-- dump date 20140619_161404 -- class Genbank::misc_feature -- table misc_feature_note -- id note 272632000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14087 272632000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272632000003 Walker A motif; other site 272632000004 ATP binding site [chemical binding]; other site 272632000005 Walker B motif; other site 272632000006 arginine finger; other site 272632000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 272632000008 DnaA box-binding interface [nucleotide binding]; other site 272632000009 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 272632000010 DNA polymerase III beta subunit; Region: POL3Bc; smart00480 272632000011 putative DNA binding surface [nucleotide binding]; other site 272632000012 dimer interface [polypeptide binding]; other site 272632000013 beta-clamp/clamp loader binding surface; other site 272632000014 beta-clamp/translesion DNA polymerase binding surface; other site 272632000015 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 272632000016 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 272632000017 putative active site [active] 272632000018 putative metal binding site [ion binding]; other site 272632000019 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 272632000020 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272632000021 S-adenosylmethionine binding site [chemical binding]; other site 272632000022 reticulocyte binding/rhoptry protein; Region: 235kDa-fam; TIGR01612 272632000023 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 272632000024 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272632000025 ATP binding site [chemical binding]; other site 272632000026 Mg2+ binding site [ion binding]; other site 272632000027 G-X-G motif; other site 272632000028 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 272632000029 anchoring element; other site 272632000030 dimer interface [polypeptide binding]; other site 272632000031 ATP binding site [chemical binding]; other site 272632000032 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 272632000033 active site 272632000034 putative metal-binding site [ion binding]; other site 272632000035 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 272632000036 DNA gyrase subunit A; Validated; Region: PRK05560 272632000037 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 272632000038 CAP-like domain; other site 272632000039 active site 272632000040 primary dimer interface [polypeptide binding]; other site 272632000041 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272632000042 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272632000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272632000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272632000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272632000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272632000047 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 272632000048 TM-ABC transporter signature motif; other site 272632000049 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 272632000050 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 272632000051 TM-ABC transporter signature motif; other site 272632000052 Synaptonemal complex protein 1 (SCP-1); Region: SCP-1; pfam05483 272632000053 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 272632000054 Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; cl01825 272632000055 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 272632000056 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 272632000057 Walker A/P-loop; other site 272632000058 ATP binding site [chemical binding]; other site 272632000059 Q-loop/lid; other site 272632000060 ABC transporter signature motif; other site 272632000061 Walker B; other site 272632000062 D-loop; other site 272632000063 H-loop/switch region; other site 272632000064 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 272632000065 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 272632000066 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 272632000067 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 272632000068 active site 272632000069 HIGH motif; other site 272632000070 KMSKS motif; other site 272632000071 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 272632000072 tRNA binding surface [nucleotide binding]; other site 272632000073 anticodon binding site; other site 272632000074 mycoides cluster lipoprotein, LppA/P72 family; Region: Mycoplas_LppA; TIGR03490 272632000075 mycoides cluster lipoprotein, LppA/P72 family; Region: Mycoplas_LppA; TIGR03490 272632000076 CD99 antigen like protein 2; Region: CD99L2; pfam12301 272632000077 putative transposase OrfB; Reviewed; Region: PHA02517 272632000078 HTH-like domain; Region: HTH_21; pfam13276 272632000079 Integrase core domain; Region: rve; pfam00665 272632000080 Integrase core domain; Region: rve_2; pfam13333 272632000081 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272632000082 Helix-turn-helix domain; Region: HTH_28; pfam13518 272632000083 Helix-turn-helix domain; Region: HTH_28; pfam13518 272632000084 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 272632000085 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 272632000086 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272632000087 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272632000088 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272632000089 putative active site [active] 272632000090 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 272632000091 active site 272632000092 phosphorylation site [posttranslational modification] 272632000093 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 272632000094 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 272632000095 putative NAD(P) binding site [chemical binding]; other site 272632000096 active site 272632000097 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 272632000098 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 272632000099 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 272632000100 active site 272632000101 P-loop; other site 272632000102 phosphorylation site [posttranslational modification] 272632000103 MarR family; Region: MarR_2; pfam12802 272632000104 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 272632000105 Divergent AAA domain; Region: AAA_4; pfam04326 272632000106 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 272632000107 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 272632000108 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 272632000109 dimer interface [polypeptide binding]; other site 272632000110 ssDNA binding site [nucleotide binding]; other site 272632000111 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272632000112 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 272632000113 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 272632000114 DNA-binding site [nucleotide binding]; DNA binding site 272632000115 RNA-binding motif; other site 272632000116 azoreductase; Reviewed; Region: PRK01355 272632000117 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272632000118 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272632000119 Walker A/P-loop; other site 272632000120 ATP binding site [chemical binding]; other site 272632000121 Q-loop/lid; other site 272632000122 ABC transporter signature motif; other site 272632000123 Walker B; other site 272632000124 D-loop; other site 272632000125 H-loop/switch region; other site 272632000126 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 272632000127 Hsp33 protein; Region: HSP33; pfam01430 272632000128 dimerization interface [polypeptide binding]; other site 272632000129 domain crossover interface; other site 272632000130 redox-dependent activation switch; other site 272632000131 GnsA/GnsB family; Region: GnsAB; pfam08178 272632000132 FtsX-like permease family; Region: FtsX; pfam02687 272632000133 FtsX-like permease family; Region: FtsX; pfam02687 272632000134 (R)-2-Hydroxyglutarate Dehydrogenase and related dehydrogenases, NAD-binding and catalytic domains; Region: HGDH_like; cd12184 272632000135 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 272632000136 putative homodimer interface [polypeptide binding]; other site 272632000137 putative ligand binding site [chemical binding]; other site 272632000138 putative NAD binding site [chemical binding]; other site 272632000139 catalytic site [active] 272632000140 Membrane transport protein; Region: Mem_trans; cl09117 272632000141 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 272632000142 AAA domain; Region: AAA_14; pfam13173 272632000143 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 272632000144 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 272632000145 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272632000146 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 272632000147 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 272632000148 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272632000149 Walker A motif; other site 272632000150 ATP binding site [chemical binding]; other site 272632000151 Walker B motif; other site 272632000152 arginine finger; other site 272632000153 Peptidase family M41; Region: Peptidase_M41; pfam01434 272632000154 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 272632000155 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 272632000156 Ligand Binding Site [chemical binding]; other site 272632000157 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272632000158 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272632000159 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 272632000160 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 272632000161 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272632000162 S-adenosylmethionine binding site [chemical binding]; other site 272632000163 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 272632000164 DNA polymerase III subunit delta'; Validated; Region: PRK08485 272632000165 thymidylate kinase; Validated; Region: tmk; PRK00698 272632000166 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 272632000167 TMP-binding site; other site 272632000168 ATP-binding site [chemical binding]; other site 272632000169 RecR protein; Region: RecR; pfam02132 272632000170 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 272632000171 active site 272632000172 metal binding site [ion binding]; metal-binding site 272632000173 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 272632000174 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272632000175 Walker A motif; other site 272632000176 ATP binding site [chemical binding]; other site 272632000177 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 272632000178 Walker B motif; other site 272632000179 arginine finger; other site 272632000180 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 272632000181 nucleoside/Zn binding site; other site 272632000182 dimer interface [polypeptide binding]; other site 272632000183 catalytic motif [active] 272632000184 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 272632000185 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 272632000186 active site 272632000187 Uncharacterized conserved protein [Function unknown]; Region: COG2433 272632000188 Putative peptidase (DUF31); Region: DUF31; pfam01732 272632000189 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 272632000190 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 272632000191 catalytic triad [active] 272632000192 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 272632000193 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272632000194 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272632000195 active site turn [active] 272632000196 phosphorylation site [posttranslational modification] 272632000197 putative transposase OrfB; Reviewed; Region: PHA02517 272632000198 HTH-like domain; Region: HTH_21; pfam13276 272632000199 Integrase core domain; Region: rve; pfam00665 272632000200 Integrase core domain; Region: rve_2; pfam13333 272632000201 Helix-turn-helix domain; Region: HTH_28; pfam13518 272632000202 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272632000203 Helix-turn-helix domain; Region: HTH_28; pfam13518 272632000204 Transposase [DNA replication, recombination, and repair]; Region: COG5421 272632000205 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 272632000206 Protein of unknown function (DUF3816); Region: DUF3816; cl17272 272632000207 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 272632000208 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 272632000209 hexamer interface [polypeptide binding]; other site 272632000210 ligand binding site [chemical binding]; other site 272632000211 putative active site [active] 272632000212 NAD(P) binding site [chemical binding]; other site 272632000213 Predicted membrane protein [Function unknown]; Region: COG2364 272632000214 seryl-tRNA synthetase; Provisional; Region: PRK05431 272632000215 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 272632000216 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 272632000217 dimer interface [polypeptide binding]; other site 272632000218 active site 272632000219 motif 1; other site 272632000220 motif 2; other site 272632000221 motif 3; other site 272632000222 Domain of unknown function (DUF1904); Region: DUF1904; pfam08921 272632000223 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 272632000224 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 272632000225 FMN binding site [chemical binding]; other site 272632000226 active site 272632000227 catalytic residues [active] 272632000228 substrate binding site [chemical binding]; other site 272632000229 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 272632000230 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 272632000231 dimer interface [polypeptide binding]; other site 272632000232 putative anticodon binding site; other site 272632000233 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 272632000234 motif 1; other site 272632000235 active site 272632000236 motif 2; other site 272632000237 motif 3; other site 272632000238 Transposase [DNA replication, recombination, and repair]; Region: COG5421 272632000239 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272632000240 catalytic residues [active] 272632000241 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 272632000242 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272632000243 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272632000244 active site 272632000245 motif I; other site 272632000246 motif II; other site 272632000247 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272632000248 Transposase [DNA replication, recombination, and repair]; Region: COG5421 272632000249 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 272632000250 Competence protein; Region: Competence; cl00471 272632000251 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 272632000252 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 272632000253 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 272632000254 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272632000255 dimer interface [polypeptide binding]; other site 272632000256 conserved gate region; other site 272632000257 putative PBP binding loops; other site 272632000258 ABC-ATPase subunit interface; other site 272632000259 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272632000260 dimer interface [polypeptide binding]; other site 272632000261 conserved gate region; other site 272632000262 putative PBP binding loops; other site 272632000263 ABC-ATPase subunit interface; other site 272632000264 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 272632000265 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 272632000266 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 272632000267 Walker A/P-loop; other site 272632000268 ATP binding site [chemical binding]; other site 272632000269 Q-loop/lid; other site 272632000270 ABC transporter signature motif; other site 272632000271 Walker B; other site 272632000272 D-loop; other site 272632000273 H-loop/switch region; other site 272632000274 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 272632000275 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 272632000276 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 272632000277 putative dimer interface [polypeptide binding]; other site 272632000278 putative anticodon binding site; other site 272632000279 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 272632000280 homodimer interface [polypeptide binding]; other site 272632000281 motif 1; other site 272632000282 motif 2; other site 272632000283 active site 272632000284 motif 3; other site 272632000285 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 272632000286 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272632000287 active site 272632000288 motif I; other site 272632000289 motif II; other site 272632000290 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272632000291 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272632000292 UGMP family protein; Validated; Region: PRK09604 272632000293 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 272632000294 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 272632000295 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 272632000296 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 272632000297 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 272632000298 trmE is a tRNA modification GTPase; Region: trmE; cd04164 272632000299 G1 box; other site 272632000300 GTP/Mg2+ binding site [chemical binding]; other site 272632000301 Switch I region; other site 272632000302 G2 box; other site 272632000303 Switch II region; other site 272632000304 G3 box; other site 272632000305 G4 box; other site 272632000306 G5 box; other site 272632000307 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 272632000308 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 272632000309 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12903 272632000310 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 272632000311 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272632000312 nucleotide binding region [chemical binding]; other site 272632000313 ATP-binding site [chemical binding]; other site 272632000314 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 272632000315 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 272632000316 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 272632000317 5'-3' exonuclease; Region: 53EXOc; smart00475 272632000318 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 272632000319 active site 272632000320 metal binding site 1 [ion binding]; metal-binding site 272632000321 putative 5' ssDNA interaction site; other site 272632000322 metal binding site 3; metal-binding site 272632000323 metal binding site 2 [ion binding]; metal-binding site 272632000324 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 272632000325 putative DNA binding site [nucleotide binding]; other site 272632000326 putative metal binding site [ion binding]; other site 272632000327 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 272632000328 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 272632000329 AAA domain; Region: AAA_14; pfam13173 272632000330 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 272632000331 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 272632000332 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 272632000333 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 272632000334 CoA-binding site [chemical binding]; other site 272632000335 ATP-binding [chemical binding]; other site 272632000336 Transposase [DNA replication, recombination, and repair]; Region: COG5421 272632000337 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 272632000338 Transposase [DNA replication, recombination, and repair]; Region: COG5421 272632000339 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 272632000340 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272632000341 RNA binding surface [nucleotide binding]; other site 272632000342 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 272632000343 Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609 272632000344 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 272632000345 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 272632000346 generic binding surface II; other site 272632000347 generic binding surface I; other site 272632000348 transcription antitermination factor NusB; Region: nusB; TIGR01951 272632000349 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 272632000350 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 272632000351 AP (apurinic/apyrimidinic) site pocket; other site 272632000352 DNA interaction; other site 272632000353 Metal-binding active site; metal-binding site 272632000354 Riboflavin kinase; Region: Flavokinase; smart00904 272632000355 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 272632000356 Active site serine [active] 272632000357 Pox virus Ag35 surface protein; Region: Pox_Ag35; pfam03286 272632000358 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272632000359 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 272632000360 DXD motif; other site 272632000361 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272632000362 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272632000363 active site 272632000364 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 272632000365 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 272632000366 active site 272632000367 tetramer interface; other site 272632000368 membrane protein; Provisional; Region: PRK14399 272632000369 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 272632000370 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272632000371 AAA domain; Region: AAA_17; pfam13207 272632000372 ABC transporter; Region: ABC_tran_2; pfam12848 272632000373 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272632000374 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 272632000375 tetramer interface [polypeptide binding]; other site 272632000376 cysteine synthase; Region: PLN02565 272632000377 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272632000378 catalytic residue [active] 272632000379 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 272632000380 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272632000381 Mycoplasma MFS transporter; Region: MFS_Mycoplasma; pfam07672 272632000382 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272632000383 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 272632000384 active site 272632000385 trimer interface [polypeptide binding]; other site 272632000386 allosteric site; other site 272632000387 active site lid [active] 272632000388 hexamer (dimer of trimers) interface [polypeptide binding]; other site 272632000389 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272632000390 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 272632000391 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272632000392 active site turn [active] 272632000393 phosphorylation site [posttranslational modification] 272632000394 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 272632000395 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 272632000396 active site 272632000397 HIGH motif; other site 272632000398 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 272632000399 KMSKS motif; other site 272632000400 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 272632000401 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272632000402 Zn2+ binding site [ion binding]; other site 272632000403 Mg2+ binding site [ion binding]; other site 272632000404 DNA-directed RNA polymerase subunit delta; Reviewed; Region: PRK02363 272632000405 CTP synthetase; Validated; Region: pyrG; PRK05380 272632000406 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 272632000407 Catalytic site [active] 272632000408 active site 272632000409 UTP binding site [chemical binding]; other site 272632000410 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 272632000411 active site 272632000412 putative oxyanion hole; other site 272632000413 catalytic triad [active] 272632000414 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 272632000415 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 272632000416 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 272632000417 putative transposase OrfB; Reviewed; Region: PHA02517 272632000418 HTH-like domain; Region: HTH_21; pfam13276 272632000419 Integrase core domain; Region: rve; pfam00665 272632000420 Integrase core domain; Region: rve_2; pfam13333 272632000421 Helix-turn-helix domain; Region: HTH_28; pfam13518 272632000422 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272632000423 Helix-turn-helix domain; Region: HTH_28; pfam13518 272632000424 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 272632000425 intersubunit interface [polypeptide binding]; other site 272632000426 active site 272632000427 zinc binding site [ion binding]; other site 272632000428 Na+ binding site [ion binding]; other site 272632000429 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272632000430 Helix-turn-helix domain; Region: HTH_28; pfam13518 272632000431 Helix-turn-helix domain; Region: HTH_28; pfam13518 272632000432 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 272632000433 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 272632000434 active site 272632000435 catalytic site [active] 272632000436 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 272632000437 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 272632000438 DHH family; Region: DHH; pfam01368 272632000439 DHHA1 domain; Region: DHHA1; pfam02272 272632000440 thymidine kinase; Provisional; Region: PRK04296 272632000441 peptide chain release factor 1; Validated; Region: prfA; PRK00591 272632000442 This domain is found in peptide chain release factors; Region: PCRF; smart00937 272632000443 RF-1 domain; Region: RF-1; pfam00472 272632000444 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 272632000445 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272632000446 S-adenosylmethionine binding site [chemical binding]; other site 272632000447 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 272632000448 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 272632000449 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 272632000450 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 272632000451 putative active site [active] 272632000452 catalytic site [active] 272632000453 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 272632000454 putative active site [active] 272632000455 catalytic site [active] 272632000456 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 272632000457 S17 interaction site [polypeptide binding]; other site 272632000458 S8 interaction site; other site 272632000459 16S rRNA interaction site [nucleotide binding]; other site 272632000460 streptomycin interaction site [chemical binding]; other site 272632000461 23S rRNA interaction site [nucleotide binding]; other site 272632000462 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 272632000463 30S ribosomal protein S7; Validated; Region: PRK05302 272632000464 elongation factor G; Reviewed; Region: PRK00007 272632000465 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 272632000466 G1 box; other site 272632000467 putative GEF interaction site [polypeptide binding]; other site 272632000468 GTP/Mg2+ binding site [chemical binding]; other site 272632000469 Switch I region; other site 272632000470 G2 box; other site 272632000471 G3 box; other site 272632000472 Switch II region; other site 272632000473 G4 box; other site 272632000474 G5 box; other site 272632000475 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 272632000476 Elongation Factor G, domain II; Region: EFG_II; pfam14492 272632000477 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 272632000478 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 272632000479 elongation factor Tu; Reviewed; Region: PRK00049 272632000480 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 272632000481 G1 box; other site 272632000482 GEF interaction site [polypeptide binding]; other site 272632000483 GTP/Mg2+ binding site [chemical binding]; other site 272632000484 Switch I region; other site 272632000485 G2 box; other site 272632000486 G3 box; other site 272632000487 Switch II region; other site 272632000488 G4 box; other site 272632000489 G5 box; other site 272632000490 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 272632000491 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 272632000492 Antibiotic Binding Site [chemical binding]; other site 272632000493 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 272632000494 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 272632000495 Glycosyl hydrolases family 31; Region: Glyco_hydro_31; pfam01055 272632000496 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 272632000497 active site 272632000498 homotrimer interface [polypeptide binding]; other site 272632000499 catalytic site [active] 272632000500 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 272632000501 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 272632000502 interface (dimer of trimers) [polypeptide binding]; other site 272632000503 Substrate-binding/catalytic site; other site 272632000504 Zn-binding sites [ion binding]; other site 272632000505 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272632000506 S-adenosylmethionine binding site [chemical binding]; other site 272632000507 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 272632000508 MgtE intracellular N domain; Region: MgtE_N; pfam03448 272632000509 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 272632000510 Divalent cation transporter; Region: MgtE; cl00786 272632000511 Transposase [DNA replication, recombination, and repair]; Region: COG5421 272632000512 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 272632000513 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 272632000514 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272632000515 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 272632000516 Helix-turn-helix domain; Region: HTH_28; pfam13518 272632000517 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272632000518 Helix-turn-helix domain; Region: HTH_28; pfam13518 272632000519 putative transposase OrfB; Reviewed; Region: PHA02517 272632000520 HTH-like domain; Region: HTH_21; pfam13276 272632000521 Integrase core domain; Region: rve; pfam00665 272632000522 Integrase core domain; Region: rve_2; pfam13333 272632000523 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 272632000524 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 272632000525 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 272632000526 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 272632000527 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 272632000528 motif 1; other site 272632000529 active site 272632000530 motif 2; other site 272632000531 motif 3; other site 272632000532 Protein of unknown function (DUF1186); Region: DUF1186; pfam06685 272632000533 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 272632000534 Peptidase family M48; Region: Peptidase_M48; cl12018 272632000535 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272632000536 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272632000537 dimer interface [polypeptide binding]; other site 272632000538 conserved gate region; other site 272632000539 putative PBP binding loops; other site 272632000540 ABC-ATPase subunit interface; other site 272632000541 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 272632000542 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272632000543 dimer interface [polypeptide binding]; other site 272632000544 conserved gate region; other site 272632000545 ABC-ATPase subunit interface; other site 272632000546 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 272632000547 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272632000548 Walker A/P-loop; other site 272632000549 ATP binding site [chemical binding]; other site 272632000550 FlxA-like protein; Region: FlxA; pfam14282 272632000551 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272632000552 Q-loop/lid; other site 272632000553 ABC transporter signature motif; other site 272632000554 Walker B; other site 272632000555 D-loop; other site 272632000556 H-loop/switch region; other site 272632000557 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272632000558 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 272632000559 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272632000560 Walker A/P-loop; other site 272632000561 ATP binding site [chemical binding]; other site 272632000562 Q-loop/lid; other site 272632000563 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272632000564 Q-loop/lid; other site 272632000565 ABC transporter signature motif; other site 272632000566 Walker B; other site 272632000567 D-loop; other site 272632000568 H-loop/switch region; other site 272632000569 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272632000570 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 272632000571 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 272632000572 ApaLI-like restriction endonuclease; Region: RE_ApaLI; pfam09499 272632000573 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 272632000574 DNA methylase; Region: N6_N4_Mtase; pfam01555 272632000575 e3 binding domain; Region: E3_binding; pfam02817 272632000576 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 272632000577 AAA-like domain; Region: AAA_10; pfam12846 272632000578 Helix-turn-helix domain; Region: HTH_17; pfam12728 272632000579 Fic family protein [Function unknown]; Region: COG3177 272632000580 Fic/DOC family; Region: Fic; pfam02661 272632000581 Uncharacterized phage-associated protein [Function unknown]; Region: GepA; COG3600 272632000582 sporozoite surface protein 2 (SSP2); Provisional; Region: PTZ00441 272632000583 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 272632000584 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 272632000585 Holliday junction DNA helicase, RuvB subunit; Region: ruvB; TIGR00635 272632000586 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 272632000587 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 272632000588 DNA polymerase III PolC; Validated; Region: polC; PRK00448 272632000589 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 272632000590 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 272632000591 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 272632000592 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 272632000593 DNA sequence specific (IHF) and non-specific (HU) domains; Region: HU_IHF; cl00257 272632000594 putative transposase OrfB; Reviewed; Region: PHA02517 272632000595 HTH-like domain; Region: HTH_21; pfam13276 272632000596 Integrase core domain; Region: rve; pfam00665 272632000597 Integrase core domain; Region: rve_2; pfam13333 272632000598 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 272632000599 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 272632000600 G1 box; other site 272632000601 putative GEF interaction site [polypeptide binding]; other site 272632000602 GTP/Mg2+ binding site [chemical binding]; other site 272632000603 Switch I region; other site 272632000604 G2 box; other site 272632000605 G3 box; other site 272632000606 Switch II region; other site 272632000607 G4 box; other site 272632000608 G5 box; other site 272632000609 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 272632000610 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 272632000611 Eco47II restriction endonuclease; Region: RE_Eco47II; pfam09553 272632000612 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 272632000613 cofactor binding site; other site 272632000614 DNA binding site [nucleotide binding] 272632000615 substrate interaction site [chemical binding]; other site 272632000616 16S rRNA methyltransferase B; Provisional; Region: PRK14902 272632000617 NusB family; Region: NusB; pfam01029 272632000618 putative RNA binding site [nucleotide binding]; other site 272632000619 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272632000620 S-adenosylmethionine binding site [chemical binding]; other site 272632000621 Guanylate kinase; Region: Guanylate_kin; pfam00625 272632000622 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 272632000623 catalytic site [active] 272632000624 G-X2-G-X-G-K; other site 272632000625 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272632000626 S-adenosylmethionine binding site [chemical binding]; other site 272632000627 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 272632000628 active site 272632000629 catalytic residues [active] 272632000630 metal binding site [ion binding]; metal-binding site 272632000631 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 272632000632 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 272632000633 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 272632000634 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 272632000635 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 272632000636 23S rRNA binding site [nucleotide binding]; other site 272632000637 L21 binding site [polypeptide binding]; other site 272632000638 L13 binding site [polypeptide binding]; other site 272632000639 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 272632000640 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 272632000641 Walker A/P-loop; other site 272632000642 ATP binding site [chemical binding]; other site 272632000643 Q-loop/lid; other site 272632000644 ABC transporter signature motif; other site 272632000645 Walker B; other site 272632000646 D-loop; other site 272632000647 H-loop/switch region; other site 272632000648 TOBE domain; Region: TOBE_2; pfam08402 272632000649 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 272632000650 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272632000651 dimer interface [polypeptide binding]; other site 272632000652 conserved gate region; other site 272632000653 putative PBP binding loops; other site 272632000654 ABC-ATPase subunit interface; other site 272632000655 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 272632000656 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272632000657 dimer interface [polypeptide binding]; other site 272632000658 conserved gate region; other site 272632000659 putative PBP binding loops; other site 272632000660 ABC-ATPase subunit interface; other site 272632000661 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 272632000662 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 272632000663 Abi-like protein; Region: Abi_2; pfam07751 272632000664 Chromate transporter; Region: Chromate_transp; cl17781 272632000665 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272632000666 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272632000667 Helix-turn-helix domain; Region: HTH_28; pfam13518 272632000668 Helix-turn-helix domain; Region: HTH_28; pfam13518 272632000669 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 272632000670 AAA domain; Region: AAA_14; pfam13173 272632000671 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 272632000672 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 272632000673 interface (dimer of trimers) [polypeptide binding]; other site 272632000674 Substrate-binding/catalytic site; other site 272632000675 Zn-binding sites [ion binding]; other site 272632000676 oligoendopeptidase F; Region: pepF; TIGR00181 272632000677 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 272632000678 active site 272632000679 Zn binding site [ion binding]; other site 272632000680 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272632000681 Helix-turn-helix domain; Region: HTH_28; pfam13518 272632000682 Helix-turn-helix domain; Region: HTH_28; pfam13518 272632000683 putative transposase OrfB; Reviewed; Region: PHA02517 272632000684 HTH-like domain; Region: HTH_21; pfam13276 272632000685 Integrase core domain; Region: rve; pfam00665 272632000686 Integrase core domain; Region: rve_2; pfam13333 272632000687 mycoides cluster lipoprotein, LppA/P72 family; Region: Mycoplas_LppA; TIGR03490 272632000688 Selenoprotein P, N terminal region; Region: SelP_N; pfam04592 272632000689 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 272632000690 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272632000691 active site 272632000692 motif I; other site 272632000693 motif II; other site 272632000694 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272632000695 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 272632000696 AAA domain; Region: AAA_14; pfam13173 272632000697 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 272632000698 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 272632000699 Transposase [DNA replication, recombination, and repair]; Region: COG5421 272632000700 putative transposase OrfB; Reviewed; Region: PHA02517 272632000701 HTH-like domain; Region: HTH_21; pfam13276 272632000702 Integrase core domain; Region: rve; pfam00665 272632000703 Integrase core domain; Region: rve_2; pfam13333 272632000704 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 272632000705 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 272632000706 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 272632000707 putative active site [active] 272632000708 Transposase [DNA replication, recombination, and repair]; Region: COG5421 272632000709 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 272632000710 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 272632000711 active site turn [active] 272632000712 phosphorylation site [posttranslational modification] 272632000713 PTS system, glucose-like IIB component; Region: EIIB_glc; TIGR00826 272632000714 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272632000715 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 272632000716 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 272632000717 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272632000718 putative active site [active] 272632000719 enolase; Provisional; Region: eno; PRK00077 272632000720 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 272632000721 dimer interface [polypeptide binding]; other site 272632000722 metal binding site [ion binding]; metal-binding site 272632000723 substrate binding pocket [chemical binding]; other site 272632000724 PAP2_like_6 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which mainly contains bacterial proteins, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_6; cd03396 272632000725 active site 272632000726 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 272632000727 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272632000728 active site 272632000729 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 272632000730 amphipathic channel; other site 272632000731 Asn-Pro-Ala signature motifs; other site 272632000732 glycerol kinase; Provisional; Region: glpK; PRK00047 272632000733 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 272632000734 N- and C-terminal domain interface [polypeptide binding]; other site 272632000735 active site 272632000736 MgATP binding site [chemical binding]; other site 272632000737 catalytic site [active] 272632000738 metal binding site [ion binding]; metal-binding site 272632000739 glycerol binding site [chemical binding]; other site 272632000740 homotetramer interface [polypeptide binding]; other site 272632000741 homodimer interface [polypeptide binding]; other site 272632000742 FBP binding site [chemical binding]; other site 272632000743 protein IIAGlc interface [polypeptide binding]; other site 272632000744 hydroxyglutarate oxidase; Provisional; Region: PRK11728; cl19156 272632000745 FAD dependent oxidoreductase; Region: DAO; pfam01266 272632000746 6-phosphofructokinase; Provisional; Region: PRK03202 272632000747 active site 272632000748 ADP/pyrophosphate binding site [chemical binding]; other site 272632000749 dimerization interface [polypeptide binding]; other site 272632000750 allosteric effector site; other site 272632000751 fructose-1,6-bisphosphate binding site; other site 272632000752 pyruvate kinase; Provisional; Region: PRK05826 272632000753 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 272632000754 domain interfaces; other site 272632000755 active site 272632000756 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 272632000757 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 272632000758 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 272632000759 active site 272632000760 dimer interface [polypeptide binding]; other site 272632000761 motif 1; other site 272632000762 motif 2; other site 272632000763 motif 3; other site 272632000764 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 272632000765 anticodon binding site; other site 272632000766 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 272632000767 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272632000768 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272632000769 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 272632000770 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 272632000771 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 272632000772 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 272632000773 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 272632000774 tetramer interface [polypeptide binding]; other site 272632000775 TPP-binding site [chemical binding]; other site 272632000776 heterodimer interface [polypeptide binding]; other site 272632000777 phosphorylation loop region [posttranslational modification] 272632000778 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 272632000779 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 272632000780 alpha subunit interface [polypeptide binding]; other site 272632000781 TPP binding site [chemical binding]; other site 272632000782 heterodimer interface [polypeptide binding]; other site 272632000783 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272632000784 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 272632000785 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272632000786 E3 interaction surface; other site 272632000787 lipoyl attachment site [posttranslational modification]; other site 272632000788 e3 binding domain; Region: E3_binding; pfam02817 272632000789 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 272632000790 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272632000791 E3 interaction surface; other site 272632000792 lipoyl attachment site [posttranslational modification]; other site 272632000793 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 272632000794 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272632000795 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272632000796 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 272632000797 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; pfam01515 272632000798 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 272632000799 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272632000800 nucleotide binding site [chemical binding]; other site 272632000801 Putative peptidase (DUF31); Region: DUF31; pfam01732 272632000802 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK13964 272632000803 active site 272632000804 nucleotide binding site [chemical binding]; other site 272632000805 HIGH motif; other site 272632000806 KMSKS motif; other site 272632000807 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 272632000808 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 272632000809 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 272632000810 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 272632000811 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 272632000812 HPr interaction site; other site 272632000813 glycerol kinase (GK) interaction site [polypeptide binding]; other site 272632000814 active site 272632000815 phosphorylation site [posttranslational modification] 272632000816 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 272632000817 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 272632000818 active pocket/dimerization site; other site 272632000819 active site 272632000820 phosphorylation site [posttranslational modification] 272632000821 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 272632000822 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 272632000823 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272632000824 RNA binding surface [nucleotide binding]; other site 272632000825 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 272632000826 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 272632000827 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 272632000828 Ligand Binding Site [chemical binding]; other site 272632000829 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 272632000830 Active site serine [active] 272632000831 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 272632000832 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 272632000833 Protein of unknown function (DUF342); Region: DUF342; cl19219 272632000834 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 272632000835 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl19164 272632000836 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 272632000837 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 272632000838 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272632000839 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 272632000840 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 272632000841 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 272632000842 Predicted GTPase [General function prediction only]; Region: COG0218 272632000843 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 272632000844 G1 box; other site 272632000845 GTP/Mg2+ binding site [chemical binding]; other site 272632000846 Switch I region; other site 272632000847 G2 box; other site 272632000848 G3 box; other site 272632000849 Switch II region; other site 272632000850 G4 box; other site 272632000851 G5 box; other site 272632000852 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 272632000853 classical (c) SDRs; Region: SDR_c; cd05233 272632000854 NAD(P) binding site [chemical binding]; other site 272632000855 active site 272632000856 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 272632000857 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 272632000858 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 272632000859 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 272632000860 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 272632000861 GIY-YIG motif/motif A; other site 272632000862 active site 272632000863 catalytic site [active] 272632000864 putative DNA binding site [nucleotide binding]; other site 272632000865 metal binding site [ion binding]; metal-binding site 272632000866 UvrB/uvrC motif; Region: UVR; pfam02151 272632000867 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 272632000868 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 272632000869 PAP2 superfamily; Region: PAP2; pfam01569 272632000870 Amino acid permease; Region: AA_permease; pfam00324 272632000871 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 272632000872 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272632000873 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 272632000874 classical (c) SDRs; Region: SDR_c; cd05233 272632000875 NAD(P) binding site [chemical binding]; other site 272632000876 active site 272632000877 ATP-NAD kinase; Region: NAD_kinase; cl01255 272632000878 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 272632000879 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 272632000880 active site 272632000881 HIGH motif; other site 272632000882 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 272632000883 KMSKS motif; other site 272632000884 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 272632000885 tRNA binding surface [nucleotide binding]; other site 272632000886 anticodon binding site; other site 272632000887 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 272632000888 Thiamine pyrophosphokinase; Region: TPK; cd07995 272632000889 active site 272632000890 dimerization interface [polypeptide binding]; other site 272632000891 thiamine binding site [chemical binding]; other site 272632000892 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 272632000893 substrate binding site [chemical binding]; other site 272632000894 hexamer interface [polypeptide binding]; other site 272632000895 metal binding site [ion binding]; metal-binding site 272632000896 GTPase RsgA; Reviewed; Region: PRK00098 272632000897 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 272632000898 RNA binding site [nucleotide binding]; other site 272632000899 homodimer interface [polypeptide binding]; other site 272632000900 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 272632000901 GTPase/Zn-binding domain interface [polypeptide binding]; other site 272632000902 GTP/Mg2+ binding site [chemical binding]; other site 272632000903 G4 box; other site 272632000904 G5 box; other site 272632000905 G1 box; other site 272632000906 Switch I region; other site 272632000907 G2 box; other site 272632000908 G3 box; other site 272632000909 Switch II region; other site 272632000910 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272632000911 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272632000912 active site 272632000913 ATP binding site [chemical binding]; other site 272632000914 substrate binding site [chemical binding]; other site 272632000915 activation loop (A-loop); other site 272632000916 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 272632000917 active site 272632000918 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 272632000919 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 272632000920 FtsX-like permease family; Region: FtsX; pfam02687 272632000921 aromatic cluster surface protein; Region: aro_clust_Mycop; TIGR04313 272632000922 aromatic cluster surface protein; Region: aro_clust_Mycop; TIGR04313 272632000923 aromatic cluster surface protein; Region: aro_clust_Mycop; TIGR04313 272632000924 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 272632000925 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272632000926 Walker A/P-loop; other site 272632000927 ATP binding site [chemical binding]; other site 272632000928 Q-loop/lid; other site 272632000929 ABC transporter signature motif; other site 272632000930 Walker B; other site 272632000931 D-loop; other site 272632000932 H-loop/switch region; other site 272632000933 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 272632000934 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 272632000935 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 272632000936 prolyl-tRNA synthetase; Provisional; Region: PRK08661 272632000937 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 272632000938 dimer interface [polypeptide binding]; other site 272632000939 motif 1; other site 272632000940 active site 272632000941 motif 2; other site 272632000942 motif 3; other site 272632000943 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 272632000944 anticodon binding site; other site 272632000945 Predicted double-stranded RNA/RNA-DNA hybrid binding protein [General function prediction only]; Region: COG3341 272632000946 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 272632000947 Bacterial RNase HI containing a hybrid binding domain (HBD) at the N-terminus; Region: RNase_HI_bacteria_like; cd09277 272632000948 RNA/DNA hybrid binding site [nucleotide binding]; other site 272632000949 active site 272632000950 GTP-binding protein LepA; Provisional; Region: PRK05433 272632000951 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 272632000952 G1 box; other site 272632000953 putative GEF interaction site [polypeptide binding]; other site 272632000954 GTP/Mg2+ binding site [chemical binding]; other site 272632000955 Switch I region; other site 272632000956 G2 box; other site 272632000957 G3 box; other site 272632000958 Switch II region; other site 272632000959 G4 box; other site 272632000960 G5 box; other site 272632000961 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 272632000962 Elongation Factor G, domain II; Region: EFG_II; pfam14492 272632000963 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 272632000964 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 272632000965 Transposase [DNA replication, recombination, and repair]; Region: COG5421 272632000966 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 272632000967 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 272632000968 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 272632000969 dimer interface [polypeptide binding]; other site 272632000970 anticodon binding site; other site 272632000971 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 272632000972 homodimer interface [polypeptide binding]; other site 272632000973 motif 1; other site 272632000974 active site 272632000975 motif 2; other site 272632000976 GAD domain; Region: GAD; pfam02938 272632000977 motif 3; other site 272632000978 histidyl-tRNA synthetase; Region: hisS; TIGR00442 272632000979 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 272632000980 dimer interface [polypeptide binding]; other site 272632000981 motif 1; other site 272632000982 active site 272632000983 motif 2; other site 272632000984 motif 3; other site 272632000985 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 272632000986 anticodon binding site; other site 272632000987 Ribosome-binding factor A; Region: RBFA; pfam02033 272632000988 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 272632000989 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 272632000990 RNA binding site [nucleotide binding]; other site 272632000991 active site 272632000992 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272632000993 active site 272632000994 nucleotide binding site [chemical binding]; other site 272632000995 HIGH motif; other site 272632000996 KMSKS motif; other site 272632000997 Transposase [DNA replication, recombination, and repair]; Region: COG5421 272632000998 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 272632000999 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 272632001000 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 272632001001 Active site serine [active] 272632001002 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 272632001003 16S/18S rRNA binding site [nucleotide binding]; other site 272632001004 S13e-L30e interaction site [polypeptide binding]; other site 272632001005 25S rRNA binding site [nucleotide binding]; other site 272632001006 translation initiation factor IF-2; Region: IF-2; TIGR00487 272632001007 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 272632001008 G1 box; other site 272632001009 putative GEF interaction site [polypeptide binding]; other site 272632001010 GTP/Mg2+ binding site [chemical binding]; other site 272632001011 Switch I region; other site 272632001012 G2 box; other site 272632001013 G3 box; other site 272632001014 Switch II region; other site 272632001015 G4 box; other site 272632001016 G5 box; other site 272632001017 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 272632001018 Translation-initiation factor 2; Region: IF-2; pfam11987 272632001019 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 272632001020 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 272632001021 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 272632001022 putative RNA binding cleft [nucleotide binding]; other site 272632001023 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 272632001024 NusA N-terminal domain; Region: NusA_N; pfam08529 272632001025 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 272632001026 RNA binding site [nucleotide binding]; other site 272632001027 homodimer interface [polypeptide binding]; other site 272632001028 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 272632001029 G-X-X-G motif; other site 272632001030 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 272632001031 G-X-X-G motif; other site 272632001032 Sm and related proteins; Region: Sm_like; cl00259 272632001033 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 272632001034 putative oligomer interface [polypeptide binding]; other site 272632001035 putative RNA binding site [nucleotide binding]; other site 272632001036 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 272632001037 dimer interface [polypeptide binding]; other site 272632001038 FMN binding site [chemical binding]; other site 272632001039 DNA polymerase III PolC; Validated; Region: polC; PRK00448 272632001040 DNA polymerase III polC-type N-terminus I; Region: DNA_pol3_a_NI; pfam14480 272632001041 DNA polymerase III polC-type N-terminus II; Region: DNA_pol3_a_NII; pfam11490 272632001042 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 272632001043 generic binding surface II; other site 272632001044 generic binding surface I; other site 272632001045 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 272632001046 active site 272632001047 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 272632001048 active site 272632001049 catalytic site [active] 272632001050 substrate binding site [chemical binding]; other site 272632001051 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 272632001052 putative PHP Thumb interface [polypeptide binding]; other site 272632001053 active site 272632001054 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 272632001055 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl19066 272632001056 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 272632001057 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 272632001058 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 272632001059 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 272632001060 active site 272632001061 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 272632001062 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 272632001063 active site 272632001064 HIGH motif; other site 272632001065 dimer interface [polypeptide binding]; other site 272632001066 KMSKS motif; other site 272632001067 RmuC family; Region: RmuC; pfam02646 272632001068 Transposase [DNA replication, recombination, and repair]; Region: COG5421 272632001069 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 272632001070 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272632001071 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 272632001072 nucleophilic elbow; other site 272632001073 catalytic triad; other site 272632001074 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 272632001075 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272632001076 ATP binding site [chemical binding]; other site 272632001077 putative Mg++ binding site [ion binding]; other site 272632001078 Uncharacterized protein family (UPF0154); Region: UPF0154; cl01536 272632001079 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 272632001080 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 272632001081 TPP-binding site [chemical binding]; other site 272632001082 dimer interface [polypeptide binding]; other site 272632001083 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272632001084 PYR/PP interface [polypeptide binding]; other site 272632001085 dimer interface [polypeptide binding]; other site 272632001086 TPP binding site [chemical binding]; other site 272632001087 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272632001088 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 272632001089 Glucose inhibited division protein A; Region: GIDA; pfam01134 272632001090 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 272632001091 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 272632001092 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272632001093 ScpA/B protein; Region: ScpA_ScpB; cl00598 272632001094 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 272632001095 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 272632001096 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272632001097 RNA binding surface [nucleotide binding]; other site 272632001098 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 272632001099 active site 272632001100 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 272632001101 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 272632001102 Substrate-binding site [chemical binding]; other site 272632001103 Substrate specificity [chemical binding]; other site 272632001104 mycoides cluster lipoprotein, LppA/P72 family; Region: Mycoplas_LppA; TIGR03490 272632001105 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 272632001106 active site 272632001107 phosphorylation site [posttranslational modification] 272632001108 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 272632001109 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 272632001110 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 272632001111 active site 272632001112 P-loop; other site 272632001113 phosphorylation site [posttranslational modification] 272632001114 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 272632001115 substrate binding site [chemical binding]; other site 272632001116 hexamer interface [polypeptide binding]; other site 272632001117 metal binding site [ion binding]; metal-binding site 272632001118 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272632001119 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272632001120 Walker A/P-loop; other site 272632001121 ATP binding site [chemical binding]; other site 272632001122 Q-loop/lid; other site 272632001123 ABC transporter signature motif; other site 272632001124 Walker B; other site 272632001125 D-loop; other site 272632001126 H-loop/switch region; other site 272632001127 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 272632001128 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 272632001129 dimer interface [polypeptide binding]; other site 272632001130 substrate binding site [chemical binding]; other site 272632001131 metal binding sites [ion binding]; metal-binding site 272632001132 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 272632001133 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283 272632001134 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 272632001135 CMP-binding site; other site 272632001136 The sites determining sugar specificity; other site 272632001137 GTP-binding protein Der; Reviewed; Region: PRK00093 272632001138 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 272632001139 G1 box; other site 272632001140 GTP/Mg2+ binding site [chemical binding]; other site 272632001141 Switch I region; other site 272632001142 G2 box; other site 272632001143 Switch II region; other site 272632001144 G3 box; other site 272632001145 G4 box; other site 272632001146 G5 box; other site 272632001147 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 272632001148 G1 box; other site 272632001149 GTP/Mg2+ binding site [chemical binding]; other site 272632001150 Switch I region; other site 272632001151 G2 box; other site 272632001152 G3 box; other site 272632001153 Switch II region; other site 272632001154 G4 box; other site 272632001155 G5 box; other site 272632001156 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 272632001157 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 272632001158 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 272632001159 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 272632001160 histone-like DNA-binding protein HU; Region: HU; cd13831 272632001161 dimer interface [polypeptide binding]; other site 272632001162 DNA binding site [nucleotide binding] 272632001163 Recombination protein U; Region: RecU; cl01314 272632001164 cell division protein GpsB; Provisional; Region: PRK14127; cl19517 272632001165 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 272632001166 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 272632001167 Competence-damaged protein; Region: CinA; pfam02464 272632001168 recombinase A; Provisional; Region: recA; PRK09354 272632001169 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 272632001170 hexamer interface [polypeptide binding]; other site 272632001171 Walker A motif; other site 272632001172 ATP binding site [chemical binding]; other site 272632001173 Walker B motif; other site 272632001174 phosphodiesterase; Provisional; Region: PRK12704 272632001175 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272632001176 Zn2+ binding site [ion binding]; other site 272632001177 Mg2+ binding site [ion binding]; other site 272632001178 signal recognition particle protein; Region: ffh; TIGR00959 272632001179 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 272632001180 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 272632001181 Signal peptide binding domain; Region: SRP_SPB; pfam02978 272632001182 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 272632001183 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 272632001184 RimM protein, required for 16S rRNA processing [Translation, ribosomal structure and biogenesis]; Region: RimM; COG0806 272632001185 RimM N-terminal domain; Region: RimM; pfam01782 272632001186 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 272632001187 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 272632001188 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 272632001189 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 272632001190 GTP/Mg2+ binding site [chemical binding]; other site 272632001191 G4 box; other site 272632001192 G5 box; other site 272632001193 G1 box; other site 272632001194 Switch I region; other site 272632001195 G2 box; other site 272632001196 G3 box; other site 272632001197 Switch II region; other site 272632001198 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 272632001199 RNA/DNA hybrid binding site [nucleotide binding]; other site 272632001200 active site 272632001201 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 272632001202 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 272632001203 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 272632001204 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272632001205 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272632001206 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272632001207 Walker A/P-loop; other site 272632001208 ATP binding site [chemical binding]; other site 272632001209 Q-loop/lid; other site 272632001210 ABC transporter signature motif; other site 272632001211 Walker B; other site 272632001212 D-loop; other site 272632001213 H-loop/switch region; other site 272632001214 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272632001215 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272632001216 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 272632001217 Walker A/P-loop; other site 272632001218 ATP binding site [chemical binding]; other site 272632001219 Q-loop/lid; other site 272632001220 ABC transporter signature motif; other site 272632001221 Walker B; other site 272632001222 D-loop; other site 272632001223 H-loop/switch region; other site 272632001224 Protein of unknown function (DUF3196); Region: DUF3196; pfam11428 272632001225 GTPase CgtA; Reviewed; Region: obgE; PRK12297 272632001226 GTP1/OBG; Region: GTP1_OBG; pfam01018 272632001227 Obg GTPase; Region: Obg; cd01898 272632001228 G1 box; other site 272632001229 GTP/Mg2+ binding site [chemical binding]; other site 272632001230 Switch I region; other site 272632001231 G2 box; other site 272632001232 G3 box; other site 272632001233 Switch II region; other site 272632001234 G4 box; other site 272632001235 G5 box; other site 272632001236 Obg family GTPase CgtA, C-terminal extension; Region: Obg_CgtA_exten; TIGR03595 272632001237 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 272632001238 homodimer interface [polypeptide binding]; other site 272632001239 NAD binding pocket [chemical binding]; other site 272632001240 ATP binding pocket [chemical binding]; other site 272632001241 Mg binding site [ion binding]; other site 272632001242 active-site loop [active] 272632001243 putative nicotinate-nucleotide adenylyltransferase; Validated; Region: nadD; PRK07152 272632001244 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 272632001245 active site 272632001246 (T/H)XGH motif; other site 272632001247 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272632001248 Zn2+ binding site [ion binding]; other site 272632001249 Mg2+ binding site [ion binding]; other site 272632001250 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 272632001251 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 272632001252 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 272632001253 Substrate-binding site [chemical binding]; other site 272632001254 Substrate specificity [chemical binding]; other site 272632001255 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 272632001256 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 272632001257 Ligand Binding Site [chemical binding]; other site 272632001258 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 272632001259 Domain of unknown function(DUF2779); Region: DUF2779; pfam11074 272632001260 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 272632001261 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 272632001262 putative active site [active] 272632001263 substrate binding site [chemical binding]; other site 272632001264 putative cosubstrate binding site; other site 272632001265 catalytic site [active] 272632001266 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 272632001267 substrate binding site [chemical binding]; other site 272632001268 translation elongation factor P; Region: efp; TIGR00038 272632001269 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 272632001270 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 272632001271 RNA binding site [nucleotide binding]; other site 272632001272 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 272632001273 RNA binding site [nucleotide binding]; other site 272632001274 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 272632001275 trigger factor; Region: tig; TIGR00115 272632001276 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 272632001277 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 272632001278 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 272632001279 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 272632001280 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272632001281 Walker A motif; other site 272632001282 ATP binding site [chemical binding]; other site 272632001283 Walker B motif; other site 272632001284 arginine finger; other site 272632001285 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 272632001286 recombination factor protein RarA; Reviewed; Region: PRK13342 272632001287 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272632001288 Walker A motif; other site 272632001289 ATP binding site [chemical binding]; other site 272632001290 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl18944 272632001291 Walker B motif; other site 272632001292 arginine finger; other site 272632001293 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 272632001294 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 272632001295 FtsX-like permease family; Region: FtsX; pfam02687 272632001296 FtsX-like permease family; Region: FtsX; pfam02687 272632001297 DJ-1 family protein; Region: not_thiJ; TIGR01383 272632001298 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 272632001299 conserved cys residue [active] 272632001300 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39E; cd02424 272632001301 putative active site [active] 272632001302 probable rRNA maturation factor YbeY; Region: TIGR00043 272632001303 GTPase Era; Reviewed; Region: era; PRK00089 272632001304 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 272632001305 G1 box; other site 272632001306 GTP/Mg2+ binding site [chemical binding]; other site 272632001307 Switch I region; other site 272632001308 G2 box; other site 272632001309 Switch II region; other site 272632001310 G3 box; other site 272632001311 G4 box; other site 272632001312 G5 box; other site 272632001313 KH domain; Region: KH_2; pfam07650 272632001314 Recombination protein O N terminal; Region: RecO_N; pfam11967 272632001315 DNA repair protein RecO; Region: reco; TIGR00613 272632001316 Recombination protein O C terminal; Region: RecO_C; pfam02565 272632001317 glycyl-tRNA synthetase; Provisional; Region: PRK04173 272632001318 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 272632001319 dimer interface [polypeptide binding]; other site 272632001320 motif 1; other site 272632001321 active site 272632001322 motif 2; other site 272632001323 motif 3; other site 272632001324 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 272632001325 anticodon binding site; other site 272632001326 DNA primase; Validated; Region: dnaG; PRK05667 272632001327 CHC2 zinc finger; Region: zf-CHC2; cl17510 272632001328 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 272632001329 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 272632001330 active site 272632001331 metal binding site [ion binding]; metal-binding site 272632001332 interdomain interaction site; other site 272632001333 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 272632001334 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272632001335 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 272632001336 DNA binding residues [nucleotide binding] 272632001337 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 272632001338 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 272632001339 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 272632001340 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 272632001341 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 272632001342 ATP binding site [chemical binding]; other site 272632001343 putative Mg++ binding site [ion binding]; other site 272632001344 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272632001345 nucleotide binding region [chemical binding]; other site 272632001346 ATP-binding site [chemical binding]; other site 272632001347 Uncharacterized conserved protein [Function unknown]; Region: COG1284 272632001348 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272632001349 MMPL family; Region: MMPL; cl14618 272632001350 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272632001351 active site 272632001352 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 272632001353 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272632001354 Zn2+ binding site [ion binding]; other site 272632001355 Mg2+ binding site [ion binding]; other site 272632001356 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 272632001357 synthetase active site [active] 272632001358 NTP binding site [chemical binding]; other site 272632001359 metal binding site [ion binding]; metal-binding site 272632001360 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 272632001361 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 272632001362 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 272632001363 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 272632001364 Walker A/P-loop; other site 272632001365 ATP binding site [chemical binding]; other site 272632001366 Q-loop/lid; other site 272632001367 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 272632001368 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 272632001369 ABC transporter signature motif; other site 272632001370 Walker B; other site 272632001371 D-loop; other site 272632001372 H-loop/switch region; other site 272632001373 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 272632001374 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 272632001375 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 272632001376 dimerization interface [polypeptide binding]; other site 272632001377 active site 272632001378 metal binding site [ion binding]; metal-binding site 272632001379 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 272632001380 dsRNA binding site [nucleotide binding]; other site 272632001381 putative phosphate acyltransferase; Provisional; Region: PRK05331 272632001382 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 272632001383 DAK2 domain; Region: Dak2; pfam02734 272632001384 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 272632001385 Asp23 family; Region: Asp23; pfam03780 272632001386 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 272632001387 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 272632001388 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 272632001389 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272632001390 dimer interface [polypeptide binding]; other site 272632001391 conserved gate region; other site 272632001392 putative PBP binding loops; other site 272632001393 ABC-ATPase subunit interface; other site 272632001394 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 272632001395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272632001396 dimer interface [polypeptide binding]; other site 272632001397 conserved gate region; other site 272632001398 putative PBP binding loops; other site 272632001399 ABC-ATPase subunit interface; other site 272632001400 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 272632001401 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 272632001402 Walker A/P-loop; other site 272632001403 ATP binding site [chemical binding]; other site 272632001404 Q-loop/lid; other site 272632001405 ABC transporter signature motif; other site 272632001406 Walker B; other site 272632001407 D-loop; other site 272632001408 H-loop/switch region; other site 272632001409 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 272632001410 PhoU domain; Region: PhoU; pfam01895 272632001411 PhoU domain; Region: PhoU; pfam01895 272632001412 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 272632001413 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 272632001414 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 272632001415 P loop; other site 272632001416 GTP binding site [chemical binding]; other site 272632001417 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 272632001418 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 272632001419 putative active site [active] 272632001420 metal binding site [ion binding]; metal-binding site 272632001421 homodimer binding site [polypeptide binding]; other site 272632001422 S-adenosylmethionine synthetase; Validated; Region: PRK05250 272632001423 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 272632001424 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 272632001425 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 272632001426 CutC family; Region: CutC; cl01218 272632001427 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 272632001428 Glucose inhibited division protein A; Region: GIDA; pfam01134 272632001429 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 272632001430 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl19057 272632001431 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 272632001432 ligand binding site [chemical binding]; other site 272632001433 active site 272632001434 UGI interface [polypeptide binding]; other site 272632001435 catalytic site [active] 272632001436 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 272632001437 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 272632001438 generic binding surface II; other site 272632001439 generic binding surface I; other site 272632001440 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272632001441 Zn2+ binding site [ion binding]; other site 272632001442 Mg2+ binding site [ion binding]; other site 272632001443 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 272632001444 HIT family signature motif; other site 272632001445 catalytic residue [active] 272632001446 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 272632001447 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272632001448 catalytic residue [active] 272632001449 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 272632001450 trimerization site [polypeptide binding]; other site 272632001451 active site 272632001452 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 272632001453 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 272632001454 active site 272632001455 Zn binding site [ion binding]; other site 272632001456 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 272632001457 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 272632001458 active site 272632001459 dimer interface [polypeptide binding]; other site 272632001460 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 272632001461 dimer interface [polypeptide binding]; other site 272632001462 active site 272632001463 dUTPase; Region: dUTPase_2; pfam08761 272632001464 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 272632001465 active site 272632001466 homodimer interface [polypeptide binding]; other site 272632001467 metal binding site [ion binding]; metal-binding site 272632001468 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 272632001469 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 272632001470 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 272632001471 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 272632001472 tetrameric interface [polypeptide binding]; other site 272632001473 activator binding site; other site 272632001474 NADP binding site [chemical binding]; other site 272632001475 substrate binding site [chemical binding]; other site 272632001476 catalytic residues [active] 272632001477 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 272632001478 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272632001479 ATP binding site [chemical binding]; other site 272632001480 Mg2+ binding site [ion binding]; other site 272632001481 G-X-G motif; other site 272632001482 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 272632001483 anchoring element; other site 272632001484 dimer interface [polypeptide binding]; other site 272632001485 ATP binding site [chemical binding]; other site 272632001486 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 272632001487 active site 272632001488 metal binding site [ion binding]; metal-binding site 272632001489 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 272632001490 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 272632001491 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 272632001492 CAP-like domain; other site 272632001493 active site 272632001494 primary dimer interface [polypeptide binding]; other site 272632001495 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272632001496 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272632001497 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 272632001498 AAA domain; Region: AAA_30; pfam13604 272632001499 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 272632001500 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 272632001501 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272632001502 Walker A/P-loop; other site 272632001503 ATP binding site [chemical binding]; other site 272632001504 Q-loop/lid; other site 272632001505 ABC transporter signature motif; other site 272632001506 Walker B; other site 272632001507 D-loop; other site 272632001508 H-loop/switch region; other site 272632001509 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 272632001510 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 272632001511 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272632001512 Putative mycoplasma lipoprotein, C-terminal region; Region: Lipoprotein_10; pfam03202 272632001513 Transposase [DNA replication, recombination, and repair]; Region: COG5421 272632001514 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 272632001515 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 272632001516 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 272632001517 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 272632001518 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 272632001519 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 272632001520 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 272632001521 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 272632001522 Small proline-rich 2; Region: SPRR2; pfam14820 272632001523 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 272632001524 putative active site [active] 272632001525 putative FMN binding site [chemical binding]; other site 272632001526 putative substrate binding site [chemical binding]; other site 272632001527 putative catalytic residue [active] 272632001528 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 272632001529 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 272632001530 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 272632001531 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 272632001532 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 272632001533 lipoyl attachment site [posttranslational modification]; other site 272632001534 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272632001535 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 272632001536 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272632001537 Putative serine esterase (DUF676); Region: DUF676; pfam05057 272632001538 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 272632001539 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272632001540 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 272632001541 NAD binding site [chemical binding]; other site 272632001542 dimer interface [polypeptide binding]; other site 272632001543 substrate binding site [chemical binding]; other site 272632001544 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 272632001545 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 272632001546 active site 272632001547 dimer interface [polypeptide binding]; other site 272632001548 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272632001549 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 272632001550 Protein of unknown function (DUF342); Region: DUF342; cl19219 272632001551 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 272632001552 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 272632001553 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 272632001554 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 272632001555 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272632001556 Walker A motif; other site 272632001557 ATP binding site [chemical binding]; other site 272632001558 Walker B motif; other site 272632001559 arginine finger; other site 272632001560 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 272632001561 dihydrolipoamide dehydrogenase; Validated; Region: PRK06292 272632001562 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272632001563 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272632001564 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 272632001565 ribosome biogenesis GTPase YqeH; Region: GTPase_YqeH; TIGR03597 272632001566 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 272632001567 GTP/Mg2+ binding site [chemical binding]; other site 272632001568 G4 box; other site 272632001569 G5 box; other site 272632001570 G1 box; other site 272632001571 Switch I region; other site 272632001572 G2 box; other site 272632001573 G3 box; other site 272632001574 Switch II region; other site 272632001575 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 272632001576 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 272632001577 active site 272632001578 DNA binding site [nucleotide binding] 272632001579 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619 272632001580 active site 272632001581 Transposase [DNA replication, recombination, and repair]; Region: COG5421 272632001582 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 272632001583 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 272632001584 ATP-binding site [chemical binding]; other site 272632001585 Sugar specificity; other site 272632001586 Pyrimidine base specificity; other site 272632001587 hypothetical protein; Provisional; Region: PRK07205 272632001588 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 272632001589 active site 272632001590 metal binding site [ion binding]; metal-binding site 272632001591 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 272632001592 putative active site cavity [active] 272632001593 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 272632001594 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272632001595 nucleotide binding site [chemical binding]; other site 272632001596 Domain of unknown function (DUF386); Region: DUF386; cl01047 272632001597 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 272632001598 Na binding site [ion binding]; other site 272632001599 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 272632001600 inhibitor site; inhibition site 272632001601 active site 272632001602 dimer interface [polypeptide binding]; other site 272632001603 catalytic residue [active] 272632001604 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 272632001605 hypothetical protein; Provisional; Region: PRK14553 272632001606 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 272632001607 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 272632001608 putative SAM binding site [chemical binding]; other site 272632001609 putative homodimer interface [polypeptide binding]; other site 272632001610 mycoides cluster lipoprotein, LppA/P72 family; Region: Mycoplas_LppA; TIGR03490 272632001611 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272632001612 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 272632001613 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 272632001614 putative acyl-acceptor binding pocket; other site 272632001615 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 272632001616 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 272632001617 catalytic motif [active] 272632001618 Zn binding site [ion binding]; other site 272632001619 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 272632001620 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272632001621 RNA binding surface [nucleotide binding]; other site 272632001622 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 272632001623 active site 272632001624 lipoprotein signal peptidase; Provisional; Region: PRK14766 272632001625 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 272632001626 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 272632001627 active site 272632001628 HIGH motif; other site 272632001629 KMSKS motif; other site 272632001630 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 272632001631 tRNA binding surface [nucleotide binding]; other site 272632001632 anticodon binding site; other site 272632001633 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272632001634 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272632001635 Protein of unknown function (DUF552); Region: DUF552; pfam04472 272632001636 cell division protein FtsZ; Validated; Region: PRK09330 272632001637 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 272632001638 nucleotide binding site [chemical binding]; other site 272632001639 SulA interaction site; other site 272632001640 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 272632001641 cell division protein MraZ; Reviewed; Region: PRK00326 272632001642 MraZ protein; Region: MraZ; pfam02381 272632001643 MraZ protein; Region: MraZ; pfam02381 272632001644 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 272632001645 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 272632001646 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 272632001647 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 272632001648 putative tRNA-binding site [nucleotide binding]; other site 272632001649 B3/4 domain; Region: B3_4; smart00873 272632001650 tRNA synthetase B5 domain; Region: B5; pfam03484 272632001651 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 272632001652 motif 1; other site 272632001653 dimer interface [polypeptide binding]; other site 272632001654 active site 272632001655 motif 2; other site 272632001656 motif 3; other site 272632001657 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 272632001658 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 272632001659 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 272632001660 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 272632001661 dimer interface [polypeptide binding]; other site 272632001662 motif 1; other site 272632001663 active site 272632001664 motif 2; other site 272632001665 motif 3; other site 272632001666 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 272632001667 FtsX-like permease family; Region: FtsX; pfam02687 272632001668 FtsX-like permease family; Region: FtsX; pfam02687 272632001669 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 272632001670 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 272632001671 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 272632001672 active site 272632001673 HIGH motif; other site 272632001674 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272632001675 KMSK motif region; other site 272632001676 tRNA binding surface [nucleotide binding]; other site 272632001677 DALR anticodon binding domain; Region: DALR_1; smart00836 272632001678 anticodon binding site; other site 272632001679 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 272632001680 hinge region; other site 272632001681 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 272632001682 substrate binding site [chemical binding]; other site 272632001683 nucleotide binding site [chemical binding]; other site 272632001684 Transposase [DNA replication, recombination, and repair]; Region: COG5421 272632001685 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 272632001686 Transposase [DNA replication, recombination, and repair]; Region: COG5421 272632001687 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 272632001688 elongation factor Ts; Provisional; Region: tsf; PRK09377 272632001689 UBA/TS-N domain; Region: UBA; pfam00627 272632001690 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 272632001691 rRNA interaction site [nucleotide binding]; other site 272632001692 chaperone protein DnaJ; Provisional; Region: PRK14296 272632001693 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272632001694 HSP70 interaction site [polypeptide binding]; other site 272632001695 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 272632001696 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 272632001697 dimer interface [polypeptide binding]; other site 272632001698 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 272632001699 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 272632001700 nucleotide binding site [chemical binding]; other site 272632001701 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 272632001702 dimer interface [polypeptide binding]; other site 272632001703 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 272632001704 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 272632001705 heat shock gene repressor HrcA; Region: hrcA; TIGR00331 272632001706 HrcA protein C terminal domain; Region: HrcA; pfam01628 272632001707 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272632001708 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 272632001709 Walker A motif; other site 272632001710 ATP binding site [chemical binding]; other site 272632001711 Walker B motif; other site 272632001712 arginine finger; other site 272632001713 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272632001714 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 272632001715 Walker A motif; other site 272632001716 ATP binding site [chemical binding]; other site 272632001717 Walker B motif; other site 272632001718 arginine finger; other site 272632001719 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 272632001720 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 272632001721 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272632001722 active site 272632001723 motif I; other site 272632001724 motif II; other site 272632001725 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272632001726 motif II; other site 272632001727 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272632001728 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 272632001729 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 272632001730 active site 272632001731 dimerization interface [polypeptide binding]; other site 272632001732 reticulocyte binding/rhoptry protein; Region: 235kDa-fam; TIGR01612 272632001733 F0F1 ATP synthase subunit beta; Provisional; Region: PRK12597 272632001734 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272632001735 Walker A motif; other site 272632001736 ATP binding site [chemical binding]; other site 272632001737 Walker B motif; other site 272632001738 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 272632001739 F0F1 ATP synthase subunit alpha; Validated; Region: PRK07165 272632001740 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272632001741 Walker A motif; other site 272632001742 ATP binding site [chemical binding]; other site 272632001743 Walker B motif; other site 272632001744 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cl00365 272632001745 epsilon subunit interface [polypeptide binding]; other site 272632001746 Protein of unknown function (DUF2714); Region: DUF2714; pfam10896 272632001747 Putative peptidase (DUF31); Region: DUF31; pfam01732 272632001748 Mycoplasma virulence signal region (Myco_arth_vir_N); Region: Myco_arth_vir_N; pfam09610 272632001749 Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; cl19511 272632001750 Putative peptidase (DUF31); Region: DUF31; pfam01732 272632001751 Mycoplasma virulence signal region (Myco_arth_vir_N); Region: Myco_arth_vir_N; pfam09610 272632001752 putative transposase OrfB; Reviewed; Region: PHA02517 272632001753 HTH-like domain; Region: HTH_21; pfam13276 272632001754 Integrase core domain; Region: rve; pfam00665 272632001755 Integrase core domain; Region: rve_2; pfam13333 272632001756 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272632001757 Helix-turn-helix domain; Region: HTH_28; pfam13518 272632001758 Helix-turn-helix domain; Region: HTH_28; pfam13518 272632001759 Putative peptidase (DUF31); Region: DUF31; pfam01732 272632001760 Mycoplasma virulence signal region (Myco_arth_vir_N); Region: Myco_arth_vir_N; pfam09610 272632001761 Putative peptidase (DUF31); Region: DUF31; pfam01732 272632001762 Mycoplasma virulence signal region (Myco_arth_vir_N); Region: Myco_arth_vir_N; pfam09610 272632001763 Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088 272632001764 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272632001765 Walker A/P-loop; other site 272632001766 ATP binding site [chemical binding]; other site 272632001767 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 272632001768 intersubunit interface [polypeptide binding]; other site 272632001769 active site 272632001770 zinc binding site [ion binding]; other site 272632001771 Na+ binding site [ion binding]; other site 272632001772 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272632001773 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 272632001774 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272632001775 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 272632001776 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 272632001777 active site turn [active] 272632001778 phosphorylation site [posttranslational modification] 272632001779 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272632001780 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 272632001781 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 272632001782 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 272632001783 AAA domain; Region: AAA_30; pfam13604 272632001784 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 272632001785 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 272632001786 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 272632001787 bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167 272632001788 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 272632001789 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 272632001790 Part of AAA domain; Region: AAA_19; pfam13245 272632001791 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 272632001792 AAA domain; Region: AAA_12; pfam13087 272632001793 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 272632001794 putative active site [active] 272632001795 Fic family protein [Function unknown]; Region: COG3177 272632001796 Fic/DOC family; Region: Fic; pfam02661 272632001797 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 272632001798 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272632001799 Helix-turn-helix domain; Region: HTH_28; pfam13518 272632001800 Helix-turn-helix domain; Region: HTH_28; pfam13518 272632001801 putative transposase OrfB; Reviewed; Region: PHA02517 272632001802 HTH-like domain; Region: HTH_21; pfam13276 272632001803 Integrase core domain; Region: rve; pfam00665 272632001804 Integrase core domain; Region: rve_2; pfam13333 272632001805 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 272632001806 Fic/DOC family; Region: Fic; cl00960 272632001807 e3 binding domain; Region: E3_binding; pfam02817 272632001808 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 272632001809 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 272632001810 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 272632001811 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 272632001812 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272632001813 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 272632001814 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272632001815 Helix-turn-helix domain; Region: HTH_28; pfam13518 272632001816 Helix-turn-helix domain; Region: HTH_28; pfam13518 272632001817 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 272632001818 substrate binding site [chemical binding]; other site 272632001819 hinge regions; other site 272632001820 ADP binding site [chemical binding]; other site 272632001821 catalytic site [active] 272632001822 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 272632001823 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 272632001824 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 272632001825 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272632001826 Walker A motif; other site 272632001827 ATP binding site [chemical binding]; other site 272632001828 Walker B motif; other site 272632001829 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 272632001830 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 272632001831 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 272632001832 DNA binding site [nucleotide binding] 272632001833 catalytic residue [active] 272632001834 H2TH interface [polypeptide binding]; other site 272632001835 putative catalytic residues [active] 272632001836 turnover-facilitating residue; other site 272632001837 intercalation triad [nucleotide binding]; other site 272632001838 8OG recognition residue [nucleotide binding]; other site 272632001839 putative reading head residues; other site 272632001840 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 272632001841 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 272632001842 DNA polymerase I; Provisional; Region: PRK05755 272632001843 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 272632001844 active site 272632001845 metal binding site 1 [ion binding]; metal-binding site 272632001846 putative 5' ssDNA interaction site; other site 272632001847 metal binding site 3; metal-binding site 272632001848 metal binding site 2 [ion binding]; metal-binding site 272632001849 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 272632001850 putative DNA binding site [nucleotide binding]; other site 272632001851 putative metal binding site [ion binding]; other site 272632001852 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 272632001853 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 272632001854 active site 272632001855 DNA binding site [nucleotide binding] 272632001856 catalytic site [active] 272632001857 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 272632001858 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 272632001859 active site 272632001860 PHP Thumb interface [polypeptide binding]; other site 272632001861 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 272632001862 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 272632001863 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 272632001864 generic binding surface II; other site 272632001865 generic binding surface I; other site 272632001866 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272632001867 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 272632001868 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 272632001869 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 272632001870 active site 272632001871 HIGH motif; other site 272632001872 dimer interface [polypeptide binding]; other site 272632001873 KMSKS motif; other site 272632001874 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272632001875 RNA binding surface [nucleotide binding]; other site 272632001876 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 272632001877 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571 272632001878 active site 272632001879 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 272632001880 putative tRNA-binding site [nucleotide binding]; other site 272632001881 EDD domain protein, DegV family; Region: DegV; TIGR00762 272632001882 Uncharacterized protein, DegV family COG1307; Region: DegV; cl19360 272632001883 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 272632001884 metal binding site 2 [ion binding]; metal-binding site 272632001885 putative DNA binding helix; other site 272632001886 metal binding site 1 [ion binding]; metal-binding site 272632001887 dimer interface [polypeptide binding]; other site 272632001888 structural Zn2+ binding site [ion binding]; other site 272632001889 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 272632001890 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 272632001891 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 272632001892 active site 272632001893 Zn binding site [ion binding]; other site 272632001894 Transposase [DNA replication, recombination, and repair]; Region: COG5421 272632001895 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 272632001896 Integrase core domain; Region: rve; pfam00665 272632001897 Integrase core domain; Region: rve_3; cl15866 272632001898 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 272632001899 putative substrate binding site [chemical binding]; other site 272632001900 nucleotide binding site [chemical binding]; other site 272632001901 nucleotide binding site [chemical binding]; other site 272632001902 homodimer interface [polypeptide binding]; other site 272632001903 agmatine deiminase; Region: agmatine_aguA; TIGR03380 272632001904 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 272632001905 Amino acid permease; Region: AA_permease_2; pfam13520 272632001906 putrescine carbamoyltransferase; Provisional; Region: PRK02255 272632001907 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 272632001908 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 272632001909 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272632001910 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272632001911 Walker A/P-loop; other site 272632001912 ATP binding site [chemical binding]; other site 272632001913 Q-loop/lid; other site 272632001914 ABC transporter signature motif; other site 272632001915 Walker B; other site 272632001916 D-loop; other site 272632001917 H-loop/switch region; other site 272632001918 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 272632001919 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 272632001920 active site 272632001921 HIGH motif; other site 272632001922 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 272632001923 KMSKS motif; other site 272632001924 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 272632001925 tRNA binding surface [nucleotide binding]; other site 272632001926 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 272632001927 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 272632001928 23S rRNA interface [nucleotide binding]; other site 272632001929 L3 interface [polypeptide binding]; other site 272632001930 FtsX-like permease family; Region: FtsX; pfam02687 272632001931 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 272632001932 FtsX-like permease family; Region: FtsX; pfam02687 272632001933 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 272632001934 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 272632001935 dimerization interface 3.5A [polypeptide binding]; other site 272632001936 active site 272632001937 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 272632001938 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13645 272632001939 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 272632001940 Walker A/P-loop; other site 272632001941 ATP binding site [chemical binding]; other site 272632001942 Q-loop/lid; other site 272632001943 ABC transporter signature motif; other site 272632001944 Walker B; other site 272632001945 D-loop; other site 272632001946 H-loop/switch region; other site 272632001947 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 272632001948 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13632 272632001949 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 272632001950 Walker A/P-loop; other site 272632001951 ATP binding site [chemical binding]; other site 272632001952 Q-loop/lid; other site 272632001953 ABC transporter signature motif; other site 272632001954 Walker B; other site 272632001955 D-loop; other site 272632001956 H-loop/switch region; other site 272632001957 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 272632001958 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 272632001959 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 272632001960 alphaNTD homodimer interface [polypeptide binding]; other site 272632001961 alphaNTD - beta interaction site [polypeptide binding]; other site 272632001962 alphaNTD - beta' interaction site [polypeptide binding]; other site 272632001963 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 272632001964 30S ribosomal protein S11; Validated; Region: PRK05309 272632001965 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 272632001966 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 272632001967 rRNA binding site [nucleotide binding]; other site 272632001968 predicted 30S ribosome binding site; other site 272632001969 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 272632001970 active site 272632001971 adenylate kinase; Region: adk; TIGR01351 272632001972 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 272632001973 AMP-binding site [chemical binding]; other site 272632001974 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 272632001975 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 272632001976 SecY translocase; Region: SecY; pfam00344 272632001977 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 272632001978 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 272632001979 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 272632001980 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 272632001981 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 272632001982 5S rRNA interface [nucleotide binding]; other site 272632001983 L27 interface [polypeptide binding]; other site 272632001984 23S rRNA interface [nucleotide binding]; other site 272632001985 L5 interface [polypeptide binding]; other site 272632001986 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 272632001987 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 272632001988 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 272632001989 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 272632001990 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 272632001991 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 272632001992 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 272632001993 RNA binding site [nucleotide binding]; other site 272632001994 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 272632001995 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 272632001996 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 272632001997 putative translocon interaction site; other site 272632001998 23S rRNA interface [nucleotide binding]; other site 272632001999 signal recognition particle (SRP54) interaction site; other site 272632002000 L23 interface [polypeptide binding]; other site 272632002001 trigger factor interaction site; other site 272632002002 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 272632002003 23S rRNA interface [nucleotide binding]; other site 272632002004 5S rRNA interface [nucleotide binding]; other site 272632002005 putative antibiotic binding site [chemical binding]; other site 272632002006 L25 interface [polypeptide binding]; other site 272632002007 L27 interface [polypeptide binding]; other site 272632002008 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 272632002009 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 272632002010 G-X-X-G motif; other site 272632002011 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 272632002012 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 272632002013 putative translocon binding site; other site 272632002014 protein-rRNA interface [nucleotide binding]; other site 272632002015 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 272632002016 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 272632002017 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 272632002018 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 272632002019 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 272632002020 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 272632002021 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 272632002022 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 272632002023 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 272632002024 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 272632002025 active site 272632002026 catalytic site [active] 272632002027 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 272632002028 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272632002029 active site turn [active] 272632002030 phosphorylation site [posttranslational modification] 272632002031 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272632002032 Transcriptional regulators [Transcription]; Region: PurR; COG1609 272632002033 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 272632002034 DNA binding site [nucleotide binding] 272632002035 domain linker motif; other site 272632002036 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 272632002037 Tetraspanin family; Region: Tetraspannin; pfam00335 272632002038 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 272632002039 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 272632002040 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 272632002041 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 272632002042 homodimer interface [polypeptide binding]; other site 272632002043 NADP binding site [chemical binding]; other site 272632002044 substrate binding site [chemical binding]; other site 272632002045 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 272632002046 Cation transport protein; Region: TrkH; cl17365 272632002047 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 272632002048 TrkA-N domain; Region: TrkA_N; pfam02254 272632002049 TrkA-C domain; Region: TrkA_C; pfam02080 272632002050 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 272632002051 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 272632002052 GatB domain; Region: GatB_Yqey; pfam02637 272632002053 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 272632002054 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; pfam02686 272632002055 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 272632002056 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 272632002057 nucleotide binding pocket [chemical binding]; other site 272632002058 K-X-D-G motif; other site 272632002059 catalytic site [active] 272632002060 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 272632002061 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 272632002062 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 272632002063 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 272632002064 Dimer interface [polypeptide binding]; other site 272632002065 BRCT sequence motif; other site 272632002066 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 272632002067 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272632002068 RNA binding surface [nucleotide binding]; other site 272632002069 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 272632002070 active site 272632002071 CAAX protease self-immunity; Region: Abi; pfam02517 272632002072 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 272632002073 dimerization domain swap beta strand [polypeptide binding]; other site 272632002074 regulatory protein interface [polypeptide binding]; other site 272632002075 active site 272632002076 regulatory phosphorylation site [posttranslational modification]; other site 272632002077 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 272632002078 Part of AAA domain; Region: AAA_19; pfam13245 272632002079 AAA domain; Region: AAA_14; pfam13173 272632002080 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 272632002081 RDD family; Region: RDD; pfam06271 272632002082 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272632002083 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272632002084 active site 272632002085 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 272632002086 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 272632002087 SelR domain; Region: SelR; pfam01641 272632002088 hypothetical protein; Provisional; Region: PRK06148 272632002089 Protein of unknown function DUF262; Region: DUF262; pfam03235 272632002090 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272632002091 chromosome segregation protein; Provisional; Region: PRK03918 272632002092 hypothetical protein; Provisional; Region: PRK06148 272632002093 Transposase [DNA replication, recombination, and repair]; Region: COG5421 272632002094 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 272632002095 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272632002096 dimer interface [polypeptide binding]; other site 272632002097 conserved gate region; other site 272632002098 putative PBP binding loops; other site 272632002099 ABC-ATPase subunit interface; other site 272632002100 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 272632002101 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 272632002102 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272632002103 Walker A/P-loop; other site 272632002104 ATP binding site [chemical binding]; other site 272632002105 Q-loop/lid; other site 272632002106 ABC transporter signature motif; other site 272632002107 Walker B; other site 272632002108 D-loop; other site 272632002109 H-loop/switch region; other site 272632002110 High affinity transport system protein p37; Region: Mycoplasma_p37; pfam06646 272632002111 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 272632002112 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272632002113 active site 272632002114 motif I; other site 272632002115 motif II; other site 272632002116 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272632002117 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 272632002118 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272632002119 homodimer interface [polypeptide binding]; other site 272632002120 catalytic residue [active] 272632002121 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 272632002122 homotrimer interaction site [polypeptide binding]; other site 272632002123 putative active site [active] 272632002124 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272632002125 Transposase [DNA replication, recombination, and repair]; Region: COG5421 272632002126 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 272632002127 phosphodiesterase; Provisional; Region: PRK12704 272632002128 hypothetical protein; Provisional; Region: PRK06148 272632002129 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 272632002130 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272632002131 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 272632002132 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 272632002133 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272632002134 Walker A/P-loop; other site 272632002135 ATP binding site [chemical binding]; other site 272632002136 Q-loop/lid; other site 272632002137 ABC transporter signature motif; other site 272632002138 Walker B; other site 272632002139 D-loop; other site 272632002140 H-loop/switch region; other site 272632002141 High affinity transport system protein p37; Region: Mycoplasma_p37; pfam06646 272632002142 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 272632002143 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272632002144 active site 272632002145 motif I; other site 272632002146 motif II; other site 272632002147 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272632002148 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 272632002149 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 272632002150 pyridoxal 5'-phosphate binding site [chemical binding]; other site 272632002151 homodimer interface [polypeptide binding]; other site 272632002152 catalytic residue [active] 272632002153 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 272632002154 homotrimer interaction site [polypeptide binding]; other site 272632002155 putative active site [active] 272632002156 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272632002157 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 272632002158 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 272632002159 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 272632002160 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 272632002161 Transposase [DNA replication, recombination, and repair]; Region: COG5421 272632002162 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 272632002163 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 272632002164 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 272632002165 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 272632002166 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 272632002167 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 272632002168 active site 272632002169 trimer interface [polypeptide binding]; other site 272632002170 allosteric site; other site 272632002171 active site lid [active] 272632002172 hexamer (dimer of trimers) interface [polypeptide binding]; other site 272632002173 Transposase [DNA replication, recombination, and repair]; Region: COG5421 272632002174 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 272632002175 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 272632002176 substrate binding site [chemical binding]; other site 272632002177 dimer interface [polypeptide binding]; other site 272632002178 catalytic triad [active] 272632002179 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 272632002180 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272632002181 active site 272632002182 motif I; other site 272632002183 motif II; other site 272632002184 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272632002185 phosphoglyceromutase; Provisional; Region: PRK05434 272632002186 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 272632002187 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 272632002188 intersubunit interface [polypeptide binding]; other site 272632002189 catalytic residue [active] 272632002190 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 272632002191 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 272632002192 active site 272632002193 substrate binding site [chemical binding]; other site 272632002194 metal binding site [ion binding]; metal-binding site 272632002195 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 272632002196 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 272632002197 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 272632002198 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 272632002199 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 272632002200 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272632002201 active site 272632002202 phosphorylation site [posttranslational modification] 272632002203 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 272632002204 active site 272632002205 P-loop; other site 272632002206 phosphorylation site [posttranslational modification] 272632002207 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 272632002208 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 272632002209 putative substrate binding site [chemical binding]; other site 272632002210 putative ATP binding site [chemical binding]; other site 272632002211 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272632002212 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 272632002213 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272632002214 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 272632002215 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 272632002216 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272632002217 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 272632002218 Fic/DOC family; Region: Fic; cl00960 272632002219 Bacterial protein of unknown function (DUF871); Region: DUF871; cl19843 272632002220 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 272632002221 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 272632002222 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 272632002223 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272632002224 nucleotide binding site [chemical binding]; other site 272632002225 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 272632002226 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272632002227 active site 272632002228 phosphorylation site [posttranslational modification] 272632002229 putative transposase OrfB; Reviewed; Region: PHA02517 272632002230 HTH-like domain; Region: HTH_21; pfam13276 272632002231 Integrase core domain; Region: rve; pfam00665 272632002232 Integrase core domain; Region: rve_2; pfam13333 272632002233 alpha-mannosidase; Provisional; Region: PRK09819 272632002234 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 272632002235 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 272632002236 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 272632002237 active site 272632002238 P-loop; other site 272632002239 phosphorylation site [posttranslational modification] 272632002240 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 272632002241 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 272632002242 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272632002243 active site 272632002244 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 272632002245 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 272632002246 tetramer interface [polypeptide binding]; other site 272632002247 active site 272632002248 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 272632002249 GDP-binding site [chemical binding]; other site 272632002250 ACT binding site; other site 272632002251 IMP binding site; other site 272632002252 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272632002253 Helix-turn-helix domain; Region: HTH_28; pfam13518 272632002254 Helix-turn-helix domain; Region: HTH_28; pfam13518 272632002255 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07187 272632002256 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 272632002257 Class I ribonucleotide reductase; Region: RNR_I; cd01679 272632002258 active site 272632002259 dimer interface [polypeptide binding]; other site 272632002260 catalytic residues [active] 272632002261 effector binding site; other site 272632002262 R2 peptide binding site; other site 272632002263 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 272632002264 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 272632002265 dimer interface [polypeptide binding]; other site 272632002266 putative radical transfer pathway; other site 272632002267 diiron center [ion binding]; other site 272632002268 tyrosyl radical; other site 272632002269 ribonuclease R; Region: RNase_R; TIGR02063 272632002270 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 272632002271 RNB domain; Region: RNB; pfam00773 272632002272 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 272632002273 RNA binding site [nucleotide binding]; other site 272632002274 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 272632002275 SmpB-tmRNA interface; other site 272632002276 Transposase [DNA replication, recombination, and repair]; Region: COG5421 272632002277 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 272632002278 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 272632002279 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272632002280 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272632002281 active site turn [active] 272632002282 phosphorylation site [posttranslational modification] 272632002283 Beta-lactamase; Region: Beta-lactamase; pfam00144 272632002284 Transposase [DNA replication, recombination, and repair]; Region: COG5421 272632002285 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 272632002286 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 272632002287 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272632002288 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 272632002289 putative substrate binding site [chemical binding]; other site 272632002290 nucleotide binding site [chemical binding]; other site 272632002291 nucleotide binding site [chemical binding]; other site 272632002292 homodimer interface [polypeptide binding]; other site 272632002293 Predicted membrane protein [Function unknown]; Region: COG1288; cl17886 272632002294 Predicted membrane protein [Function unknown]; Region: COG1288; cl17886 272632002295 Predicted membrane protein [Function unknown]; Region: COG1288; cl17886 272632002296 magnesium-transporting ATPase; Provisional; Region: PRK15122 272632002297 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 272632002298 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272632002299 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 272632002300 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 272632002301 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 272632002302 Transposase [DNA replication, recombination, and repair]; Region: COG5421 272632002303 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 272632002304 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 272632002305 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272632002306 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272632002307 active site turn [active] 272632002308 phosphorylation site [posttranslational modification] 272632002309 Beta-lactamase; Region: Beta-lactamase; pfam00144 272632002310 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 272632002311 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 272632002312 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 272632002313 Transposase [DNA replication, recombination, and repair]; Region: COG5421 272632002314 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 272632002315 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 272632002316 putative substrate binding site [chemical binding]; other site 272632002317 nucleotide binding site [chemical binding]; other site 272632002318 nucleotide binding site [chemical binding]; other site 272632002319 homodimer interface [polypeptide binding]; other site 272632002320 Predicted membrane protein [Function unknown]; Region: COG1288; cl17886 272632002321 Predicted membrane protein [Function unknown]; Region: COG1288; cl17886 272632002322 Predicted membrane protein [Function unknown]; Region: COG1288; cl17886 272632002323 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 272632002324 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272632002325 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 272632002326 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 272632002327 gamma subunit interface [polypeptide binding]; other site 272632002328 epsilon subunit interface [polypeptide binding]; other site 272632002329 LBP interface [polypeptide binding]; other site 272632002330 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 272632002331 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 272632002332 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 272632002333 alpha subunit interaction interface [polypeptide binding]; other site 272632002334 Walker A motif; other site 272632002335 ATP binding site [chemical binding]; other site 272632002336 Walker B motif; other site 272632002337 inhibitor binding site; inhibition site 272632002338 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 272632002339 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 272632002340 core domain interface [polypeptide binding]; other site 272632002341 delta subunit interface [polypeptide binding]; other site 272632002342 epsilon subunit interface [polypeptide binding]; other site 272632002343 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 272632002344 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 272632002345 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 272632002346 beta subunit interaction interface [polypeptide binding]; other site 272632002347 Walker A motif; other site 272632002348 ATP binding site [chemical binding]; other site 272632002349 Walker B motif; other site 272632002350 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 272632002351 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13436 272632002352 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 272632002353 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 272632002354 ATP synthase subunit C; Region: ATP-synt_C; cl00466 272632002355 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 272632002356 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272632002357 active site 272632002358 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 272632002359 dimer interface [polypeptide binding]; other site 272632002360 active site 272632002361 glycine-pyridoxal phosphate binding site [chemical binding]; other site 272632002362 folate binding site [chemical binding]; other site 272632002363 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 272632002364 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 272632002365 active site residue [active] 272632002366 Putative peptidase (DUF31); Region: DUF31; pfam01732 272632002367 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272632002368 Helix-turn-helix domain; Region: HTH_28; pfam13518 272632002369 Helix-turn-helix domain; Region: HTH_28; pfam13518 272632002370 putative transposase OrfB; Reviewed; Region: PHA02517 272632002371 HTH-like domain; Region: HTH_21; pfam13276 272632002372 Integrase core domain; Region: rve; pfam00665 272632002373 Integrase core domain; Region: rve_2; pfam13333 272632002374 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 272632002375 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 272632002376 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 272632002377 active site 272632002378 putative oxyanion hole; other site 272632002379 catalytic triad [active] 272632002380 Mycoplasma MFS transporter; Region: MFS_Mycoplasma; pfam07672 272632002381 putative transposase OrfB; Reviewed; Region: PHA02517 272632002382 HTH-like domain; Region: HTH_21; pfam13276 272632002383 Integrase core domain; Region: rve; pfam00665 272632002384 Integrase core domain; Region: rve_2; pfam13333 272632002385 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 272632002386 Helix-turn-helix domain; Region: HTH_28; pfam13518 272632002387 Helix-turn-helix domain; Region: HTH_28; pfam13518 272632002388 Mitochondria Localisation Sequence; Region: AIF-MLS; pfam14962 272632002389 DNA sequence specific (IHF) and non-specific (HU) domains; Region: HU_IHF; cl00257 272632002390 dimer interface [polypeptide binding]; other site 272632002391 magnesium-translocating P-type ATPase; Region: ATPase-IIIB_Mg; TIGR01524 272632002392 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 272632002393 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272632002394 Soluble P-type ATPase [General function prediction only]; Region: COG4087 272632002395 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 272632002396 Amino acid permease; Region: AA_permease_2; pfam13520 272632002397 Amino acid permease; Region: AA_permease_2; pfam13520 272632002398 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 272632002399 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272632002400 S-adenosylmethionine binding site [chemical binding]; other site 272632002401 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 272632002402 GTP-binding protein YchF; Reviewed; Region: PRK09601 272632002403 YchF GTPase; Region: YchF; cd01900 272632002404 G1 box; other site 272632002405 GTP/Mg2+ binding site [chemical binding]; other site 272632002406 Switch I region; other site 272632002407 G2 box; other site 272632002408 Switch II region; other site 272632002409 G3 box; other site 272632002410 G4 box; other site 272632002411 G5 box; other site 272632002412 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 272632002413 Protein of unknown function DUF45; Region: DUF45; pfam01863 272632002414 Predicted membrane protein [Function unknown]; Region: COG1288 272632002415 Predicted membrane protein [Function unknown]; Region: COG1288; cl17886 272632002416 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 272632002417 Transposase [DNA replication, recombination, and repair]; Region: COG5421 272632002418 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 272632002419 aromatic cluster surface protein; Region: aro_clust_Mycop; TIGR04313 272632002420 aromatic cluster surface protein; Region: aro_clust_Mycop; TIGR04313 272632002421 aromatic cluster surface protein; Region: aro_clust_Mycop; TIGR04313 272632002422 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272632002423 Walker A/P-loop; other site 272632002424 ATP binding site [chemical binding]; other site 272632002425 DNA topoisomerase I; Validated; Region: PRK05582 272632002426 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 272632002427 active site 272632002428 interdomain interaction site; other site 272632002429 putative metal-binding site [ion binding]; other site 272632002430 nucleotide binding site [chemical binding]; other site 272632002431 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 272632002432 domain I; other site 272632002433 DNA binding groove [nucleotide binding] 272632002434 phosphate binding site [ion binding]; other site 272632002435 domain II; other site 272632002436 domain III; other site 272632002437 nucleotide binding site [chemical binding]; other site 272632002438 catalytic site [active] 272632002439 domain IV; other site 272632002440 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 272632002441 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272632002442 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272632002443 putative active site [active] 272632002444 Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088 272632002445 Transposase [DNA replication, recombination, and repair]; Region: COG5421 272632002446 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 272632002447 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 272632002448 WhiA N-terminal LAGLIDADG-like domain; Region: WhiA_N; pfam10298 272632002449 LAGLIDADG-like domain; Region: LAGLIDADG_3; cl08299 272632002450 WhiA C-terminal HTH domain; Region: HTH_WhiA; pfam02650 272632002451 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 272632002452 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 272632002453 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272632002454 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272632002455 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 272632002456 HPr kinase/phosphorylase; Provisional; Region: PRK05428 272632002457 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 272632002458 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 272632002459 Hpr binding site; other site 272632002460 active site 272632002461 homohexamer subunit interaction site [polypeptide binding]; other site 272632002462 Protein of unknown function (DUF3816); Region: DUF3816; cl17272 272632002463 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 272632002464 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 272632002465 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 272632002466 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 272632002467 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 272632002468 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 272632002469 excinuclease ABC subunit B; Provisional; Region: PRK05298 272632002470 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272632002471 ATP binding site [chemical binding]; other site 272632002472 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272632002473 nucleotide binding region [chemical binding]; other site 272632002474 ATP-binding site [chemical binding]; other site 272632002475 Ultra-violet resistance protein B; Region: UvrB; pfam12344 272632002476 UvrB/uvrC motif; Region: UVR; pfam02151 272632002477 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; cl19912 272632002478 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 272632002479 active site 272632002480 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 272632002481 cofactor binding site; other site 272632002482 DNA binding site [nucleotide binding] 272632002483 substrate interaction site [chemical binding]; other site 272632002484 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 272632002485 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 272632002486 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 272632002487 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 272632002488 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272632002489 active site 272632002490 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 272632002491 putative active site [active] 272632002492 catalytic residue [active] 272632002493 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 272632002494 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 272632002495 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 272632002496 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 272632002497 replicative DNA helicase; Region: DnaB; TIGR00665 272632002498 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 272632002499 Walker A motif; other site 272632002500 ATP binding site [chemical binding]; other site 272632002501 Walker B motif; other site 272632002502 DNA binding loops [nucleotide binding] 272632002503 hypothetical protein; Provisional; Region: PRK09609 272632002504 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 272632002505 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 272632002506 active site 272632002507 HIGH motif; other site 272632002508 KMSKS motif; other site 272632002509 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 272632002510 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 272632002511 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 272632002512 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 272632002513 preprotein translocase, SecE subunit, bacterial; Region: secE_bact; TIGR00964 272632002514 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 272632002515 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 272632002516 putative homodimer interface [polypeptide binding]; other site 272632002517 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 272632002518 heterodimer interface [polypeptide binding]; other site 272632002519 homodimer interface [polypeptide binding]; other site 272632002520 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 272632002521 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 272632002522 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272632002523 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272632002524 dimer interface [polypeptide binding]; other site 272632002525 conserved gate region; other site 272632002526 putative PBP binding loops; other site 272632002527 ABC-ATPase subunit interface; other site 272632002528 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 272632002529 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272632002530 dimer interface [polypeptide binding]; other site 272632002531 conserved gate region; other site 272632002532 putative PBP binding loops; other site 272632002533 ABC-ATPase subunit interface; other site 272632002534 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 272632002535 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272632002536 Walker A/P-loop; other site 272632002537 ATP binding site [chemical binding]; other site 272632002538 Q-loop/lid; other site 272632002539 ABC transporter signature motif; other site 272632002540 Walker B; other site 272632002541 D-loop; other site 272632002542 H-loop/switch region; other site 272632002543 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272632002544 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 272632002545 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272632002546 Walker A/P-loop; other site 272632002547 ATP binding site [chemical binding]; other site 272632002548 Q-loop/lid; other site 272632002549 ABC transporter signature motif; other site 272632002550 Walker B; other site 272632002551 D-loop; other site 272632002552 H-loop/switch region; other site 272632002553 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 272632002554 Transposase [DNA replication, recombination, and repair]; Region: COG5421 272632002555 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 272632002556 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272632002557 UDP-galactopyranose mutase; Region: GLF; pfam03275 272632002558 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 272632002559 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 272632002560 NAD binding site [chemical binding]; other site 272632002561 homodimer interface [polypeptide binding]; other site 272632002562 active site 272632002563 substrate binding site [chemical binding]; other site 272632002564 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 272632002565 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272632002566 DXD motif; other site 272632002567 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272632002568 ABC transporter signature motif; other site 272632002569 Walker B; other site 272632002570 D-loop; other site 272632002571 H-loop/switch region; other site 272632002572 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 272632002573 Transposase [DNA replication, recombination, and repair]; Region: COG5421 272632002574 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 272632002575 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272632002576 UDP-galactopyranose mutase; Region: GLF; pfam03275 272632002577 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 272632002578 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 272632002579 NAD binding site [chemical binding]; other site 272632002580 homodimer interface [polypeptide binding]; other site 272632002581 active site 272632002582 substrate binding site [chemical binding]; other site 272632002583 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 272632002584 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272632002585 DXD motif; other site 272632002586 Transposase [DNA replication, recombination, and repair]; Region: COG5421 272632002587 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 272632002588 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272632002589 ABC transporter signature motif; other site 272632002590 Walker B; other site 272632002591 D-loop; other site 272632002592 H-loop/switch region; other site 272632002593 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 272632002594 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 272632002595 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272632002596 UDP-galactopyranose mutase; Region: GLF; pfam03275 272632002597 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 272632002598 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272632002599 NAD(P) binding site [chemical binding]; other site 272632002600 active site 272632002601 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 272632002602 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272632002603 DXD motif; other site 272632002604 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272632002605 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272632002606 active site 272632002607 Transposase [DNA replication, recombination, and repair]; Region: COG5421 272632002608 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 272632002609 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 272632002610 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 272632002611 active site 272632002612 tetramer interface; other site 272632002613 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 272632002614 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 272632002615 DXD motif; other site 272632002616 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 272632002617 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 272632002618 23S rRNA interface [nucleotide binding]; other site 272632002619 L7/L12 interface [polypeptide binding]; other site 272632002620 putative thiostrepton binding site; other site 272632002621 L25 interface [polypeptide binding]; other site 272632002622 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 272632002623 mRNA/rRNA interface [nucleotide binding]; other site 272632002624 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 272632002625 Transposase [DNA replication, recombination, and repair]; Region: COG5421 272632002626 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 272632002627 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 272632002628 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 272632002629 23S rRNA interface [nucleotide binding]; other site 272632002630 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 272632002631 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 272632002632 core dimer interface [polypeptide binding]; other site 272632002633 peripheral dimer interface [polypeptide binding]; other site 272632002634 L10 interface [polypeptide binding]; other site 272632002635 L11 interface [polypeptide binding]; other site 272632002636 putative EF-Tu interaction site [polypeptide binding]; other site 272632002637 putative EF-G interaction site [polypeptide binding]; other site 272632002638 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 272632002639 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 272632002640 RPB12 interaction site [polypeptide binding]; other site 272632002641 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl19478 272632002642 RPB1 interaction site [polypeptide binding]; other site 272632002643 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 272632002644 RPB10 interaction site [polypeptide binding]; other site 272632002645 Peptidase family M23; Region: Peptidase_M23; pfam01551 272632002646 RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375 272632002647 RPB11 interaction site [polypeptide binding]; other site 272632002648 RPB3 interaction site [polypeptide binding]; other site 272632002649 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 272632002650 beta and beta' interface [polypeptide binding]; other site 272632002651 DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386 272632002652 beta' and sigma factor interface [polypeptide binding]; other site 272632002653 Zn-binding [ion binding]; other site 272632002654 active site region [active] 272632002655 catalytic site [active] 272632002656 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 272632002657 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 272632002658 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 272632002659 G-loop; other site 272632002660 DNA binding site [nucleotide binding] 272632002661 Transposase [DNA replication, recombination, and repair]; Region: COG5421 272632002662 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 272632002663 asparagine synthetase AsnA; Provisional; Region: PRK05425 272632002664 motif 1; other site 272632002665 dimer interface [polypeptide binding]; other site 272632002666 active site 272632002667 motif 2; other site 272632002668 motif 3; other site 272632002669 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 272632002670 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 272632002671 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 272632002672 Prion-inhibition and propagation; Region: HeLo; pfam14479 272632002673 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 272632002674 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 272632002675 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 272632002676 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272632002677 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272632002678 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 272632002679 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 272632002680 catalytic triad [active] 272632002681 conserved cis-peptide bond; other site 272632002682 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 272632002683 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 272632002684 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 272632002685 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 272632002686 phosphodiesterase; Provisional; Region: PRK12704 272632002687 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272632002688 Transposase [DNA replication, recombination, and repair]; Region: COG5421 272632002689 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 272632002690 asparagine synthetase AsnA; Provisional; Region: PRK05425 272632002691 motif 1; other site 272632002692 dimer interface [polypeptide binding]; other site 272632002693 active site 272632002694 motif 2; other site 272632002695 motif 3; other site 272632002696 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 272632002697 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 272632002698 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 272632002699 Prion-inhibition and propagation; Region: HeLo; pfam14479 272632002700 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 272632002701 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 272632002702 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 272632002703 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272632002704 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl19126 272632002705 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272632002706 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 272632002707 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 272632002708 catalytic triad [active] 272632002709 conserved cis-peptide bond; other site 272632002710 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 272632002711 Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382 272632002712 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 272632002713 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 272632002714 phosphodiesterase; Provisional; Region: PRK12704 272632002715 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 272632002716 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 272632002717 Subtilase family; Region: Peptidase_S8; pfam00082 272632002718 active site 272632002719 catalytic triad [active] 272632002720 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 272632002721 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272632002722 Walker A motif; other site 272632002723 ATP binding site [chemical binding]; other site 272632002724 Walker B motif; other site 272632002725 arginine finger; other site 272632002726 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 272632002727 active site 272632002728 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 272632002729 active site 272632002730 ATP binding site [chemical binding]; other site 272632002731 Phosphotransferase enzyme family; Region: APH; pfam01636 272632002732 substrate binding site [chemical binding]; other site 272632002733 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272632002734 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 272632002735 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02201 272632002736 Ribonuclease P; Region: Ribonuclease_P; pfam00825 272632002737 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399