-- dump date 20140619_161532 -- class Genbank::misc_feature -- table misc_feature_note -- id note 272633000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 272633000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272633000003 Walker A motif; other site 272633000004 ATP binding site [chemical binding]; other site 272633000005 Walker B motif; other site 272633000006 arginine finger; other site 272633000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 272633000008 DnaA box-binding interface [nucleotide binding]; other site 272633000009 DNA polymerase III subunit beta; Validated; Region: PRK05643 272633000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 272633000011 putative DNA binding surface [nucleotide binding]; other site 272633000012 dimer interface [polypeptide binding]; other site 272633000013 beta-clamp/clamp loader binding surface; other site 272633000014 beta-clamp/translesion DNA polymerase binding surface; other site 272633000015 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 272633000016 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272633000017 ATP binding site [chemical binding]; other site 272633000018 Mg2+ binding site [ion binding]; other site 272633000019 G-X-G motif; other site 272633000020 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 272633000021 anchoring element; other site 272633000022 dimer interface [polypeptide binding]; other site 272633000023 ATP binding site [chemical binding]; other site 272633000024 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 272633000025 active site 272633000026 putative metal-binding site [ion binding]; other site 272633000027 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 272633000028 DNA gyrase subunit A; Validated; Region: PRK05560 272633000029 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 272633000030 CAP-like domain; other site 272633000031 active site 272633000032 primary dimer interface [polypeptide binding]; other site 272633000033 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272633000034 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272633000035 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272633000036 Transposase, Mutator family; Region: Transposase_mut; pfam00872 272633000037 Transposase, Mutator family; Region: Transposase_mut; pfam00872 272633000038 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 272633000039 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272633000040 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272633000041 Magnesium ion binding site [ion binding]; other site 272633000042 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 272633000043 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 272633000044 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 272633000045 active site 272633000046 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 272633000047 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 272633000048 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 272633000049 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 272633000050 active site 272633000051 tetramer interface; other site 272633000052 Integrase core domain; Region: rve; pfam00665 272633000053 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 272633000054 BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463 272633000055 triosephosphate isomerase; Provisional; Region: PRK14567 272633000056 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 272633000057 substrate binding site [chemical binding]; other site 272633000058 dimer interface [polypeptide binding]; other site 272633000059 catalytic triad [active] 272633000060 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 272633000061 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272633000062 active site 272633000063 HIGH motif; other site 272633000064 nucleotide binding site [chemical binding]; other site 272633000065 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272633000066 active site 272633000067 KMSKS motif; other site 272633000068 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 272633000069 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 272633000070 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 272633000071 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 272633000072 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 272633000073 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 272633000074 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 272633000075 23S rRNA interface [nucleotide binding]; other site 272633000076 L7/L12 interface [polypeptide binding]; other site 272633000077 putative thiostrepton binding site; other site 272633000078 L25 interface [polypeptide binding]; other site 272633000079 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 272633000080 mRNA/rRNA interface [nucleotide binding]; other site 272633000081 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272633000082 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272633000083 active site 272633000084 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 272633000085 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 272633000086 S17 interaction site [polypeptide binding]; other site 272633000087 S8 interaction site; other site 272633000088 16S rRNA interaction site [nucleotide binding]; other site 272633000089 streptomycin interaction site [chemical binding]; other site 272633000090 23S rRNA interaction site [nucleotide binding]; other site 272633000091 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 272633000092 30S ribosomal protein S7; Validated; Region: PRK05302 272633000093 elongation factor G; Reviewed; Region: PRK00007 272633000094 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 272633000095 G1 box; other site 272633000096 putative GEF interaction site [polypeptide binding]; other site 272633000097 GTP/Mg2+ binding site [chemical binding]; other site 272633000098 Switch I region; other site 272633000099 G2 box; other site 272633000100 G3 box; other site 272633000101 Switch II region; other site 272633000102 G4 box; other site 272633000103 G5 box; other site 272633000104 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 272633000105 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 272633000106 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 272633000107 elongation factor Tu; Reviewed; Region: PRK00049 272633000108 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 272633000109 G1 box; other site 272633000110 GEF interaction site [polypeptide binding]; other site 272633000111 GTP/Mg2+ binding site [chemical binding]; other site 272633000112 Switch I region; other site 272633000113 G2 box; other site 272633000114 G3 box; other site 272633000115 Switch II region; other site 272633000116 G4 box; other site 272633000117 G5 box; other site 272633000118 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 272633000119 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 272633000120 Antibiotic Binding Site [chemical binding]; other site 272633000121 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 272633000122 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 272633000123 generic binding surface I; other site 272633000124 generic binding surface II; other site 272633000125 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 272633000126 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 272633000127 putative acyl-acceptor binding pocket; other site 272633000128 ScpA/B protein; Region: ScpA_ScpB; cl00598 272633000129 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 272633000130 hypothetical protein; Provisional; Region: PRK00523 272633000131 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 272633000132 G1 box; other site 272633000133 GTP/Mg2+ binding site [chemical binding]; other site 272633000134 Switch I region; other site 272633000135 G2 box; other site 272633000136 G3 box; other site 272633000137 Switch II region; other site 272633000138 G4 box; other site 272633000139 G5 box; other site 272633000140 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 272633000141 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272633000142 active site 272633000143 HIGH motif; other site 272633000144 nucleotide binding site [chemical binding]; other site 272633000145 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 272633000146 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 272633000147 active site 272633000148 KMSKS motif; other site 272633000149 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 272633000150 tRNA binding surface [nucleotide binding]; other site 272633000151 anticodon binding site; other site 272633000152 Competence protein; Region: Competence; pfam03772 272633000153 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 272633000154 hypothetical protein; Provisional; Region: PRK09609 272633000155 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 272633000156 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 272633000157 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 272633000158 putative active site [active] 272633000159 substrate binding site [chemical binding]; other site 272633000160 putative cosubstrate binding site; other site 272633000161 catalytic site [active] 272633000162 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 272633000163 substrate binding site [chemical binding]; other site 272633000164 GTP-binding protein LepA; Provisional; Region: PRK05433 272633000165 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 272633000166 G1 box; other site 272633000167 putative GEF interaction site [polypeptide binding]; other site 272633000168 GTP/Mg2+ binding site [chemical binding]; other site 272633000169 Switch I region; other site 272633000170 G2 box; other site 272633000171 G3 box; other site 272633000172 Switch II region; other site 272633000173 G4 box; other site 272633000174 G5 box; other site 272633000175 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 272633000176 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 272633000177 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 272633000178 CTP synthetase; Validated; Region: pyrG; PRK05380 272633000179 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 272633000180 Catalytic site [active] 272633000181 active site 272633000182 UTP binding site [chemical binding]; other site 272633000183 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 272633000184 active site 272633000185 putative oxyanion hole; other site 272633000186 catalytic triad [active] 272633000187 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 272633000188 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 272633000189 GTP/Mg2+ binding site [chemical binding]; other site 272633000190 G4 box; other site 272633000191 G1 box; other site 272633000192 Switch I region; other site 272633000193 G2 box; other site 272633000194 G3 box; other site 272633000195 Switch II region; other site 272633000196 DNA protecting protein DprA; Region: dprA; TIGR00732 272633000197 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 272633000198 ATP synthase subunit C; Region: ATP-synt_C; cl00466 272633000199 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 272633000200 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 272633000201 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 272633000202 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 272633000203 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 272633000204 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 272633000205 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 272633000206 beta subunit interaction interface [polypeptide binding]; other site 272633000207 Walker A motif; other site 272633000208 ATP binding site [chemical binding]; other site 272633000209 Walker B motif; other site 272633000210 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 272633000211 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 272633000212 core domain interface [polypeptide binding]; other site 272633000213 delta subunit interface [polypeptide binding]; other site 272633000214 epsilon subunit interface [polypeptide binding]; other site 272633000215 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 272633000216 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 272633000217 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 272633000218 alpha subunit interaction interface [polypeptide binding]; other site 272633000219 Walker A motif; other site 272633000220 ATP binding site [chemical binding]; other site 272633000221 Walker B motif; other site 272633000222 inhibitor binding site; inhibition site 272633000223 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 272633000224 F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) [Energy production and conversion]; Region: AtpC; COG0355 272633000225 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 272633000226 gamma subunit interface [polypeptide binding]; other site 272633000227 epsilon subunit interface [polypeptide binding]; other site 272633000228 LBP interface [polypeptide binding]; other site 272633000229 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 272633000230 peptide chain release factor 1; Validated; Region: prfA; PRK00591 272633000231 This domain is found in peptide chain release factors; Region: PCRF; smart00937 272633000232 RF-1 domain; Region: RF-1; pfam00472 272633000233 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 272633000234 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272633000235 S-adenosylmethionine binding site [chemical binding]; other site 272633000236 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 272633000237 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 272633000238 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 272633000239 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 272633000240 DNA binding site [nucleotide binding] 272633000241 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 272633000242 DJ-1 family protein; Region: not_thiJ; TIGR01383 272633000243 conserved cys residue [active] 272633000244 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 272633000245 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 272633000246 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 272633000247 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 272633000248 TPP-binding site; other site 272633000249 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272633000250 PYR/PP interface [polypeptide binding]; other site 272633000251 dimer interface [polypeptide binding]; other site 272633000252 TPP binding site [chemical binding]; other site 272633000253 Abi-like protein; Region: Abi_2; pfam07751 272633000254 NifU-like domain; Region: NifU; cl00484 272633000255 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 272633000256 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 272633000257 TPP-binding site [chemical binding]; other site 272633000258 dimer interface [polypeptide binding]; other site 272633000259 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272633000260 PYR/PP interface [polypeptide binding]; other site 272633000261 dimer interface [polypeptide binding]; other site 272633000262 TPP binding site [chemical binding]; other site 272633000263 pyruvate kinase; Provisional; Region: PRK05826 272633000264 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 272633000265 active site 272633000266 domain interfaces; other site 272633000267 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 272633000268 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 272633000269 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 272633000270 RPB1 interaction site [polypeptide binding]; other site 272633000271 RPB10 interaction site [polypeptide binding]; other site 272633000272 RPB11 interaction site [polypeptide binding]; other site 272633000273 RPB3 interaction site [polypeptide binding]; other site 272633000274 RPB12 interaction site [polypeptide binding]; other site 272633000275 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 272633000276 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 272633000277 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 272633000278 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 272633000279 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 272633000280 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 272633000281 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 272633000282 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 272633000283 G-loop; other site 272633000284 DNA binding site [nucleotide binding] 272633000285 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 272633000286 23S rRNA interface [nucleotide binding]; other site 272633000287 L3 interface [polypeptide binding]; other site 272633000288 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 272633000289 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272633000290 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 272633000291 active site 272633000292 motif I; other site 272633000293 motif II; other site 272633000294 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 272633000295 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07187 272633000296 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 272633000297 Class I ribonucleotide reductase; Region: RNR_I; cd01679 272633000298 active site 272633000299 dimer interface [polypeptide binding]; other site 272633000300 catalytic residues [active] 272633000301 effector binding site; other site 272633000302 R2 peptide binding site; other site 272633000303 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 272633000304 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 272633000305 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 272633000306 dimer interface [polypeptide binding]; other site 272633000307 putative radical transfer pathway; other site 272633000308 diiron center [ion binding]; other site 272633000309 tyrosyl radical; other site 272633000310 FtsX-like permease family; Region: FtsX; pfam02687 272633000311 FtsX-like permease family; Region: FtsX; pfam02687 272633000312 FtsX-like permease family; Region: FtsX; pfam02687 272633000313 FtsX-like permease family; Region: FtsX; pfam02687 272633000314 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 272633000315 S-adenosylmethionine synthetase; Validated; Region: PRK05250 272633000316 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 272633000317 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 272633000318 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 272633000319 M penetrans paralogue family 26; Region: MpPF26; pfam07666 272633000320 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272633000321 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272633000322 Walker A/P-loop; other site 272633000323 ATP binding site [chemical binding]; other site 272633000324 Q-loop/lid; other site 272633000325 ABC transporter signature motif; other site 272633000326 Walker B; other site 272633000327 D-loop; other site 272633000328 H-loop/switch region; other site 272633000329 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 272633000330 oligomerisation interface [polypeptide binding]; other site 272633000331 mobile loop; other site 272633000332 roof hairpin; other site 272633000333 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 272633000334 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 272633000335 ring oligomerisation interface [polypeptide binding]; other site 272633000336 ATP/Mg binding site [chemical binding]; other site 272633000337 stacking interactions; other site 272633000338 hinge regions; other site 272633000339 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 272633000340 trimer interface [polypeptide binding]; other site 272633000341 active site 272633000342 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 272633000343 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 272633000344 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 272633000345 Purine-nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: DeoD; COG0813 272633000346 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 272633000347 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 272633000348 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 272633000349 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 272633000350 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 272633000351 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 272633000352 active site 272633000353 catalytic motif [active] 272633000354 Zn binding site [ion binding]; other site 272633000355 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 272633000356 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 272633000357 active site 272633000358 substrate binding site [chemical binding]; other site 272633000359 metal binding site [ion binding]; metal-binding site 272633000360 transcription termination factor NusA; Region: NusA; TIGR01953 272633000361 NusA N-terminal domain; Region: NusA_N; pfam08529 272633000362 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 272633000363 RNA binding site [nucleotide binding]; other site 272633000364 homodimer interface [polypeptide binding]; other site 272633000365 NusA-like KH domain; Region: KH_5; pfam13184 272633000366 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 272633000367 G-X-X-G motif; other site 272633000368 translation initiation factor IF-2; Region: IF-2; TIGR00487 272633000369 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 272633000370 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 272633000371 G1 box; other site 272633000372 putative GEF interaction site [polypeptide binding]; other site 272633000373 GTP/Mg2+ binding site [chemical binding]; other site 272633000374 Switch I region; other site 272633000375 G2 box; other site 272633000376 G3 box; other site 272633000377 Switch II region; other site 272633000378 G4 box; other site 272633000379 G5 box; other site 272633000380 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 272633000381 Translation-initiation factor 2; Region: IF-2; pfam11987 272633000382 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 272633000383 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 272633000384 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 272633000385 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 272633000386 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 272633000387 dimer interface [polypeptide binding]; other site 272633000388 ssDNA binding site [nucleotide binding]; other site 272633000389 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272633000390 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 272633000391 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 272633000392 intersubunit interface [polypeptide binding]; other site 272633000393 active site 272633000394 catalytic residue [active] 272633000395 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 272633000396 DJ-1 family protein; Region: not_thiJ; TIGR01383 272633000397 conserved cys residue [active] 272633000398 endonuclease IV; Provisional; Region: PRK01060 272633000399 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 272633000400 AP (apurinic/apyrimidinic) site pocket; other site 272633000401 DNA interaction; other site 272633000402 Metal-binding active site; metal-binding site 272633000403 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 272633000404 metal binding site 2 [ion binding]; metal-binding site 272633000405 putative DNA binding helix; other site 272633000406 metal binding site 1 [ion binding]; metal-binding site 272633000407 dimer interface [polypeptide binding]; other site 272633000408 structural Zn2+ binding site [ion binding]; other site 272633000409 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 272633000410 GMP synthase; Reviewed; Region: guaA; PRK00074 272633000411 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 272633000412 AMP/PPi binding site [chemical binding]; other site 272633000413 candidate oxyanion hole; other site 272633000414 catalytic triad [active] 272633000415 potential glutamine specificity residues [chemical binding]; other site 272633000416 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 272633000417 ATP Binding subdomain [chemical binding]; other site 272633000418 Ligand Binding sites [chemical binding]; other site 272633000419 Dimerization subdomain; other site 272633000420 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 272633000421 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 272633000422 Helix-turn-helix domain; Region: HTH_38; pfam13936 272633000423 Integrase core domain; Region: rve; pfam00665 272633000424 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 272633000425 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 272633000426 GIY-YIG motif/motif A; other site 272633000427 active site 272633000428 catalytic site [active] 272633000429 putative DNA binding site [nucleotide binding]; other site 272633000430 metal binding site [ion binding]; metal-binding site 272633000431 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 272633000432 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 272633000433 active site 272633000434 catalytic site [active] 272633000435 substrate binding site [chemical binding]; other site 272633000436 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 272633000437 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 272633000438 active site 272633000439 metal binding site [ion binding]; metal-binding site 272633000440 homotetramer interface [polypeptide binding]; other site 272633000441 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 272633000442 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 272633000443 Coenzyme A binding pocket [chemical binding]; other site 272633000444 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 272633000445 Glycoprotease family; Region: Peptidase_M22; pfam00814 272633000446 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 272633000447 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272633000448 RNA binding surface [nucleotide binding]; other site 272633000449 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 272633000450 active site 272633000451 lipoprotein signal peptidase; Provisional; Region: PRK14780 272633000452 LytB protein; Region: LYTB; cl00507 272633000453 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 272633000454 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272633000455 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272633000456 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272633000457 active site turn [active] 272633000458 phosphorylation site [posttranslational modification] 272633000459 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 272633000460 HPr interaction site; other site 272633000461 glycerol kinase (GK) interaction site [polypeptide binding]; other site 272633000462 active site 272633000463 phosphorylation site [posttranslational modification] 272633000464 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 272633000465 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272633000466 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272633000467 Predicted methyltransferases [General function prediction only]; Region: COG0313 272633000468 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 272633000469 putative SAM binding site [chemical binding]; other site 272633000470 putative homodimer interface [polypeptide binding]; other site 272633000471 recombination factor protein RarA; Reviewed; Region: PRK13342 272633000472 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272633000473 Walker A motif; other site 272633000474 ATP binding site [chemical binding]; other site 272633000475 Walker B motif; other site 272633000476 arginine finger; other site 272633000477 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 272633000478 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 272633000479 putative active site [active] 272633000480 catalytic residue [active] 272633000481 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 272633000482 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 272633000483 Ligand Binding Site [chemical binding]; other site 272633000484 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 272633000485 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 272633000486 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 272633000487 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 272633000488 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 272633000489 dimer interface [polypeptide binding]; other site 272633000490 active site 272633000491 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 272633000492 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 272633000493 active site 272633000494 DNA binding site [nucleotide binding] 272633000495 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 272633000496 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272633000497 RNA binding surface [nucleotide binding]; other site 272633000498 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 272633000499 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 272633000500 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 272633000501 DNA polymerase III PolC; Validated; Region: polC; PRK00448 272633000502 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 272633000503 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 272633000504 V-type ATP synthase subunit I; Validated; Region: PRK05771 272633000505 translation elongation factor P; Region: efp; TIGR00038 272633000506 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 272633000507 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 272633000508 RNA binding site [nucleotide binding]; other site 272633000509 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 272633000510 RNA binding site [nucleotide binding]; other site 272633000511 transcription antitermination factor NusB; Region: nusB; TIGR01951 272633000512 RNA methyltransferase, RsmE family; Region: TIGR00046 272633000513 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 272633000514 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 272633000515 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 272633000516 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272633000517 FeS/SAM binding site; other site 272633000518 Uncharacterized conserved protein [Function unknown]; Region: COG4095 272633000519 Putative peptidase (DUF31); Region: DUF31; pfam01732 272633000520 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 272633000521 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272633000522 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 272633000523 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 272633000524 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 272633000525 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272633000526 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272633000527 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 272633000528 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 272633000529 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 272633000530 putative trimer interface [polypeptide binding]; other site 272633000531 putative CoA binding site [chemical binding]; other site 272633000532 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272633000533 catalytic residues [active] 272633000534 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 272633000535 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 272633000536 putative active site [active] 272633000537 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 272633000538 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl17885 272633000539 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272633000540 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272633000541 active site turn [active] 272633000542 phosphorylation site [posttranslational modification] 272633000543 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 272633000544 HPr interaction site; other site 272633000545 glycerol kinase (GK) interaction site [polypeptide binding]; other site 272633000546 active site 272633000547 phosphorylation site [posttranslational modification] 272633000548 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 272633000549 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 272633000550 putative active site cavity [active] 272633000551 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 272633000552 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 272633000553 active site 272633000554 dimer interface [polypeptide binding]; other site 272633000555 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 272633000556 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 272633000557 active site 272633000558 trimer interface [polypeptide binding]; other site 272633000559 allosteric site; other site 272633000560 active site lid [active] 272633000561 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 272633000562 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 272633000563 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 272633000564 AlwI restriction endonuclease; Region: RE_AlwI; pfam09491 272633000565 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 272633000566 NAD-dependent DNA ligase (contains BRCT domain type II) [DNA replication, recombination, and repair]; Region: Lig; COG0272 272633000567 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 272633000568 nucleotide binding pocket [chemical binding]; other site 272633000569 K-X-D-G motif; other site 272633000570 catalytic site [active] 272633000571 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 272633000572 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 272633000573 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 272633000574 Dimer interface [polypeptide binding]; other site 272633000575 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 272633000576 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 272633000577 DNA binding site [nucleotide binding] 272633000578 active site 272633000579 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 272633000580 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 272633000581 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 272633000582 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272633000583 Walker A/P-loop; other site 272633000584 ATP binding site [chemical binding]; other site 272633000585 Q-loop/lid; other site 272633000586 ABC transporter signature motif; other site 272633000587 Walker B; other site 272633000588 D-loop; other site 272633000589 H-loop/switch region; other site 272633000590 azoreductase; Reviewed; Region: PRK01355 272633000591 GTPase CgtA; Reviewed; Region: obgE; PRK12297 272633000592 GTP1/OBG; Region: GTP1_OBG; pfam01018 272633000593 Obg GTPase; Region: Obg; cd01898 272633000594 G1 box; other site 272633000595 GTP/Mg2+ binding site [chemical binding]; other site 272633000596 Switch I region; other site 272633000597 G2 box; other site 272633000598 G3 box; other site 272633000599 Switch II region; other site 272633000600 G4 box; other site 272633000601 G5 box; other site 272633000602 Obg family GTPase CgtA, C-terminal extension; Region: Obg_CgtA_exten; TIGR03595 272633000603 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 272633000604 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 272633000605 homodimer interface [polypeptide binding]; other site 272633000606 NAD binding pocket [chemical binding]; other site 272633000607 ATP binding pocket [chemical binding]; other site 272633000608 Mg binding site [ion binding]; other site 272633000609 active-site loop [active] 272633000610 DNA polymerase III DnaE; Validated; Region: dnaE; PRK05898 272633000611 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 272633000612 active site 272633000613 PHP Thumb interface [polypeptide binding]; other site 272633000614 5'-3' exonuclease; Provisional; Region: PRK14976 272633000615 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 272633000616 active site 272633000617 metal binding site 1 [ion binding]; metal-binding site 272633000618 putative 5' ssDNA interaction site; other site 272633000619 metal binding site 3; metal-binding site 272633000620 metal binding site 2 [ion binding]; metal-binding site 272633000621 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 272633000622 putative DNA binding site [nucleotide binding]; other site 272633000623 putative metal binding site [ion binding]; other site 272633000624 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 272633000625 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 272633000626 DNA binding site [nucleotide binding] 272633000627 catalytic residue [active] 272633000628 H2TH interface [polypeptide binding]; other site 272633000629 putative catalytic residues [active] 272633000630 turnover-facilitating residue; other site 272633000631 intercalation triad [nucleotide binding]; other site 272633000632 8OG recognition residue [nucleotide binding]; other site 272633000633 putative reading head residues; other site 272633000634 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 272633000635 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 272633000636 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 272633000637 CoA-binding site [chemical binding]; other site 272633000638 ATP-binding [chemical binding]; other site 272633000639 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 272633000640 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 272633000641 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 272633000642 replicative DNA helicase; Region: DnaB; TIGR00665 272633000643 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 272633000644 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 272633000645 Walker A motif; other site 272633000646 ATP binding site [chemical binding]; other site 272633000647 Walker B motif; other site 272633000648 DNA binding loops [nucleotide binding] 272633000649 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 272633000650 ligand binding site [chemical binding]; other site 272633000651 active site 272633000652 UGI interface [polypeptide binding]; other site 272633000653 catalytic site [active] 272633000654 hypothetical protein; Provisional; Region: PRK09609 272633000655 hypothetical protein; Provisional; Region: PRK09609 272633000656 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; pfam02686 272633000657 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 272633000658 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 272633000659 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 272633000660 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 272633000661 GatB domain; Region: GatB_Yqey; pfam02637 272633000662 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 272633000663 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 272633000664 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 272633000665 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272633000666 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 272633000667 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272633000668 motif II; other site 272633000669 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 272633000670 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 272633000671 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272633000672 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 272633000673 Walker A motif; other site 272633000674 ATP binding site [chemical binding]; other site 272633000675 Walker B motif; other site 272633000676 arginine finger; other site 272633000677 HTH domain; Region: HTH_11; cl17392 272633000678 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 272633000679 Integrase core domain; Region: rve; pfam00665 272633000680 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 272633000681 gating phenylalanine in ion channel; other site 272633000682 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 272633000683 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272633000684 Walker A/P-loop; other site 272633000685 ATP binding site [chemical binding]; other site 272633000686 Q-loop/lid; other site 272633000687 ABC transporter signature motif; other site 272633000688 Walker B; other site 272633000689 D-loop; other site 272633000690 H-loop/switch region; other site 272633000691 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 272633000692 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 272633000693 Walker A/P-loop; other site 272633000694 ATP binding site [chemical binding]; other site 272633000695 Q-loop/lid; other site 272633000696 ABC transporter signature motif; other site 272633000697 Walker B; other site 272633000698 D-loop; other site 272633000699 H-loop/switch region; other site 272633000700 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 272633000701 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 272633000702 active site 272633000703 ATP binding site [chemical binding]; other site 272633000704 substrate binding site [chemical binding]; other site 272633000705 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 272633000706 DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337 272633000707 AAA domain; Region: AAA_14; pfam13173 272633000708 AAA domain; Region: AAA_22; pfam13401 272633000709 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 272633000710 Cytidylate kinase [Nucleotide transport and metabolism]; Region: Cmk; COG0283 272633000711 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 272633000712 CMP-binding site; other site 272633000713 The sites determining sugar specificity; other site 272633000714 ribosome-associated GTPase EngA; Region: GTPase_EngA; TIGR03594 272633000715 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 272633000716 G1 box; other site 272633000717 GTP/Mg2+ binding site [chemical binding]; other site 272633000718 Switch I region; other site 272633000719 G2 box; other site 272633000720 Switch II region; other site 272633000721 G3 box; other site 272633000722 G4 box; other site 272633000723 G5 box; other site 272633000724 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 272633000725 G1 box; other site 272633000726 GTP/Mg2+ binding site [chemical binding]; other site 272633000727 Switch I region; other site 272633000728 G2 box; other site 272633000729 G3 box; other site 272633000730 Switch II region; other site 272633000731 G4 box; other site 272633000732 G5 box; other site 272633000733 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GpsA; COG0240 272633000734 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 272633000735 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 272633000736 Integrase core domain; Region: rve; pfam00665 272633000737 EDD domain protein, DegV family; Region: DegV; TIGR00762 272633000738 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 272633000739 Integrase core domain; Region: rve; pfam00665 272633000740 M penetrans paralogue family 26; Region: MpPF26; pfam07666 272633000741 M penetrans paralogue family 26; Region: MpPF26; pfam07666 272633000742 M penetrans paralogue family 26; Region: MpPF26; pfam07666 272633000743 M penetrans paralogue family 26; Region: MpPF26; pfam07666 272633000744 M penetrans paralogue family 26; Region: MpPF26; pfam07666 272633000745 M penetrans paralogue family 26; Region: MpPF26; pfam07666 272633000746 Recombination protein U; Region: RecU; pfam03838 272633000747 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272633000748 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272633000749 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272633000750 Walker A/P-loop; other site 272633000751 ATP binding site [chemical binding]; other site 272633000752 Q-loop/lid; other site 272633000753 ABC transporter signature motif; other site 272633000754 Walker B; other site 272633000755 D-loop; other site 272633000756 H-loop/switch region; other site 272633000757 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272633000758 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272633000759 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 272633000760 Walker A/P-loop; other site 272633000761 ATP binding site [chemical binding]; other site 272633000762 Q-loop/lid; other site 272633000763 ABC transporter signature motif; other site 272633000764 Walker B; other site 272633000765 D-loop; other site 272633000766 H-loop/switch region; other site 272633000767 Bacterial DNA-binding protein; Region: Bac_DNA_binding; pfam00216 272633000768 Putative peptidase (DUF31); Region: DUF31; pfam01732 272633000769 signal recognition particle protein; Provisional; Region: PRK10867 272633000770 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 272633000771 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 272633000772 P loop; other site 272633000773 GTP binding site [chemical binding]; other site 272633000774 Signal peptide binding domain; Region: SRP_SPB; pfam02978 272633000775 Peptidase family M50; Region: Peptidase_M50; pfam02163 272633000776 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 272633000777 active site 272633000778 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 272633000779 putative substrate binding region [chemical binding]; other site 272633000780 Lipoprotein associated domain; Region: Lipoprotein_17; pfam04200 272633000781 Lipoprotein associated domain; Region: Lipoprotein_17; pfam04200 272633000782 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 272633000783 Divergent AAA domain; Region: AAA_4; pfam04326 272633000784 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 272633000785 Lipoprotein associated domain; Region: Lipoprotein_17; pfam04200 272633000786 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272633000787 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272633000788 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272633000789 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272633000790 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633000791 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633000792 Membrane transport protein; Region: Mem_trans; cl09117 272633000793 (R)-2-Hydroxyglutarate Dehydrogenase and related dehydrogenases, NAD-binding and catalytic domains; Region: HGDH_like; cd12184 272633000794 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 272633000795 putative homodimer interface [polypeptide binding]; other site 272633000796 putative ligand binding site [chemical binding]; other site 272633000797 putative NAD binding site [chemical binding]; other site 272633000798 catalytic site [active] 272633000799 Lipoprotein associated domain; Region: Lipoprotein_17; pfam04200 272633000800 Lipoprotein associated domain; Region: Lipoprotein_17; pfam04200 272633000801 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633000802 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633000803 Lipoprotein associated domain; Region: Lipoprotein_17; pfam04200 272633000804 Lipoprotein associated domain; Region: Lipoprotein_17; pfam04200 272633000805 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 272633000806 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 272633000807 dimer interface [polypeptide binding]; other site 272633000808 active site 272633000809 glycine-pyridoxal phosphate binding site [chemical binding]; other site 272633000810 folate binding site [chemical binding]; other site 272633000811 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 272633000812 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 272633000813 active site 272633000814 dimer interface [polypeptide binding]; other site 272633000815 motif 1; other site 272633000816 motif 2; other site 272633000817 motif 3; other site 272633000818 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 272633000819 anticodon binding site; other site 272633000820 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 272633000821 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 272633000822 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 272633000823 substrate binding site; other site 272633000824 dimer interface; other site 272633000825 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 272633000826 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272633000827 Walker A motif; other site 272633000828 ATP binding site [chemical binding]; other site 272633000829 Walker B motif; other site 272633000830 arginine finger; other site 272633000831 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 272633000832 Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632 272633000833 RuvA N terminal domain; Region: RuvA_N; pfam01330 272633000834 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 272633000835 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 272633000836 dimerization domain swap beta strand [polypeptide binding]; other site 272633000837 regulatory protein interface [polypeptide binding]; other site 272633000838 active site 272633000839 regulatory phosphorylation site [posttranslational modification]; other site 272633000840 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 272633000841 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 272633000842 putative active site [active] 272633000843 catalytic site [active] 272633000844 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 272633000845 putative active site [active] 272633000846 catalytic site [active] 272633000847 oligoendopeptidase F; Region: pepF; TIGR00181 272633000848 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 272633000849 active site 272633000850 Zn binding site [ion binding]; other site 272633000851 histidyl-tRNA synthetase; Region: hisS; TIGR00442 272633000852 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 272633000853 dimer interface [polypeptide binding]; other site 272633000854 motif 1; other site 272633000855 active site 272633000856 motif 2; other site 272633000857 motif 3; other site 272633000858 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 272633000859 anticodon binding site; other site 272633000860 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 272633000861 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 272633000862 dimer interface [polypeptide binding]; other site 272633000863 anticodon binding site; other site 272633000864 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 272633000865 homodimer interface [polypeptide binding]; other site 272633000866 motif 1; other site 272633000867 active site 272633000868 motif 2; other site 272633000869 GAD domain; Region: GAD; pfam02938 272633000870 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 272633000871 motif 3; other site 272633000872 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 272633000873 Putative peptidase (DUF31); Region: DUF31; pfam01732 272633000874 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 272633000875 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 272633000876 active site 272633000877 catalytic residues [active] 272633000878 DNA binding site [nucleotide binding] 272633000879 Int/Topo IB signature motif; other site 272633000880 Domain of unknown function(DUF2779); Region: DUF2779; pfam11074 272633000881 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 272633000882 Ferritin-like domain; Region: Ferritin; pfam00210 272633000883 ferroxidase diiron center [ion binding]; other site 272633000884 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 272633000885 Predicted flavoprotein [General function prediction only]; Region: COG0431 272633000886 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 272633000887 MarR family; Region: MarR_2; cl17246 272633000888 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 272633000889 nudix motif; other site 272633000890 Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679 272633000891 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 272633000892 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 272633000893 Hpr binding site; other site 272633000894 active site 272633000895 homohexamer subunit interaction site [polypeptide binding]; other site 272633000896 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 272633000897 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 272633000898 TrkA-N domain; Region: TrkA_N; pfam02254 272633000899 TrkA-C domain; Region: TrkA_C; pfam02080 272633000900 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 272633000901 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 272633000902 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272633000903 Walker A/P-loop; other site 272633000904 ATP binding site [chemical binding]; other site 272633000905 Q-loop/lid; other site 272633000906 ABC transporter signature motif; other site 272633000907 Walker B; other site 272633000908 D-loop; other site 272633000909 H-loop/switch region; other site 272633000910 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 272633000911 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 272633000912 substrate binding site [chemical binding]; other site 272633000913 hexamer interface [polypeptide binding]; other site 272633000914 metal binding site [ion binding]; metal-binding site 272633000915 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 272633000916 Amidohydrolase family; Region: Amidohydro_3; pfam07969 272633000917 active site 272633000918 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 272633000919 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272633000920 Walker A/P-loop; other site 272633000921 ATP binding site [chemical binding]; other site 272633000922 Q-loop/lid; other site 272633000923 ABC transporter signature motif; other site 272633000924 Walker B; other site 272633000925 D-loop; other site 272633000926 H-loop/switch region; other site 272633000927 Putative peptidase (DUF31); Region: DUF31; pfam01732 272633000928 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 272633000929 NADH(P)-binding; Region: NAD_binding_10; pfam13460 272633000930 NAD binding site [chemical binding]; other site 272633000931 substrate binding site [chemical binding]; other site 272633000932 putative active site [active] 272633000933 Predicted transcriptional regulator [Transcription]; Region: COG1959 272633000934 Transcriptional regulator; Region: Rrf2; pfam02082 272633000935 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 272633000936 Phosphotransferase enzyme family; Region: APH; pfam01636 272633000937 active site 272633000938 ATP binding site [chemical binding]; other site 272633000939 substrate binding site [chemical binding]; other site 272633000940 dimer interface [polypeptide binding]; other site 272633000941 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 272633000942 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 272633000943 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 272633000944 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 272633000945 active site 272633000946 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 272633000947 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 272633000948 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 272633000949 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272633000950 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 272633000951 active site 272633000952 motif I; other site 272633000953 motif II; other site 272633000954 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 272633000955 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 272633000956 active site 272633000957 Peptidase M60-like family; Region: M60-like; pfam13402 272633000958 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 272633000959 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 272633000960 MraW methylase family; Region: Methyltransf_5; cl17771 272633000961 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 272633000962 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 272633000963 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272633000964 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 272633000965 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272633000966 motif II; other site 272633000967 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 272633000968 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272633000969 catalytic residues [active] 272633000970 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 272633000971 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 272633000972 ribonuclease R; Region: RNase_R; TIGR02063 272633000973 RNB domain; Region: RNB; pfam00773 272633000974 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 272633000975 RNA binding site [nucleotide binding]; other site 272633000976 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 272633000977 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 272633000978 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 272633000979 dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364 272633000980 probable rRNA maturation factor YbeY; Region: TIGR00043 272633000981 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 272633000982 GTPase Era; Reviewed; Region: era; PRK00089 272633000983 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 272633000984 Switch I region; other site 272633000985 GTP/Mg2+ binding site [chemical binding]; other site 272633000986 G2 box; other site 272633000987 Switch II region; other site 272633000988 G3 box; other site 272633000989 G4 box; other site 272633000990 G5 box; other site 272633000991 Recombination protein O N terminal; Region: RecO_N; pfam11967 272633000992 DNA repair protein RecO; Region: reco; TIGR00613 272633000993 Recombination protein O C terminal; Region: RecO_C; pfam02565 272633000994 glycyl-tRNA synthetase; Provisional; Region: PRK04173 272633000995 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 272633000996 motif 1; other site 272633000997 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 272633000998 active site 272633000999 motif 2; other site 272633001000 motif 3; other site 272633001001 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 272633001002 anticodon binding site; other site 272633001003 CHC2 zinc finger; Region: zf-CHC2; cl17510 272633001004 DNA primase (bacterial type) [DNA replication, recombination, and repair]; Region: DnaG; COG0358 272633001005 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 272633001006 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 272633001007 active site 272633001008 metal binding site [ion binding]; metal-binding site 272633001009 interdomain interaction site; other site 272633001010 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 272633001011 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 272633001012 Amino acid permease; Region: AA_permease_2; pfam13520 272633001013 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272633001014 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272633001015 Walker A/P-loop; other site 272633001016 ATP binding site [chemical binding]; other site 272633001017 Q-loop/lid; other site 272633001018 ABC transporter signature motif; other site 272633001019 Walker B; other site 272633001020 D-loop; other site 272633001021 H-loop/switch region; other site 272633001022 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 272633001023 HIT family signature motif; other site 272633001024 catalytic residue [active] 272633001025 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 272633001026 SmpB-tmRNA interface; other site 272633001027 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 272633001028 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 272633001029 metal binding site [ion binding]; metal-binding site 272633001030 dimer interface [polypeptide binding]; other site 272633001031 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 272633001032 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272633001033 Walker A/P-loop; other site 272633001034 ATP binding site [chemical binding]; other site 272633001035 Q-loop/lid; other site 272633001036 ABC transporter signature motif; other site 272633001037 Walker B; other site 272633001038 D-loop; other site 272633001039 H-loop/switch region; other site 272633001040 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 272633001041 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272633001042 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272633001043 ABC transporter; Region: ABC_tran_2; pfam12848 272633001044 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 272633001045 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272633001046 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272633001047 Walker A/P-loop; other site 272633001048 ATP binding site [chemical binding]; other site 272633001049 Q-loop/lid; other site 272633001050 ABC transporter signature motif; other site 272633001051 Walker B; other site 272633001052 D-loop; other site 272633001053 H-loop/switch region; other site 272633001054 putative phosphate acyltransferase; Provisional; Region: PRK05331 272633001055 ribonuclease III; Reviewed; Region: rnc; PRK00102 272633001056 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 272633001057 dimerization interface [polypeptide binding]; other site 272633001058 active site 272633001059 metal binding site [ion binding]; metal-binding site 272633001060 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 272633001061 dsRNA binding site [nucleotide binding]; other site 272633001062 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 272633001063 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 272633001064 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 272633001065 triosephosphate isomerase; Provisional; Region: PRK14565 272633001066 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 272633001067 substrate binding site [chemical binding]; other site 272633001068 dimer interface [polypeptide binding]; other site 272633001069 catalytic triad [active] 272633001070 phosphoglyceromutase; Provisional; Region: PRK05434 272633001071 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 272633001072 enolase; Provisional; Region: eno; PRK00077 272633001073 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 272633001074 dimer interface [polypeptide binding]; other site 272633001075 metal binding site [ion binding]; metal-binding site 272633001076 substrate binding pocket [chemical binding]; other site 272633001077 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 272633001078 catalytic triad [active] 272633001079 conserved cis-peptide bond; other site 272633001080 Protein of unknown function (DUF1600); Region: DUF1600; pfam07667 272633001081 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272633001082 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 272633001083 Walker A motif; other site 272633001084 ATP binding site [chemical binding]; other site 272633001085 Walker B motif; other site 272633001086 arginine finger; other site 272633001087 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 272633001088 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272633001089 Walker A motif; other site 272633001090 ATP binding site [chemical binding]; other site 272633001091 Walker B motif; other site 272633001092 arginine finger; other site 272633001093 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 272633001094 Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044 272633001095 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272633001096 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 272633001097 active site 272633001098 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 272633001099 16S/18S rRNA binding site [nucleotide binding]; other site 272633001100 S13e-L30e interaction site [polypeptide binding]; other site 272633001101 25S rRNA binding site [nucleotide binding]; other site 272633001102 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 272633001103 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 272633001104 HIGH motif; other site 272633001105 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 272633001106 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272633001107 active site 272633001108 KMSKS motif; other site 272633001109 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 272633001110 tRNA binding surface [nucleotide binding]; other site 272633001111 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 272633001112 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 272633001113 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 272633001114 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 272633001115 active site 272633001116 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 272633001117 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 272633001118 NAD(P) binding site [chemical binding]; other site 272633001119 catalytic residues [active] 272633001120 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272633001121 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 272633001122 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 272633001123 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272633001124 Walker A motif; other site 272633001125 ATP binding site [chemical binding]; other site 272633001126 Walker B motif; other site 272633001127 arginine finger; other site 272633001128 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 272633001129 metal ion-dependent adhesion site (MIDAS); other site 272633001130 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 272633001131 dimer interface [polypeptide binding]; other site 272633001132 catalytic triad [active] 272633001133 peroxidatic and resolving cysteines [active] 272633001134 Abi-like protein; Region: Abi_2; pfam07751 272633001135 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 272633001136 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 272633001137 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 272633001138 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 272633001139 putative dimer interface [polypeptide binding]; other site 272633001140 putative anticodon binding site; other site 272633001141 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 272633001142 homodimer interface [polypeptide binding]; other site 272633001143 motif 1; other site 272633001144 motif 2; other site 272633001145 active site 272633001146 motif 3; other site 272633001147 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 272633001148 seryl-tRNA synthetase; Provisional; Region: PRK05431 272633001149 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 272633001150 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 272633001151 dimer interface [polypeptide binding]; other site 272633001152 active site 272633001153 motif 1; other site 272633001154 motif 2; other site 272633001155 motif 3; other site 272633001156 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 272633001157 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272633001158 Walker A/P-loop; other site 272633001159 ATP binding site [chemical binding]; other site 272633001160 Q-loop/lid; other site 272633001161 ABC transporter signature motif; other site 272633001162 Walker B; other site 272633001163 H-loop/switch region; other site 272633001164 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272633001165 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272633001166 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272633001167 Walker A/P-loop; other site 272633001168 ATP binding site [chemical binding]; other site 272633001169 Q-loop/lid; other site 272633001170 ABC transporter signature motif; other site 272633001171 Walker B; other site 272633001172 D-loop; other site 272633001173 H-loop/switch region; other site 272633001174 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272633001175 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272633001176 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 272633001177 Walker A/P-loop; other site 272633001178 ATP binding site [chemical binding]; other site 272633001179 Q-loop/lid; other site 272633001180 ABC transporter signature motif; other site 272633001181 Walker B; other site 272633001182 D-loop; other site 272633001183 H-loop/switch region; other site 272633001184 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 272633001185 NAD(P) binding site [chemical binding]; other site 272633001186 catalytic residues [active] 272633001187 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 272633001188 DAK2 domain; Region: Dak2; pfam02734 272633001189 DNA topoisomerase I; Validated; Region: PRK05582 272633001190 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 272633001191 active site 272633001192 interdomain interaction site; other site 272633001193 putative metal-binding site [ion binding]; other site 272633001194 nucleotide binding site [chemical binding]; other site 272633001195 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 272633001196 domain I; other site 272633001197 DNA binding groove [nucleotide binding] 272633001198 phosphate binding site [ion binding]; other site 272633001199 domain II; other site 272633001200 domain III; other site 272633001201 nucleotide binding site [chemical binding]; other site 272633001202 catalytic site [active] 272633001203 domain IV; other site 272633001204 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 272633001205 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 272633001206 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 272633001207 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719 272633001208 GIY-YIG motif/motif A; other site 272633001209 active site 272633001210 catalytic site [active] 272633001211 metal binding site [ion binding]; metal-binding site 272633001212 HTH domain; Region: HTH_11; cl17392 272633001213 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 272633001214 Integrase core domain; Region: rve; pfam00665 272633001215 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272633001216 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 272633001217 Walker A motif; other site 272633001218 ATP binding site [chemical binding]; other site 272633001219 Walker B motif; other site 272633001220 arginine finger; other site 272633001221 AAA domain; Region: AAA_14; pfam13173 272633001222 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 272633001223 Archaeal ATPase; Region: Arch_ATPase; pfam01637 272633001224 AAA ATPase domain; Region: AAA_16; pfam13191 272633001225 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 272633001226 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 272633001227 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 272633001228 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 272633001229 Peptidase M60-like family; Region: M60-like; pfam13402 272633001230 Peptidase M60-like family; Region: M60-like; pfam13402 272633001231 ribonuclease E; Reviewed; Region: rne; PRK10811 272633001232 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 272633001233 putative catalytic site [active] 272633001234 putative phosphate binding site [ion binding]; other site 272633001235 putative metal binding site [ion binding]; other site 272633001236 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 272633001237 putative metal binding site [ion binding]; other site 272633001238 inorganic pyrophosphatase; Provisional; Region: PRK02230 272633001239 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 272633001240 dimer interface [polypeptide binding]; other site 272633001241 substrate binding site [chemical binding]; other site 272633001242 metal binding sites [ion binding]; metal-binding site 272633001243 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 272633001244 Protein of unknown function (DUF464); Region: DUF464; pfam04327 272633001245 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 272633001246 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 272633001247 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 272633001248 phosphate binding site [ion binding]; other site 272633001249 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 272633001250 PRD domain; Region: PRD; pfam00874 272633001251 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272633001252 active site 272633001253 phosphorylation site [posttranslational modification] 272633001254 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272633001255 active site 272633001256 phosphorylation site [posttranslational modification] 272633001257 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 272633001258 active site 272633001259 P-loop; other site 272633001260 phosphorylation site [posttranslational modification] 272633001261 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 272633001262 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 272633001263 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 272633001264 TPP-binding site [chemical binding]; other site 272633001265 dimer interface [polypeptide binding]; other site 272633001266 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272633001267 PYR/PP interface [polypeptide binding]; other site 272633001268 dimer interface [polypeptide binding]; other site 272633001269 TPP binding site [chemical binding]; other site 272633001270 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 272633001271 HPr interaction site; other site 272633001272 glycerol kinase (GK) interaction site [polypeptide binding]; other site 272633001273 active site 272633001274 phosphorylation site [posttranslational modification] 272633001275 PTS system, glucose-like IIB component; Region: EIIB_glc; TIGR00826 272633001276 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 272633001277 active site turn [active] 272633001278 phosphorylation site [posttranslational modification] 272633001279 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272633001280 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 272633001281 putative substrate translocation pore; other site 272633001282 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 272633001283 beta-galactosidase; Region: BGL; TIGR03356 272633001284 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 272633001285 beta-galactosidase; Region: BGL; TIGR03356 272633001286 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 272633001287 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 272633001288 active site 272633001289 motif I; other site 272633001290 motif II; other site 272633001291 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 272633001292 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 272633001293 active site 272633001294 HIGH motif; other site 272633001295 dimer interface [polypeptide binding]; other site 272633001296 KMSKS motif; other site 272633001297 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 272633001298 ArsC family; Region: ArsC; pfam03960 272633001299 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 272633001300 ATP-NAD kinase; Region: NAD_kinase; pfam01513 272633001301 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 272633001302 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 272633001303 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 272633001304 tetramer interface [polypeptide binding]; other site 272633001305 catalytic Zn binding site [ion binding]; other site 272633001306 NADP binding site [chemical binding]; other site 272633001307 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 272633001308 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 272633001309 active site 272633001310 dimer interface [polypeptide binding]; other site 272633001311 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 272633001312 dimer interface [polypeptide binding]; other site 272633001313 active site 272633001314 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 272633001315 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 272633001316 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 272633001317 tetrameric interface [polypeptide binding]; other site 272633001318 activator binding site; other site 272633001319 NADP binding site [chemical binding]; other site 272633001320 substrate binding site [chemical binding]; other site 272633001321 catalytic residues [active] 272633001322 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272633001323 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272633001324 active site 272633001325 catalytic tetrad [active] 272633001326 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 272633001327 DNA methylase; Region: N6_N4_Mtase; pfam01555 272633001328 DNA methylase; Region: N6_N4_Mtase; pfam01555 272633001329 DEAD-like helicases superfamily; Region: DEXDc; smart00487 272633001330 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272633001331 ATP binding site [chemical binding]; other site 272633001332 putative Mg++ binding site [ion binding]; other site 272633001333 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272633001334 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272633001335 active site 272633001336 catalytic tetrad [active] 272633001337 Predicted acetyltransferase [General function prediction only]; Region: COG5628 272633001338 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 272633001339 AAA domain; Region: AAA_23; pfam13476 272633001340 Walker A/P-loop; other site 272633001341 ATP binding site [chemical binding]; other site 272633001342 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 272633001343 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 272633001344 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 272633001345 ABC transporter signature motif; other site 272633001346 Walker B; other site 272633001347 D-loop; other site 272633001348 H-loop/switch region; other site 272633001349 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 272633001350 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 272633001351 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 272633001352 P loop; other site 272633001353 GTP binding site [chemical binding]; other site 272633001354 putative DNA-binding protein; Validated; Region: PRK00118 272633001355 WD-repeat region; Region: WD-3; pfam09765 272633001356 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 272633001357 Helix-turn-helix domain; Region: HTH_38; pfam13936 272633001358 Integrase core domain; Region: rve; pfam00665 272633001359 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 272633001360 TM2 domain; Region: TM2; pfam05154 272633001361 HNH endonuclease; Region: HNH_2; pfam13391 272633001362 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 272633001363 cofactor binding site; other site 272633001364 DNA binding site [nucleotide binding] 272633001365 substrate interaction site [chemical binding]; other site 272633001366 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 272633001367 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272633001368 active site 272633001369 motif I; other site 272633001370 motif II; other site 272633001371 ATP cone domain; Region: ATP-cone; pfam03477 272633001372 anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487 272633001373 Class III ribonucleotide reductase; Region: RNR_III; cd01675 272633001374 effector binding site; other site 272633001375 active site 272633001376 Zn binding site [ion binding]; other site 272633001377 glycine loop; other site 272633001378 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 272633001379 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272633001380 FeS/SAM binding site; other site 272633001381 coproporphyrinogen III oxidase; Provisional; Region: PRK05904 272633001382 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272633001383 FeS/SAM binding site; other site 272633001384 HemN C-terminal domain; Region: HemN_C; pfam06969 272633001385 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 272633001386 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 272633001387 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 272633001388 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 272633001389 PRD domain; Region: PRD; pfam00874 272633001390 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 272633001391 Ligand Binding Site [chemical binding]; other site 272633001392 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 272633001393 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 272633001394 tetramer interface [polypeptide binding]; other site 272633001395 TPP-binding site [chemical binding]; other site 272633001396 heterodimer interface [polypeptide binding]; other site 272633001397 phosphorylation loop region [posttranslational modification] 272633001398 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 272633001399 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 272633001400 alpha subunit interface [polypeptide binding]; other site 272633001401 TPP binding site [chemical binding]; other site 272633001402 heterodimer interface [polypeptide binding]; other site 272633001403 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272633001404 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 272633001405 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272633001406 E3 interaction surface; other site 272633001407 lipoyl attachment site [posttranslational modification]; other site 272633001408 e3 binding domain; Region: E3_binding; pfam02817 272633001409 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 272633001410 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 272633001411 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272633001412 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272633001413 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272633001414 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 272633001415 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 272633001416 catalytic residues [active] 272633001417 dimer interface [polypeptide binding]; other site 272633001418 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272633001419 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272633001420 active site 272633001421 catalytic tetrad [active] 272633001422 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 272633001423 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 272633001424 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272633001425 putative substrate translocation pore; other site 272633001426 Mycoplasma MFS transporter; Region: MFS_Mycoplasma; pfam07672 272633001427 Amino acid permease; Region: AA_permease_2; pfam13520 272633001428 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679 272633001429 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 272633001430 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272633001431 active site 272633001432 motif I; other site 272633001433 motif II; other site 272633001434 putative nicotinate-nucleotide adenylyltransferase; Validated; Region: nadD; PRK07152 272633001435 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 272633001436 active site 272633001437 (T/H)XGH motif; other site 272633001438 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272633001439 Zn2+ binding site [ion binding]; other site 272633001440 Mg2+ binding site [ion binding]; other site 272633001441 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 272633001442 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 272633001443 AAA domain; Region: AAA_14; pfam13173 272633001444 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 272633001445 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 272633001446 putative NAD(P) binding site [chemical binding]; other site 272633001447 putative substrate binding site [chemical binding]; other site 272633001448 catalytic Zn binding site [ion binding]; other site 272633001449 structural Zn binding site [ion binding]; other site 272633001450 dimer interface [polypeptide binding]; other site 272633001451 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 272633001452 active site 272633001453 dimerization interface [polypeptide binding]; other site 272633001454 Archaeal ATPase; Region: Arch_ATPase; pfam01637 272633001455 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272633001456 Walker A motif; other site 272633001457 ATP binding site [chemical binding]; other site 272633001458 Walker B motif; other site 272633001459 arginine finger; other site 272633001460 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 272633001461 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 272633001462 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272633001463 Zn2+ binding site [ion binding]; other site 272633001464 Mg2+ binding site [ion binding]; other site 272633001465 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 272633001466 synthetase active site [active] 272633001467 NTP binding site [chemical binding]; other site 272633001468 metal binding site [ion binding]; metal-binding site 272633001469 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 272633001470 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 272633001471 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 272633001472 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 272633001473 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 272633001474 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 272633001475 Helix-turn-helix domain; Region: HTH_38; pfam13936 272633001476 Integrase core domain; Region: rve; pfam00665 272633001477 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 272633001478 Helix-turn-helix domain; Region: HTH_38; pfam13936 272633001479 Integrase core domain; Region: rve; pfam00665 272633001480 Integrase core domain; Region: rve; pfam00665 272633001481 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 272633001482 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272633001483 Zn2+ binding site [ion binding]; other site 272633001484 Mg2+ binding site [ion binding]; other site 272633001485 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 272633001486 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 272633001487 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 272633001488 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 272633001489 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 272633001490 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272633001491 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 272633001492 nucleophilic elbow; other site 272633001493 catalytic triad; other site 272633001494 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 272633001495 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 272633001496 ATP binding site [chemical binding]; other site 272633001497 putative Mg++ binding site [ion binding]; other site 272633001498 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 272633001499 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272633001500 nucleotide binding region [chemical binding]; other site 272633001501 ATP-binding site [chemical binding]; other site 272633001502 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 272633001503 Integrase core domain; Region: rve; pfam00665 272633001504 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272633001505 Walker A motif; other site 272633001506 ATP binding site [chemical binding]; other site 272633001507 Walker B motif; other site 272633001508 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272633001509 Walker A/P-loop; other site 272633001510 ATP binding site [chemical binding]; other site 272633001511 Q-loop/lid; other site 272633001512 AAA domain; Region: AAA_21; pfam13304 272633001513 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272633001514 ABC transporter signature motif; other site 272633001515 Walker B; other site 272633001516 D-loop; other site 272633001517 H-loop/switch region; other site 272633001518 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272633001519 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 272633001520 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272633001521 Walker A/P-loop; other site 272633001522 ATP binding site [chemical binding]; other site 272633001523 Q-loop/lid; other site 272633001524 ABC transporter signature motif; other site 272633001525 Walker B; other site 272633001526 D-loop; other site 272633001527 H-loop/switch region; other site 272633001528 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272633001529 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 272633001530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272633001531 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 272633001532 putative PBP binding loops; other site 272633001533 dimer interface [polypeptide binding]; other site 272633001534 ABC-ATPase subunit interface; other site 272633001535 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 272633001536 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272633001537 dimer interface [polypeptide binding]; other site 272633001538 conserved gate region; other site 272633001539 putative PBP binding loops; other site 272633001540 ABC-ATPase subunit interface; other site 272633001541 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272633001542 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272633001543 Walker A/P-loop; other site 272633001544 ATP binding site [chemical binding]; other site 272633001545 Q-loop/lid; other site 272633001546 ABC transporter signature motif; other site 272633001547 Walker B; other site 272633001548 D-loop; other site 272633001549 H-loop/switch region; other site 272633001550 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 272633001551 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 272633001552 ATP binding site [chemical binding]; other site 272633001553 putative Mg++ binding site [ion binding]; other site 272633001554 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 272633001555 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 272633001556 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 272633001557 methionine sulfoxide reductase A; Provisional; Region: PRK14054 272633001558 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 272633001559 Protein phosphatase 2C; Region: PP2C; pfam00481 272633001560 active site 272633001561 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 272633001562 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272633001563 FeS/SAM binding site; other site 272633001564 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 272633001565 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 272633001566 catalytic site [active] 272633001567 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 272633001568 active site 272633001569 catalytic residues [active] 272633001570 metal binding site [ion binding]; metal-binding site 272633001571 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 272633001572 Helix-turn-helix domain; Region: HTH_38; pfam13936 272633001573 Integrase core domain; Region: rve; pfam00665 272633001574 Spc7 kinetochore protein; Region: Spc7; smart00787 272633001575 Golgi complex component 7 (COG7); Region: COG7; pfam10191 272633001576 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 272633001577 propionate/acetate kinase; Provisional; Region: PRK12379 272633001578 Integrase core domain; Region: rve; pfam00665 272633001579 Integrase core domain; Region: rve; pfam00665 272633001580 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 272633001581 peripheral dimer interface [polypeptide binding]; other site 272633001582 core dimer interface [polypeptide binding]; other site 272633001583 L10 interface [polypeptide binding]; other site 272633001584 L11 interface [polypeptide binding]; other site 272633001585 putative EF-Tu interaction site [polypeptide binding]; other site 272633001586 putative EF-G interaction site [polypeptide binding]; other site 272633001587 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 272633001588 23S rRNA interface [nucleotide binding]; other site 272633001589 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 272633001590 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 272633001591 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 272633001592 active site 272633001593 catalytic site [active] 272633001594 metal binding site [ion binding]; metal-binding site 272633001595 dimer interface [polypeptide binding]; other site 272633001596 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272633001597 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272633001598 Walker A motif; other site 272633001599 ATP binding site [chemical binding]; other site 272633001600 Walker B motif; other site 272633001601 arginine finger; other site 272633001602 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272633001603 active site 272633001604 adenylosuccinate lyase; Provisional; Region: PRK07492 272633001605 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 272633001606 tetramer interface [polypeptide binding]; other site 272633001607 active site 272633001608 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 272633001609 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 272633001610 GDP-binding site [chemical binding]; other site 272633001611 ACT binding site; other site 272633001612 IMP binding site; other site 272633001613 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 272633001614 DHH family; Region: DHH; pfam01368 272633001615 DHHA1 domain; Region: DHHA1; pfam02272 272633001616 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 272633001617 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 272633001618 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 272633001619 Ligand Binding Site [chemical binding]; other site 272633001620 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 272633001621 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 272633001622 TM-ABC transporter signature motif; other site 272633001623 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 272633001624 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 272633001625 TM-ABC transporter signature motif; other site 272633001626 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 272633001627 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272633001628 Walker A/P-loop; other site 272633001629 ATP binding site [chemical binding]; other site 272633001630 Q-loop/lid; other site 272633001631 ABC transporter signature motif; other site 272633001632 Walker B; other site 272633001633 D-loop; other site 272633001634 H-loop/switch region; other site 272633001635 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 272633001636 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 272633001637 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 272633001638 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272633001639 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 272633001640 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272633001641 active site turn [active] 272633001642 phosphorylation site [posttranslational modification] 272633001643 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 272633001644 HPr interaction site; other site 272633001645 glycerol kinase (GK) interaction site [polypeptide binding]; other site 272633001646 active site 272633001647 phosphorylation site [posttranslational modification] 272633001648 6-phosphofructokinase; Provisional; Region: PRK03202 272633001649 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 272633001650 active site 272633001651 ADP/pyrophosphate binding site [chemical binding]; other site 272633001652 dimerization interface [polypeptide binding]; other site 272633001653 allosteric effector site; other site 272633001654 fructose-1,6-bisphosphate binding site; other site 272633001655 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 272633001656 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 272633001657 DNA binding residues [nucleotide binding] 272633001658 putative dimer interface [polypeptide binding]; other site 272633001659 hypothetical protein; Validated; Region: PRK07668 272633001660 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 272633001661 active site 272633001662 catalytic triad [active] 272633001663 oxyanion hole [active] 272633001664 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 272633001665 active site 272633001666 catalytic triad [active] 272633001667 oxyanion hole [active] 272633001668 Acyltransferase family; Region: Acyl_transf_3; pfam01757 272633001669 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 272633001670 active site 272633001671 oxyanion hole [active] 272633001672 Amidinotransferase; Region: Amidinotransf; cl12043 272633001673 ornithine carbamoyltransferase; Validated; Region: PRK02102 272633001674 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 272633001675 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 272633001676 carbamate kinase; Reviewed; Region: PRK12686 272633001677 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 272633001678 putative substrate binding site [chemical binding]; other site 272633001679 nucleotide binding site [chemical binding]; other site 272633001680 nucleotide binding site [chemical binding]; other site 272633001681 homodimer interface [polypeptide binding]; other site 272633001682 Amino acid permease; Region: AA_permease_2; pfam13520 272633001683 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 272633001684 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 272633001685 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 272633001686 active site 272633001687 HIGH motif; other site 272633001688 KMSK motif region; other site 272633001689 tRNA binding surface [nucleotide binding]; other site 272633001690 DALR anticodon binding domain; Region: DALR_1; smart00836 272633001691 anticodon binding site; other site 272633001692 FtsX-like permease family; Region: FtsX; pfam02687 272633001693 Serine hydrolase; Region: Ser_hydrolase; cl17834 272633001694 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272633001695 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 272633001696 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 272633001697 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 272633001698 active site 272633001699 NAD binding site [chemical binding]; other site 272633001700 metal binding site [ion binding]; metal-binding site 272633001701 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 272633001702 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 272633001703 active site 272633001704 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 272633001705 Protein of unknown function (DUF328); Region: DUF328; pfam03883 272633001706 HTH domain; Region: HTH_11; cl17392 272633001707 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 272633001708 Integrase core domain; Region: rve; pfam00665 272633001709 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272633001710 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 272633001711 Walker A motif; other site 272633001712 ATP binding site [chemical binding]; other site 272633001713 Walker B motif; other site 272633001714 arginine finger; other site 272633001715 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; pfam07745 272633001716 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 272633001717 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 272633001718 active site 272633001719 glycerol kinase; Provisional; Region: glpK; PRK00047 272633001720 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 272633001721 N- and C-terminal domain interface [polypeptide binding]; other site 272633001722 active site 272633001723 MgATP binding site [chemical binding]; other site 272633001724 catalytic site [active] 272633001725 metal binding site [ion binding]; metal-binding site 272633001726 glycerol binding site [chemical binding]; other site 272633001727 homotetramer interface [polypeptide binding]; other site 272633001728 homodimer interface [polypeptide binding]; other site 272633001729 FBP binding site [chemical binding]; other site 272633001730 protein IIAGlc interface [polypeptide binding]; other site 272633001731 Predicted dehydrogenase [General function prediction only]; Region: COG0579 272633001732 hydroxyglutarate oxidase; Provisional; Region: PRK11728 272633001733 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 272633001734 amphipathic channel; other site 272633001735 Asn-Pro-Ala signature motifs; other site 272633001736 recombinase A; Provisional; Region: recA; PRK09354 272633001737 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 272633001738 hexamer interface [polypeptide binding]; other site 272633001739 Walker A motif; other site 272633001740 ATP binding site [chemical binding]; other site 272633001741 Walker B motif; other site 272633001742 Competence-damaged protein; Region: CinA; pfam02464 272633001743 Protein of unknown function (DUF1664); Region: DUF1664; pfam07889 272633001744 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 272633001745 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 272633001746 dimer interface [polypeptide binding]; other site 272633001747 FMN binding site [chemical binding]; other site 272633001748 NADPH bind site [chemical binding]; other site 272633001749 ribosome biogenesis GTPase YqeH; Region: GTPase_YqeH; TIGR03597 272633001750 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 272633001751 GTP/Mg2+ binding site [chemical binding]; other site 272633001752 G4 box; other site 272633001753 G5 box; other site 272633001754 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 272633001755 G1 box; other site 272633001756 G1 box; other site 272633001757 GTP/Mg2+ binding site [chemical binding]; other site 272633001758 Switch I region; other site 272633001759 G2 box; other site 272633001760 G2 box; other site 272633001761 Switch I region; other site 272633001762 G3 box; other site 272633001763 G3 box; other site 272633001764 Switch II region; other site 272633001765 Switch II region; other site 272633001766 G4 box; other site 272633001767 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 272633001768 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272633001769 active site 272633001770 motif I; other site 272633001771 motif II; other site 272633001772 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272633001773 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272633001774 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 272633001775 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 272633001776 CAP-like domain; other site 272633001777 active site 272633001778 primary dimer interface [polypeptide binding]; other site 272633001779 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272633001780 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 272633001781 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272633001782 Mg2+ binding site [ion binding]; other site 272633001783 G-X-G motif; other site 272633001784 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 272633001785 anchoring element; other site 272633001786 dimer interface [polypeptide binding]; other site 272633001787 ATP binding site [chemical binding]; other site 272633001788 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 272633001789 active site 272633001790 metal binding site [ion binding]; metal-binding site 272633001791 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 272633001792 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633001793 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633001794 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633001795 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633001796 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633001797 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633001798 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633001799 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633001800 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633001801 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633001802 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633001803 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633001804 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633001805 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 272633001806 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 272633001807 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272633001808 Walker A/P-loop; other site 272633001809 ATP binding site [chemical binding]; other site 272633001810 Q-loop/lid; other site 272633001811 ABC transporter signature motif; other site 272633001812 Walker B; other site 272633001813 D-loop; other site 272633001814 H-loop/switch region; other site 272633001815 High affinity transport system protein p37; Region: Mycoplasma_p37; pfam06646 272633001816 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633001817 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633001818 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633001819 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633001820 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633001821 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633001822 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633001823 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633001824 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633001825 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633001826 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633001827 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633001828 putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208 272633001829 oligomer interface [polypeptide binding]; other site 272633001830 flavodoxin; Provisional; Region: PRK07116 272633001831 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633001832 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633001833 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633001834 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633001835 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633001836 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633001837 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633001838 RmuC family; Region: RmuC; pfam02646 272633001839 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 272633001840 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 272633001841 folate binding site [chemical binding]; other site 272633001842 NADP+ binding site [chemical binding]; other site 272633001843 thymidylate synthase; Region: thym_sym; TIGR03284 272633001844 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 272633001845 dimerization interface [polypeptide binding]; other site 272633001846 active site 272633001847 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 272633001848 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 272633001849 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 272633001850 homodimer interface [polypeptide binding]; other site 272633001851 NADP binding site [chemical binding]; other site 272633001852 substrate binding site [chemical binding]; other site 272633001853 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 272633001854 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 272633001855 dimer interface [polypeptide binding]; other site 272633001856 PYR/PP interface [polypeptide binding]; other site 272633001857 TPP binding site [chemical binding]; other site 272633001858 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 272633001859 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 272633001860 TPP-binding site [chemical binding]; other site 272633001861 dimer interface [polypeptide binding]; other site 272633001862 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 272633001863 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 272633001864 active site 272633001865 NAD binding site [chemical binding]; other site 272633001866 metal binding site [ion binding]; metal-binding site 272633001867 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 272633001868 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272633001869 Walker A motif; other site 272633001870 ATP binding site [chemical binding]; other site 272633001871 Walker B motif; other site 272633001872 arginine finger; other site 272633001873 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 272633001874 trigger factor; Region: tig; TIGR00115 272633001875 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 272633001876 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 272633001877 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 272633001878 Protein of unknown function (DUF1600); Region: DUF1600; pfam07667 272633001879 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633001880 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633001881 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633001882 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633001883 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633001884 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633001885 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633001886 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633001887 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633001888 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633001889 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633001890 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633001891 putative transposase OrfB; Reviewed; Region: PHA02517 272633001892 HTH domain; Region: HTH_11; cl17392 272633001893 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 272633001894 Integrase core domain; Region: rve; pfam00665 272633001895 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272633001896 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 272633001897 Walker A motif; other site 272633001898 ATP binding site [chemical binding]; other site 272633001899 Walker B motif; other site 272633001900 arginine finger; other site 272633001901 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 272633001902 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 272633001903 intersubunit interface [polypeptide binding]; other site 272633001904 active site 272633001905 Zn2+ binding site [ion binding]; other site 272633001906 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 272633001907 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 272633001908 AP (apurinic/apyrimidinic) site pocket; other site 272633001909 DNA interaction; other site 272633001910 Metal-binding active site; metal-binding site 272633001911 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 272633001912 active site 272633001913 dimer interface [polypeptide binding]; other site 272633001914 magnesium binding site [ion binding]; other site 272633001915 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272633001916 active site 272633001917 phosphorylation site [posttranslational modification] 272633001918 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 272633001919 active site 272633001920 P-loop; other site 272633001921 phosphorylation site [posttranslational modification] 272633001922 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 272633001923 Phosphotriesterase family; Region: PTE; cl17343 272633001924 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: Php; COG1735 272633001925 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 272633001926 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272633001927 Walker A/P-loop; other site 272633001928 ATP binding site [chemical binding]; other site 272633001929 Q-loop/lid; other site 272633001930 ABC transporter signature motif; other site 272633001931 Walker B; other site 272633001932 D-loop; other site 272633001933 H-loop/switch region; other site 272633001934 M penetrans paralogue family 26; Region: MpPF26; pfam07666 272633001935 AAA domain; Region: AAA_14; pfam13173 272633001936 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 272633001937 Lipoprotein associated domain; Region: Lipoprotein_17; pfam04200 272633001938 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633001939 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 272633001940 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633001941 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633001942 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633001943 M penetrans paralogue family 1; Region: MpPF1; pfam07668 272633001944 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 272633001945 FeS assembly protein SufB; Region: sufB; TIGR01980 272633001946 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 272633001947 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 272633001948 trimerization site [polypeptide binding]; other site 272633001949 active site 272633001950 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 272633001951 Aminotransferase class-V; Region: Aminotran_5; pfam00266 272633001952 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272633001953 catalytic residue [active] 272633001954 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 272633001955 FeS assembly ATPase SufC; Region: sufC; TIGR01978 272633001956 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 272633001957 Walker A/P-loop; other site 272633001958 ATP binding site [chemical binding]; other site 272633001959 Q-loop/lid; other site 272633001960 ABC transporter signature motif; other site 272633001961 Walker B; other site 272633001962 D-loop; other site 272633001963 H-loop/switch region; other site 272633001964 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 272633001965 Coenzyme A binding pocket [chemical binding]; other site 272633001966 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 272633001967 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39E; cd02424 272633001968 putative active site [active] 272633001969 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 272633001970 Walker A/P-loop; other site 272633001971 ATP binding site [chemical binding]; other site 272633001972 Q-loop/lid; other site 272633001973 ABC transporter signature motif; other site 272633001974 Walker B; other site 272633001975 D-loop; other site 272633001976 H-loop/switch region; other site 272633001977 Reovirus sigma C capsid protein; Region: Reo_sigmaC; pfam04582 272633001978 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272633001979 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272633001980 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 272633001981 Walker A/P-loop; other site 272633001982 ATP binding site [chemical binding]; other site 272633001983 Q-loop/lid; other site 272633001984 ABC transporter signature motif; other site 272633001985 Walker B; other site 272633001986 D-loop; other site 272633001987 H-loop/switch region; other site 272633001988 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272633001989 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272633001990 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272633001991 Walker A/P-loop; other site 272633001992 ATP binding site [chemical binding]; other site 272633001993 Q-loop/lid; other site 272633001994 ABC transporter signature motif; other site 272633001995 Walker B; other site 272633001996 D-loop; other site 272633001997 H-loop/switch region; other site 272633001998 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 272633001999 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 272633002000 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272633002001 RNA binding surface [nucleotide binding]; other site 272633002002 Archaeal ATPase; Region: Arch_ATPase; pfam01637 272633002003 AAA ATPase domain; Region: AAA_16; pfam13191 272633002004 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 272633002005 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272633002006 active site 272633002007 phosphorylation site [posttranslational modification] 272633002008 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 272633002009 active site 272633002010 P-loop; other site 272633002011 phosphorylation site [posttranslational modification] 272633002012 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 272633002013 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 272633002014 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 272633002015 PRD domain; Region: PRD; pfam00874 272633002016 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 272633002017 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 272633002018 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 272633002019 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 272633002020 putative substrate binding site [chemical binding]; other site 272633002021 putative ATP binding site [chemical binding]; other site 272633002022 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 272633002023 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272633002024 active site 272633002025 phosphorylation site [posttranslational modification] 272633002026 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 272633002027 active site 272633002028 P-loop; other site 272633002029 phosphorylation site [posttranslational modification] 272633002030 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 272633002031 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 272633002032 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 272633002033 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 272633002034 Integrase core domain; Region: rve; pfam00665 272633002035 AAA domain; Region: AAA_14; pfam13173 272633002036 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 272633002037 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272633002038 active site 272633002039 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 272633002040 active site 272633002041 dimer interface [polypeptide binding]; other site 272633002042 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 272633002043 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 272633002044 heterodimer interface [polypeptide binding]; other site 272633002045 active site 272633002046 FMN binding site [chemical binding]; other site 272633002047 homodimer interface [polypeptide binding]; other site 272633002048 substrate binding site [chemical binding]; other site 272633002049 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 272633002050 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 272633002051 FAD binding pocket [chemical binding]; other site 272633002052 FAD binding motif [chemical binding]; other site 272633002053 phosphate binding motif [ion binding]; other site 272633002054 beta-alpha-beta structure motif; other site 272633002055 NAD binding pocket [chemical binding]; other site 272633002056 Iron coordination center [ion binding]; other site 272633002057 Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044 272633002058 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 272633002059 active site 272633002060 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 272633002061 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 272633002062 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 272633002063 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 272633002064 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272633002065 active site 272633002066 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 272633002067 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 272633002068 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 272633002069 FeS/SAM binding site; other site 272633002070 TRAM domain; Region: TRAM; pfam01938 272633002071 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 272633002072 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 272633002073 active site 272633002074 HIGH motif; other site 272633002075 dimer interface [polypeptide binding]; other site 272633002076 KMSKS motif; other site 272633002077 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272633002078 RNA binding surface [nucleotide binding]; other site 272633002079 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272633002080 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272633002081 active site 272633002082 catalytic tetrad [active] 272633002083 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 272633002084 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272633002085 S-adenosylmethionine binding site [chemical binding]; other site 272633002086 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 272633002087 prolyl-tRNA synthetase; Provisional; Region: PRK08661 272633002088 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 272633002089 dimer interface [polypeptide binding]; other site 272633002090 motif 1; other site 272633002091 active site 272633002092 motif 2; other site 272633002093 motif 3; other site 272633002094 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 272633002095 anticodon binding site; other site 272633002096 hypothetical protein; Provisional; Region: PRK12378 272633002097 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 272633002098 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272633002099 ATP binding site [chemical binding]; other site 272633002100 putative Mg++ binding site [ion binding]; other site 272633002101 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272633002102 nucleotide binding region [chemical binding]; other site 272633002103 ATP-binding site [chemical binding]; other site 272633002104 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 272633002105 recombination protein RecR; Reviewed; Region: recR; PRK00076 272633002106 RecR protein; Region: RecR; pfam02132 272633002107 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 272633002108 putative active site [active] 272633002109 putative metal-binding site [ion binding]; other site 272633002110 tetramer interface [polypeptide binding]; other site 272633002111 hypothetical protein; Provisional; Region: PRK00587 272633002112 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 272633002113 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272633002114 Walker A motif; other site 272633002115 ATP binding site [chemical binding]; other site 272633002116 DNA polymerase III subunit delta'; Validated; Region: PRK08485 272633002117 Walker B motif; other site 272633002118 arginine finger; other site 272633002119 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 272633002120 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 272633002121 active site 272633002122 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 272633002123 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 272633002124 trmE is a tRNA modification GTPase; Region: trmE; cd04164 272633002125 G1 box; other site 272633002126 GTP/Mg2+ binding site [chemical binding]; other site 272633002127 Switch I region; other site 272633002128 G2 box; other site 272633002129 Switch II region; other site 272633002130 G3 box; other site 272633002131 G4 box; other site 272633002132 G5 box; other site 272633002133 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 272633002134 DNA polymerase III subunit delta'; Validated; Region: PRK05818 272633002135 DNA polymerase III subunit delta'; Validated; Region: PRK08485 272633002136 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 272633002137 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 272633002138 TMP-binding site; other site 272633002139 ATP-binding site [chemical binding]; other site 272633002140 Bax inhibitor 1 like; Region: BaxI_1; cl17691 272633002141 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 272633002142 Phosphoglycerate kinase; Region: PGK; pfam00162 272633002143 substrate binding site [chemical binding]; other site 272633002144 hinge regions; other site 272633002145 ADP binding site [chemical binding]; other site 272633002146 catalytic site [active] 272633002147 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 272633002148 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 272633002149 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 272633002150 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 272633002151 VanD integrase, IntD, and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases including those similar to IntD, a putative integrase-like protein, a component...; Region: INT_VanD; cd01196 272633002152 Int/Topo IB signature motif; other site 272633002153 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272633002154 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272633002155 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272633002156 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 272633002157 Methyltransferase domain; Region: Methyltransf_26; pfam13659 272633002158 DEAD-like helicases superfamily; Region: DEXDc; smart00487 272633002159 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272633002160 ATP binding site [chemical binding]; other site 272633002161 putative Mg++ binding site [ion binding]; other site 272633002162 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 272633002163 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 272633002164 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 272633002165 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 272633002166 Reovirus sigma C capsid protein; Region: Reo_sigmaC; pfam04582 272633002167 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 272633002168 Uncharacterized conserved protein [Function unknown]; Region: COG0327 272633002169 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 272633002170 Family of unknown function (DUF633); Region: DUF633; pfam04816 272633002171 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 272633002172 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272633002173 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 272633002174 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 272633002175 DNA binding residues [nucleotide binding] 272633002176 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 272633002177 nucleotide binding site [chemical binding]; other site 272633002178 SulA interaction site; other site 272633002179 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 272633002180 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 272633002181 dimer interface [polypeptide binding]; other site 272633002182 putative anticodon binding site; other site 272633002183 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 272633002184 motif 1; other site 272633002185 active site 272633002186 motif 2; other site 272633002187 motif 3; other site 272633002188 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 272633002189 Part of AAA domain; Region: AAA_19; pfam13245 272633002190 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 272633002191 AAA domain; Region: AAA_12; pfam13087 272633002192 seryl-tRNA synthetase; Provisional; Region: PRK05431 272633002193 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 272633002194 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 272633002195 Peptidase family U32; Region: Peptidase_U32; pfam01136 272633002196 Peptidase family U32; Region: Peptidase_U32; pfam01136 272633002197 Methyltransferase domain; Region: Methyltransf_24; pfam13578 272633002198 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 272633002199 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 272633002200 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 272633002201 motif 1; other site 272633002202 active site 272633002203 motif 2; other site 272633002204 motif 3; other site 272633002205 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 272633002206 DHHA1 domain; Region: DHHA1; pfam02272 272633002207 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 272633002208 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 272633002209 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272633002210 active site 272633002211 motif I; other site 272633002212 motif II; other site 272633002213 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 272633002214 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 272633002215 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272633002216 Walker A/P-loop; other site 272633002217 ATP binding site [chemical binding]; other site 272633002218 Q-loop/lid; other site 272633002219 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 272633002220 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272633002221 ABC transporter signature motif; other site 272633002222 Walker B; other site 272633002223 D-loop; other site 272633002224 H-loop/switch region; other site 272633002225 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272633002226 dimer interface [polypeptide binding]; other site 272633002227 conserved gate region; other site 272633002228 putative PBP binding loops; other site 272633002229 ABC-ATPase subunit interface; other site 272633002230 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 272633002231 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272633002232 dimer interface [polypeptide binding]; other site 272633002233 conserved gate region; other site 272633002234 putative PBP binding loops; other site 272633002235 ABC-ATPase subunit interface; other site 272633002236 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 272633002237 UGMP family protein; Validated; Region: PRK09604 272633002238 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 272633002239 Mycoplasma MFS transporter; Region: MFS_Mycoplasma; pfam07672 272633002240 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 272633002241 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 272633002242 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 272633002243 Cation transport protein; Region: TrkH; cl17365 272633002244 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 272633002245 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 272633002246 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 272633002247 Formyltetrahydrofolate synthetase [Nucleotide transport and metabolism]; Region: MIS1; COG2759 272633002248 Potassium binding sites [ion binding]; other site 272633002249 Cesium cation binding sites [ion binding]; other site 272633002250 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 272633002251 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 272633002252 active site 272633002253 Zn binding site [ion binding]; other site 272633002254 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 272633002255 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272633002256 Soluble P-type ATPase [General function prediction only]; Region: COG4087 272633002257 Heavy-metal-associated domain; Region: HMA; pfam00403 272633002258 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272633002259 Walker A/P-loop; other site 272633002260 ATP binding site [chemical binding]; other site 272633002261 Q-loop/lid; other site 272633002262 Cancer susceptibility candidate 1; Region: Casc1; pfam12366 272633002263 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272633002264 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 272633002265 ABC transporter signature motif; other site 272633002266 Walker B; other site 272633002267 D-loop; other site 272633002268 H-loop/switch region; other site 272633002269 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272633002270 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272633002271 Walker A/P-loop; other site 272633002272 ATP binding site [chemical binding]; other site 272633002273 Q-loop/lid; other site 272633002274 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272633002275 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 272633002276 ABC transporter signature motif; other site 272633002277 Walker B; other site 272633002278 D-loop; other site 272633002279 H-loop/switch region; other site 272633002280 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272633002281 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 272633002282 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272633002283 dimer interface [polypeptide binding]; other site 272633002284 conserved gate region; other site 272633002285 putative PBP binding loops; other site 272633002286 ABC-ATPase subunit interface; other site 272633002287 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272633002288 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272633002289 dimer interface [polypeptide binding]; other site 272633002290 conserved gate region; other site 272633002291 putative PBP binding loops; other site 272633002292 ABC-ATPase subunit interface; other site 272633002293 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 272633002294 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272633002295 active site 272633002296 HIGH motif; other site 272633002297 nucleotide binding site [chemical binding]; other site 272633002298 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 272633002299 active site 272633002300 KMSKS motif; other site 272633002301 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 272633002302 tRNA binding surface [nucleotide binding]; other site 272633002303 anticodon binding site; other site 272633002304 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 272633002305 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272633002306 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272633002307 active site 272633002308 NusG family protein; Region: NusG_myco; TIGR01956 272633002309 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 272633002310 putative homodimer interface [polypeptide binding]; other site 272633002311 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 272633002312 heterodimer interface [polypeptide binding]; other site 272633002313 homodimer interface [polypeptide binding]; other site 272633002314 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 272633002315 Uncharacterized conserved protein [Function unknown]; Region: COG1284 272633002316 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272633002317 Protein of unknown function DUF45; Region: DUF45; pfam01863 272633002318 excinuclease ABC subunit B; Provisional; Region: PRK05298 272633002319 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272633002320 ATP binding site [chemical binding]; other site 272633002321 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272633002322 nucleotide binding region [chemical binding]; other site 272633002323 ATP-binding site [chemical binding]; other site 272633002324 Ultra-violet resistance protein B; Region: UvrB; pfam12344 272633002325 UvrB/uvrC motif; Region: UVR; pfam02151 272633002326 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 272633002327 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 272633002328 putative active site [active] 272633002329 metal binding site [ion binding]; metal-binding site 272633002330 homodimer binding site [polypeptide binding]; other site 272633002331 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 272633002332 Part of AAA domain; Region: AAA_19; pfam13245 272633002333 Family description; Region: UvrD_C_2; pfam13538 272633002334 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272633002335 active site 272633002336 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 272633002337 multifunctional aminopeptidase A; Provisional; Region: PRK00913 272633002338 interface (dimer of trimers) [polypeptide binding]; other site 272633002339 Substrate-binding/catalytic site; other site 272633002340 Zn-binding sites [ion binding]; other site 272633002341 GrpE; Region: GrpE; pfam01025 272633002342 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 272633002343 dimer interface [polypeptide binding]; other site 272633002344 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 272633002345 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 272633002346 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272633002347 HSP70 interaction site [polypeptide binding]; other site 272633002348 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 272633002349 Zn binding sites [ion binding]; other site 272633002350 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 272633002351 dimer interface [polypeptide binding]; other site 272633002352 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 272633002353 Low molecular weight phosphatase family; Region: LMWPc; cd00115 272633002354 active site 272633002355 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 272633002356 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 272633002357 active site 272633002358 FMN binding site [chemical binding]; other site 272633002359 substrate binding site [chemical binding]; other site 272633002360 homotetramer interface [polypeptide binding]; other site 272633002361 catalytic residue [active] 272633002362 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 272633002363 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 272633002364 Protein of unknown function (DUF3196); Region: DUF3196; pfam11428 272633002365 Protein of unknown function (DUF402); Region: DUF402; cl00979 272633002366 SWIM zinc finger; Region: SWIM; pfam04434 272633002367 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 272633002368 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 272633002369 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272633002370 ATP binding site [chemical binding]; other site 272633002371 putative Mg++ binding site [ion binding]; other site 272633002372 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272633002373 nucleotide binding region [chemical binding]; other site 272633002374 ATP-binding site [chemical binding]; other site 272633002375 GTPase RsgA; Reviewed; Region: PRK00098 272633002376 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272633002377 RNA binding site [nucleotide binding]; other site 272633002378 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 272633002379 GTPase/Zn-binding domain interface [polypeptide binding]; other site 272633002380 GTP/Mg2+ binding site [chemical binding]; other site 272633002381 G4 box; other site 272633002382 G5 box; other site 272633002383 G1 box; other site 272633002384 Switch I region; other site 272633002385 G2 box; other site 272633002386 G3 box; other site 272633002387 Switch II region; other site 272633002388 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272633002389 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272633002390 active site 272633002391 ATP binding site [chemical binding]; other site 272633002392 substrate binding site [chemical binding]; other site 272633002393 activation loop (A-loop); other site 272633002394 M penetrans paralogue family 26; Region: MpPF26; pfam07666 272633002395 M penetrans paralogue family 26; Region: MpPF26; pfam07666 272633002396 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 272633002397 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 272633002398 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 272633002399 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 272633002400 Pertussis toxin, subunit 1; Region: Pertussis_S1; cl03779 272633002401 flavodoxin FldA; Validated; Region: PRK09267 272633002402 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 272633002403 23S rRNA binding site [nucleotide binding]; other site 272633002404 L21 binding site [polypeptide binding]; other site 272633002405 L13 binding site [polypeptide binding]; other site 272633002406 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 272633002407 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 272633002408 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 272633002409 DNA polymerase III PolC; Validated; Region: polC; PRK00448 272633002410 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 272633002411 generic binding surface II; other site 272633002412 generic binding surface I; other site 272633002413 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 272633002414 active site 272633002415 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 272633002416 active site 272633002417 catalytic site [active] 272633002418 substrate binding site [chemical binding]; other site 272633002419 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 272633002420 ribosomal protein S21; Region: S21p; TIGR00030 272633002421 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 272633002422 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 272633002423 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 272633002424 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 272633002425 putative tRNA-binding site [nucleotide binding]; other site 272633002426 B3/4 domain; Region: B3_4; pfam03483 272633002427 tRNA synthetase B5 domain; Region: B5; cl08394 272633002428 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 272633002429 motif 1; other site 272633002430 dimer interface [polypeptide binding]; other site 272633002431 active site 272633002432 motif 2; other site 272633002433 motif 3; other site 272633002434 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 272633002435 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 272633002436 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 272633002437 dimer interface [polypeptide binding]; other site 272633002438 motif 1; other site 272633002439 active site 272633002440 motif 2; other site 272633002441 motif 3; other site 272633002442 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 272633002443 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 272633002444 active site 272633002445 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272633002446 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 272633002447 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272633002448 active site 272633002449 nucleotide binding site [chemical binding]; other site 272633002450 HIGH motif; other site 272633002451 KMSKS motif; other site 272633002452 Riboflavin kinase; Region: Flavokinase; pfam01687 272633002453 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 272633002454 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 272633002455 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272633002456 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 272633002457 PhoU domain; Region: PhoU; pfam01895 272633002458 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 272633002459 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 272633002460 Walker A/P-loop; other site 272633002461 ATP binding site [chemical binding]; other site 272633002462 Q-loop/lid; other site 272633002463 ABC transporter signature motif; other site 272633002464 Walker B; other site 272633002465 D-loop; other site 272633002466 H-loop/switch region; other site 272633002467 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272633002468 dimer interface [polypeptide binding]; other site 272633002469 conserved gate region; other site 272633002470 putative PBP binding loops; other site 272633002471 ABC-ATPase subunit interface; other site 272633002472 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 272633002473 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272633002474 dimer interface [polypeptide binding]; other site 272633002475 conserved gate region; other site 272633002476 putative PBP binding loops; other site 272633002477 ABC-ATPase subunit interface; other site 272633002478 PBP superfamily domain; Region: PBP_like_2; cl17296 272633002479 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 272633002480 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272633002481 catalytic residue [active] 272633002482 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 272633002483 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 272633002484 active site 272633002485 HIGH motif; other site 272633002486 KMSKS motif; other site 272633002487 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 272633002488 tRNA binding surface [nucleotide binding]; other site 272633002489 anticodon binding site; other site 272633002490 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 272633002491 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 272633002492 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 272633002493 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 272633002494 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 272633002495 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 272633002496 putative tRNA-binding site [nucleotide binding]; other site 272633002497 nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188 272633002498 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571 272633002499 active site 272633002500 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 272633002501 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 272633002502 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 272633002503 putative active site [active] 272633002504 putative metal binding site [ion binding]; other site 272633002505 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 272633002506 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 272633002507 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 272633002508 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272633002509 active site 272633002510 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 272633002511 Bacterial RNase HI containing a hybrid binding domain (HBD) at the N-terminus; Region: RNase_HI_bacteria_HBD; cd09277 272633002512 RNA/DNA hybrid binding site [nucleotide binding]; other site 272633002513 active site 272633002514 Protein of unknown function (DUF1600); Region: DUF1600; pfam07667 272633002515 Phosphotransferase enzyme family; Region: APH; pfam01636 272633002516 active site 272633002517 substrate binding site [chemical binding]; other site 272633002518 ATP binding site [chemical binding]; other site 272633002519 Choline/ethanolamine kinase; Region: Choline_kinase; pfam01633 272633002520 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 272633002521 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 272633002522 nucleotide binding site [chemical binding]; other site 272633002523 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 272633002524 active site 272633002525 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 272633002526 catalytic tetrad [active] 272633002527 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 272633002528 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 272633002529 active site 272633002530 catalytic site [active] 272633002531 substrate binding site [chemical binding]; other site 272633002532 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 272633002533 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 272633002534 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 272633002535 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 272633002536 catalytic residue [active] 272633002537 putative FPP diphosphate binding site; other site 272633002538 putative FPP binding hydrophobic cleft; other site 272633002539 dimer interface [polypeptide binding]; other site 272633002540 putative IPP diphosphate binding site; other site 272633002541 ribosome recycling factor; Reviewed; Region: frr; PRK00083 272633002542 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 272633002543 hinge region; other site 272633002544 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 272633002545 putative nucleotide binding site [chemical binding]; other site 272633002546 uridine monophosphate binding site [chemical binding]; other site 272633002547 homohexameric interface [polypeptide binding]; other site 272633002548 elongation factor Ts; Provisional; Region: tsf; PRK09377 272633002549 UBA/TS-N domain; Region: UBA; pfam00627 272633002550 Elongation factor TS; Region: EF_TS; pfam00889 272633002551 Elongation factor TS; Region: EF_TS; pfam00889 272633002552 Protein of unknown function (DUF1600); Region: DUF1600; pfam07667 272633002553 Transposase, Mutator family; Region: Transposase_mut; pfam00872 272633002554 MULE transposase domain; Region: MULE; pfam10551 272633002555 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 272633002556 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272633002557 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 272633002558 NAD binding site [chemical binding]; other site 272633002559 dimer interface [polypeptide binding]; other site 272633002560 substrate binding site [chemical binding]; other site 272633002561 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK13964 272633002562 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272633002563 active site 272633002564 nucleotide binding site [chemical binding]; other site 272633002565 HIGH motif; other site 272633002566 KMSKS motif; other site 272633002567 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 272633002568 rRNA interaction site [nucleotide binding]; other site 272633002569 S8 interaction site; other site 272633002570 putative laminin-1 binding site; other site 272633002571 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 272633002572 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 272633002573 DNA-binding site [nucleotide binding]; DNA binding site 272633002574 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 272633002575 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 272633002576 active site turn [active] 272633002577 phosphorylation site [posttranslational modification] 272633002578 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272633002579 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 272633002580 glycerol kinase (GK) interaction site [polypeptide binding]; other site 272633002581 HPr interaction site; other site 272633002582 active site 272633002583 phosphorylation site [posttranslational modification] 272633002584 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 272633002585 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 272633002586 substrate binding [chemical binding]; other site 272633002587 active site 272633002588 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 272633002589 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272633002590 nucleotide binding site [chemical binding]; other site 272633002591 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 272633002592 AAA domain; Region: AAA_14; pfam13173 272633002593 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950 272633002594 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 272633002595 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 272633002596 dimerization interface 3.5A [polypeptide binding]; other site 272633002597 active site 272633002598 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 272633002599 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 272633002600 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13651 272633002601 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272633002602 Walker A/P-loop; other site 272633002603 ATP binding site [chemical binding]; other site 272633002604 Q-loop/lid; other site 272633002605 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 272633002606 ABC transporter signature motif; other site 272633002607 Walker B; other site 272633002608 D-loop; other site 272633002609 H-loop/switch region; other site 272633002610 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13632 272633002611 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 272633002612 Walker A/P-loop; other site 272633002613 ATP binding site [chemical binding]; other site 272633002614 Q-loop/lid; other site 272633002615 ABC transporter signature motif; other site 272633002616 Walker B; other site 272633002617 D-loop; other site 272633002618 H-loop/switch region; other site 272633002619 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 272633002620 Helix-turn-helix domain; Region: HTH_38; pfam13936 272633002621 Integrase core domain; Region: rve; pfam00665 272633002622 HNH endonuclease; Region: HNH_2; pfam13391 272633002623 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 272633002624 cofactor binding site; other site 272633002625 DNA binding site [nucleotide binding] 272633002626 substrate interaction site [chemical binding]; other site 272633002627 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 272633002628 Domain of unknown function (DUF4420); Region: DUF4420; pfam14390 272633002629 Z1 domain; Region: Z1; pfam10593 272633002630 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 272633002631 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 272633002632 17-beta-hydroxysteroid dehydrogenases (17beta-HSDs) types -1, -3, and -12, -like, classical (c) SDRs; Region: 17beta-HSD1_like_SDR_c; cd05356 272633002633 putative NAD(P) binding site [chemical binding]; other site 272633002634 active site 272633002635 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 272633002636 trimer interface [polypeptide binding]; other site 272633002637 active site 272633002638 G bulge; other site 272633002639 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 272633002640 trimer interface [polypeptide binding]; other site 272633002641 active site 272633002642 G bulge; other site 272633002643 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 272633002644 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 272633002645 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 272633002646 alphaNTD - beta interaction site [polypeptide binding]; other site 272633002647 alphaNTD homodimer interface [polypeptide binding]; other site 272633002648 alphaNTD - beta' interaction site [polypeptide binding]; other site 272633002649 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 272633002650 30S ribosomal protein S11; Validated; Region: PRK05309 272633002651 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 272633002652 30S ribosomal protein S13; Region: bact_S13; TIGR03631 272633002653 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 272633002654 rRNA binding site [nucleotide binding]; other site 272633002655 predicted 30S ribosome binding site; other site 272633002656 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 272633002657 active site 272633002658 adenylate kinase; Region: adk; TIGR01351 272633002659 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 272633002660 AMP-binding site [chemical binding]; other site 272633002661 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 272633002662 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 272633002663 SecY translocase; Region: SecY; pfam00344 272633002664 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 272633002665 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 272633002666 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 272633002667 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 272633002668 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 272633002669 23S rRNA interface [nucleotide binding]; other site 272633002670 L21e interface [polypeptide binding]; other site 272633002671 5S rRNA interface [nucleotide binding]; other site 272633002672 L27 interface [polypeptide binding]; other site 272633002673 L5 interface [polypeptide binding]; other site 272633002674 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 272633002675 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 272633002676 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 272633002677 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 272633002678 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 272633002679 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 272633002680 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 272633002681 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 272633002682 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 272633002683 RNA binding site [nucleotide binding]; other site 272633002684 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 272633002685 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 272633002686 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 272633002687 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 272633002688 G-X-X-G motif; other site 272633002689 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 272633002690 Uncharacterized conserved protein [Function unknown]; Region: COG4933 272633002691 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 272633002692 23S rRNA interface [nucleotide binding]; other site 272633002693 putative translocon interaction site; other site 272633002694 signal recognition particle (SRP54) interaction site; other site 272633002695 L23 interface [polypeptide binding]; other site 272633002696 trigger factor interaction site; other site 272633002697 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 272633002698 23S rRNA interface [nucleotide binding]; other site 272633002699 5S rRNA interface [nucleotide binding]; other site 272633002700 putative antibiotic binding site [chemical binding]; other site 272633002701 L25 interface [polypeptide binding]; other site 272633002702 L27 interface [polypeptide binding]; other site 272633002703 50S ribosomal protein L22/unknown domain fusion protein; Provisional; Region: PRK12279 272633002704 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 272633002705 putative translocon binding site; other site 272633002706 protein-rRNA interface [nucleotide binding]; other site 272633002707 Uncharacterized conserved protein [Function unknown]; Region: COG4933 272633002708 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 272633002709 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 272633002710 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 272633002711 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 272633002712 50S ribosomal protein L23; Reviewed; Region: rplW; PRK12280 272633002713 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 272633002714 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 272633002715 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 272633002716 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272633002717 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 272633002718 active site 272633002719 motif I; other site 272633002720 motif II; other site 272633002721 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 272633002722 Type III pantothenate kinase; Region: Pan_kinase; pfam03309 272633002723 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 272633002724 RNA/DNA hybrid binding site [nucleotide binding]; other site 272633002725 active site 272633002726 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272633002727 active site 272633002728 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 272633002729 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272633002730 Walker A motif; other site 272633002731 ATP binding site [chemical binding]; other site 272633002732 Walker B motif; other site 272633002733 arginine finger; other site 272633002734 Peptidase family M41; Region: Peptidase_M41; pfam01434 272633002735 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272633002736 active site 272633002737 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 272633002738 homotrimer interaction site [polypeptide binding]; other site 272633002739 zinc binding site [ion binding]; other site 272633002740 CDP-binding sites; other site 272633002741 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272633002742 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272633002743 Walker A/P-loop; other site 272633002744 ATP binding site [chemical binding]; other site 272633002745 Q-loop/lid; other site 272633002746 ABC transporter signature motif; other site 272633002747 Walker B; other site 272633002748 D-loop; other site 272633002749 H-loop/switch region; other site 272633002750 FtsX-like permease family; Region: FtsX; pfam02687 272633002751 FtsX-like permease family; Region: FtsX; pfam02687 272633002752 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272633002753 active site 272633002754 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 272633002755 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 272633002756 phosphate binding site [ion binding]; other site 272633002757 Thymidine kinase [Nucleotide transport and metabolism]; Region: Tdk; COG1435 272633002758 GTP-binding protein YchF; Reviewed; Region: PRK09601 272633002759 YchF GTPase; Region: YchF; cd01900 272633002760 G1 box; other site 272633002761 GTP/Mg2+ binding site [chemical binding]; other site 272633002762 Switch I region; other site 272633002763 G2 box; other site 272633002764 Switch II region; other site 272633002765 G3 box; other site 272633002766 G4 box; other site 272633002767 G5 box; other site 272633002768 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 272633002769 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 272633002770 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 272633002771 intersubunit interface [polypeptide binding]; other site 272633002772 active site 272633002773 zinc binding site [ion binding]; other site 272633002774 Na+ binding site [ion binding]; other site 272633002775 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 272633002776 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 272633002777 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272633002778 Zn2+ binding site [ion binding]; other site 272633002779 Mg2+ binding site [ion binding]; other site 272633002780 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 272633002781 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 272633002782 HIGH motif; other site 272633002783 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 272633002784 active site 272633002785 KMSKS motif; other site 272633002786 hypothetical protein; Provisional; Region: PRK05905 272633002787 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 272633002788 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 272633002789 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272633002790 S-adenosylmethionine binding site [chemical binding]; other site 272633002791 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02201 272633002792 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 272633002793 Ribonuclease P; Region: Ribonuclease_P; pfam00825 272633002794 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399