-- dump date 20140619_160151 -- class Genbank::misc_feature -- table misc_feature_note -- id note 708616000001 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 708616000002 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 708616000003 P-loop; other site 708616000004 Magnesium ion binding site [ion binding]; other site 708616000005 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 708616000006 Magnesium ion binding site [ion binding]; other site 708616000007 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 708616000008 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 708616000009 Walker A motif; other site 708616000010 ATP binding site [chemical binding]; other site 708616000011 Walker B motif; other site 708616000012 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 708616000013 DnaA box-binding interface [nucleotide binding]; other site 708616000014 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 708616000015 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 708616000016 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 708616000017 Walker A/P-loop; other site 708616000018 ATP binding site [chemical binding]; other site 708616000019 Q-loop/lid; other site 708616000020 ABC transporter signature motif; other site 708616000021 Walker B; other site 708616000022 D-loop; other site 708616000023 H-loop/switch region; other site 708616000024 MGF_0026f; Potential ABC-type multidrug/protein/lipid (MdlB-like) transport system component gene region; this gene is intact in strain R(low) but is comprised of 3 CDS regions in strain F 708616000025 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 708616000026 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 708616000027 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 708616000028 Walker A/P-loop; other site 708616000029 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 708616000030 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 708616000031 Q-loop/lid; other site 708616000032 ABC transporter signature motif; other site 708616000033 Walker B; other site 708616000034 D-loop; other site 708616000035 H-loop/switch region; other site 708616000036 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 708616000037 Ribonuclease P; Region: Ribonuclease_P; pfam00825 708616000038 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02201 708616000039 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 708616000040 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 708616000041 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 708616000042 S-adenosylmethionine binding site [chemical binding]; other site 708616000043 hypothetical protein; Provisional; Region: PRK05905 708616000044 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 708616000045 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 708616000046 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 708616000047 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 708616000048 active site 708616000049 HIGH motif; other site 708616000050 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 708616000051 KMSK motif region; other site 708616000052 tRNA binding surface [nucleotide binding]; other site 708616000053 DALR anticodon binding domain; Region: DALR_1; smart00836 708616000054 anticodon binding site; other site 708616000055 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 708616000056 putative catalytic site [active] 708616000057 putative metal binding site [ion binding]; other site 708616000058 putative phosphate binding site [ion binding]; other site 708616000059 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 708616000060 amphipathic channel; other site 708616000061 Asn-Pro-Ala signature motifs; other site 708616000062 glycerol kinase; Provisional; Region: glpK; PRK00047 708616000063 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 708616000064 N- and C-terminal domain interface [polypeptide binding]; other site 708616000065 active site 708616000066 MgATP binding site [chemical binding]; other site 708616000067 catalytic site [active] 708616000068 metal binding site [ion binding]; metal-binding site 708616000069 glycerol binding site [chemical binding]; other site 708616000070 homotetramer interface [polypeptide binding]; other site 708616000071 homodimer interface [polypeptide binding]; other site 708616000072 FBP binding site [chemical binding]; other site 708616000073 protein IIAGlc interface [polypeptide binding]; other site 708616000074 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 708616000075 hydroxyglutarate oxidase; Provisional; Region: PRK11728 708616000076 Putative peptidase (DUF31); Region: DUF31; pfam01732 708616000077 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 708616000078 Ferritin-like domain; Region: Ferritin; pfam00210 708616000079 dinuclear metal binding motif [ion binding]; other site 708616000080 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 708616000081 Ligand Binding Site [chemical binding]; other site 708616000082 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 708616000083 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 708616000084 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 708616000085 FtsX-like permease family; Region: FtsX; pfam02687 708616000086 FtsX-like permease family; Region: FtsX; pfam02687 708616000087 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 708616000088 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 708616000089 Walker A/P-loop; other site 708616000090 ATP binding site [chemical binding]; other site 708616000091 Q-loop/lid; other site 708616000092 ABC transporter signature motif; other site 708616000093 Walker B; other site 708616000094 D-loop; other site 708616000095 H-loop/switch region; other site 708616000096 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 708616000097 homotrimer interaction site [polypeptide binding]; other site 708616000098 zinc binding site [ion binding]; other site 708616000099 CDP-binding sites; other site 708616000100 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 708616000101 active site 708616000102 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 708616000103 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 708616000104 Walker A motif; other site 708616000105 ATP binding site [chemical binding]; other site 708616000106 Walker B motif; other site 708616000107 arginine finger; other site 708616000108 Peptidase family M41; Region: Peptidase_M41; pfam01434 708616000109 DAK2 domain; Region: Dak2; cl03685 708616000110 Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]; Region: COG5219 708616000111 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 708616000112 dimerization domain swap beta strand [polypeptide binding]; other site 708616000113 regulatory protein interface [polypeptide binding]; other site 708616000114 active site 708616000115 regulatory phosphorylation site [posttranslational modification]; other site 708616000116 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 708616000117 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 708616000118 TPP-binding site [chemical binding]; other site 708616000119 dimer interface [polypeptide binding]; other site 708616000120 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 708616000121 PYR/PP interface [polypeptide binding]; other site 708616000122 dimer interface [polypeptide binding]; other site 708616000123 TPP binding site [chemical binding]; other site 708616000124 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 708616000125 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12903 708616000126 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 708616000127 Mycoplasma MG185/MG260 protein; Region: Lipoprotein_X; pfam03305 708616000128 Putative mycoplasma lipoprotein, C-terminal region; Region: Lipoprotein_10; pfam03202 708616000129 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 708616000130 Catalytic site; other site 708616000131 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 708616000132 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 708616000133 Walker A/P-loop; other site 708616000134 ATP binding site [chemical binding]; other site 708616000135 Q-loop/lid; other site 708616000136 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 708616000137 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 708616000138 ABC transporter signature motif; other site 708616000139 Walker B; other site 708616000140 D-loop; other site 708616000141 H-loop/switch region; other site 708616000142 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 708616000143 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 708616000144 dimer interface [polypeptide binding]; other site 708616000145 conserved gate region; other site 708616000146 putative PBP binding loops; other site 708616000147 ABC-ATPase subunit interface; other site 708616000148 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 708616000149 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 708616000150 dimer interface [polypeptide binding]; other site 708616000151 conserved gate region; other site 708616000152 putative PBP binding loops; other site 708616000153 ABC-ATPase subunit interface; other site 708616000154 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 708616000155 DHH family; Region: DHH; pfam01368 708616000156 DHHA1 domain; Region: DHHA1; pfam02272 708616000157 excinuclease ABC subunit B; Provisional; Region: PRK05298 708616000158 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 708616000159 ATP binding site [chemical binding]; other site 708616000160 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 708616000161 nucleotide binding region [chemical binding]; other site 708616000162 ATP-binding site [chemical binding]; other site 708616000163 Ultra-violet resistance protein B; Region: UvrB; pfam12344 708616000164 UvrB/uvrC motif; Region: UVR; pfam02151 708616000165 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 708616000166 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 708616000167 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 708616000168 dimer interface [polypeptide binding]; other site 708616000169 conserved gate region; other site 708616000170 putative PBP binding loops; other site 708616000171 ABC-ATPase subunit interface; other site 708616000172 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 708616000173 dimer interface [polypeptide binding]; other site 708616000174 conserved gate region; other site 708616000175 ABC-ATPase subunit interface; other site 708616000176 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 708616000177 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 708616000178 Walker A/P-loop; other site 708616000179 ATP binding site [chemical binding]; other site 708616000180 Q-loop/lid; other site 708616000181 ABC transporter signature motif; other site 708616000182 Walker B; other site 708616000183 D-loop; other site 708616000184 H-loop/switch region; other site 708616000185 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 708616000186 PhoU domain; Region: PhoU; pfam01895 708616000187 PhoU domain; Region: PhoU; pfam01895 708616000188 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07187 708616000189 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 708616000190 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 708616000191 Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867 708616000192 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 708616000193 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 708616000194 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 708616000195 dimer interface [polypeptide binding]; other site 708616000196 putative radical transfer pathway; other site 708616000197 diiron center [ion binding]; other site 708616000198 tyrosyl radical; other site 708616000199 thymidylate synthase; Reviewed; Region: thyA; PRK01827 708616000200 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 708616000201 dimerization interface [polypeptide binding]; other site 708616000202 active site 708616000203 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 708616000204 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 708616000205 folate binding site [chemical binding]; other site 708616000206 NADP+ binding site [chemical binding]; other site 708616000207 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 708616000208 catalytic motif [active] 708616000209 Zn binding site [ion binding]; other site 708616000210 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 708616000211 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 708616000212 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 708616000213 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 708616000214 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 708616000215 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 708616000216 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 708616000217 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 708616000218 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 708616000219 putative translocon binding site; other site 708616000220 protein-rRNA interface [nucleotide binding]; other site 708616000221 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 708616000222 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 708616000223 G-X-X-G motif; other site 708616000224 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 708616000225 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 708616000226 23S rRNA interface [nucleotide binding]; other site 708616000227 5S rRNA interface [nucleotide binding]; other site 708616000228 putative antibiotic binding site [chemical binding]; other site 708616000229 L25 interface [polypeptide binding]; other site 708616000230 L27 interface [polypeptide binding]; other site 708616000231 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 708616000232 23S rRNA interface [nucleotide binding]; other site 708616000233 putative translocon interaction site; other site 708616000234 signal recognition particle (SRP54) interaction site; other site 708616000235 L23 interface [polypeptide binding]; other site 708616000236 trigger factor interaction site; other site 708616000237 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 708616000238 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 708616000239 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 708616000240 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 708616000241 RNA binding site [nucleotide binding]; other site 708616000242 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 708616000243 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 708616000244 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 708616000245 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 708616000246 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 708616000247 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 708616000248 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 708616000249 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 708616000250 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 708616000251 5S rRNA interface [nucleotide binding]; other site 708616000252 L5 interface [polypeptide binding]; other site 708616000253 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 708616000254 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 708616000255 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 708616000256 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 708616000257 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 708616000258 SecY translocase; Region: SecY; pfam00344 708616000259 adenylate kinase; Region: adk; TIGR01351 708616000260 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 708616000261 AMP-binding site [chemical binding]; other site 708616000262 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 708616000263 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 708616000264 active site 708616000265 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 708616000266 tetramer (dimer of dimers) interface [polypeptide binding]; other site 708616000267 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 708616000268 NAD binding site [chemical binding]; other site 708616000269 dimer interface [polypeptide binding]; other site 708616000270 substrate binding site [chemical binding]; other site 708616000271 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 708616000272 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 708616000273 dimer interface [polypeptide binding]; other site 708616000274 putative anticodon binding site; other site 708616000275 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 708616000276 motif 1; other site 708616000277 active site 708616000278 motif 2; other site 708616000279 motif 3; other site 708616000280 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 708616000281 HSP70 interaction site [polypeptide binding]; other site 708616000282 DnaJ domain; Region: DnaJ; pfam00226 708616000283 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 708616000284 heme oxygenase, HugZ family; Region: heme_ox_HugZ; TIGR04109 708616000285 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 708616000286 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 708616000287 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 708616000288 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 708616000289 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 708616000290 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 708616000291 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 708616000292 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 708616000293 16S/18S rRNA binding site [nucleotide binding]; other site 708616000294 S13e-L30e interaction site [polypeptide binding]; other site 708616000295 25S rRNA binding site [nucleotide binding]; other site 708616000296 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 708616000297 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 708616000298 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 708616000299 catalytic residues [active] 708616000300 DNA polymerase III PolC; Validated; Region: polC; PRK00448 708616000301 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 708616000302 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 708616000303 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 708616000304 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 708616000305 elongation factor Ts; Provisional; Region: tsf; PRK09377 708616000306 UBA/TS-N domain; Region: UBA; pfam00627 708616000307 Elongation factor TS; Region: EF_TS; pfam00889 708616000308 Elongation factor TS; Region: EF_TS; pfam00889 708616000309 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 708616000310 putative nucleotide binding site [chemical binding]; other site 708616000311 uridine monophosphate binding site [chemical binding]; other site 708616000312 homohexameric interface [polypeptide binding]; other site 708616000313 ribosome recycling factor; Reviewed; Region: frr; PRK00083 708616000314 Ribosome recycling factor; Region: RRF; pfam01765 708616000315 hinge region; other site 708616000316 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 708616000317 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 708616000318 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 708616000319 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 708616000320 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 708616000321 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 708616000322 Peptidase family M50; Region: Peptidase_M50; pfam02163 708616000323 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 708616000324 active site 708616000325 putative substrate binding region [chemical binding]; other site 708616000326 DNA polymerase III PolC; Validated; Region: polC; PRK00448 708616000327 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 708616000328 active site 708616000329 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 708616000330 active site 708616000331 catalytic site [active] 708616000332 substrate binding site [chemical binding]; other site 708616000333 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 708616000334 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 708616000335 Part of AAA domain; Region: AAA_19; pfam13245 708616000336 AAA domain; Region: AAA_12; pfam13087 708616000337 MGF_0748f; Potential ABC-type transport system protein gene region; this gene is intact in strain R(low) but is comprised of 2 CDS regions in strain F 708616000338 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 708616000339 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 708616000340 Walker A/P-loop; other site 708616000341 ATP binding site [chemical binding]; other site 708616000342 Q-loop/lid; other site 708616000343 ABC transporter signature motif; other site 708616000344 Walker B; other site 708616000345 D-loop; other site 708616000346 H-loop/switch region; other site 708616000347 aromatic cluster surface protein; Region: aro_clust_Mycop; TIGR04313 708616000348 aromatic cluster surface protein; Region: aro_clust_Mycop; TIGR04313 708616000349 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 708616000350 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 708616000351 active site 708616000352 catalytic residues [active] 708616000353 MGF_0810f; Potential unique hypothetical membrane protein gene region 708616000354 transcription termination factor NusA; Region: NusA; TIGR01953 708616000355 NusA N-terminal domain; Region: NusA_N; pfam08529 708616000356 NusA-like KH domain; Region: KH_5; pfam13184 708616000357 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 708616000358 G-X-X-G motif; other site 708616000359 Protein of unknown function (DUF448); Region: DUF448; pfam04296 708616000360 putative RNA binding cleft [nucleotide binding]; other site 708616000361 translation initiation factor IF-2; Region: IF-2; TIGR00487 708616000362 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 708616000363 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 708616000364 G1 box; other site 708616000365 putative GEF interaction site [polypeptide binding]; other site 708616000366 GTP/Mg2+ binding site [chemical binding]; other site 708616000367 Switch I region; other site 708616000368 G2 box; other site 708616000369 G3 box; other site 708616000370 Switch II region; other site 708616000371 G4 box; other site 708616000372 G5 box; other site 708616000373 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 708616000374 Translation-initiation factor 2; Region: IF-2; pfam11987 708616000375 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 708616000376 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 708616000377 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 708616000378 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 708616000379 RNA binding site [nucleotide binding]; other site 708616000380 active site 708616000381 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 708616000382 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 708616000383 active site 708616000384 Riboflavin kinase; Region: Flavokinase; pfam01687 708616000385 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 708616000386 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 708616000387 Ligand Binding Site [chemical binding]; other site 708616000388 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 708616000389 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 708616000390 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 708616000391 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 708616000392 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 708616000393 motif 1; other site 708616000394 active site 708616000395 motif 2; other site 708616000396 motif 3; other site 708616000397 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 708616000398 DHHA1 domain; Region: DHHA1; pfam02272 708616000399 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 708616000400 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 708616000401 S-adenosylmethionine binding site [chemical binding]; other site 708616000402 Peptidase family U32; Region: Peptidase_U32; pfam01136 708616000403 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 708616000404 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 708616000405 Peptidase family U32; Region: Peptidase_U32; pfam01136 708616000406 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 708616000407 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 708616000408 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 708616000409 putative active site [active] 708616000410 substrate binding site [chemical binding]; other site 708616000411 putative cosubstrate binding site; other site 708616000412 catalytic site [active] 708616000413 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 708616000414 substrate binding site [chemical binding]; other site 708616000415 Domain of unknown function(DUF2779); Region: DUF2779; pfam11074 708616000416 Domain of unknown function (DUF386); Region: DUF386; cl01047 708616000417 hypothetical protein; Provisional; Region: PRK12378 708616000418 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 708616000419 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 708616000420 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264 708616000421 active site turn [active] 708616000422 phosphorylation site [posttranslational modification] 708616000423 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 708616000424 HPr interaction site; other site 708616000425 glycerol kinase (GK) interaction site [polypeptide binding]; other site 708616000426 active site 708616000427 phosphorylation site [posttranslational modification] 708616000428 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 708616000429 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 708616000430 tetrameric interface [polypeptide binding]; other site 708616000431 activator binding site; other site 708616000432 NADP binding site [chemical binding]; other site 708616000433 substrate binding site [chemical binding]; other site 708616000434 catalytic residues [active] 708616000435 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 708616000436 peptide chain release factor 1; Validated; Region: prfA; PRK00591 708616000437 PCRF domain; Region: PCRF; pfam03462 708616000438 RF-1 domain; Region: RF-1; pfam00472 708616000439 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 708616000440 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 708616000441 S-adenosylmethionine binding site [chemical binding]; other site 708616000442 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 708616000443 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 708616000444 Recombination protein U; Region: RecU; pfam03838 708616000445 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 708616000446 IHF - DNA interface [nucleotide binding]; other site 708616000447 IHF dimer interface [polypeptide binding]; other site 708616000448 Domain of unknown function (DUF1951); Region: DUF1951; pfam09188 708616000449 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 708616000450 23S rRNA interface [nucleotide binding]; other site 708616000451 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 708616000452 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 708616000453 core dimer interface [polypeptide binding]; other site 708616000454 peripheral dimer interface [polypeptide binding]; other site 708616000455 L10 interface [polypeptide binding]; other site 708616000456 L11 interface [polypeptide binding]; other site 708616000457 putative EF-Tu interaction site [polypeptide binding]; other site 708616000458 putative EF-G interaction site [polypeptide binding]; other site 708616000459 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 708616000460 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 708616000461 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 708616000462 HSP70 interaction site [polypeptide binding]; other site 708616000463 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 708616000464 Zn binding sites [ion binding]; other site 708616000465 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 708616000466 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 708616000467 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 708616000468 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 708616000469 tRNA binding surface [nucleotide binding]; other site 708616000470 anticodon binding site; other site 708616000471 MGF_1101f; Potential DnaJ-like molecular chaperone gene region 708616000472 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 708616000473 potential frameshift: common BLAST hit: gi|294660272|ref|YP_003573366.1| DnaJ-like molecular chaperone 708616000474 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 708616000475 MGF_1109f; Potential conserved hypothetical protein gene region 708616000476 alpha-mannosidase; Provisional; Region: PRK09819 708616000477 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 708616000478 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 708616000479 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 708616000480 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 708616000481 active site 708616000482 HIGH motif; other site 708616000483 KMSKS motif; other site 708616000484 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 708616000485 tRNA binding surface [nucleotide binding]; other site 708616000486 anticodon binding site; other site 708616000487 GTP-binding protein Der; Reviewed; Region: PRK00093 708616000488 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 708616000489 G1 box; other site 708616000490 GTP/Mg2+ binding site [chemical binding]; other site 708616000491 Switch I region; other site 708616000492 G2 box; other site 708616000493 Switch II region; other site 708616000494 G3 box; other site 708616000495 G4 box; other site 708616000496 G5 box; other site 708616000497 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 708616000498 G1 box; other site 708616000499 GTP/Mg2+ binding site [chemical binding]; other site 708616000500 Switch I region; other site 708616000501 G2 box; other site 708616000502 G3 box; other site 708616000503 Switch II region; other site 708616000504 G4 box; other site 708616000505 G5 box; other site 708616000506 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283 708616000507 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 708616000508 CMP-binding site; other site 708616000509 The sites determining sugar specificity; other site 708616000510 DJ-1 family protein; Region: not_thiJ; TIGR01383 708616000511 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 708616000512 conserved cys residue [active] 708616000513 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 708616000514 active site 708616000515 catalytic residues [active] 708616000516 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 708616000517 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 708616000518 coproporphyrinogen III oxidase; Provisional; Region: PRK05904 708616000519 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 708616000520 FeS/SAM binding site; other site 708616000521 HemN C-terminal domain; Region: HemN_C; pfam06969 708616000522 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 708616000523 AAA domain; Region: AAA_23; pfam13476 708616000524 Walker A/P-loop; other site 708616000525 ATP binding site [chemical binding]; other site 708616000526 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 708616000527 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 708616000528 ABC transporter signature motif; other site 708616000529 Walker B; other site 708616000530 D-loop; other site 708616000531 H-loop/switch region; other site 708616000532 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 708616000533 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 708616000534 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 708616000535 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 708616000536 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 708616000537 Protein of unknown function (DUF3217); Region: DUF3217; pfam11506 708616000538 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 708616000539 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 708616000540 active site 708616000541 dimer interface [polypeptide binding]; other site 708616000542 motif 1; other site 708616000543 motif 2; other site 708616000544 motif 3; other site 708616000545 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 708616000546 anticodon binding site; other site 708616000547 pathogenicity island 1 effector protein SipB; Provisional; Region: PRK15374 708616000548 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 708616000549 Phosphotransferase enzyme family; Region: APH; pfam01636 708616000550 active site 708616000551 ATP binding site [chemical binding]; other site 708616000552 substrate binding site [chemical binding]; other site 708616000553 dimer interface [polypeptide binding]; other site 708616000554 Cytadhesin P30/P32; Region: Cytadhesin_P30; pfam07271 708616000555 adhesin P1; Region: termin_org_P1; TIGR03839 708616000556 adhesin P1; Region: termin_org_P1; TIGR03839 708616000557 Trypsin-sensitive surface-exposed protein; Region: CytadhesinP1; pfam12378 708616000558 Cytadhesin P30/P32; Region: Cytadhesin_P30; pfam07271 708616000559 histidyl-tRNA synthetase; Region: hisS; TIGR00442 708616000560 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 708616000561 dimer interface [polypeptide binding]; other site 708616000562 motif 1; other site 708616000563 active site 708616000564 motif 2; other site 708616000565 motif 3; other site 708616000566 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 708616000567 anticodon binding site; other site 708616000568 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 708616000569 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 708616000570 Dimer interface [polypeptide binding]; other site 708616000571 anticodon binding site; other site 708616000572 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 708616000573 homodimer interface [polypeptide binding]; other site 708616000574 motif 1; other site 708616000575 active site 708616000576 motif 2; other site 708616000577 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 708616000578 active site 708616000579 motif 3; other site 708616000580 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 708616000581 HD domain; Region: HD_4; pfam13328 708616000582 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 708616000583 synthetase active site [active] 708616000584 NTP binding site [chemical binding]; other site 708616000585 metal binding site [ion binding]; metal-binding site 708616000586 CTP synthetase; Validated; Region: pyrG; PRK05380 708616000587 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 708616000588 Catalytic site [active] 708616000589 active site 708616000590 UTP binding site [chemical binding]; other site 708616000591 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 708616000592 active site 708616000593 putative oxyanion hole; other site 708616000594 catalytic triad [active] 708616000595 6-carboxyhexanoate--CoA ligase; Region: BioW; cl00625 708616000596 Protein export membrane protein; Region: SecD_SecF; cl14618 708616000597 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 708616000598 active site 708616000599 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 708616000600 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 708616000601 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 708616000602 Amino acid permease; Region: AA_permease_2; pfam13520 708616000603 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 708616000604 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 708616000605 dimerization interface [polypeptide binding]; other site 708616000606 DPS ferroxidase diiron center [ion binding]; other site 708616000607 ion pore; other site 708616000608 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 708616000609 GA module; Region: GA; pfam01468 708616000610 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 708616000611 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 708616000612 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 708616000613 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 708616000614 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 708616000615 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 708616000616 Walker A/P-loop; other site 708616000617 ATP binding site [chemical binding]; other site 708616000618 Q-loop/lid; other site 708616000619 ABC transporter signature motif; other site 708616000620 Walker B; other site 708616000621 D-loop; other site 708616000622 H-loop/switch region; other site 708616000623 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 708616000624 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 708616000625 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 708616000626 TM-ABC transporter signature motif; other site 708616000627 E2 domain of amyloid precursor protein; Region: APP_E2; pfam12925 708616000628 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 708616000629 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 708616000630 TM-ABC transporter signature motif; other site 708616000631 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 708616000632 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 708616000633 intersubunit interface [polypeptide binding]; other site 708616000634 active site 708616000635 catalytic residue [active] 708616000636 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 708616000637 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 708616000638 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 708616000639 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 708616000640 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 708616000641 active site 708616000642 catalytic motif [active] 708616000643 Zn binding site [ion binding]; other site 708616000644 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 708616000645 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 708616000646 active site 708616000647 substrate binding site [chemical binding]; other site 708616000648 metal binding site [ion binding]; metal-binding site 708616000649 triosephosphate isomerase; Provisional; Region: PRK14567 708616000650 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 708616000651 substrate binding site [chemical binding]; other site 708616000652 dimer interface [polypeptide binding]; other site 708616000653 catalytic triad [active] 708616000654 phosphoglyceromutase; Provisional; Region: PRK05434 708616000655 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 708616000656 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13632 708616000657 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 708616000658 Walker A/P-loop; other site 708616000659 ATP binding site [chemical binding]; other site 708616000660 Q-loop/lid; other site 708616000661 ABC transporter signature motif; other site 708616000662 Walker B; other site 708616000663 D-loop; other site 708616000664 H-loop/switch region; other site 708616000665 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13631 708616000666 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 708616000667 Walker A/P-loop; other site 708616000668 ATP binding site [chemical binding]; other site 708616000669 Q-loop/lid; other site 708616000670 ABC transporter signature motif; other site 708616000671 Walker B; other site 708616000672 D-loop; other site 708616000673 H-loop/switch region; other site 708616000674 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 708616000675 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 708616000676 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 708616000677 dimerization interface 3.5A [polypeptide binding]; other site 708616000678 active site 708616000679 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK00553 708616000680 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 708616000681 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 708616000682 active site 708616000683 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 708616000684 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 708616000685 putative active site [active] 708616000686 putative metal binding site [ion binding]; other site 708616000687 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 708616000688 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 708616000689 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 708616000690 active site 708616000691 DNA binding site [nucleotide binding] 708616000692 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 708616000693 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 708616000694 active site 708616000695 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 708616000696 TPP-binding site [chemical binding]; other site 708616000697 hypothetical protein; Provisional; Region: PRK00523 708616000698 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 708616000699 G1 box; other site 708616000700 GTP/Mg2+ binding site [chemical binding]; other site 708616000701 Switch I region; other site 708616000702 G2 box; other site 708616000703 G3 box; other site 708616000704 Switch II region; other site 708616000705 G4 box; other site 708616000706 G5 box; other site 708616000707 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 708616000708 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 708616000709 active site 708616000710 HIGH motif; other site 708616000711 nucleotide binding site [chemical binding]; other site 708616000712 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 708616000713 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 708616000714 active site 708616000715 KMSKS motif; other site 708616000716 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 708616000717 tRNA binding surface [nucleotide binding]; other site 708616000718 anticodon binding site; other site 708616000719 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 708616000720 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 708616000721 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 708616000722 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 708616000723 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 708616000724 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 708616000725 Asp-box motif; other site 708616000726 catalytic site [active] 708616000727 MGF_1750f; Potential conserved hypothetical membrane protein gene region 708616000728 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 708616000729 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 708616000730 Protein of unknown function (DUF3713); Region: DUF3713; pfam12506 708616000731 Protein of unknown function (DUF3713); Region: DUF3713; pfam12506 708616000732 Protein of unknown function (DUF1600); Region: DUF1600; pfam07667 708616000733 Protein of unknown function (DUF1600); Region: DUF1600; pfam07667 708616000734 Protein of unknown function (DUF1600); Region: DUF1600; pfam07667 708616000735 GTP-binding protein LepA; Provisional; Region: PRK05433 708616000736 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 708616000737 G1 box; other site 708616000738 putative GEF interaction site [polypeptide binding]; other site 708616000739 GTP/Mg2+ binding site [chemical binding]; other site 708616000740 Switch I region; other site 708616000741 G2 box; other site 708616000742 G3 box; other site 708616000743 Switch II region; other site 708616000744 G4 box; other site 708616000745 G5 box; other site 708616000746 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 708616000747 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 708616000748 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 708616000749 cytadherence high molecular weight protein 1 N-terminal region; Region: termin_org_HMW1; TIGR03836 708616000750 EAGR box; Region: EAGR_box; TIGR03834 708616000751 EAGR box; Region: EAGR_box; TIGR03834 708616000752 EAGR box; Region: EAGR_box; TIGR03834 708616000753 EAGR box; Region: EAGR_box; TIGR03834 708616000754 EAGR box; Region: EAGR_box; TIGR03834 708616000755 EAGR box; Region: EAGR_box; TIGR03834 708616000756 EAGR box; Region: EAGR_box; TIGR03834 708616000757 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 708616000758 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 708616000759 active site 708616000760 motif I; other site 708616000761 motif II; other site 708616000762 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 708616000763 motif II; other site 708616000764 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 708616000765 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 708616000766 active site 708616000767 motif I; other site 708616000768 motif II; other site 708616000769 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 708616000770 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 708616000771 active site 708616000772 HIGH motif; other site 708616000773 dimer interface [polypeptide binding]; other site 708616000774 KMSKS motif; other site 708616000775 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 708616000776 ArsC family; Region: ArsC; pfam03960 708616000777 putative catalytic residues [active] 708616000778 thiol/disulfide switch; other site 708616000779 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 708616000780 ATP-NAD kinase; Region: NAD_kinase; pfam01513 708616000781 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 708616000782 Amino acid permease; Region: AA_permease_2; pfam13520 708616000783 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 708616000784 Ion channel; Region: Ion_trans_2; pfam07885 708616000785 Predicted integral membrane protein [Function unknown]; Region: COG0392 708616000786 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 708616000787 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 708616000788 nucleotide binding site [chemical binding]; other site 708616000789 Putative peptidase (DUF31); Region: DUF31; pfam01732 708616000790 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 708616000791 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 708616000792 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 708616000793 cytadherence high molecular weight protein 1 N-terminal region; Region: termin_org_HMW1; TIGR03836 708616000794 EAGR box; Region: EAGR_box; TIGR03834 708616000795 EAGR box; Region: EAGR_box; TIGR03834 708616000796 EAGR box; Region: EAGR_box; TIGR03834 708616000797 EAGR box; Region: EAGR_box; TIGR03834 708616000798 EAGR box; Region: EAGR_box; TIGR03834 708616000799 EAGR box; Region: EAGR_box; TIGR03834 708616000800 EAGR box; Region: EAGR_box; TIGR03834 708616000801 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 708616000802 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 708616000803 active site 708616000804 motif I; other site 708616000805 motif II; other site 708616000806 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 708616000807 motif II; other site 708616000808 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 708616000809 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 708616000810 active site 708616000811 motif I; other site 708616000812 motif II; other site 708616000813 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 708616000814 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 708616000815 active site 708616000816 HIGH motif; other site 708616000817 dimer interface [polypeptide binding]; other site 708616000818 KMSKS motif; other site 708616000819 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 708616000820 ArsC family; Region: ArsC; pfam03960 708616000821 putative catalytic residues [active] 708616000822 thiol/disulfide switch; other site 708616000823 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 708616000824 ATP-NAD kinase; Region: NAD_kinase; pfam01513 708616000825 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 708616000826 Amino acid permease; Region: AA_permease_2; pfam13520 708616000827 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 708616000828 Ion channel; Region: Ion_trans_2; pfam07885 708616000829 Predicted integral membrane protein [Function unknown]; Region: COG0392 708616000830 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 708616000831 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 708616000832 nucleotide binding site [chemical binding]; other site 708616000833 Putative peptidase (DUF31); Region: DUF31; pfam01732 708616000834 MGF_2099f; Potential unique hypothetical protein gene region; intact in R strain 708616000835 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 708616000836 MULE transposase domain; Region: MULE; pfam10551 708616000837 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 708616000838 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 708616000839 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 708616000840 RNA binding surface [nucleotide binding]; other site 708616000841 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 708616000842 S17 interaction site [polypeptide binding]; other site 708616000843 S8 interaction site; other site 708616000844 16S rRNA interaction site [nucleotide binding]; other site 708616000845 streptomycin interaction site [chemical binding]; other site 708616000846 23S rRNA interaction site [nucleotide binding]; other site 708616000847 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 708616000848 30S ribosomal protein S7; Validated; Region: PRK05302 708616000849 elongation factor G; Reviewed; Region: PRK00007 708616000850 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 708616000851 G1 box; other site 708616000852 putative GEF interaction site [polypeptide binding]; other site 708616000853 GTP/Mg2+ binding site [chemical binding]; other site 708616000854 Switch I region; other site 708616000855 G2 box; other site 708616000856 G3 box; other site 708616000857 Switch II region; other site 708616000858 G4 box; other site 708616000859 G5 box; other site 708616000860 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 708616000861 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 708616000862 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 708616000863 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 708616000864 OsmC-like protein; Region: OsmC; pfam02566 708616000865 Predicted methyltransferases [General function prediction only]; Region: COG0313 708616000866 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 708616000867 putative SAM binding site [chemical binding]; other site 708616000868 putative homodimer interface [polypeptide binding]; other site 708616000869 recombination factor protein RarA; Reviewed; Region: PRK13342 708616000870 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 708616000871 Walker A motif; other site 708616000872 ATP binding site [chemical binding]; other site 708616000873 Walker B motif; other site 708616000874 arginine finger; other site 708616000875 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 708616000876 azoreductase; Reviewed; Region: PRK01355 708616000877 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 708616000878 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 708616000879 rRNA interaction site [nucleotide binding]; other site 708616000880 S8 interaction site; other site 708616000881 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 708616000882 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 708616000883 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 708616000884 dimer interface [polypeptide binding]; other site 708616000885 conserved gate region; other site 708616000886 putative PBP binding loops; other site 708616000887 ABC-ATPase subunit interface; other site 708616000888 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 708616000889 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 708616000890 dimer interface [polypeptide binding]; other site 708616000891 conserved gate region; other site 708616000892 putative PBP binding loops; other site 708616000893 ABC-ATPase subunit interface; other site 708616000894 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 708616000895 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 708616000896 Walker A/P-loop; other site 708616000897 ATP binding site [chemical binding]; other site 708616000898 Q-loop/lid; other site 708616000899 ABC transporter signature motif; other site 708616000900 Walker B; other site 708616000901 D-loop; other site 708616000902 H-loop/switch region; other site 708616000903 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 708616000904 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 708616000905 AAA domain; Region: AAA_21; pfam13304 708616000906 Walker A/P-loop; other site 708616000907 ATP binding site [chemical binding]; other site 708616000908 Q-loop/lid; other site 708616000909 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 708616000910 ABC transporter signature motif; other site 708616000911 Walker B; other site 708616000912 D-loop; other site 708616000913 H-loop/switch region; other site 708616000914 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 708616000915 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 708616000916 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 708616000917 dimer interface [polypeptide binding]; other site 708616000918 conserved gate region; other site 708616000919 ABC-ATPase subunit interface; other site 708616000920 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 708616000921 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 708616000922 dimer interface [polypeptide binding]; other site 708616000923 conserved gate region; other site 708616000924 putative PBP binding loops; other site 708616000925 ABC-ATPase subunit interface; other site 708616000926 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 708616000927 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 708616000928 Walker A/P-loop; other site 708616000929 ATP binding site [chemical binding]; other site 708616000930 Q-loop/lid; other site 708616000931 ABC transporter signature motif; other site 708616000932 Walker B; other site 708616000933 D-loop; other site 708616000934 H-loop/switch region; other site 708616000935 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 708616000936 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 708616000937 Walker A/P-loop; other site 708616000938 ATP binding site [chemical binding]; other site 708616000939 Q-loop/lid; other site 708616000940 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 708616000941 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 708616000942 ABC transporter signature motif; other site 708616000943 Walker B; other site 708616000944 D-loop; other site 708616000945 H-loop/switch region; other site 708616000946 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 708616000947 translation elongation factor P; Region: efp; TIGR00038 708616000948 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 708616000949 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 708616000950 RNA binding site [nucleotide binding]; other site 708616000951 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 708616000952 RNA binding site [nucleotide binding]; other site 708616000953 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 708616000954 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 708616000955 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 708616000956 HIT family signature motif; other site 708616000957 catalytic residue [active] 708616000958 enolase; Provisional; Region: eno; PRK00077 708616000959 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 708616000960 dimer interface [polypeptide binding]; other site 708616000961 metal binding site [ion binding]; metal-binding site 708616000962 substrate binding pocket [chemical binding]; other site 708616000963 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 708616000964 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 708616000965 ATP binding site [chemical binding]; other site 708616000966 putative Mg++ binding site [ion binding]; other site 708616000967 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 708616000968 nucleotide binding region [chemical binding]; other site 708616000969 ATP-binding site [chemical binding]; other site 708616000970 EAGR box; Region: EAGR_box; TIGR03834 708616000971 EAGR box; Region: EAGR_box; TIGR03834 708616000972 EAGR box; Region: EAGR_box; TIGR03834 708616000973 EAGR box; Region: EAGR_box; TIGR03834 708616000974 EAGR box; Region: EAGR_box; TIGR03834 708616000975 EAGR box; Region: EAGR_box; TIGR03834 708616000976 EAGR box; Region: EAGR_box; TIGR03834 708616000977 EAGR box; Region: EAGR_box; TIGR03834 708616000978 EAGR box; Region: EAGR_box; TIGR03834 708616000979 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 708616000980 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 708616000981 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 708616000982 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 708616000983 Ligand Binding Site [chemical binding]; other site 708616000984 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 708616000985 DHH family; Region: DHH; pfam01368 708616000986 DHHA1 domain; Region: DHHA1; pfam02272 708616000987 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 708616000988 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 708616000989 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 708616000990 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 708616000991 RNA binding surface [nucleotide binding]; other site 708616000992 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 708616000993 active site 708616000994 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 708616000995 DAK2 domain; Region: Dak2; pfam02734 708616000996 putative phosphate acyltransferase; Provisional; Region: PRK05331 708616000997 ribonuclease III; Reviewed; Region: rnc; PRK00102 708616000998 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 708616000999 dimerization interface [polypeptide binding]; other site 708616001000 active site 708616001001 metal binding site [ion binding]; metal-binding site 708616001002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 708616001003 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 708616001004 Walker A motif; other site 708616001005 ATP binding site [chemical binding]; other site 708616001006 Walker B motif; other site 708616001007 arginine finger; other site 708616001008 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 708616001009 AAA domain; Region: AAA_22; pfam13401 708616001010 Walker A motif; other site 708616001011 ATP binding site [chemical binding]; other site 708616001012 Walker B motif; other site 708616001013 arginine finger; other site 708616001014 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 708616001015 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 708616001016 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 708616001017 Substrate-binding site [chemical binding]; other site 708616001018 Substrate specificity [chemical binding]; other site 708616001019 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 708616001020 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 708616001021 Substrate-binding site [chemical binding]; other site 708616001022 Substrate specificity [chemical binding]; other site 708616001023 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 708616001024 Domain of unknown function DUF21; Region: DUF21; pfam01595 708616001025 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 708616001026 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 708616001027 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 708616001028 propionate/acetate kinase; Provisional; Region: PRK12379 708616001029 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 708616001030 nucleotide binding site [chemical binding]; other site 708616001031 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 708616001032 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 708616001033 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 708616001034 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 708616001035 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 708616001036 tetramer interface [polypeptide binding]; other site 708616001037 TPP-binding site [chemical binding]; other site 708616001038 heterodimer interface [polypeptide binding]; other site 708616001039 phosphorylation loop region [posttranslational modification] 708616001040 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 708616001041 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 708616001042 alpha subunit interface [polypeptide binding]; other site 708616001043 TPP binding site [chemical binding]; other site 708616001044 heterodimer interface [polypeptide binding]; other site 708616001045 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 708616001046 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 708616001047 E3 interaction surface; other site 708616001048 lipoyl attachment site [posttranslational modification]; other site 708616001049 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 708616001050 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 708616001051 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 708616001052 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 708616001053 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 708616001054 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 708616001055 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 708616001056 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 708616001057 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 708616001058 6-phosphofructokinase; Provisional; Region: PRK03202 708616001059 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 708616001060 active site 708616001061 ADP/pyrophosphate binding site [chemical binding]; other site 708616001062 dimerization interface [polypeptide binding]; other site 708616001063 allosteric effector site; other site 708616001064 fructose-1,6-bisphosphate binding site; other site 708616001065 pyruvate kinase; Provisional; Region: PRK05826 708616001066 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 708616001067 domain interfaces; other site 708616001068 active site 708616001069 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 708616001070 oligomerisation interface [polypeptide binding]; other site 708616001071 mobile loop; other site 708616001072 roof hairpin; other site 708616001073 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 708616001074 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 708616001075 ring oligomerisation interface [polypeptide binding]; other site 708616001076 ATP/Mg binding site [chemical binding]; other site 708616001077 stacking interactions; other site 708616001078 hinge regions; other site 708616001079 methionine sulfoxide reductase B; Provisional; Region: PRK00222 708616001080 SelR domain; Region: SelR; pfam01641 708616001081 MGF_2638f; Potential transposase gene region 708616001082 Transposase, Mutator family; Region: Transposase_mut; pfam00872 708616001083 MULE transposase domain; Region: MULE; pfam10551 708616001084 MGF_2649f; Potential transposase gene region 708616001085 Transposase, Mutator family; Region: Transposase_mut; pfam00872 708616001086 MULE transposase domain; Region: MULE; pfam10551 708616001087 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 708616001088 recombinase A; Provisional; Region: recA; PRK09354 708616001089 hexamer interface [polypeptide binding]; other site 708616001090 Walker A motif; other site 708616001091 ATP binding site [chemical binding]; other site 708616001092 Walker B motif; other site 708616001093 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 708616001094 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 708616001095 Zn2+ binding site [ion binding]; other site 708616001096 Mg2+ binding site [ion binding]; other site 708616001097 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 708616001098 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 708616001099 Walker A/P-loop; other site 708616001100 ATP binding site [chemical binding]; other site 708616001101 Q-loop/lid; other site 708616001102 AAA domain; Region: AAA_21; pfam13304 708616001103 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 708616001104 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 708616001105 ABC transporter signature motif; other site 708616001106 Walker B; other site 708616001107 D-loop; other site 708616001108 H-loop/switch region; other site 708616001109 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 708616001110 dimer interface [polypeptide binding]; other site 708616001111 conserved gate region; other site 708616001112 putative PBP binding loops; other site 708616001113 ABC-ATPase subunit interface; other site 708616001114 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 708616001115 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 708616001116 dimer interface [polypeptide binding]; other site 708616001117 conserved gate region; other site 708616001118 putative PBP binding loops; other site 708616001119 ABC-ATPase subunit interface; other site 708616001120 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 708616001121 tRNA threonylcarbamoyl adenosine modification protein YgjD; Region: T6A_YgjD; TIGR03723 708616001122 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 708616001123 S-adenosylmethionine synthetase; Validated; Region: PRK05250 708616001124 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 708616001125 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 708616001126 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 708616001127 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 708616001128 DNA-binding site [nucleotide binding]; DNA binding site 708616001129 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 708616001130 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 708616001131 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 708616001132 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 708616001133 ribonuclease R; Region: RNase_R; TIGR02063 708616001134 RNB domain; Region: RNB; pfam00773 708616001135 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 708616001136 RNA binding site [nucleotide binding]; other site 708616001137 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 708616001138 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 708616001139 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 708616001140 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 708616001141 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 708616001142 C4-dicarboxylate transporter/malic acid transport protein; Region: C4dic_mal_tran; pfam03595 708616001143 gating phenylalanine in ion channel; other site 708616001144 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 708616001145 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 708616001146 interface (dimer of trimers) [polypeptide binding]; other site 708616001147 Substrate-binding/catalytic site; other site 708616001148 Zn-binding sites [ion binding]; other site 708616001149 GTPase CgtA; Reviewed; Region: obgE; PRK12297 708616001150 GTP1/OBG; Region: GTP1_OBG; pfam01018 708616001151 Obg GTPase; Region: Obg; cd01898 708616001152 G1 box; other site 708616001153 GTP/Mg2+ binding site [chemical binding]; other site 708616001154 Switch I region; other site 708616001155 G2 box; other site 708616001156 G3 box; other site 708616001157 Switch II region; other site 708616001158 G4 box; other site 708616001159 G5 box; other site 708616001160 Obg family GTPase CgtA, C-terminal extension; Region: Obg_CgtA_exten; TIGR03595 708616001161 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 708616001162 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 708616001163 Sugar specificity; other site 708616001164 Pyrimidine base specificity; other site 708616001165 ATP-binding site [chemical binding]; other site 708616001166 Amidinotransferase; Region: Amidinotransf; cl12043 708616001167 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 708616001168 MULE transposase domain; Region: MULE; pfam10551 708616001169 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 708616001170 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 708616001171 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 708616001172 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 708616001173 active site 708616001174 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 708616001175 SmpB-tmRNA interface; other site 708616001176 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 708616001177 trimer interface [polypeptide binding]; other site 708616001178 active site 708616001179 G bulge; other site 708616001180 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 708616001181 trimer interface [polypeptide binding]; other site 708616001182 active site 708616001183 G bulge; other site 708616001184 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 708616001185 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 708616001186 active site 708616001187 catalytic tetrad [active] 708616001188 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 708616001189 substrate binding site [chemical binding]; other site 708616001190 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 708616001191 substrate binding site [chemical binding]; other site 708616001192 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 708616001193 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 708616001194 HIGH motif; other site 708616001195 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 708616001196 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 708616001197 active site 708616001198 KMSKS motif; other site 708616001199 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 708616001200 tRNA binding surface [nucleotide binding]; other site 708616001201 anticodon binding site; other site 708616001202 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 708616001203 TrkA-N domain; Region: TrkA_N; pfam02254 708616001204 TrkA-C domain; Region: TrkA_C; pfam02080 708616001205 MGF_2954f; Potential variably expressed lipoprotein and hemagglutinin (VlhA) family protein gene region 708616001206 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 708616001207 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 708616001208 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 708616001209 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 708616001210 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 708616001211 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 708616001212 IHF - DNA interface [nucleotide binding]; other site 708616001213 IHF dimer interface [polypeptide binding]; other site 708616001214 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 708616001215 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 708616001216 ATP binding site [chemical binding]; other site 708616001217 Mg2+ binding site [ion binding]; other site 708616001218 G-X-G motif; other site 708616001219 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 708616001220 anchoring element; other site 708616001221 dimer interface [polypeptide binding]; other site 708616001222 ATP binding site [chemical binding]; other site 708616001223 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 708616001224 active site 708616001225 putative metal-binding site [ion binding]; other site 708616001226 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 708616001227 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 708616001228 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 708616001229 CAP-like domain; other site 708616001230 active site 708616001231 primary dimer interface [polypeptide binding]; other site 708616001232 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 708616001233 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 708616001234 ribosome biogenesis GTPase YqeH; Region: GTPase_YqeH; TIGR03597 708616001235 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 708616001236 GTP/Mg2+ binding site [chemical binding]; other site 708616001237 G4 box; other site 708616001238 G5 box; other site 708616001239 G1 box; other site 708616001240 Switch I region; other site 708616001241 G2 box; other site 708616001242 G3 box; other site 708616001243 Switch II region; other site 708616001244 putative nicotinate-nucleotide adenylyltransferase; Validated; Region: nadD; PRK07152 708616001245 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 708616001246 active site 708616001247 (T/H)XGH motif; other site 708616001248 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 708616001249 Zn2+ binding site [ion binding]; other site 708616001250 Mg2+ binding site [ion binding]; other site 708616001251 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 708616001252 MGF_3059f; Potential hypothetical membrane protein gene region 708616001253 AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271 708616001254 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 708616001255 hypothetical protein; Provisional; Region: PRK06148 708616001256 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 708616001257 RNA/DNA hybrid binding site [nucleotide binding]; other site 708616001258 active site 708616001259 cell division protein GpsB; Provisional; Region: PRK14127 708616001260 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 708616001261 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 708616001262 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 708616001263 putative acyl-acceptor binding pocket; other site 708616001264 segregation and condensation protein A/unknown domain fusion protein; Provisional; Region: scpA; PRK00478 708616001265 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 708616001266 folate binding site [chemical binding]; other site 708616001267 NADP+ binding site [chemical binding]; other site 708616001268 ScpA/B protein; Region: ScpA_ScpB; cl00598 708616001269 Selenoprotein S (SelS); Region: Selenoprotein_S; pfam06936 708616001270 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 708616001271 cell division protein MraZ; Reviewed; Region: PRK00326 708616001272 MraZ protein; Region: MraZ; pfam02381 708616001273 MraZ protein; Region: MraZ; pfam02381 708616001274 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 708616001275 MraW methylase family; Region: Methyltransf_5; cl17771 708616001276 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 708616001277 nucleotide binding site [chemical binding]; other site 708616001278 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 708616001279 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39E; cd02424 708616001280 putative active site [active] 708616001281 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 708616001282 Walker A/P-loop; other site 708616001283 ATP binding site [chemical binding]; other site 708616001284 Q-loop/lid; other site 708616001285 ABC transporter signature motif; other site 708616001286 Walker B; other site 708616001287 D-loop; other site 708616001288 H-loop/switch region; other site 708616001289 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 708616001290 GTPase [General function prediction only]; Region: Era; COG1159 708616001291 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 708616001292 G1 box; other site 708616001293 GTP/Mg2+ binding site [chemical binding]; other site 708616001294 Switch I region; other site 708616001295 G2 box; other site 708616001296 Switch II region; other site 708616001297 G3 box; other site 708616001298 G4 box; other site 708616001299 G5 box; other site 708616001300 KH domain; Region: KH_2; pfam07650 708616001301 Recombination protein O N terminal; Region: RecO_N; pfam11967 708616001302 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 708616001303 glycyl-tRNA synthetase; Provisional; Region: PRK04173 708616001304 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 708616001305 motif 1; other site 708616001306 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 708616001307 active site 708616001308 motif 2; other site 708616001309 motif 3; other site 708616001310 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 708616001311 anticodon binding site; other site 708616001312 DNA primase (bacterial type) [DNA replication, recombination, and repair]; Region: DnaG; COG0358 708616001313 CHC2 zinc finger; Region: zf-CHC2; cl17510 708616001314 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 708616001315 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 708616001316 active site 708616001317 metal binding site [ion binding]; metal-binding site 708616001318 interdomain interaction site; other site 708616001319 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 708616001320 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 708616001321 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 708616001322 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 708616001323 DNA binding residues [nucleotide binding] 708616001324 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 708616001325 Family of unknown function (DUF633); Region: DUF633; pfam04816 708616001326 Uncharacterized conserved protein [Function unknown]; Region: COG0327 708616001327 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 708616001328 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 708616001329 NifU-like domain; Region: NifU; cl00484 708616001330 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 708616001331 active site 708616001332 RDD family; Region: RDD; pfam06271 708616001333 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 708616001334 Part of AAA domain; Region: AAA_19; pfam13245 708616001335 Family description; Region: UvrD_C_2; pfam13538 708616001336 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 708616001337 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 708616001338 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 708616001339 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 708616001340 putative active site [active] 708616001341 metal binding site [ion binding]; metal-binding site 708616001342 homodimer binding site [polypeptide binding]; other site 708616001343 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 708616001344 putative active site [active] 708616001345 putative catalytic site [active] 708616001346 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 708616001347 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 708616001348 Walker A/P-loop; other site 708616001349 ATP binding site [chemical binding]; other site 708616001350 Q-loop/lid; other site 708616001351 ABC transporter signature motif; other site 708616001352 Walker B; other site 708616001353 D-loop; other site 708616001354 H-loop/switch region; other site 708616001355 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 708616001356 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 708616001357 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 708616001358 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 708616001359 Walker A motif; other site 708616001360 ATP binding site [chemical binding]; other site 708616001361 Walker B motif; other site 708616001362 arginine finger; other site 708616001363 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 708616001364 trigger factor; Region: tig; TIGR00115 708616001365 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 708616001366 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 708616001367 Protein of unknown function (DUF3196); Region: DUF3196; pfam11428 708616001368 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 708616001369 metal binding site 2 [ion binding]; metal-binding site 708616001370 putative DNA binding helix; other site 708616001371 metal binding site 1 [ion binding]; metal-binding site 708616001372 endonuclease IV; Provisional; Region: PRK01060 708616001373 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 708616001374 AP (apurinic/apyrimidinic) site pocket; other site 708616001375 DNA interaction; other site 708616001376 Metal-binding active site; metal-binding site 708616001377 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 708616001378 Protein of unknown function (DUF464); Region: DUF464; pfam04327 708616001379 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 708616001380 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 708616001381 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 708616001382 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 708616001383 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 708616001384 Walker A/P-loop; other site 708616001385 ATP binding site [chemical binding]; other site 708616001386 Q-loop/lid; other site 708616001387 ABC transporter signature motif; other site 708616001388 Walker B; other site 708616001389 D-loop; other site 708616001390 H-loop/switch region; other site 708616001391 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 708616001392 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 708616001393 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 708616001394 Walker A/P-loop; other site 708616001395 ATP binding site [chemical binding]; other site 708616001396 Q-loop/lid; other site 708616001397 ABC transporter signature motif; other site 708616001398 Walker B; other site 708616001399 D-loop; other site 708616001400 H-loop/switch region; other site 708616001401 MGF_3378f; Potential PTS system mannitol-specific (MtlA)-like IIB domain protein gene region 708616001402 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 708616001403 active site 708616001404 P-loop; other site 708616001405 phosphorylation site [posttranslational modification] 708616001406 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 708616001407 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 708616001408 putative tRNA-binding site [nucleotide binding]; other site 708616001409 B3/4 domain; Region: B3_4; pfam03483 708616001410 tRNA synthetase B5 domain; Region: B5; smart00874 708616001411 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 708616001412 dimer interface [polypeptide binding]; other site 708616001413 motif 1; other site 708616001414 motif 3; other site 708616001415 motif 2; other site 708616001416 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 708616001417 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 708616001418 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 708616001419 dimer interface [polypeptide binding]; other site 708616001420 motif 1; other site 708616001421 active site 708616001422 motif 2; other site 708616001423 motif 3; other site 708616001424 dUTPase; Region: dUTPase_2; pfam08761 708616001425 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 708616001426 active site 708616001427 homodimer interface [polypeptide binding]; other site 708616001428 metal binding site [ion binding]; metal-binding site 708616001429 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 708616001430 23S rRNA binding site [nucleotide binding]; other site 708616001431 L21 binding site [polypeptide binding]; other site 708616001432 L13 binding site [polypeptide binding]; other site 708616001433 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 708616001434 translation initiation factor IF-3; Region: infC; TIGR00168 708616001435 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 708616001436 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 708616001437 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 708616001438 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 708616001439 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 708616001440 GIY-YIG motif/motif A; other site 708616001441 active site 708616001442 catalytic site [active] 708616001443 putative DNA binding site [nucleotide binding]; other site 708616001444 metal binding site [ion binding]; metal-binding site 708616001445 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 708616001446 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 708616001447 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 708616001448 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 708616001449 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 708616001450 TPP-binding site; other site 708616001451 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 708616001452 PYR/PP interface [polypeptide binding]; other site 708616001453 dimer interface [polypeptide binding]; other site 708616001454 TPP binding site [chemical binding]; other site 708616001455 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 708616001456 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 708616001457 dimer interface [polypeptide binding]; other site 708616001458 conserved gate region; other site 708616001459 ABC-ATPase subunit interface; other site 708616001460 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 708616001461 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 708616001462 dimer interface [polypeptide binding]; other site 708616001463 conserved gate region; other site 708616001464 putative PBP binding loops; other site 708616001465 ABC-ATPase subunit interface; other site 708616001466 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 708616001467 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 708616001468 Walker A/P-loop; other site 708616001469 ATP binding site [chemical binding]; other site 708616001470 Q-loop/lid; other site 708616001471 ABC transporter signature motif; other site 708616001472 Walker B; other site 708616001473 D-loop; other site 708616001474 H-loop/switch region; other site 708616001475 TOBE domain; Region: TOBE_2; pfam08402 708616001476 MGF_3519f; Potential alpha amylase superfamily protein gene region 708616001477 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 708616001478 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 708616001479 active site 708616001480 catalytic site [active] 708616001481 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 708616001482 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 708616001483 DNA-binding site [nucleotide binding]; DNA binding site 708616001484 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 708616001485 pullulanase, type I; Region: pulA_typeI; TIGR02104 708616001486 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 708616001487 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 708616001488 Ca binding site [ion binding]; other site 708616001489 active site 708616001490 catalytic site [active] 708616001491 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 708616001492 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 708616001493 active site 708616001494 catalytic site [active] 708616001495 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 708616001496 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 708616001497 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 708616001498 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 708616001499 beta-phosphoglucomutase; Region: bPGM; TIGR01990 708616001500 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 708616001501 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 708616001502 MGF_3612f; Potential VlhA variable lipoprotein family protein gene region 708616001503 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 708616001504 potential frameshift: common BLAST hit: gi|294660445|ref|NP_853208.2| VlhA.1.05 variable lipoprotein family protein 708616001505 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 708616001506 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 708616001507 Cobalamin biosynthesis protein CobN and related Mg-chelatases [Coenzyme metabolism]; Region: CobN; COG1429 708616001508 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 708616001509 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 708616001510 dimer interface [polypeptide binding]; other site 708616001511 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 708616001512 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 708616001513 HSP70 interaction site [polypeptide binding]; other site 708616001514 EAGR box; Region: EAGR_box; TIGR03834 708616001515 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 708616001516 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 708616001517 dimer interface [polypeptide binding]; other site 708616001518 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 708616001519 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 708616001520 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 708616001521 nucleophilic elbow; other site 708616001522 catalytic triad; other site 708616001523 Serine hydrolase (FSH1); Region: FSH1; pfam03959 708616001524 phosphodiesterase; Provisional; Region: PRK12704 708616001525 phosphodiesterase; Provisional; Region: PRK12704 708616001526 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 708616001527 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 708616001528 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 708616001529 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 708616001530 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 708616001531 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 708616001532 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 708616001533 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 708616001534 Protein of unknown function (DUF1664); Region: DUF1664; pfam07889 708616001535 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 708616001536 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 708616001537 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 708616001538 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 708616001539 active site 708616001540 HIGH motif; other site 708616001541 nucleotide binding site [chemical binding]; other site 708616001542 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 708616001543 active site 708616001544 KMSKS motif; other site 708616001545 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 708616001546 tRNA binding surface [nucleotide binding]; other site 708616001547 anticodon binding site; other site 708616001548 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 708616001549 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 708616001550 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 708616001551 S-adenosylmethionine binding site [chemical binding]; other site 708616001552 Amino acid permease; Region: AA_permease_2; pfam13520 708616001553 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 708616001554 Phosphoglycerate kinase; Region: PGK; pfam00162 708616001555 substrate binding site [chemical binding]; other site 708616001556 hinge regions; other site 708616001557 ADP binding site [chemical binding]; other site 708616001558 catalytic site [active] 708616001559 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 708616001560 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 708616001561 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 708616001562 EDD domain protein, DegV family; Region: DegV; TIGR00762 708616001563 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 708616001564 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 708616001565 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00539 708616001566 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 708616001567 gamma subunit interface [polypeptide binding]; other site 708616001568 epsilon subunit interface [polypeptide binding]; other site 708616001569 LBP interface [polypeptide binding]; other site 708616001570 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 708616001571 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 708616001572 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 708616001573 alpha subunit interaction interface [polypeptide binding]; other site 708616001574 Walker A motif; other site 708616001575 ATP binding site [chemical binding]; other site 708616001576 Walker B motif; other site 708616001577 inhibitor binding site; inhibition site 708616001578 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 708616001579 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 708616001580 core domain interface [polypeptide binding]; other site 708616001581 delta subunit interface [polypeptide binding]; other site 708616001582 epsilon subunit interface [polypeptide binding]; other site 708616001583 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 708616001584 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 708616001585 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 708616001586 beta subunit interaction interface [polypeptide binding]; other site 708616001587 Walker A motif; other site 708616001588 ATP binding site [chemical binding]; other site 708616001589 Walker B motif; other site 708616001590 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 708616001591 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 708616001592 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 708616001593 F0F1 ATP synthase subunit B; Validated; Region: PRK06231 708616001594 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 708616001595 ATP synthase subunit C; Region: ATP-synt_C; cl00466 708616001596 ATP synthase A chain; Region: ATP-synt_A; pfam00119 708616001597 Putative peptidase (DUF31); Region: DUF31; pfam01732 708616001598 Peptidase S7, Flavivirus NS3 serine protease; Region: Peptidase_S7; pfam00949 708616001599 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 708616001600 active site 708616001601 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 708616001602 GcpE protein; Region: GcpE; pfam04551 708616001603 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 708616001604 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 708616001605 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 708616001606 23S rRNA interface [nucleotide binding]; other site 708616001607 L3 interface [polypeptide binding]; other site 708616001608 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 708616001609 active site 708616001610 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 708616001611 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 708616001612 dimer interface [polypeptide binding]; other site 708616001613 active site 708616001614 glycine-pyridoxal phosphate binding site [chemical binding]; other site 708616001615 folate binding site [chemical binding]; other site 708616001616 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 708616001617 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 708616001618 active site 708616001619 HIGH motif; other site 708616001620 dimer interface [polypeptide binding]; other site 708616001621 KMSKS motif; other site 708616001622 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 708616001623 RNA binding surface [nucleotide binding]; other site 708616001624 signal recognition particle protein; Provisional; Region: PRK10867 708616001625 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 708616001626 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 708616001627 P loop; other site 708616001628 GTP binding site [chemical binding]; other site 708616001629 Signal peptide binding domain; Region: SRP_SPB; pfam02978 708616001630 OsmC-like protein; Region: OsmC; cl00767 708616001631 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 708616001632 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 708616001633 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 708616001634 Walker A/P-loop; other site 708616001635 ATP binding site [chemical binding]; other site 708616001636 Q-loop/lid; other site 708616001637 ABC transporter signature motif; other site 708616001638 Walker B; other site 708616001639 D-loop; other site 708616001640 H-loop/switch region; other site 708616001641 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 708616001642 HSP70 interaction site [polypeptide binding]; other site 708616001643 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 708616001644 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 708616001645 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 708616001646 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 708616001647 HSP70 interaction site [polypeptide binding]; other site 708616001648 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 708616001649 HSP70 interaction site [polypeptide binding]; other site 708616001650 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00097 708616001651 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 708616001652 FeS assembly protein SufB; Region: sufB; TIGR01980 708616001653 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 708616001654 trimerization site [polypeptide binding]; other site 708616001655 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 708616001656 active site 708616001657 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 708616001658 Aminotransferase class-V; Region: Aminotran_5; pfam00266 708616001659 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 708616001660 catalytic residue [active] 708616001661 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 708616001662 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 708616001663 FeS assembly ATPase SufC; Region: sufC; TIGR01978 708616001664 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 708616001665 Walker A/P-loop; other site 708616001666 ATP binding site [chemical binding]; other site 708616001667 Q-loop/lid; other site 708616001668 ABC transporter signature motif; other site 708616001669 Walker B; other site 708616001670 D-loop; other site 708616001671 H-loop/switch region; other site 708616001672 Protein of unknown function DUF45; Region: DUF45; pfam01863 708616001673 inorganic pyrophosphatase; Provisional; Region: PRK02230 708616001674 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 708616001675 dimer interface [polypeptide binding]; other site 708616001676 substrate binding site [chemical binding]; other site 708616001677 metal binding sites [ion binding]; metal-binding site 708616001678 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 708616001679 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 708616001680 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 708616001681 active site 708616001682 motif I; other site 708616001683 motif II; other site 708616001684 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 708616001685 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 708616001686 active site 708616001687 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 708616001688 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 708616001689 MGF_4140f; Potential ISMHp1-like transposase gene region 708616001690 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 708616001691 MULE transposase domain; Region: MULE; pfam10551 708616001692 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 708616001693 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 708616001694 S-adenosylmethionine binding site [chemical binding]; other site 708616001695 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 708616001696 metal binding site [ion binding]; metal-binding site 708616001697 tRNA synthetases class II (D, K and N); Region: tRNA-synt_2; pfam00152 708616001698 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 708616001699 active site 708616001700 dimer interface [polypeptide binding]; other site 708616001701 motif 2; other site 708616001702 motif 3; other site 708616001703 MGF_4177f; Potential elongation factor G domain protein gene region; this gene region is more fragmented than in strain R(low) 708616001704 potential frameshift: common BLAST hit: gi|71894071|ref|YP_278179.1| elongation factor G 708616001705 Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cl02785 708616001706 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 708616001707 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 708616001708 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 708616001709 Catalytic site [active] 708616001710 MGF_4186f; Potential ABC-type transport system ATPase/permease gene region 708616001711 FtsX-like permease family; Region: FtsX; pfam02687 708616001712 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 708616001713 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 708616001714 Walker A/P-loop; other site 708616001715 ATP binding site [chemical binding]; other site 708616001716 Q-loop/lid; other site 708616001717 ABC transporter signature motif; other site 708616001718 Walker B; other site 708616001719 D-loop; other site 708616001720 H-loop/switch region; other site 708616001721 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 708616001722 MGF_4207f; potential lichenan-specific PTS system component gene region 708616001723 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 708616001724 Elongation factor TS; Region: EF_TS; pfam00889 708616001725 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 708616001726 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 708616001727 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 708616001728 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 708616001729 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 708616001730 Walker A/P-loop; other site 708616001731 ATP binding site [chemical binding]; other site 708616001732 Q-loop/lid; other site 708616001733 ABC transporter signature motif; other site 708616001734 Walker B; other site 708616001735 D-loop; other site 708616001736 H-loop/switch region; other site 708616001737 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 708616001738 substrate binding site; other site 708616001739 dimer interface; other site 708616001740 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 708616001741 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 708616001742 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 708616001743 putative dimer interface [polypeptide binding]; other site 708616001744 putative anticodon binding site; other site 708616001745 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 708616001746 homodimer interface [polypeptide binding]; other site 708616001747 motif 1; other site 708616001748 motif 2; other site 708616001749 active site 708616001750 motif 3; other site 708616001751 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 708616001752 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 708616001753 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 708616001754 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 708616001755 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 708616001756 Soluble P-type ATPase [General function prediction only]; Region: COG4087 708616001757 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 708616001758 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 708616001759 dephospho-CoA kinase; Region: TIGR00152 708616001760 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 708616001761 CoA-binding site [chemical binding]; other site 708616001762 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 708616001763 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 708616001764 DNA binding site [nucleotide binding] 708616001765 catalytic residue [active] 708616001766 H2TH interface [polypeptide binding]; other site 708616001767 putative catalytic residues [active] 708616001768 turnover-facilitating residue; other site 708616001769 intercalation triad [nucleotide binding]; other site 708616001770 8OG recognition residue [nucleotide binding]; other site 708616001771 putative reading head residues; other site 708616001772 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 708616001773 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 708616001774 5'-3' exonuclease; Provisional; Region: PRK14976 708616001775 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 708616001776 active site 708616001777 metal binding site 1 [ion binding]; metal-binding site 708616001778 putative 5' ssDNA interaction site; other site 708616001779 metal binding site 3; metal-binding site 708616001780 metal binding site 2 [ion binding]; metal-binding site 708616001781 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 708616001782 putative DNA binding site [nucleotide binding]; other site 708616001783 putative metal binding site [ion binding]; other site 708616001784 DNA polymerase III DnaE; Validated; Region: dnaE; PRK05898 708616001785 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 708616001786 active site 708616001787 PHP Thumb interface [polypeptide binding]; other site 708616001788 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 708616001789 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 708616001790 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 708616001791 putative tRNA-binding site [nucleotide binding]; other site 708616001792 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 708616001793 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 708616001794 elongation factor Tu; Reviewed; Region: PRK00049 708616001795 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 708616001796 G1 box; other site 708616001797 GEF interaction site [polypeptide binding]; other site 708616001798 GTP/Mg2+ binding site [chemical binding]; other site 708616001799 Switch I region; other site 708616001800 G2 box; other site 708616001801 G3 box; other site 708616001802 Switch II region; other site 708616001803 G4 box; other site 708616001804 G5 box; other site 708616001805 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 708616001806 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 708616001807 Antibiotic Binding Site [chemical binding]; other site 708616001808 acyl carrier protein; Validated; Region: PRK05828 708616001809 prolyl-tRNA synthetase; Provisional; Region: PRK08661 708616001810 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 708616001811 dimer interface [polypeptide binding]; other site 708616001812 motif 1; other site 708616001813 active site 708616001814 motif 2; other site 708616001815 motif 3; other site 708616001816 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 708616001817 anticodon binding site; other site 708616001818 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 708616001819 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 708616001820 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 708616001821 Walker A/P-loop; other site 708616001822 ATP binding site [chemical binding]; other site 708616001823 Q-loop/lid; other site 708616001824 ABC transporter signature motif; other site 708616001825 Walker B; other site 708616001826 D-loop; other site 708616001827 H-loop/switch region; other site 708616001828 High affinity transport system protein p37; Region: Mycoplasma_p37; pfam06646 708616001829 Yip1 domain; Region: Yip1; pfam04893 708616001830 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 708616001831 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 708616001832 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 708616001833 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 708616001834 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 708616001835 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 708616001836 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 708616001837 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 708616001838 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 708616001839 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 708616001840 G-loop; other site 708616001841 DNA binding site [nucleotide binding] 708616001842 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 708616001843 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 708616001844 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 708616001845 RPB10 interaction site [polypeptide binding]; other site 708616001846 RPB11 interaction site [polypeptide binding]; other site 708616001847 RPB3 interaction site [polypeptide binding]; other site 708616001848 RPB12 interaction site [polypeptide binding]; other site 708616001849 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 708616001850 RPB1 interaction site [polypeptide binding]; other site 708616001851 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 708616001852 DJ-1 family protein; Region: not_thiJ; TIGR01383 708616001853 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 708616001854 conserved cys residue [active] 708616001855 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 708616001856 lipoprotein signal peptidase; Provisional; Region: PRK14787 708616001857 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 708616001858 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 708616001859 active site 708616001860 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 708616001861 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 708616001862 trimer interface [polypeptide binding]; other site 708616001863 active site 708616001864 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 708616001865 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 708616001866 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 708616001867 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 708616001868 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 708616001869 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 708616001870 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 708616001871 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 708616001872 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 708616001873 recombination protein RecR; Reviewed; Region: recR; PRK00076 708616001874 RecR protein; Region: RecR; pfam02132 708616001875 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 708616001876 putative active site [active] 708616001877 putative metal-binding site [ion binding]; other site 708616001878 tetramer interface [polypeptide binding]; other site 708616001879 hypothetical protein; Provisional; Region: PRK00587 708616001880 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05896 708616001881 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 708616001882 Walker A motif; other site 708616001883 ATP binding site [chemical binding]; other site 708616001884 Walker B motif; other site 708616001885 arginine finger; other site 708616001886 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 708616001887 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 708616001888 Walker A motif; other site 708616001889 ATP binding site [chemical binding]; other site 708616001890 Walker B motif; other site 708616001891 arginine finger; other site 708616001892 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 708616001893 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 708616001894 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 708616001895 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 708616001896 GatB domain; Region: GatB_Yqey; pfam02637 708616001897 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 708616001898 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 708616001899 aspartyl/glutamyl-tRNA amidotransferase subunit C-like protein; Provisional; Region: PRK12821 708616001900 hypothetical protein; Provisional; Region: PRK09609 708616001901 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721 708616001902 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 708616001903 ligand binding site [chemical binding]; other site 708616001904 active site 708616001905 UGI interface [polypeptide binding]; other site 708616001906 catalytic site [active] 708616001907 replicative DNA helicase; Region: DnaB; TIGR00665 708616001908 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 708616001909 Walker A motif; other site 708616001910 ATP binding site [chemical binding]; other site 708616001911 Walker B motif; other site 708616001912 DNA binding loops [nucleotide binding] 708616001913 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 708616001914 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 708616001915 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 708616001916 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 708616001917 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 708616001918 dimer interface [polypeptide binding]; other site 708616001919 ssDNA binding site [nucleotide binding]; other site 708616001920 tetramer (dimer of dimers) interface [polypeptide binding]; other site 708616001921 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 708616001922 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 708616001923 dimer interface [polypeptide binding]; other site 708616001924 active site 708616001925 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 708616001926 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 708616001927 active site 708616001928 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 708616001929 Mg296 protein; Region: Mg296; pfam09644 708616001930 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 708616001931 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 708616001932 active site 708616001933 motif I; other site 708616001934 motif II; other site 708616001935 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 708616001936 motif II; other site 708616001937 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 708616001938 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 708616001939 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 708616001940 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 708616001941 GTP/Mg2+ binding site [chemical binding]; other site 708616001942 G4 box; other site 708616001943 G5 box; other site 708616001944 G1 box; other site 708616001945 Switch I region; other site 708616001946 G2 box; other site 708616001947 G3 box; other site 708616001948 Switch II region; other site 708616001949 Uncharacterized conserved protein [Function unknown]; Region: COG1284 708616001950 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 708616001951 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 708616001952 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 708616001953 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 708616001954 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 708616001955 Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203 708616001956 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 708616001957 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 708616001958 alphaNTD homodimer interface [polypeptide binding]; other site 708616001959 alphaNTD - beta interaction site [polypeptide binding]; other site 708616001960 alphaNTD - beta' interaction site [polypeptide binding]; other site 708616001961 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 708616001962 30S ribosomal protein S11; Validated; Region: PRK05309 708616001963 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 708616001964 30S ribosomal protein S13; Region: bact_S13; TIGR03631 708616001965 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 708616001966 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 708616001967 rRNA binding site [nucleotide binding]; other site 708616001968 predicted 30S ribosome binding site; other site 708616001969 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 708616001970 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 708616001971 catalytic residues [active] 708616001972 DNA topoisomerase I; Validated; Region: PRK05582 708616001973 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 708616001974 active site 708616001975 interdomain interaction site; other site 708616001976 putative metal-binding site [ion binding]; other site 708616001977 nucleotide binding site [chemical binding]; other site 708616001978 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 708616001979 domain I; other site 708616001980 DNA binding groove [nucleotide binding] 708616001981 phosphate binding site [ion binding]; other site 708616001982 domain II; other site 708616001983 domain III; other site 708616001984 nucleotide binding site [chemical binding]; other site 708616001985 catalytic site [active] 708616001986 domain IV; other site 708616001987 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 708616001988 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 708616001989 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 708616001990 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 708616001991 substrate binding site [chemical binding]; other site 708616001992 hexamer interface [polypeptide binding]; other site 708616001993 metal binding site [ion binding]; metal-binding site 708616001994 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 708616001995 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 708616001996 active site 708616001997 dimer interface [polypeptide binding]; other site 708616001998 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 708616001999 dimer interface [polypeptide binding]; other site 708616002000 active site 708616002001 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 708616002002 RNA binding site [nucleotide binding]; other site 708616002003 ribosome small subunit-dependent GTPase A; Region: TIGR00157 708616002004 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 708616002005 GTPase/Zn-binding domain interface [polypeptide binding]; other site 708616002006 GTP/Mg2+ binding site [chemical binding]; other site 708616002007 G4 box; other site 708616002008 G1 box; other site 708616002009 Switch I region; other site 708616002010 G2 box; other site 708616002011 G3 box; other site 708616002012 Switch II region; other site 708616002013 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 708616002014 Catalytic domain of Protein Kinases; Region: PKc; cd00180 708616002015 active site 708616002016 ATP binding site [chemical binding]; other site 708616002017 substrate binding site [chemical binding]; other site 708616002018 activation loop (A-loop); other site 708616002019 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 708616002020 active site 708616002021 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 708616002022 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 708616002023 catalytic site [active] 708616002024 G-X2-G-X-G-K; other site 708616002025 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 708616002026 active site 708616002027 catalytic residues [active] 708616002028 metal binding site [ion binding]; metal-binding site 708616002029 Mycoplasma MFS transporter; Region: MFS_Mycoplasma; pfam07672 708616002030 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 708616002031 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 708616002032 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 708616002033 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 708616002034 16S rRNA (guanine(527)-N(7))-methyltransferase GidB; Region: gidB; TIGR00138 708616002035 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 708616002036 NusG family protein; Region: NusG_myco; TIGR01956 708616002037 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 708616002038 putative homodimer interface [polypeptide binding]; other site 708616002039 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 708616002040 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 708616002041 Transposase, Mutator family; Region: Transposase_mut; pfam00872 708616002042 MULE transposase domain; Region: MULE; pfam10551 708616002043 Protein of unknown function (DUF2714); Region: DUF2714; pfam10896 708616002044 F0F1 ATP synthase subunit alpha; Validated; Region: PRK07165 708616002045 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 708616002046 Walker A motif; other site 708616002047 ATP binding site [chemical binding]; other site 708616002048 Walker B motif; other site 708616002049 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 708616002050 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 708616002051 Walker A motif; other site 708616002052 ATP binding site [chemical binding]; other site 708616002053 Walker B motif; other site 708616002054 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 708616002055 Putative peptidase (DUF31); Region: DUF31; pfam01732 708616002056 Putative peptidase (DUF31); Region: DUF31; pfam01732 708616002057 DNA-directed RNA polymerase subunit delta; Reviewed; Region: PRK02363 708616002058 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 708616002059 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 708616002060 intersubunit interface [polypeptide binding]; other site 708616002061 active site 708616002062 zinc binding site [ion binding]; other site 708616002063 Na+ binding site [ion binding]; other site 708616002064 GTP-binding protein YchF; Reviewed; Region: PRK09601 708616002065 YchF GTPase; Region: YchF; cd01900 708616002066 G1 box; other site 708616002067 GTP/Mg2+ binding site [chemical binding]; other site 708616002068 Switch I region; other site 708616002069 G2 box; other site 708616002070 Switch II region; other site 708616002071 G3 box; other site 708616002072 G4 box; other site 708616002073 G5 box; other site 708616002074 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 708616002075 thymidine kinase; Provisional; Region: PRK04296 708616002076 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 708616002077 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 708616002078 23S rRNA interface [nucleotide binding]; other site 708616002079 L7/L12 interface [polypeptide binding]; other site 708616002080 putative thiostrepton binding site; other site 708616002081 L25 interface [polypeptide binding]; other site 708616002082 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 708616002083 mRNA/rRNA interface [nucleotide binding]; other site 708616002084 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 708616002085 putative active site [active] 708616002086 catalytic residue [active] 708616002087 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 708616002088 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 708616002089 Ligand Binding Site [chemical binding]; other site 708616002090 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 708616002091 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 708616002092 active site 708616002093 phosphorylation site [posttranslational modification] 708616002094 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 708616002095 active site 708616002096 P-loop; other site 708616002097 phosphorylation site [posttranslational modification] 708616002098 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 708616002099 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 708616002100 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 708616002101 MGF_5191f; Potential unique hypothetical protein gene region; this gene is intact in strain R(low) but is comprised of 2 CDS regions in strain F 708616002102 MGF_5202f; Potential subtilisin-like serine protease gene region 708616002103 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 708616002104 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 708616002105 active site 708616002106 catalytic residues [active] 708616002107 CRISPR/Cas system-associated protein Cas9; Region: Csn1; cd09643 708616002108 CRISPR-associated protein Cas9/Csn1, subtype II/NMEMI; Region: cas_Csn1; TIGR01865 708616002109 CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720 708616002110 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 708616002111 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 708616002112 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 708616002113 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 708616002114 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 708616002115 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 708616002116 active site 708616002117 HIGH motif; other site 708616002118 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 708616002119 KMSKS motif; other site 708616002120 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 708616002121 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 708616002122 active site 708616002123 catalytic triad [active] 708616002124 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 708616002125 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 708616002126 Walker A motif; other site 708616002127 ATP binding site [chemical binding]; other site 708616002128 Walker B motif; other site 708616002129 arginine finger; other site 708616002130 HsdM N-terminal domain; Region: HsdM_N; pfam12161 708616002131 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 708616002132 Methyltransferase domain; Region: Methyltransf_26; pfam13659 708616002133 MGF_5309f; Potential type I restriction-modification system specificity (S) subunit gene region. 708616002134 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 708616002135 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 708616002136 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 708616002137 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 708616002138 MGF_5319f; Potential type I site-specific restriction-modification system restriction (R) subunit (deoxyribonuclease) gene region 708616002139 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 708616002140 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 708616002141 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 708616002142 ATP binding site [chemical binding]; other site 708616002143 putative Mg++ binding site [ion binding]; other site 708616002144 Herpesvirus UL31-like protein; Region: Herpes_UL31; cl17783 708616002145 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 708616002146 Putative peptidase (DUF31); Region: DUF31; pfam01732 708616002147 Putative peptidase (DUF31); Region: DUF31; pfam01732 708616002148 Region encodes amino acid sequences similar to N-terminal regions of conserved hypothetical proteins predicted in M. synoviae 708616002149 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 708616002150 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 708616002151 nucleotide binding pocket [chemical binding]; other site 708616002152 K-X-D-G motif; other site 708616002153 catalytic site [active] 708616002154 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 708616002155 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 708616002156 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 708616002157 Dimer interface [polypeptide binding]; other site 708616002158 methionine sulfoxide reductase A; Provisional; Region: PRK14054 708616002159 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 708616002160 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 708616002161 ATP binding site [chemical binding]; other site 708616002162 putative Mg++ binding site [ion binding]; other site 708616002163 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 708616002164 nucleotide binding region [chemical binding]; other site 708616002165 ATP-binding site [chemical binding]; other site 708616002166 MGF_5522f; Potential conserved hypothetical protein gene region 708616002167 Putative peptidase (DUF31); Region: DUF31; pfam01732 708616002168 Putative peptidase (DUF31); Region: DUF31; pfam01732 708616002169 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 708616002170 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 708616002171 NAD(P) binding site [chemical binding]; other site 708616002172 catalytic residues [active] 708616002173 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 708616002174 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 708616002175 Zn2+ binding site [ion binding]; other site 708616002176 Mg2+ binding site [ion binding]; other site 708616002177 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 708616002178 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 708616002179 HIGH motif; other site 708616002180 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 708616002181 active site 708616002182 KMSKS motif; other site 708616002183 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 708616002184 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 708616002185 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 708616002186 homodimer interface [polypeptide binding]; other site 708616002187 NADP binding site [chemical binding]; other site 708616002188 substrate binding site [chemical binding]; other site 708616002189 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 708616002190 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 708616002191 Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679 708616002192 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 708616002193 Hpr binding site; other site 708616002194 active site 708616002195 homohexamer subunit interaction site [polypeptide binding]; other site 708616002196 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 708616002197 active site 708616002198 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 708616002199 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 708616002200 trmE is a tRNA modification GTPase; Region: trmE; cd04164 708616002201 G1 box; other site 708616002202 GTP/Mg2+ binding site [chemical binding]; other site 708616002203 Switch I region; other site 708616002204 G2 box; other site 708616002205 Switch II region; other site 708616002206 G3 box; other site 708616002207 G4 box; other site 708616002208 G5 box; other site 708616002209 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 708616002210 DNA polymerase III subunit delta'; Validated; Region: PRK05818 708616002211 DNA polymerase III subunit delta'; Validated; Region: PRK08485 708616002212 thymidylate kinase; Validated; Region: tmk; PRK00698 708616002213 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 708616002214 TMP-binding site; other site 708616002215 ATP-binding site [chemical binding]; other site 708616002216 seryl-tRNA synthetase; Provisional; Region: PRK05431 708616002217 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 708616002218 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 708616002219 dimer interface [polypeptide binding]; other site 708616002220 active site 708616002221 motif 1; other site 708616002222 motif 2; other site 708616002223 motif 3; other site 708616002224 DNA gyrase subunit A; Validated; Region: PRK05560 708616002225 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 708616002226 CAP-like domain; other site 708616002227 active site 708616002228 primary dimer interface [polypeptide binding]; other site 708616002229 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 708616002230 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 708616002231 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 708616002232 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 708616002233 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 708616002234 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 708616002235 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 708616002236 ATP binding site [chemical binding]; other site 708616002237 Mg2+ binding site [ion binding]; other site 708616002238 G-X-G motif; other site 708616002239 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 708616002240 anchoring element; other site 708616002241 dimer interface [polypeptide binding]; other site 708616002242 ATP binding site [chemical binding]; other site 708616002243 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 708616002244 active site 708616002245 putative metal-binding site [ion binding]; other site 708616002246 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 708616002247 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 708616002248 HSP70 interaction site [polypeptide binding]; other site 708616002249 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 708616002250 putative DNA binding surface [nucleotide binding]; other site 708616002251 DNA polymerase III beta subunit; Region: POL3Bc; smart00480 708616002252 dimer interface [polypeptide binding]; other site 708616002253 beta-clamp/clamp loader binding surface; other site 708616002254 beta-clamp/translesion DNA polymerase binding surface; other site