-- dump date 20140619_160546 -- class Genbank::misc_feature -- table misc_feature_note -- id note 243273000001 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 243273000002 DNA polymerase III beta subunit; Region: POL3Bc; smart00480 243273000003 putative DNA binding surface [nucleotide binding]; other site 243273000004 dimer interface [polypeptide binding]; other site 243273000005 beta-clamp/clamp loader binding surface; other site 243273000006 beta-clamp/translesion DNA polymerase binding surface; other site 243273000007 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 243273000008 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 243273000009 HSP70 interaction site [polypeptide binding]; other site 243273000010 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 243273000011 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243273000012 ATP binding site [chemical binding]; other site 243273000013 Mg2+ binding site [ion binding]; other site 243273000014 G-X-G motif; other site 243273000015 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 243273000016 anchoring element; other site 243273000017 dimer interface [polypeptide binding]; other site 243273000018 ATP binding site [chemical binding]; other site 243273000019 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 243273000020 active site 243273000021 putative metal-binding site [ion binding]; other site 243273000022 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 243273000023 DNA gyrase, A subunit; Region: gyrA; TIGR01063 243273000024 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 243273000025 CAP-like domain; other site 243273000026 active site 243273000027 primary dimer interface [polypeptide binding]; other site 243273000028 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 243273000029 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 243273000030 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 243273000031 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 243273000032 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 243273000033 seryl-tRNA synthetase; Region: serS; TIGR00414 243273000034 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 243273000035 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 243273000036 dimer interface [polypeptide binding]; other site 243273000037 active site 243273000038 motif 1; other site 243273000039 motif 2; other site 243273000040 motif 3; other site 243273000041 thymidylate kinase; Region: DTMP_kinase; TIGR00041 243273000042 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 243273000043 TMP-binding site; other site 243273000044 ATP-binding site [chemical binding]; other site 243273000045 DNA polymerase III subunit delta'; Validated; Region: PRK05818 243273000046 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 243273000047 tRNA modification GTPase TrmE; Region: mnmE_trmE_thdF; TIGR00450 243273000048 trmE is a tRNA modification GTPase; Region: trmE; cd04164 243273000049 G1 box; other site 243273000050 GTP/Mg2+ binding site [chemical binding]; other site 243273000051 Switch I region; other site 243273000052 G2 box; other site 243273000053 Switch II region; other site 243273000054 G3 box; other site 243273000055 G4 box; other site 243273000056 G5 box; other site 243273000057 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 243273000058 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 243273000059 active site 243273000060 DNA primase-related protein; Region: MG010; TIGR00646 243273000061 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 243273000062 active site 243273000063 metal binding site [ion binding]; metal-binding site 243273000064 interdomain interaction site; other site 243273000065 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 243273000066 ATP-grasp domain; Region: ATP-grasp_4; cl17255 243273000067 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 243273000068 ATP-grasp domain; Region: ATP-grasp_4; cl17255 243273000069 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 243273000070 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 243273000071 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 243273000072 homodimer interface [polypeptide binding]; other site 243273000073 NADP binding site [chemical binding]; other site 243273000074 substrate binding site [chemical binding]; other site 243273000075 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 243273000076 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 243273000077 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243273000078 Walker A/P-loop; other site 243273000079 ATP binding site [chemical binding]; other site 243273000080 Q-loop/lid; other site 243273000081 ABC transporter signature motif; other site 243273000082 Walker B; other site 243273000083 D-loop; other site 243273000084 H-loop/switch region; other site 243273000085 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 243273000086 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 243273000087 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 243273000088 Walker A/P-loop; other site 243273000089 ATP binding site [chemical binding]; other site 243273000090 Q-loop/lid; other site 243273000091 ABC transporter signature motif; other site 243273000092 Walker B; other site 243273000093 D-loop; other site 243273000094 H-loop/switch region; other site 243273000095 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 243273000096 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243273000097 ATP binding site [chemical binding]; other site 243273000098 putative Mg++ binding site [ion binding]; other site 243273000099 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243273000100 nucleotide binding region [chemical binding]; other site 243273000101 ATP-binding site [chemical binding]; other site 243273000102 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 243273000103 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 243273000104 HSP70 interaction site [polypeptide binding]; other site 243273000105 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 243273000106 Zn binding sites [ion binding]; other site 243273000107 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 243273000108 substrate binding site [polypeptide binding]; other site 243273000109 dimer interface [polypeptide binding]; other site 243273000110 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 243273000111 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 243273000112 methionyl-tRNA synthetase; Region: metG; TIGR00398 243273000113 active site 243273000114 HIGH motif; other site 243273000115 KMSKS motif; other site 243273000116 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 243273000117 tRNA binding surface [nucleotide binding]; other site 243273000118 anticodon binding site; other site 243273000119 DNA-directed RNA polymerase, delta subunit [Transcription]; Region: RpoE; COG3343 243273000120 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 243273000121 intersubunit interface [polypeptide binding]; other site 243273000122 active site 243273000123 zinc binding site [ion binding]; other site 243273000124 Na+ binding site [ion binding]; other site 243273000125 GTP-binding protein YchF; Reviewed; Region: PRK09601 243273000126 YchF GTPase; Region: YchF; cd01900 243273000127 G1 box; other site 243273000128 GTP/Mg2+ binding site [chemical binding]; other site 243273000129 Switch I region; other site 243273000130 G2 box; other site 243273000131 Switch II region; other site 243273000132 G3 box; other site 243273000133 G4 box; other site 243273000134 G5 box; other site 243273000135 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 243273000136 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 243273000137 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 243273000138 active site 243273000139 translation elongation factor P; Region: efp; TIGR00038 243273000140 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 243273000141 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 243273000142 RNA binding site [nucleotide binding]; other site 243273000143 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 243273000144 RNA binding site [nucleotide binding]; other site 243273000145 Domain of unknown function (DUF1948); Region: DUF1948; pfam09185 243273000146 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 243273000147 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 243273000148 conserved cys residue [active] 243273000149 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243273000150 active site 243273000151 DNA polymerase III, alpha subunit (gram-positive type) [DNA replication, recombination, and repair]; Region: PolC; COG2176 243273000152 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 243273000153 generic binding surface II; other site 243273000154 generic binding surface I; other site 243273000155 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 243273000156 active site 243273000157 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 243273000158 active site 243273000159 catalytic site [active] 243273000160 substrate binding site [chemical binding]; other site 243273000161 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 243273000162 MG032/MG096/MG288 family 2; Region: DUF240; pfam03086 243273000163 MG032/MG096/MG288 family 1; Region: DUF237; pfam03072 243273000164 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 243273000165 amphipathic channel; other site 243273000166 Asn-Pro-Ala signature motifs; other site 243273000167 Thymidine kinase [Nucleotide transport and metabolism]; Region: Tdk; COG1435 243273000168 histidyl-tRNA synthetase; Region: hisS; TIGR00442 243273000169 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 243273000170 dimer interface [polypeptide binding]; other site 243273000171 motif 1; other site 243273000172 active site 243273000173 motif 2; other site 243273000174 motif 3; other site 243273000175 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 243273000176 anticodon binding site; other site 243273000177 aspartyl-tRNA synthetase, bacterial type; Region: aspS_bact; TIGR00459 243273000178 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 243273000179 Dimer interface [polypeptide binding]; other site 243273000180 anticodon binding site; other site 243273000181 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 243273000182 homodimer interface [polypeptide binding]; other site 243273000183 motif 1; other site 243273000184 active site 243273000185 motif 2; other site 243273000186 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 243273000187 active site 243273000188 motif 3; other site 243273000189 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 243273000190 Nicotinate phosphoribosyltransferase (NAPRTase) family; Region: NAPRTase; pfam04095 243273000191 active site 243273000192 glycerol kinase; Provisional; Region: glpK; PRK00047 243273000193 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 243273000194 N- and C-terminal domain interface [polypeptide binding]; other site 243273000195 active site 243273000196 MgATP binding site [chemical binding]; other site 243273000197 catalytic site [active] 243273000198 metal binding site [ion binding]; metal-binding site 243273000199 glycerol binding site [chemical binding]; other site 243273000200 homotetramer interface [polypeptide binding]; other site 243273000201 homodimer interface [polypeptide binding]; other site 243273000202 FBP binding site [chemical binding]; other site 243273000203 protein IIAGlc interface [polypeptide binding]; other site 243273000204 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 243273000205 hydroxyglutarate oxidase; Provisional; Region: PRK11728 243273000206 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 243273000207 Basic membrane protein; Region: Bmp; pfam02608 243273000208 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 243273000209 dimerization domain swap beta strand [polypeptide binding]; other site 243273000210 regulatory protein interface [polypeptide binding]; other site 243273000211 active site 243273000212 regulatory phosphorylation site [posttranslational modification]; other site 243273000213 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 243273000214 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243273000215 Walker A/P-loop; other site 243273000216 ATP binding site [chemical binding]; other site 243273000217 Q-loop/lid; other site 243273000218 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 243273000219 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243273000220 ABC transporter signature motif; other site 243273000221 Walker B; other site 243273000222 D-loop; other site 243273000223 H-loop/switch region; other site 243273000224 TOBE domain; Region: TOBE_2; pfam08402 243273000225 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 243273000226 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243273000227 dimer interface [polypeptide binding]; other site 243273000228 conserved gate region; other site 243273000229 putative PBP binding loops; other site 243273000230 ABC-ATPase subunit interface; other site 243273000231 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 243273000232 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243273000233 dimer interface [polypeptide binding]; other site 243273000234 conserved gate region; other site 243273000235 putative PBP binding loops; other site 243273000236 ABC-ATPase subunit interface; other site 243273000237 Hypothetical lipoprotein (MG045 family); Region: Lipoprotein_8; pfam02030 243273000238 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 243273000239 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 243273000240 metallohydrolase, glycoprotease/Kae1 family; Region: gcp_kae1; TIGR00329 243273000241 S-adenosylmethionine synthetase; Region: metK; TIGR01034 243273000242 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 243273000243 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 243273000244 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 243273000245 signal recognition particle protein; Region: ffh; TIGR00959 243273000246 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 243273000247 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 243273000248 Signal peptide binding domain; Region: SRP_SPB; pfam02978 243273000249 purine-nucleoside phosphorylase, family 1 (deoD); Region: deoD; TIGR00107 243273000250 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 243273000251 intersubunit interface [polypeptide binding]; other site 243273000252 active site 243273000253 catalytic residue [active] 243273000254 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 243273000255 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 243273000256 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 243273000257 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 243273000258 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 243273000259 active site 243273000260 catalytic motif [active] 243273000261 Zn binding site [ion binding]; other site 243273000262 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 243273000263 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 243273000264 active site 243273000265 substrate binding site [chemical binding]; other site 243273000266 metal binding site [ion binding]; metal-binding site 243273000267 NusG family protein; Region: NusG_myco; TIGR01956 243273000268 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 243273000269 putative homodimer interface [polypeptide binding]; other site 243273000270 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 243273000271 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 243273000272 probable S-adenosylmethionine-dependent methyltransferase, YraL family; Region: TIGR00096 243273000273 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 243273000274 putative SAM binding site [chemical binding]; other site 243273000275 putative homodimer interface [polypeptide binding]; other site 243273000276 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 243273000277 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 243273000278 putative active site [active] 243273000279 putative metal binding site [ion binding]; other site 243273000280 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK00553 243273000281 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 243273000282 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243273000283 active site 243273000284 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 243273000285 SmpB-tmRNA interface; other site 243273000286 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 243273000287 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 243273000288 active site 243273000289 Mycoplasma MFS transporter; Region: MFS_Mycoplasma; pfam07672 243273000290 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 243273000291 active site 243273000292 phosphorylation site [posttranslational modification] 243273000293 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 243273000294 active site 243273000295 P-loop; other site 243273000296 phosphorylation site [posttranslational modification] 243273000297 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 243273000298 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 243273000299 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 243273000300 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 243273000301 putative substrate binding site [chemical binding]; other site 243273000302 putative ATP binding site [chemical binding]; other site 243273000303 FtsX-like permease family; Region: FtsX; pfam02687 243273000304 FtsX-like permease family; Region: FtsX; pfam02687 243273000305 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 243273000306 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 243273000307 Walker A/P-loop; other site 243273000308 ATP binding site [chemical binding]; other site 243273000309 Q-loop/lid; other site 243273000310 ABC transporter signature motif; other site 243273000311 Walker B; other site 243273000312 D-loop; other site 243273000313 H-loop/switch region; other site 243273000314 transketolase, bacterial and yeast; Region: tktlase_bact; TIGR00232 243273000315 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 243273000316 TPP-binding site [chemical binding]; other site 243273000317 dimer interface [polypeptide binding]; other site 243273000318 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 243273000319 PYR/PP interface [polypeptide binding]; other site 243273000320 dimer interface [polypeptide binding]; other site 243273000321 TPP binding site [chemical binding]; other site 243273000322 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 243273000323 Putative peptidase (DUF31); Region: DUF31; pfam01732 243273000324 Putative peptidase (DUF31); Region: DUF31; pfam01732 243273000325 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 243273000326 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 243273000327 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 243273000328 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 243273000329 active site turn [active] 243273000330 phosphorylation site [posttranslational modification] 243273000331 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 243273000332 HPr interaction site; other site 243273000333 glycerol kinase (GK) interaction site [polypeptide binding]; other site 243273000334 active site 243273000335 phosphorylation site [posttranslational modification] 243273000336 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 243273000337 rRNA interaction site [nucleotide binding]; other site 243273000338 S8 interaction site; other site 243273000339 putative laminin-1 binding site; other site 243273000340 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 243273000341 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 243273000342 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 243273000343 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 243273000344 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 243273000345 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 243273000346 preprotein translocase, SecA subunit; Region: secA; TIGR00963 243273000347 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 243273000348 excinuclease ABC, B subunit; Region: uvrb; TIGR00631 243273000349 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 243273000350 ATP binding site [chemical binding]; other site 243273000351 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243273000352 nucleotide binding region [chemical binding]; other site 243273000353 ATP-binding site [chemical binding]; other site 243273000354 Ultra-violet resistance protein B; Region: UvrB; pfam12344 243273000355 UvrB/uvrC motif; Region: UVR; pfam02151 243273000356 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 243273000357 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243273000358 dimer interface [polypeptide binding]; other site 243273000359 conserved gate region; other site 243273000360 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 243273000361 ABC-ATPase subunit interface; other site 243273000362 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 243273000363 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243273000364 dimer interface [polypeptide binding]; other site 243273000365 conserved gate region; other site 243273000366 putative PBP binding loops; other site 243273000367 ABC-ATPase subunit interface; other site 243273000368 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 243273000369 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 243273000370 Walker A/P-loop; other site 243273000371 ATP binding site [chemical binding]; other site 243273000372 Q-loop/lid; other site 243273000373 ABC transporter signature motif; other site 243273000374 Walker B; other site 243273000375 D-loop; other site 243273000376 H-loop/switch region; other site 243273000377 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 243273000378 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243273000379 Walker A/P-loop; other site 243273000380 ATP binding site [chemical binding]; other site 243273000381 Q-loop/lid; other site 243273000382 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 243273000383 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 243273000384 ABC transporter signature motif; other site 243273000385 Walker B; other site 243273000386 D-loop; other site 243273000387 H-loop/switch region; other site 243273000388 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 243273000389 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 243273000390 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 243273000391 23S rRNA interface [nucleotide binding]; other site 243273000392 L7/L12 interface [polypeptide binding]; other site 243273000393 putative thiostrepton binding site; other site 243273000394 L25 interface [polypeptide binding]; other site 243273000395 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 243273000396 mRNA/rRNA interface [nucleotide binding]; other site 243273000397 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 243273000398 putative active site [active] 243273000399 catalytic residue [active] 243273000400 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 243273000401 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 243273000402 Ligand Binding Site [chemical binding]; other site 243273000403 Serine kinase of the HPr protein, regulates carbohydrate metabolism [Signal transduction mechanisms]; Region: HprK; COG1493 243273000404 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 243273000405 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 243273000406 Hpr binding site; other site 243273000407 active site 243273000408 homohexamer subunit interaction site [polypeptide binding]; other site 243273000409 prolipoprotein diacylglyceryl transferase; Region: lgt; TIGR00544 243273000410 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 243273000411 16S rRNA interaction site [nucleotide binding]; other site 243273000412 streptomycin interaction site [chemical binding]; other site 243273000413 23S rRNA interaction site [nucleotide binding]; other site 243273000414 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 243273000415 30S ribosomal protein S7; Validated; Region: PRK05302 243273000416 elongation factor G; Reviewed; Region: PRK12739 243273000417 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 243273000418 G1 box; other site 243273000419 putative GEF interaction site [polypeptide binding]; other site 243273000420 GTP/Mg2+ binding site [chemical binding]; other site 243273000421 Switch I region; other site 243273000422 G2 box; other site 243273000423 G3 box; other site 243273000424 Switch II region; other site 243273000425 G4 box; other site 243273000426 G5 box; other site 243273000427 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 243273000428 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 243273000429 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 243273000430 ribosomal protein S6; Region: S6; TIGR00166 243273000431 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 243273000432 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 243273000433 dimer interface [polypeptide binding]; other site 243273000434 ssDNA binding site [nucleotide binding]; other site 243273000435 tetramer (dimer of dimers) interface [polypeptide binding]; other site 243273000436 ribosomal protein S18; Region: S18; TIGR00165 243273000437 ribosomal protein L9; Region: L9; TIGR00158 243273000438 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 243273000439 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 243273000440 Replicative DNA helicase [DNA replication, recombination, and repair]; Region: DnaB; COG0305 243273000441 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 243273000442 Walker A motif; other site 243273000443 ATP binding site [chemical binding]; other site 243273000444 Walker B motif; other site 243273000445 DNA binding loops [nucleotide binding] 243273000446 MG032/MG096/MG288 family 2; Region: DUF240; pfam03086 243273000447 MG032/MG096/MG288 family 1; Region: DUF237; pfam03072 243273000448 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 243273000449 ligand binding site [chemical binding]; other site 243273000450 active site 243273000451 UGI interface [polypeptide binding]; other site 243273000452 catalytic site [active] 243273000453 aspartyl/glutamyl-tRNA amidotransferase subunit C-like protein; Provisional; Region: PRK12821 243273000454 hypothetical protein; Provisional; Region: PRK09609 243273000455 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit; Region: gatC; TIGR00135 243273000456 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 243273000457 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, A subunit; Region: gatA; TIGR00132 243273000458 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, B subunit; Region: gatB; TIGR00133 243273000459 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 243273000460 GatB domain; Region: GatB_Yqey; pfam02637 243273000461 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 243273000462 DNA-binding site [nucleotide binding]; DNA binding site 243273000463 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 243273000464 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 243273000465 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243273000466 conserved hypothetical protein; Region: MG103; TIGR00647 243273000467 Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains; Region: RhoGEF; cl02571 243273000468 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 243273000469 VacB and RNase II family 3'-5' exoribonucleases; Region: 3_prime_RNase; TIGR00358 243273000470 Cold shock protein domain; Region: CSP; smart00357 243273000471 RNB domain; Region: RNB; pfam00773 243273000472 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 243273000473 RNA binding site [nucleotide binding]; other site 243273000474 TIGR00159 family protein; Region: TIGR00159 243273000475 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 243273000476 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 243273000477 active site 243273000478 catalytic residues [active] 243273000479 metal binding site [ion binding]; metal-binding site 243273000480 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 243273000481 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 243273000482 catalytic site [active] 243273000483 G-X2-G-X-G-K; other site 243273000484 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 243273000485 Protein phosphatase 2C; Region: PP2C; pfam00481 243273000486 active site 243273000487 Protein kinase domain; Region: Pkinase; pfam00069 243273000488 Catalytic domain of Protein Kinases; Region: PKc; cd00180 243273000489 active site 243273000490 ATP binding site [chemical binding]; other site 243273000491 substrate binding site [chemical binding]; other site 243273000492 activation loop (A-loop); other site 243273000493 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 243273000494 RNA binding site [nucleotide binding]; other site 243273000495 ribosome small subunit-dependent GTPase A; Region: TIGR00157 243273000496 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 243273000497 GTPase/Zn-binding domain interface [polypeptide binding]; other site 243273000498 GTP/Mg2+ binding site [chemical binding]; other site 243273000499 G4 box; other site 243273000500 G5 box; other site 243273000501 G1 box; other site 243273000502 Switch I region; other site 243273000503 G2 box; other site 243273000504 G3 box; other site 243273000505 Switch II region; other site 243273000506 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 243273000507 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 243273000508 active site 243273000509 dimer interface [polypeptide binding]; other site 243273000510 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 243273000511 dimer interface [polypeptide binding]; other site 243273000512 active site 243273000513 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 243273000514 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 243273000515 substrate binding site [chemical binding]; other site 243273000516 hexamer interface [polypeptide binding]; other site 243273000517 metal binding site [ion binding]; metal-binding site 243273000518 asparaginyl-tRNA synthetase; Region: asnS; TIGR00457 243273000519 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 243273000520 putative dimer interface [polypeptide binding]; other site 243273000521 putative anticodon binding site; other site 243273000522 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 243273000523 motif 1; other site 243273000524 dimer interface [polypeptide binding]; other site 243273000525 active site 243273000526 motif 2; other site 243273000527 motif 3; other site 243273000528 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 243273000529 competence/damage-inducible protein CinA C-terminal domain; Region: cinA_cterm; TIGR00199 243273000530 4-diphosphocytidyl-2-methyl-D-erithritol synthase [Lipid metabolism]; Region: IspD; COG1211 243273000531 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 243273000532 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 243273000533 NAD binding site [chemical binding]; other site 243273000534 homodimer interface [polypeptide binding]; other site 243273000535 active site 243273000536 substrate binding site [chemical binding]; other site 243273000537 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 243273000538 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 243273000539 Walker A/P-loop; other site 243273000540 ATP binding site [chemical binding]; other site 243273000541 Q-loop/lid; other site 243273000542 ABC transporter signature motif; other site 243273000543 Walker B; other site 243273000544 D-loop; other site 243273000545 H-loop/switch region; other site 243273000546 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 243273000547 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 243273000548 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 243273000549 TM-ABC transporter signature motif; other site 243273000550 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 243273000551 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 243273000552 TM-ABC transporter signature motif; other site 243273000553 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 243273000554 DNA topoisomerase I, bacterial; Region: topA_bact; TIGR01051 243273000555 active site 243273000556 interdomain interaction site; other site 243273000557 putative metal-binding site [ion binding]; other site 243273000558 nucleotide binding site [chemical binding]; other site 243273000559 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 243273000560 domain I; other site 243273000561 phosphate binding site [ion binding]; other site 243273000562 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 243273000563 domain II; other site 243273000564 domain III; other site 243273000565 nucleotide binding site [chemical binding]; other site 243273000566 DNA binding groove [nucleotide binding] 243273000567 catalytic site [active] 243273000568 domain IV; other site 243273000569 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 243273000570 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 243273000571 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 243273000572 hypothetical protein; Provisional; Region: PRK12705 243273000573 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 243273000574 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 243273000575 catalytic residues [active] 243273000576 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 243273000577 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 243273000578 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 243273000579 active site 243273000580 HIGH motif; other site 243273000581 dimer interface [polypeptide binding]; other site 243273000582 KMSKS motif; other site 243273000583 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 243273000584 ArsC family; Region: ArsC; pfam03960 243273000585 putative catalytic residues [active] 243273000586 thiol/disulfide switch; other site 243273000587 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK00561 243273000588 ATP-NAD kinase; Region: NAD_kinase; pfam01513 243273000589 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 243273000590 active site turn [active] 243273000591 phosphorylation site [posttranslational modification] 243273000592 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 243273000593 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243273000594 Zn2+ binding site [ion binding]; other site 243273000595 Mg2+ binding site [ion binding]; other site 243273000596 similar to hypothetical proteins from other bacteria; contains a frameshift 243273000597 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 243273000598 HIT family signature motif; other site 243273000599 catalytic residue [active] 243273000600 Protein of unknown function (DUF1600); Region: DUF1600; pfam07667 243273000601 DNA-binding protein, YbaB/EbfC family; Region: DNA_YbaB_EbfC; TIGR00103 243273000602 lysyl-tRNA synthetase, eukaryotic and non-spirochete bacterial; Region: lysS_bact; TIGR00499 243273000603 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 243273000604 dimer interface [polypeptide binding]; other site 243273000605 putative anticodon binding site; other site 243273000606 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 243273000607 motif 1; other site 243273000608 active site 243273000609 motif 2; other site 243273000610 motif 3; other site 243273000611 UDP-galactopyranose mutase; Region: UDP-GALP_mutase; TIGR00031 243273000612 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 243273000613 UDP-galactopyranose mutase; Region: GLF; pfam03275 243273000614 Membrane GTPase LepA [Cell envelope biogenesis, outer membrane]; Region: LepA; COG0481 243273000615 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 243273000616 G1 box; other site 243273000617 putative GEF interaction site [polypeptide binding]; other site 243273000618 GTP/Mg2+ binding site [chemical binding]; other site 243273000619 Switch I region; other site 243273000620 G2 box; other site 243273000621 G3 box; other site 243273000622 Switch II region; other site 243273000623 G4 box; other site 243273000624 G5 box; other site 243273000625 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 243273000626 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 243273000627 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 243273000628 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 243273000629 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 243273000630 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 243273000631 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 243273000632 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 243273000633 AAA domain; Region: AAA_12; pfam13087 243273000634 transcription termination factor NusA; Region: NusA; TIGR01953 243273000635 NusA N-terminal domain; Region: NusA_N; pfam08529 243273000636 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 243273000637 RNA binding site [nucleotide binding]; other site 243273000638 NusA-like KH domain; Region: KH_5; pfam13184 243273000639 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 243273000640 G-X-X-G motif; other site 243273000641 Protein of unknown function (DUF448); Region: DUF448; pfam04296 243273000642 putative RNA binding cleft [nucleotide binding]; other site 243273000643 translation initiation factor IF-2; Region: IF-2; TIGR00487 243273000644 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 243273000645 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 243273000646 G1 box; other site 243273000647 putative GEF interaction site [polypeptide binding]; other site 243273000648 GTP/Mg2+ binding site [chemical binding]; other site 243273000649 Switch I region; other site 243273000650 G2 box; other site 243273000651 G3 box; other site 243273000652 Switch II region; other site 243273000653 G4 box; other site 243273000654 G5 box; other site 243273000655 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 243273000656 Translation-initiation factor 2; Region: IF-2; pfam11987 243273000657 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 243273000658 ribosome-binding factor A; Region: rbfA; TIGR00082 243273000659 riboflavin kinase/FMN adenylyltransferase; Region: ribF; TIGR00083 243273000660 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 243273000661 active site 243273000662 nucleotide binding site [chemical binding]; other site 243273000663 HIGH motif; other site 243273000664 KMSKS motif; other site 243273000665 Riboflavin kinase; Region: Flavokinase; smart00904 243273000666 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 243273000667 Domain of unknown function DUF21; Region: DUF21; pfam01595 243273000668 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 243273000669 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 243273000670 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 243273000671 ribosomal protein S10, bacterial/organelle; Region: rpsJ_bact; TIGR01049 243273000672 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 243273000673 Ribosomal protein L4 [Translation, ribosomal structure and biogenesis]; Region: RplD; COG0088 243273000674 Ribosomal protein L23 [Translation, ribosomal structure and biogenesis]; Region: RplW; COG0089 243273000675 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 243273000676 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 243273000677 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 243273000678 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 243273000679 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 243273000680 putative translocon binding site; other site 243273000681 protein-rRNA interface [nucleotide binding]; other site 243273000682 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 243273000683 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 243273000684 G-X-X-G motif; other site 243273000685 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 243273000686 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 243273000687 23S rRNA interface [nucleotide binding]; other site 243273000688 5S rRNA interface [nucleotide binding]; other site 243273000689 putative antibiotic binding site [chemical binding]; other site 243273000690 L25 interface [polypeptide binding]; other site 243273000691 L27 interface [polypeptide binding]; other site 243273000692 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 243273000693 23S rRNA interface [nucleotide binding]; other site 243273000694 putative translocon interaction site; other site 243273000695 signal recognition particle (SRP54) interaction site; other site 243273000696 L23 interface [polypeptide binding]; other site 243273000697 trigger factor interaction site; other site 243273000698 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 243273000699 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 243273000700 ribosomal protein L24, bacterial/organelle; Region: rplX_bact; TIGR01079 243273000701 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 243273000702 RNA binding site [nucleotide binding]; other site 243273000703 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 243273000704 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 243273000705 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 243273000706 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 243273000707 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 243273000708 ribosomal protein L6, bacterial type; Region: L6_bact; TIGR03654 243273000709 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 243273000710 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 243273000711 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 243273000712 5S rRNA interface [nucleotide binding]; other site 243273000713 23S rRNA interface [nucleotide binding]; other site 243273000714 L5 interface [polypeptide binding]; other site 243273000715 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 243273000716 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 243273000717 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 243273000718 ribosomal protein L15, bacterial/organelle; Region: rplO_bact; TIGR01071 243273000719 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 243273000720 SecY translocase; Region: SecY; pfam00344 243273000721 adenylate kinase; Region: adk; TIGR01351 243273000722 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 243273000723 AMP-binding site [chemical binding]; other site 243273000724 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 243273000725 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 243273000726 active site 243273000727 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 243273000728 rRNA binding site [nucleotide binding]; other site 243273000729 predicted 30S ribosome binding site; other site 243273000730 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 243273000731 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 243273000732 30S ribosomal protein S13; Region: bact_S13; TIGR03631 243273000733 30S ribosomal protein S11; Validated; Region: PRK05309 243273000734 DNA-directed RNA polymerase, alpha subunit, bacterial and chloroplast-type; Region: rpoA; TIGR02027 243273000735 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 243273000736 alphaNTD - beta interaction site [polypeptide binding]; other site 243273000737 alphaNTD homodimer interface [polypeptide binding]; other site 243273000738 alphaNTD - beta' interaction site [polypeptide binding]; other site 243273000739 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 243273000740 ribosomal protein L17; Region: L17; TIGR00059 243273000741 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13632 243273000742 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 243273000743 Walker A/P-loop; other site 243273000744 ATP binding site [chemical binding]; other site 243273000745 Q-loop/lid; other site 243273000746 ABC transporter signature motif; other site 243273000747 Walker B; other site 243273000748 D-loop; other site 243273000749 H-loop/switch region; other site 243273000750 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13631 243273000751 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 243273000752 Walker A/P-loop; other site 243273000753 ATP binding site [chemical binding]; other site 243273000754 Q-loop/lid; other site 243273000755 ABC transporter signature motif; other site 243273000756 Walker B; other site 243273000757 D-loop; other site 243273000758 H-loop/switch region; other site 243273000759 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 243273000760 Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101 243273000761 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 243273000762 dimerization interface 3.5A [polypeptide binding]; other site 243273000763 active site 243273000764 oligoendopeptidase F; Region: pepF; TIGR00181 243273000765 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 243273000766 active site 243273000767 Zn binding site [ion binding]; other site 243273000768 Adenine-specific methyltransferase EcoRI; Region: EcoRI_methylase; pfam13651 243273000769 Mycoplasma MG185/MG260 protein; Region: Lipoprotein_X; pfam03305 243273000770 Putative mycoplasma lipoprotein, C-terminal region; Region: Lipoprotein_10; pfam03202 243273000771 Staphylococcal nuclease homologues; Region: SNc; smart00318 243273000772 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 243273000773 Catalytic site; other site 243273000774 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 243273000775 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243273000776 Walker A/P-loop; other site 243273000777 ATP binding site [chemical binding]; other site 243273000778 Q-loop/lid; other site 243273000779 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 243273000780 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243273000781 ABC transporter signature motif; other site 243273000782 Walker B; other site 243273000783 D-loop; other site 243273000784 H-loop/switch region; other site 243273000785 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243273000786 dimer interface [polypeptide binding]; other site 243273000787 conserved gate region; other site 243273000788 putative PBP binding loops; other site 243273000789 ABC-ATPase subunit interface; other site 243273000790 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 243273000791 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243273000792 dimer interface [polypeptide binding]; other site 243273000793 conserved gate region; other site 243273000794 putative PBP binding loops; other site 243273000795 ABC-ATPase subunit interface; other site 243273000796 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 243273000797 DHH family; Region: DHH; pfam01368 243273000798 DHHA1 domain; Region: DHHA1; pfam02272 243273000799 adhesin P1; Region: termin_org_P1; TIGR03839 243273000800 Trypsin-sensitive surface-exposed protein; Region: CytadhesinP1; pfam12378 243273000801 Trypsin-sensitive surface-exposed protein; Region: CytadhesinP1; pfam12378 243273000802 Mycoplasma adhesin P1; Region: Adhesin_P1; pfam03257 243273000803 MgpC protein precursor; Region: MgpC; pfam05220 243273000804 phenylalanyl-tRNA synthetase, alpha subunit; Region: pheS; TIGR00468 243273000805 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 243273000806 dimer interface [polypeptide binding]; other site 243273000807 motif 1; other site 243273000808 active site 243273000809 motif 2; other site 243273000810 motif 3; other site 243273000811 phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial; Region: pheT_bact; TIGR00472 243273000812 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 243273000813 putative tRNA-binding site [nucleotide binding]; other site 243273000814 B3/4 domain; Region: B3_4; pfam03483 243273000815 tRNA synthetase B5 domain; Region: B5; pfam03484 243273000816 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 243273000817 dimer interface [polypeptide binding]; other site 243273000818 motif 1; other site 243273000819 motif 3; other site 243273000820 motif 2; other site 243273000821 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 243273000822 translation initiation factor IF-3; Region: infC; TIGR00168 243273000823 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 243273000824 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 243273000825 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 243273000826 23S rRNA binding site [nucleotide binding]; other site 243273000827 L21 binding site [polypeptide binding]; other site 243273000828 L13 binding site [polypeptide binding]; other site 243273000829 similar to ribonuclease HIII; contains a frameshift 243273000830 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 243273000831 HSP70 interaction site [polypeptide binding]; other site 243273000832 EAGR box; Region: EAGR_box; TIGR03834 243273000833 terminal organelle assembly protein TopJ; Region: termin_org_DnaJ; TIGR03835 243273000834 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 243273000835 substrate binding site [polypeptide binding]; other site 243273000836 dimer interface [polypeptide binding]; other site 243273000837 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 243273000838 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 243273000839 dimer interface [polypeptide binding]; other site 243273000840 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 243273000841 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 243273000842 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 243273000843 ATP binding site [chemical binding]; other site 243273000844 Mg2+ binding site [ion binding]; other site 243273000845 G-X-G motif; other site 243273000846 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 243273000847 anchoring element; other site 243273000848 dimer interface [polypeptide binding]; other site 243273000849 ATP binding site [chemical binding]; other site 243273000850 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 243273000851 active site 243273000852 metal binding site [ion binding]; metal-binding site 243273000853 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 243273000854 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 243273000855 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 243273000856 CAP-like domain; other site 243273000857 active site 243273000858 primary dimer interface [polypeptide binding]; other site 243273000859 Transcriptional regulator of heat shock gene [Transcription]; Region: HrcA; COG1420 243273000860 excinuclease ABC, C subunit; Region: uvrC; TIGR00194 243273000861 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 243273000862 GIY-YIG motif/motif A; other site 243273000863 active site 243273000864 catalytic site [active] 243273000865 putative DNA binding site [nucleotide binding]; other site 243273000866 metal binding site [ion binding]; metal-binding site 243273000867 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 243273000868 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 243273000869 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 243273000870 active site 243273000871 metal binding site [ion binding]; metal-binding site 243273000872 homotetramer interface [polypeptide binding]; other site 243273000873 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 243273000874 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 243273000875 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 243273000876 RNA binding surface [nucleotide binding]; other site 243273000877 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 243273000878 active site 243273000879 signal peptidase II; Provisional; Region: lspA; PRK00573 243273000880 Ribosomal protein S21 [Translation, ribosomal structure and biogenesis]; Region: RpsU; COG0828 243273000881 DivIVA domain; Region: DivI1A_domain; TIGR03544 243273000882 phosphopantetheine--protein transferase domain; Region: pantethn_trn; TIGR00556 243273000883 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 243273000884 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 243273000885 putative acyl-acceptor binding pocket; other site 243273000886 segregation and condensation protein A/unknown domain fusion protein; Provisional; Region: scpA; PRK00478 243273000887 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 243273000888 segregation and condensation protein B; Region: TIGR00281 243273000889 6-phosphofructokinase; Provisional; Region: PRK03202 243273000890 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 243273000891 active site 243273000892 ADP/pyrophosphate binding site [chemical binding]; other site 243273000893 dimerization interface [polypeptide binding]; other site 243273000894 allosteric effector site; other site 243273000895 fructose-1,6-bisphosphate binding site; other site 243273000896 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 243273000897 pyruvate kinase; Region: pyruv_kin; TIGR01064 243273000898 domain interfaces; other site 243273000899 active site 243273000900 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 243273000901 mraZ protein; Region: TIGR00242 243273000902 MraZ protein; Region: MraZ; pfam02381 243273000903 MraZ protein; Region: MraZ; pfam02381 243273000904 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 243273000905 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 243273000906 cell division protein FtsZ; Region: ftsZ; TIGR00065 243273000907 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 243273000908 nucleotide binding site [chemical binding]; other site 243273000909 SulA interaction site; other site 243273000910 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 243273000911 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 243273000912 thymidylate synthase; Reviewed; Region: thyA; PRK01827 243273000913 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 243273000914 dimerization interface [polypeptide binding]; other site 243273000915 active site 243273000916 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 243273000917 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 243273000918 folate binding site [chemical binding]; other site 243273000919 NADP+ binding site [chemical binding]; other site 243273000920 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 243273000921 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 243273000922 dimer interface [polypeptide binding]; other site 243273000923 putative radical transfer pathway; other site 243273000924 diiron center [ion binding]; other site 243273000925 tyrosyl radical; other site 243273000926 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 243273000927 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07187 243273000928 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 243273000929 Class I ribonucleotide reductase; Region: RNR_I; cd01679 243273000930 active site 243273000931 dimer interface [polypeptide binding]; other site 243273000932 catalytic residues [active] 243273000933 effector binding site; other site 243273000934 R2 peptide binding site; other site 243273000935 ribosomal protein L21; Region: L21; TIGR00061 243273000936 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 243273000937 Ribosomal protein L27 [Translation, ribosomal structure and biogenesis]; Region: RpmA; COG0211 243273000938 AP endonuclease family 2; Region: AP2Ec; smart00518 243273000939 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 243273000940 AP (apurinic/apyrimidinic) site pocket; other site 243273000941 DNA interaction; other site 243273000942 Metal-binding active site; metal-binding site 243273000943 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 243273000944 metal binding site 2 [ion binding]; metal-binding site 243273000945 putative DNA binding helix; other site 243273000946 metal binding site 1 [ion binding]; metal-binding site 243273000947 Protein of unknown function (DUF3196); Region: DUF3196; pfam11428 243273000948 FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones]; Region: Tig; COG0544 243273000949 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 243273000950 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 243273000951 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 243273000952 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243273000953 Walker A motif; other site 243273000954 ATP binding site [chemical binding]; other site 243273000955 Walker B motif; other site 243273000956 arginine finger; other site 243273000957 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 243273000958 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 243273000959 putative nicotinate-nucleotide adenylyltransferase; Validated; Region: nadD; PRK07152 243273000960 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 243273000961 active site 243273000962 (T/H)XGH motif; other site 243273000963 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243273000964 Zn2+ binding site [ion binding]; other site 243273000965 Mg2+ binding site [ion binding]; other site 243273000966 similar to hypothetical proteins found in other bacteria; contains a frameshift 243273000967 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 243273000968 Part of AAA domain; Region: AAA_19; pfam13245 243273000969 Family description; Region: UvrD_C_2; pfam13538 243273000970 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 243273000971 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 243273000972 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 243273000973 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 243273000974 putative active site [active] 243273000975 metal binding site [ion binding]; metal-binding site 243273000976 homodimer binding site [polypeptide binding]; other site 243273000977 acyl-phosphate glycerol 3-phosphate acyltransferase; Region: TIGR00023 243273000978 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 243273000979 Family of unknown function (DUF633); Region: DUF633; pfam04816 243273000980 RNA polymerase sigma factor; Provisional; Region: PRK05901 243273000981 Endoplasmic reticulum-based factor for assembly of V-ATPase; Region: Vma12; pfam11712 243273000982 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 243273000983 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 243273000984 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 243273000985 DNA binding residues [nucleotide binding] 243273000986 DNA primase (bacterial type) [DNA replication, recombination, and repair]; Region: DnaG; COG0358 243273000987 CHC2 zinc finger; Region: zf-CHC2; pfam01807 243273000988 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 243273000989 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 243273000990 active site 243273000991 metal binding site [ion binding]; metal-binding site 243273000992 interdomain interaction site; other site 243273000993 glycyl-tRNA synthetase; Provisional; Region: PRK04173 243273000994 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 243273000995 motif 1; other site 243273000996 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 243273000997 active site 243273000998 motif 2; other site 243273000999 motif 3; other site 243273001000 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 243273001001 anticodon binding site; other site 243273001002 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 243273001003 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 243273001004 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 243273001005 cysteinyl-tRNA synthetase; Region: cysS; TIGR00435 243273001006 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 243273001007 active site 243273001008 HIGH motif; other site 243273001009 nucleotide binding site [chemical binding]; other site 243273001010 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 243273001011 KMSKS motif; other site 243273001012 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 243273001013 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 243273001014 DNA ligase, NAD-dependent; Region: dnlj; TIGR00575 243273001015 nucleotide binding pocket [chemical binding]; other site 243273001016 K-X-D-G motif; other site 243273001017 catalytic site [active] 243273001018 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 243273001019 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 243273001020 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 243273001021 Dimer interface [polypeptide binding]; other site 243273001022 potential protein location (hypothetical protein MG_494 [Mycoplasma genitalium G37]) that overlaps RNA (tRNA-R) 243273001023 Ribosomal protein L31 [Translation, ribosomal structure and biogenesis]; Region: RpmE; COG0254 243273001024 peptide chain release factor 1; Region: prfA; TIGR00019 243273001025 This domain is found in peptide chain release factors; Region: PCRF; smart00937 243273001026 RF-1 domain; Region: RF-1; pfam00472 243273001027 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 243273001028 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243273001029 S-adenosylmethionine binding site [chemical binding]; other site 243273001030 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 243273001031 Mycoplasma MG185/MG260 protein; Region: Lipoprotein_X; pfam03305 243273001032 Putative mycoplasma lipoprotein, C-terminal region; Region: Lipoprotein_10; pfam03202 243273001033 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 243273001034 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 243273001035 active site 243273001036 PHP Thumb interface [polypeptide binding]; other site 243273001037 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 243273001038 5'-3' exonuclease; Provisional; Region: PRK14976 243273001039 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 243273001040 active site 243273001041 metal binding site 1 [ion binding]; metal-binding site 243273001042 putative 5' ssDNA interaction site; other site 243273001043 metal binding site 3; metal-binding site 243273001044 metal binding site 2 [ion binding]; metal-binding site 243273001045 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 243273001046 putative DNA binding site [nucleotide binding]; other site 243273001047 putative metal binding site [ion binding]; other site 243273001048 formamidopyrimidine-DNA glycosylase (fpg); Region: fpg; TIGR00577 243273001049 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 243273001050 DNA binding site [nucleotide binding] 243273001051 catalytic residue [active] 243273001052 H2TH interface [polypeptide binding]; other site 243273001053 putative catalytic residues [active] 243273001054 turnover-facilitating residue; other site 243273001055 intercalation triad [nucleotide binding]; other site 243273001056 8OG recognition residue [nucleotide binding]; other site 243273001057 putative reading head residues; other site 243273001058 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 243273001059 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 243273001060 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 243273001061 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243273001062 active site 243273001063 motif I; other site 243273001064 motif II; other site 243273001065 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 243273001066 dephospho-CoA kinase; Region: TIGR00152 243273001067 CoA-binding site [chemical binding]; other site 243273001068 ATP-binding [chemical binding]; other site 243273001069 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 243273001070 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 243273001071 active site 243273001072 motif I; other site 243273001073 motif II; other site 243273001074 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 243273001075 leucyl-tRNA synthetase, eubacterial and mitochondrial family; Region: leuS_bact; TIGR00396 243273001076 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 243273001077 HIGH motif; other site 243273001078 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 243273001079 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 243273001080 active site 243273001081 KMSKS motif; other site 243273001082 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 243273001083 tRNA binding surface [nucleotide binding]; other site 243273001084 anticodon binding site; other site 243273001085 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 243273001086 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 243273001087 Substrate-binding site [chemical binding]; other site 243273001088 Substrate specificity [chemical binding]; other site 243273001089 phosphodiesterase; Provisional; Region: PRK12704 243273001090 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 243273001091 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 243273001092 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 243273001093 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 243273001094 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 243273001095 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243273001096 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 243273001097 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 243273001098 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 243273001099 E3 interaction surface; other site 243273001100 lipoyl attachment site [posttranslational modification]; other site 243273001101 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 243273001102 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 243273001103 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 243273001104 alpha subunit interface [polypeptide binding]; other site 243273001105 TPP binding site [chemical binding]; other site 243273001106 heterodimer interface [polypeptide binding]; other site 243273001107 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 243273001108 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 243273001109 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 243273001110 tetramer interface [polypeptide binding]; other site 243273001111 TPP-binding site [chemical binding]; other site 243273001112 heterodimer interface [polypeptide binding]; other site 243273001113 phosphorylation loop region [posttranslational modification] 243273001114 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 243273001115 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 243273001116 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 243273001117 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243273001118 active site 243273001119 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 243273001120 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243273001121 Zn2+ binding site [ion binding]; other site 243273001122 Mg2+ binding site [ion binding]; other site 243273001123 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 243273001124 synthetase active site [active] 243273001125 NTP binding site [chemical binding]; other site 243273001126 metal binding site [ion binding]; metal-binding site 243273001127 TIGR03545 family protein; Region: TIGR03545 243273001128 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 243273001129 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 243273001130 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 243273001131 prolyl-tRNA synthetase, family I; Region: proS_fam_I; TIGR00408 243273001132 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 243273001133 dimer interface [polypeptide binding]; other site 243273001134 motif 1; other site 243273001135 active site 243273001136 motif 2; other site 243273001137 motif 3; other site 243273001138 Anticodon binding domain; Region: HGTP_anticodon; pfam03129 243273001139 Prolyl-tRNA synthetase, C-terminal; Region: ProRS-C_1; smart00946 243273001140 acyl carrier protein; Validated; Region: PRK05828 243273001141 similar to hypothetical proteins found in other bacteria; reportedly expressed in PMID: 10712586; contains a frameshift 243273001142 High affinity transport system protein p37; Region: Mycoplasma_p37; pfam06646 243273001143 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 243273001144 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 243273001145 Walker A/P-loop; other site 243273001146 ATP binding site [chemical binding]; other site 243273001147 Q-loop/lid; other site 243273001148 ABC transporter signature motif; other site 243273001149 Walker B; other site 243273001150 D-loop; other site 243273001151 H-loop/switch region; other site 243273001152 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 243273001153 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 243273001154 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 243273001155 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 243273001156 alanine--tRNA ligase; Region: alaS; TIGR00344 243273001157 motif 1; other site 243273001158 active site 243273001159 motif 2; other site 243273001160 motif 3; other site 243273001161 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 243273001162 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 243273001163 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 243273001164 active site 243273001165 catalytic site [active] 243273001166 metal binding site [ion binding]; metal-binding site 243273001167 dimer interface [polypeptide binding]; other site 243273001168 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 243273001169 putative substrate translocation pore; other site 243273001170 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 243273001171 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 243273001172 Ligand Binding Site [chemical binding]; other site 243273001173 Mg296 protein; Region: Mg296; pfam09644 243273001174 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 243273001175 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 243273001176 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 243273001177 P loop; other site 243273001178 GTP binding site [chemical binding]; other site 243273001179 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 243273001180 AAA domain; Region: AAA_23; pfam13476 243273001181 Walker A/P-loop; other site 243273001182 ATP binding site [chemical binding]; other site 243273001183 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 243273001184 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 243273001185 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 243273001186 ABC transporter signature motif; other site 243273001187 Walker B; other site 243273001188 D-loop; other site 243273001189 H-loop/switch region; other site 243273001190 phosphate acetyltransferase; Region: pta; TIGR00651 243273001191 3-phosphoglycerate kinase [Carbohydrate transport and metabolism]; Region: Pgk; COG0126 243273001192 Phosphoglycerate kinase; Region: PGK; pfam00162 243273001193 substrate binding site [chemical binding]; other site 243273001194 hinge regions; other site 243273001195 ADP binding site [chemical binding]; other site 243273001196 catalytic site [active] 243273001197 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 243273001198 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 243273001199 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 243273001200 Cobalt transport protein; Region: CbiQ; pfam02361 243273001201 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 243273001202 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 243273001203 Walker A/P-loop; other site 243273001204 ATP binding site [chemical binding]; other site 243273001205 Q-loop/lid; other site 243273001206 ABC transporter signature motif; other site 243273001207 Walker B; other site 243273001208 D-loop; other site 243273001209 H-loop/switch region; other site 243273001210 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 243273001211 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 243273001212 Walker A/P-loop; other site 243273001213 ATP binding site [chemical binding]; other site 243273001214 Q-loop/lid; other site 243273001215 ABC transporter signature motif; other site 243273001216 Walker B; other site 243273001217 D-loop; other site 243273001218 H-loop/switch region; other site 243273001219 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 243273001220 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 243273001221 nucleotide binding site [chemical binding]; other site 243273001222 NEF interaction site [polypeptide binding]; other site 243273001223 SBD interface [polypeptide binding]; other site 243273001224 Predicted integral membrane protein [Function unknown]; Region: COG0392 243273001225 Protein of unknown function (DUF3713); Region: DUF3713; pfam12506 243273001226 DEAD-like helicases superfamily; Region: DEXDc; smart00487 243273001227 DEAD/DEAH box helicase; Region: DEAD; pfam00270 243273001228 ATP binding site [chemical binding]; other site 243273001229 putative Mg++ binding site [ion binding]; other site 243273001230 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243273001231 nucleotide binding region [chemical binding]; other site 243273001232 ATP-binding site [chemical binding]; other site 243273001233 Protein of unknown function (DUF3713); Region: DUF3713; pfam12506 243273001234 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 243273001235 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 243273001236 ribosomal protein S4, bacterial/organelle type; Region: rpsD_bact; TIGR01017 243273001237 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 243273001238 RNA binding surface [nucleotide binding]; other site 243273001239 cytadherence high molecular weight protein 1 N-terminal region; Region: termin_org_HMW1; TIGR03836 243273001240 EAGR box; Region: EAGR_box; TIGR03834 243273001241 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 243273001242 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 243273001243 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 243273001244 ComEC/Rec2-related protein; Region: ComEC_N-term; TIGR00360 243273001245 cell division protein ZipA; Provisional; Region: PRK03427 243273001246 ribonuclease E; Reviewed; Region: rne; PRK10811 243273001247 Cytadhesin P30/P32; Region: Cytadhesin_P30; pfam07271 243273001248 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 243273001249 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 243273001250 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 243273001251 TrkA-N domain; Region: TrkA_N; pfam02254 243273001252 TrkA-C domain; Region: TrkA_C; pfam02080 243273001253 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 243273001254 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 243273001255 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 243273001256 active site 243273001257 ribosomal protein L33, bacterial type; Region: rpmG_bact; TIGR01023 243273001258 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 243273001259 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 243273001260 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 243273001261 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 243273001262 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 243273001263 nucleophilic elbow; other site 243273001264 catalytic site [active] 243273001265 catalytic triad; other site 243273001266 V-type ATP synthase subunit I; Validated; Region: PRK05771 243273001267 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 243273001268 Predicted GTPases [General function prediction only]; Region: COG1160 243273001269 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 243273001270 G1 box; other site 243273001271 GTP/Mg2+ binding site [chemical binding]; other site 243273001272 Switch I region; other site 243273001273 G2 box; other site 243273001274 Switch II region; other site 243273001275 G3 box; other site 243273001276 G4 box; other site 243273001277 G5 box; other site 243273001278 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 243273001279 G1 box; other site 243273001280 GTP/Mg2+ binding site [chemical binding]; other site 243273001281 Switch I region; other site 243273001282 G2 box; other site 243273001283 G3 box; other site 243273001284 Switch II region; other site 243273001285 G4 box; other site 243273001286 G5 box; other site 243273001287 cytidylate kinase; Region: cmk; TIGR00017 243273001288 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 243273001289 CMP-binding site; other site 243273001290 The sites determining sugar specificity; other site 243273001291 DNA-binding regulatory protein, YebC/PmpR family; Region: TIGR01033 243273001292 valyl-tRNA synthetase; Region: valS; TIGR00422 243273001293 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 243273001294 active site 243273001295 HIGH motif; other site 243273001296 nucleotide binding site [chemical binding]; other site 243273001297 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 243273001298 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 243273001299 active site 243273001300 KMSKS motif; other site 243273001301 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 243273001302 tRNA binding surface [nucleotide binding]; other site 243273001303 anticodon binding site; other site 243273001304 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 243273001305 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 243273001306 G1 box; other site 243273001307 GTP/Mg2+ binding site [chemical binding]; other site 243273001308 Switch I region; other site 243273001309 G2 box; other site 243273001310 G3 box; other site 243273001311 Switch II region; other site 243273001312 G4 box; other site 243273001313 G5 box; other site 243273001314 hypothetical protein; Provisional; Region: PRK00523 243273001315 putative glycosyl transferase; Provisional; Region: PRK10073 243273001316 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 243273001317 active site 243273001318 Aminotransferase class-V; Region: Aminotran_5; pfam00266 243273001319 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 243273001320 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 243273001321 catalytic residue [active] 243273001322 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 243273001323 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 243273001324 trimerization site [polypeptide binding]; other site 243273001325 active site 243273001326 Protein of unknown function (DUF3713); Region: DUF3713; pfam12506 243273001327 recombinase A; Provisional; Region: recA; PRK09354 243273001328 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 243273001329 Walker A motif; other site 243273001330 ATP binding site [chemical binding]; other site 243273001331 Walker B motif; other site 243273001332 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 243273001333 DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386 243273001334 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 243273001335 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 243273001336 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 243273001337 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 243273001338 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 243273001339 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 243273001340 G-loop; other site 243273001341 DNA binding site [nucleotide binding] 243273001342 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 243273001343 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 243273001344 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 243273001345 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 243273001346 RPB10 interaction site [polypeptide binding]; other site 243273001347 RPB11 interaction site [polypeptide binding]; other site 243273001348 RPB3 interaction site [polypeptide binding]; other site 243273001349 RPB12 interaction site [polypeptide binding]; other site 243273001350 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 243273001351 RPB1 interaction site [polypeptide binding]; other site 243273001352 Predicted flavoprotein [General function prediction only]; Region: COG0431 243273001353 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 243273001354 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 243273001355 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 243273001356 nucleophilic elbow; other site 243273001357 catalytic triad; other site 243273001358 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 243273001359 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 243273001360 active site 243273001361 HIGH motif; other site 243273001362 nucleotide binding site [chemical binding]; other site 243273001363 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 243273001364 active site 243273001365 KMSKS motif; other site 243273001366 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 243273001367 tRNA binding surface [nucleotide binding]; other site 243273001368 anticodon binding site; other site 243273001369 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 243273001370 tRNA (cytidine(34)-2'-O)-methyltransferase; Region: tRNA_yibK_trmL; TIGR00185 243273001371 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 243273001372 S-adenosylmethionine binding site [chemical binding]; other site 243273001373 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 243273001374 inorganic pyrophosphatase; Provisional; Region: PRK02230 243273001375 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 243273001376 dimer interface [polypeptide binding]; other site 243273001377 substrate binding site [chemical binding]; other site 243273001378 metal binding sites [ion binding]; metal-binding site 243273001379 recombination protein U; Region: recU; TIGR00648 243273001380 Bacterial nucleoid DNA-binding protein [DNA replication, recombination, and repair]; Region: HimA; COG0776 243273001381 IHF - DNA interface [nucleotide binding]; other site 243273001382 Domain of unknown function (DUF1951); Region: DUF1951; pfam09188 243273001383 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243273001384 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 243273001385 Walker A motif; other site 243273001386 ATP binding site [chemical binding]; other site 243273001387 Walker B motif; other site 243273001388 arginine finger; other site 243273001389 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243273001390 Walker A motif; other site 243273001391 ATP binding site [chemical binding]; other site 243273001392 Walker B motif; other site 243273001393 arginine finger; other site 243273001394 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 243273001395 Thiamine kinase and related kinases [Coenzyme transport and metabolism]; Region: ycfN; COG0510 243273001396 Phosphotransferase enzyme family; Region: APH; pfam01636 243273001397 active site 243273001398 substrate binding site [chemical binding]; other site 243273001399 ATP binding site [chemical binding]; other site 243273001400 acetate kinase; Region: ackA; TIGR00016 243273001401 propionate/acetate kinase; Provisional; Region: PRK12379 243273001402 Holliday junction DNA helicase, RuvA subunit; Region: ruvA; TIGR00084 243273001403 RuvA N terminal domain; Region: RuvA_N; pfam01330 243273001404 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 243273001405 Holliday junction DNA helicase, RuvB subunit; Region: ruvB; TIGR00635 243273001406 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243273001407 Walker A motif; other site 243273001408 ATP binding site [chemical binding]; other site 243273001409 Walker B motif; other site 243273001410 arginine finger; other site 243273001411 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 243273001412 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 243273001413 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 243273001414 active site 243273001415 DNA binding site [nucleotide binding] 243273001416 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 243273001417 23S rRNA interface [nucleotide binding]; other site 243273001418 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 243273001419 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 243273001420 core dimer interface [polypeptide binding]; other site 243273001421 peripheral dimer interface [polypeptide binding]; other site 243273001422 L10 interface [polypeptide binding]; other site 243273001423 L11 interface [polypeptide binding]; other site 243273001424 putative EF-Tu interaction site [polypeptide binding]; other site 243273001425 putative EF-G interaction site [polypeptide binding]; other site 243273001426 Ribosomal protein L32 [Translation, ribosomal structure and biogenesis]; Region: RpmF; COG0333 243273001427 Ribosomal protein S20 [Translation, ribosomal structure and biogenesis]; Region: RpsT; COG0268 243273001428 methionyl-tRNA formyltransferase; Region: fmt; TIGR00460 243273001429 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 243273001430 putative active site [active] 243273001431 substrate binding site [chemical binding]; other site 243273001432 putative cosubstrate binding site; other site 243273001433 catalytic site [active] 243273001434 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 243273001435 substrate binding site [chemical binding]; other site 243273001436 Domain of unknown function(DUF2779); Region: DUF2779; pfam11074 243273001437 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 243273001438 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 243273001439 dimerization interface [polypeptide binding]; other site 243273001440 active site 243273001441 metal binding site [ion binding]; metal-binding site 243273001442 fatty acid/phospholipid synthesis protein PlsX; Region: plsX; TIGR00182 243273001443 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 243273001444 DAK2 domain; Region: Dak2; pfam02734 243273001445 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 243273001446 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 243273001447 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 243273001448 active site 243273001449 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 243273001450 DHH family; Region: DHH; pfam01368 243273001451 DHHA1 domain; Region: DHHA1; pfam02272 243273001452 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 243273001453 tRNA sulfurtransferase ThiI; Region: TIGR00342 243273001454 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 243273001455 Ligand Binding Site [chemical binding]; other site 243273001456 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 243273001457 threonyl-tRNA synthetase; Region: thrS; TIGR00418 243273001458 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 243273001459 active site 243273001460 dimer interface [polypeptide binding]; other site 243273001461 motif 1; other site 243273001462 motif 2; other site 243273001463 motif 3; other site 243273001464 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 243273001465 anticodon binding site; other site 243273001466 Protein of unknown function (DUF3217); Region: DUF3217; pfam11506 243273001467 arginyl-tRNA synthetase; Region: argS; TIGR00456 243273001468 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 243273001469 active site 243273001470 HIGH motif; other site 243273001471 KMSK motif region; other site 243273001472 tRNA binding surface [nucleotide binding]; other site 243273001473 DALR anticodon binding domain; Region: DALR_1; smart00836 243273001474 anticodon binding site; other site 243273001475 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 243273001476 glucose-inhibited division protein A; Region: gidA; TIGR00136 243273001477 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 243273001478 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 243273001479 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 243273001480 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 243273001481 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 243273001482 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 243273001483 ATP-binding site [chemical binding]; other site 243273001484 Sugar specificity; other site 243273001485 Pyrimidine base specificity; other site 243273001486 NAD+ synthetase; Region: nadE; TIGR00552 243273001487 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 243273001488 homodimer interface [polypeptide binding]; other site 243273001489 NAD binding pocket [chemical binding]; other site 243273001490 ATP binding pocket [chemical binding]; other site 243273001491 Mg binding site [ion binding]; other site 243273001492 active-site loop [active] 243273001493 GTP1/OBG; Region: GTP1_OBG; pfam01018 243273001494 GTPase CgtA; Reviewed; Region: obgE; PRK12297 243273001495 Obg GTPase; Region: Obg; cd01898 243273001496 G1 box; other site 243273001497 GTP/Mg2+ binding site [chemical binding]; other site 243273001498 Switch I region; other site 243273001499 G2 box; other site 243273001500 G3 box; other site 243273001501 Switch II region; other site 243273001502 G4 box; other site 243273001503 G5 box; other site 243273001504 Obg family GTPase CgtA, C-terminal extension; Region: Obg_CgtA_exten; TIGR03595 243273001505 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 243273001506 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 243273001507 active site 243273001508 catalytic site [active] 243273001509 EAGR box; Region: EAGR_box; TIGR03834 243273001510 EAGR box; Region: EAGR_box; TIGR03834 243273001511 EAGR box; Region: EAGR_box; TIGR03834 243273001512 EAGR box; Region: EAGR_box; TIGR03834 243273001513 GTP-binding protein Era; Region: era; TIGR00436 243273001514 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 243273001515 G1 box; other site 243273001516 GTP/Mg2+ binding site [chemical binding]; other site 243273001517 Switch I region; other site 243273001518 G2 box; other site 243273001519 Switch II region; other site 243273001520 G3 box; other site 243273001521 G4 box; other site 243273001522 G5 box; other site 243273001523 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 243273001524 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 243273001525 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 243273001526 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39E; cd02424 243273001527 putative active site [active] 243273001528 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 243273001529 Walker A/P-loop; other site 243273001530 ATP binding site [chemical binding]; other site 243273001531 Q-loop/lid; other site 243273001532 ABC transporter signature motif; other site 243273001533 Walker B; other site 243273001534 D-loop; other site 243273001535 H-loop/switch region; other site 243273001536 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 243273001537 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 243273001538 interface (dimer of trimers) [polypeptide binding]; other site 243273001539 Substrate-binding/catalytic site; other site 243273001540 Zn-binding sites [ion binding]; other site 243273001541 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 243273001542 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 243273001543 ring oligomerisation interface [polypeptide binding]; other site 243273001544 ATP/Mg binding site [chemical binding]; other site 243273001545 stacking interactions; other site 243273001546 hinge regions; other site 243273001547 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 243273001548 oligomerisation interface [polypeptide binding]; other site 243273001549 mobile loop; other site 243273001550 roof hairpin; other site 243273001551 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 243273001552 dimer interface [polypeptide binding]; other site 243273001553 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 243273001554 active site 243273001555 glycine-pyridoxal phosphate binding site [chemical binding]; other site 243273001556 folate binding site [chemical binding]; other site 243273001557 Putative peptidase (DUF31); Region: DUF31; pfam01732 243273001558 sugar-phosphate isomerase, RpiB/LacA/LacB family; Region: rpiB_lacA_lacB; TIGR00689 243273001559 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 243273001560 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00539 243273001561 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 243273001562 gamma subunit interface [polypeptide binding]; other site 243273001563 epsilon subunit interface [polypeptide binding]; other site 243273001564 LBP interface [polypeptide binding]; other site 243273001565 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 243273001566 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 243273001567 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 243273001568 alpha subunit interaction interface [polypeptide binding]; other site 243273001569 Walker A motif; other site 243273001570 ATP binding site [chemical binding]; other site 243273001571 Walker B motif; other site 243273001572 inhibitor binding site; inhibition site 243273001573 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 243273001574 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 243273001575 core domain interface [polypeptide binding]; other site 243273001576 delta subunit interface [polypeptide binding]; other site 243273001577 epsilon subunit interface [polypeptide binding]; other site 243273001578 proton translocating ATP synthase, F1 alpha subunit; Region: atpA; TIGR00962 243273001579 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 243273001580 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 243273001581 beta subunit interaction interface [polypeptide binding]; other site 243273001582 Walker A motif; other site 243273001583 ATP binding site [chemical binding]; other site 243273001584 Walker B motif; other site 243273001585 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 243273001586 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; COG0712 243273001587 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 243273001588 F0F1 ATP synthase subunit B; Validated; Region: PRK06231 243273001589 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 243273001590 F0F1 ATP synthase subunit C; Validated; Region: PRK07159 243273001591 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 243273001592 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 243273001593 enolase; Provisional; Region: eno; PRK00077 243273001594 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 243273001595 dimer interface [polypeptide binding]; other site 243273001596 metal binding site [ion binding]; metal-binding site 243273001597 substrate binding pocket [chemical binding]; other site 243273001598 methionine sulfoxide reductase A; Provisional; Region: PRK14054 243273001599 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 243273001600 PhoU domain; Region: PhoU; pfam01895 243273001601 PhoU domain; Region: PhoU; pfam01895 243273001602 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 243273001603 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 243273001604 Walker A/P-loop; other site 243273001605 ATP binding site [chemical binding]; other site 243273001606 Q-loop/lid; other site 243273001607 ABC transporter signature motif; other site 243273001608 Walker B; other site 243273001609 D-loop; other site 243273001610 H-loop/switch region; other site 243273001611 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 243273001612 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243273001613 dimer interface [polypeptide binding]; other site 243273001614 conserved gate region; other site 243273001615 putative PBP binding loops; other site 243273001616 ABC-ATPase subunit interface; other site 243273001617 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 243273001618 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 243273001619 dimer interface [polypeptide binding]; other site 243273001620 conserved gate region; other site 243273001621 putative PBP binding loops; other site 243273001622 ABC-ATPase subunit interface; other site 243273001623 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 243273001624 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 243273001625 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 243273001626 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 243273001627 23S rRNA interface [nucleotide binding]; other site 243273001628 L3 interface [polypeptide binding]; other site 243273001629 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05896 243273001630 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243273001631 Walker A motif; other site 243273001632 ATP binding site [chemical binding]; other site 243273001633 Walker B motif; other site 243273001634 arginine finger; other site 243273001635 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 243273001636 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 243273001637 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 243273001638 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 243273001639 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 243273001640 conserved hypothetical protein; Region: MG423; TIGR00649 243273001641 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 243273001642 16S/18S rRNA binding site [nucleotide binding]; other site 243273001643 S13e-L30e interaction site [polypeptide binding]; other site 243273001644 25S rRNA binding site [nucleotide binding]; other site 243273001645 helicase 45; Provisional; Region: PTZ00424 243273001646 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 243273001647 ATP binding site [chemical binding]; other site 243273001648 Mg++ binding site [ion binding]; other site 243273001649 motif III; other site 243273001650 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 243273001651 nucleotide binding region [chemical binding]; other site 243273001652 ATP-binding site [chemical binding]; other site 243273001653 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 243273001654 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 243273001655 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 243273001656 DNA binding residues [nucleotide binding] 243273001657 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 243273001658 phosphoenolpyruvate-protein phosphotransferase; Region: PTS_I_fam; TIGR01417 243273001659 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 243273001660 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 243273001661 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 243273001662 phosphoglyceromutase; Provisional; Region: PRK05434 243273001663 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 243273001664 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 243273001665 triosephosphate isomerase; Provisional; Region: PRK14567 243273001666 substrate binding site [chemical binding]; other site 243273001667 dimer interface [polypeptide binding]; other site 243273001668 catalytic triad [active] 243273001669 Uncharacterized conserved protein [Function unknown]; Region: COG1284 243273001670 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 243273001671 translation elongation factor Ts; Region: tsf; TIGR00116 243273001672 UBA/TS-N domain; Region: UBA; pfam00627 243273001673 Elongation factor TS; Region: EF_TS; pfam00889 243273001674 Elongation factor TS; Region: EF_TS; pfam00889 243273001675 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 243273001676 putative nucleotide binding site [chemical binding]; other site 243273001677 uridine monophosphate binding site [chemical binding]; other site 243273001678 homohexameric interface [polypeptide binding]; other site 243273001679 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 243273001680 ribosome recycling factor; Reviewed; Region: frr; PRK00083 243273001681 hinge region; other site 243273001682 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 243273001683 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 243273001684 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 243273001685 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 243273001686 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 243273001687 Lipoprotein; Region: Lipoprotein_3; pfam00938 243273001688 Lipoprotein; Region: Lipoprotein_3; pfam00938 243273001689 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 243273001690 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 243273001691 GTP/Mg2+ binding site [chemical binding]; other site 243273001692 G4 box; other site 243273001693 G5 box; other site 243273001694 G1 box; other site 243273001695 Switch I region; other site 243273001696 G2 box; other site 243273001697 G3 box; other site 243273001698 Switch II region; other site 243273001699 Uncharacterized conserved protein [Function unknown]; Region: COG1284 243273001700 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 243273001701 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 243273001702 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 243273001703 tRNA (guanine-N1)-methyltransferase; Region: trmD; TIGR00088 243273001704 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 243273001705 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 243273001706 putative efflux protein, MATE family; Region: matE; TIGR00797 243273001707 methionine-R-sulfoxide reductase; Region: TIGR00357 243273001708 SelR domain; Region: SelR; pfam01641 243273001709 similar to hypothetical proteins from other bacteria; contains a frameshift 243273001710 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 243273001711 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 243273001712 elongation factor Tu; Reviewed; Region: PRK00049 243273001713 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 243273001714 G1 box; other site 243273001715 GEF interaction site [polypeptide binding]; other site 243273001716 GTP/Mg2+ binding site [chemical binding]; other site 243273001717 Switch I region; other site 243273001718 G2 box; other site 243273001719 G3 box; other site 243273001720 Switch II region; other site 243273001721 G4 box; other site 243273001722 G5 box; other site 243273001723 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 243273001724 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 243273001725 Antibiotic Binding Site [chemical binding]; other site 243273001726 Protein of unknown function (DUF1600); Region: DUF1600; pfam07667 243273001727 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 243273001728 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 243273001729 active site 243273001730 tetramer interface; other site 243273001731 Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism]; Region: osmC; COG1764 243273001732 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 243273001733 tRNA synthetases class I (W and Y); Region: tRNA-synt_1b; pfam00579 243273001734 active site 243273001735 nucleotide binding site [chemical binding]; other site 243273001736 HIGH motif; other site 243273001737 KMSKS motif; other site 243273001738 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 243273001739 RNA binding surface [nucleotide binding]; other site 243273001740 Protein of unknown function (DUF3098); Region: DUF3098; pfam11297 243273001741 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 243273001742 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243273001743 Walker A motif; other site 243273001744 ATP binding site [chemical binding]; other site 243273001745 Walker B motif; other site 243273001746 arginine finger; other site 243273001747 Peptidase family M41; Region: Peptidase_M41; pfam01434 243273001748 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 243273001749 active site 243273001750 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 243273001751 homotrimer interaction site [polypeptide binding]; other site 243273001752 zinc binding site [ion binding]; other site 243273001753 CDP-binding sites; other site 243273001754 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 243273001755 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 243273001756 NAD binding site [chemical binding]; other site 243273001757 dimer interface [polypeptide binding]; other site 243273001758 tetramer (dimer of dimers) interface [polypeptide binding]; other site 243273001759 substrate binding site [chemical binding]; other site 243273001760 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 243273001761 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 243273001762 Zn2+ binding site [ion binding]; other site 243273001763 Mg2+ binding site [ion binding]; other site 243273001764 glutamyl-tRNA synthetase, bacterial family; Region: gltX_bact; TIGR00464 243273001765 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 243273001766 HIGH motif; other site 243273001767 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 243273001768 active site 243273001769 KMSKS motif; other site 243273001770 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 243273001771 dimethyladenosine transferase; Region: ksgA; TIGR00755 243273001772 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02201 243273001773 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 243273001774 ribonuclease P protein component, eubacterial; Region: rnpA; TIGR00188 243273001775 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 243273001776 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 243273001777 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 243273001778 Walker A/P-loop; other site 243273001779 ATP binding site [chemical binding]; other site 243273001780 Q-loop/lid; other site 243273001781 ABC transporter signature motif; other site 243273001782 Walker B; other site 243273001783 D-loop; other site 243273001784 H-loop/switch region; other site 243273001785 FtsX-like permease family; Region: FtsX; pfam02687 243273001786 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 243273001787 FtsX-like permease family; Region: FtsX; pfam02687 243273001788 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 243273001789 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 243273001790 Walker A/P-loop; other site 243273001791 ATP binding site [chemical binding]; other site 243273001792 Q-loop/lid; other site 243273001793 ABC transporter signature motif; other site 243273001794 Walker B; other site 243273001795 D-loop; other site 243273001796 H-loop/switch region; other site 243273001797 DnaA N-terminal domain; Region: DnaA_N; pfam11638 243273001798 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 243273001799 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 243273001800 Walker A motif; other site 243273001801 ATP binding site [chemical binding]; other site 243273001802 Walker B motif; other site 243273001803 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 243273001804 DnaA box-binding interface [nucleotide binding]; other site 243273001805 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 243273001806 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 243273001807 P-loop; other site 243273001808 Magnesium ion binding site [ion binding]; other site 243273001809 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 243273001810 Magnesium ion binding site [ion binding]; other site