-- dump date 20140619_161024 -- class Genbank::misc_feature -- table misc_feature_note -- id note 262719000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 262719000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 262719000003 Walker A motif; other site 262719000004 ATP binding site [chemical binding]; other site 262719000005 Walker B motif; other site 262719000006 arginine finger; other site 262719000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 262719000008 DnaA box-binding interface [nucleotide binding]; other site 262719000009 DNA polymerase III subunit beta; Provisional; Region: PRK14946 262719000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 262719000011 putative DNA binding surface [nucleotide binding]; other site 262719000012 dimer interface [polypeptide binding]; other site 262719000013 beta-clamp/clamp loader binding surface; other site 262719000014 beta-clamp/translesion DNA polymerase binding surface; other site 262719000015 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 262719000016 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 262719000017 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 262719000018 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679 262719000019 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 262719000020 DHH family; Region: DHH; pfam01368 262719000021 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 262719000022 DHH family; Region: DHH; pfam01368 262719000023 DHHA1 domain; Region: DHHA1; pfam02272 262719000024 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 262719000025 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 262719000026 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 262719000027 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 262719000028 P loop; other site 262719000029 GTP binding site [chemical binding]; other site 262719000030 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 262719000031 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 262719000032 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 262719000033 catalytic residues [active] 262719000034 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 262719000035 GrpE; Region: GrpE; pfam01025 262719000036 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 262719000037 dimer interface [polypeptide binding]; other site 262719000038 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 262719000039 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 262719000040 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 262719000041 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 262719000042 active site 262719000043 HIGH motif; other site 262719000044 KMSK motif region; other site 262719000045 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 262719000046 tRNA binding surface [nucleotide binding]; other site 262719000047 anticodon binding site; other site 262719000048 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319 262719000049 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 262719000050 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 262719000051 intersubunit interface [polypeptide binding]; other site 262719000052 active site 262719000053 zinc binding site [ion binding]; other site 262719000054 Na+ binding site [ion binding]; other site 262719000055 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 262719000056 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 262719000057 active site 262719000058 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262719000059 Q-loop/lid; other site 262719000060 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 262719000061 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262719000062 Walker A/P-loop; other site 262719000063 ATP binding site [chemical binding]; other site 262719000064 Q-loop/lid; other site 262719000065 ABC transporter signature motif; other site 262719000066 Walker B; other site 262719000067 D-loop; other site 262719000068 H-loop/switch region; other site 262719000069 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 262719000070 FtsX-like permease family; Region: FtsX; pfam02687 262719000071 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 262719000072 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262719000073 Walker A/P-loop; other site 262719000074 ATP binding site [chemical binding]; other site 262719000075 Q-loop/lid; other site 262719000076 ABC transporter signature motif; other site 262719000077 Walker B; other site 262719000078 D-loop; other site 262719000079 H-loop/switch region; other site 262719000080 FtsX-like permease family; Region: FtsX; pfam02687 262719000081 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 262719000082 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262719000083 Walker A/P-loop; other site 262719000084 ATP binding site [chemical binding]; other site 262719000085 Q-loop/lid; other site 262719000086 ABC transporter signature motif; other site 262719000087 Walker B; other site 262719000088 D-loop; other site 262719000089 H-loop/switch region; other site 262719000090 FtsX-like permease family; Region: FtsX; pfam02687 262719000091 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 262719000092 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 262719000093 Catalytic site [active] 262719000094 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 262719000095 amidase; Provisional; Region: PRK07139 262719000096 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 262719000097 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 262719000098 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 262719000099 GatB domain; Region: GatB_Yqey; smart00845 262719000100 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 262719000101 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 262719000102 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 262719000103 active site 262719000104 HIGH motif; other site 262719000105 nucleotide binding site [chemical binding]; other site 262719000106 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 262719000107 active site 262719000108 KMSKS motif; other site 262719000109 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 262719000110 tRNA binding surface [nucleotide binding]; other site 262719000111 anticodon binding site; other site 262719000112 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 262719000113 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 262719000114 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 262719000115 CAP-like domain; other site 262719000116 active site 262719000117 primary dimer interface [polypeptide binding]; other site 262719000118 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 262719000119 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit [DNA replication, recombination, and repair]; Region: GyrB; COG0187 262719000120 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262719000121 ATP binding site [chemical binding]; other site 262719000122 Mg2+ binding site [ion binding]; other site 262719000123 G-X-G motif; other site 262719000124 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 262719000125 anchoring element; other site 262719000126 dimer interface [polypeptide binding]; other site 262719000127 ATP binding site [chemical binding]; other site 262719000128 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 262719000129 active site 262719000130 putative metal-binding site [ion binding]; other site 262719000131 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 262719000132 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 262719000133 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 262719000134 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 262719000135 ribonuclease R; Region: RNase_R; TIGR02063 262719000136 RNB domain; Region: RNB; pfam00773 262719000137 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 262719000138 RNA binding site [nucleotide binding]; other site 262719000139 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 262719000140 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 262719000141 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 262719000142 putative active site [active] 262719000143 catalytic site [active] 262719000144 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 262719000145 putative active site [active] 262719000146 catalytic site [active] 262719000147 recombinase A; Provisional; Region: recA; PRK09354 262719000148 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 262719000149 hexamer interface [polypeptide binding]; other site 262719000150 Walker A motif; other site 262719000151 ATP binding site [chemical binding]; other site 262719000152 Walker B motif; other site 262719000153 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 262719000154 active site 262719000155 substrate binding site [chemical binding]; other site 262719000156 ATP binding site [chemical binding]; other site 262719000157 GTPase CgtA; Reviewed; Region: obgE; PRK12297 262719000158 GTP1/OBG; Region: GTP1_OBG; pfam01018 262719000159 Obg GTPase; Region: Obg; cd01898 262719000160 G1 box; other site 262719000161 GTP/Mg2+ binding site [chemical binding]; other site 262719000162 Switch I region; other site 262719000163 G2 box; other site 262719000164 G3 box; other site 262719000165 Switch II region; other site 262719000166 G4 box; other site 262719000167 G5 box; other site 262719000168 Obg family GTPase CgtA, C-terminal extension; Region: Obg_CgtA_exten; TIGR03595 262719000169 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 262719000170 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 262719000171 active site 262719000172 DNA binding site [nucleotide binding] 262719000173 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 262719000174 F0F1 ATP synthase subunit C; Validated; Region: PRK07159 262719000175 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 262719000176 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13436 262719000177 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 262719000178 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 262719000179 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 262719000180 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 262719000181 beta subunit interaction interface [polypeptide binding]; other site 262719000182 Walker A motif; other site 262719000183 ATP binding site [chemical binding]; other site 262719000184 Walker B motif; other site 262719000185 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 262719000186 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 262719000187 core domain interface [polypeptide binding]; other site 262719000188 delta subunit interface [polypeptide binding]; other site 262719000189 epsilon subunit interface [polypeptide binding]; other site 262719000190 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 262719000191 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 262719000192 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 262719000193 alpha subunit interaction interface [polypeptide binding]; other site 262719000194 Walker A motif; other site 262719000195 ATP binding site [chemical binding]; other site 262719000196 Walker B motif; other site 262719000197 inhibitor binding site; inhibition site 262719000198 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 262719000199 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 262719000200 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 262719000201 rRNA interaction site [nucleotide binding]; other site 262719000202 S8 interaction site; other site 262719000203 putative laminin-1 binding site; other site 262719000204 elongation factor Ts; Provisional; Region: tsf; PRK09377 262719000205 UBA/TS-N domain; Region: UBA; pfam00627 262719000206 Elongation factor TS; Region: EF_TS; pfam00889 262719000207 Elongation factor TS; Region: EF_TS; pfam00889 262719000208 signal recognition particle protein; Provisional; Region: PRK10867 262719000209 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 262719000210 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 262719000211 P loop; other site 262719000212 GTP binding site [chemical binding]; other site 262719000213 Signal peptide binding domain; Region: SRP_SPB; pfam02978 262719000214 glycyl-tRNA synthetase; Provisional; Region: PRK04173 262719000215 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 262719000216 motif 1; other site 262719000217 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 262719000218 active site 262719000219 motif 2; other site 262719000220 motif 3; other site 262719000221 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 262719000222 anticodon binding site; other site 262719000223 DNA primase, catalytic core; Region: dnaG; TIGR01391 262719000224 CHC2 zinc finger; Region: zf-CHC2; cl17510 262719000225 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 262719000226 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 262719000227 active site 262719000228 metal binding site [ion binding]; metal-binding site 262719000229 interdomain interaction site; other site 262719000230 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 262719000231 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 262719000232 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 262719000233 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 262719000234 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 262719000235 DNA binding residues [nucleotide binding] 262719000236 Uncharacterized conserved protein [Function unknown]; Region: COG0327 262719000237 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 262719000238 endonuclease IV; Provisional; Region: PRK01060 262719000239 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 262719000240 AP (apurinic/apyrimidinic) site pocket; other site 262719000241 DNA interaction; other site 262719000242 Metal-binding active site; metal-binding site 262719000243 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 262719000244 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 262719000245 active site 262719000246 HIGH motif; other site 262719000247 dimer interface [polypeptide binding]; other site 262719000248 KMSKS motif; other site 262719000249 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 262719000250 AAA domain; Region: AAA_11; pfam13086 262719000251 Part of AAA domain; Region: AAA_19; pfam13245 262719000252 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 262719000253 AAA domain; Region: AAA_12; pfam13087 262719000254 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 262719000255 putative active site [active] 262719000256 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 262719000257 active site 262719000258 catalytic triad [active] 262719000259 excinuclease ABC, C subunit; Region: uvrC; TIGR00194 262719000260 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 262719000261 GIY-YIG motif/motif A; other site 262719000262 active site 262719000263 catalytic site [active] 262719000264 putative DNA binding site [nucleotide binding]; other site 262719000265 metal binding site [ion binding]; metal-binding site 262719000266 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 262719000267 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 262719000268 chaperone protein DnaK; Region: prok_dnaK; TIGR02350 262719000269 nucleotide binding site [chemical binding]; other site 262719000270 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 262719000271 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 262719000272 HSP70 interaction site [polypeptide binding]; other site 262719000273 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 262719000274 Zn binding sites [ion binding]; other site 262719000275 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 262719000276 dimer interface [polypeptide binding]; other site 262719000277 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283 262719000278 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 262719000279 CMP-binding site; other site 262719000280 The sites determining sugar specificity; other site 262719000281 GTP-binding protein Der; Reviewed; Region: PRK00093 262719000282 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 262719000283 G1 box; other site 262719000284 GTP/Mg2+ binding site [chemical binding]; other site 262719000285 Switch I region; other site 262719000286 G2 box; other site 262719000287 Switch II region; other site 262719000288 G3 box; other site 262719000289 G4 box; other site 262719000290 G5 box; other site 262719000291 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 262719000292 G1 box; other site 262719000293 GTP/Mg2+ binding site [chemical binding]; other site 262719000294 Switch I region; other site 262719000295 G2 box; other site 262719000296 G3 box; other site 262719000297 Switch II region; other site 262719000298 G4 box; other site 262719000299 G5 box; other site 262719000300 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 262719000301 IHF - DNA interface [nucleotide binding]; other site 262719000302 IHF dimer interface [polypeptide binding]; other site 262719000303 GTP-binding protein LepA; Provisional; Region: PRK05433 262719000304 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 262719000305 G1 box; other site 262719000306 putative GEF interaction site [polypeptide binding]; other site 262719000307 GTP/Mg2+ binding site [chemical binding]; other site 262719000308 Switch I region; other site 262719000309 G2 box; other site 262719000310 G3 box; other site 262719000311 Switch II region; other site 262719000312 G4 box; other site 262719000313 G5 box; other site 262719000314 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 262719000315 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 262719000316 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 262719000317 elongation factor G; Reviewed; Region: PRK12739 262719000318 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 262719000319 G1 box; other site 262719000320 putative GEF interaction site [polypeptide binding]; other site 262719000321 GTP/Mg2+ binding site [chemical binding]; other site 262719000322 Switch I region; other site 262719000323 G2 box; other site 262719000324 G3 box; other site 262719000325 Switch II region; other site 262719000326 G4 box; other site 262719000327 G5 box; other site 262719000328 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 262719000329 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 262719000330 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 262719000331 30S ribosomal protein S7; Validated; Region: PRK05302 262719000332 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 262719000333 S17 interaction site [polypeptide binding]; other site 262719000334 S8 interaction site; other site 262719000335 16S rRNA interaction site [nucleotide binding]; other site 262719000336 streptomycin interaction site [chemical binding]; other site 262719000337 23S rRNA interaction site [nucleotide binding]; other site 262719000338 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 262719000339 Amino acid permease; Region: AA_permease_2; pfam13520 262719000340 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 262719000341 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 262719000342 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 262719000343 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 262719000344 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 262719000345 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 262719000346 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 262719000347 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 262719000348 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 262719000349 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12903 262719000350 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 262719000351 helicase superfamily c-terminal domain; Region: HELICc; smart00490 262719000352 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 262719000353 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 262719000354 GTP/Mg2+ binding site [chemical binding]; other site 262719000355 G4 box; other site 262719000356 G5 box; other site 262719000357 50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926 262719000358 G1 box; other site 262719000359 G1 box; other site 262719000360 GTP/Mg2+ binding site [chemical binding]; other site 262719000361 Switch I region; other site 262719000362 G2 box; other site 262719000363 G2 box; other site 262719000364 G3 box; other site 262719000365 G3 box; other site 262719000366 Switch II region; other site 262719000367 Switch II region; other site 262719000368 Peptidase S8 family domain, uncharacterized subfamily 2; Region: Peptidases_S8_2; cd07488 262719000369 putative catalytic residues [active] 262719000370 putative active site [active] 262719000371 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 262719000372 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 262719000373 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 262719000374 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 262719000375 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 262719000376 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 262719000377 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 262719000378 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 262719000379 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 262719000380 dUTPase; Region: dUTPase_2; pfam08761 262719000381 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 262719000382 active site 262719000383 homodimer interface [polypeptide binding]; other site 262719000384 metal binding site [ion binding]; metal-binding site 262719000385 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 262719000386 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 262719000387 dimer interface [polypeptide binding]; other site 262719000388 catalytic triad [active] 262719000389 peroxidatic and resolving cysteines [active] 262719000390 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 262719000391 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 262719000392 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 262719000393 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 262719000394 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 262719000395 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 262719000396 Walker A motif; other site 262719000397 ATP binding site [chemical binding]; other site 262719000398 Walker B motif; other site 262719000399 arginine finger; other site 262719000400 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 262719000401 Walker A motif; other site 262719000402 ATP binding site [chemical binding]; other site 262719000403 Walker B motif; other site 262719000404 arginine finger; other site 262719000405 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 262719000406 triosephosphate isomerase; Provisional; Region: PRK14565 262719000407 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 262719000408 substrate binding site [chemical binding]; other site 262719000409 dimer interface [polypeptide binding]; other site 262719000410 catalytic triad [active] 262719000411 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 262719000412 16S/18S rRNA binding site [nucleotide binding]; other site 262719000413 S13e-L30e interaction site [polypeptide binding]; other site 262719000414 25S rRNA binding site [nucleotide binding]; other site 262719000415 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 262719000416 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 262719000417 ATP binding site [chemical binding]; other site 262719000418 Mg2+ binding site [ion binding]; other site 262719000419 G-X-G motif; other site 262719000420 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 262719000421 anchoring element; other site 262719000422 dimer interface [polypeptide binding]; other site 262719000423 ATP binding site [chemical binding]; other site 262719000424 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 262719000425 active site 262719000426 putative metal-binding site [ion binding]; other site 262719000427 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 262719000428 6-phosphofructokinase; Provisional; Region: PRK03202 262719000429 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 262719000430 active site 262719000431 ADP/pyrophosphate binding site [chemical binding]; other site 262719000432 dimerization interface [polypeptide binding]; other site 262719000433 allosteric effector site; other site 262719000434 fructose-1,6-bisphosphate binding site; other site 262719000435 Amino acid permease; Region: AA_permease_2; pfam13520 262719000436 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 262719000437 active site 262719000438 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 262719000439 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 262719000440 tetramer interface [polypeptide binding]; other site 262719000441 TPP-binding site [chemical binding]; other site 262719000442 heterodimer interface [polypeptide binding]; other site 262719000443 phosphorylation loop region [posttranslational modification] 262719000444 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 262719000445 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 262719000446 alpha subunit interface [polypeptide binding]; other site 262719000447 TPP binding site [chemical binding]; other site 262719000448 heterodimer interface [polypeptide binding]; other site 262719000449 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 262719000450 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 262719000451 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 262719000452 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 262719000453 23S rRNA binding site [nucleotide binding]; other site 262719000454 L21 binding site [polypeptide binding]; other site 262719000455 L13 binding site [polypeptide binding]; other site 262719000456 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 262719000457 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 262719000458 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 262719000459 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 262719000460 pyruvate kinase; Provisional; Region: PRK05826 262719000461 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 262719000462 domain interfaces; other site 262719000463 active site 262719000464 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 262719000465 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 262719000466 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 262719000467 oligomer interface [polypeptide binding]; other site 262719000468 active site 262719000469 metal binding site [ion binding]; metal-binding site 262719000470 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 262719000471 ligand binding site [chemical binding]; other site 262719000472 active site 262719000473 UGI interface [polypeptide binding]; other site 262719000474 catalytic site [active] 262719000475 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 262719000476 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 262719000477 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 262719000478 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 262719000479 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 262719000480 nucleophilic elbow; other site 262719000481 catalytic triad; other site 262719000482 Uncharacterized conserved protein [Function unknown]; Region: COG1284 262719000483 Major Facilitator Superfamily; Region: MFS_1; pfam07690 262719000484 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 262719000485 putative substrate translocation pore; other site 262719000486 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 262719000487 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 262719000488 NAD binding site [chemical binding]; other site 262719000489 dimer interface [polypeptide binding]; other site 262719000490 tetramer (dimer of dimers) interface [polypeptide binding]; other site 262719000491 substrate binding site [chemical binding]; other site 262719000492 Putative peptidase (DUF31); Region: DUF31; pfam01732 262719000493 peptide chain release factor 1; Validated; Region: prfA; PRK00591 262719000494 This domain is found in peptide chain release factors; Region: PCRF; smart00937 262719000495 RF-1 domain; Region: RF-1; pfam00472 262719000496 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 262719000497 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262719000498 S-adenosylmethionine binding site [chemical binding]; other site 262719000499 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 262719000500 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 262719000501 active site 262719000502 HIGH motif; other site 262719000503 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 262719000504 active site 262719000505 KMSKS motif; other site 262719000506 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 262719000507 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 262719000508 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 262719000509 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 262719000510 Chromate transporter; Region: Chromate_transp; pfam02417 262719000511 Chromate transporter; Region: Chromate_transp; cl17781 262719000512 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 262719000513 Hsp33 protein; Region: HSP33; pfam01430 262719000514 dimerization interface [polypeptide binding]; other site 262719000515 domain crossover interface; other site 262719000516 redox-dependent activation switch; other site 262719000517 Competence-damaged protein; Region: CinA; pfam02464 262719000518 trigger factor; Provisional; Region: tig; PRK01490 262719000519 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 262719000520 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 262719000521 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 262719000522 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 262719000523 substrate binding site [chemical binding]; other site 262719000524 hexamer interface [polypeptide binding]; other site 262719000525 metal binding site [ion binding]; metal-binding site 262719000526 GTPase RsgA; Reviewed; Region: PRK00098 262719000527 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 262719000528 RNA binding site [nucleotide binding]; other site 262719000529 homodimer interface [polypeptide binding]; other site 262719000530 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 262719000531 GTPase/Zn-binding domain interface [polypeptide binding]; other site 262719000532 GTP/Mg2+ binding site [chemical binding]; other site 262719000533 G4 box; other site 262719000534 G5 box; other site 262719000535 G1 box; other site 262719000536 Switch I region; other site 262719000537 G2 box; other site 262719000538 G3 box; other site 262719000539 Switch II region; other site 262719000540 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 262719000541 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 262719000542 catalytic site [active] 262719000543 G-X2-G-X-G-K; other site 262719000544 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 262719000545 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262719000546 S-adenosylmethionine binding site [chemical binding]; other site 262719000547 Recombination protein O N terminal; Region: RecO_N; pfam11967 262719000548 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 262719000549 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 262719000550 GTPase Era; Reviewed; Region: era; PRK00089 262719000551 G1 box; other site 262719000552 GTP/Mg2+ binding site [chemical binding]; other site 262719000553 Switch I region; other site 262719000554 G2 box; other site 262719000555 Switch II region; other site 262719000556 G3 box; other site 262719000557 G4 box; other site 262719000558 KH domain; Region: KH_2; pfam07650 262719000559 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 262719000560 active site 262719000561 catalytic motif [active] 262719000562 Zn binding site [ion binding]; other site 262719000563 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 262719000564 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 262719000565 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39E; cd02424 262719000566 putative active site [active] 262719000567 Keratinocyte-associated protein 2; Region: Keratin_assoc; pfam09775 262719000568 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 262719000569 Walker A/P-loop; other site 262719000570 ATP binding site [chemical binding]; other site 262719000571 Q-loop/lid; other site 262719000572 ABC transporter signature motif; other site 262719000573 Walker B; other site 262719000574 D-loop; other site 262719000575 H-loop/switch region; other site 262719000576 phosphopentomutase; Provisional; Region: PRK05362 262719000577 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 262719000578 transcription antitermination factor NusB; Region: nusB; TIGR01951 262719000579 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 262719000580 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 262719000581 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 262719000582 Aminotransferase class-V; Region: Aminotran_5; pfam00266 262719000583 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 262719000584 catalytic residue [active] 262719000585 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 262719000586 trimerization site [polypeptide binding]; other site 262719000587 active site 262719000588 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 262719000589 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 262719000590 RNA binding surface [nucleotide binding]; other site 262719000591 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 262719000592 active site 262719000593 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 262719000594 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 262719000595 alphaNTD homodimer interface [polypeptide binding]; other site 262719000596 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 262719000597 alphaNTD - beta interaction site [polypeptide binding]; other site 262719000598 alphaNTD - beta' interaction site [polypeptide binding]; other site 262719000599 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 262719000600 30S ribosomal protein S11; Validated; Region: PRK05309 262719000601 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 262719000602 30S ribosomal protein S13; Region: bact_S13; TIGR03631 262719000603 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 262719000604 rRNA binding site [nucleotide binding]; other site 262719000605 predicted 30S ribosome binding site; other site 262719000606 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 262719000607 active site 262719000608 adenylate kinase; Region: adk; TIGR01351 262719000609 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 262719000610 AMP-binding site [chemical binding]; other site 262719000611 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 262719000612 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 262719000613 SecY translocase; Region: SecY; pfam00344 262719000614 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 262719000615 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 262719000616 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 262719000617 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 262719000618 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 262719000619 5S rRNA interface [nucleotide binding]; other site 262719000620 23S rRNA interface [nucleotide binding]; other site 262719000621 L5 interface [polypeptide binding]; other site 262719000622 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 262719000623 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 262719000624 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 262719000625 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 262719000626 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 262719000627 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 262719000628 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 262719000629 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 262719000630 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 262719000631 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 262719000632 RNA binding site [nucleotide binding]; other site 262719000633 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 262719000634 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 262719000635 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 262719000636 23S rRNA interface [nucleotide binding]; other site 262719000637 putative translocon interaction site; other site 262719000638 signal recognition particle (SRP54) interaction site; other site 262719000639 L23 interface [polypeptide binding]; other site 262719000640 trigger factor interaction site; other site 262719000641 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 262719000642 23S rRNA interface [nucleotide binding]; other site 262719000643 5S rRNA interface [nucleotide binding]; other site 262719000644 putative antibiotic binding site [chemical binding]; other site 262719000645 L25 interface [polypeptide binding]; other site 262719000646 L27 interface [polypeptide binding]; other site 262719000647 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 262719000648 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 262719000649 G-X-X-G motif; other site 262719000650 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 262719000651 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 262719000652 putative translocon binding site; other site 262719000653 protein-rRNA interface [nucleotide binding]; other site 262719000654 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 262719000655 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 262719000656 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 262719000657 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 262719000658 50S ribosomal protein L23; Reviewed; Region: rplW; PRK12280 262719000659 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 262719000660 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 262719000661 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 262719000662 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 262719000663 RNA methyltransferase, RsmE family; Region: TIGR00046 262719000664 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 262719000665 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 262719000666 motif 1; other site 262719000667 active site 262719000668 motif 2; other site 262719000669 motif 3; other site 262719000670 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 262719000671 DHHA1 domain; Region: DHHA1; pfam02272 262719000672 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 262719000673 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 262719000674 putative active site [active] 262719000675 catalytic residue [active] 262719000676 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 262719000677 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 262719000678 Ligand Binding Site [chemical binding]; other site 262719000679 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 262719000680 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 262719000681 Walker B motif; other site 262719000682 arginine finger; other site 262719000683 Peptidase family M41; Region: Peptidase_M41; pfam01434 262719000684 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 262719000685 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 262719000686 dimer interface [polypeptide binding]; other site 262719000687 putative anticodon binding site; other site 262719000688 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 262719000689 motif 1; other site 262719000690 active site 262719000691 motif 2; other site 262719000692 motif 3; other site 262719000693 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 262719000694 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 262719000695 active site 262719000696 motif I; other site 262719000697 motif II; other site 262719000698 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 262719000699 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 262719000700 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 262719000701 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 262719000702 trmE is a tRNA modification GTPase; Region: trmE; cd04164 262719000703 G1 box; other site 262719000704 GTP/Mg2+ binding site [chemical binding]; other site 262719000705 Switch I region; other site 262719000706 G2 box; other site 262719000707 Switch II region; other site 262719000708 G3 box; other site 262719000709 G4 box; other site 262719000710 G5 box; other site 262719000711 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 262719000712 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262719000713 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 262719000714 Walker A/P-loop; other site 262719000715 ATP binding site [chemical binding]; other site 262719000716 Q-loop/lid; other site 262719000717 ABC transporter signature motif; other site 262719000718 Walker B; other site 262719000719 D-loop; other site 262719000720 H-loop/switch region; other site 262719000721 ABC transporter; Region: ABC_tran_2; pfam12848 262719000722 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 262719000723 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 262719000724 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262719000725 dimer interface [polypeptide binding]; other site 262719000726 conserved gate region; other site 262719000727 putative PBP binding loops; other site 262719000728 ABC-ATPase subunit interface; other site 262719000729 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 262719000730 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 262719000731 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 262719000732 Walker A/P-loop; other site 262719000733 ATP binding site [chemical binding]; other site 262719000734 Q-loop/lid; other site 262719000735 ABC transporter signature motif; other site 262719000736 Walker B; other site 262719000737 D-loop; other site 262719000738 H-loop/switch region; other site 262719000739 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 262719000740 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262719000741 Walker A/P-loop; other site 262719000742 ATP binding site [chemical binding]; other site 262719000743 Q-loop/lid; other site 262719000744 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 262719000745 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 262719000746 ABC transporter signature motif; other site 262719000747 Walker B; other site 262719000748 D-loop; other site 262719000749 H-loop/switch region; other site 262719000750 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 262719000751 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 262719000752 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 262719000753 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07187 262719000754 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 262719000755 Class I ribonucleotide reductase; Region: RNR_I; cd01679 262719000756 active site 262719000757 dimer interface [polypeptide binding]; other site 262719000758 catalytic residues [active] 262719000759 effector binding site; other site 262719000760 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 262719000761 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 262719000762 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 262719000763 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 262719000764 dimer interface [polypeptide binding]; other site 262719000765 putative radical transfer pathway; other site 262719000766 diiron center [ion binding]; other site 262719000767 tyrosyl radical; other site 262719000768 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 262719000769 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 262719000770 dimer interface [polypeptide binding]; other site 262719000771 active site 262719000772 glycine-pyridoxal phosphate binding site [chemical binding]; other site 262719000773 folate binding site [chemical binding]; other site 262719000774 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 262719000775 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 262719000776 tetrameric interface [polypeptide binding]; other site 262719000777 NAD binding site [chemical binding]; other site 262719000778 catalytic residues [active] 262719000779 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 262719000780 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 262719000781 substrate binding site [chemical binding]; other site 262719000782 ATP binding site [chemical binding]; other site 262719000783 KduI/IolB family; Region: KduI; cl01508 262719000784 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 262719000785 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 262719000786 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 262719000787 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 262719000788 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 262719000789 PYR/PP interface [polypeptide binding]; other site 262719000790 dimer interface [polypeptide binding]; other site 262719000791 TPP binding site [chemical binding]; other site 262719000792 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 262719000793 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 262719000794 TPP-binding site; other site 262719000795 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 262719000796 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 262719000797 AP (apurinic/apyrimidinic) site pocket; other site 262719000798 Metal-binding active site; metal-binding site 262719000799 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 262719000800 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 262719000801 Walker A/P-loop; other site 262719000802 ATP binding site [chemical binding]; other site 262719000803 Q-loop/lid; other site 262719000804 ABC transporter signature motif; other site 262719000805 Walker B; other site 262719000806 D-loop; other site 262719000807 H-loop/switch region; other site 262719000808 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 262719000809 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 262719000810 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 262719000811 TM-ABC transporter signature motif; other site 262719000812 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 262719000813 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 262719000814 ligand binding site [chemical binding]; other site 262719000815 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 262719000816 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 262719000817 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 262719000818 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 262719000819 Protein export membrane protein; Region: SecD_SecF; cl14618 262719000820 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 262719000821 Protein export membrane protein; Region: SecD_SecF; cl14618 262719000822 histidyl-tRNA synthetase; Region: hisS; TIGR00442 262719000823 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 262719000824 dimer interface [polypeptide binding]; other site 262719000825 motif 1; other site 262719000826 active site 262719000827 motif 2; other site 262719000828 motif 3; other site 262719000829 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 262719000830 anticodon binding site; other site 262719000831 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 262719000832 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 262719000833 dimer interface [polypeptide binding]; other site 262719000834 anticodon binding site; other site 262719000835 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 262719000836 motif 1; other site 262719000837 dimer interface [polypeptide binding]; other site 262719000838 active site 262719000839 motif 2; other site 262719000840 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 262719000841 active site 262719000842 motif 3; other site 262719000843 Domain of unknown function (DUF386); Region: DUF386; cl01047 262719000844 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 262719000845 AAA-like domain; Region: AAA_10; pfam12846 262719000846 Domain of unknown function DUF87; Region: DUF87; pfam01935 262719000847 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 262719000848 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 262719000849 DNA protecting protein DprA; Region: dprA; TIGR00732 262719000850 enolase; Provisional; Region: eno; PRK00077 262719000851 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 262719000852 dimer interface [polypeptide binding]; other site 262719000853 metal binding site [ion binding]; metal-binding site 262719000854 substrate binding pocket [chemical binding]; other site 262719000855 seryl-tRNA synthetase; Provisional; Region: PRK05431 262719000856 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 262719000857 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 262719000858 dimer interface [polypeptide binding]; other site 262719000859 active site 262719000860 motif 1; other site 262719000861 motif 2; other site 262719000862 motif 3; other site 262719000863 DJ-1 family protein; Region: not_thiJ; TIGR01383 262719000864 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 262719000865 conserved cys residue [active] 262719000866 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 262719000867 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 262719000868 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 262719000869 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 262719000870 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07133 262719000871 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 262719000872 Walker A motif; other site 262719000873 ATP binding site [chemical binding]; other site 262719000874 Walker B motif; other site 262719000875 arginine finger; other site 262719000876 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0718 262719000877 recombination protein RecR; Reviewed; Region: recR; PRK00076 262719000878 RecR protein; Region: RecR; pfam02132 262719000879 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 262719000880 putative active site [active] 262719000881 putative metal-binding site [ion binding]; other site 262719000882 tetramer interface [polypeptide binding]; other site 262719000883 thymidylate kinase; Validated; Region: tmk; PRK00698 262719000884 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 262719000885 TMP-binding site; other site 262719000886 ATP-binding site [chemical binding]; other site 262719000887 DNA polymerase III subunit delta'; Validated; Region: PRK07132 262719000888 DNA polymerase III subunit delta'; Validated; Region: PRK08485 262719000889 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 262719000890 putative SAM binding site [chemical binding]; other site 262719000891 putative homodimer interface [polypeptide binding]; other site 262719000892 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 262719000893 active site 262719000894 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13632 262719000895 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 262719000896 Walker A/P-loop; other site 262719000897 ATP binding site [chemical binding]; other site 262719000898 Q-loop/lid; other site 262719000899 ABC transporter signature motif; other site 262719000900 Walker B; other site 262719000901 D-loop; other site 262719000902 H-loop/switch region; other site 262719000903 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13651 262719000904 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 262719000905 Walker A/P-loop; other site 262719000906 ATP binding site [chemical binding]; other site 262719000907 Q-loop/lid; other site 262719000908 ABC transporter signature motif; other site 262719000909 Walker B; other site 262719000910 D-loop; other site 262719000911 H-loop/switch region; other site 262719000912 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 262719000913 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 262719000914 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 262719000915 nucleotide binding pocket [chemical binding]; other site 262719000916 K-X-D-G motif; other site 262719000917 catalytic site [active] 262719000918 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 262719000919 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 262719000920 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038 262719000921 hypothetical protein; Provisional; Region: PRK13671 262719000922 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 262719000923 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 262719000924 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 262719000925 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 262719000926 Soluble P-type ATPase [General function prediction only]; Region: COG4087 262719000927 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 262719000928 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 262719000929 SmpB-tmRNA interface; other site 262719000930 Staphylococcal nuclease homologues; Region: SNc; smart00318 262719000931 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 262719000932 Catalytic site; other site 262719000933 DNA polymerase III PolC; Validated; Region: polC; PRK00448 262719000934 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 262719000935 dimer interface [polypeptide binding]; other site 262719000936 motif 1; other site 262719000937 active site 262719000938 motif 2; other site 262719000939 motif 3; other site 262719000940 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 262719000941 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 262719000942 putative tRNA-binding site [nucleotide binding]; other site 262719000943 tRNA synthetase B5 domain; Region: B5; pfam03484 262719000944 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 262719000945 motif 1; other site 262719000946 dimer interface [polypeptide binding]; other site 262719000947 active site 262719000948 motif 3; other site 262719000949 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 262719000950 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02193 262719000951 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 262719000952 RNA binding site [nucleotide binding]; other site 262719000953 active site 262719000954 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 262719000955 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 262719000956 active site 262719000957 motif I; other site 262719000958 motif II; other site 262719000959 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 262719000960 hypothetical protein; Provisional; Region: PRK07143 262719000961 Cytidylyltransferase-like domain; Region: cytidylyltransferase_like; cd02039 262719000962 active site 262719000963 (T/H)XGH motif; other site 262719000964 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 262719000965 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 262719000966 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 262719000967 putative active site [active] 262719000968 CTP synthetase; Validated; Region: pyrG; PRK05380 262719000969 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 262719000970 Catalytic site [active] 262719000971 active site 262719000972 UTP binding site [chemical binding]; other site 262719000973 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 262719000974 active site 262719000975 putative oxyanion hole; other site 262719000976 catalytic triad [active] 262719000977 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 262719000978 DNA topoisomerase I; Validated; Region: PRK05582 262719000979 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 262719000980 active site 262719000981 metal binding site [ion binding]; metal-binding site 262719000982 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 262719000983 domain I; other site 262719000984 DNA binding groove [nucleotide binding] 262719000985 phosphate binding site [ion binding]; other site 262719000986 domain II; other site 262719000987 domain III; other site 262719000988 nucleotide binding site [chemical binding]; other site 262719000989 catalytic site [active] 262719000990 domain IV; other site 262719000991 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 262719000992 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 262719000993 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 262719000994 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 262719000995 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 262719000996 ABC transporter signature motif; other site 262719000997 Walker B; other site 262719000998 D-loop; other site 262719000999 H-loop/switch region; other site 262719001000 FtsX-like permease family; Region: FtsX; pfam02687 262719001001 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 262719001002 GTP-binding protein YchF; Reviewed; Region: PRK09601 262719001003 YchF GTPase; Region: YchF; cd01900 262719001004 G1 box; other site 262719001005 GTP/Mg2+ binding site [chemical binding]; other site 262719001006 Switch I region; other site 262719001007 G2 box; other site 262719001008 Switch II region; other site 262719001009 G3 box; other site 262719001010 G4 box; other site 262719001011 G5 box; other site 262719001012 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 262719001013 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 262719001014 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 262719001015 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 262719001016 dimer interface [polypeptide binding]; other site 262719001017 ssDNA binding site [nucleotide binding]; other site 262719001018 tetramer (dimer of dimers) interface [polypeptide binding]; other site 262719001019 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 262719001020 Peptidase S7, Flavivirus NS3 serine protease; Region: Peptidase_S7; pfam00949 262719001021 Major Facilitator Superfamily; Region: MFS_1; pfam07690 262719001022 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 262719001023 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 262719001024 active site 262719001025 catalytic site [active] 262719001026 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 262719001027 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262719001028 Walker A/P-loop; other site 262719001029 ATP binding site [chemical binding]; other site 262719001030 Q-loop/lid; other site 262719001031 ABC transporter signature motif; other site 262719001032 Walker B; other site 262719001033 D-loop; other site 262719001034 H-loop/switch region; other site 262719001035 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 262719001036 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262719001037 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 262719001038 Walker A/P-loop; other site 262719001039 ATP binding site [chemical binding]; other site 262719001040 Q-loop/lid; other site 262719001041 ABC transporter signature motif; other site 262719001042 Walker B; other site 262719001043 D-loop; other site 262719001044 H-loop/switch region; other site 262719001045 FtsX-like permease family; Region: FtsX; pfam02687 262719001046 GA module; Region: GA; cl08325 262719001047 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 262719001048 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 262719001049 putative active site [active] 262719001050 putative FMN binding site [chemical binding]; other site 262719001051 putative substrate binding site [chemical binding]; other site 262719001052 putative catalytic residue [active] 262719001053 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 262719001054 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 262719001055 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 262719001056 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 262719001057 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 262719001058 lipoyl attachment site [posttranslational modification]; other site 262719001059 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 262719001060 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262719001061 Walker A/P-loop; other site 262719001062 ATP binding site [chemical binding]; other site 262719001063 Q-loop/lid; other site 262719001064 ABC transporter signature motif; other site 262719001065 Walker B; other site 262719001066 D-loop; other site 262719001067 H-loop/switch region; other site 262719001068 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 262719001069 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 262719001070 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262719001071 Walker A/P-loop; other site 262719001072 ATP binding site [chemical binding]; other site 262719001073 Q-loop/lid; other site 262719001074 ABC transporter signature motif; other site 262719001075 Walker B; other site 262719001076 D-loop; other site 262719001077 H-loop/switch region; other site 262719001078 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 262719001079 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 262719001080 ATP binding site [chemical binding]; other site 262719001081 putative Mg++ binding site [ion binding]; other site 262719001082 Transposase [DNA replication, recombination, and repair]; Region: COG5421 262719001083 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 262719001084 Methyltransferase domain; Region: Methyltransf_26; pfam13659 262719001085 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 262719001086 LemA family; Region: LemA; cl00742 262719001087 Transposase [DNA replication, recombination, and repair]; Region: COG5421 262719001088 Peptidase S8 family domain, uncharacterized subfamily 2; Region: Peptidases_S8_2; cd07488 262719001089 putative catalytic residues [active] 262719001090 putative active site [active] 262719001091 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 262719001092 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 262719001093 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262719001094 Walker A/P-loop; other site 262719001095 ATP binding site [chemical binding]; other site 262719001096 Q-loop/lid; other site 262719001097 ABC transporter signature motif; other site 262719001098 Walker B; other site 262719001099 D-loop; other site 262719001100 H-loop/switch region; other site 262719001101 Transposase, Mutator family; Region: Transposase_mut; pfam00872 262719001102 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 262719001103 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 262719001104 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 262719001105 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 262719001106 dephospho-CoA kinase; Region: TIGR00152 262719001107 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 262719001108 active site 262719001109 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 262719001110 nucleotide binding site/active site [active] 262719001111 glutamylglutaminyl-tRNA synthetase; Provisional; Region: PRK12410 262719001112 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 262719001113 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 262719001114 amphipathic channel; other site 262719001115 Asn-Pro-Ala signature motifs; other site 262719001116 glycerol kinase; Provisional; Region: glpK; PRK00047 262719001117 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 262719001118 N- and C-terminal domain interface [polypeptide binding]; other site 262719001119 active site 262719001120 MgATP binding site [chemical binding]; other site 262719001121 catalytic site [active] 262719001122 metal binding site [ion binding]; metal-binding site 262719001123 glycerol binding site [chemical binding]; other site 262719001124 homotetramer interface [polypeptide binding]; other site 262719001125 homodimer interface [polypeptide binding]; other site 262719001126 FBP binding site [chemical binding]; other site 262719001127 protein IIAGlc interface [polypeptide binding]; other site 262719001128 High affinity transport system protein p37; Region: Mycoplasma_p37; pfam06646 262719001129 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 262719001130 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262719001131 Walker A/P-loop; other site 262719001132 ATP binding site [chemical binding]; other site 262719001133 Q-loop/lid; other site 262719001134 ABC transporter signature motif; other site 262719001135 Walker B; other site 262719001136 D-loop; other site 262719001137 H-loop/switch region; other site 262719001138 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 262719001139 Competence protein; Region: Competence; cl00471 262719001140 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 262719001141 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 262719001142 Mycoplasma MG185/MG260 protein; Region: Lipoprotein_X; pfam03305 262719001143 Putative mycoplasma lipoprotein, C-terminal region; Region: Lipoprotein_10; pfam03202 262719001144 Mycoplasma MG185/MG260 protein; Region: Lipoprotein_X; pfam03305 262719001145 Putative mycoplasma lipoprotein, C-terminal region; Region: Lipoprotein_10; pfam03202 262719001146 Staphylococcal nuclease homologues; Region: SNc; smart00318 262719001147 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 262719001148 Catalytic site; other site 262719001149 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 262719001150 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262719001151 Walker A/P-loop; other site 262719001152 ATP binding site [chemical binding]; other site 262719001153 Q-loop/lid; other site 262719001154 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262719001155 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 262719001156 ABC transporter signature motif; other site 262719001157 Walker B; other site 262719001158 D-loop; other site 262719001159 H-loop/switch region; other site 262719001160 TOBE domain; Region: TOBE_2; pfam08402 262719001161 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262719001162 dimer interface [polypeptide binding]; other site 262719001163 conserved gate region; other site 262719001164 putative PBP binding loops; other site 262719001165 ABC-ATPase subunit interface; other site 262719001166 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 262719001167 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262719001168 dimer interface [polypeptide binding]; other site 262719001169 conserved gate region; other site 262719001170 putative PBP binding loops; other site 262719001171 ABC-ATPase subunit interface; other site 262719001172 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 262719001173 active site 262719001174 phosphorylation site [posttranslational modification] 262719001175 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 262719001176 active site 262719001177 P-loop; other site 262719001178 phosphorylation site [posttranslational modification] 262719001179 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 262719001180 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 262719001181 active site 262719001182 substrate binding pocket [chemical binding]; other site 262719001183 homodimer interaction site [polypeptide binding]; other site 262719001184 Putative mycoplasma lipoprotein, C-terminal region; Region: Lipoprotein_10; pfam03202 262719001185 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14267 262719001186 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262719001187 Walker A/P-loop; other site 262719001188 ATP binding site [chemical binding]; other site 262719001189 Q-loop/lid; other site 262719001190 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262719001191 ABC transporter signature motif; other site 262719001192 Walker B; other site 262719001193 D-loop; other site 262719001194 H-loop/switch region; other site 262719001195 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 262719001196 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 262719001197 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 262719001198 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 262719001199 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262719001200 Walker A/P-loop; other site 262719001201 ATP binding site [chemical binding]; other site 262719001202 Q-loop/lid; other site 262719001203 ABC transporter signature motif; other site 262719001204 Walker B; other site 262719001205 D-loop; other site 262719001206 H-loop/switch region; other site 262719001207 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 262719001208 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 262719001209 catalytic residues [active] 262719001210 prolyl-tRNA synthetase; Provisional; Region: PRK08661 262719001211 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 262719001212 dimer interface [polypeptide binding]; other site 262719001213 motif 1; other site 262719001214 active site 262719001215 motif 2; other site 262719001216 motif 3; other site 262719001217 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 262719001218 anticodon binding site; other site 262719001219 DNA methylase; Region: N6_N4_Mtase; pfam01555 262719001220 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 262719001221 DNA methylase; Region: N6_N4_Mtase; cl17433 262719001222 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 262719001223 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 262719001224 ATP binding site [chemical binding]; other site 262719001225 putative Mg++ binding site [ion binding]; other site 262719001226 Integrase core domain; Region: rve; pfam00665 262719001227 Integrase core domain; Region: rve_3; cl15866 262719001228 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 262719001229 Integrase core domain; Region: rve; pfam00665 262719001230 Integrase core domain; Region: rve_3; cl15866 262719001231 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 262719001232 active site 262719001233 catalytic residues [active] 262719001234 SUR7/PalI family; Region: SUR7; pfam06687 262719001235 cell division protein MraZ; Reviewed; Region: PRK00326 262719001236 MraZ protein; Region: MraZ; pfam02381 262719001237 MraZ protein; Region: MraZ; pfam02381 262719001238 MraW methylase family; Region: Methyltransf_5; cl17771 262719001239 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 262719001240 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 262719001241 nucleotide binding site [chemical binding]; other site 262719001242 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 262719001243 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 262719001244 active site 262719001245 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 262719001246 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262719001247 S-adenosylmethionine binding site [chemical binding]; other site 262719001248 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 262719001249 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 262719001250 active site 262719001251 HIGH motif; other site 262719001252 KMSKS motif; other site 262719001253 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 262719001254 tRNA binding surface [nucleotide binding]; other site 262719001255 anticodon binding site; other site 262719001256 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 262719001257 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 262719001258 dimerization interface [polypeptide binding]; other site 262719001259 active site 262719001260 metal binding site [ion binding]; metal-binding site 262719001261 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 262719001262 dsRNA binding site [nucleotide binding]; other site 262719001263 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 262719001264 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 262719001265 putative dimer interface [polypeptide binding]; other site 262719001266 putative anticodon binding site; other site 262719001267 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 262719001268 motif 1; other site 262719001269 dimer interface [polypeptide binding]; other site 262719001270 active site 262719001271 motif 2; other site 262719001272 motif 3; other site 262719001273 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 262719001274 Part of AAA domain; Region: AAA_19; pfam13245 262719001275 Family description; Region: UvrD_C_2; pfam13538 262719001276 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 262719001277 RuvA N terminal domain; Region: RuvA_N; pfam01330 262719001278 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 262719001279 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 262719001280 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 262719001281 Walker A motif; other site 262719001282 ATP binding site [chemical binding]; other site 262719001283 Walker B motif; other site 262719001284 arginine finger; other site 262719001285 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 262719001286 Domain of unknown function(DUF2779); Region: DUF2779; pfam11074 262719001287 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 262719001288 DNA methylase; Region: N6_N4_Mtase; pfam01555 262719001289 DNA methylase; Region: N6_N4_Mtase; cl17433 262719001290 elongation factor P; Validated; Region: PRK00529 262719001291 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 262719001292 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 262719001293 RNA binding site [nucleotide binding]; other site 262719001294 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 262719001295 RNA binding site [nucleotide binding]; other site 262719001296 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 262719001297 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 262719001298 TPP-binding site [chemical binding]; other site 262719001299 dimer interface [polypeptide binding]; other site 262719001300 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 262719001301 PYR/PP interface [polypeptide binding]; other site 262719001302 dimer interface [polypeptide binding]; other site 262719001303 TPP binding site [chemical binding]; other site 262719001304 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 262719001305 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 262719001306 Ligand Binding Site [chemical binding]; other site 262719001307 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 262719001308 substrate binding site [chemical binding]; other site 262719001309 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 262719001310 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 262719001311 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 262719001312 active site 262719001313 motif I; other site 262719001314 motif II; other site 262719001315 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 262719001316 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 262719001317 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 262719001318 intersubunit interface [polypeptide binding]; other site 262719001319 active site 262719001320 Zn2+ binding site [ion binding]; other site 262719001321 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 262719001322 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 262719001323 AP (apurinic/apyrimidinic) site pocket; other site 262719001324 DNA interaction; other site 262719001325 Metal-binding active site; metal-binding site 262719001326 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 262719001327 active site 262719001328 dimer interface [polypeptide binding]; other site 262719001329 magnesium binding site [ion binding]; other site 262719001330 Transposase [DNA replication, recombination, and repair]; Region: COG5421 262719001331 Hypothetical protein; Provisional; Region: PHA02951 262719001332 Protein of unknown function (DUF1410); Region: DUF1410; pfam07198 262719001333 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 262719001334 G1 box; other site 262719001335 GTP/Mg2+ binding site [chemical binding]; other site 262719001336 Switch I region; other site 262719001337 G2 box; other site 262719001338 G3 box; other site 262719001339 Switch II region; other site 262719001340 G4 box; other site 262719001341 G5 box; other site 262719001342 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 262719001343 active site 262719001344 metal binding site [ion binding]; metal-binding site 262719001345 S-adenosylmethionine synthetase; Validated; Region: PRK05250 262719001346 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 262719001347 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 262719001348 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 262719001349 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 262719001350 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 262719001351 Walker A/P-loop; other site 262719001352 ATP binding site [chemical binding]; other site 262719001353 Q-loop/lid; other site 262719001354 ABC transporter signature motif; other site 262719001355 Walker B; other site 262719001356 D-loop; other site 262719001357 H-loop/switch region; other site 262719001358 FtsX-like permease family; Region: FtsX; pfam02687 262719001359 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 262719001360 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 262719001361 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 262719001362 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 262719001363 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 262719001364 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 262719001365 Ferritin-like domain; Region: Ferritin; pfam00210 262719001366 dimerization interface [polypeptide binding]; other site 262719001367 DPS ferroxidase diiron center [ion binding]; other site 262719001368 ion pore; other site 262719001369 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 262719001370 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 262719001371 active site 262719001372 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 262719001373 mRNA/rRNA interface [nucleotide binding]; other site 262719001374 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 262719001375 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 262719001376 23S rRNA interface [nucleotide binding]; other site 262719001377 L7/L12 interface [polypeptide binding]; other site 262719001378 putative thiostrepton binding site; other site 262719001379 L25 interface [polypeptide binding]; other site 262719001380 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 262719001381 interface (dimer of trimers) [polypeptide binding]; other site 262719001382 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 262719001383 Substrate-binding/catalytic site; other site 262719001384 Zn-binding sites [ion binding]; other site 262719001385 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 262719001386 aromatic cluster surface protein; Region: aro_clust_Mycop; TIGR04313 262719001387 aromatic cluster surface protein; Region: aro_clust_Mycop; TIGR04313 262719001388 aromatic cluster surface protein; Region: aro_clust_Mycop; TIGR04313 262719001389 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 262719001390 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 262719001391 Walker A/P-loop; other site 262719001392 ATP binding site [chemical binding]; other site 262719001393 Q-loop/lid; other site 262719001394 ABC transporter signature motif; other site 262719001395 Walker B; other site 262719001396 D-loop; other site 262719001397 H-loop/switch region; other site 262719001398 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 262719001399 NAD(P) binding site [chemical binding]; other site 262719001400 LDH/MDH dimer interface [polypeptide binding]; other site 262719001401 substrate binding site [chemical binding]; other site 262719001402 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 262719001403 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 262719001404 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 262719001405 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 262719001406 NAD synthetase; Provisional; Region: PRK13980 262719001407 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 262719001408 homodimer interface [polypeptide binding]; other site 262719001409 NAD binding pocket [chemical binding]; other site 262719001410 ATP binding pocket [chemical binding]; other site 262719001411 Mg binding site [ion binding]; other site 262719001412 active-site loop [active] 262719001413 hypothetical protein; Validated; Region: PRK00110 262719001414 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Provisional; Region: PRK07164 262719001415 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 262719001416 putative nicotinate-nucleotide adenylyltransferase; Validated; Region: nadD; PRK07152 262719001417 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 262719001418 active site 262719001419 (T/H)XGH motif; other site 262719001420 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 262719001421 Zn2+ binding site [ion binding]; other site 262719001422 Mg2+ binding site [ion binding]; other site 262719001423 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 262719001424 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 262719001425 active site 262719001426 motif I; other site 262719001427 motif II; other site 262719001428 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 262719001429 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 262719001430 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 262719001431 Walker A motif; other site 262719001432 ATP binding site [chemical binding]; other site 262719001433 Walker B motif; other site 262719001434 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 262719001435 F0F1 ATP synthase subunit alpha; Validated; Region: PRK07165 262719001436 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 262719001437 Walker A motif; other site 262719001438 ATP binding site [chemical binding]; other site 262719001439 Walker B motif; other site 262719001440 Protein of unknown function (DUF2714); Region: DUF2714; pfam10896 262719001441 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 262719001442 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 262719001443 active site 262719001444 motif I; other site 262719001445 motif II; other site 262719001446 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 262719001447 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 262719001448 MgtE intracellular N domain; Region: MgtE_N; pfam03448 262719001449 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 262719001450 Divalent cation transporter; Region: MgtE; cl00786 262719001451 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 262719001452 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 262719001453 Phosphoglycerate kinase; Region: PGK; pfam00162 262719001454 substrate binding site [chemical binding]; other site 262719001455 hinge regions; other site 262719001456 ADP binding site [chemical binding]; other site 262719001457 catalytic site [active] 262719001458 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 262719001459 active site 262719001460 phosphorylation site [posttranslational modification] 262719001461 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 262719001462 active site 262719001463 P-loop; other site 262719001464 phosphorylation site [posttranslational modification] 262719001465 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 262719001466 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 262719001467 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 262719001468 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 262719001469 Transposase [DNA replication, recombination, and repair]; Region: COG5421 262719001470 M42 glutamyl aminopeptidase; Region: Peptidase_M42; cl17262 262719001471 asparagine synthetase A; Reviewed; Region: PRK06462 262719001472 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 262719001473 motif 1; other site 262719001474 dimer interface [polypeptide binding]; other site 262719001475 active site 262719001476 motif 2; other site 262719001477 motif 3; other site 262719001478 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262719001479 Walker A/P-loop; other site 262719001480 ATP binding site [chemical binding]; other site 262719001481 Q-loop/lid; other site 262719001482 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 262719001483 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 262719001484 ABC transporter signature motif; other site 262719001485 Walker B; other site 262719001486 D-loop; other site 262719001487 H-loop/switch region; other site 262719001488 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 262719001489 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 262719001490 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 262719001491 Walker A/P-loop; other site 262719001492 ATP binding site [chemical binding]; other site 262719001493 Q-loop/lid; other site 262719001494 ABC transporter signature motif; other site 262719001495 Walker B; other site 262719001496 D-loop; other site 262719001497 H-loop/switch region; other site 262719001498 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 262719001499 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 262719001500 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262719001501 dimer interface [polypeptide binding]; other site 262719001502 ABC-ATPase subunit interface; other site 262719001503 putative PBP binding loops; other site 262719001504 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 262719001505 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262719001506 dimer interface [polypeptide binding]; other site 262719001507 conserved gate region; other site 262719001508 putative PBP binding loops; other site 262719001509 ABC-ATPase subunit interface; other site 262719001510 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 262719001511 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 262719001512 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 262719001513 E3 interaction surface; other site 262719001514 lipoyl attachment site [posttranslational modification]; other site 262719001515 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 262719001516 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 262719001517 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 262719001518 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 262719001519 acetate kinase; Provisional; Region: PRK07157 262719001520 propionate/acetate kinase; Provisional; Region: PRK12379 262719001521 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 262719001522 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 262719001523 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 262719001524 putative ligand binding site [chemical binding]; other site 262719001525 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 262719001526 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 262719001527 Walker A/P-loop; other site 262719001528 ATP binding site [chemical binding]; other site 262719001529 Q-loop/lid; other site 262719001530 ABC transporter signature motif; other site 262719001531 Walker B; other site 262719001532 D-loop; other site 262719001533 H-loop/switch region; other site 262719001534 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 262719001535 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 262719001536 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 262719001537 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 262719001538 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 262719001539 TM-ABC transporter signature motif; other site 262719001540 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 262719001541 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 262719001542 nucleotide binding site [chemical binding]; other site 262719001543 Transposase [DNA replication, recombination, and repair]; Region: COG5421 262719001544 oligoendopeptidase F; Region: pepF; TIGR00181 262719001545 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 262719001546 active site 262719001547 Zn binding site [ion binding]; other site 262719001548 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 262719001549 active site 262719001550 catalytic triad [active] 262719001551 oxyanion hole [active] 262719001552 elongation factor Tu; Reviewed; Region: PRK12736 262719001553 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 262719001554 G1 box; other site 262719001555 GEF interaction site [polypeptide binding]; other site 262719001556 GTP/Mg2+ binding site [chemical binding]; other site 262719001557 Switch I region; other site 262719001558 G2 box; other site 262719001559 G3 box; other site 262719001560 Switch II region; other site 262719001561 G4 box; other site 262719001562 G5 box; other site 262719001563 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 262719001564 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 262719001565 Antibiotic Binding Site [chemical binding]; other site 262719001566 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 262719001567 Walker A motif; other site 262719001568 ATP binding site [chemical binding]; other site 262719001569 Walker B motif; other site 262719001570 arginine finger; other site 262719001571 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 262719001572 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 262719001573 active site 262719001574 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 262719001575 intersubunit interface [polypeptide binding]; other site 262719001576 active site 262719001577 catalytic residue [active] 262719001578 DNA gyrase subunit A; Validated; Region: PRK05560 262719001579 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 262719001580 CAP-like domain; other site 262719001581 active site 262719001582 primary dimer interface [polypeptide binding]; other site 262719001583 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 262719001584 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 262719001585 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 262719001586 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 262719001587 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 262719001588 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 262719001589 methionine sulfoxide reductase B; Provisional; Region: PRK00222 262719001590 SelR domain; Region: SelR; pfam01641 262719001591 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 262719001592 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 262719001593 active site 262719001594 dimer interface [polypeptide binding]; other site 262719001595 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 262719001596 dimer interface [polypeptide binding]; other site 262719001597 active site 262719001598 DNA polymerase III PolC; Validated; Region: polC; PRK00448 262719001599 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 262719001600 active site 262719001601 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 262719001602 active site 262719001603 catalytic site [active] 262719001604 substrate binding site [chemical binding]; other site 262719001605 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 262719001606 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 262719001607 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 262719001608 ribosome recycling factor; Reviewed; Region: frr; PRK00083 262719001609 Ribosome recycling factor; Region: RRF; pfam01765 262719001610 hinge region; other site 262719001611 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 262719001612 putative nucleotide binding site [chemical binding]; other site 262719001613 uridine monophosphate binding site [chemical binding]; other site 262719001614 homohexameric interface [polypeptide binding]; other site 262719001615 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 262719001616 Transposase [DNA replication, recombination, and repair]; Region: COG5421 262719001617 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 262719001618 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 262719001619 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 262719001620 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 262719001621 dimer interface [polypeptide binding]; other site 262719001622 conserved gate region; other site 262719001623 putative PBP binding loops; other site 262719001624 ABC-ATPase subunit interface; other site 262719001625 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262719001626 AAA domain; Region: AAA_21; pfam13304 262719001627 Walker A/P-loop; other site 262719001628 ATP binding site [chemical binding]; other site 262719001629 Q-loop/lid; other site 262719001630 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 262719001631 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262719001632 ABC transporter signature motif; other site 262719001633 Walker B; other site 262719001634 D-loop; other site 262719001635 H-loop/switch region; other site 262719001636 TOBE domain; Region: TOBE_2; pfam08402 262719001637 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 262719001638 TrkA-N domain; Region: TrkA_N; pfam02254 262719001639 TrkA-C domain; Region: TrkA_C; pfam02080 262719001640 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 262719001641 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 262719001642 Transposase [DNA replication, recombination, and repair]; Region: COG5421 262719001643 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 262719001644 active site 262719001645 phosphorylation site [posttranslational modification] 262719001646 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 262719001647 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 262719001648 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 262719001649 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 262719001650 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 262719001651 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 262719001652 active site 262719001653 P-loop; other site 262719001654 phosphorylation site [posttranslational modification] 262719001655 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 262719001656 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 262719001657 putative active site [active] 262719001658 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 262719001659 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 262719001660 active site 262719001661 P-loop; other site 262719001662 phosphorylation site [posttranslational modification] 262719001663 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 262719001664 active site 262719001665 phosphorylation site [posttranslational modification] 262719001666 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 262719001667 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 262719001668 phosphate binding site [ion binding]; other site 262719001669 Transposase [DNA replication, recombination, and repair]; Region: COG5421 262719001670 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 262719001671 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 262719001672 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 262719001673 DEAD-like helicases superfamily; Region: DEXDc; smart00487 262719001674 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 262719001675 ATP binding site [chemical binding]; other site 262719001676 putative Mg++ binding site [ion binding]; other site 262719001677 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_3; cl16254 262719001678 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 262719001679 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 262719001680 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 262719001681 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 262719001682 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 262719001683 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 262719001684 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 262719001685 active site 262719001686 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 262719001687 intersubunit interface [polypeptide binding]; other site 262719001688 active site 262719001689 zinc binding site [ion binding]; other site 262719001690 Na+ binding site [ion binding]; other site 262719001691 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 262719001692 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 262719001693 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 262719001694 active site turn [active] 262719001695 phosphorylation site [posttranslational modification] 262719001696 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 262719001697 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 262719001698 active site 262719001699 trimer interface [polypeptide binding]; other site 262719001700 allosteric site; other site 262719001701 active site lid [active] 262719001702 hexamer (dimer of trimers) interface [polypeptide binding]; other site 262719001703 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 262719001704 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 262719001705 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 262719001706 RNA binding surface [nucleotide binding]; other site 262719001707 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 262719001708 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 262719001709 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 262719001710 DNA binding site [nucleotide binding] 262719001711 catalytic residue [active] 262719001712 H2TH interface [polypeptide binding]; other site 262719001713 putative catalytic residues [active] 262719001714 turnover-facilitating residue; other site 262719001715 intercalation triad [nucleotide binding]; other site 262719001716 8OG recognition residue [nucleotide binding]; other site 262719001717 putative reading head residues; other site 262719001718 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 262719001719 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 262719001720 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 262719001721 active site 262719001722 substrate binding site [chemical binding]; other site 262719001723 ATP binding site [chemical binding]; other site 262719001724 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 262719001725 putative active site [active] 262719001726 putative catalytic site [active] 262719001727 putative Mg binding site IVb [ion binding]; other site 262719001728 putative phosphate binding site [ion binding]; other site 262719001729 putative DNA binding site [nucleotide binding]; other site 262719001730 putative Mg binding site IVa [ion binding]; other site 262719001731 5'-3' exonuclease; Provisional; Region: PRK14976 262719001732 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 262719001733 active site 262719001734 metal binding site 1 [ion binding]; metal-binding site 262719001735 putative 5' ssDNA interaction site; other site 262719001736 metal binding site 3; metal-binding site 262719001737 metal binding site 2 [ion binding]; metal-binding site 262719001738 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 262719001739 putative DNA binding site [nucleotide binding]; other site 262719001740 putative metal binding site [ion binding]; other site 262719001741 DNA polymerase III DnaE; Validated; Region: dnaE; PRK07135 262719001742 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 262719001743 active site 262719001744 PHP Thumb interface [polypeptide binding]; other site 262719001745 Ribosome-binding factor A; Region: RBFA; cl00542 262719001746 translation initiation factor IF-2; Region: IF-2; TIGR00487 262719001747 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 262719001748 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 262719001749 G1 box; other site 262719001750 putative GEF interaction site [polypeptide binding]; other site 262719001751 GTP/Mg2+ binding site [chemical binding]; other site 262719001752 Switch I region; other site 262719001753 G2 box; other site 262719001754 G3 box; other site 262719001755 Switch II region; other site 262719001756 G4 box; other site 262719001757 G5 box; other site 262719001758 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 262719001759 Translation-initiation factor 2; Region: IF-2; pfam11987 262719001760 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 262719001761 transcription termination factor NusA; Region: NusA; TIGR01953 262719001762 NusA N-terminal domain; Region: NusA_N; pfam08529 262719001763 NusA-like KH domain; Region: KH_5; pfam13184 262719001764 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 262719001765 G-X-X-G motif; other site 262719001766 pullulanase, type I; Region: pulA_typeI; TIGR02104 262719001767 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 262719001768 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 262719001769 Ca binding site [ion binding]; other site 262719001770 active site 262719001771 catalytic site [active] 262719001772 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 262719001773 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 262719001774 hydroxyglutarate oxidase; Provisional; Region: PRK11728 262719001775 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 262719001776 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 262719001777 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 262719001778 active site 262719001779 dimer interface [polypeptide binding]; other site 262719001780 motif 1; other site 262719001781 motif 2; other site 262719001782 motif 3; other site 262719001783 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 262719001784 anticodon binding site; other site 262719001785 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 262719001786 active site 262719001787 HIGH motif; other site 262719001788 dimer interface [polypeptide binding]; other site 262719001789 KMSKS motif; other site 262719001790 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 262719001791 active site turn [active] 262719001792 phosphorylation site [posttranslational modification] 262719001793 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 262719001794 AAA domain; Region: AAA_12; pfam13087 262719001795 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 262719001796 RNA/DNA hybrid binding site [nucleotide binding]; other site 262719001797 active site 262719001798 hypothetical protein; Provisional; Region: PRK00523 262719001799 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 262719001800 phosphoglyceromutase; Provisional; Region: PRK05434 262719001801 Plant protein 1589 of unknown function (A_thal_3526); Region: A_thal_3526; cl09915 262719001802 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 262719001803 inorganic pyrophosphatase; Provisional; Region: PRK02230 262719001804 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 262719001805 dimer interface [polypeptide binding]; other site 262719001806 substrate binding site [chemical binding]; other site 262719001807 metal binding sites [ion binding]; metal-binding site 262719001808 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 262719001809 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 262719001810 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 262719001811 Walker A/P-loop; other site 262719001812 ATP binding site [chemical binding]; other site 262719001813 Q-loop/lid; other site 262719001814 ABC transporter signature motif; other site 262719001815 Walker B; other site 262719001816 D-loop; other site 262719001817 H-loop/switch region; other site 262719001818 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 262719001819 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 262719001820 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 262719001821 TM-ABC transporter signature motif; other site 262719001822 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 262719001823 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 262719001824 TM-ABC transporter signature motif; other site 262719001825 thymidine kinase; Provisional; Region: PRK04296 262719001826 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 262719001827 dimerization domain swap beta strand [polypeptide binding]; other site 262719001828 regulatory protein interface [polypeptide binding]; other site 262719001829 active site 262719001830 regulatory phosphorylation site [posttranslational modification]; other site 262719001831 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 262719001832 HPr interaction site; other site 262719001833 glycerol kinase (GK) interaction site [polypeptide binding]; other site 262719001834 active site 262719001835 phosphorylation site [posttranslational modification] 262719001836 Putative peptidase (DUF31); Region: DUF31; pfam01732 262719001837 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 262719001838 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 262719001839 cofactor binding site; other site 262719001840 DNA binding site [nucleotide binding] 262719001841 substrate interaction site [chemical binding]; other site 262719001842 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 262719001843 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 262719001844 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 262719001845 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 262719001846 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 262719001847 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 262719001848 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 262719001849 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 262719001850 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 262719001851 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 262719001852 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 262719001853 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 262719001854 G-loop; other site 262719001855 DNA binding site [nucleotide binding] 262719001856 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 262719001857 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 262719001858 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 262719001859 RPB1 interaction site [polypeptide binding]; other site 262719001860 RPB10 interaction site [polypeptide binding]; other site 262719001861 RPB11 interaction site [polypeptide binding]; other site 262719001862 RPB3 interaction site [polypeptide binding]; other site 262719001863 RPB12 interaction site [polypeptide binding]; other site 262719001864 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 262719001865 core dimer interface [polypeptide binding]; other site 262719001866 peripheral dimer interface [polypeptide binding]; other site 262719001867 L10 interface [polypeptide binding]; other site 262719001868 L11 interface [polypeptide binding]; other site 262719001869 putative EF-Tu interaction site [polypeptide binding]; other site 262719001870 putative EF-G interaction site [polypeptide binding]; other site 262719001871 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 262719001872 23S rRNA interface [nucleotide binding]; other site 262719001873 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 262719001874 Putative peptidase (DUF31); Region: DUF31; pfam01732 262719001875 Putative peptidase (DUF31); Region: DUF31; pfam01732 262719001876 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 262719001877 DpnII restriction endonuclease; Region: DpnII; pfam04556 262719001878 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 262719001879 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 262719001880 Walker A/P-loop; other site 262719001881 ATP binding site [chemical binding]; other site 262719001882 Q-loop/lid; other site 262719001883 ABC transporter signature motif; other site 262719001884 Walker B; other site 262719001885 D-loop; other site 262719001886 H-loop/switch region; other site 262719001887 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 262719001888 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 262719001889 Walker A/P-loop; other site 262719001890 ATP binding site [chemical binding]; other site 262719001891 Q-loop/lid; other site 262719001892 ABC transporter signature motif; other site 262719001893 Walker B; other site 262719001894 D-loop; other site 262719001895 H-loop/switch region; other site 262719001896 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 262719001897 Methyltransferase domain; Region: Methyltransf_26; pfam13659 262719001898 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 262719001899 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 262719001900 Walker A/P-loop; other site 262719001901 ATP binding site [chemical binding]; other site 262719001902 Q-loop/lid; other site 262719001903 ABC transporter signature motif; other site 262719001904 Walker B; other site 262719001905 H-loop/switch region; other site 262719001906 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 262719001907 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 262719001908 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 262719001909 Walker A/P-loop; other site 262719001910 ATP binding site [chemical binding]; other site 262719001911 Q-loop/lid; other site 262719001912 ABC transporter signature motif; other site 262719001913 Walker B; other site 262719001914 D-loop; other site 262719001915 H-loop/switch region; other site 262719001916 Putative peptidase (DUF31); Region: DUF31; pfam01732 262719001917 NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530 262719001918 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 262719001919 putative active site [active] 262719001920 putative metal binding site [ion binding]; other site 262719001921 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 262719001922 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 262719001923 putative acyl-acceptor binding pocket; other site 262719001924 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 262719001925 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 262719001926 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 262719001927 tRNA threonylcarbamoyl adenosine modification protein YgjD; Region: T6A_YgjD; TIGR03723 262719001928 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 262719001929 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 262719001930 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 262719001931 putative homodimer interface [polypeptide binding]; other site 262719001932 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 262719001933 heterodimer interface [polypeptide binding]; other site 262719001934 homodimer interface [polypeptide binding]; other site 262719001935 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 262719001936 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 262719001937 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 262719001938 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 262719001939 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 262719001940 Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: CysS; COG0215 262719001941 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 262719001942 active site 262719001943 HIGH motif; other site 262719001944 nucleotide binding site [chemical binding]; other site 262719001945 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 262719001946 active site 262719001947 KMSKS motif; other site 262719001948 Protein of unknown function DUF45; Region: DUF45; pfam01863 262719001949 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 262719001950 Domain of unknown function DUF21; Region: DUF21; pfam01595 262719001951 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 262719001952 replicative DNA helicase; Region: DnaB; TIGR00665 262719001953 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 262719001954 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 262719001955 Walker A motif; other site 262719001956 ATP binding site [chemical binding]; other site 262719001957 Walker B motif; other site 262719001958 DNA binding loops [nucleotide binding] 262719001959 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 262719001960 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 262719001961 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 262719001962 DHH family; Region: DHH; pfam01368 262719001963 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 262719001964 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 262719001965 HIGH motif; other site 262719001966 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 262719001967 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 262719001968 active site 262719001969 KMSKS motif; other site 262719001970 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 262719001971 tRNA binding surface [nucleotide binding]; other site 262719001972 anticodon binding site; other site 262719001973 excinuclease ABC subunit B; Provisional; Region: PRK05298 262719001974 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 262719001975 ATP binding site [chemical binding]; other site 262719001976 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 262719001977 nucleotide binding region [chemical binding]; other site 262719001978 ATP-binding site [chemical binding]; other site 262719001979 Ultra-violet resistance protein B; Region: UvrB; pfam12344 262719001980 UvrB/uvrC motif; Region: UVR; pfam02151 262719001981 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 262719001982 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 262719001983 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 262719001984 23S rRNA interface [nucleotide binding]; other site 262719001985 L3 interface [polypeptide binding]; other site 262719001986 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 262719001987 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 262719001988 S-adenosylmethionine binding site [chemical binding]; other site 262719001989 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 262719001990 active site 262719001991 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 262719001992 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 262719001993 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 262719001994 active site 262719001995 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 262719001996 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 262719001997 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 262719001998 active site 262719001999 catalytic triad [active] 262719002000 oxyanion hole [active] 262719002001 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 262719002002 AAA domain; Region: AAA_23; pfam13476 262719002003 Walker A/P-loop; other site 262719002004 ATP binding site [chemical binding]; other site 262719002005 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 262719002006 Q-loop/lid; other site 262719002007 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 262719002008 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 262719002009 Q-loop/lid; other site 262719002010 ABC transporter signature motif; other site 262719002011 Walker B; other site 262719002012 D-loop; other site 262719002013 H-loop/switch region; other site 262719002014 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 262719002015 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 262719002016 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 262719002017 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 262719002018 active site 262719002019 mycoides cluster lipoprotein, LppA/P72 family; Region: Mycoplas_LppA; TIGR03490 262719002020 mycoides cluster lipoprotein, LppA/P72 family; Region: Mycoplas_LppA; TIGR03490 262719002021 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 262719002022 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 262719002023 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 262719002024 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 262719002025 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 262719002026 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 262719002027 hypothetical protein; Provisional; Region: PRK09609 262719002028 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 262719002029 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 262719002030 active site 262719002031 HIGH motif; other site 262719002032 nucleotide binding site [chemical binding]; other site 262719002033 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 262719002034 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 262719002035 active site 262719002036 KMSKS motif; other site 262719002037 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 262719002038 tRNA binding surface [nucleotide binding]; other site 262719002039 anticodon binding site; other site 262719002040 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 262719002041 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 262719002042 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02201 262719002043 Ribonuclease P; Region: Ribonuclease_P; pfam00825 262719002044 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399