-- dump date 20140619_161656 -- class Genbank::misc_feature -- table misc_feature_note -- id note 272634000001 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 272634000002 DNA polymerase III beta subunit; Region: POL3Bc; smart00480 272634000003 putative DNA binding surface [nucleotide binding]; other site 272634000004 dimer interface [polypeptide binding]; other site 272634000005 beta-clamp/clamp loader binding surface; other site 272634000006 beta-clamp/translesion DNA polymerase binding surface; other site 272634000007 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 272634000008 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272634000009 HSP70 interaction site [polypeptide binding]; other site 272634000010 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 272634000011 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272634000012 ATP binding site [chemical binding]; other site 272634000013 Mg2+ binding site [ion binding]; other site 272634000014 G-X-G motif; other site 272634000015 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 272634000016 anchoring element; other site 272634000017 dimer interface [polypeptide binding]; other site 272634000018 ATP binding site [chemical binding]; other site 272634000019 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 272634000020 active site 272634000021 putative metal-binding site [ion binding]; other site 272634000022 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 272634000023 DNA gyrase, A subunit; Region: gyrA; TIGR01063 272634000024 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 272634000025 CAP-like domain; other site 272634000026 active site 272634000027 primary dimer interface [polypeptide binding]; other site 272634000028 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272634000029 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272634000030 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272634000031 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272634000032 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272634000033 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 272634000034 seryl-tRNA synthetase; Region: serS; TIGR00414 272634000035 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 272634000036 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 272634000037 dimer interface [polypeptide binding]; other site 272634000038 active site 272634000039 motif 1; other site 272634000040 motif 2; other site 272634000041 motif 3; other site 272634000042 thymidylate kinase; Region: DTMP_kinase; TIGR00041 272634000043 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 272634000044 TMP-binding site; other site 272634000045 ATP-binding site [chemical binding]; other site 272634000046 DNA polymerase III subunit delta'; Validated; Region: PRK05818 272634000047 DNA polymerase III subunit delta'; Validated; Region: PRK08485 272634000048 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 272634000049 tRNA modification GTPase TrmE; Region: mnmE_trmE_thdF; TIGR00450 272634000050 trmE is a tRNA modification GTPase; Region: trmE; cd04164 272634000051 G1 box; other site 272634000052 GTP/Mg2+ binding site [chemical binding]; other site 272634000053 Switch I region; other site 272634000054 G2 box; other site 272634000055 Switch II region; other site 272634000056 G3 box; other site 272634000057 G4 box; other site 272634000058 G5 box; other site 272634000059 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 272634000060 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 272634000061 active site 272634000062 Protein of unknown function DUF16; Region: DUF16; pfam01519 272634000063 Lipoprotein; Region: Lipoprotein_3; pfam00938 272634000064 Lipoprotein; Region: Lipoprotein_3; pfam00938 272634000065 Protein of unknown function DUF16; Region: DUF16; pfam01519 272634000066 DNA primase-related protein; Region: MG010; TIGR00646 272634000067 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 272634000068 active site 272634000069 metal binding site [ion binding]; metal-binding site 272634000070 interdomain interaction site; other site 272634000071 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 272634000072 ATP-grasp domain; Region: ATP-grasp_4; cl17255 272634000073 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 272634000074 RimK-like ATP-grasp domain; Region: RimK; pfam08443 272634000075 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 272634000076 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 272634000077 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 272634000078 NAD(P) binding pocket [chemical binding]; other site 272634000079 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272634000080 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272634000081 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272634000082 Walker A/P-loop; other site 272634000083 ATP binding site [chemical binding]; other site 272634000084 Q-loop/lid; other site 272634000085 ABC transporter signature motif; other site 272634000086 Walker B; other site 272634000087 D-loop; other site 272634000088 H-loop/switch region; other site 272634000089 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 272634000090 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 272634000091 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 272634000092 Walker A/P-loop; other site 272634000093 ATP binding site [chemical binding]; other site 272634000094 Q-loop/lid; other site 272634000095 ABC transporter signature motif; other site 272634000096 Walker B; other site 272634000097 D-loop; other site 272634000098 H-loop/switch region; other site 272634000099 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 272634000100 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272634000101 ATP binding site [chemical binding]; other site 272634000102 putative Mg++ binding site [ion binding]; other site 272634000103 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272634000104 nucleotide binding region [chemical binding]; other site 272634000105 ATP-binding site [chemical binding]; other site 272634000106 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 272634000107 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272634000108 HSP70 interaction site [polypeptide binding]; other site 272634000109 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 272634000110 Zn binding sites [ion binding]; other site 272634000111 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 272634000112 dimer interface [polypeptide binding]; other site 272634000113 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272634000114 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 272634000115 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 272634000116 methionyl-tRNA synthetase; Region: metG; TIGR00398 272634000117 active site 272634000118 HIGH motif; other site 272634000119 KMSKS motif; other site 272634000120 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 272634000121 tRNA binding surface [nucleotide binding]; other site 272634000122 anticodon binding site; other site 272634000123 DNA-directed RNA polymerase, delta subunit [Transcription]; Region: RpoE; COG3343 272634000124 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 272634000125 intersubunit interface [polypeptide binding]; other site 272634000126 active site 272634000127 zinc binding site [ion binding]; other site 272634000128 Na+ binding site [ion binding]; other site 272634000129 GTP-binding protein YchF; Reviewed; Region: PRK09601 272634000130 YchF GTPase; Region: YchF; cd01900 272634000131 G1 box; other site 272634000132 GTP/Mg2+ binding site [chemical binding]; other site 272634000133 Switch I region; other site 272634000134 G2 box; other site 272634000135 Switch II region; other site 272634000136 G3 box; other site 272634000137 G4 box; other site 272634000138 G5 box; other site 272634000139 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 272634000140 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 272634000141 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272634000142 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272634000143 active site 272634000144 elongation factor P; Validated; Region: PRK00529 272634000145 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 272634000146 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 272634000147 RNA binding site [nucleotide binding]; other site 272634000148 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 272634000149 RNA binding site [nucleotide binding]; other site 272634000150 Domain of unknown function (DUF1948); Region: DUF1948; pfam09185 272634000151 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 272634000152 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 272634000153 conserved cys residue [active] 272634000154 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272634000155 active site 272634000156 DNA polymerase III, alpha subunit (gram-positive type) [DNA replication, recombination, and repair]; Region: PolC; COG2176 272634000157 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 272634000158 generic binding surface II; other site 272634000159 generic binding surface I; other site 272634000160 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 272634000161 active site 272634000162 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 272634000163 active site 272634000164 catalytic site [active] 272634000165 substrate binding site [chemical binding]; other site 272634000166 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 272634000167 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; cl19160 272634000168 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 272634000169 MG032/MG096/MG288 family 2; Region: DUF240; pfam03086 272634000170 TolA protein; Region: tolA_full; TIGR02794 272634000171 MG032/MG096/MG288 family 1; Region: DUF237; pfam03072 272634000172 MG032/MG096/MG288 family 2; Region: DUF240; pfam03086 272634000173 Glutamine-rich N-terminal helical domain of various Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9); Region: ClassIIa_HDAC_Gln-rich-N; cl13614 272634000174 MG032/MG096/MG288 family 1; Region: DUF237; pfam03072 272634000175 Protein of unknown function DUF16; Region: DUF16; pfam01519 272634000176 MG032/MG096/MG288 family 2; Region: DUF240; pfam03086 272634000177 MG032/MG096/MG288 family 1; Region: DUF237; pfam03072 272634000178 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 272634000179 amphipathic channel; other site 272634000180 Asn-Pro-Ala signature motifs; other site 272634000181 Thymidine kinase [Nucleotide transport and metabolism]; Region: Tdk; COG1435 272634000182 Histidyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: HisS; COG0124 272634000183 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 272634000184 dimer interface [polypeptide binding]; other site 272634000185 motif 1; other site 272634000186 active site 272634000187 motif 2; other site 272634000188 motif 3; other site 272634000189 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 272634000190 anticodon binding site; other site 272634000191 aspartyl-tRNA synthetase, bacterial type; Region: aspS_bact; TIGR00459 272634000192 Asp_Lys_Asn_RS_N: N-terminal, anticodon recognition domain of class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop. Class 2b aaRSs include the homodimeric aspartyl-; Region: Asp_Lys_Asn_RS_N; cl19106 272634000193 Dimer interface [polypeptide binding]; other site 272634000194 anticodon binding site; other site 272634000195 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 272634000196 homodimer interface [polypeptide binding]; other site 272634000197 motif 1; other site 272634000198 active site 272634000199 motif 2; other site 272634000200 motif 3; other site 272634000201 Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488 272634000202 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 272634000203 active site 272634000204 MG032/MG096/MG288 family 2; Region: DUF240; pfam03086 272634000205 MG032/MG096/MG288 family 1; Region: DUF237; pfam03072 272634000206 MG032/MG096/MG288 family 2; Region: DUF240; pfam03086 272634000207 Geminin; Region: Geminin; pfam07412 272634000208 MG032/MG096/MG288 family 1; Region: DUF237; pfam03072 272634000209 glycerol kinase; Provisional; Region: glpK; PRK00047 272634000210 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 272634000211 N- and C-terminal domain interface [polypeptide binding]; other site 272634000212 active site 272634000213 MgATP binding site [chemical binding]; other site 272634000214 catalytic site [active] 272634000215 metal binding site [ion binding]; metal-binding site 272634000216 glycerol binding site [chemical binding]; other site 272634000217 homotetramer interface [polypeptide binding]; other site 272634000218 homodimer interface [polypeptide binding]; other site 272634000219 FBP binding site [chemical binding]; other site 272634000220 protein IIAGlc interface [polypeptide binding]; other site 272634000221 Predicted dehydrogenase [General function prediction only]; Region: COG0579 272634000222 hydroxyglutarate oxidase; Provisional; Region: PRK11728; cl19156 272634000223 Basic membrane protein; Region: Bmp; pfam02608 272634000224 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 272634000225 dimerization domain swap beta strand [polypeptide binding]; other site 272634000226 regulatory protein interface [polypeptide binding]; other site 272634000227 active site 272634000228 regulatory phosphorylation site [posttranslational modification]; other site 272634000229 Lipoprotein; Region: Lipoprotein_3; pfam00938 272634000230 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 272634000231 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272634000232 Walker A/P-loop; other site 272634000233 ATP binding site [chemical binding]; other site 272634000234 Q-loop/lid; other site 272634000235 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; cl19901 272634000236 ABC transporter signature motif; other site 272634000237 Walker B; other site 272634000238 D-loop; other site 272634000239 H-loop/switch region; other site 272634000240 TOBE domain; Region: TOBE_2; pfam08402 272634000241 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 272634000242 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272634000243 dimer interface [polypeptide binding]; other site 272634000244 conserved gate region; other site 272634000245 putative PBP binding loops; other site 272634000246 ABC-ATPase subunit interface; other site 272634000247 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 272634000248 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272634000249 dimer interface [polypeptide binding]; other site 272634000250 conserved gate region; other site 272634000251 putative PBP binding loops; other site 272634000252 ABC-ATPase subunit interface; other site 272634000253 Hypothetical lipoprotein (MG045 family); Region: Lipoprotein_8; pfam02030 272634000254 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 272634000255 metallohydrolase, glycoprotease/Kae1 family; Region: gcp_kae1; TIGR00329 272634000256 S-adenosylmethionine synthetase [Coenzyme metabolism]; Region: MetK; COG0192 272634000257 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 272634000258 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 272634000259 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 272634000260 Signal recognition particle GTPase [Intracellular trafficking and secretion]; Region: Ffh; COG0541 272634000261 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 272634000262 SRP54-type protein, GTPase domain; Region: SRP54; pfam00448 272634000263 Signal peptide binding domain; Region: SRP_SPB; pfam02978 272634000264 purine-nucleoside phosphorylase, family 1 (deoD); Region: deoD; TIGR00107 272634000265 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 272634000266 intersubunit interface [polypeptide binding]; other site 272634000267 active site 272634000268 catalytic residue [active] 272634000269 Thymidine phosphorylase [Nucleotide transport and metabolism]; Region: DeoA; COG0213 272634000270 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 272634000271 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 272634000272 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 272634000273 Cytidine deaminase [Nucleotide transport and metabolism]; Region: Cdd; COG0295 272634000274 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 272634000275 active site 272634000276 catalytic motif [active] 272634000277 Zn binding site [ion binding]; other site 272634000278 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 272634000279 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 272634000280 active site 272634000281 substrate binding site [chemical binding]; other site 272634000282 metal binding site [ion binding]; metal-binding site 272634000283 NusG family protein; Region: NusG_myco; TIGR01956 272634000284 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 272634000285 putative homodimer interface [polypeptide binding]; other site 272634000286 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 272634000287 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 272634000288 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 272634000289 putative SAM binding site [chemical binding]; other site 272634000290 putative homodimer interface [polypeptide binding]; other site 272634000291 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 272634000292 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 272634000293 putative active site [active] 272634000294 putative metal binding site [ion binding]; other site 272634000295 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 272634000296 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK00553 272634000297 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 272634000298 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272634000299 active site 272634000300 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 272634000301 SmpB-tmRNA interface; other site 272634000302 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272634000303 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272634000304 active site 272634000305 Mycoplasma MFS transporter; Region: MFS_Mycoplasma; pfam07672 272634000306 Mycoplasma MFS transporter; Region: MFS_Mycoplasma; pfam07672 272634000307 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272634000308 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 272634000309 active site 272634000310 phosphorylation site [posttranslational modification] 272634000311 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 272634000312 active site 272634000313 P-loop; other site 272634000314 phosphorylation site [posttranslational modification] 272634000315 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 272634000316 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 272634000317 putative substrate binding site [chemical binding]; other site 272634000318 putative ATP binding site [chemical binding]; other site 272634000319 FtsX-like permease family; Region: FtsX; pfam02687 272634000320 FtsX-like permease family; Region: FtsX; pfam02687 272634000321 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272634000322 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272634000323 Walker A/P-loop; other site 272634000324 ATP binding site [chemical binding]; other site 272634000325 Q-loop/lid; other site 272634000326 ABC transporter signature motif; other site 272634000327 Walker B; other site 272634000328 D-loop; other site 272634000329 H-loop/switch region; other site 272634000330 transketolase, bacterial and yeast; Region: tktlase_bact; TIGR00232 272634000331 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 272634000332 TPP-binding site [chemical binding]; other site 272634000333 dimer interface [polypeptide binding]; other site 272634000334 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 272634000335 PYR/PP interface [polypeptide binding]; other site 272634000336 dimer interface [polypeptide binding]; other site 272634000337 TPP binding site [chemical binding]; other site 272634000338 Putative peptidase (DUF31); Region: DUF31; pfam01732 272634000339 Peptidase S7, Flavivirus NS3 serine protease; Region: Peptidase_S7; pfam00949 272634000340 Putative peptidase (DUF31); Region: DUF31; pfam01732 272634000341 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 272634000342 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272634000343 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272634000344 Protein of unknown function DUF16; Region: DUF16; pfam01519 272634000345 Amino acid permease; Region: AA_permease_2; pfam13520 272634000346 Amino acid permease; Region: AA_permease_2; pfam13520 272634000347 Protein of unknown function DUF16; Region: DUF16; pfam01519 272634000348 Trypsin-sensitive surface-exposed protein; Region: CytadhesinP1; pfam12378 272634000349 Trypsin-sensitive surface-exposed protein; Region: CytadhesinP1; pfam12378 272634000350 Protein of unknown function DUF16; Region: DUF16; pfam01519 272634000351 phenylalanyl-tRNA synthetase, alpha subunit; Region: pheS; TIGR00468 272634000352 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 272634000353 dimer interface [polypeptide binding]; other site 272634000354 motif 1; other site 272634000355 active site 272634000356 motif 2; other site 272634000357 motif 3; other site 272634000358 phenylalanyl-tRNA synthetase, beta subunit, non-spirochete bacterial; Region: pheT_bact; TIGR00472 272634000359 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 272634000360 putative tRNA-binding site [nucleotide binding]; other site 272634000361 B3/4 domain; Region: B3_4; pfam03483 272634000362 tRNA synthetase B5 domain; Region: B5; smart00874 272634000363 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 272634000364 dimer interface [polypeptide binding]; other site 272634000365 motif 1; other site 272634000366 motif 3; other site 272634000367 motif 2; other site 272634000368 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 272634000369 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 272634000370 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 272634000371 Predicted helicase [General function prediction only]; Region: COG4889 272634000372 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 272634000373 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 272634000374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272634000375 Choline/Carnitine o-acyltransferase; Region: Carn_acyltransf; pfam00755 272634000376 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 272634000377 translation initiation factor IF-3; Region: infC; TIGR00168 272634000378 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 272634000379 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 272634000380 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 272634000381 23S rRNA binding site [nucleotide binding]; other site 272634000382 L21 binding site [polypeptide binding]; other site 272634000383 L13 binding site [polypeptide binding]; other site 272634000384 Ribonuclease HIII [DNA replication, recombination, and repair]; Region: RnhC; COG1039 272634000385 Bacterial type 2 ribonuclease, HII and HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 272634000386 RNA/DNA hybrid binding site [nucleotide binding]; other site 272634000387 active site 272634000388 terminal organelle assembly protein TopJ; Region: termin_org_DnaJ; TIGR03835 272634000389 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 272634000390 HSP70 interaction site [polypeptide binding]; other site 272634000391 EAGR box; Region: EAGR_box; TIGR03834 272634000392 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 272634000393 substrate binding site [polypeptide binding]; other site 272634000394 dimer interface [polypeptide binding]; other site 272634000395 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 272634000396 dimer interface [polypeptide binding]; other site 272634000397 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 272634000398 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 272634000399 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 272634000400 ATP binding site [chemical binding]; other site 272634000401 Mg2+ binding site [ion binding]; other site 272634000402 G-X-G motif; other site 272634000403 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 272634000404 anchoring element; other site 272634000405 dimer interface [polypeptide binding]; other site 272634000406 ATP binding site [chemical binding]; other site 272634000407 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 272634000408 active site 272634000409 metal binding site [ion binding]; metal-binding site 272634000410 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 272634000411 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 272634000412 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 272634000413 CAP-like domain; other site 272634000414 active site 272634000415 primary dimer interface [polypeptide binding]; other site 272634000416 Transcriptional regulator of heat shock gene [Transcription]; Region: HrcA; COG1420 272634000417 HrcA protein C terminal domain; Region: HrcA; pfam01628 272634000418 excinuclease ABC, C subunit; Region: uvrC; TIGR00194 272634000419 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 272634000420 GIY-YIG motif/motif A; other site 272634000421 active site 272634000422 catalytic site [active] 272634000423 putative DNA binding site [nucleotide binding]; other site 272634000424 metal binding site [ion binding]; metal-binding site 272634000425 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 272634000426 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 272634000427 active site 272634000428 metal binding site [ion binding]; metal-binding site 272634000429 homotetramer interface [polypeptide binding]; other site 272634000430 Protein of unknown function DUF16; Region: DUF16; pfam01519 272634000431 Mycoplasma adhesin P1; Region: Adhesin_P1; pfam03257 272634000432 adhesin P1; Region: termin_org_P1; TIGR03839 272634000433 Micrococcal nuclease (thermonuclease) homologs [DNA replication, recombination, and repair]; Region: COG1525 272634000434 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 272634000435 Catalytic site; other site 272634000436 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272634000437 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 272634000438 Walker A/P-loop; other site 272634000439 ATP binding site [chemical binding]; other site 272634000440 Q-loop/lid; other site 272634000441 ABC transporter signature motif; other site 272634000442 Walker B; other site 272634000443 D-loop; other site 272634000444 H-loop/switch region; other site 272634000445 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 272634000446 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272634000447 dimer interface [polypeptide binding]; other site 272634000448 conserved gate region; other site 272634000449 putative PBP binding loops; other site 272634000450 ABC-ATPase subunit interface; other site 272634000451 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 272634000452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272634000453 dimer interface [polypeptide binding]; other site 272634000454 conserved gate region; other site 272634000455 putative PBP binding loops; other site 272634000456 ABC-ATPase subunit interface; other site 272634000457 Protein of unknown function DUF16; Region: DUF16; pfam01519 272634000458 Protein of unknown function DUF16; Region: DUF16; pfam01519 272634000459 Protein of unknown function DUF16; Region: DUF16; pfam01519 272634000460 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 272634000461 DHH family; Region: DHH; pfam01368 272634000462 DHHA1 domain; Region: DHHA1; pfam02272 272634000463 adhesin P1; Region: termin_org_P1; TIGR03839 272634000464 Trypsin-sensitive surface-exposed protein; Region: CytadhesinP1; pfam12378 272634000465 Trypsin-sensitive surface-exposed protein; Region: CytadhesinP1; pfam12378 272634000466 Mycoplasma adhesin P1; Region: Adhesin_P1; pfam03257 272634000467 MgpC protein precursor; Region: MgpC; pfam05220 272634000468 Mycoplasma adhesin P1; Region: Adhesin_P1; pfam03257 272634000469 Protein of unknown function DUF16; Region: DUF16; pfam01519 272634000470 Lipoprotein; Region: Lipoprotein_3; pfam00938 272634000471 MgpC protein precursor; Region: MgpC; pfam05220 272634000472 Protein of unknown function DUF16; Region: DUF16; pfam01519 272634000473 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 272634000474 Mycoplasma MG185/MG260 protein; Region: Lipoprotein_X; pfam03305 272634000475 Putative mycoplasma lipoprotein, C-terminal region; Region: Lipoprotein_10; pfam03202 272634000476 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 272634000477 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 272634000478 Part of AAA domain; Region: AAA_19; pfam13245 272634000479 AAA domain; Region: AAA_12; pfam13087 272634000480 transcription termination factor NusA; Region: NusA; TIGR01953 272634000481 NusA N-terminal domain; Region: NusA_N; pfam08529 272634000482 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272634000483 RNA binding site [nucleotide binding]; other site 272634000484 NusA-like KH domain; Region: KH_5; pfam13184 272634000485 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 272634000486 G-X-X-G motif; other site 272634000487 translation initiation factor IF-2; Region: IF-2; TIGR00487 272634000488 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 272634000489 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 272634000490 G1 box; other site 272634000491 putative GEF interaction site [polypeptide binding]; other site 272634000492 GTP/Mg2+ binding site [chemical binding]; other site 272634000493 Switch I region; other site 272634000494 G2 box; other site 272634000495 G3 box; other site 272634000496 Switch II region; other site 272634000497 G4 box; other site 272634000498 G5 box; other site 272634000499 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 272634000500 Translation-initiation factor 2; Region: IF-2; pfam11987 272634000501 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 272634000502 ribosome-binding factor A; Region: rbfA; TIGR00082 272634000503 large tegument protein UL36; Provisional; Region: PHA03247 272634000504 riboflavin kinase/FMN adenylyltransferase; Region: ribF; TIGR00083 272634000505 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 272634000506 active site 272634000507 Riboflavin kinase; Region: Flavokinase; pfam01687 272634000508 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 272634000509 Domain of unknown function DUF21; Region: DUF21; pfam01595 272634000510 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 272634000511 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 272634000512 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 272634000513 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 272634000514 ribosomal protein S10, bacterial/organelle; Region: rpsJ_bact; TIGR01049 272634000515 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 272634000516 50S ribosomal protein L4, bacterial/organelle; Region: rplD_bact; TIGR03953 272634000517 50S ribosomal protein L23; Reviewed; Region: rplW; PRK12280 272634000518 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 272634000519 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 272634000520 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 272634000521 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 272634000522 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 272634000523 putative translocon binding site; other site 272634000524 protein-rRNA interface [nucleotide binding]; other site 272634000525 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 272634000526 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 272634000527 G-X-X-G motif; other site 272634000528 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 272634000529 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 272634000530 23S rRNA interface [nucleotide binding]; other site 272634000531 5S rRNA interface [nucleotide binding]; other site 272634000532 putative antibiotic binding site [chemical binding]; other site 272634000533 L25 interface [polypeptide binding]; other site 272634000534 L27 interface [polypeptide binding]; other site 272634000535 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 272634000536 23S rRNA interface [nucleotide binding]; other site 272634000537 putative translocon interaction site; other site 272634000538 signal recognition particle (SRP54) interaction site; other site 272634000539 L23 interface [polypeptide binding]; other site 272634000540 trigger factor interaction site; other site 272634000541 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 272634000542 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 272634000543 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 272634000544 RNA binding site [nucleotide binding]; other site 272634000545 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 272634000546 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 272634000547 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 272634000548 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 272634000549 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 272634000550 ribosomal protein L6, bacterial type; Region: L6_bact; TIGR03654 272634000551 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 272634000552 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 272634000553 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 272634000554 5S rRNA interface [nucleotide binding]; other site 272634000555 L5 interface [polypeptide binding]; other site 272634000556 ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021 272634000557 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 272634000558 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 272634000559 ribosomal protein L15, bacterial/organelle; Region: rplO_bact; TIGR01071 272634000560 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 272634000561 SecY translocase; Region: SecY; pfam00344 272634000562 adenylate kinase; Region: adk; TIGR01351 272634000563 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 272634000564 AMP-binding site [chemical binding]; other site 272634000565 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 272634000566 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 272634000567 active site 272634000568 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 272634000569 rRNA binding site [nucleotide binding]; other site 272634000570 predicted 30S ribosome binding site; other site 272634000571 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 272634000572 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 272634000573 30S ribosomal protein S11; Validated; Region: PRK05309 272634000574 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 272634000575 alphaNTD homodimer interface [polypeptide binding]; other site 272634000576 DNA-directed RNA polymerase, alpha subunit, bacterial and chloroplast-type; Region: rpoA; TIGR02027 272634000577 alphaNTD - beta interaction site [polypeptide binding]; other site 272634000578 alphaNTD - beta' interaction site [polypeptide binding]; other site 272634000579 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 272634000580 ribosomal protein L17; Region: L17; TIGR00059 272634000581 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13632 272634000582 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 272634000583 Walker A/P-loop; other site 272634000584 ATP binding site [chemical binding]; other site 272634000585 Q-loop/lid; other site 272634000586 ABC transporter signature motif; other site 272634000587 Walker B; other site 272634000588 D-loop; other site 272634000589 H-loop/switch region; other site 272634000590 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13631 272634000591 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 272634000592 Walker A/P-loop; other site 272634000593 ATP binding site [chemical binding]; other site 272634000594 Q-loop/lid; other site 272634000595 ABC transporter signature motif; other site 272634000596 Walker B; other site 272634000597 D-loop; other site 272634000598 H-loop/switch region; other site 272634000599 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 272634000600 tRNA pseudouridine(38-40) synthase; Region: hisT_truA; TIGR00071 272634000601 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 272634000602 dimerization interface 3.5A [polypeptide binding]; other site 272634000603 active site 272634000604 oligoendopeptidase F; Region: pepF; TIGR00181 272634000605 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 272634000606 active site 272634000607 Zn binding site [ion binding]; other site 272634000608 Adenine-specific methyltransferase EcoRI; Region: EcoRI_methylase; pfam13651 272634000609 Mycoplasma MG185/MG260 protein; Region: Lipoprotein_X; pfam03305 272634000610 Putative mycoplasma lipoprotein, C-terminal region; Region: Lipoprotein_10; pfam03202 272634000611 Mycoplasma MG185/MG260 protein; Region: Lipoprotein_X; pfam03305 272634000612 Putative mycoplasma lipoprotein, C-terminal region; Region: Lipoprotein_10; pfam03202 272634000613 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 272634000614 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272634000615 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272634000616 Mycoplasma adhesin P1; Region: Adhesin_P1; pfam03257 272634000617 Protein of unknown function DUF16; Region: DUF16; pfam01519 272634000618 Trypsin-sensitive surface-exposed protein; Region: CytadhesinP1; pfam12378 272634000619 Trypsin-sensitive surface-exposed protein; Region: CytadhesinP1; pfam12378 272634000620 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 272634000621 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 272634000622 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272634000623 active site turn [active] 272634000624 phosphorylation site [posttranslational modification] 272634000625 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 272634000626 HPr interaction site; other site 272634000627 glycerol kinase (GK) interaction site [polypeptide binding]; other site 272634000628 active site 272634000629 phosphorylation site [posttranslational modification] 272634000630 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 272634000631 rRNA interaction site [nucleotide binding]; other site 272634000632 S8 interaction site; other site 272634000633 putative laminin-1 binding site; other site 272634000634 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 272634000635 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 272634000636 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 272634000637 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 272634000638 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 272634000639 Soluble P-type ATPase [General function prediction only]; Region: COG4087 272634000640 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 272634000641 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12903 272634000642 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 272634000643 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272634000644 nucleotide binding region [chemical binding]; other site 272634000645 ATP-binding site [chemical binding]; other site 272634000646 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 272634000647 excinuclease ABC, B subunit; Region: uvrb; TIGR00631 272634000648 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 272634000649 ATP binding site [chemical binding]; other site 272634000650 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272634000651 nucleotide binding region [chemical binding]; other site 272634000652 ATP-binding site [chemical binding]; other site 272634000653 Ultra-violet resistance protein B; Region: UvrB; pfam12344 272634000654 UvrB/uvrC motif; Region: UVR; pfam02151 272634000655 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 272634000656 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272634000657 dimer interface [polypeptide binding]; other site 272634000658 conserved gate region; other site 272634000659 putative PBP binding loops; other site 272634000660 ABC-ATPase subunit interface; other site 272634000661 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 272634000662 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272634000663 dimer interface [polypeptide binding]; other site 272634000664 conserved gate region; other site 272634000665 putative PBP binding loops; other site 272634000666 ABC-ATPase subunit interface; other site 272634000667 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 272634000668 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 272634000669 Walker A/P-loop; other site 272634000670 ATP binding site [chemical binding]; other site 272634000671 Q-loop/lid; other site 272634000672 ABC transporter signature motif; other site 272634000673 Walker B; other site 272634000674 D-loop; other site 272634000675 H-loop/switch region; other site 272634000676 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272634000677 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272634000678 Walker A/P-loop; other site 272634000679 ATP binding site [chemical binding]; other site 272634000680 Q-loop/lid; other site 272634000681 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 272634000682 ectoine/hydroxyectoine ABC transporter, ATP-binding protein; Region: ectoine_ehuA; TIGR03005 272634000683 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272634000684 ABC transporter signature motif; other site 272634000685 Walker B; other site 272634000686 D-loop; other site 272634000687 H-loop/switch region; other site 272634000688 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 272634000689 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 272634000690 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 272634000691 23S rRNA interface [nucleotide binding]; other site 272634000692 L7/L12 interface [polypeptide binding]; other site 272634000693 putative thiostrepton binding site; other site 272634000694 L25 interface [polypeptide binding]; other site 272634000695 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 272634000696 mRNA/rRNA interface [nucleotide binding]; other site 272634000697 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 272634000698 putative active site [active] 272634000699 catalytic residue [active] 272634000700 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 272634000701 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 272634000702 Ligand Binding Site [chemical binding]; other site 272634000703 Serine kinase of the HPr protein, regulates carbohydrate metabolism [Signal transduction mechanisms]; Region: HprK; COG1493 272634000704 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 272634000705 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 272634000706 Hpr binding site; other site 272634000707 active site 272634000708 homohexamer subunit interaction site [polypeptide binding]; other site 272634000709 prolipoprotein diacylglyceryl transferase; Region: lgt; TIGR00544 272634000710 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 272634000711 16S rRNA interaction site [nucleotide binding]; other site 272634000712 streptomycin interaction site [chemical binding]; other site 272634000713 23S rRNA interaction site [nucleotide binding]; other site 272634000714 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 272634000715 30S ribosomal protein S7; Validated; Region: PRK05302 272634000716 elongation factor G; Reviewed; Region: PRK12739 272634000717 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 272634000718 G1 box; other site 272634000719 putative GEF interaction site [polypeptide binding]; other site 272634000720 GTP/Mg2+ binding site [chemical binding]; other site 272634000721 Switch I region; other site 272634000722 G2 box; other site 272634000723 G3 box; other site 272634000724 Switch II region; other site 272634000725 G4 box; other site 272634000726 G5 box; other site 272634000727 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 272634000728 Elongation Factor G, domain II; Region: EFG_II; pfam14492 272634000729 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 272634000730 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 272634000731 ribosomal protein S6; Region: S6; TIGR00166 272634000732 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 272634000733 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 272634000734 dimer interface [polypeptide binding]; other site 272634000735 ssDNA binding site [nucleotide binding]; other site 272634000736 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272634000737 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 272634000738 ribosomal protein L9; Region: L9; TIGR00158 272634000739 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 272634000740 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 272634000741 Replicative DNA helicase [DNA replication, recombination, and repair]; Region: DnaB; COG0305 272634000742 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 272634000743 Walker A motif; other site 272634000744 ATP binding site [chemical binding]; other site 272634000745 Walker B motif; other site 272634000746 DNA binding loops [nucleotide binding] 272634000747 MG032/MG096/MG288 family 2; Region: DUF240; pfam03086 272634000748 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 272634000749 MG032/MG096/MG288 family 1; Region: DUF237; pfam03072 272634000750 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 272634000751 ligand binding site [chemical binding]; other site 272634000752 active site 272634000753 UGI interface [polypeptide binding]; other site 272634000754 catalytic site [active] 272634000755 aspartyl/glutamyl-tRNA amidotransferase subunit C-like protein; Provisional; Region: PRK12821 272634000756 hypothetical protein; Provisional; Region: PRK09609 272634000757 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit [Translation, ribosomal structure and biogenesis]; Region: GatC; COG0721 272634000758 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, A subunit; Region: gatA; TIGR00132 272634000759 aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, B subunit; Region: gatB; TIGR00133 272634000760 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 272634000761 GatB domain; Region: GatB_Yqey; pfam02637 272634000762 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 272634000763 DNA-binding site [nucleotide binding]; DNA binding site 272634000764 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 272634000765 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272634000766 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272634000767 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272634000768 conserved hypothetical protein; Region: MG103; TIGR00647 272634000769 LAGLIDADG-like domain; Region: LAGLIDADG_3; cl08299 272634000770 WhiA C-terminal HTH domain; Region: HTH_WhiA; pfam02650 272634000771 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 272634000772 VacB and RNase II family 3'-5' exoribonucleases; Region: 3_prime_RNase; TIGR00358 272634000773 Cold shock protein domain; Region: CSP; smart00357 272634000774 RNB domain; Region: RNB; pfam00773 272634000775 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 272634000776 RNA binding site [nucleotide binding]; other site 272634000777 TIGR00159 family protein; Region: TIGR00159 272634000778 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 272634000779 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 272634000780 active site 272634000781 catalytic residues [active] 272634000782 metal binding site [ion binding]; metal-binding site 272634000783 Guanylate kinase; Region: Guanylate_kin; pfam00625 272634000784 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 272634000785 catalytic site [active] 272634000786 G-X2-G-X-G-K; other site 272634000787 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 272634000788 active site 272634000789 Catalytic domain of Protein Kinases; Region: PKc; cd00180 272634000790 active site 272634000791 ATP binding site [chemical binding]; other site 272634000792 substrate binding site [chemical binding]; other site 272634000793 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 272634000794 activation loop (A-loop); other site 272634000795 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 272634000796 RNA binding site [nucleotide binding]; other site 272634000797 ribosome small subunit-dependent GTPase A; Region: TIGR00157 272634000798 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 272634000799 GTPase/Zn-binding domain interface [polypeptide binding]; other site 272634000800 GTP/Mg2+ binding site [chemical binding]; other site 272634000801 G4 box; other site 272634000802 G5 box; other site 272634000803 G1 box; other site 272634000804 Switch I region; other site 272634000805 G2 box; other site 272634000806 G3 box; other site 272634000807 Switch II region; other site 272634000808 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 272634000809 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 272634000810 active site 272634000811 dimer interface [polypeptide binding]; other site 272634000812 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 272634000813 dimer interface [polypeptide binding]; other site 272634000814 active site 272634000815 Ribulose-phosphate 3 epimerase family; Region: Ribul_P_3_epim; pfam00834 272634000816 phosphate binding site [ion binding]; other site 272634000817 asparaginyl-tRNA synthetase; Region: asnS; TIGR00457 272634000818 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 272634000819 putative dimer interface [polypeptide binding]; other site 272634000820 putative anticodon binding site; other site 272634000821 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 272634000822 motif 1; other site 272634000823 dimer interface [polypeptide binding]; other site 272634000824 active site 272634000825 motif 2; other site 272634000826 motif 3; other site 272634000827 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 272634000828 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 272634000829 4-diphosphocytidyl-2-methyl-D-erithritol synthase [Lipid metabolism]; Region: IspD; COG1211 272634000830 active site 272634000831 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 272634000832 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 272634000833 NAD binding site [chemical binding]; other site 272634000834 homodimer interface [polypeptide binding]; other site 272634000835 active site 272634000836 substrate binding site [chemical binding]; other site 272634000837 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 272634000838 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 272634000839 Walker A/P-loop; other site 272634000840 ATP binding site [chemical binding]; other site 272634000841 Q-loop/lid; other site 272634000842 ABC transporter signature motif; other site 272634000843 Walker B; other site 272634000844 D-loop; other site 272634000845 H-loop/switch region; other site 272634000846 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 272634000847 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 272634000848 TM-ABC transporter signature motif; other site 272634000849 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 272634000850 TM-ABC transporter signature motif; other site 272634000851 DNA topoisomerase I; Validated; Region: PRK05582 272634000852 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 272634000853 active site 272634000854 interdomain interaction site; other site 272634000855 putative metal-binding site [ion binding]; other site 272634000856 nucleotide binding site [chemical binding]; other site 272634000857 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 272634000858 domain I; other site 272634000859 DNA binding groove [nucleotide binding] 272634000860 phosphate binding site [ion binding]; other site 272634000861 domain II; other site 272634000862 domain III; other site 272634000863 nucleotide binding site [chemical binding]; other site 272634000864 catalytic site [active] 272634000865 domain IV; other site 272634000866 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 272634000867 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 272634000868 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 272634000869 catalytic residues [active] 272634000870 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 272634000871 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272634000872 tryptophanyl-tRNA synthetase; Reviewed; Region: PRK00927 272634000873 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 272634000874 active site 272634000875 HIGH motif; other site 272634000876 dimer interface [polypeptide binding]; other site 272634000877 KMSKS motif; other site 272634000878 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 272634000879 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK00561 272634000880 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 272634000881 active site turn [active] 272634000882 phosphorylation site [posttranslational modification] 272634000883 hypothetical protein; Provisional; Region: PRK12705 272634000884 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272634000885 Zn2+ binding site [ion binding]; other site 272634000886 Mg2+ binding site [ion binding]; other site 272634000887 Lipoprotein; Region: Lipoprotein_3; pfam00938 272634000888 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 272634000889 HIT family signature motif; other site 272634000890 catalytic residue [active] 272634000891 Protein of unknown function (DUF1600); Region: DUF1600; pfam07667 272634000892 DNA-binding protein, YbaB/EbfC family; Region: DNA_YbaB_EbfC; TIGR00103 272634000893 lysyl-tRNA synthetase, eukaryotic and non-spirochete bacterial; Region: lysS_bact; TIGR00499 272634000894 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 272634000895 dimer interface [polypeptide binding]; other site 272634000896 putative anticodon binding site; other site 272634000897 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 272634000898 motif 1; other site 272634000899 active site 272634000900 motif 2; other site 272634000901 motif 3; other site 272634000902 UDP-galactopyranose mutase; Region: UDP-GALP_mutase; TIGR00031 272634000903 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 272634000904 UDP-galactopyranose mutase; Region: GLF; pfam03275 272634000905 GTP-binding protein LepA; Provisional; Region: PRK05433 272634000906 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 272634000907 G1 box; other site 272634000908 putative GEF interaction site [polypeptide binding]; other site 272634000909 GTP/Mg2+ binding site [chemical binding]; other site 272634000910 Switch I region; other site 272634000911 G2 box; other site 272634000912 G3 box; other site 272634000913 Switch II region; other site 272634000914 G4 box; other site 272634000915 G5 box; other site 272634000916 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 272634000917 Elongation Factor G, domain II; Region: EFG_II; pfam14492 272634000918 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 272634000919 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 272634000920 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 272634000921 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 272634000922 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 272634000923 Protein of unknown function DUF16; Region: DUF16; pfam01519 272634000924 Mycoplasma MG185/MG260 protein; Region: Lipoprotein_X; pfam03305 272634000925 Putative mycoplasma lipoprotein, C-terminal region; Region: Lipoprotein_10; pfam03202 272634000926 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 272634000927 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272634000928 MgtE intracellular N domain; Region: MgtE_N; cl15244 272634000929 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272634000930 Mycoplasma adhesin P1; Region: Adhesin_P1; pfam03257 272634000931 Protein of unknown function DUF16; Region: DUF16; pfam01519 272634000932 Mycoplasma MG185/MG260 protein; Region: Lipoprotein_X; pfam03305 272634000933 Putative mycoplasma lipoprotein, C-terminal region; Region: Lipoprotein_10; pfam03202 272634000934 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 272634000935 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272634000936 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 272634000937 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272634000938 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 272634000939 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 272634000940 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272634000941 RNA binding surface [nucleotide binding]; other site 272634000942 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 272634000943 active site 272634000944 signal peptidase II; Provisional; Region: lspA; PRK00573 272634000945 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 272634000946 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 272634000947 conserved cys residue [active] 272634000948 DNA gyrase subunit b; Provisional; Region: PTZ00109 272634000949 Ribosomal protein S21 [Translation, ribosomal structure and biogenesis]; Region: RpsU; COG0828 272634000950 DivIVA domain; Region: DivI1A_domain; TIGR03544 272634000951 Phosphopantetheinyl transferase (holo-ACP synthase) [Lipid metabolism]; Region: AcpS; COG0736 272634000952 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 272634000953 putative acyl-acceptor binding pocket; other site 272634000954 segregation and condensation protein A/unknown domain fusion protein; Provisional; Region: scpA; PRK00478 272634000955 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 272634000956 folate binding site [chemical binding]; other site 272634000957 NADP+ binding site [chemical binding]; other site 272634000958 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 272634000959 segregation and condensation protein B; Region: TIGR00281 272634000960 6-phosphofructokinase; Provisional; Region: PRK03202 272634000961 active site 272634000962 ADP/pyrophosphate binding site [chemical binding]; other site 272634000963 dimerization interface [polypeptide binding]; other site 272634000964 allosteric effector site; other site 272634000965 fructose-1,6-bisphosphate binding site; other site 272634000966 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 272634000967 pyruvate kinase; Region: pyruv_kin; TIGR01064 272634000968 domain interfaces; other site 272634000969 active site 272634000970 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 272634000971 putative substrate binding site [chemical binding]; other site 272634000972 nucleotide binding site [chemical binding]; other site 272634000973 nucleotide binding site [chemical binding]; other site 272634000974 homodimer interface [polypeptide binding]; other site 272634000975 Amino acid permease; Region: AA_permease_2; pfam13520 272634000976 DNA translocase FtsK; Provisional; Region: PRK10263 272634000977 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 272634000978 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 272634000979 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 272634000980 ribonuclease E; Reviewed; Region: rne; PRK10811 272634000981 mraZ protein; Region: TIGR00242 272634000982 MraZ protein; Region: MraZ; pfam02381 272634000983 MraZ protein; Region: MraZ; pfam02381 272634000984 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 272634000985 cell division protein FtsZ; Region: ftsZ; TIGR00065 272634000986 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 272634000987 nucleotide binding site [chemical binding]; other site 272634000988 SulA interaction site; other site 272634000989 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 272634000990 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 272634000991 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 272634000992 dimerization interface [polypeptide binding]; other site 272634000993 active site 272634000994 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 272634000995 folate binding site [chemical binding]; other site 272634000996 NADP+ binding site [chemical binding]; other site 272634000997 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 272634000998 dimer interface [polypeptide binding]; other site 272634000999 putative radical transfer pathway; other site 272634001000 diiron center [ion binding]; other site 272634001001 tyrosyl radical; other site 272634001002 ribonucleoside-diphosphate reductase 2, operon protein nrdI; Region: nrdI; TIGR00333 272634001003 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07187 272634001004 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 272634001005 Class I ribonucleotide reductase; Region: RNR_I; cd01679 272634001006 active site 272634001007 dimer interface [polypeptide binding]; other site 272634001008 catalytic residues [active] 272634001009 effector binding site; other site 272634001010 R2 peptide binding site; other site 272634001011 ribosomal protein L21; Region: L21; TIGR00061 272634001012 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 272634001013 Ribosomal protein L27 [Translation, ribosomal structure and biogenesis]; Region: RpmA; COG0211 272634001014 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 272634001015 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 272634001016 AP (apurinic/apyrimidinic) site pocket; other site 272634001017 DNA interaction; other site 272634001018 Metal-binding active site; metal-binding site 272634001019 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 272634001020 metal binding site 2 [ion binding]; metal-binding site 272634001021 putative DNA binding helix; other site 272634001022 metal binding site 1 [ion binding]; metal-binding site 272634001023 Protein of unknown function (DUF3196); Region: DUF3196; pfam11428 272634001024 FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones]; Region: Tig; COG0544 272634001025 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 272634001026 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 272634001027 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 272634001028 ATP-dependent protease La; Region: lon; TIGR00763 272634001029 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 272634001030 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272634001031 Walker A motif; other site 272634001032 ATP binding site [chemical binding]; other site 272634001033 Walker B motif; other site 272634001034 arginine finger; other site 272634001035 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 272634001036 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 272634001037 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 272634001038 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 272634001039 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 272634001040 Walker A/P-loop; other site 272634001041 ATP binding site [chemical binding]; other site 272634001042 Q-loop/lid; other site 272634001043 ABC transporter signature motif; other site 272634001044 Walker B; other site 272634001045 D-loop; other site 272634001046 H-loop/switch region; other site 272634001047 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 272634001048 putative nicotinate-nucleotide adenylyltransferase; Validated; Region: nadD; PRK07152 272634001049 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 272634001050 active site 272634001051 (T/H)XGH motif; other site 272634001052 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272634001053 Zn2+ binding site [ion binding]; other site 272634001054 Mg2+ binding site [ion binding]; other site 272634001055 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 272634001056 RDD family; Region: RDD; pfam06271 272634001057 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 272634001058 Part of AAA domain; Region: AAA_19; pfam13245 272634001059 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 272634001060 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 272634001061 Part of AAA domain; Region: AAA_19; pfam13245 272634001062 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 272634001063 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 272634001064 HsdM N-terminal domain; Region: HsdM_N; pfam12161 272634001065 Methyltransferase domain; Region: Methyltransf_26; pfam13659 272634001066 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 272634001067 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272634001068 MgtE intracellular N domain; Region: MgtE_N; cl15244 272634001069 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272634001070 Protein of unknown function DUF16; Region: DUF16; pfam01519 272634001071 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 272634001072 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 272634001073 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 272634001074 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 272634001075 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 272634001076 putative active site [active] 272634001077 metal binding site [ion binding]; metal-binding site 272634001078 homodimer binding site [polypeptide binding]; other site 272634001079 acyl-phosphate glycerol 3-phosphate acyltransferase; Region: TIGR00023 272634001080 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 272634001081 RNA polymerase sigma factor; Provisional; Region: PRK05901 272634001082 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 272634001083 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 272634001084 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 272634001085 DNA binding residues [nucleotide binding] 272634001086 DNA primase, catalytic core; Region: dnaG; TIGR01391 272634001087 CHC2 zinc finger; Region: zf-CHC2; pfam01807 272634001088 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 272634001089 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 272634001090 active site 272634001091 metal binding site [ion binding]; metal-binding site 272634001092 interdomain interaction site; other site 272634001093 glycyl-tRNA synthetase, dimeric type; Region: glyS_dimeric; TIGR00389 272634001094 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 272634001095 dimer interface [polypeptide binding]; other site 272634001096 motif 1; other site 272634001097 active site 272634001098 motif 2; other site 272634001099 motif 3; other site 272634001100 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 272634001101 anticodon binding site; other site 272634001102 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 272634001103 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 272634001104 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 272634001105 cysteinyl-tRNA synthetase; Region: cysS; TIGR00435 272634001106 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 272634001107 active site 272634001108 HIGH motif; other site 272634001109 KMSKS motif; other site 272634001110 This DALR domain is found in cysteinyl-tRNA-synthetases; Region: DALR_2; smart00840 272634001111 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 272634001112 DNA ligase, NAD-dependent; Region: dnlj; TIGR00575 272634001113 nucleotide binding pocket [chemical binding]; other site 272634001114 K-X-D-G motif; other site 272634001115 catalytic site [active] 272634001116 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 272634001117 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 272634001118 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 272634001119 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 272634001120 Dimer interface [polypeptide binding]; other site 272634001121 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 272634001122 peptide chain release factor 1; Region: prfA; TIGR00019 272634001123 PCRF domain; Region: PCRF; pfam03462 272634001124 RF-1 domain; Region: RF-1; pfam00472 272634001125 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 272634001126 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272634001127 S-adenosylmethionine binding site [chemical binding]; other site 272634001128 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 272634001129 Mycoplasma MG185/MG260 protein; Region: Lipoprotein_X; pfam03305 272634001130 Putative mycoplasma lipoprotein, C-terminal region; Region: Lipoprotein_10; pfam03202 272634001131 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 272634001132 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272634001133 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272634001134 Protein of unknown function DUF16; Region: DUF16; pfam01519 272634001135 Lipoprotein; Region: Lipoprotein_3; pfam00938 272634001136 Mycoplasma adhesin P1; Region: Adhesin_P1; pfam03257 272634001137 Pertussis toxin, subunit 1; Region: Pertussis_S1; pfam02917 272634001138 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 272634001139 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 272634001140 active site 272634001141 PHP Thumb interface [polypeptide binding]; other site 272634001142 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 272634001143 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 272634001144 5'-3' exonuclease; Provisional; Region: PRK14976 272634001145 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 272634001146 active site 272634001147 metal binding site 1 [ion binding]; metal-binding site 272634001148 putative 5' ssDNA interaction site; other site 272634001149 metal binding site 3; metal-binding site 272634001150 metal binding site 2 [ion binding]; metal-binding site 272634001151 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 272634001152 putative DNA binding site [nucleotide binding]; other site 272634001153 putative metal binding site [ion binding]; other site 272634001154 formamidopyrimidine-DNA glycosylase (fpg); Region: fpg; TIGR00577 272634001155 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 272634001156 DNA binding site [nucleotide binding] 272634001157 catalytic residue [active] 272634001158 H2TH interface [polypeptide binding]; other site 272634001159 putative catalytic residues [active] 272634001160 turnover-facilitating residue; other site 272634001161 intercalation triad [nucleotide binding]; other site 272634001162 8OG recognition residue [nucleotide binding]; other site 272634001163 putative reading head residues; other site 272634001164 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 272634001165 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 272634001166 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 272634001167 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272634001168 active site 272634001169 motif I; other site 272634001170 motif II; other site 272634001171 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272634001172 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 272634001173 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 272634001174 CoA-binding site [chemical binding]; other site 272634001175 ATP-binding [chemical binding]; other site 272634001176 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 272634001177 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272634001178 active site 272634001179 motif I; other site 272634001180 motif II; other site 272634001181 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272634001182 leucyl-tRNA synthetase, eubacterial and mitochondrial family; Region: leuS_bact; TIGR00396 272634001183 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 272634001184 active site 272634001185 HIGH motif; other site 272634001186 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 272634001187 KMSKS motif; other site 272634001188 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 272634001189 tRNA binding surface [nucleotide binding]; other site 272634001190 anticodon binding site; other site 272634001191 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 272634001192 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 272634001193 Substrate-binding site [chemical binding]; other site 272634001194 Substrate specificity [chemical binding]; other site 272634001195 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 272634001196 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 272634001197 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 272634001198 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 272634001199 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 272634001200 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 272634001201 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272634001202 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 272634001203 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 272634001204 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 272634001205 E3 interaction surface; other site 272634001206 lipoyl attachment site [posttranslational modification]; other site 272634001207 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 272634001208 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 272634001209 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 272634001210 alpha subunit interface [polypeptide binding]; other site 272634001211 TPP binding site [chemical binding]; other site 272634001212 heterodimer interface [polypeptide binding]; other site 272634001213 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 272634001214 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 272634001215 tetramer interface [polypeptide binding]; other site 272634001216 TPP-binding site [chemical binding]; other site 272634001217 heterodimer interface [polypeptide binding]; other site 272634001218 phosphorylation loop region [posttranslational modification] 272634001219 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 272634001220 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 272634001221 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 272634001222 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272634001223 active site 272634001224 bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024 272634001225 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 272634001226 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272634001227 Zn2+ binding site [ion binding]; other site 272634001228 Mg2+ binding site [ion binding]; other site 272634001229 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 272634001230 synthetase active site [active] 272634001231 NTP binding site [chemical binding]; other site 272634001232 metal binding site [ion binding]; metal-binding site 272634001233 Protein of unknown function (DUF342); Region: DUF342; cl19219 272634001234 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 272634001235 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 272634001236 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 272634001237 prolyl-tRNA synthetase, family I; Region: proS_fam_I; TIGR00408 272634001238 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 272634001239 motif 1; other site 272634001240 dimer interface [polypeptide binding]; other site 272634001241 active site 272634001242 motif 2; other site 272634001243 motif 3; other site 272634001244 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 272634001245 anticodon binding site; other site 272634001246 Prolyl-tRNA synthetase, C-terminal; Region: ProRS-C_1; smart00946 272634001247 acyl carrier protein; Validated; Region: PRK05828 272634001248 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 272634001249 active site 272634001250 oxyanion hole [active] 272634001251 Stringent starvation protein B; Region: SspB; cl01120 272634001252 Mycoplasma MG185/MG260 protein; Region: Lipoprotein_X; pfam03305 272634001253 Putative mycoplasma lipoprotein, C-terminal region; Region: Lipoprotein_10; pfam03202 272634001254 Mycoplasma adhesin P1; Region: Adhesin_P1; pfam03257 272634001255 Protein of unknown function DUF16; Region: DUF16; pfam01519 272634001256 Lipoprotein; Region: Lipoprotein_3; pfam00938 272634001257 Trypsin-sensitive surface-exposed protein; Region: CytadhesinP1; pfam12378 272634001258 MgpC protein precursor; Region: MgpC; pfam05220 272634001259 High affinity transport system protein p37; Region: Mycoplasma_p37; pfam06646 272634001260 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 272634001261 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272634001262 Walker A/P-loop; other site 272634001263 ATP binding site [chemical binding]; other site 272634001264 Q-loop/lid; other site 272634001265 ABC transporter signature motif; other site 272634001266 Walker B; other site 272634001267 D-loop; other site 272634001268 H-loop/switch region; other site 272634001269 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 272634001270 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 272634001271 Predicted endonuclease involved in recombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis) [DNA replication, recombination, and repair]; Region: COG0816 272634001272 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 272634001273 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 272634001274 alanine--tRNA ligase; Region: alaS; TIGR00344 272634001275 motif 1; other site 272634001276 active site 272634001277 motif 2; other site 272634001278 motif 3; other site 272634001279 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 272634001280 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 272634001281 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 272634001282 active site 272634001283 catalytic site [active] 272634001284 Major Facilitator Superfamily; Region: MFS_1; pfam07690 272634001285 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 272634001286 putative substrate translocation pore; other site 272634001287 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 272634001288 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 272634001289 Ligand Binding Site [chemical binding]; other site 272634001290 Mg296 protein; Region: Mg296; pfam09644 272634001291 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 272634001292 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 272634001293 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 272634001294 SRP54-type protein, GTPase domain; Region: SRP54; pfam00448 272634001295 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 272634001296 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 272634001297 Walker A/P-loop; other site 272634001298 ATP binding site [chemical binding]; other site 272634001299 Q-loop/lid; other site 272634001300 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 272634001301 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 272634001302 ABC transporter signature motif; other site 272634001303 Walker B; other site 272634001304 D-loop; other site 272634001305 H-loop/switch region; other site 272634001306 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 272634001307 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 272634001308 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 272634001309 active site 272634001310 motif I; other site 272634001311 motif II; other site 272634001312 phosphate acetyltransferase; Region: pta; TIGR00651 272634001313 3-phosphoglycerate kinase [Carbohydrate transport and metabolism]; Region: Pgk; COG0126 272634001314 substrate binding site [chemical binding]; other site 272634001315 hinge regions; other site 272634001316 ADP binding site [chemical binding]; other site 272634001317 catalytic site [active] 272634001318 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 272634001319 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 272634001320 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 272634001321 Cobalt transport protein; Region: CbiQ; pfam02361 272634001322 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 272634001323 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 272634001324 Walker A/P-loop; other site 272634001325 ATP binding site [chemical binding]; other site 272634001326 Q-loop/lid; other site 272634001327 ABC transporter signature motif; other site 272634001328 Walker B; other site 272634001329 D-loop; other site 272634001330 H-loop/switch region; other site 272634001331 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 272634001332 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 272634001333 Walker A/P-loop; other site 272634001334 ATP binding site [chemical binding]; other site 272634001335 Q-loop/lid; other site 272634001336 ABC transporter signature motif; other site 272634001337 Walker B; other site 272634001338 D-loop; other site 272634001339 H-loop/switch region; other site 272634001340 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 272634001341 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 272634001342 nucleotide binding site [chemical binding]; other site 272634001343 Predicted integral membrane protein [Function unknown]; Region: COG0392 272634001344 Protein of unknown function (DUF3713); Region: DUF3713; pfam12506 272634001345 Protein of unknown function (DUF3713); Region: DUF3713; pfam12506 272634001346 DEAD/DEAH box helicase; Region: DEAD; pfam00270 272634001347 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 272634001348 ATP binding site [chemical binding]; other site 272634001349 putative Mg++ binding site [ion binding]; other site 272634001350 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272634001351 nucleotide binding region [chemical binding]; other site 272634001352 ATP-binding site [chemical binding]; other site 272634001353 Protein of unknown function (DUF3713); Region: DUF3713; pfam12506 272634001354 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272634001355 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272634001356 Serine hydrolase; Region: Ser_hydrolase; cl17834 272634001357 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 272634001358 ribosomal protein S4, bacterial/organelle type; Region: rpsD_bact; TIGR01017 272634001359 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272634001360 RNA binding surface [nucleotide binding]; other site 272634001361 cytadherence high molecular weight protein 1 N-terminal region; Region: termin_org_HMW1; TIGR03836 272634001362 EAGR box; Region: EAGR_box; TIGR03834 272634001363 Mitochondria Localisation Sequence; Region: AIF-MLS; pfam14962 272634001364 Multi-glycosylated core protein 24 (MGC-24); Region: MGC-24; pfam05283 272634001365 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 272634001366 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 272634001367 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; cl19912 272634001368 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 272634001369 ComEC/Rec2-related protein; Region: ComEC_N-term; TIGR00360 272634001370 DNA translocase FtsK; Provisional; Region: PRK10263 272634001371 ribonuclease E; Reviewed; Region: rne; PRK10811 272634001372 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 272634001373 Cytadhesin P30/P32; Region: Cytadhesin_P30; pfam07271 272634001374 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 272634001375 G-box binding protein MFMR; Region: MFMR; pfam07777 272634001376 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 272634001377 Cation transport protein; Region: TrkH; cl17365 272634001378 Cation transport protein; Region: TrkH; pfam02386 272634001379 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 272634001380 TrkA-N domain; Region: TrkA_N; pfam02254 272634001381 TrkA-C domain; Region: TrkA_C; pfam02080 272634001382 Trypsin-sensitive surface-exposed protein; Region: CytadhesinP1; pfam12378 272634001383 MgpC protein precursor; Region: MgpC; pfam05220 272634001384 Protein of unknown function DUF16; Region: DUF16; pfam01519 272634001385 Mycoplasma adhesin P1; Region: Adhesin_P1; pfam03257 272634001386 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 272634001387 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 272634001388 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 272634001389 active site 272634001390 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 272634001391 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 272634001392 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272634001393 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 272634001394 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 272634001395 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 272634001396 Protein of unknown function (DUF342); Region: DUF342; cl19219 272634001397 Predicted GTPases [General function prediction only]; Region: COG1160 272634001398 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 272634001399 G1 box; other site 272634001400 GTP/Mg2+ binding site [chemical binding]; other site 272634001401 Switch I region; other site 272634001402 G2 box; other site 272634001403 Switch II region; other site 272634001404 G3 box; other site 272634001405 G4 box; other site 272634001406 G5 box; other site 272634001407 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 272634001408 G1 box; other site 272634001409 GTP/Mg2+ binding site [chemical binding]; other site 272634001410 Switch I region; other site 272634001411 G2 box; other site 272634001412 G3 box; other site 272634001413 Switch II region; other site 272634001414 G4 box; other site 272634001415 G5 box; other site 272634001416 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 272634001417 cytidylate kinase; Region: cmk; TIGR00017 272634001418 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 272634001419 CMP-binding site; other site 272634001420 The sites determining sugar specificity; other site 272634001421 Uncharacterized conserved protein [Function unknown]; Region: COG0217 272634001422 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 272634001423 valyl-tRNA synthetase; Region: valS; TIGR00422 272634001424 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 272634001425 active site 272634001426 HIGH motif; other site 272634001427 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 272634001428 KMSKS motif; other site 272634001429 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 272634001430 tRNA binding surface [nucleotide binding]; other site 272634001431 anticodon binding site; other site 272634001432 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 272634001433 Predicted GTPase [General function prediction only]; Region: COG0218 272634001434 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 272634001435 G1 box; other site 272634001436 GTP/Mg2+ binding site [chemical binding]; other site 272634001437 Switch I region; other site 272634001438 G2 box; other site 272634001439 G3 box; other site 272634001440 Switch II region; other site 272634001441 G4 box; other site 272634001442 G5 box; other site 272634001443 hypothetical protein; Provisional; Region: PRK00523 272634001444 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 272634001445 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 272634001446 active site 272634001447 Protein of unknown function DUF16; Region: DUF16; pfam01519 272634001448 Aminotransferase class-V; Region: Aminotran_5; pfam00266 272634001449 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 272634001450 catalytic residue [active] 272634001451 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 272634001452 trimerization site [polypeptide binding]; other site 272634001453 active site 272634001454 Protein of unknown function (DUF3713); Region: DUF3713; pfam12506 272634001455 RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468 272634001456 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 272634001457 Walker A motif; other site 272634001458 ATP binding site [chemical binding]; other site 272634001459 Walker B motif; other site 272634001460 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 272634001461 putative catalytic site [active] 272634001462 putative metal binding site [ion binding]; other site 272634001463 putative phosphate binding site [ion binding]; other site 272634001464 hexulose-6-phosphate isomerase, putative; Region: hxl6Piso_put; TIGR00542 272634001465 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 272634001466 AP (apurinic/apyrimidinic) site pocket; other site 272634001467 DNA interaction; other site 272634001468 Metal-binding active site; metal-binding site 272634001469 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 272634001470 active site 272634001471 dimer interface [polypeptide binding]; other site 272634001472 magnesium binding site [ion binding]; other site 272634001473 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272634001474 active site 272634001475 phosphorylation site [posttranslational modification] 272634001476 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 272634001477 active site 272634001478 P-loop; other site 272634001479 phosphorylation site [posttranslational modification] 272634001480 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 272634001481 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: Php; COG1735 272634001482 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 272634001483 intersubunit interface [polypeptide binding]; other site 272634001484 active site 272634001485 Zn2+ binding site [ion binding]; other site 272634001486 Mycoplasma adhesin P1; Region: Adhesin_P1; pfam03257 272634001487 Protein of unknown function DUF16; Region: DUF16; pfam01519 272634001488 Trypsin-sensitive surface-exposed protein; Region: CytadhesinP1; pfam12378 272634001489 Trypsin-sensitive surface-exposed protein; Region: CytadhesinP1; pfam12378 272634001490 Protein of unknown function DUF16; Region: DUF16; pfam01519 272634001491 Lipoprotein; Region: Lipoprotein_3; pfam00938 272634001492 Mycoplasma MG185/MG260 protein; Region: Lipoprotein_X; pfam03305 272634001493 Putative mycoplasma lipoprotein, C-terminal region; Region: Lipoprotein_10; pfam03202 272634001494 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 272634001495 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272634001496 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272634001497 MG032/MG096/MG288 family 2; Region: DUF240; pfam03086 272634001498 MG032/MG096/MG288 family 1; Region: DUF237; pfam03072 272634001499 MG032/MG096/MG288 family 2; Region: DUF240; pfam03086 272634001500 MG032/MG096/MG288 family 1; Region: DUF237; pfam03072 272634001501 MG032/MG096/MG288 family 2; Region: DUF240; pfam03086 272634001502 Domain of unknown function (DUF4164); Region: DUF4164; pfam13747 272634001503 MG032/MG096/MG288 family 1; Region: DUF237; pfam03072 272634001504 MG032/MG096/MG288 family 1; Region: DUF237; pfam03072 272634001505 MG032/MG096/MG288 family 2; Region: DUF240; pfam03086 272634001506 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 272634001507 DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386 272634001508 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 272634001509 beta and beta' interface [polypeptide binding]; other site 272634001510 beta' and sigma factor interface [polypeptide binding]; other site 272634001511 Zn-binding [ion binding]; other site 272634001512 active site region [active] 272634001513 catalytic site [active] 272634001514 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 272634001515 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 272634001516 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 272634001517 G-loop; other site 272634001518 DNA binding site [nucleotide binding] 272634001519 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 272634001520 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 272634001521 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 272634001522 RPB1 interaction site [polypeptide binding]; other site 272634001523 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 272634001524 RPB10 interaction site [polypeptide binding]; other site 272634001525 RPB11 interaction site [polypeptide binding]; other site 272634001526 RPB3 interaction site [polypeptide binding]; other site 272634001527 RPB12 interaction site [polypeptide binding]; other site 272634001528 Predicted flavoprotein [General function prediction only]; Region: COG0431 272634001529 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 272634001530 Putative lysophospholipase; Region: Hydrolase_4; cl19140 272634001531 isoleucyl-tRNA synthetase; Region: ileS; TIGR00392 272634001532 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272634001533 active site 272634001534 HIGH motif; other site 272634001535 nucleotide binding site [chemical binding]; other site 272634001536 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 272634001537 active site 272634001538 KMSKS motif; other site 272634001539 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 272634001540 tRNA binding surface [nucleotide binding]; other site 272634001541 anticodon binding site; other site 272634001542 tRNA (cytidine(34)-2'-O)-methyltransferase; Region: tRNA_yibK_trmL; TIGR00185 272634001543 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 272634001544 S-adenosylmethionine binding site [chemical binding]; other site 272634001545 Protein of unknown function DUF16; Region: DUF16; pfam01519 272634001546 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 272634001547 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 272634001548 dimer interface [polypeptide binding]; other site 272634001549 substrate binding site [chemical binding]; other site 272634001550 metal binding sites [ion binding]; metal-binding site 272634001551 Retinal tissue protein; Region: Ret_tiss; pfam10044 272634001552 Penicillin-binding protein-related factor A, putative recombinase [General function prediction only]; Region: PrfA; COG3331 272634001553 Bacterial nucleoid DNA-binding protein [DNA replication, recombination, and repair]; Region: HimA; COG0776 272634001554 DNA binding site [nucleotide binding] 272634001555 dimer interface [polypeptide binding]; other site 272634001556 Domain of unknown function (DUF1951); Region: DUF1951; pfam09188 272634001557 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272634001558 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 272634001559 Walker A motif; other site 272634001560 ATP binding site [chemical binding]; other site 272634001561 Walker B motif; other site 272634001562 arginine finger; other site 272634001563 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272634001564 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 272634001565 Walker A motif; other site 272634001566 ATP binding site [chemical binding]; other site 272634001567 Walker B motif; other site 272634001568 arginine finger; other site 272634001569 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 272634001570 Thiamine kinase and related kinases [Coenzyme transport and metabolism]; Region: ycfN; COG0510 272634001571 Phosphotransferase enzyme family; Region: APH; pfam01636 272634001572 active site 272634001573 substrate binding site [chemical binding]; other site 272634001574 ATP binding site [chemical binding]; other site 272634001575 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 272634001576 nucleotide binding site [chemical binding]; other site 272634001577 butyrate kinase; Provisional; Region: PRK03011 272634001578 Holliday junction DNA helicase, RuvA subunit; Region: ruvA; TIGR00084 272634001579 RuvA N terminal domain; Region: RuvA_N; pfam01330 272634001580 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 272634001581 Holliday junction DNA helicase, RuvB subunit; Region: ruvB; TIGR00635 272634001582 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272634001583 Walker A motif; other site 272634001584 ATP binding site [chemical binding]; other site 272634001585 Walker B motif; other site 272634001586 arginine finger; other site 272634001587 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 272634001588 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 272634001589 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 272634001590 DNA binding site [nucleotide binding] 272634001591 active site 272634001592 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 272634001593 23S rRNA interface [nucleotide binding]; other site 272634001594 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 272634001595 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 272634001596 core dimer interface [polypeptide binding]; other site 272634001597 peripheral dimer interface [polypeptide binding]; other site 272634001598 L10 interface [polypeptide binding]; other site 272634001599 L11 interface [polypeptide binding]; other site 272634001600 putative EF-Tu interaction site [polypeptide binding]; other site 272634001601 putative EF-G interaction site [polypeptide binding]; other site 272634001602 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 272634001603 ribosomal protein S20; Region: S20; TIGR00029 272634001604 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 272634001605 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 272634001606 putative active site [active] 272634001607 substrate binding site [chemical binding]; other site 272634001608 putative cosubstrate binding site; other site 272634001609 catalytic site [active] 272634001610 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 272634001611 substrate binding site [chemical binding]; other site 272634001612 Domain of unknown function(DUF2779); Region: DUF2779; pfam11074 272634001613 dsRNA-specific ribonuclease [Transcription]; Region: Rnc; COG0571 272634001614 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 272634001615 dimerization interface [polypeptide binding]; other site 272634001616 active site 272634001617 metal binding site [ion binding]; metal-binding site 272634001618 fatty acid/phospholipid synthesis protein PlsX; Region: plsX; TIGR00182 272634001619 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 272634001620 DAK2 domain; Region: Dak2; pfam02734 272634001621 Dihydroxyacetone kinase family; Region: Dak1_2; pfam13684 272634001622 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 272634001623 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272634001624 RNA binding surface [nucleotide binding]; other site 272634001625 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 272634001626 active site 272634001627 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 272634001628 DHH family; Region: DHH; pfam01368 272634001629 DHHA1 domain; Region: DHHA1; pfam02272 272634001630 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 272634001631 tRNA sulfurtransferase ThiI; Region: TIGR00342 272634001632 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 272634001633 Ligand Binding Site [chemical binding]; other site 272634001634 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 272634001635 threonyl-tRNA synthetase; Region: thrS; TIGR00418 272634001636 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 272634001637 active site 272634001638 dimer interface [polypeptide binding]; other site 272634001639 motif 1; other site 272634001640 motif 2; other site 272634001641 motif 3; other site 272634001642 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 272634001643 anticodon binding site; other site 272634001644 Protein of unknown function (DUF3217); Region: DUF3217; pfam11506 272634001645 arginyl-tRNA synthetase; Region: argS; TIGR00456 272634001646 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 272634001647 active site 272634001648 HIGH motif; other site 272634001649 KMSK motif region; other site 272634001650 tRNA binding surface [nucleotide binding]; other site 272634001651 DALR anticodon binding domain; Region: DALR_1; smart00836 272634001652 anticodon binding site; other site 272634001653 glucose-inhibited division protein A; Region: gidA; TIGR00136 272634001654 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 272634001655 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 272634001656 rRNA small subunit methyltransferase G; Region: GidB; pfam02527 272634001657 Arginine deiminase [Amino acid transport and metabolism]; Region: ArcA; COG2235 272634001658 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 272634001659 ATP-binding site [chemical binding]; other site 272634001660 Sugar specificity; other site 272634001661 Pyrimidine base specificity; other site 272634001662 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 272634001663 ATP binding pocket [chemical binding]; other site 272634001664 Mg binding site [ion binding]; other site 272634001665 NAD binding pocket [chemical binding]; other site 272634001666 active-site loop [active] 272634001667 homodimer interface [polypeptide binding]; other site 272634001668 GTP1/OBG; Region: GTP1_OBG; pfam01018 272634001669 GTPase CgtA; Reviewed; Region: obgE; PRK12297 272634001670 Obg GTPase; Region: Obg; cd01898 272634001671 G1 box; other site 272634001672 GTP/Mg2+ binding site [chemical binding]; other site 272634001673 Switch I region; other site 272634001674 G2 box; other site 272634001675 G3 box; other site 272634001676 Switch II region; other site 272634001677 G4 box; other site 272634001678 G5 box; other site 272634001679 Obg family GTPase CgtA, C-terminal extension; Region: Obg_CgtA_exten; TIGR03595 272634001680 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 272634001681 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 272634001682 tetramer interface [polypeptide binding]; other site 272634001683 catalytic Zn binding site [ion binding]; other site 272634001684 NADP binding site [chemical binding]; other site 272634001685 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 272634001686 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 272634001687 active site 272634001688 catalytic site [active] 272634001689 EAGR box; Region: EAGR_box; TIGR03834 272634001690 EAGR box; Region: EAGR_box; TIGR03834 272634001691 EAGR box; Region: EAGR_box; TIGR03834 272634001692 EAGR box; Region: EAGR_box; TIGR03834 272634001693 EAGR box; Region: EAGR_box; TIGR03834 272634001694 EAGR box; Region: EAGR_box; TIGR03834 272634001695 GTP-binding protein Era; Region: era; TIGR00436 272634001696 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 272634001697 G1 box; other site 272634001698 GTP/Mg2+ binding site [chemical binding]; other site 272634001699 Switch I region; other site 272634001700 G2 box; other site 272634001701 Switch II region; other site 272634001702 G3 box; other site 272634001703 G4 box; other site 272634001704 G5 box; other site 272634001705 KH domain; Region: KH_2; pfam07650 272634001706 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG0319 272634001707 Ewing's tumor-associated antigen 1 homologue; Region: ETAA1; pfam15350 272634001708 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 272634001709 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39E; cd02424 272634001710 putative active site [active] 272634001711 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 272634001712 Walker A/P-loop; other site 272634001713 ATP binding site [chemical binding]; other site 272634001714 Q-loop/lid; other site 272634001715 ABC transporter signature motif; other site 272634001716 Walker B; other site 272634001717 D-loop; other site 272634001718 H-loop/switch region; other site 272634001719 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 272634001720 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 272634001721 interface (dimer of trimers) [polypeptide binding]; other site 272634001722 Substrate-binding/catalytic site; other site 272634001723 Zn-binding sites [ion binding]; other site 272634001724 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 272634001725 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 272634001726 ring oligomerisation interface [polypeptide binding]; other site 272634001727 ATP/Mg binding site [chemical binding]; other site 272634001728 stacking interactions; other site 272634001729 hinge regions; other site 272634001730 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 272634001731 oligomerisation interface [polypeptide binding]; other site 272634001732 mobile loop; other site 272634001733 roof hairpin; other site 272634001734 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 272634001735 dimer interface [polypeptide binding]; other site 272634001736 active site 272634001737 glycine-pyridoxal phosphate binding site [chemical binding]; other site 272634001738 folate binding site [chemical binding]; other site 272634001739 Putative peptidase (DUF31); Region: DUF31; pfam01732 272634001740 OPT oligopeptide transporter protein; Region: OPT; cl14607 272634001741 Peptidase S7, Flavivirus NS3 serine protease; Region: Peptidase_S7; pfam00949 272634001742 Putative peptidase (DUF31); Region: DUF31; pfam01732 272634001743 Putative peptidase (DUF31); Region: DUF31; pfam01732 272634001744 Putative peptidase (DUF31); Region: DUF31; pfam01732 272634001745 Putative peptidase (DUF31); Region: DUF31; pfam01732 272634001746 Putative peptidase (DUF31); Region: DUF31; pfam01732 272634001747 Peptidase S7, Flavivirus NS3 serine protease; Region: Peptidase_S7; pfam00949 272634001748 Putative peptidase (DUF31); Region: DUF31; pfam01732 272634001749 Putative peptidase (DUF31); Region: DUF31; pfam01732 272634001750 Peptidase S7, Flavivirus NS3 serine protease; Region: Peptidase_S7; pfam00949 272634001751 Peptidase S7, Flavivirus NS3 serine protease; Region: Peptidase_S7; pfam00949 272634001752 Putative peptidase (DUF31); Region: DUF31; pfam01732 272634001753 Putative peptidase (DUF31); Region: DUF31; pfam01732 272634001754 Putative peptidase (DUF31); Region: DUF31; pfam01732 272634001755 sugar-phosphate isomerase, RpiB/LacA/LacB family; Region: rpiB_lacA_lacB; TIGR00689 272634001756 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 272634001757 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00539 272634001758 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 272634001759 gamma subunit interface [polypeptide binding]; other site 272634001760 epsilon subunit interface [polypeptide binding]; other site 272634001761 LBP interface [polypeptide binding]; other site 272634001762 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 272634001763 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 272634001764 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 272634001765 alpha subunit interaction interface [polypeptide binding]; other site 272634001766 Walker A motif; other site 272634001767 ATP binding site [chemical binding]; other site 272634001768 Walker B motif; other site 272634001769 inhibitor binding site; inhibition site 272634001770 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 272634001771 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 272634001772 core domain interface [polypeptide binding]; other site 272634001773 delta subunit interface [polypeptide binding]; other site 272634001774 epsilon subunit interface [polypeptide binding]; other site 272634001775 proton translocating ATP synthase, F1 alpha subunit; Region: atpA; TIGR00962 272634001776 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 272634001777 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 272634001778 beta subunit interaction interface [polypeptide binding]; other site 272634001779 Walker A motif; other site 272634001780 ATP binding site [chemical binding]; other site 272634001781 Walker B motif; other site 272634001782 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 272634001783 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; COG0712 272634001784 F0F1 ATP synthase subunit B; Validated; Region: PRK06231 272634001785 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 272634001786 F0F1 ATP synthase subunit C; Validated; Region: PRK07159 272634001787 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 272634001788 enolase; Provisional; Region: eno; PRK00077 272634001789 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 272634001790 dimer interface [polypeptide binding]; other site 272634001791 metal binding site [ion binding]; metal-binding site 272634001792 substrate binding pocket [chemical binding]; other site 272634001793 methionine-S-sulfoxide reductase; Region: msrA; TIGR00401 272634001794 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 272634001795 PhoU domain; Region: PhoU; pfam01895 272634001796 PhoU domain; Region: PhoU; pfam01895 272634001797 Bacteriophage Rz lysis protein; Region: Phage_lysis; pfam03245 272634001798 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 272634001799 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 272634001800 Walker A/P-loop; other site 272634001801 ATP binding site [chemical binding]; other site 272634001802 Q-loop/lid; other site 272634001803 ABC transporter signature motif; other site 272634001804 Walker B; other site 272634001805 D-loop; other site 272634001806 H-loop/switch region; other site 272634001807 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 272634001808 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272634001809 dimer interface [polypeptide binding]; other site 272634001810 conserved gate region; other site 272634001811 putative PBP binding loops; other site 272634001812 ABC-ATPase subunit interface; other site 272634001813 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 272634001814 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 272634001815 dimer interface [polypeptide binding]; other site 272634001816 conserved gate region; other site 272634001817 putative PBP binding loops; other site 272634001818 ABC-ATPase subunit interface; other site 272634001819 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 272634001820 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272634001821 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 272634001822 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272634001823 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 272634001824 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 272634001825 23S rRNA interface [nucleotide binding]; other site 272634001826 L3 interface [polypeptide binding]; other site 272634001827 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05896 272634001828 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272634001829 Walker A motif; other site 272634001830 ATP binding site [chemical binding]; other site 272634001831 Walker B motif; other site 272634001832 arginine finger; other site 272634001833 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 272634001834 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 272634001835 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 272634001836 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 272634001837 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 272634001838 conserved hypothetical protein; Region: MG423; TIGR00649 272634001839 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 272634001840 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 272634001841 16S/18S rRNA binding site [nucleotide binding]; other site 272634001842 S13e-L30e interaction site [polypeptide binding]; other site 272634001843 25S rRNA binding site [nucleotide binding]; other site 272634001844 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 272634001845 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 272634001846 ATP binding site [chemical binding]; other site 272634001847 Mg++ binding site [ion binding]; other site 272634001848 motif III; other site 272634001849 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 272634001850 nucleotide binding region [chemical binding]; other site 272634001851 ATP-binding site [chemical binding]; other site 272634001852 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 272634001853 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 272634001854 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 272634001855 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 272634001856 DNA binding residues [nucleotide binding] 272634001857 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 272634001858 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 272634001859 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 272634001860 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 272634001861 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 272634001862 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 272634001863 substrate binding site [chemical binding]; other site 272634001864 dimer interface [polypeptide binding]; other site 272634001865 catalytic triad [active] 272634001866 Uncharacterized conserved protein [Function unknown]; Region: COG1284 272634001867 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272634001868 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl19873 272634001869 translation elongation factor Ts; Region: tsf; TIGR00116 272634001870 UBA/TS-N domain; Region: UBA; pfam00627 272634001871 Uridylate kinase [Nucleotide transport and metabolism]; Region: PyrH; COG0528 272634001872 nucleotide binding site [chemical binding]; other site 272634001873 substrate binding site [chemical binding]; other site 272634001874 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 272634001875 hinge region; other site 272634001876 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 272634001877 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 272634001878 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272634001879 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 272634001880 Lipoprotein; Region: Lipoprotein_3; pfam00938 272634001881 Lipoprotein; Region: Lipoprotein_3; pfam00938 272634001882 Lipoprotein; Region: Lipoprotein_3; pfam00938 272634001883 Lipoprotein; Region: Lipoprotein_3; pfam00938 272634001884 Lipoprotein; Region: Lipoprotein_3; pfam00938 272634001885 Lipoprotein; Region: Lipoprotein_3; pfam00938 272634001886 Lipoprotein; Region: Lipoprotein_3; pfam00938 272634001887 Lipoprotein; Region: Lipoprotein_3; pfam00938 272634001888 Lipoprotein; Region: Lipoprotein_3; pfam00938 272634001889 Lipoprotein; Region: Lipoprotein_3; pfam00938 272634001890 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 272634001891 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 272634001892 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 272634001893 active site 272634001894 P-loop; other site 272634001895 phosphorylation site [posttranslational modification] 272634001896 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 272634001897 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 272634001898 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 272634001899 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 272634001900 active site 272634001901 phosphorylation site [posttranslational modification] 272634001902 Lipoprotein; Region: Lipoprotein_3; pfam00938 272634001903 Protein of unknown function DUF16; Region: DUF16; pfam01519 272634001904 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 272634001905 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 272634001906 GTP/Mg2+ binding site [chemical binding]; other site 272634001907 G4 box; other site 272634001908 G1 box; other site 272634001909 Switch I region; other site 272634001910 G2 box; other site 272634001911 G3 box; other site 272634001912 Switch II region; other site 272634001913 Uncharacterized conserved protein [Function unknown]; Region: COG1284 272634001914 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 272634001915 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl19873 272634001916 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 272634001917 tRNA (guanine-N1)-methyltransferase; Region: trmD; TIGR00088 272634001918 ribosomal protein S16; Region: S16; TIGR00002 272634001919 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 272634001920 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 272634001921 methionine-R-sulfoxide reductase; Region: TIGR00357 272634001922 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 272634001923 putative tRNA-binding site [nucleotide binding]; other site 272634001924 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 272634001925 elongation factor Tu; Reviewed; Region: PRK00049 272634001926 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 272634001927 G1 box; other site 272634001928 GEF interaction site [polypeptide binding]; other site 272634001929 GTP/Mg2+ binding site [chemical binding]; other site 272634001930 Switch I region; other site 272634001931 G2 box; other site 272634001932 G3 box; other site 272634001933 Switch II region; other site 272634001934 G4 box; other site 272634001935 G5 box; other site 272634001936 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 272634001937 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 272634001938 Antibiotic Binding Site [chemical binding]; other site 272634001939 Protein of unknown function (DUF1600); Region: DUF1600; pfam07667 272634001940 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 272634001941 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 272634001942 active site 272634001943 tetramer interface; other site 272634001944 Organic hydroperoxide reductase [Secondary metabolites biosynthesis, transport and catabolism]; Region: osmC; COG1764 272634001945 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 272634001946 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 272634001947 active site 272634001948 HIGH motif; other site 272634001949 dimer interface [polypeptide binding]; other site 272634001950 KMSKS motif; other site 272634001951 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 272634001952 RNA binding surface [nucleotide binding]; other site 272634001953 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 272634001954 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272634001955 Walker A motif; other site 272634001956 ATP binding site [chemical binding]; other site 272634001957 Walker B motif; other site 272634001958 arginine finger; other site 272634001959 Peptidase family M41; Region: Peptidase_M41; pfam01434 272634001960 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 272634001961 active site 272634001962 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [Lipid metabolism]; Region: IspF; COG0245 272634001963 homotrimer interaction site [polypeptide binding]; other site 272634001964 zinc binding site [ion binding]; other site 272634001965 CDP-binding sites; other site 272634001966 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 272634001967 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 272634001968 NAD binding site [chemical binding]; other site 272634001969 dimer interface [polypeptide binding]; other site 272634001970 tetramer (dimer of dimers) interface [polypeptide binding]; other site 272634001971 substrate binding site [chemical binding]; other site 272634001972 Protein of unknown function DUF16; Region: DUF16; pfam01519 272634001973 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 272634001974 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 272634001975 Zn2+ binding site [ion binding]; other site 272634001976 Mg2+ binding site [ion binding]; other site 272634001977 glutamyl-tRNA synthetase, bacterial family; Region: gltX_bact; TIGR00464 272634001978 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 272634001979 active site 272634001980 HIGH motif; other site 272634001981 KMSKS motif; other site 272634001982 dimethyladenosine transferase; Region: ksgA; TIGR00755 272634001983 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02201 272634001984 ribonuclease P protein component, eubacterial; Region: rnpA; TIGR00188 272634001985 Ribosomal protein L34; Region: Ribosomal_L34; pfam00468 272634001986 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272634001987 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272634001988 Walker A/P-loop; other site 272634001989 ATP binding site [chemical binding]; other site 272634001990 Q-loop/lid; other site 272634001991 ABC transporter signature motif; other site 272634001992 Walker B; other site 272634001993 D-loop; other site 272634001994 H-loop/switch region; other site 272634001995 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 272634001996 FtsX-like permease family; Region: FtsX; pfam02687 272634001997 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 272634001998 FtsX-like permease family; Region: FtsX; pfam02687 272634001999 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 272634002000 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 272634002001 Walker A/P-loop; other site 272634002002 ATP binding site [chemical binding]; other site 272634002003 Q-loop/lid; other site 272634002004 ABC transporter signature motif; other site 272634002005 Walker B; other site 272634002006 D-loop; other site 272634002007 H-loop/switch region; other site 272634002008 DnaA N-terminal domain; Region: DnaA_N; pfam11638 272634002009 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 272634002010 Casein kinase II regulatory subunit; Region: CK_II_beta; cl02099 272634002011 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 272634002012 Walker A motif; other site 272634002013 ATP binding site [chemical binding]; other site 272634002014 Walker B motif; other site 272634002015 arginine finger; other site 272634002016 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 272634002017 DnaA box-binding interface [nucleotide binding]; other site 272634002018 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 272634002019 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 272634002020 P-loop; other site 272634002021 Magnesium ion binding site [ion binding]; other site