-- dump date 20140619_160416 -- class Genbank::misc_feature -- table misc_feature_note -- id note 710127000001 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 710127000002 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 710127000003 P-loop; other site 710127000004 Magnesium ion binding site [ion binding]; other site 710127000005 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 710127000006 Magnesium ion binding site [ion binding]; other site 710127000007 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 710127000008 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710127000009 Walker A motif; other site 710127000010 ATP binding site [chemical binding]; other site 710127000011 Walker B motif; other site 710127000012 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 710127000013 DnaA box-binding interface [nucleotide binding]; other site 710127000014 Potential MGA_0625 ABC-type multidrug/protein/lipid (MdlB-like) transport system component gene region; MGRL004 710127000015 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 710127000016 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 710127000017 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 710127000018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710127000019 Walker A/P-loop; other site 710127000020 ATP binding site [chemical binding]; other site 710127000021 Q-loop/lid; other site 710127000022 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 710127000023 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 710127000024 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 710127000025 Walker A/P-loop; other site 710127000026 ATP binding site [chemical binding]; other site 710127000027 Q-loop/lid; other site 710127000028 ABC transporter signature motif; other site 710127000029 Walker B; other site 710127000030 D-loop; other site 710127000031 H-loop/switch region; other site 710127000032 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 710127000033 Ribonuclease P; Region: Ribonuclease_P; pfam00825 710127000034 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02201 710127000035 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 710127000036 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 710127000037 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710127000038 S-adenosylmethionine binding site [chemical binding]; other site 710127000039 hypothetical protein; Provisional; Region: PRK05905 710127000040 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 710127000041 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 710127000042 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 710127000043 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 710127000044 active site 710127000045 HIGH motif; other site 710127000046 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 710127000047 KMSK motif region; other site 710127000048 tRNA binding surface [nucleotide binding]; other site 710127000049 DALR anticodon binding domain; Region: DALR_1; smart00836 710127000050 anticodon binding site; other site 710127000051 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 710127000052 putative catalytic site [active] 710127000053 putative metal binding site [ion binding]; other site 710127000054 putative phosphate binding site [ion binding]; other site 710127000055 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 710127000056 amphipathic channel; other site 710127000057 Asn-Pro-Ala signature motifs; other site 710127000058 glycerol kinase; Provisional; Region: glpK; PRK00047 710127000059 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 710127000060 N- and C-terminal domain interface [polypeptide binding]; other site 710127000061 active site 710127000062 MgATP binding site [chemical binding]; other site 710127000063 catalytic site [active] 710127000064 metal binding site [ion binding]; metal-binding site 710127000065 glycerol binding site [chemical binding]; other site 710127000066 homotetramer interface [polypeptide binding]; other site 710127000067 homodimer interface [polypeptide binding]; other site 710127000068 FBP binding site [chemical binding]; other site 710127000069 protein IIAGlc interface [polypeptide binding]; other site 710127000070 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 710127000071 hydroxyglutarate oxidase; Provisional; Region: PRK11728 710127000072 Putative peptidase (DUF31); Region: DUF31; pfam01732 710127000073 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 710127000074 Ferritin-like domain; Region: Ferritin; pfam00210 710127000075 dinuclear metal binding motif [ion binding]; other site 710127000076 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 710127000077 Ligand Binding Site [chemical binding]; other site 710127000078 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 710127000079 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 710127000080 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 710127000081 FtsX-like permease family; Region: FtsX; pfam02687 710127000082 FtsX-like permease family; Region: FtsX; pfam02687 710127000083 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 710127000084 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 710127000085 Walker A/P-loop; other site 710127000086 ATP binding site [chemical binding]; other site 710127000087 Q-loop/lid; other site 710127000088 ABC transporter signature motif; other site 710127000089 Walker B; other site 710127000090 D-loop; other site 710127000091 H-loop/switch region; other site 710127000092 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 710127000093 homotrimer interaction site [polypeptide binding]; other site 710127000094 zinc binding site [ion binding]; other site 710127000095 CDP-binding sites; other site 710127000096 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 710127000097 active site 710127000098 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 710127000099 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710127000100 Walker A motif; other site 710127000101 ATP binding site [chemical binding]; other site 710127000102 Walker B motif; other site 710127000103 arginine finger; other site 710127000104 Peptidase family M41; Region: Peptidase_M41; pfam01434 710127000105 DAK2 domain; Region: Dak2; pfam02734 710127000106 Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]; Region: COG5219 710127000107 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 710127000108 dimerization domain swap beta strand [polypeptide binding]; other site 710127000109 regulatory protein interface [polypeptide binding]; other site 710127000110 active site 710127000111 regulatory phosphorylation site [posttranslational modification]; other site 710127000112 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 710127000113 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 710127000114 TPP-binding site [chemical binding]; other site 710127000115 dimer interface [polypeptide binding]; other site 710127000116 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 710127000117 PYR/PP interface [polypeptide binding]; other site 710127000118 dimer interface [polypeptide binding]; other site 710127000119 TPP binding site [chemical binding]; other site 710127000120 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 710127000121 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12903 710127000122 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 710127000123 Mycoplasma MG185/MG260 protein; Region: Lipoprotein_X; pfam03305 710127000124 Putative mycoplasma lipoprotein, C-terminal region; Region: Lipoprotein_10; pfam03202 710127000125 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 710127000126 Catalytic site; other site 710127000127 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 710127000128 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710127000129 Walker A/P-loop; other site 710127000130 ATP binding site [chemical binding]; other site 710127000131 Q-loop/lid; other site 710127000132 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 710127000133 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710127000134 ABC transporter signature motif; other site 710127000135 Walker B; other site 710127000136 D-loop; other site 710127000137 H-loop/switch region; other site 710127000138 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 710127000139 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710127000140 dimer interface [polypeptide binding]; other site 710127000141 conserved gate region; other site 710127000142 putative PBP binding loops; other site 710127000143 ABC-ATPase subunit interface; other site 710127000144 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 710127000145 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710127000146 dimer interface [polypeptide binding]; other site 710127000147 conserved gate region; other site 710127000148 putative PBP binding loops; other site 710127000149 ABC-ATPase subunit interface; other site 710127000150 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 710127000151 DHH family; Region: DHH; pfam01368 710127000152 DHHA1 domain; Region: DHHA1; pfam02272 710127000153 excinuclease ABC subunit B; Provisional; Region: PRK05298 710127000154 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710127000155 ATP binding site [chemical binding]; other site 710127000156 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710127000157 nucleotide binding region [chemical binding]; other site 710127000158 ATP-binding site [chemical binding]; other site 710127000159 Ultra-violet resistance protein B; Region: UvrB; pfam12344 710127000160 UvrB/uvrC motif; Region: UVR; pfam02151 710127000161 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 710127000162 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 710127000163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710127000164 dimer interface [polypeptide binding]; other site 710127000165 conserved gate region; other site 710127000166 putative PBP binding loops; other site 710127000167 ABC-ATPase subunit interface; other site 710127000168 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710127000169 dimer interface [polypeptide binding]; other site 710127000170 conserved gate region; other site 710127000171 ABC-ATPase subunit interface; other site 710127000172 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 710127000173 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 710127000174 Walker A/P-loop; other site 710127000175 ATP binding site [chemical binding]; other site 710127000176 Q-loop/lid; other site 710127000177 ABC transporter signature motif; other site 710127000178 Walker B; other site 710127000179 D-loop; other site 710127000180 H-loop/switch region; other site 710127000181 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 710127000182 PhoU domain; Region: PhoU; pfam01895 710127000183 PhoU domain; Region: PhoU; pfam01895 710127000184 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07187 710127000185 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 710127000186 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 710127000187 Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867 710127000188 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 710127000189 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 710127000190 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 710127000191 dimer interface [polypeptide binding]; other site 710127000192 putative radical transfer pathway; other site 710127000193 diiron center [ion binding]; other site 710127000194 tyrosyl radical; other site 710127000195 thymidylate synthase; Reviewed; Region: thyA; PRK01827 710127000196 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 710127000197 dimerization interface [polypeptide binding]; other site 710127000198 active site 710127000199 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 710127000200 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 710127000201 folate binding site [chemical binding]; other site 710127000202 NADP+ binding site [chemical binding]; other site 710127000203 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 710127000204 catalytic motif [active] 710127000205 Zn binding site [ion binding]; other site 710127000206 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 710127000207 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 710127000208 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 710127000209 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 710127000210 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 710127000211 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 710127000212 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 710127000213 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 710127000214 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 710127000215 putative translocon binding site; other site 710127000216 protein-rRNA interface [nucleotide binding]; other site 710127000217 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 710127000218 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 710127000219 G-X-X-G motif; other site 710127000220 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 710127000221 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 710127000222 23S rRNA interface [nucleotide binding]; other site 710127000223 5S rRNA interface [nucleotide binding]; other site 710127000224 putative antibiotic binding site [chemical binding]; other site 710127000225 L25 interface [polypeptide binding]; other site 710127000226 L27 interface [polypeptide binding]; other site 710127000227 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 710127000228 23S rRNA interface [nucleotide binding]; other site 710127000229 putative translocon interaction site; other site 710127000230 signal recognition particle (SRP54) interaction site; other site 710127000231 L23 interface [polypeptide binding]; other site 710127000232 trigger factor interaction site; other site 710127000233 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 710127000234 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 710127000235 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 710127000236 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 710127000237 RNA binding site [nucleotide binding]; other site 710127000238 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 710127000239 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 710127000240 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 710127000241 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 710127000242 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 710127000243 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 710127000244 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 710127000245 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 710127000246 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 710127000247 5S rRNA interface [nucleotide binding]; other site 710127000248 L5 interface [polypeptide binding]; other site 710127000249 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 710127000250 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 710127000251 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 710127000252 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 710127000253 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 710127000254 SecY translocase; Region: SecY; pfam00344 710127000255 adenylate kinase; Region: adk; TIGR01351 710127000256 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 710127000257 AMP-binding site [chemical binding]; other site 710127000258 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 710127000259 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 710127000260 active site 710127000261 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 710127000262 tetramer (dimer of dimers) interface [polypeptide binding]; other site 710127000263 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 710127000264 NAD binding site [chemical binding]; other site 710127000265 dimer interface [polypeptide binding]; other site 710127000266 substrate binding site [chemical binding]; other site 710127000267 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 710127000268 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 710127000269 dimer interface [polypeptide binding]; other site 710127000270 putative anticodon binding site; other site 710127000271 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 710127000272 motif 1; other site 710127000273 active site 710127000274 motif 2; other site 710127000275 motif 3; other site 710127000276 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 710127000277 HSP70 interaction site [polypeptide binding]; other site 710127000278 DnaJ domain; Region: DnaJ; pfam00226 710127000279 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 710127000280 heme oxygenase, HugZ family; Region: heme_ox_HugZ; TIGR04109 710127000281 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 710127000282 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 710127000283 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 710127000284 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 710127000285 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 710127000286 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 710127000287 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 710127000288 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 710127000289 16S/18S rRNA binding site [nucleotide binding]; other site 710127000290 S13e-L30e interaction site [polypeptide binding]; other site 710127000291 25S rRNA binding site [nucleotide binding]; other site 710127000292 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 710127000293 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 710127000294 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 710127000295 catalytic residues [active] 710127000296 DNA polymerase III PolC; Validated; Region: polC; PRK00448 710127000297 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 710127000298 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 710127000299 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 710127000300 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 710127000301 elongation factor Ts; Provisional; Region: tsf; PRK09377 710127000302 UBA/TS-N domain; Region: UBA; pfam00627 710127000303 putative protein-protein interaction site; other site 710127000304 GFP-loop; other site 710127000305 Elongation factor TS; Region: EF_TS; pfam00889 710127000306 Elongation factor TS; Region: EF_TS; pfam00889 710127000307 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 710127000308 putative nucleotide binding site [chemical binding]; other site 710127000309 uridine monophosphate binding site [chemical binding]; other site 710127000310 homohexameric interface [polypeptide binding]; other site 710127000311 ribosome recycling factor; Reviewed; Region: frr; PRK00083 710127000312 Ribosome recycling factor; Region: RRF; pfam01765 710127000313 hinge region; other site 710127000314 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 710127000315 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 710127000316 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 710127000317 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 710127000318 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 710127000319 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 710127000320 Peptidase family M50; Region: Peptidase_M50; pfam02163 710127000321 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 710127000322 active site 710127000323 putative substrate binding region [chemical binding]; other site 710127000324 DNA polymerase III PolC; Validated; Region: polC; PRK00448 710127000325 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 710127000326 active site 710127000327 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 710127000328 active site 710127000329 catalytic site [active] 710127000330 substrate binding site [chemical binding]; other site 710127000331 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 710127000332 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 710127000333 Part of AAA domain; Region: AAA_19; pfam13245 710127000334 AAA domain; Region: AAA_12; pfam13087 710127000335 Peptidase S8 family domain, uncharacterized subfamily 2; Region: Peptidases_S8_2; cd07488 710127000336 putative catalytic residues [active] 710127000337 putative active site [active] 710127000338 Potential subtilisin-like protease gene region; MGRL101 710127000339 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 710127000340 active site 710127000341 catalytic residues [active] 710127000342 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 710127000343 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 710127000344 Walker A/P-loop; other site 710127000345 ATP binding site [chemical binding]; other site 710127000346 Q-loop/lid; other site 710127000347 ABC transporter signature motif; other site 710127000348 Walker B; other site 710127000349 D-loop; other site 710127000350 H-loop/switch region; other site 710127000351 aromatic cluster surface protein; Region: aro_clust_Mycop; TIGR04313 710127000352 aromatic cluster surface protein; Region: aro_clust_Mycop; TIGR04313 710127000353 aromatic cluster surface protein; Region: aro_clust_Mycop; TIGR04313 710127000354 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 710127000355 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 710127000356 active site 710127000357 catalytic residues [active] 710127000358 Potential MGA_0817 unique hypothetical membrane protein gene region; MGRL113 710127000359 transcription termination factor NusA; Region: NusA; TIGR01953 710127000360 NusA N-terminal domain; Region: NusA_N; pfam08529 710127000361 NusA-like KH domain; Region: KH_5; pfam13184 710127000362 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 710127000363 G-X-X-G motif; other site 710127000364 Protein of unknown function (DUF448); Region: DUF448; pfam04296 710127000365 putative RNA binding cleft [nucleotide binding]; other site 710127000366 translation initiation factor IF-2; Region: IF-2; TIGR00487 710127000367 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 710127000368 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 710127000369 G1 box; other site 710127000370 putative GEF interaction site [polypeptide binding]; other site 710127000371 GTP/Mg2+ binding site [chemical binding]; other site 710127000372 Switch I region; other site 710127000373 G2 box; other site 710127000374 G3 box; other site 710127000375 Switch II region; other site 710127000376 G4 box; other site 710127000377 G5 box; other site 710127000378 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 710127000379 Translation-initiation factor 2; Region: IF-2; pfam11987 710127000380 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 710127000381 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 710127000382 Potential MGA_0829 conserved hypothetical liproprotein gene region; MGRL119 710127000383 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 710127000384 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 710127000385 RNA binding site [nucleotide binding]; other site 710127000386 active site 710127000387 FAD synthase [Coenzyme metabolism]; Region: RibF; COG0196 710127000388 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 710127000389 active site 710127000390 Riboflavin kinase; Region: Flavokinase; pfam01687 710127000391 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 710127000392 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 710127000393 Ligand Binding Site [chemical binding]; other site 710127000394 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 710127000395 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 710127000396 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 710127000397 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 710127000398 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 710127000399 motif 1; other site 710127000400 active site 710127000401 motif 2; other site 710127000402 motif 3; other site 710127000403 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 710127000404 DHHA1 domain; Region: DHHA1; pfam02272 710127000405 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 710127000406 Methyltransferase domain; Region: Methyltransf_18; pfam12847 710127000407 S-adenosylmethionine binding site [chemical binding]; other site 710127000408 Peptidase family U32; Region: Peptidase_U32; pfam01136 710127000409 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 710127000410 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 710127000411 Peptidase family U32; Region: Peptidase_U32; pfam01136 710127000412 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 710127000413 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 710127000414 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 710127000415 putative active site [active] 710127000416 substrate binding site [chemical binding]; other site 710127000417 putative cosubstrate binding site; other site 710127000418 catalytic site [active] 710127000419 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 710127000420 substrate binding site [chemical binding]; other site 710127000421 Domain of unknown function(DUF2779); Region: DUF2779; pfam11074 710127000422 Domain of unknown function (DUF386); Region: DUF386; cl01047 710127000423 hypothetical protein; Provisional; Region: PRK12378 710127000424 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 710127000425 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 710127000426 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264 710127000427 active site turn [active] 710127000428 phosphorylation site [posttranslational modification] 710127000429 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 710127000430 HPr interaction site; other site 710127000431 glycerol kinase (GK) interaction site [polypeptide binding]; other site 710127000432 active site 710127000433 phosphorylation site [posttranslational modification] 710127000434 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 710127000435 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 710127000436 tetrameric interface [polypeptide binding]; other site 710127000437 activator binding site; other site 710127000438 NADP binding site [chemical binding]; other site 710127000439 substrate binding site [chemical binding]; other site 710127000440 catalytic residues [active] 710127000441 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 710127000442 peptide chain release factor 1; Validated; Region: prfA; PRK00591 710127000443 This domain is found in peptide chain release factors; Region: PCRF; smart00937 710127000444 RF-1 domain; Region: RF-1; pfam00472 710127000445 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 710127000446 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710127000447 S-adenosylmethionine binding site [chemical binding]; other site 710127000448 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 710127000449 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 710127000450 Recombination protein U; Region: RecU; pfam03838 710127000451 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 710127000452 IHF - DNA interface [nucleotide binding]; other site 710127000453 IHF dimer interface [polypeptide binding]; other site 710127000454 Domain of unknown function (DUF1951); Region: DUF1951; pfam09188 710127000455 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 710127000456 23S rRNA interface [nucleotide binding]; other site 710127000457 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 710127000458 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 710127000459 core dimer interface [polypeptide binding]; other site 710127000460 peripheral dimer interface [polypeptide binding]; other site 710127000461 L10 interface [polypeptide binding]; other site 710127000462 L11 interface [polypeptide binding]; other site 710127000463 putative EF-Tu interaction site [polypeptide binding]; other site 710127000464 putative EF-G interaction site [polypeptide binding]; other site 710127000465 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 710127000466 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 710127000467 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 710127000468 HSP70 interaction site [polypeptide binding]; other site 710127000469 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 710127000470 substrate binding site [polypeptide binding]; other site 710127000471 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 710127000472 Zn binding sites [ion binding]; other site 710127000473 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 710127000474 substrate binding site [polypeptide binding]; other site 710127000475 dimer interface [polypeptide binding]; other site 710127000476 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 710127000477 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 710127000478 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 710127000479 tRNA binding surface [nucleotide binding]; other site 710127000480 anticodon binding site; other site 710127000481 Potential MGA_0886/85 DnaJ-like molecular chaperone gene region; MGRL163 710127000482 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 710127000483 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 710127000484 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 710127000485 HSP70 interaction site [polypeptide binding]; other site 710127000486 Potential MGA_0889/92 conserved hypothetical protein gene region; MGRL165 710127000487 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 710127000488 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 710127000489 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 710127000490 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 710127000491 active site 710127000492 HIGH motif; other site 710127000493 KMSKS motif; other site 710127000494 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 710127000495 tRNA binding surface [nucleotide binding]; other site 710127000496 anticodon binding site; other site 710127000497 ribosome-associated GTPase EngA; Region: GTPase_EngA; TIGR03594 710127000498 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 710127000499 G1 box; other site 710127000500 GTP/Mg2+ binding site [chemical binding]; other site 710127000501 Switch I region; other site 710127000502 G2 box; other site 710127000503 Switch II region; other site 710127000504 G3 box; other site 710127000505 G4 box; other site 710127000506 G5 box; other site 710127000507 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 710127000508 G1 box; other site 710127000509 GTP/Mg2+ binding site [chemical binding]; other site 710127000510 Switch I region; other site 710127000511 G2 box; other site 710127000512 G3 box; other site 710127000513 Switch II region; other site 710127000514 G4 box; other site 710127000515 G5 box; other site 710127000516 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283 710127000517 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 710127000518 CMP-binding site; other site 710127000519 The sites determining sugar specificity; other site 710127000520 DJ-1 family protein; Region: not_thiJ; TIGR01383 710127000521 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 710127000522 conserved cys residue [active] 710127000523 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 710127000524 active site 710127000525 catalytic residues [active] 710127000526 Potential MGA_0908/11 unique hypothetical membrane protein gene region; MGRL183 710127000527 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 710127000528 MULE transposase domain; Region: MULE; pfam10551 710127000529 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 710127000530 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 710127000531 coproporphyrinogen III oxidase; Provisional; Region: PRK05904 710127000532 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 710127000533 FeS/SAM binding site; other site 710127000534 HemN C-terminal domain; Region: HemN_C; pfam06969 710127000535 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 710127000536 AAA domain; Region: AAA_23; pfam13476 710127000537 Walker A/P-loop; other site 710127000538 ATP binding site [chemical binding]; other site 710127000539 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 710127000540 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 710127000541 ABC transporter signature motif; other site 710127000542 Walker B; other site 710127000543 D-loop; other site 710127000544 H-loop/switch region; other site 710127000545 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 710127000546 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 710127000547 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 710127000548 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2739; cl17893 710127000549 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 710127000550 Protein of unknown function (DUF3217); Region: DUF3217; pfam11506 710127000551 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 710127000552 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 710127000553 active site 710127000554 dimer interface [polypeptide binding]; other site 710127000555 motif 1; other site 710127000556 motif 2; other site 710127000557 motif 3; other site 710127000558 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 710127000559 anticodon binding site; other site 710127000560 pathogenicity island 1 effector protein SipB; Provisional; Region: PRK15374 710127000561 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 710127000562 Phosphotransferase enzyme family; Region: APH; pfam01636 710127000563 active site 710127000564 ATP binding site [chemical binding]; other site 710127000565 substrate binding site [chemical binding]; other site 710127000566 dimer interface [polypeptide binding]; other site 710127000567 Cytadhesin P30/P32; Region: Cytadhesin_P30; pfam07271 710127000568 adhesin P1; Region: termin_org_P1; TIGR03839 710127000569 adhesin P1; Region: termin_org_P1; TIGR03839 710127000570 Trypsin-sensitive surface-exposed protein; Region: CytadhesinP1; pfam12378 710127000571 Cytadhesin P30/P32; Region: Cytadhesin_P30; pfam07271 710127000572 histidyl-tRNA synthetase; Region: hisS; TIGR00442 710127000573 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 710127000574 dimer interface [polypeptide binding]; other site 710127000575 motif 1; other site 710127000576 active site 710127000577 motif 2; other site 710127000578 motif 3; other site 710127000579 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 710127000580 anticodon binding site; other site 710127000581 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 710127000582 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 710127000583 Dimer interface [polypeptide binding]; other site 710127000584 anticodon binding site; other site 710127000585 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 710127000586 homodimer interface [polypeptide binding]; other site 710127000587 motif 1; other site 710127000588 active site 710127000589 motif 2; other site 710127000590 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 710127000591 active site 710127000592 motif 3; other site 710127000593 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 710127000594 HD domain; Region: HD_4; pfam13328 710127000595 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 710127000596 synthetase active site [active] 710127000597 NTP binding site [chemical binding]; other site 710127000598 metal binding site [ion binding]; metal-binding site 710127000599 CTP synthetase; Validated; Region: pyrG; PRK05380 710127000600 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 710127000601 Catalytic site [active] 710127000602 active site 710127000603 UTP binding site [chemical binding]; other site 710127000604 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 710127000605 active site 710127000606 putative oxyanion hole; other site 710127000607 catalytic triad [active] 710127000608 6-carboxyhexanoate--CoA ligase; Region: BioW; cl00625 710127000609 Protein export membrane protein; Region: SecD_SecF; cl14618 710127000610 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 710127000611 active site 710127000612 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 710127000613 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 710127000614 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 710127000615 Amino acid permease; Region: AA_permease_2; pfam13520 710127000616 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 710127000617 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 710127000618 dimerization interface [polypeptide binding]; other site 710127000619 DPS ferroxidase diiron center [ion binding]; other site 710127000620 ion pore; other site 710127000621 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127000622 Potential MGA_0968/70 VlhA.4.03 variable lipoprotein family protein gene region; MGRL220 710127000623 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127000624 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127000625 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127000626 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127000627 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127000628 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127000629 Potential MGA_vlhA.4.07.2a/b variable lipoprotein family protein gene region; MGRL226 710127000630 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127000631 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127000632 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127000633 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127000634 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127000635 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127000636 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127000637 GA module; Region: GA; pfam01468 710127000638 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127000639 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127000640 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 710127000641 trimer interface [polypeptide binding]; other site 710127000642 active site 710127000643 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 710127000644 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 710127000645 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 710127000646 active site 710127000647 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 710127000648 lipoprotein signal peptidase; Provisional; Region: PRK14787 710127000649 DJ-1 family protein; Region: not_thiJ; TIGR01383 710127000650 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 710127000651 conserved cys residue [active] 710127000652 potential MGA_1359 gene region; likely fragment of restriction modification methylase; MGRL243 710127000653 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 710127000654 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 710127000655 nucleophilic elbow; other site 710127000656 catalytic triad; other site 710127000657 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 710127000658 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 710127000659 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 710127000660 RPB10 interaction site [polypeptide binding]; other site 710127000661 RPB11 interaction site [polypeptide binding]; other site 710127000662 RPB3 interaction site [polypeptide binding]; other site 710127000663 RPB12 interaction site [polypeptide binding]; other site 710127000664 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 710127000665 RPB1 interaction site [polypeptide binding]; other site 710127000666 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 710127000667 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 710127000668 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 710127000669 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 710127000670 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 710127000671 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 710127000672 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 710127000673 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 710127000674 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 710127000675 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 710127000676 G-loop; other site 710127000677 DNA binding site [nucleotide binding] 710127000678 Potential MGA_1014/1345 Unique hypothetical protein gene region intact in other M. gallisepticum strains; MGRL250 710127000679 Yip1 domain; Region: Yip1; pfam04893 710127000680 High affinity transport system protein p37; Region: Mycoplasma_p37; pfam06646 710127000681 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 710127000682 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710127000683 Walker A/P-loop; other site 710127000684 ATP binding site [chemical binding]; other site 710127000685 Q-loop/lid; other site 710127000686 ABC transporter signature motif; other site 710127000687 Walker B; other site 710127000688 D-loop; other site 710127000689 H-loop/switch region; other site 710127000690 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 710127000691 prolyl-tRNA synthetase; Provisional; Region: PRK08661 710127000692 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 710127000693 dimer interface [polypeptide binding]; other site 710127000694 motif 1; other site 710127000695 active site 710127000696 motif 2; other site 710127000697 motif 3; other site 710127000698 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 710127000699 anticodon binding site; other site 710127000700 acyl carrier protein; Validated; Region: PRK05828 710127000701 elongation factor Tu; Reviewed; Region: PRK00049 710127000702 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 710127000703 G1 box; other site 710127000704 GEF interaction site [polypeptide binding]; other site 710127000705 GTP/Mg2+ binding site [chemical binding]; other site 710127000706 Switch I region; other site 710127000707 G2 box; other site 710127000708 G3 box; other site 710127000709 Switch II region; other site 710127000710 G4 box; other site 710127000711 G5 box; other site 710127000712 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 710127000713 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 710127000714 Antibiotic Binding Site [chemical binding]; other site 710127000715 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 710127000716 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 710127000717 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 710127000718 putative tRNA-binding site [nucleotide binding]; other site 710127000719 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 710127000720 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 710127000721 DNA polymerase III DnaE; Validated; Region: dnaE; PRK05898 710127000722 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 710127000723 active site 710127000724 PHP Thumb interface [polypeptide binding]; other site 710127000725 5'-3' exonuclease; Provisional; Region: PRK14976 710127000726 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 710127000727 active site 710127000728 metal binding site 1 [ion binding]; metal-binding site 710127000729 putative 5' ssDNA interaction site; other site 710127000730 metal binding site 3; metal-binding site 710127000731 metal binding site 2 [ion binding]; metal-binding site 710127000732 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 710127000733 putative DNA binding site [nucleotide binding]; other site 710127000734 putative metal binding site [ion binding]; other site 710127000735 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 710127000736 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 710127000737 DNA binding site [nucleotide binding] 710127000738 catalytic residue [active] 710127000739 H2TH interface [polypeptide binding]; other site 710127000740 putative catalytic residues [active] 710127000741 turnover-facilitating residue; other site 710127000742 intercalation triad [nucleotide binding]; other site 710127000743 8OG recognition residue [nucleotide binding]; other site 710127000744 putative reading head residues; other site 710127000745 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 710127000746 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 710127000747 dephospho-CoA kinase; Region: TIGR00152 710127000748 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 710127000749 CoA-binding site [chemical binding]; other site 710127000750 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 710127000751 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 710127000752 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 710127000753 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 710127000754 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 710127000755 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 710127000756 Soluble P-type ATPase [General function prediction only]; Region: COG4087 710127000757 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 710127000758 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 710127000759 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 710127000760 putative dimer interface [polypeptide binding]; other site 710127000761 putative anticodon binding site; other site 710127000762 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 710127000763 homodimer interface [polypeptide binding]; other site 710127000764 motif 1; other site 710127000765 motif 2; other site 710127000766 active site 710127000767 motif 3; other site 710127000768 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 710127000769 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 710127000770 substrate binding site; other site 710127000771 dimer interface; other site 710127000772 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 710127000773 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710127000774 Walker A/P-loop; other site 710127000775 ATP binding site [chemical binding]; other site 710127000776 Q-loop/lid; other site 710127000777 ABC transporter signature motif; other site 710127000778 Walker B; other site 710127000779 D-loop; other site 710127000780 H-loop/switch region; other site 710127000781 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 710127000782 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 710127000783 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 710127000784 Class I aldolases; Region: Aldolase_Class_I; cl17187 710127000785 catalytic residue [active] 710127000786 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 710127000787 MULE transposase domain; Region: MULE; pfam10551 710127000788 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 710127000789 Potential MGA_1088/89 ABC-type transport system ATPase component gene region; MGRL294 710127000790 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 710127000791 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 710127000792 Walker A/P-loop; other site 710127000793 ATP binding site [chemical binding]; other site 710127000794 Q-loop/lid; other site 710127000795 ABC transporter signature motif; other site 710127000796 Walker B; other site 710127000797 D-loop; other site 710127000798 H-loop/switch region; other site 710127000799 FtsX-like permease family; Region: FtsX; pfam02687 710127000800 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 710127000801 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 710127000802 Catalytic site [active] 710127000803 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 710127000804 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 710127000805 asparagine synthetase A; Reviewed; Region: PRK06462 710127000806 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 710127000807 active site 710127000808 dimer interface [polypeptide binding]; other site 710127000809 motif 2; other site 710127000810 motif 3; other site 710127000811 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 710127000812 metal binding site [ion binding]; metal-binding site 710127000813 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 710127000814 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710127000815 S-adenosylmethionine binding site [chemical binding]; other site 710127000816 RmuC family; Region: RmuC; pfam02646 710127000817 Potential MGA_1108/9 predicted ISMHp1-like transposase gene region; MGA_t10; MGRL304 710127000818 Transposase [DNA replication, recombination, and repair]; Region: COG5421 710127000819 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 710127000820 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 710127000821 Potential MGA_1113/2 gene region; MGRL307 710127000822 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 710127000823 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 710127000824 active site 710127000825 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 710127000826 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710127000827 active site 710127000828 motif I; other site 710127000829 motif II; other site 710127000830 Potential MGA_1117/9 cytadherence-related molecule (crmB)-like protein gene region; MGRL310 710127000831 adhesin P1; Region: termin_org_P1; TIGR03839 710127000832 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 710127000833 inorganic pyrophosphatase; Provisional; Region: PRK02230 710127000834 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 710127000835 dimer interface [polypeptide binding]; other site 710127000836 substrate binding site [chemical binding]; other site 710127000837 metal binding sites [ion binding]; metal-binding site 710127000838 Protein of unknown function DUF45; Region: DUF45; pfam01863 710127000839 FeS assembly ATPase SufC; Region: sufC; TIGR01978 710127000840 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 710127000841 Walker A/P-loop; other site 710127000842 ATP binding site [chemical binding]; other site 710127000843 Q-loop/lid; other site 710127000844 ABC transporter signature motif; other site 710127000845 Walker B; other site 710127000846 D-loop; other site 710127000847 H-loop/switch region; other site 710127000848 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 710127000849 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 710127000850 Aminotransferase class-V; Region: Aminotran_5; pfam00266 710127000851 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 710127000852 catalytic residue [active] 710127000853 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 710127000854 trimerization site [polypeptide binding]; other site 710127000855 active site 710127000856 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 710127000857 FeS assembly protein SufB; Region: sufB; TIGR01980 710127000858 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 710127000859 HSP70 interaction site [polypeptide binding]; other site 710127000860 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 710127000861 HSP70 interaction site [polypeptide binding]; other site 710127000862 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 710127000863 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 710127000864 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 710127000865 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 710127000866 HSP70 interaction site [polypeptide binding]; other site 710127000867 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 710127000868 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 710127000869 Walker A/P-loop; other site 710127000870 ATP binding site [chemical binding]; other site 710127000871 Q-loop/lid; other site 710127000872 ABC transporter signature motif; other site 710127000873 Walker B; other site 710127000874 D-loop; other site 710127000875 H-loop/switch region; other site 710127000876 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 710127000877 OsmC-like protein; Region: OsmC; cl00767 710127000878 signal recognition particle protein; Provisional; Region: PRK10867 710127000879 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 710127000880 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 710127000881 P loop; other site 710127000882 GTP binding site [chemical binding]; other site 710127000883 Signal peptide binding domain; Region: SRP_SPB; pfam02978 710127000884 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 710127000885 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 710127000886 active site 710127000887 HIGH motif; other site 710127000888 dimer interface [polypeptide binding]; other site 710127000889 KMSKS motif; other site 710127000890 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 710127000891 RNA binding surface [nucleotide binding]; other site 710127000892 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 710127000893 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 710127000894 dimer interface [polypeptide binding]; other site 710127000895 active site 710127000896 glycine-pyridoxal phosphate binding site [chemical binding]; other site 710127000897 folate binding site [chemical binding]; other site 710127000898 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 710127000899 active site 710127000900 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 710127000901 23S rRNA interface [nucleotide binding]; other site 710127000902 L3 interface [polypeptide binding]; other site 710127000903 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 710127000904 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 710127000905 GcpE protein; Region: GcpE; pfam04551 710127000906 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 710127000907 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 710127000908 active site 710127000909 Putative peptidase (DUF31); Region: DUF31; pfam01732 710127000910 Peptidase S7, Flavivirus NS3 serine protease; Region: Peptidase_S7; pfam00949 710127000911 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 710127000912 ATP synthase subunit C; Region: ATP-synt_C; cl00466 710127000913 F0F1 ATP synthase subunit B; Validated; Region: PRK06231 710127000914 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 710127000915 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 710127000916 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 710127000917 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 710127000918 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 710127000919 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 710127000920 beta subunit interaction interface [polypeptide binding]; other site 710127000921 Walker A motif; other site 710127000922 ATP binding site [chemical binding]; other site 710127000923 Walker B motif; other site 710127000924 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 710127000925 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 710127000926 core domain interface [polypeptide binding]; other site 710127000927 delta subunit interface [polypeptide binding]; other site 710127000928 epsilon subunit interface [polypeptide binding]; other site 710127000929 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 710127000930 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 710127000931 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 710127000932 alpha subunit interaction interface [polypeptide binding]; other site 710127000933 Walker A motif; other site 710127000934 ATP binding site [chemical binding]; other site 710127000935 Walker B motif; other site 710127000936 inhibitor binding site; inhibition site 710127000937 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 710127000938 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00539 710127000939 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 710127000940 gamma subunit interface [polypeptide binding]; other site 710127000941 epsilon subunit interface [polypeptide binding]; other site 710127000942 LBP interface [polypeptide binding]; other site 710127000943 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 710127000944 EDD domain protein, DegV family; Region: DegV; TIGR00762 710127000945 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 710127000946 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 710127000947 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 710127000948 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 710127000949 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 710127000950 Phosphoglycerate kinase; Region: PGK; pfam00162 710127000951 substrate binding site [chemical binding]; other site 710127000952 hinge regions; other site 710127000953 ADP binding site [chemical binding]; other site 710127000954 catalytic site [active] 710127000955 Amino acid permease; Region: AA_permease_2; pfam13520 710127000956 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 710127000957 S-adenosylmethionine binding site [chemical binding]; other site 710127000958 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 710127000959 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 710127000960 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 710127000961 active site 710127000962 HIGH motif; other site 710127000963 nucleotide binding site [chemical binding]; other site 710127000964 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 710127000965 active site 710127000966 KMSKS motif; other site 710127000967 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 710127000968 tRNA binding surface [nucleotide binding]; other site 710127000969 anticodon binding site; other site 710127000970 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 710127000971 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 710127000972 Protein of unknown function (DUF1664); Region: DUF1664; pfam07889 710127000973 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 710127000974 V-type ATP synthase subunit I; Validated; Region: PRK05771 710127000975 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 710127000976 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 710127000977 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 710127000978 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 710127000979 Amidinotransferase; Region: Amidinotransf; cl12043 710127000980 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 710127000981 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 710127000982 phosphodiesterase; Provisional; Region: PRK12704 710127000983 phosphodiesterase; Provisional; Region: PRK12704 710127000984 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710127000985 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 710127000986 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 710127000987 nucleophilic elbow; other site 710127000988 catalytic triad; other site 710127000989 Serine hydrolase (FSH1); Region: FSH1; pfam03959 710127000990 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 710127000991 HSP70 interaction site [polypeptide binding]; other site 710127000992 EAGR box; Region: EAGR_box; TIGR03834 710127000993 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 710127000994 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 710127000995 dimer interface [polypeptide binding]; other site 710127000996 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 710127000997 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 710127000998 dimer interface [polypeptide binding]; other site 710127000999 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 710127001000 Potential MGA_1233/34/37 VlhA.5.01 variable lipoprotein family protein gene region; MGRL378 710127001001 Cobalamin biosynthesis protein CobN and related Mg-chelatases [Coenzyme metabolism]; Region: CobN; COG1429 710127001002 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001003 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001004 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001005 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001006 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001007 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001008 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001009 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001010 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001011 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001012 Potential vlhA.5.10 variably expressed lipoprotein and hemagglutinin (VlhA) family protein gene region; MGRL387 710127001013 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001014 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001015 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001016 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001017 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 710127001018 active site 710127001019 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001020 beta-phosphoglucomutase; Region: bPGM; TIGR01990 710127001021 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 710127001022 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 710127001023 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 710127001024 Potential MGA_1350 hypothetical protein gene region; MGRL395 710127001025 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 710127001026 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 710127001027 TPP-binding site; other site 710127001028 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 710127001029 PYR/PP interface [polypeptide binding]; other site 710127001030 dimer interface [polypeptide binding]; other site 710127001031 TPP binding site [chemical binding]; other site 710127001032 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 710127001033 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 710127001034 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 710127001035 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 710127001036 GIY-YIG motif/motif A; other site 710127001037 active site 710127001038 catalytic site [active] 710127001039 putative DNA binding site [nucleotide binding]; other site 710127001040 metal binding site [ion binding]; metal-binding site 710127001041 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 710127001042 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 710127001043 translation initiation factor IF-3; Region: infC; TIGR00168 710127001044 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 710127001045 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 710127001046 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 710127001047 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 710127001048 23S rRNA binding site [nucleotide binding]; other site 710127001049 L21 binding site [polypeptide binding]; other site 710127001050 L13 binding site [polypeptide binding]; other site 710127001051 dUTPase; Region: dUTPase_2; pfam08761 710127001052 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 710127001053 active site 710127001054 homodimer interface [polypeptide binding]; other site 710127001055 metal binding site [ion binding]; metal-binding site 710127001056 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 710127001057 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 710127001058 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 710127001059 dimer interface [polypeptide binding]; other site 710127001060 motif 1; other site 710127001061 active site 710127001062 motif 2; other site 710127001063 motif 3; other site 710127001064 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 710127001065 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 710127001066 putative tRNA-binding site [nucleotide binding]; other site 710127001067 B3/4 domain; Region: B3_4; pfam03483 710127001068 tRNA synthetase B5 domain; Region: B5; smart00874 710127001069 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 710127001070 dimer interface [polypeptide binding]; other site 710127001071 motif 1; other site 710127001072 motif 3; other site 710127001073 motif 2; other site 710127001074 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 710127001075 active site 710127001076 P-loop; other site 710127001077 phosphorylation site [posttranslational modification] 710127001078 Potential MGA_1284/5 ABC transporter ATP-binding protein gene region; MGRL408 710127001079 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 710127001080 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 710127001081 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 710127001082 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710127001083 Q-loop/lid; other site 710127001084 ABC transporter signature motif; other site 710127001085 Walker B; other site 710127001086 D-loop; other site 710127001087 H-loop/switch region; other site 710127001088 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 710127001089 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 710127001090 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710127001091 Walker A/P-loop; other site 710127001092 ATP binding site [chemical binding]; other site 710127001093 Q-loop/lid; other site 710127001094 ABC transporter signature motif; other site 710127001095 Walker B; other site 710127001096 D-loop; other site 710127001097 H-loop/switch region; other site 710127001098 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 710127001099 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 710127001100 Protein of unknown function (DUF464); Region: DUF464; pfam04327 710127001101 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 710127001102 endonuclease IV; Provisional; Region: PRK01060 710127001103 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 710127001104 AP (apurinic/apyrimidinic) site pocket; other site 710127001105 DNA interaction; other site 710127001106 Metal-binding active site; metal-binding site 710127001107 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 710127001108 metal binding site 2 [ion binding]; metal-binding site 710127001109 putative DNA binding helix; other site 710127001110 metal binding site 1 [ion binding]; metal-binding site 710127001111 Protein of unknown function (DUF3196); Region: DUF3196; pfam11428 710127001112 trigger factor; Region: tig; TIGR00115 710127001113 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 710127001114 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 710127001115 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 710127001116 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710127001117 Walker A motif; other site 710127001118 ATP binding site [chemical binding]; other site 710127001119 Walker B motif; other site 710127001120 arginine finger; other site 710127001121 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 710127001122 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 710127001123 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 710127001124 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 710127001125 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 710127001126 Walker A/P-loop; other site 710127001127 ATP binding site [chemical binding]; other site 710127001128 Q-loop/lid; other site 710127001129 ABC transporter signature motif; other site 710127001130 Walker B; other site 710127001131 D-loop; other site 710127001132 H-loop/switch region; other site 710127001133 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 710127001134 putative active site [active] 710127001135 putative catalytic site [active] 710127001136 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 710127001137 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 710127001138 putative active site [active] 710127001139 metal binding site [ion binding]; metal-binding site 710127001140 homodimer binding site [polypeptide binding]; other site 710127001141 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 710127001142 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 710127001143 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 710127001144 Part of AAA domain; Region: AAA_19; pfam13245 710127001145 Family description; Region: UvrD_C_2; pfam13538 710127001146 RDD family; Region: RDD; pfam06271 710127001147 NifU-like domain; Region: NifU; cl00484 710127001148 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 710127001149 Uncharacterized conserved protein [Function unknown]; Region: COG0327 710127001150 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 710127001151 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 710127001152 Family of unknown function (DUF633); Region: DUF633; pfam04816 710127001153 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 710127001154 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 710127001155 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 710127001156 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 710127001157 DNA binding residues [nucleotide binding] 710127001158 DNA primase (bacterial type) [DNA replication, recombination, and repair]; Region: DnaG; COG0358 710127001159 CHC2 zinc finger; Region: zf-CHC2; cl17510 710127001160 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 710127001161 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 710127001162 active site 710127001163 metal binding site [ion binding]; metal-binding site 710127001164 interdomain interaction site; other site 710127001165 glycyl-tRNA synthetase; Provisional; Region: PRK04173 710127001166 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 710127001167 motif 1; other site 710127001168 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 710127001169 active site 710127001170 motif 2; other site 710127001171 motif 3; other site 710127001172 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 710127001173 anticodon binding site; other site 710127001174 Recombination protein O N terminal; Region: RecO_N; pfam11967 710127001175 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 710127001176 GTPase [General function prediction only]; Region: Era; COG1159 710127001177 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 710127001178 G1 box; other site 710127001179 GTP/Mg2+ binding site [chemical binding]; other site 710127001180 Switch I region; other site 710127001181 G2 box; other site 710127001182 Switch II region; other site 710127001183 G3 box; other site 710127001184 G4 box; other site 710127001185 G5 box; other site 710127001186 KH domain; Region: KH_2; pfam07650 710127001187 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 710127001188 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 710127001189 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39E; cd02424 710127001190 putative active site [active] 710127001191 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 710127001192 Walker A/P-loop; other site 710127001193 ATP binding site [chemical binding]; other site 710127001194 Q-loop/lid; other site 710127001195 ABC transporter signature motif; other site 710127001196 Walker B; other site 710127001197 D-loop; other site 710127001198 H-loop/switch region; other site 710127001199 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 710127001200 nucleotide binding site [chemical binding]; other site 710127001201 SulA interaction site; other site 710127001202 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 710127001203 MraW methylase family; Region: Methyltransf_5; cl17771 710127001204 cell division protein MraZ; Reviewed; Region: PRK00326 710127001205 MraZ protein; Region: MraZ; pfam02381 710127001206 MraZ protein; Region: MraZ; pfam02381 710127001207 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 710127001208 segregation and condensation protein A/unknown domain fusion protein; Provisional; Region: scpA; PRK00478 710127001209 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 710127001210 folate binding site [chemical binding]; other site 710127001211 NADP+ binding site [chemical binding]; other site 710127001212 ScpA/B protein; Region: ScpA_ScpB; cl00598 710127001213 Selenoprotein S (SelS); Region: Selenoprotein_S; pfam06936 710127001214 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 710127001215 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 710127001216 putative acyl-acceptor binding pocket; other site 710127001217 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 710127001218 cell division protein GpsB; Provisional; Region: PRK14127 710127001219 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 710127001220 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 710127001221 RNA/DNA hybrid binding site [nucleotide binding]; other site 710127001222 active site 710127001223 hypothetical protein; Provisional; Region: PRK06148 710127001224 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 710127001225 AAA ATPase containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: MDN1; COG5271 710127001226 Potential MGA_0050/1318/0049/1317 hypothetical membrane protein gene region; MGRL456 710127001227 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 710127001228 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 710127001229 putative nicotinate-nucleotide adenylyltransferase; Validated; Region: nadD; PRK07152 710127001230 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 710127001231 active site 710127001232 (T/H)XGH motif; other site 710127001233 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 710127001234 Zn2+ binding site [ion binding]; other site 710127001235 Mg2+ binding site [ion binding]; other site 710127001236 ribosome biogenesis GTPase YqeH; Region: GTPase_YqeH; TIGR03597 710127001237 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 710127001238 GTP/Mg2+ binding site [chemical binding]; other site 710127001239 G4 box; other site 710127001240 G5 box; other site 710127001241 G1 box; other site 710127001242 Switch I region; other site 710127001243 G2 box; other site 710127001244 G3 box; other site 710127001245 Switch II region; other site 710127001246 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 710127001247 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 710127001248 CAP-like domain; other site 710127001249 active site 710127001250 primary dimer interface [polypeptide binding]; other site 710127001251 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 710127001252 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 710127001253 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 710127001254 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710127001255 ATP binding site [chemical binding]; other site 710127001256 Mg2+ binding site [ion binding]; other site 710127001257 G-X-G motif; other site 710127001258 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 710127001259 anchoring element; other site 710127001260 dimer interface [polypeptide binding]; other site 710127001261 ATP binding site [chemical binding]; other site 710127001262 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 710127001263 active site 710127001264 putative metal-binding site [ion binding]; other site 710127001265 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 710127001266 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 710127001267 IHF - DNA interface [nucleotide binding]; other site 710127001268 IHF dimer interface [polypeptide binding]; other site 710127001269 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001270 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001271 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001272 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001273 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001274 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001275 Potential MGA_0073 predicted transposase gene region; MGA_t12; MGRL471 710127001276 Transposase, Mutator family; Region: Transposase_mut; pfam00872 710127001277 MULE transposase domain; Region: MULE; pfam10551 710127001278 GA module; Region: GA; pfam01468 710127001279 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001280 Potential MGA_0080/79 VlhA1.08 variable lipoprotein family protein gene region; MGRL474 710127001281 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001282 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 710127001283 TrkA-N domain; Region: TrkA_N; pfam02254 710127001284 TrkA-C domain; Region: TrkA_C; pfam02080 710127001285 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 710127001286 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 710127001287 HIGH motif; other site 710127001288 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 710127001289 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 710127001290 active site 710127001291 KMSKS motif; other site 710127001292 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 710127001293 tRNA binding surface [nucleotide binding]; other site 710127001294 anticodon binding site; other site 710127001295 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 710127001296 substrate binding site [chemical binding]; other site 710127001297 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 710127001298 substrate binding site [chemical binding]; other site 710127001299 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 710127001300 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 710127001301 active site 710127001302 catalytic tetrad [active] 710127001303 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 710127001304 trimer interface [polypeptide binding]; other site 710127001305 active site 710127001306 G bulge; other site 710127001307 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 710127001308 trimer interface [polypeptide binding]; other site 710127001309 active site 710127001310 G bulge; other site 710127001311 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 710127001312 SmpB-tmRNA interface; other site 710127001313 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 710127001314 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 710127001315 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 710127001316 active site 710127001317 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 710127001318 Arginine deiminase [Amino acid transport and metabolism]; Region: ArcA; COG2235 710127001319 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 710127001320 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 710127001321 Sugar specificity; other site 710127001322 Pyrimidine base specificity; other site 710127001323 ATP-binding site [chemical binding]; other site 710127001324 GTPase CgtA; Reviewed; Region: obgE; PRK12297 710127001325 GTP1/OBG; Region: GTP1_OBG; pfam01018 710127001326 Obg GTPase; Region: Obg; cd01898 710127001327 G1 box; other site 710127001328 GTP/Mg2+ binding site [chemical binding]; other site 710127001329 Switch I region; other site 710127001330 G2 box; other site 710127001331 G3 box; other site 710127001332 Switch II region; other site 710127001333 G4 box; other site 710127001334 G5 box; other site 710127001335 Obg family GTPase CgtA, C-terminal extension; Region: Obg_CgtA_exten; TIGR03595 710127001336 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 710127001337 multifunctional aminopeptidase A; Provisional; Region: PRK00913 710127001338 interface (dimer of trimers) [polypeptide binding]; other site 710127001339 Substrate-binding/catalytic site; other site 710127001340 Zn-binding sites [ion binding]; other site 710127001341 C4-dicarboxylate transporter/malic acid transport protein; Region: C4dic_mal_tran; pfam03595 710127001342 gating phenylalanine in ion channel; other site 710127001343 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001344 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 710127001345 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001346 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 710127001347 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 710127001348 ribonuclease R; Region: RNase_R; TIGR02063 710127001349 RNB domain; Region: RNB; pfam00773 710127001350 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 710127001351 RNA binding site [nucleotide binding]; other site 710127001352 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 710127001353 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 710127001354 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710127001355 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710127001356 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 710127001357 DNA-binding site [nucleotide binding]; DNA binding site 710127001358 S-adenosylmethionine synthetase; Validated; Region: PRK05250 710127001359 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 710127001360 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 710127001361 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 710127001362 tRNA threonylcarbamoyl adenosine modification protein YgjD; Region: T6A_YgjD; TIGR03723 710127001363 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 710127001364 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 710127001365 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 710127001366 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710127001367 dimer interface [polypeptide binding]; other site 710127001368 conserved gate region; other site 710127001369 putative PBP binding loops; other site 710127001370 ABC-ATPase subunit interface; other site 710127001371 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710127001372 dimer interface [polypeptide binding]; other site 710127001373 conserved gate region; other site 710127001374 putative PBP binding loops; other site 710127001375 ABC-ATPase subunit interface; other site 710127001376 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 710127001377 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710127001378 Walker A/P-loop; other site 710127001379 ATP binding site [chemical binding]; other site 710127001380 Q-loop/lid; other site 710127001381 AAA domain; Region: AAA_21; pfam13304 710127001382 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 710127001383 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710127001384 ABC transporter signature motif; other site 710127001385 Walker B; other site 710127001386 D-loop; other site 710127001387 H-loop/switch region; other site 710127001388 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl17245 710127001389 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 710127001390 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 710127001391 Zn2+ binding site [ion binding]; other site 710127001392 Mg2+ binding site [ion binding]; other site 710127001393 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 710127001394 recombinase A; Provisional; Region: recA; PRK09354 710127001395 hexamer interface [polypeptide binding]; other site 710127001396 Walker A motif; other site 710127001397 ATP binding site [chemical binding]; other site 710127001398 Walker B motif; other site 710127001399 Potential MGA_0145 predicted transposase gene region; MGA_t13; MGRL518 710127001400 Transposase, Mutator family; Region: Transposase_mut; pfam00872 710127001401 MULE transposase domain; Region: MULE; pfam10551 710127001402 Potential MGA_0148/7 predicted transposase gene region; MGA_t14; MGRL519 710127001403 Transposase, Mutator family; Region: Transposase_mut; pfam00872 710127001404 MULE transposase domain; Region: MULE; pfam10551 710127001405 methionine sulfoxide reductase B; Provisional; Region: PRK00222 710127001406 SelR domain; Region: SelR; pfam01641 710127001407 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 710127001408 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 710127001409 ring oligomerisation interface [polypeptide binding]; other site 710127001410 ATP/Mg binding site [chemical binding]; other site 710127001411 stacking interactions; other site 710127001412 hinge regions; other site 710127001413 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 710127001414 oligomerisation interface [polypeptide binding]; other site 710127001415 mobile loop; other site 710127001416 roof hairpin; other site 710127001417 pyruvate kinase; Provisional; Region: PRK05826 710127001418 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 710127001419 domain interfaces; other site 710127001420 active site 710127001421 6-phosphofructokinase; Provisional; Region: PRK03202 710127001422 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 710127001423 active site 710127001424 ADP/pyrophosphate binding site [chemical binding]; other site 710127001425 dimerization interface [polypeptide binding]; other site 710127001426 allosteric effector site; other site 710127001427 fructose-1,6-bisphosphate binding site; other site 710127001428 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 710127001429 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 710127001430 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 710127001431 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 710127001432 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 710127001433 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710127001434 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 710127001435 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 710127001436 E3 interaction surface; other site 710127001437 lipoyl attachment site [posttranslational modification]; other site 710127001438 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 710127001439 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 710127001440 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 710127001441 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 710127001442 alpha subunit interface [polypeptide binding]; other site 710127001443 TPP binding site [chemical binding]; other site 710127001444 heterodimer interface [polypeptide binding]; other site 710127001445 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 710127001446 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 710127001447 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 710127001448 tetramer interface [polypeptide binding]; other site 710127001449 TPP-binding site [chemical binding]; other site 710127001450 heterodimer interface [polypeptide binding]; other site 710127001451 phosphorylation loop region [posttranslational modification] 710127001452 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 710127001453 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 710127001454 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 710127001455 propionate/acetate kinase; Provisional; Region: PRK12379 710127001456 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 710127001457 nucleotide binding site [chemical binding]; other site 710127001458 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 710127001459 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 710127001460 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 710127001461 Domain of unknown function DUF21; Region: DUF21; pfam01595 710127001462 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 710127001463 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 710127001464 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 710127001465 Substrate-binding site [chemical binding]; other site 710127001466 Substrate specificity [chemical binding]; other site 710127001467 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 710127001468 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 710127001469 Substrate-binding site [chemical binding]; other site 710127001470 Substrate specificity [chemical binding]; other site 710127001471 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710127001472 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 710127001473 Walker A motif; other site 710127001474 ATP binding site [chemical binding]; other site 710127001475 Walker B motif; other site 710127001476 arginine finger; other site 710127001477 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710127001478 AAA domain; Region: AAA_22; pfam13401 710127001479 Walker A motif; other site 710127001480 ATP binding site [chemical binding]; other site 710127001481 Walker B motif; other site 710127001482 arginine finger; other site 710127001483 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 710127001484 ribonuclease III; Reviewed; Region: rnc; PRK00102 710127001485 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 710127001486 dimerization interface [polypeptide binding]; other site 710127001487 active site 710127001488 metal binding site [ion binding]; metal-binding site 710127001489 putative phosphate acyltransferase; Provisional; Region: PRK05331 710127001490 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 710127001491 DAK2 domain; Region: Dak2; pfam02734 710127001492 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 710127001493 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 710127001494 RNA binding surface [nucleotide binding]; other site 710127001495 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 710127001496 active site 710127001497 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 710127001498 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 710127001499 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 710127001500 DHH family; Region: DHH; pfam01368 710127001501 DHHA1 domain; Region: DHHA1; pfam02272 710127001502 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 710127001503 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 710127001504 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 710127001505 Ligand Binding Site [chemical binding]; other site 710127001506 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 710127001507 EAGR box; Region: EAGR_box; TIGR03834 710127001508 EAGR box; Region: EAGR_box; TIGR03834 710127001509 EAGR box; Region: EAGR_box; TIGR03834 710127001510 EAGR box; Region: EAGR_box; TIGR03834 710127001511 EAGR box; Region: EAGR_box; TIGR03834 710127001512 EAGR box; Region: EAGR_box; TIGR03834 710127001513 EAGR box; Region: EAGR_box; TIGR03834 710127001514 EAGR box; Region: EAGR_box; TIGR03834 710127001515 EAGR box; Region: EAGR_box; TIGR03834 710127001516 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 710127001517 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 710127001518 ATP binding site [chemical binding]; other site 710127001519 putative Mg++ binding site [ion binding]; other site 710127001520 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710127001521 nucleotide binding region [chemical binding]; other site 710127001522 ATP-binding site [chemical binding]; other site 710127001523 enolase; Provisional; Region: eno; PRK00077 710127001524 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 710127001525 dimer interface [polypeptide binding]; other site 710127001526 metal binding site [ion binding]; metal-binding site 710127001527 substrate binding pocket [chemical binding]; other site 710127001528 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 710127001529 HIT family signature motif; other site 710127001530 catalytic residue [active] 710127001531 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 710127001532 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 710127001533 translation elongation factor P; Region: efp; TIGR00038 710127001534 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 710127001535 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 710127001536 RNA binding site [nucleotide binding]; other site 710127001537 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 710127001538 RNA binding site [nucleotide binding]; other site 710127001539 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 710127001540 Walker A/P-loop; other site 710127001541 ATP binding site [chemical binding]; other site 710127001542 Q-loop/lid; other site 710127001543 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 710127001544 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 710127001545 ABC transporter signature motif; other site 710127001546 Walker B; other site 710127001547 D-loop; other site 710127001548 H-loop/switch region; other site 710127001549 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 710127001550 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 710127001551 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 710127001552 Walker A/P-loop; other site 710127001553 ATP binding site [chemical binding]; other site 710127001554 Q-loop/lid; other site 710127001555 ABC transporter signature motif; other site 710127001556 Walker B; other site 710127001557 D-loop; other site 710127001558 H-loop/switch region; other site 710127001559 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 710127001560 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 710127001561 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710127001562 dimer interface [polypeptide binding]; other site 710127001563 conserved gate region; other site 710127001564 putative PBP binding loops; other site 710127001565 ABC-ATPase subunit interface; other site 710127001566 Potential MGA_0224/3 ABC-type dipeptide/oligopeptide/nickel transport system permease protein (DppB/OppB) gene region; MGRL562 710127001567 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 710127001568 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710127001569 ABC-ATPase subunit interface; other site 710127001570 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 710127001571 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 710127001572 AAA domain; Region: AAA_21; pfam13304 710127001573 Walker A/P-loop; other site 710127001574 ATP binding site [chemical binding]; other site 710127001575 Q-loop/lid; other site 710127001576 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 710127001577 ABC transporter signature motif; other site 710127001578 Walker B; other site 710127001579 D-loop; other site 710127001580 H-loop/switch region; other site 710127001581 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 710127001582 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 710127001583 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 710127001584 Walker A/P-loop; other site 710127001585 ATP binding site [chemical binding]; other site 710127001586 Q-loop/lid; other site 710127001587 ABC transporter signature motif; other site 710127001588 Walker B; other site 710127001589 D-loop; other site 710127001590 H-loop/switch region; other site 710127001591 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 710127001592 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 710127001593 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710127001594 dimer interface [polypeptide binding]; other site 710127001595 conserved gate region; other site 710127001596 putative PBP binding loops; other site 710127001597 ABC-ATPase subunit interface; other site 710127001598 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 710127001599 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 710127001600 dimer interface [polypeptide binding]; other site 710127001601 conserved gate region; other site 710127001602 putative PBP binding loops; other site 710127001603 ABC-ATPase subunit interface; other site 710127001604 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 710127001605 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 710127001606 rRNA interaction site [nucleotide binding]; other site 710127001607 S8 interaction site; other site 710127001608 azoreductase; Reviewed; Region: PRK01355 710127001609 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 710127001610 recombination factor protein RarA; Reviewed; Region: PRK13342 710127001611 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710127001612 Walker A motif; other site 710127001613 ATP binding site [chemical binding]; other site 710127001614 Walker B motif; other site 710127001615 arginine finger; other site 710127001616 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 710127001617 Predicted methyltransferases [General function prediction only]; Region: COG0313 710127001618 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 710127001619 putative SAM binding site [chemical binding]; other site 710127001620 putative homodimer interface [polypeptide binding]; other site 710127001621 Potential MGA_0250 unique hypothetical protein gene region; product in strain R(low) clonal isolate (clone 2) lacks N-terminal 61 amino acids present in other M.gallisepticum isolates including high passage strain R(high); MGRL576 710127001622 OsmC-like protein; Region: OsmC; pfam02566 710127001623 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 710127001624 Potential MGA_0258/6 phase-variant protein A (pvpA) gene region; MGRL580 710127001625 elongation factor G; Reviewed; Region: PRK00007 710127001626 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 710127001627 G1 box; other site 710127001628 putative GEF interaction site [polypeptide binding]; other site 710127001629 GTP/Mg2+ binding site [chemical binding]; other site 710127001630 Switch I region; other site 710127001631 G2 box; other site 710127001632 G3 box; other site 710127001633 Switch II region; other site 710127001634 G4 box; other site 710127001635 G5 box; other site 710127001636 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 710127001637 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 710127001638 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 710127001639 30S ribosomal protein S7; Validated; Region: PRK05302 710127001640 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 710127001641 S17 interaction site [polypeptide binding]; other site 710127001642 S8 interaction site; other site 710127001643 16S rRNA interaction site [nucleotide binding]; other site 710127001644 streptomycin interaction site [chemical binding]; other site 710127001645 23S rRNA interaction site [nucleotide binding]; other site 710127001646 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 710127001647 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 710127001648 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 710127001649 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 710127001650 RNA binding surface [nucleotide binding]; other site 710127001651 Putative peptidase (DUF31); Region: DUF31; pfam01732 710127001652 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 710127001653 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 710127001654 nucleotide binding site [chemical binding]; other site 710127001655 Predicted integral membrane protein [Function unknown]; Region: COG0392 710127001656 Ion channel; Region: Ion_trans_2; pfam07885 710127001657 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 710127001658 Amino acid permease; Region: AA_permease_2; pfam13520 710127001659 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 710127001660 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK00561 710127001661 ATP-NAD kinase; Region: NAD_kinase; pfam01513 710127001662 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 710127001663 ArsC family; Region: ArsC; pfam03960 710127001664 putative catalytic residues [active] 710127001665 thiol/disulfide switch; other site 710127001666 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 710127001667 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 710127001668 active site 710127001669 HIGH motif; other site 710127001670 dimer interface [polypeptide binding]; other site 710127001671 KMSKS motif; other site 710127001672 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710127001673 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 710127001674 active site 710127001675 motif I; other site 710127001676 motif II; other site 710127001677 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 710127001678 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 710127001679 active site 710127001680 motif I; other site 710127001681 motif II; other site 710127001682 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 710127001683 motif II; other site 710127001684 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 710127001685 cytadherence high molecular weight protein 1 N-terminal region; Region: termin_org_HMW1; TIGR03836 710127001686 EAGR box; Region: EAGR_box; TIGR03834 710127001687 EAGR box; Region: EAGR_box; TIGR03834 710127001688 EAGR box; Region: EAGR_box; TIGR03834 710127001689 EAGR box; Region: EAGR_box; TIGR03834 710127001690 EAGR box; Region: EAGR_box; TIGR03834 710127001691 EAGR box; Region: EAGR_box; TIGR03834 710127001692 EAGR box; Region: EAGR_box; TIGR03834 710127001693 GTP-binding protein LepA; Provisional; Region: PRK05433 710127001694 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 710127001695 G1 box; other site 710127001696 putative GEF interaction site [polypeptide binding]; other site 710127001697 GTP/Mg2+ binding site [chemical binding]; other site 710127001698 Switch I region; other site 710127001699 G2 box; other site 710127001700 G3 box; other site 710127001701 Switch II region; other site 710127001702 G4 box; other site 710127001703 G5 box; other site 710127001704 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 710127001705 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 710127001706 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 710127001707 Protein of unknown function (DUF1600); Region: DUF1600; pfam07667 710127001708 Protein of unknown function (DUF1600); Region: DUF1600; pfam07667 710127001709 Protein of unknown function (DUF1600); Region: DUF1600; pfam07667 710127001710 Protein of unknown function (DUF3713); Region: DUF3713; pfam12506 710127001711 Protein of unknown function (DUF3713); Region: DUF3713; pfam12506 710127001712 hypothetical protein; Provisional; Region: PRK09609 710127001713 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 710127001714 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 710127001715 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 710127001716 Asp-box motif; other site 710127001717 catalytic site [active] 710127001718 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 710127001719 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 710127001720 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 710127001721 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 710127001722 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 710127001723 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 710127001724 active site 710127001725 HIGH motif; other site 710127001726 nucleotide binding site [chemical binding]; other site 710127001727 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 710127001728 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 710127001729 active site 710127001730 KMSKS motif; other site 710127001731 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 710127001732 tRNA binding surface [nucleotide binding]; other site 710127001733 anticodon binding site; other site 710127001734 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 710127001735 G1 box; other site 710127001736 GTP/Mg2+ binding site [chemical binding]; other site 710127001737 Switch I region; other site 710127001738 G2 box; other site 710127001739 G3 box; other site 710127001740 Switch II region; other site 710127001741 G4 box; other site 710127001742 G5 box; other site 710127001743 hypothetical protein; Provisional; Region: PRK00523 710127001744 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 710127001745 TPP-binding site [chemical binding]; other site 710127001746 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 710127001747 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 710127001748 active site 710127001749 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 710127001750 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 710127001751 active site 710127001752 DNA binding site [nucleotide binding] 710127001753 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 710127001754 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 710127001755 putative active site [active] 710127001756 putative metal binding site [ion binding]; other site 710127001757 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 710127001758 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK00553 710127001759 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 710127001760 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 710127001761 active site 710127001762 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 710127001763 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 710127001764 dimerization interface 3.5A [polypeptide binding]; other site 710127001765 active site 710127001766 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 710127001767 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13631 710127001768 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 710127001769 Walker A/P-loop; other site 710127001770 ATP binding site [chemical binding]; other site 710127001771 Q-loop/lid; other site 710127001772 ABC transporter signature motif; other site 710127001773 Walker B; other site 710127001774 D-loop; other site 710127001775 H-loop/switch region; other site 710127001776 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13632 710127001777 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 710127001778 Walker A/P-loop; other site 710127001779 ATP binding site [chemical binding]; other site 710127001780 Q-loop/lid; other site 710127001781 ABC transporter signature motif; other site 710127001782 Walker B; other site 710127001783 D-loop; other site 710127001784 H-loop/switch region; other site 710127001785 phosphoglyceromutase; Provisional; Region: PRK05434 710127001786 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 710127001787 triosephosphate isomerase; Provisional; Region: PRK14565 710127001788 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 710127001789 substrate binding site [chemical binding]; other site 710127001790 dimer interface [polypeptide binding]; other site 710127001791 catalytic triad [active] 710127001792 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 710127001793 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 710127001794 active site 710127001795 substrate binding site [chemical binding]; other site 710127001796 metal binding site [ion binding]; metal-binding site 710127001797 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 710127001798 active site 710127001799 catalytic motif [active] 710127001800 Zn binding site [ion binding]; other site 710127001801 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 710127001802 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 710127001803 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 710127001804 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 710127001805 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 710127001806 intersubunit interface [polypeptide binding]; other site 710127001807 active site 710127001808 catalytic residue [active] 710127001809 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 710127001810 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 710127001811 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 710127001812 TM-ABC transporter signature motif; other site 710127001813 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 710127001814 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 710127001815 TM-ABC transporter signature motif; other site 710127001816 Sds3-like; Region: Sds3; pfam08598 710127001817 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 710127001818 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 710127001819 Walker A/P-loop; other site 710127001820 ATP binding site [chemical binding]; other site 710127001821 Q-loop/lid; other site 710127001822 ABC transporter signature motif; other site 710127001823 Walker B; other site 710127001824 D-loop; other site 710127001825 H-loop/switch region; other site 710127001826 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 710127001827 Potential MGA_0376/7 VlhA.3.0.1 variable lipoprotein family protein gene region; MGRL642 710127001828 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001829 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001830 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001831 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001832 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001833 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001834 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001835 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001836 Mycoplasma haemagglutinin; Region: Myco_haema; pfam05692 710127001837 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 710127001838 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 710127001839 recombination protein RecR; Reviewed; Region: recR; PRK00076 710127001840 RecR protein; Region: RecR; pfam02132 710127001841 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 710127001842 putative active site [active] 710127001843 putative metal-binding site [ion binding]; other site 710127001844 tetramer interface [polypeptide binding]; other site 710127001845 hypothetical protein; Provisional; Region: PRK00587 710127001846 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05896 710127001847 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710127001848 Walker A motif; other site 710127001849 ATP binding site [chemical binding]; other site 710127001850 Walker B motif; other site 710127001851 arginine finger; other site 710127001852 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 710127001853 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710127001854 Walker A motif; other site 710127001855 ATP binding site [chemical binding]; other site 710127001856 Walker B motif; other site 710127001857 arginine finger; other site 710127001858 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 710127001859 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 710127001860 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 710127001861 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 710127001862 GatB domain; Region: GatB_Yqey; pfam02637 710127001863 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 710127001864 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 710127001865 aspartyl/glutamyl-tRNA amidotransferase subunit C-like protein; Provisional; Region: PRK12821 710127001866 hypothetical protein; Provisional; Region: PRK09609 710127001867 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721 710127001868 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 710127001869 ligand binding site [chemical binding]; other site 710127001870 active site 710127001871 UGI interface [polypeptide binding]; other site 710127001872 catalytic site [active] 710127001873 replicative DNA helicase; Region: DnaB; TIGR00665 710127001874 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 710127001875 Walker A motif; other site 710127001876 ATP binding site [chemical binding]; other site 710127001877 Walker B motif; other site 710127001878 DNA binding loops [nucleotide binding] 710127001879 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 710127001880 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 710127001881 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 710127001882 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 710127001883 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 710127001884 dimer interface [polypeptide binding]; other site 710127001885 ssDNA binding site [nucleotide binding]; other site 710127001886 tetramer (dimer of dimers) interface [polypeptide binding]; other site 710127001887 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 710127001888 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 710127001889 dimer interface [polypeptide binding]; other site 710127001890 active site 710127001891 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 710127001892 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 710127001893 active site 710127001894 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 710127001895 Mg296 protein; Region: Mg296; pfam09644 710127001896 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 710127001897 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 710127001898 active site 710127001899 motif I; other site 710127001900 motif II; other site 710127001901 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 710127001902 motif II; other site 710127001903 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 710127001904 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 710127001905 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 710127001906 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 710127001907 GTP/Mg2+ binding site [chemical binding]; other site 710127001908 G4 box; other site 710127001909 G5 box; other site 710127001910 G1 box; other site 710127001911 Switch I region; other site 710127001912 G2 box; other site 710127001913 G3 box; other site 710127001914 Switch II region; other site 710127001915 Uncharacterized conserved protein [Function unknown]; Region: COG1284 710127001916 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 710127001917 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 710127001918 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 710127001919 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 710127001920 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 710127001921 Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203 710127001922 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 710127001923 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 710127001924 alphaNTD homodimer interface [polypeptide binding]; other site 710127001925 alphaNTD - beta interaction site [polypeptide binding]; other site 710127001926 alphaNTD - beta' interaction site [polypeptide binding]; other site 710127001927 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 710127001928 30S ribosomal protein S11; Validated; Region: PRK05309 710127001929 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 710127001930 30S ribosomal protein S13; Region: bact_S13; TIGR03631 710127001931 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 710127001932 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 710127001933 rRNA binding site [nucleotide binding]; other site 710127001934 predicted 30S ribosome binding site; other site 710127001935 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 710127001936 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 710127001937 catalytic residues [active] 710127001938 DNA topoisomerase I; Validated; Region: PRK05582 710127001939 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 710127001940 active site 710127001941 interdomain interaction site; other site 710127001942 putative metal-binding site [ion binding]; other site 710127001943 nucleotide binding site [chemical binding]; other site 710127001944 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 710127001945 domain I; other site 710127001946 DNA binding groove [nucleotide binding] 710127001947 phosphate binding site [ion binding]; other site 710127001948 domain II; other site 710127001949 domain III; other site 710127001950 nucleotide binding site [chemical binding]; other site 710127001951 catalytic site [active] 710127001952 domain IV; other site 710127001953 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 710127001954 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 710127001955 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 710127001956 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 710127001957 substrate binding site [chemical binding]; other site 710127001958 hexamer interface [polypeptide binding]; other site 710127001959 metal binding site [ion binding]; metal-binding site 710127001960 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 710127001961 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 710127001962 active site 710127001963 dimer interface [polypeptide binding]; other site 710127001964 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 710127001965 dimer interface [polypeptide binding]; other site 710127001966 active site 710127001967 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 710127001968 RNA binding site [nucleotide binding]; other site 710127001969 ribosome small subunit-dependent GTPase A; Region: TIGR00157 710127001970 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 710127001971 GTPase/Zn-binding domain interface [polypeptide binding]; other site 710127001972 GTP/Mg2+ binding site [chemical binding]; other site 710127001973 G4 box; other site 710127001974 G1 box; other site 710127001975 Switch I region; other site 710127001976 G2 box; other site 710127001977 G3 box; other site 710127001978 Switch II region; other site 710127001979 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 710127001980 Catalytic domain of Protein Kinases; Region: PKc; cd00180 710127001981 active site 710127001982 ATP binding site [chemical binding]; other site 710127001983 substrate binding site [chemical binding]; other site 710127001984 activation loop (A-loop); other site 710127001985 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 710127001986 active site 710127001987 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 710127001988 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 710127001989 catalytic site [active] 710127001990 G-X2-G-X-G-K; other site 710127001991 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 710127001992 active site 710127001993 catalytic residues [active] 710127001994 metal binding site [ion binding]; metal-binding site 710127001995 Mycoplasma MFS transporter; Region: MFS_Mycoplasma; pfam07672 710127001996 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 710127001997 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 710127001998 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 710127001999 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 710127002000 16S rRNA (guanine(527)-N(7))-methyltransferase GidB; Region: gidB; TIGR00138 710127002001 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 710127002002 NusG family protein; Region: NusG_myco; TIGR01956 710127002003 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 710127002004 putative homodimer interface [polypeptide binding]; other site 710127002005 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 710127002006 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 710127002007 Transposase, Mutator family; Region: Transposase_mut; pfam00872 710127002008 MULE transposase domain; Region: MULE; pfam10551 710127002009 Protein of unknown function (DUF2714); Region: DUF2714; pfam10896 710127002010 Potential MGA_0485/7 conserved hypothetical gene region; MGRL710 710127002011 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 710127002012 F0F1 ATP synthase subunit alpha; Validated; Region: PRK07165 710127002013 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 710127002014 Walker A motif; other site 710127002015 ATP binding site [chemical binding]; other site 710127002016 Walker B motif; other site 710127002017 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 710127002018 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 710127002019 Walker A motif; other site 710127002020 ATP binding site [chemical binding]; other site 710127002021 Walker B motif; other site 710127002022 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 710127002023 Putative peptidase (DUF31); Region: DUF31; pfam01732 710127002024 Putative peptidase (DUF31); Region: DUF31; pfam01732 710127002025 DNA-directed RNA polymerase subunit delta; Reviewed; Region: PRK02363 710127002026 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 710127002027 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 710127002028 intersubunit interface [polypeptide binding]; other site 710127002029 active site 710127002030 zinc binding site [ion binding]; other site 710127002031 Na+ binding site [ion binding]; other site 710127002032 GTP-binding protein YchF; Reviewed; Region: PRK09601 710127002033 YchF GTPase; Region: YchF; cd01900 710127002034 G1 box; other site 710127002035 GTP/Mg2+ binding site [chemical binding]; other site 710127002036 Switch I region; other site 710127002037 G2 box; other site 710127002038 Switch II region; other site 710127002039 G3 box; other site 710127002040 G4 box; other site 710127002041 G5 box; other site 710127002042 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 710127002043 thymidine kinase; Provisional; Region: PRK04296 710127002044 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 710127002045 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 710127002046 23S rRNA interface [nucleotide binding]; other site 710127002047 L7/L12 interface [polypeptide binding]; other site 710127002048 putative thiostrepton binding site; other site 710127002049 L25 interface [polypeptide binding]; other site 710127002050 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 710127002051 mRNA/rRNA interface [nucleotide binding]; other site 710127002052 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 710127002053 putative active site [active] 710127002054 catalytic residue [active] 710127002055 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 710127002056 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 710127002057 Ligand Binding Site [chemical binding]; other site 710127002058 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 710127002059 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 710127002060 active site 710127002061 phosphorylation site [posttranslational modification] 710127002062 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 710127002063 active site 710127002064 P-loop; other site 710127002065 phosphorylation site [posttranslational modification] 710127002066 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 710127002067 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 710127002068 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 710127002069 Potential MGA_0518/7 Subtilisin-like serine protease gene region; MGRL727 710127002070 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 710127002071 active site 710127002072 catalytic residues [active] 710127002073 CRISPR/Cas system-associated protein Cas9; Region: Csn1; cd09643 710127002074 CRISPR-associated protein Cas9/Csn1, subtype II/NMEMI; Region: cas_Csn1; TIGR01865 710127002075 CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720 710127002076 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 710127002077 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 710127002078 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 710127002079 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 710127002080 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 710127002081 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 710127002082 active site 710127002083 HIGH motif; other site 710127002084 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 710127002085 KMSKS motif; other site 710127002086 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 710127002087 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 710127002088 active site 710127002089 catalytic triad [active] 710127002090 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 710127002091 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 710127002092 Walker A motif; other site 710127002093 ATP binding site [chemical binding]; other site 710127002094 Walker B motif; other site 710127002095 arginine finger; other site 710127002096 HsdM N-terminal domain; Region: HsdM_N; pfam12161 710127002097 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 710127002098 Potential MGA_0539/40 type I restriction-modification system specificity (S) subunit gene region.; MGRL737f 710127002099 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 710127002100 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 710127002101 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 710127002102 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 710127002103 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 710127002104 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 710127002105 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710127002106 ATP binding site [chemical binding]; other site 710127002107 putative Mg++ binding site [ion binding]; other site 710127002108 Herpesvirus UL31-like protein; Region: Herpes_UL31; cl17783 710127002109 Putative peptidase (DUF31); Region: DUF31; pfam01732 710127002110 Putative peptidase (DUF31); Region: DUF31; pfam01732 710127002111 Region encodes amino acid sequences similar to N-terminal regions of conserved hypothetical proteins predicted in M. synoviae 710127002112 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 710127002113 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 710127002114 nucleotide binding pocket [chemical binding]; other site 710127002115 K-X-D-G motif; other site 710127002116 catalytic site [active] 710127002117 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 710127002118 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 710127002119 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 710127002120 Dimer interface [polypeptide binding]; other site 710127002121 methionine sulfoxide reductase A; Provisional; Region: PRK14054 710127002122 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 710127002123 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 710127002124 ATP binding site [chemical binding]; other site 710127002125 putative Mg++ binding site [ion binding]; other site 710127002126 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 710127002127 nucleotide binding region [chemical binding]; other site 710127002128 ATP-binding site [chemical binding]; other site 710127002129 Potential MGA_0578 conserved hypothetical protein gene region; MGRL763 710127002130 Putative peptidase (DUF31); Region: DUF31; pfam01732 710127002131 Putative peptidase (DUF31); Region: DUF31; pfam01732 710127002132 Potential MGA_0584/3 conserved hypothetical protein gene region; MGRL766 710127002133 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 710127002134 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 710127002135 NAD(P) binding site [chemical binding]; other site 710127002136 catalytic residues [active] 710127002137 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 710127002138 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 710127002139 Zn2+ binding site [ion binding]; other site 710127002140 Mg2+ binding site [ion binding]; other site 710127002141 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 710127002142 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 710127002143 HIGH motif; other site 710127002144 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 710127002145 active site 710127002146 KMSKS motif; other site 710127002147 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 710127002148 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 710127002149 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 710127002150 NAD(P) binding pocket [chemical binding]; other site 710127002151 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 710127002152 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 710127002153 Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679 710127002154 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 710127002155 Hpr binding site; other site 710127002156 active site 710127002157 homohexamer subunit interaction site [polypeptide binding]; other site 710127002158 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 710127002159 active site 710127002160 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 710127002161 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 710127002162 trmE is a tRNA modification GTPase; Region: trmE; cd04164 710127002163 G1 box; other site 710127002164 GTP/Mg2+ binding site [chemical binding]; other site 710127002165 Switch I region; other site 710127002166 G2 box; other site 710127002167 Switch II region; other site 710127002168 G3 box; other site 710127002169 G4 box; other site 710127002170 G5 box; other site 710127002171 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 710127002172 DNA polymerase III subunit delta'; Validated; Region: PRK05818 710127002173 thymidylate kinase; Validated; Region: tmk; PRK00698 710127002174 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 710127002175 TMP-binding site; other site 710127002176 ATP-binding site [chemical binding]; other site 710127002177 seryl-tRNA synthetase; Provisional; Region: PRK05431 710127002178 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 710127002179 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 710127002180 dimer interface [polypeptide binding]; other site 710127002181 active site 710127002182 motif 1; other site 710127002183 motif 2; other site 710127002184 motif 3; other site 710127002185 DNA gyrase subunit A; Validated; Region: PRK05560 710127002186 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 710127002187 CAP-like domain; other site 710127002188 active site 710127002189 primary dimer interface [polypeptide binding]; other site 710127002190 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 710127002191 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 710127002192 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 710127002193 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 710127002194 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 710127002195 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 710127002196 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 710127002197 ATP binding site [chemical binding]; other site 710127002198 Mg2+ binding site [ion binding]; other site 710127002199 G-X-G motif; other site 710127002200 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 710127002201 anchoring element; other site 710127002202 dimer interface [polypeptide binding]; other site 710127002203 ATP binding site [chemical binding]; other site 710127002204 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 710127002205 active site 710127002206 putative metal-binding site [ion binding]; other site 710127002207 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 710127002208 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 710127002209 HSP70 interaction site [polypeptide binding]; other site 710127002210 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 710127002211 putative DNA binding surface [nucleotide binding]; other site 710127002212 DNA polymerase III beta subunit; Region: POL3Bc; smart00480 710127002213 dimer interface [polypeptide binding]; other site 710127002214 beta-clamp/clamp loader binding surface; other site 710127002215 beta-clamp/translesion DNA polymerase binding surface; other site