding]; other site 1159203000275 putative anticodon binding site; other site 1159203000276 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1159203000277 motif 1; other site 1159203000278 active site 1159203000279 motif 2; other site 1159203000280 motif 3; other site 1159203000281 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1159203000282 HSP70 interaction site [polypeptide binding]; other site 1159203000283 DnaJ domain; Region: DnaJ; pfam00226 1159203000284 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 1159203000285 heme oxygenase, HugZ family; Region: heme_ox_HugZ; TIGR04109 1159203000286 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1159203000287 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 1159203000288 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1159203000289 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1159203000290 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1159203000291 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1159203000292 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1159203000293 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1159203000294 16S/18S rRNA binding site [nucleotide binding]; other site 1159203000295 S13e-L30e interaction site [polypeptide binding]; other site 1159203000296 25S rRNA binding site [nucleotide binding]; other site 1159203000297 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1159203000298 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1159203000299 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1159203000300 catalytic residues [active] 1159203000301 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1159203000302 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1159203000303 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1159203000304 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1159203000305 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1159203000306 elongation factor Ts; Provisional; Region: tsf; PRK09377 1159203000307 UBA/TS-N domain; Region: UBA; pfam00627 1159203000308 putative protein-protein interaction site; other site 1159203000309 GFP-loop; other site 1159203000310 Elongation factor TS; Region: EF_TS; pfam00889 1159203000311 Elongation factor TS; Region: EF_TS; pfam00889 1159203000312 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1159203000313 putative nucleotide binding site [chemical binding]; other site 1159203000314 uridine monophosphate binding site [chemical binding]; other site 1159203000315 homohexameric interface [polypeptide binding]; other site 1159203000316 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1159203000317 Ribosome recycling factor; Region: RRF; pfam01765 1159203000318 hinge region; other site 1159203000319 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1159203000320 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1159203000321 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1159203000322 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1159203000323 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1159203000324 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1159203000325 Peptidase family M50; Region: Peptidase_M50; pfam02163 1159203000326 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 1159203000327 active site 1159203000328 putative substrate binding region [chemical binding]; other site 1159203000329 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1159203000330 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1159203000331 active site 1159203000332 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1159203000333 active site 1159203000334 catalytic site [active] 1159203000335 substrate binding site [chemical binding]; other site 1159203000336 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1159203000337 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1159203000338 Part of AAA domain; Region: AAA_19; pfam13245 1159203000339 AAA domain; Region: AAA_12; pfam13087 1159203000340 Peptidase S8 family domain, uncharacterized subfamily 2; Region: Peptidases_S8_2; cd07488 1159203000341 putative catalytic residues [active] 1159203000342 putative active site [active] 1159203000343 MULE transposase domain; Region: MULE; pfam10551 1159203000344 MULE transposase domain; Region: MULE; pfam10551 1159203000345 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1159203000346 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1159203000347 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1159203000348 Walker A/P-loop; other site 1159203000349 ATP binding site [chemical binding]; other site 1159203000350 Q-loop/lid; other site 1159203000351 ABC transporter signature motif; other site 1159203000352 Walker B; other site 1159203000353 D-loop; other site 1159203000354 H-loop/switch region; other site 1159203000355 aromatic cluster surface protein; Region: aro_clust_Mycop; TIGR04313 1159203000356 aromatic cluster surface protein; Region: aro_clust_Mycop; TIGR04313 1159203000357 MULE transposase domain; Region: MULE; pfam10551 1159203000358 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1159203000359 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1159203000360 active site 1159203000361 catalytic residues [active] 1159203000362 transcription termination factor NusA; Region: NusA; TIGR01953 1159203000363 NusA N-terminal domain; Region: NusA_N; pfam08529 1159203000364 NusA-like KH domain; Region: KH_5; pfam13184 1159203000365 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1159203000366 G-X-X-G motif; other site 1159203000367 Protein of unknown function (DUF448); Region: DUF448; pfam04296 1159203000368 putative RNA binding cleft [nucleotide binding]; other site 1159203000369 translation initiation factor IF-2; Region: IF-2; TIGR00487 1159203000370 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1159203000371 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1159203000372 G1 box; other site 1159203000373 putative GEF interaction site [polypeptide binding]; other site 1159203000374 GTP/Mg2+ binding site [chemical binding]; other site 1159203000375 Switch I region; other site 1159203000376 G2 box; other site 1159203000377 G3 box; other site 1159203000378 Switch II region; other site 1159203000379 G4 box; other site 1159203000380 G5 box; other site 1159203000381 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1159203000382 Translation-initiation factor 2; Region: IF-2; pfam11987 1159203000383 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1159203000384 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1159203000385 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1159203000386 MULE transposase domain; Region: MULE; pfam10551 1159203000387 potential frameshift: common BLAST hit: gi|385326404|ref|YP_005880841.1| putative transposase 1159203000388 MULE transposase domain; Region: MULE; pfam10551 1159203000389 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1159203000390 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 1159203000391 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1159203000392 RNA binding site [nucleotide binding]; other site 1159203000393 active site 1159203000394 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 1159203000395 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1159203000396 active site 1159203000397 Riboflavin kinase; Region: Flavokinase; pfam01687 1159203000398 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1159203000399 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1159203000400 Ligand Binding Site [chemical binding]; other site 1159203000401 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 1159203000402 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1159203000403 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1159203000404 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1159203000405 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1159203000406 motif 1; other site 1159203000407 active site 1159203000408 motif 2; other site 1159203000409 motif 3; other site 1159203000410 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1159203000411 DHHA1 domain; Region: DHHA1; pfam02272 1159203000412 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 1159203000413 Methyltransferase domain; Region: Methyltransf_18; pfam12847 1159203000414 S-adenosylmethionine binding site [chemical binding]; other site 1159203000415 Peptidase family U32; Region: Peptidase_U32; pfam01136 1159203000416 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1159203000417 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1159203000418 Peptidase family U32; Region: Peptidase_U32; pfam01136 1159203000419 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1159203000420 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1159203000421 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1159203000422 putative active site [active] 1159203000423 substrate binding site [chemical binding]; other site 1159203000424 putative cosubstrate binding site; other site 1159203000425 catalytic site [active] 1159203000426 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1159203000427 substrate binding site [chemical binding]; other site 1159203000428 Domain of unknown function(DUF2779); Region: DUF2779; pfam11074 1159203000429 Domain of unknown function (DUF386); Region: DUF386; cl01047 1159203000430 hypothetical protein; Provisional; Region: PRK12378 1159203000431 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1159203000432 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1159203000433 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264 1159203000434 active site turn [active] 1159203000435 phosphorylation site [posttranslational modification] 1159203000436 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1159203000437 HPr interaction site; other site 1159203000438 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1159203000439 active site 1159203000440 phosphorylation site [posttranslational modification] 1159203000441 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 1159203000442 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1159203000443 tetrameric interface [polypeptide binding]; other site 1159203000444 activator binding site; other site 1159203000445 NADP binding site [chemical binding]; other site 1159203000446 substrate binding site [chemical binding]; other site 1159203000447 catalytic residues [active] 1159203000448 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1159203000449 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1159203000450 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1159203000451 RF-1 domain; Region: RF-1; pfam00472 1159203000452 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 1159203000453 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1159203000454 S-adenosylmethionine binding site [chemical binding]; other site 1159203000455 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1159203000456 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1159203000457 Recombination protein U; Region: RecU; pfam03838 1159203000458 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1159203000459 IHF - DNA interface [nucleotide binding]; other site 1159203000460 IHF dimer interface [polypeptide binding]; other site 1159203000461 Domain of unknown function (DUF1951); Region: DUF1951; pfam09188 1159203000462 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1159203000463 23S rRNA interface [nucleotide binding]; other site 1159203000464 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1159203000465 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1159203000466 core dimer interface [polypeptide binding]; other site 1159203000467 peripheral dimer interface [polypeptide binding]; other site 1159203000468 L10 interface [polypeptide binding]; other site 1159203000469 L11 interface [polypeptide binding]; other site 1159203000470 putative EF-Tu interaction site [polypeptide binding]; other site 1159203000471 putative EF-G interaction site [polypeptide binding]; other site 1159203000472 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 1159203000473 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 1159203000474 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1159203000475 HSP70 interaction site [polypeptide binding]; other site 1159203000476 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1159203000477 Zn binding sites [ion binding]; other site 1159203000478 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 1159203000479 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1159203000480 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1159203000481 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1159203000482 tRNA binding surface [nucleotide binding]; other site 1159203000483 anticodon binding site; other site 1159203000484 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1159203000485 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1159203000486 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1159203000487 HSP70 interaction site [polypeptide binding]; other site 1159203000488 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1159203000489 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1159203000490 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1159203000491 tRNA binding surface [nucleotide binding]; other site 1159203000492 anticodon binding site; other site 1159203000493 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1159203000494 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1159203000495 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1159203000496 HSP70 interaction site [polypeptide binding]; other site 1159203000497 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1159203000498 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1159203000499 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 1159203000500 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1159203000501 active site 1159203000502 HIGH motif; other site 1159203000503 KMSKS motif; other site 1159203000504 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1159203000505 tRNA binding surface [nucleotide binding]; other site 1159203000506 anticodon binding site; other site 1159203000507 ribosome-associated GTPase EngA; Region: GTPase_EngA; TIGR03594 1159203000508 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1159203000509 G1 box; other site 1159203000510 GTP/Mg2+ binding site [chemical binding]; other site 1159203000511 Switch I region; other site 1159203000512 G2 box; other site 1159203000513 Switch II region; other site 1159203000514 G3 box; other site 1159203000515 G4 box; other site 1159203000516 G5 box; other site 1159203000517 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1159203000518 G1 box; other site 1159203000519 GTP/Mg2+ binding site [chemical binding]; other site 1159203000520 Switch I region; other site 1159203000521 G2 box; other site 1159203000522 G3 box; other site 1159203000523 Switch II region; other site 1159203000524 G4 box; other site 1159203000525 G5 box; other site 1159203000526 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283 1159203000527 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1159203000528 CMP-binding site; other site 1159203000529 The sites determining sugar specificity; other site 1159203000530 DJ-1 family protein; Region: not_thiJ; TIGR01383 1159203000531 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1159203000532 conserved cys residue [active] 1159203000533 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1159203000534 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1159203000535 active site 1159203000536 catalytic residues [active] 1159203000537 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1159203000538 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1159203000539 coproporphyrinogen III oxidase; Provisional; Region: PRK05904 1159203000540 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1159203000541 FeS/SAM binding site; other site 1159203000542 HemN C-terminal domain; Region: HemN_C; pfam06969 1159203000543 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1159203000544 AAA domain; Region: AAA_23; pfam13476 1159203000545 Walker A/P-loop; other site 1159203000546 ATP binding site [chemical binding]; other site 1159203000547 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1159203000548 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1159203000549 ABC transporter signature motif; other site 1159203000550 Walker B; other site 1159203000551 D-loop; other site 1159203000552 H-loop/switch region; other site 1159203000553 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1159203000554 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1159203000555 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1159203000556 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 1159203000557 trigger factor; Provisional; Region: tig; PRK01490 1159203000558 Protein of unknown function (DUF3217); Region: DUF3217; pfam11506 1159203000559 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1159203000560 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1159203000561 active site 1159203000562 dimer interface [polypeptide binding]; other site 1159203000563 motif 1; other site 1159203000564 motif 2; other site 1159203000565 motif 3; other site 1159203000566 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1159203000567 anticodon binding site; other site 1159203000568 pathogenicity island 1 effector protein SipB; Provisional; Region: PRK15374 1159203000569 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 1159203000570 Phosphotransferase enzyme family; Region: APH; pfam01636 1159203000571 active site 1159203000572 ATP binding site [chemical binding]; other site 1159203000573 substrate binding site [chemical binding]; other site 1159203000574 dimer interface [polypeptide binding]; other site 1159203000575 Cytadhesin P30/P32; Region: Cytadhesin_P30; pfam07271 1159203000576 adhesin P1; Region: termin_org_P1; TIGR03839 1159203000577 adhesin P1; Region: termin_org_P1; TIGR03839 1159203000578 Trypsin-sensitive surface-exposed protein; Region: CytadhesinP1; pfam12378 1159203000579 Cytadhesin P30/P32; Region: Cytadhesin_P30; pfam07271 1159203000580 histidyl-tRNA synthetase; Region: hisS; TIGR00442 1159203000581 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1159203000582 dimer interface [polypeptide binding]; other site 1159203000583 motif 1; other site 1159203000584 active site 1159203000585 motif 2; other site 1159203000586 motif 3; other site 1159203000587 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 1159203000588 anticodon binding site; other site 1159203000589 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1159203000590 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1159203000591 Dimer interface [polypeptide binding]; other site 1159203000592 anticodon binding site; other site 1159203000593 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1159203000594 homodimer interface [polypeptide binding]; other site 1159203000595 motif 1; other site 1159203000596 active site 1159203000597 motif 2; other site 1159203000598 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1159203000599 active site 1159203000600 motif 3; other site 1159203000601 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 1159203000602 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1159203000603 Zn2+ binding site [ion binding]; other site 1159203000604 Mg2+ binding site [ion binding]; other site 1159203000605 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1159203000606 synthetase active site [active] 1159203000607 NTP binding site [chemical binding]; other site 1159203000608 metal binding site [ion binding]; metal-binding site 1159203000609 CTP synthetase; Validated; Region: pyrG; PRK05380 1159203000610 CTP synthase N-terminus; Region: CTP_synth_N; pfam06418 1159203000611 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1159203000612 active site 1159203000613 putative oxyanion hole; other site 1159203000614 catalytic triad [active] 1159203000615 6-carboxyhexanoate--CoA ligase; Region: BioW; cl00625 1159203000616 Protein export membrane protein; Region: SecD_SecF; cl14618 1159203000617 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1159203000618 active site 1159203000619 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1159203000620 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1159203000621 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1159203000622 Amino acid permease; Region: AA_permease_2; pfam13520 1159203000623 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1159203000624 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1159203000625 dimerization interface [polypeptide binding]; other site 1159203000626 DPS ferroxidase diiron center [ion binding]; other site 1159203000627 ion pore; other site 1159203000628 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 1159203000629 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 1159203000630 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 1159203000631 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 1159203000632 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 1159203000633 GA module; Region: GA; pfam01468 1159203000634 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 1159203000635 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 1159203000636 potential frameshift: common BLAST hit: gi|385326404|ref|YP_005880841.1| putative transposase 1159203000637 potential frameshift: common BLAST hit: gi|385326131|ref|YP_005880568.1| trasposase 1159203000638 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1159203000639 MULE transposase domain; Region: MULE; pfam10551 1159203000640 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1159203000641 trimer interface [polypeptide binding]; other site 1159203000642 active site 1159203000643 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1159203000644 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1159203000645 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1159203000646 active site 1159203000647 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1159203000648 lipoprotein signal peptidase; Provisional; Region: PRK14787 1159203000649 DJ-1 family protein; Region: not_thiJ; TIGR01383 1159203000650 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1159203000651 conserved cys residue [active] 1159203000652 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1159203000653 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1159203000654 nucleophilic elbow; other site 1159203000655 catalytic triad; other site 1159203000656 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1159203000657 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1159203000658 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1159203000659 RPB10 interaction site [polypeptide binding]; other site 1159203000660 RPB11 interaction site [polypeptide binding]; other site 1159203000661 RPB3 interaction site [polypeptide binding]; other site 1159203000662 RPB12 interaction site [polypeptide binding]; other site 1159203000663 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1159203000664 RPB1 interaction site [polypeptide binding]; other site 1159203000665 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1159203000666 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1159203000667 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1159203000668 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1159203000669 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1159203000670 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1159203000671 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1159203000672 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1159203000673 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1159203000674 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1159203000675 G-loop; other site 1159203000676 DNA binding site [nucleotide binding] 1159203000677 Yip1 domain; Region: Yip1; pfam04893 1159203000678 High affinity transport system protein p37; Region: Mycoplasma_p37; pfam06646 1159203000679 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1159203000680 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1159203000681 Walker A/P-loop; other site 1159203000682 ATP binding site [chemical binding]; other site 1159203000683 Q-loop/lid; other site 1159203000684 ABC transporter signature motif; other site 1159203000685 Walker B; other site 1159203000686 D-loop; other site 1159203000687 H-loop/switch region; other site 1159203000688 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 1159203000689 prolyl-tRNA synthetase; Provisional; Region: PRK08661 1159203000690 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 1159203000691 dimer interface [polypeptide binding]; other site 1159203000692 motif 1; other site 1159203000693 active site 1159203000694 motif 2; other site 1159203000695 motif 3; other site 1159203000696 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 1159203000697 anticodon binding site; other site 1159203000698 acyl carrier protein; Validated; Region: PRK05828 1159203000699 elongation factor Tu; Reviewed; Region: PRK00049 1159203000700 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1159203000701 G1 box; other site 1159203000702 GEF interaction site [polypeptide binding]; other site 1159203000703 GTP/Mg2+ binding site [chemical binding]; other site 1159203000704 Switch I region; other site 1159203000705 G2 box; other site 1159203000706 G3 box; other site 1159203000707 Switch II region; other site 1159203000708 G4 box; other site 1159203000709 G5 box; other site 1159203000710 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1159203000711 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1159203000712 Antibiotic Binding Site [chemical binding]; other site 1159203000713 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 1159203000714 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1159203000715 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1159203000716 putative tRNA-binding site [nucleotide binding]; other site 1159203000717 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1159203000718 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 1159203000719 DNA polymerase III DnaE; Validated; Region: dnaE; PRK05898 1159203000720 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 1159203000721 active site 1159203000722 PHP Thumb interface [polypeptide binding]; other site 1159203000723 5'-3' exonuclease; Provisional; Region: PRK14976 1159203000724 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1159203000725 active site 1159203000726 metal binding site 1 [ion binding]; metal-binding site 1159203000727 putative 5' ssDNA interaction site; other site 1159203000728 metal binding site 3; metal-binding site 1159203000729 metal binding site 2 [ion binding]; metal-binding site 1159203000730 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1159203000731 putative DNA binding site [nucleotide binding]; other site 1159203000732 putative metal binding site [ion binding]; other site 1159203000733 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1159203000734 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1159203000735 DNA binding site [nucleotide binding] 1159203000736 catalytic residue [active] 1159203000737 H2TH interface [polypeptide binding]; other site 1159203000738 putative catalytic residues [active] 1159203000739 turnover-facilitating residue; other site 1159203000740 intercalation triad [nucleotide binding]; other site 1159203000741 8OG recognition residue [nucleotide binding]; other site 1159203000742 putative reading head residues; other site 1159203000743 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1159203000744 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1159203000745 dephospho-CoA kinase; Region: TIGR00152 1159203000746 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1159203000747 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1159203000748 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1159203000749 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1159203000750 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1159203000751 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1159203000752 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1159203000753 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1159203000754 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1159203000755 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 1159203000756 putative dimer interface [polypeptide binding]; other site 1159203000757 putative anticodon binding site; other site 1159203000758 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1159203000759 homodimer interface [polypeptide binding]; other site 1159203000760 motif 1; other site 1159203000761 motif 2; other site 1159203000762 active site 1159203000763 motif 3; other site 1159203000764 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1159203000765 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1159203000766 substrate binding site; other site 1159203000767 dimer interface; other site 1159203000768 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1159203000769 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1159203000770 Walker A/P-loop; other site 1159203000771 ATP binding site [chemical binding]; other site 1159203000772 Q-loop/lid; other site 1159203000773 ABC transporter signature motif; other site 1159203000774 Walker B; other site 1159203000775 D-loop; other site 1159203000776 H-loop/switch region; other site 1159203000777 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 1159203000778 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1159203000779 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1159203000780 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1159203000781 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1159203000782 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1159203000783 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 1159203000784 active site 1159203000785 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1159203000786 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1159203000787 active site 1159203000788 motif I; other site 1159203000789 motif II; other site 1159203000790 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 1159203000791 inorganic pyrophosphatase; Provisional; Region: PRK02230 1159203000792 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1159203000793 dimer interface [polypeptide binding]; other site 1159203000794 substrate binding site [chemical binding]; other site 1159203000795 metal binding sites [ion binding]; metal-binding site 1159203000796 Protein of unknown function DUF45; Region: DUF45; pfam01863 1159203000797 FeS assembly ATPase SufC; Region: sufC; TIGR01978 1159203000798 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1159203000799 Walker A/P-loop; other site 1159203000800 ATP binding site [chemical binding]; other site 1159203000801 Q-loop/lid; other site 1159203000802 ABC transporter signature motif; other site 1159203000803 Walker B; other site 1159203000804 D-loop; other site 1159203000805 H-loop/switch region; other site 1159203000806 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 1159203000807 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1159203000808 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1159203000809 Aminotransferase class-V; Region: Aminotran_5; pfam00266 1159203000810 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1159203000811 catalytic residue [active] 1159203000812 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1159203000813 trimerization site [polypeptide binding]; other site 1159203000814 active site 1159203000815 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1159203000816 FeS assembly protein SufB; Region: sufB; TIGR01980 1159203000817 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1159203000818 HSP70 interaction site [polypeptide binding]; other site 1159203000819 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1159203000820 HSP70 interaction site [polypeptide binding]; other site 1159203000821 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00097 1159203000822 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 1159203000823 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1159203000824 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1159203000825 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1159203000826 HSP70 interaction site [polypeptide binding]; other site 1159203000827 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1159203000828 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 1159203000829 Walker A/P-loop; other site 1159203000830 ATP binding site [chemical binding]; other site 1159203000831 Q-loop/lid; other site 1159203000832 ABC transporter signature motif; other site 1159203000833 Walker B; other site 1159203000834 D-loop; other site 1159203000835 H-loop/switch region; other site 1159203000836 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1159203000837 OsmC-like protein; Region: OsmC; cl00767 1159203000838 signal recognition particle protein; Provisional; Region: PRK10867 1159203000839 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1159203000840 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1159203000841 P loop; other site 1159203000842 GTP binding site [chemical binding]; other site 1159203000843 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1159203000844 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1159203000845 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1159203000846 active site 1159203000847 HIGH motif; other site 1159203000848 dimer interface [polypeptide binding]; other site 1159203000849 KMSKS motif; other site 1159203000850 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 1159203000851 RNA binding surface [nucleotide binding]; other site 1159203000852 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1159203000853 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1159203000854 dimer interface [polypeptide binding]; other site 1159203000855 active site 1159203000856 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1159203000857 folate binding site [chemical binding]; other site 1159203000858 Transposase [DNA replication, recombination, and repair]; Region: COG5421 1159203000859 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 1159203000860 active site 1159203000861 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1159203000862 23S rRNA interface [nucleotide binding]; other site 1159203000863 L3 interface [polypeptide binding]; other site 1159203000864 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1159203000865 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1159203000866 GcpE protein; Region: GcpE; pfam04551 1159203000867 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1159203000868 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1159203000869 active site 1159203000870 Putative peptidase (DUF31); Region: DUF31; pfam01732 1159203000871 Peptidase S7, Flavivirus NS3 serine protease; Region: Peptidase_S7; pfam00949 1159203000872 ATP synthase A chain; Region: ATP-synt_A; cl00413 1159203000873 ATP synthase subunit C; Region: ATP-synt_C; cl00466 1159203000874 F0F1 ATP synthase subunit B; Validated; Region: PRK06231 1159203000875 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1159203000876 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1159203000877 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1159203000878 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1159203000879 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1159203000880 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1159203000881 beta subunit interaction interface [polypeptide binding]; other site 1159203000882 Walker A motif; other site 1159203000883 ATP binding site [chemical binding]; other site 1159203000884 Walker B motif; other site 1159203000885 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1159203000886 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1159203000887 core domain interface [polypeptide binding]; other site 1159203000888 delta subunit interface [polypeptide binding]; other site 1159203000889 epsilon subunit interface [polypeptide binding]; other site 1159203000890 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1159203000891 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1159203000892 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1159203000893 alpha subunit interaction interface [polypeptide binding]; other site 1159203000894 Walker A motif; other site 1159203000895 ATP binding site [chemical binding]; other site 1159203000896 Walker B motif; other site 1159203000897 inhibitor binding site; inhibition site 1159203000898 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1159203000899 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00539 1159203000900 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1159203000901 gamma subunit interface [polypeptide binding]; other site 1159203000902 epsilon subunit interface [polypeptide binding]; other site 1159203000903 LBP interface [polypeptide binding]; other site 1159203000904 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 1159203000905 EDD domain protein, DegV family; Region: DegV; TIGR00762 1159203000906 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1159203000907 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1159203000908 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1159203000909 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1159203000910 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 1159203000911 Phosphoglycerate kinase; Region: PGK; pfam00162 1159203000912 substrate binding site [chemical binding]; other site 1159203000913 hinge regions; other site 1159203000914 ADP binding site [chemical binding]; other site 1159203000915 catalytic site [active] 1159203000916 Amino acid permease; Region: AA_permease_2; pfam13520 1159203000917 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1159203000918 S-adenosylmethionine binding site [chemical binding]; other site 1159203000919 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1159203000920 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1159203000921 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1159203000922 active site 1159203000923 HIGH motif; other site 1159203000924 nucleotide binding site [chemical binding]; other site 1159203000925 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1159203000926 active site 1159203000927 KMSKS motif; other site 1159203000928 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1159203000929 tRNA binding surface [nucleotide binding]; other site 1159203000930 anticodon binding site; other site 1159203000931 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1159203000932 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1159203000933 Protein of unknown function (DUF1664); Region: DUF1664; pfam07889 1159203000934 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 1159203000935 V-type ATP synthase subunit I; Validated; Region: PRK05771 1159203000936 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1159203000937 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1159203000938 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1159203000939 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1159203000940 Amidinotransferase; Region: Amidinotransf; cl12043 1159203000941 potential frameshift: common BLAST hit: gi|385326404|ref|YP_005880841.1| putative transposase 1159203000942 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1159203000943 MULE transposase domain; Region: MULE; pfam10551 1159203000944 Amidinotransferase; Region: Amidinotransf; cl12043 1159203000945 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1159203000946 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1159203000947 phosphodiesterase; Provisional; Region: PRK12704 1159203000948 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1159203000949 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1159203000950 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1159203000951 nucleophilic elbow; other site 1159203000952 catalytic triad; other site 1159203000953 Serine hydrolase (FSH1); Region: FSH1; pfam03959 1159203000954 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1159203000955 HSP70 interaction site [polypeptide binding]; other site 1159203000956 EAGR box; Region: EAGR_box; TIGR03834 1159203000957 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 1159203000958 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1159203000959 dimer interface [polypeptide binding]; other site 1159203000960 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1159203000961 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1159203000962 dimer interface [polypeptide binding]; other site 1159203000963 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1159203000964 potential frameshift: common BLAST hit: gi|385326336|ref|YP_005880773.1| variably expressed lipoprotein and hemagglutinin (VlhA) family 1159203000965 Cobalamin biosynthesis protein CobN and related Mg-chelatases [Coenzyme metabolism]; Region: CobN; COG1429 1159203000966 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 1159203000967 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 1159203000968 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 1159203000969 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 1159203000970 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 1159203000971 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 1159203000972 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 1159203000973 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 1159203000974 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 1159203000975 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 1159203000976 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 1159203000977 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 1159203000978 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 1159203000979 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 1159203000980 potential frameshift: common BLAST hit: gi|385325456|ref|YP_005879894.1| putative beta-phosphoglucomutase (beta-PGM) 1159203000981 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 1159203000982 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1159203000983 potential frameshift: common BLAST hit: gi|385325457|ref|YP_005879895.1| putative maltose phosphorylase domain protein 1159203000984 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1159203000985 potential frameshift: common BLAST hit: gi|385326329|ref|YP_005880766.1| putative maltose phosphorylase domain protein 1159203000986 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1159203000987 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1159203000988 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1159203000989 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1159203000990 TPP-binding site; other site 1159203000991 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1159203000992 PYR/PP interface [polypeptide binding]; other site 1159203000993 dimer interface [polypeptide binding]; other site 1159203000994 TPP binding site [chemical binding]; other site 1159203000995 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1159203000996 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1159203000997 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1159203000998 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1159203000999 GIY-YIG motif/motif A; other site 1159203001000 active site 1159203001001 catalytic site [active] 1159203001002 putative DNA binding site [nucleotide binding]; other site 1159203001003 metal binding site [ion binding]; metal-binding site 1159203001004 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1159203001005 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1159203001006 translation initiation factor IF-3; Region: infC; TIGR00168 1159203001007 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1159203001008 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1159203001009 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1159203001010 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1159203001011 23S rRNA binding site [nucleotide binding]; other site 1159203001012 L21 binding site [polypeptide binding]; other site 1159203001013 L13 binding site [polypeptide binding]; other site 1159203001014 dUTPase; Region: dUTPase_2; pfam08761 1159203001015 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 1159203001016 active site 1159203001017 homodimer interface [polypeptide binding]; other site 1159203001018 metal binding site [ion binding]; metal-binding site 1159203001019 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1159203001020 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1159203001021 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1159203001022 dimer interface [polypeptide binding]; other site 1159203001023 motif 1; other site 1159203001024 active site 1159203001025 motif 2; other site 1159203001026 motif 3; other site 1159203001027 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1159203001028 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1159203001029 putative tRNA-binding site [nucleotide binding]; other site 1159203001030 B3/4 domain; Region: B3_4; pfam03483 1159203001031 tRNA synthetase B5 domain; Region: B5; smart00874 1159203001032 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1159203001033 dimer interface [polypeptide binding]; other site 1159203001034 motif 1; other site 1159203001035 motif 3; other site 1159203001036 motif 2; other site 1159203001037 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 1159203001038 active site 1159203001039 P-loop; other site 1159203001040 phosphorylation site [posttranslational modification] 1159203001041 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1159203001042 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1159203001043 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1159203001044 Walker A/P-loop; other site 1159203001045 ATP binding site [chemical binding]; other site 1159203001046 Q-loop/lid; other site 1159203001047 ABC transporter signature motif; other site 1159203001048 Walker B; other site 1159203001049 D-loop; other site 1159203001050 H-loop/switch region; other site 1159203001051 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1159203001052 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1159203001053 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1159203001054 Walker A/P-loop; other site 1159203001055 ATP binding site [chemical binding]; other site 1159203001056 Q-loop/lid; other site 1159203001057 ABC transporter signature motif; other site 1159203001058 Walker B; other site 1159203001059 D-loop; other site 1159203001060 H-loop/switch region; other site 1159203001061 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1159203001062 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1159203001063 Protein of unknown function (DUF464); Region: DUF464; pfam04327 1159203001064 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1159203001065 endonuclease IV; Provisional; Region: PRK01060 1159203001066 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1159203001067 AP (apurinic/apyrimidinic) site pocket; other site 1159203001068 DNA interaction; other site 1159203001069 Metal-binding active site; metal-binding site 1159203001070 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 1159203001071 metal binding site 2 [ion binding]; metal-binding site 1159203001072 putative DNA binding helix; other site 1159203001073 metal binding site 1 [ion binding]; metal-binding site 1159203001074 Protein of unknown function (DUF3196); Region: DUF3196; pfam11428 1159203001075 trigger factor; Region: tig; TIGR00115 1159203001076 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1159203001077 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1159203001078 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1159203001079 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1159203001080 Walker A motif; other site 1159203001081 ATP binding site [chemical binding]; other site 1159203001082 Walker B motif; other site 1159203001083 arginine finger; other site 1159203001084 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1159203001085 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 1159203001086 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1159203001087 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1159203001088 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1159203001089 Walker A/P-loop; other site 1159203001090 ATP binding site [chemical binding]; other site 1159203001091 Q-loop/lid; other site 1159203001092 ABC transporter signature motif; other site 1159203001093 Walker B; other site 1159203001094 D-loop; other site 1159203001095 H-loop/switch region; other site 1159203001096 potential frameshift: common BLAST hit: gi|385326291|ref|YP_005880728.1| MaoC-like dehydratase 1159203001097 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1159203001098 active site 2 [active] 1159203001099 active site 1 [active] 1159203001100 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1159203001101 active site 2 [active] 1159203001102 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1159203001103 MULE transposase domain; Region: MULE; pfam10551 1159203001104 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 1159203001105 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1159203001106 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1159203001107 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1159203001108 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1159203001109 putative active site [active] 1159203001110 metal binding site [ion binding]; metal-binding site 1159203001111 homodimer binding site [polypeptide binding]; other site 1159203001112 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1159203001113 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1159203001114 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1159203001115 Part of AAA domain; Region: AAA_19; pfam13245 1159203001116 Family description; Region: UvrD_C_2; pfam13538 1159203001117 RDD family; Region: RDD; pfam06271 1159203001118 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1159203001119 active site 1159203001120 NifU-like domain; Region: NifU; cl00484 1159203001121 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1159203001122 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1159203001123 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1159203001124 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1159203001125 Family of unknown function (DUF633); Region: DUF633; pfam04816 1159203001126 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 1159203001127 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1159203001128 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1159203001129 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1159203001130 DNA binding residues [nucleotide binding] 1159203001131 DNA primase (bacterial type) [DNA replication, recombination, and repair]; Region: DnaG; COG0358 1159203001132 CHC2 zinc finger; Region: zf-CHC2; cl17510 1159203001133 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1159203001134 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1159203001135 active site 1159203001136 metal binding site [ion binding]; metal-binding site 1159203001137 interdomain interaction site; other site 1159203001138 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1159203001139 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1159203001140 motif 1; other site 1159203001141 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1159203001142 active site 1159203001143 motif 2; other site 1159203001144 motif 3; other site 1159203001145 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 1159203001146 anticodon binding site; other site 1159203001147 Recombination protein O N terminal; Region: RecO_N; pfam11967 1159203001148 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 1159203001149 GTPase Era; Reviewed; Region: era; PRK00089 1159203001150 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1159203001151 G1 box; other site 1159203001152 GTP/Mg2+ binding site [chemical binding]; other site 1159203001153 Switch I region; other site 1159203001154 G2 box; other site 1159203001155 Switch II region; other site 1159203001156 G3 box; other site 1159203001157 G4 box; other site 1159203001158 G5 box; other site 1159203001159 KH domain; Region: KH_2; pfam07650 1159203001160 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 1159203001161 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 1159203001162 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39E; cd02424 1159203001163 putative active site [active] 1159203001164 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1159203001165 Walker A/P-loop; other site 1159203001166 ATP binding site [chemical binding]; other site 1159203001167 Q-loop/lid; other site 1159203001168 ABC transporter signature motif; other site 1159203001169 Walker B; other site 1159203001170 D-loop; other site 1159203001171 H-loop/switch region; other site 1159203001172 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 1159203001173 MULE transposase domain; Region: MULE; pfam10551 1159203001174 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1159203001175 nucleotide binding site [chemical binding]; other site 1159203001176 SulA interaction site; other site 1159203001177 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1159203001178 MraW methylase family; Region: Methyltransf_5; cl17771 1159203001179 cell division protein MraZ; Reviewed; Region: PRK00326 1159203001180 MraZ protein; Region: MraZ; pfam02381 1159203001181 MraZ protein; Region: MraZ; pfam02381 1159203001182 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 1159203001183 segregation and condensation protein A/unknown domain fusion protein; Provisional; Region: scpA; PRK00478 1159203001184 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1159203001185 folate binding site [chemical binding]; other site 1159203001186 NADP+ binding site [chemical binding]; other site 1159203001187 ScpA/B protein; Region: ScpA_ScpB; cl00598 1159203001188 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1159203001189 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1159203001190 putative acyl-acceptor binding pocket; other site 1159203001191 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1159203001192 cell division protein GpsB; Provisional; Region: PRK14127 1159203001193 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 1159203001194 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1159203001195 RNA/DNA hybrid binding site [nucleotide binding]; other site 1159203001196 active site 1159203001197 hypothetical protein; Provisional; Region: PRK06148 1159203001198 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1159203001199 AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271 1159203001200 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 1159203001201 putative nicotinate-nucleotide adenylyltransferase; Validated; Region: nadD; PRK07152 1159203001202 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1159203001203 active site 1159203001204 (T/H)XGH motif; other site 1159203001205 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1159203001206 Zn2+ binding site [ion binding]; other site 1159203001207 Mg2+ binding site [ion binding]; other site 1159203001208 ribosome biogenesis GTPase YqeH; Region: GTPase_YqeH; TIGR03597 1159203001209 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 1159203001210 GTP/Mg2+ binding site [chemical binding]; other site 1159203001211 G4 box; other site 1159203001212 G5 box; other site 1159203001213 G1 box; other site 1159203001214 Switch I region; other site 1159203001215 G2 box; other site 1159203001216 G3 box; other site 1159203001217 Switch II region; other site 1159203001218 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1159203001219 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1159203001220 CAP-like domain; other site 1159203001221 active site 1159203001222 primary dimer interface [polypeptide binding]; other site 1159203001223 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1159203001224 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1159203001225 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1159203001226 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1159203001227 ATP binding site [chemical binding]; other site 1159203001228 Mg2+ binding site [ion binding]; other site 1159203001229 G-X-G motif; other site 1159203001230 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1159203001231 anchoring element; other site 1159203001232 dimer interface [polypeptide binding]; other site 1159203001233 ATP binding site [chemical binding]; other site 1159203001234 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1159203001235 active site 1159203001236 putative metal-binding site [ion binding]; other site 1159203001237 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1159203001238 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1159203001239 IHF - DNA interface [nucleotide binding]; other site 1159203001240 IHF dimer interface [polypeptide binding]; other site 1159203001241 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 1159203001242 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 1159203001243 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 1159203001244 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 1159203001245 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 1159203001246 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 1159203001247 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 1159203001248 GA module; Region: GA; pfam01468 1159203001249 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 1159203001250 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 1159203001251 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 1159203001252 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 1159203001253 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1159203001254 TrkA-N domain; Region: TrkA_N; pfam02254 1159203001255 TrkA-C domain; Region: TrkA_C; pfam02080 1159203001256 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1159203001257 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1159203001258 HIGH motif; other site 1159203001259 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1159203001260 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1159203001261 active site 1159203001262 KMSKS motif; other site 1159203001263 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1159203001264 tRNA binding surface [nucleotide binding]; other site 1159203001265 anticodon binding site; other site 1159203001266 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1159203001267 substrate binding site [chemical binding]; other site 1159203001268 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1159203001269 substrate binding site [chemical binding]; other site 1159203001270 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1159203001271 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1159203001272 catalytic tetrad [active] 1159203001273 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1159203001274 trimer interface [polypeptide binding]; other site 1159203001275 active site 1159203001276 G bulge; other site 1159203001277 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1159203001278 trimer interface [polypeptide binding]; other site 1159203001279 active site 1159203001280 G bulge; other site 1159203001281 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1159203001282 SmpB-tmRNA interface; other site 1159203001283 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1159203001284 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1159203001285 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1159203001286 active site 1159203001287 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1159203001288 Amidinotransferase; Region: Amidinotransf; cl12043 1159203001289 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1159203001290 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1159203001291 Sugar specificity; other site 1159203001292 Pyrimidine base specificity; other site 1159203001293 ATP-binding site [chemical binding]; other site 1159203001294 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1159203001295 GTP1/OBG; Region: GTP1_OBG; pfam01018 1159203001296 Obg GTPase; Region: Obg; cd01898 1159203001297 G1 box; other site 1159203001298 GTP/Mg2+ binding site [chemical binding]; other site 1159203001299 Switch I region; other site 1159203001300 G2 box; other site 1159203001301 G3 box; other site 1159203001302 Switch II region; other site 1159203001303 G4 box; other site 1159203001304 G5 box; other site 1159203001305 Obg family GTPase CgtA, C-terminal extension; Region: Obg_CgtA_exten; TIGR03595 1159203001306 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1159203001307 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 1159203001308 interface (dimer of trimers) [polypeptide binding]; other site 1159203001309 Substrate-binding/catalytic site; other site 1159203001310 Zn-binding sites [ion binding]; other site 1159203001311 C4-dicarboxylate transporter/malic acid transport protein; Region: C4dic_mal_tran; pfam03595 1159203001312 gating phenylalanine in ion channel; other site 1159203001313 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 1159203001314 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 1159203001315 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 1159203001316 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1159203001317 ribonuclease R; Region: RNase_R; TIGR02063 1159203001318 RNB domain; Region: RNB; pfam00773 1159203001319 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1159203001320 RNA binding site [nucleotide binding]; other site 1159203001321 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1159203001322 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1159203001323 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1159203001324 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1159203001325 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1159203001326 DNA-binding site [nucleotide binding]; DNA binding site 1159203001327 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1159203001328 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1159203001329 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1159203001330 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1159203001331 tRNA threonylcarbamoyl adenosine modification protein YgjD; Region: T6A_YgjD; TIGR03723 1159203001332 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1159203001333 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1159203001334 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1159203001335 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1159203001336 dimer interface [polypeptide binding]; other site 1159203001337 conserved gate region; other site 1159203001338 putative PBP binding loops; other site 1159203001339 ABC-ATPase subunit interface; other site 1159203001340 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1159203001341 dimer interface [polypeptide binding]; other site 1159203001342 conserved gate region; other site 1159203001343 putative PBP binding loops; other site 1159203001344 ABC-ATPase subunit interface; other site 1159203001345 potential frameshift: common BLAST hit: gi|385326202|ref|YP_005880639.1| ABC-type spermidine/putrescine import ATP-binding protein potA 1159203001346 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1159203001347 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1159203001348 ABC transporter signature motif; other site 1159203001349 Walker B; other site 1159203001350 D-loop; other site 1159203001351 H-loop/switch region; other site 1159203001352 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1159203001353 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1159203001354 Walker A/P-loop; other site 1159203001355 ATP binding site [chemical binding]; other site 1159203001356 Q-loop/lid; other site 1159203001357 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1159203001358 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl17245 1159203001359 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1159203001360 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1159203001361 Zn2+ binding site [ion binding]; other site 1159203001362 Mg2+ binding site [ion binding]; other site 1159203001363 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1159203001364 recombinase A; Provisional; Region: recA; PRK09354 1159203001365 hexamer interface [polypeptide binding]; other site 1159203001366 Walker A motif; other site 1159203001367 ATP binding site [chemical binding]; other site 1159203001368 Walker B motif; other site 1159203001369 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1159203001370 SelR domain; Region: SelR; pfam01641 1159203001371 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1159203001372 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1159203001373 ring oligomerisation interface [polypeptide binding]; other site 1159203001374 ATP/Mg binding site [chemical binding]; other site 1159203001375 stacking interactions; other site 1159203001376 hinge regions; other site 1159203001377 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1159203001378 oligomerisation interface [polypeptide binding]; other site 1159203001379 mobile loop; other site 1159203001380 roof hairpin; other site 1159203001381 pyruvate kinase; Provisional; Region: PRK05826 1159203001382 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1159203001383 domain interfaces; other site 1159203001384 active site 1159203001385 6-phosphofructokinase; Provisional; Region: PRK03202 1159203001386 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1159203001387 active site 1159203001388 ADP/pyrophosphate binding site [chemical binding]; other site 1159203001389 dimerization interface [polypeptide binding]; other site 1159203001390 allosteric effector site; other site 1159203001391 fructose-1,6-bisphosphate binding site; other site 1159203001392 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1159203001393 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1159203001394 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1159203001395 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 1159203001396 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1159203001397 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1159203001398 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1159203001399 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1159203001400 E3 interaction surface; other site 1159203001401 lipoyl attachment site [posttranslational modification]; other site 1159203001402 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1159203001403 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1159203001404 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1159203001405 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1159203001406 alpha subunit interface [polypeptide binding]; other site 1159203001407 TPP binding site [chemical binding]; other site 1159203001408 heterodimer interface [polypeptide binding]; other site 1159203001409 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1159203001410 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1159203001411 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1159203001412 tetramer interface [polypeptide binding]; other site 1159203001413 TPP-binding site [chemical binding]; other site 1159203001414 heterodimer interface [polypeptide binding]; other site 1159203001415 phosphorylation loop region [posttranslational modification] 1159203001416 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1159203001417 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1159203001418 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1159203001419 propionate/acetate kinase; Provisional; Region: PRK12379 1159203001420 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1159203001421 nucleotide binding site [chemical binding]; other site 1159203001422 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1159203001423 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1159203001424 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1159203001425 Domain of unknown function DUF21; Region: DUF21; pfam01595 1159203001426 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1159203001427 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1159203001428 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1159203001429 active site 1159203001430 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1159203001431 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1159203001432 Substrate-binding site [chemical binding]; other site 1159203001433 Substrate specificity [chemical binding]; other site 1159203001434 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1159203001435 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1159203001436 Walker A motif; other site 1159203001437 ATP binding site [chemical binding]; other site 1159203001438 Walker B motif; other site 1159203001439 arginine finger; other site 1159203001440 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1159203001441 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1159203001442 Walker A motif; other site 1159203001443 ATP binding site [chemical binding]; other site 1159203001444 Walker B motif; other site 1159203001445 arginine finger; other site 1159203001446 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1159203001447 ribonuclease III; Reviewed; Region: rnc; PRK00102 1159203001448 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1159203001449 dimerization interface [polypeptide binding]; other site 1159203001450 active site 1159203001451 metal binding site [ion binding]; metal-binding site 1159203001452 putative phosphate acyltransferase; Provisional; Region: PRK05331 1159203001453 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1159203001454 DAK2 domain; Region: Dak2; pfam02734 1159203001455 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1159203001456 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 1159203001457 RNA binding surface [nucleotide binding]; other site 1159203001458 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1159203001459 active site 1159203001460 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1159203001461 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1159203001462 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1159203001463 DHH family; Region: DHH; pfam01368 1159203001464 DHHA1 domain; Region: DHHA1; pfam02272 1159203001465 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1159203001466 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1159203001467 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1159203001468 Ligand Binding Site [chemical binding]; other site 1159203001469 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 1159203001470 EAGR box; Region: EAGR_box; TIGR03834 1159203001471 EAGR box; Region: EAGR_box; TIGR03834 1159203001472 EAGR box; Region: EAGR_box; TIGR03834 1159203001473 EAGR box; Region: EAGR_box; TIGR03834 1159203001474 EAGR box; Region: EAGR_box; TIGR03834 1159203001475 EAGR box; Region: EAGR_box; TIGR03834 1159203001476 EAGR box; Region: EAGR_box; TIGR03834 1159203001477 EAGR box; Region: EAGR_box; TIGR03834 1159203001478 EAGR box; Region: EAGR_box; TIGR03834 1159203001479 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1159203001480 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1159203001481 ATP binding site [chemical binding]; other site 1159203001482 putative Mg++ binding site [ion binding]; other site 1159203001483 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1159203001484 nucleotide binding region [chemical binding]; other site 1159203001485 ATP-binding site [chemical binding]; other site 1159203001486 enolase; Provisional; Region: eno; PRK00077 1159203001487 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1159203001488 dimer interface [polypeptide binding]; other site 1159203001489 metal binding site [ion binding]; metal-binding site 1159203001490 substrate binding pocket [chemical binding]; other site 1159203001491 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1159203001492 HIT family signature motif; other site 1159203001493 catalytic residue [active] 1159203001494 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1159203001495 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 1159203001496 translation elongation factor P; Region: efp; TIGR00038 1159203001497 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1159203001498 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1159203001499 RNA binding site [nucleotide binding]; other site 1159203001500 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1159203001501 RNA binding site [nucleotide binding]; other site 1159203001502 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1159203001503 Walker A/P-loop; other site 1159203001504 ATP binding site [chemical binding]; other site 1159203001505 Q-loop/lid; other site 1159203001506 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1159203001507 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1159203001508 ABC transporter signature motif; other site 1159203001509 Walker B; other site 1159203001510 D-loop; other site 1159203001511 H-loop/switch region; other site 1159203001512 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1159203001513 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1159203001514 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1159203001515 Walker A/P-loop; other site 1159203001516 ATP binding site [chemical binding]; other site 1159203001517 Q-loop/lid; other site 1159203001518 ABC transporter signature motif; other site 1159203001519 Walker B; other site 1159203001520 D-loop; other site 1159203001521 H-loop/switch region; other site 1159203001522 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1159203001523 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1159203001524 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1159203001525 dimer interface [polypeptide binding]; other site 1159203001526 conserved gate region; other site 1159203001527 putative PBP binding loops; other site 1159203001528 ABC-ATPase subunit interface; other site 1159203001529 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1159203001530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1159203001531 dimer interface [polypeptide binding]; other site 1159203001532 conserved gate region; other site 1159203001533 ABC-ATPase subunit interface; other site 1159203001534 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1159203001535 AAA domain; Region: AAA_21; pfam13304 1159203001536 Walker A/P-loop; other site 1159203001537 ATP binding site [chemical binding]; other site 1159203001538 Q-loop/lid; other site 1159203001539 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1159203001540 ABC transporter signature motif; other site 1159203001541 Walker B; other site 1159203001542 D-loop; other site 1159203001543 H-loop/switch region; other site 1159203001544 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1159203001545 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1159203001546 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1159203001547 Walker A/P-loop; other site 1159203001548 ATP binding site [chemical binding]; other site 1159203001549 Q-loop/lid; other site 1159203001550 ABC transporter signature motif; other site 1159203001551 Walker B; other site 1159203001552 D-loop; other site 1159203001553 H-loop/switch region; other site 1159203001554 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1159203001555 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1159203001556 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1159203001557 dimer interface [polypeptide binding]; other site 1159203001558 conserved gate region; other site 1159203001559 putative PBP binding loops; other site 1159203001560 ABC-ATPase subunit interface; other site 1159203001561 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1159203001562 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1159203001563 dimer interface [polypeptide binding]; other site 1159203001564 conserved gate region; other site 1159203001565 putative PBP binding loops; other site 1159203001566 ABC-ATPase subunit interface; other site 1159203001567 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1159203001568 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1159203001569 rRNA interaction site [nucleotide binding]; other site 1159203001570 S8 interaction site; other site 1159203001571 azoreductase; Reviewed; Region: PRK01355 1159203001572 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1159203001573 recombination factor protein RarA; Reviewed; Region: PRK13342 1159203001574 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1159203001575 Walker A motif; other site 1159203001576 ATP binding site [chemical binding]; other site 1159203001577 Walker B motif; other site 1159203001578 arginine finger; other site 1159203001579 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1159203001580 Predicted methyltransferases [General function prediction only]; Region: COG0313 1159203001581 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1159203001582 putative SAM binding site [chemical binding]; other site 1159203001583 putative homodimer interface [polypeptide binding]; other site 1159203001584 Domain of unknown function (DUF373); Region: DUF373; cl12079 1159203001585 OsmC-like protein; Region: OsmC; cl00767 1159203001586 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1159203001587 elongation factor G; Reviewed; Region: PRK00007 1159203001588 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1159203001589 G1 box; other site 1159203001590 putative GEF interaction site [polypeptide binding]; other site 1159203001591 GTP/Mg2+ binding site [chemical binding]; other site 1159203001592 Switch I region; other site 1159203001593 G2 box; other site 1159203001594 G3 box; other site 1159203001595 Switch II region; other site 1159203001596 G4 box; other site 1159203001597 G5 box; other site 1159203001598 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1159203001599 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1159203001600 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1159203001601 30S ribosomal protein S7; Validated; Region: PRK05302 1159203001602 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1159203001603 S17 interaction site [polypeptide binding]; other site 1159203001604 S8 interaction site; other site 1159203001605 16S rRNA interaction site [nucleotide binding]; other site 1159203001606 streptomycin interaction site [chemical binding]; other site 1159203001607 23S rRNA interaction site [nucleotide binding]; other site 1159203001608 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1159203001609 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1159203001610 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1159203001611 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1159203001612 RNA binding surface [nucleotide binding]; other site 1159203001613 Putative peptidase (DUF31); Region: DUF31; pfam01732 1159203001614 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1159203001615 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1159203001616 nucleotide binding site [chemical binding]; other site 1159203001617 Predicted integral membrane protein [Function unknown]; Region: COG0392 1159203001618 Ion channel; Region: Ion_trans_2; pfam07885 1159203001619 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 1159203001620 Amino acid permease; Region: AA_permease_2; pfam13520 1159203001621 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 1159203001622 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 1159203001623 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1159203001624 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1159203001625 ArsC family; Region: ArsC; pfam03960 1159203001626 putative catalytic residues [active] 1159203001627 thiol/disulfide switch; other site 1159203001628 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1159203001629 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1159203001630 active site 1159203001631 HIGH motif; other site 1159203001632 dimer interface [polypeptide binding]; other site 1159203001633 KMSKS motif; other site 1159203001634 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1159203001635 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1159203001636 active site 1159203001637 motif I; other site 1159203001638 motif II; other site 1159203001639 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1159203001640 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1159203001641 active site 1159203001642 motif I; other site 1159203001643 motif II; other site 1159203001644 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1159203001645 motif II; other site 1159203001646 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1159203001647 cytadherence high molecular weight protein 1 N-terminal region; Region: termin_org_HMW1; TIGR03836 1159203001648 EAGR box; Region: EAGR_box; TIGR03834 1159203001649 EAGR box; Region: EAGR_box; TIGR03834 1159203001650 EAGR box; Region: EAGR_box; TIGR03834 1159203001651 EAGR box; Region: EAGR_box; TIGR03834 1159203001652 EAGR box; Region: EAGR_box; TIGR03834 1159203001653 EAGR box; Region: EAGR_box; TIGR03834 1159203001654 GTP-binding protein LepA; Provisional; Region: PRK05433 1159203001655 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1159203001656 G1 box; other site 1159203001657 putative GEF interaction site [polypeptide binding]; other site 1159203001658 GTP/Mg2+ binding site [chemical binding]; other site 1159203001659 Switch I region; other site 1159203001660 G2 box; other site 1159203001661 G3 box; other site 1159203001662 Switch II region; other site 1159203001663 G4 box; other site 1159203001664 G5 box; other site 1159203001665 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1159203001666 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1159203001667 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1159203001668 Protein of unknown function (DUF1600); Region: DUF1600; pfam07667 1159203001669 Protein of unknown function (DUF1600); Region: DUF1600; pfam07667 1159203001670 Protein of unknown function (DUF1600); Region: DUF1600; pfam07667 1159203001671 Protein of unknown function (DUF3713); Region: DUF3713; pfam12506 1159203001672 Protein of unknown function (DUF3713); Region: DUF3713; pfam12506 1159203001673 Thiamine-precursor transporter protein (ThiW); Region: ThiW; cl01952 1159203001674 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1159203001675 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 1159203001676 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 1159203001677 Asp-box motif; other site 1159203001678 catalytic site [active] 1159203001679 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1159203001680 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 1159203001681 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1159203001682 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 1159203001683 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1159203001684 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1159203001685 active site 1159203001686 HIGH motif; other site 1159203001687 nucleotide binding site [chemical binding]; other site 1159203001688 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1159203001689 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1159203001690 active site 1159203001691 KMSKS motif; other site 1159203001692 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1159203001693 tRNA binding surface [nucleotide binding]; other site 1159203001694 anticodon binding site; other site 1159203001695 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1159203001696 G1 box; other site 1159203001697 GTP/Mg2+ binding site [chemical binding]; other site 1159203001698 Switch I region; other site 1159203001699 G2 box; other site 1159203001700 G3 box; other site 1159203001701 Switch II region; other site 1159203001702 G4 box; other site 1159203001703 G5 box; other site 1159203001704 hypothetical protein; Provisional; Region: PRK00523 1159203001705 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1159203001706 TPP-binding site [chemical binding]; other site 1159203001707 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1159203001708 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1159203001709 active site 1159203001710 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 1159203001711 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1159203001712 active site 1159203001713 DNA binding site [nucleotide binding] 1159203001714 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1159203001715 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1159203001716 putative active site [active] 1159203001717 putative metal binding site [ion binding]; other site 1159203001718 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1159203001719 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK00553 1159203001720 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1159203001721 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1159203001722 active site 1159203001723 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1159203001724 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1159203001725 dimerization interface 3.5A [polypeptide binding]; other site 1159203001726 active site 1159203001727 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1159203001728 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13631 1159203001729 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1159203001730 Walker A/P-loop; other site 1159203001731 ATP binding site [chemical binding]; other site 1159203001732 Q-loop/lid; other site 1159203001733 ABC transporter signature motif; other site 1159203001734 Walker B; other site 1159203001735 D-loop; other site 1159203001736 H-loop/switch region; other site 1159203001737 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13632 1159203001738 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1159203001739 Walker A/P-loop; other site 1159203001740 ATP binding site [chemical binding]; other site 1159203001741 Q-loop/lid; other site 1159203001742 ABC transporter signature motif; other site 1159203001743 Walker B; other site 1159203001744 D-loop; other site 1159203001745 H-loop/switch region; other site 1159203001746 phosphoglyceromutase; Provisional; Region: PRK05434 1159203001747 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 1159203001748 triosephosphate isomerase; Provisional; Region: PRK14567 1159203001749 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1159203001750 substrate binding site [chemical binding]; other site 1159203001751 dimer interface [polypeptide binding]; other site 1159203001752 catalytic triad [active] 1159203001753 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1159203001754 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1159203001755 active site 1159203001756 substrate binding site [chemical binding]; other site 1159203001757 metal binding site [ion binding]; metal-binding site 1159203001758 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1159203001759 active site 1159203001760 catalytic motif [active] 1159203001761 Zn binding site [ion binding]; other site 1159203001762 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1159203001763 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1159203001764 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1159203001765 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1159203001766 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1159203001767 intersubunit interface [polypeptide binding]; other site 1159203001768 active site 1159203001769 catalytic residue [active] 1159203001770 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1159203001771 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1159203001772 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1159203001773 TM-ABC transporter signature motif; other site 1159203001774 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1159203001775 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1159203001776 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1159203001777 TM-ABC transporter signature motif; other site 1159203001778 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1159203001779 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1159203001780 Walker A/P-loop; other site 1159203001781 ATP binding site [chemical binding]; other site 1159203001782 Q-loop/lid; other site 1159203001783 ABC transporter signature motif; other site 1159203001784 Walker B; other site 1159203001785 D-loop; other site 1159203001786 H-loop/switch region; other site 1159203001787 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1159203001788 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 1159203001789 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 1159203001790 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 1159203001791 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 1159203001792 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 1159203001793 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 1159203001794 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 1159203001795 GA module; Region: GA; pfam01468 1159203001796 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 1159203001797 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 1159203001798 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 1159203001799 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 1159203001800 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1159203001801 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1159203001802 recombination protein RecR; Reviewed; Region: recR; PRK00076 1159203001803 RecR protein; Region: RecR; pfam02132 1159203001804 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1159203001805 putative active site [active] 1159203001806 putative metal-binding site [ion binding]; other site 1159203001807 tetramer interface [polypeptide binding]; other site 1159203001808 hypothetical protein; Provisional; Region: PRK00587 1159203001809 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05896 1159203001810 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1159203001811 Walker A motif; other site 1159203001812 ATP binding site [chemical binding]; other site 1159203001813 Walker B motif; other site 1159203001814 arginine finger; other site 1159203001815 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1159203001816 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1159203001817 Walker A motif; other site 1159203001818 ATP binding site [chemical binding]; other site 1159203001819 Walker B motif; other site 1159203001820 arginine finger; other site 1159203001821 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1159203001822 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1159203001823 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1159203001824 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1159203001825 GatB domain; Region: GatB_Yqey; pfam02637 1159203001826 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1159203001827 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1159203001828 aspartyl/glutamyl-tRNA amidotransferase subunit C-like protein; Provisional; Region: PRK12821 1159203001829 hypothetical protein; Provisional; Region: PRK09609 1159203001830 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721 1159203001831 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1159203001832 ligand binding site [chemical binding]; other site 1159203001833 active site 1159203001834 UGI interface [polypeptide binding]; other site 1159203001835 catalytic site [active] 1159203001836 replicative DNA helicase; Region: DnaB; TIGR00665 1159203001837 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1159203001838 Walker A motif; other site 1159203001839 ATP binding site [chemical binding]; other site 1159203001840 Walker B motif; other site 1159203001841 DNA binding loops [nucleotide binding] 1159203001842 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1159203001843 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1159203001844 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1159203001845 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1159203001846 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1159203001847 dimer interface [polypeptide binding]; other site 1159203001848 ssDNA binding site [nucleotide binding]; other site 1159203001849 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1159203001850 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1159203001851 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 1159203001852 dimer interface [polypeptide binding]; other site 1159203001853 active site 1159203001854 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 1159203001855 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 1159203001856 active site 1159203001857 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1159203001858 Mg296 protein; Region: Mg296; pfam09644 1159203001859 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1159203001860 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1159203001861 active site 1159203001862 motif I; other site 1159203001863 motif II; other site 1159203001864 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1159203001865 motif II; other site 1159203001866 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1159203001867 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1159203001868 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 1159203001869 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1159203001870 GTP/Mg2+ binding site [chemical binding]; other site 1159203001871 G4 box; other site 1159203001872 G5 box; other site 1159203001873 G1 box; other site 1159203001874 Switch I region; other site 1159203001875 G2 box; other site 1159203001876 G3 box; other site 1159203001877 Switch II region; other site 1159203001878 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1159203001879 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1159203001880 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1159203001881 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1159203001882 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1159203001883 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1159203001884 Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203 1159203001885 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1159203001886 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1159203001887 alphaNTD homodimer interface [polypeptide binding]; other site 1159203001888 alphaNTD - beta interaction site [polypeptide binding]; other site 1159203001889 alphaNTD - beta' interaction site [polypeptide binding]; other site 1159203001890 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1159203001891 30S ribosomal protein S11; Validated; Region: PRK05309 1159203001892 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1159203001893 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1159203001894 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1159203001895 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1159203001896 rRNA binding site [nucleotide binding]; other site 1159203001897 predicted 30S ribosome binding site; other site 1159203001898 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1159203001899 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1159203001900 catalytic residues [active] 1159203001901 DNA topoisomerase I; Validated; Region: PRK05582 1159203001902 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1159203001903 active site 1159203001904 interdomain interaction site; other site 1159203001905 putative metal-binding site [ion binding]; other site 1159203001906 nucleotide binding site [chemical binding]; other site 1159203001907 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1159203001908 domain I; other site 1159203001909 DNA binding groove [nucleotide binding] 1159203001910 phosphate binding site [ion binding]; other site 1159203001911 domain II; other site 1159203001912 domain III; other site 1159203001913 nucleotide binding site [chemical binding]; other site 1159203001914 catalytic site [active] 1159203001915 domain IV; other site 1159203001916 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1159203001917 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1159203001918 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1159203001919 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1159203001920 substrate binding site [chemical binding]; other site 1159203001921 hexamer interface [polypeptide binding]; other site 1159203001922 metal binding site [ion binding]; metal-binding site 1159203001923 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1159203001924 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1159203001925 active site 1159203001926 dimer interface [polypeptide binding]; other site 1159203001927 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1159203001928 dimer interface [polypeptide binding]; other site 1159203001929 active site 1159203001930 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1159203001931 RNA binding site [nucleotide binding]; other site 1159203001932 ribosome small subunit-dependent GTPase A; Region: TIGR00157 1159203001933 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1159203001934 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1159203001935 GTP/Mg2+ binding site [chemical binding]; other site 1159203001936 G4 box; other site 1159203001937 G1 box; other site 1159203001938 Switch I region; other site 1159203001939 G2 box; other site 1159203001940 G3 box; other site 1159203001941 Switch II region; other site 1159203001942 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1159203001943 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1159203001944 active site 1159203001945 ATP binding site [chemical binding]; other site 1159203001946 substrate binding site [chemical binding]; other site 1159203001947 activation loop (A-loop); other site 1159203001948 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1159203001949 active site 1159203001950 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1159203001951 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1159203001952 catalytic site [active] 1159203001953 G-X2-G-X-G-K; other site 1159203001954 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1159203001955 active site 1159203001956 catalytic residues [active] 1159203001957 metal binding site [ion binding]; metal-binding site 1159203001958 Mycoplasma MFS transporter; Region: MFS_Mycoplasma; pfam07672 1159203001959 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1159203001960 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 1159203001961 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1159203001962 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1159203001963 16S rRNA (guanine(527)-N(7))-methyltransferase GidB; Region: gidB; TIGR00138 1159203001964 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 1159203001965 NusG family protein; Region: NusG_myco; TIGR01956 1159203001966 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1159203001967 putative homodimer interface [polypeptide binding]; other site 1159203001968 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1159203001969 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1159203001970 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1159203001971 MULE transposase domain; Region: MULE; pfam10551 1159203001972 Protein of unknown function (DUF2714); Region: DUF2714; pfam10896 1159203001973 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 1159203001974 F0F1 ATP synthase subunit alpha; Validated; Region: PRK07165 1159203001975 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1159203001976 Walker A motif; other site 1159203001977 ATP binding site [chemical binding]; other site 1159203001978 Walker B motif; other site 1159203001979 Putative peptidase (DUF31); Region: DUF31; pfam01732 1159203001980 Putative peptidase (DUF31); Region: DUF31; pfam01732 1159203001981 DNA-directed RNA polymerase subunit delta; Reviewed; Region: PRK02363 1159203001982 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1159203001983 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1159203001984 intersubunit interface [polypeptide binding]; other site 1159203001985 active site 1159203001986 zinc binding site [ion binding]; other site 1159203001987 Na+ binding site [ion binding]; other site 1159203001988 GTP-binding protein YchF; Reviewed; Region: PRK09601 1159203001989 YchF GTPase; Region: YchF; cd01900 1159203001990 G1 box; other site 1159203001991 GTP/Mg2+ binding site [chemical binding]; other site 1159203001992 Switch I region; other site 1159203001993 G2 box; other site 1159203001994 Switch II region; other site 1159203001995 G3 box; other site 1159203001996 G4 box; other site 1159203001997 G5 box; other site 1159203001998 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1159203001999 thymidine kinase; Provisional; Region: PRK04296 1159203002000 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1159203002001 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1159203002002 23S rRNA interface [nucleotide binding]; other site 1159203002003 L7/L12 interface [polypeptide binding]; other site 1159203002004 putative thiostrepton binding site; other site 1159203002005 L25 interface [polypeptide binding]; other site 1159203002006 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1159203002007 mRNA/rRNA interface [nucleotide binding]; other site 1159203002008 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1159203002009 putative active site [active] 1159203002010 catalytic residue [active] 1159203002011 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1159203002012 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1159203002013 Ligand Binding Site [chemical binding]; other site 1159203002014 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1159203002015 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1159203002016 active site 1159203002017 phosphorylation site [posttranslational modification] 1159203002018 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1159203002019 active site 1159203002020 P-loop; other site 1159203002021 phosphorylation site [posttranslational modification] 1159203002022 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1159203002023 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1159203002024 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1159203002025 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1159203002026 active site 1159203002027 catalytic residues [active] 1159203002028 CRISPR-associated protein Cas9/Csn1, subtype II/NMEMI; Region: cas_Csn1; TIGR01865 1159203002029 CRISPR/Cas system-associated protein Cas9; Region: Csn1; cd09643 1159203002030 CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720 1159203002031 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 1159203002032 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1159203002033 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1159203002034 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1159203002035 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1159203002036 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1159203002037 active site 1159203002038 HIGH motif; other site 1159203002039 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1159203002040 KMSKS motif; other site 1159203002041 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 1159203002042 active site 1159203002043 catalytic triad [active] 1159203002044 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1159203002045 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1159203002046 Walker A motif; other site 1159203002047 ATP binding site [chemical binding]; other site 1159203002048 Walker B motif; other site 1159203002049 arginine finger; other site 1159203002050 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1159203002051 MULE transposase domain; Region: MULE; pfam10551 1159203002052 potential frameshift: common BLAST hit: gi|385326558|ref|YP_005880995.1| SpoU rRNA methylase family protein 1159203002053 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1159203002054 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1159203002055 potential frameshift: common BLAST hit: gi|385325837|ref|YP_005880275.1| NAD-dependent aldehyde dehydrogenase 1159203002056 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1159203002057 NAD(P) binding site [chemical binding]; other site 1159203002058 catalytic residues [active] 1159203002059 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1159203002060 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1159203002061 potential frameshift: common BLAST hit: gi|71894476|ref|YP_278584.1| ATP synthase F0F1 subunit beta 1159203002062 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1159203002063 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1159203002064 Putative peptidase (DUF31); Region: DUF31; pfam01732 1159203002065 Putative peptidase (DUF31); Region: DUF31; pfam01732 1159203002066 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 1159203002067 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1159203002068 nucleotide binding pocket [chemical binding]; other site 1159203002069 K-X-D-G motif; other site 1159203002070 catalytic site [active] 1159203002071 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1159203002072 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1159203002073 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1159203002074 Dimer interface [polypeptide binding]; other site 1159203002075 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1159203002076 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1159203002077 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1159203002078 ATP binding site [chemical binding]; other site 1159203002079 putative Mg++ binding site [ion binding]; other site 1159203002080 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1159203002081 nucleotide binding region [chemical binding]; other site 1159203002082 ATP-binding site [chemical binding]; other site 1159203002083 Putative peptidase (DUF31); Region: DUF31; pfam01732 1159203002084 Putative peptidase (DUF31); Region: DUF31; pfam01732 1159203002085 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1159203002086 Walker B motif; other site 1159203002087 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1159203002088 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1159203002089 NAD(P) binding site [chemical binding]; other site 1159203002090 catalytic residues [active] 1159203002091 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1159203002092 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1159203002093 Zn2+ binding site [ion binding]; other site 1159203002094 Mg2+ binding site [ion binding]; other site 1159203002095 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1159203002096 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1159203002097 HIGH motif; other site 1159203002098 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1159203002099 active site 1159203002100 KMSKS motif; other site 1159203002101 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 1159203002102 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1159203002103 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1159203002104 homodimer interface [polypeptide binding]; other site 1159203002105 NADP binding site [chemical binding]; other site 1159203002106 substrate binding site [chemical binding]; other site 1159203002107 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 1159203002108 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1159203002109 Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679 1159203002110 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1159203002111 Hpr binding site; other site 1159203002112 active site 1159203002113 homohexamer subunit interaction site [polypeptide binding]; other site 1159203002114 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1159203002115 active site 1159203002116 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1159203002117 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1159203002118 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1159203002119 G1 box; other site 1159203002120 GTP/Mg2+ binding site [chemical binding]; other site 1159203002121 Switch I region; other site 1159203002122 G2 box; other site 1159203002123 Switch II region; other site 1159203002124 G3 box; other site 1159203002125 G4 box; other site 1159203002126 G5 box; other site 1159203002127 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1159203002128 DNA polymerase III subunit delta'; Validated; Region: PRK05818 1159203002129 thymidylate kinase; Validated; Region: tmk; PRK00698 1159203002130 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1159203002131 TMP-binding site; other site 1159203002132 ATP-binding site [chemical binding]; other site 1159203002133 seryl-tRNA synthetase; Provisional; Region: PRK05431 1159203002134 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1159203002135 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1159203002136 dimer interface [polypeptide binding]; other site 1159203002137 active site 1159203002138 motif 1; other site 1159203002139 motif 2; other site 1159203002140 motif 3; other site 1159203002141 DNA gyrase subunit A; Validated; Region: PRK05560 1159203002142 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1159203002143 CAP-like domain; other site 1159203002144 active site 1159203002145 primary dimer interface [polypeptide binding]; other site 1159203002146 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1159203002147 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1159203002148 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1159203002149 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1159203002150 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1159203002151 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1159203002152 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1159203002153 ATP binding site [chemical binding]; other site 1159203002154 Mg2+ binding site [ion binding]; other site 1159203002155 G-X-G motif; other site 1159203002156 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1159203002157 anchoring element; other site 1159203002158 dimer interface [polypeptide binding]; other site 1159203002159 ATP binding site [chemical binding]; other site 1159203002160 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1159203002161 active site 1159203002162 putative metal-binding site [ion binding]; other site 1159203002163 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1159203002164 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1159203002165 HSP70 interaction site [polypeptide binding]; other site 1159203002166 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 1159203002167 putative DNA binding surface [nucleotide binding]; other site 1159203002168 DNA polymerase III beta subunit; Region: POL3Bc; smart00480 1159203002169 dimer interface [polypeptide binding]; other site 1159203002170 beta-clamp/clamp loader binding surface; other site 1159203002171 beta-clamp/translesion DNA polymerase binding surface; other site