-- dump date 20140619_161953 -- class Genbank::misc_feature -- table misc_feature_note -- id note 483219000001 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 483219000002 Uncharacterized conserved protein [Function unknown]; Region: COG1479 483219000003 Protein of unknown function DUF262; Region: DUF262; pfam03235 483219000004 Uncharacterized conserved protein [Function unknown]; Region: COG3472 483219000005 Winged helix-turn helix; Region: HTH_29; pfam13551 483219000006 Homeodomain-like domain; Region: HTH_32; pfam13565 483219000007 Integrase core domain; Region: rve; pfam00665 483219000008 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219000009 Walker A motif; other site 483219000010 ATP binding site [chemical binding]; other site 483219000011 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 483219000012 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 483219000013 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 483219000014 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 483219000015 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 483219000016 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 483219000017 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 483219000018 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 483219000019 Epoxide hydrolase N terminus; Region: EHN; pfam06441 483219000020 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 483219000021 Predicted transcriptional regulator [Transcription]; Region: COG2378 483219000022 HTH domain; Region: HTH_11; pfam08279 483219000023 WYL domain; Region: WYL; pfam13280 483219000024 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 483219000025 Catalytic site [active] 483219000026 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 483219000027 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219000028 Walker A/P-loop; other site 483219000029 ATP binding site [chemical binding]; other site 483219000030 Q-loop/lid; other site 483219000031 ABC transporter signature motif; other site 483219000032 Walker B; other site 483219000033 D-loop; other site 483219000034 H-loop/switch region; other site 483219000035 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 483219000036 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 483219000037 homodimer interface [polypeptide binding]; other site 483219000038 active site 483219000039 TDP-binding site; other site 483219000040 acceptor substrate-binding pocket; other site 483219000041 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 483219000042 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 483219000043 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 483219000044 Soluble P-type ATPase [General function prediction only]; Region: COG4087 483219000045 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 483219000046 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 483219000047 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 483219000048 Predicted transcriptional regulators [Transcription]; Region: COG1733 483219000049 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 483219000050 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 483219000051 short chain dehydrogenase; Provisional; Region: PRK06523 483219000052 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 483219000053 NAD(P) binding site [chemical binding]; other site 483219000054 active site 483219000055 Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135 483219000056 Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135 483219000057 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 483219000058 GAF domain; Region: GAF_2; pfam13185 483219000059 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219000060 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219000061 dimer interface [polypeptide binding]; other site 483219000062 phosphorylation site [posttranslational modification] 483219000063 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219000064 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219000065 ATP binding site [chemical binding]; other site 483219000066 G-X-G motif; other site 483219000067 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 483219000068 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 483219000069 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 483219000070 DNA binding residues [nucleotide binding] 483219000071 Predicted transporter component [General function prediction only]; Region: COG2391 483219000072 Sulphur transport; Region: Sulf_transp; pfam04143 483219000073 Predicted transporter component [General function prediction only]; Region: COG2391 483219000074 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 483219000075 HEAT repeats; Region: HEAT_2; pfam13646 483219000076 HEAT repeats; Region: HEAT_2; pfam13646 483219000077 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 483219000078 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 483219000079 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 483219000080 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 483219000081 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 483219000082 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 483219000083 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 483219000084 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 483219000085 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 483219000086 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 483219000087 Uncharacterized conserved protein [Function unknown]; Region: COG5649 483219000088 Deoxyhypusine synthase; Region: DS; cl00826 483219000089 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 483219000090 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 483219000091 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 483219000092 FAD binding domain; Region: FAD_binding_4; pfam01565 483219000093 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 483219000094 NAD(P) binding site [chemical binding]; other site 483219000095 active site 483219000096 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 483219000097 putative acyl-acceptor binding pocket; other site 483219000098 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 483219000099 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 483219000100 NAD(P) binding site [chemical binding]; other site 483219000101 active site 483219000102 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 483219000103 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 483219000104 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 483219000105 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 483219000106 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483219000107 Transcriptional regulator [Transcription]; Region: LysR; COG0583 483219000108 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 483219000109 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 483219000110 putative effector binding pocket; other site 483219000111 dimerization interface [polypeptide binding]; other site 483219000112 potential frameshift: common BLAST hit: gi|108756955|ref|YP_631380.1| ATP-dependent helicase HrpA 483219000113 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 483219000114 potential frameshift: common BLAST hit: gi|311106301|ref|YP_003979154.1| GntR family transcriptional regulator 483219000115 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 483219000116 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 483219000117 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 483219000118 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 483219000119 Zn binding site [ion binding]; other site 483219000120 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 483219000121 NodB motif; other site 483219000122 active site 483219000123 catalytic site [active] 483219000124 metal binding site [ion binding]; metal-binding site 483219000125 PemK-like protein; Region: PemK; pfam02452 483219000126 Cupin; Region: Cupin_6; pfam12852 483219000127 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 483219000128 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 483219000129 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 483219000130 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 483219000131 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 483219000132 NAD(P) binding site [chemical binding]; other site 483219000133 active site 483219000134 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 483219000135 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 483219000136 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 483219000137 Di-iron ligands [ion binding]; other site 483219000138 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 483219000139 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 483219000140 cleavage site 483219000141 active site 483219000142 substrate binding sites [chemical binding]; other site 483219000143 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 483219000144 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 483219000145 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 483219000146 substrate binding pocket [chemical binding]; other site 483219000147 catalytic triad [active] 483219000148 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 483219000149 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 483219000150 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 483219000151 putative ADP-ribose binding site [chemical binding]; other site 483219000152 putative active site [active] 483219000153 Peptidase family M48; Region: Peptidase_M48; cl12018 483219000154 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 483219000155 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 483219000156 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 483219000157 haloalkane dehalogenase; Provisional; Region: PRK03592 483219000158 Predicted transcriptional regulator [Transcription]; Region: COG1959 483219000159 Transcriptional regulator; Region: Rrf2; pfam02082 483219000160 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 483219000161 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 483219000162 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 483219000163 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 483219000164 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 483219000165 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 483219000166 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 483219000167 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 483219000168 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 483219000169 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 483219000170 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 483219000171 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 483219000172 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 483219000173 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 483219000174 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 483219000175 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 483219000176 NAD(P) binding site [chemical binding]; other site 483219000177 active site 483219000178 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 483219000179 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 483219000180 NAD(P) binding site [chemical binding]; other site 483219000181 active site 483219000182 cyclic beta-1,2-glucan ABC transporter; Provisional; Region: PRK13657 483219000183 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 483219000184 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219000185 Walker A/P-loop; other site 483219000186 ATP binding site [chemical binding]; other site 483219000187 Q-loop/lid; other site 483219000188 ABC transporter signature motif; other site 483219000189 Walker B; other site 483219000190 D-loop; other site 483219000191 H-loop/switch region; other site 483219000192 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 483219000193 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 483219000194 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 483219000195 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 483219000196 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH9; cd08269 483219000197 putative NAD(P) binding site [chemical binding]; other site 483219000198 catalytic Zn binding site [ion binding]; other site 483219000199 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 483219000200 active site 483219000201 catalytic residues [active] 483219000202 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3664 483219000203 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219000204 S-adenosylmethionine binding site [chemical binding]; other site 483219000205 glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511 483219000206 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 483219000207 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 483219000208 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 483219000209 Right handed beta helix region; Region: Beta_helix; pfam13229 483219000210 Bacterial Ig-like domain 2; Region: BID_2; smart00635 483219000211 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 483219000212 Glyco_18 domain; Region: Glyco_18; smart00636 483219000213 active site 483219000214 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 483219000215 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 483219000216 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 483219000217 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 483219000218 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 483219000219 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 483219000220 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 483219000221 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 483219000222 DNA polymerase type-B family; Region: POLBc; smart00486 483219000223 active site 483219000224 catalytic site [active] 483219000225 substrate binding site [chemical binding]; other site 483219000226 DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both...; Region: POLBc; cl10023 483219000227 active site 483219000228 metal-binding site 483219000229 HTH domain; Region: HTH_11; pfam08279 483219000230 WYL domain; Region: WYL; pfam13280 483219000231 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 483219000232 DNA-binding site [nucleotide binding]; DNA binding site 483219000233 RNA-binding motif; other site 483219000234 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 483219000235 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 483219000236 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 483219000237 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 483219000238 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 483219000239 iron-sulfur cluster [ion binding]; other site 483219000240 [2Fe-2S] cluster binding site [ion binding]; other site 483219000241 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 483219000242 hydrophobic ligand binding site; other site 483219000243 Condensation domain; Region: Condensation; pfam00668 483219000244 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219000245 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219000246 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 483219000247 acyl-activating enzyme (AAE) consensus motif; other site 483219000248 AMP binding site [chemical binding]; other site 483219000249 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219000250 Condensation domain; Region: Condensation; pfam00668 483219000251 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219000252 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219000253 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 483219000254 acyl-activating enzyme (AAE) consensus motif; other site 483219000255 AMP binding site [chemical binding]; other site 483219000256 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219000257 Condensation domain; Region: Condensation; pfam00668 483219000258 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219000259 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219000260 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 483219000261 acyl-activating enzyme (AAE) consensus motif; other site 483219000262 AMP binding site [chemical binding]; other site 483219000263 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219000264 Condensation domain; Region: Condensation; pfam00668 483219000265 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219000266 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219000267 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 483219000268 acyl-activating enzyme (AAE) consensus motif; other site 483219000269 AMP binding site [chemical binding]; other site 483219000270 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219000271 Condensation domain; Region: Condensation; pfam00668 483219000272 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219000273 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 483219000274 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 483219000275 acyl-activating enzyme (AAE) consensus motif; other site 483219000276 AMP binding site [chemical binding]; other site 483219000277 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219000278 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 483219000279 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 483219000280 FtsX-like permease family; Region: FtsX; pfam02687 483219000281 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 483219000282 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 483219000283 acyl-activating enzyme (AAE) consensus motif; other site 483219000284 AMP binding site [chemical binding]; other site 483219000285 active site 483219000286 CoA binding site [chemical binding]; other site 483219000287 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 483219000288 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 483219000289 putative NADP binding site [chemical binding]; other site 483219000290 active site 483219000291 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219000292 Methyltransferase domain; Region: Methyltransf_23; pfam13489 483219000293 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219000294 S-adenosylmethionine binding site [chemical binding]; other site 483219000295 Fatty acid desaturase; Region: FA_desaturase; pfam00487 483219000296 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 483219000297 putative di-iron ligands [ion binding]; other site 483219000298 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 483219000299 capreomycidine synthase; Region: viomycin_VioD; TIGR03947 483219000300 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 483219000301 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483219000302 homodimer interface [polypeptide binding]; other site 483219000303 catalytic residue [active] 483219000304 Methyltransferase domain; Region: Methyltransf_18; pfam12847 483219000305 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 483219000306 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 483219000307 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 483219000308 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 483219000309 Walker A/P-loop; other site 483219000310 ATP binding site [chemical binding]; other site 483219000311 Q-loop/lid; other site 483219000312 ABC transporter signature motif; other site 483219000313 Walker B; other site 483219000314 D-loop; other site 483219000315 H-loop/switch region; other site 483219000316 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 483219000317 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 483219000318 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 483219000319 putative acyl-acceptor binding pocket; other site 483219000320 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 483219000321 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 483219000322 putative NAD(P) binding site [chemical binding]; other site 483219000323 active site 483219000324 putative substrate binding site [chemical binding]; other site 483219000325 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 483219000326 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 483219000327 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 483219000328 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 483219000329 putative active site [active] 483219000330 Domain of unknown function DUF87; Region: DUF87; pfam01935 483219000331 AAA-like domain; Region: AAA_10; pfam12846 483219000332 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 483219000333 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 483219000334 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 483219000335 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 483219000336 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 483219000337 glutamine binding [chemical binding]; other site 483219000338 catalytic triad [active] 483219000339 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 483219000340 Aminotransferase class IV; Region: Aminotran_4; pfam01063 483219000341 substrate-cofactor binding pocket; other site 483219000342 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 483219000343 Uncharacterized conserved protein [Function unknown]; Region: COG2966 483219000344 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 483219000345 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 483219000346 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 483219000347 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 483219000348 putative catalytic site [active] 483219000349 putative metal binding site [ion binding]; other site 483219000350 putative phosphate binding site [ion binding]; other site 483219000351 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 483219000352 Lamin Tail Domain; Region: LTD; pfam00932 483219000353 Predicted membrane protein [Function unknown]; Region: COG1238 483219000354 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 483219000355 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 483219000356 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219000357 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219000358 active site 483219000359 ATP binding site [chemical binding]; other site 483219000360 substrate binding site [chemical binding]; other site 483219000361 activation loop (A-loop); other site 483219000362 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483219000363 putative substrate translocation pore; other site 483219000364 Transcriptional regulator [Transcription]; Region: LysR; COG0583 483219000365 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 483219000366 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 483219000367 dimerization interface [polypeptide binding]; other site 483219000368 TfoX N-terminal domain; Region: TfoX_N; pfam04993 483219000369 AMP-binding domain protein; Validated; Region: PRK08315 483219000370 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 483219000371 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 483219000372 acyl-activating enzyme (AAE) consensus motif; other site 483219000373 putative AMP binding site [chemical binding]; other site 483219000374 putative active site [active] 483219000375 putative CoA binding site [chemical binding]; other site 483219000376 serine O-acetyltransferase; Region: cysE; TIGR01172 483219000377 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 483219000378 trimer interface [polypeptide binding]; other site 483219000379 active site 483219000380 substrate binding site [chemical binding]; other site 483219000381 CoA binding site [chemical binding]; other site 483219000382 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 483219000383 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 483219000384 dimer interface [polypeptide binding]; other site 483219000385 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483219000386 catalytic residue [active] 483219000387 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 483219000388 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 483219000389 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 483219000390 catalytic residue [active] 483219000391 Cytochrome c; Region: Cytochrom_C; pfam00034 483219000392 uncharacterized proteins similar to the Aspergillus nidulans lactam utilization protein LamB; Region: LamB_YcsF_like_1; cd10801 483219000393 putative active site [active] 483219000394 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 483219000395 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 483219000396 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 483219000397 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 483219000398 GAF domain; Region: GAF_3; pfam13492 483219000399 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219000400 Walker A motif; other site 483219000401 ATP binding site [chemical binding]; other site 483219000402 Walker B motif; other site 483219000403 arginine finger; other site 483219000404 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 483219000405 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 483219000406 dimer interface [polypeptide binding]; other site 483219000407 decamer (pentamer of dimers) interface [polypeptide binding]; other site 483219000408 catalytic triad [active] 483219000409 peroxidatic and resolving cysteines [active] 483219000410 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 483219000411 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 483219000412 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 483219000413 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 483219000414 dimerization interface [polypeptide binding]; other site 483219000415 DPS ferroxidase diiron center [ion binding]; other site 483219000416 ion pore; other site 483219000417 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 483219000418 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 483219000419 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483219000420 homodimer interface [polypeptide binding]; other site 483219000421 catalytic residue [active] 483219000422 Methyltransferase domain; Region: Methyltransf_31; pfam13847 483219000423 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219000424 S-adenosylmethionine binding site [chemical binding]; other site 483219000425 Amino acid permease; Region: AA_permease_2; pfam13520 483219000426 muropeptide transporter; Reviewed; Region: ampG; PRK11902 483219000427 muropeptide transporter; Validated; Region: ampG; cl17669 483219000428 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 483219000429 endonuclease III; Region: ENDO3c; smart00478 483219000430 minor groove reading motif; other site 483219000431 helix-hairpin-helix signature motif; other site 483219000432 substrate binding pocket [chemical binding]; other site 483219000433 active site 483219000434 Hemerythrin-like domain; Region: Hr-like; cd12108 483219000435 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 483219000436 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 483219000437 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 483219000438 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 483219000439 [2Fe-2S] cluster binding site [ion binding]; other site 483219000440 Gas vesicle protein; Region: Gas_vesicle; cl02954 483219000441 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 483219000442 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219000443 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219000444 dimer interface [polypeptide binding]; other site 483219000445 phosphorylation site [posttranslational modification] 483219000446 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219000447 ATP binding site [chemical binding]; other site 483219000448 Mg2+ binding site [ion binding]; other site 483219000449 G-X-G motif; other site 483219000450 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219000451 Response regulator receiver domain; Region: Response_reg; pfam00072 483219000452 active site 483219000453 phosphorylation site [posttranslational modification] 483219000454 intermolecular recognition site; other site 483219000455 dimerization interface [polypeptide binding]; other site 483219000456 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 483219000457 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 483219000458 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 483219000459 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 483219000460 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 483219000461 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 483219000462 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 483219000463 Walker A/P-loop; other site 483219000464 ATP binding site [chemical binding]; other site 483219000465 Q-loop/lid; other site 483219000466 ABC transporter signature motif; other site 483219000467 Walker B; other site 483219000468 D-loop; other site 483219000469 H-loop/switch region; other site 483219000470 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 483219000471 putative hydrophobic ligand binding site [chemical binding]; other site 483219000472 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 483219000473 TIGR01777 family protein; Region: yfcH 483219000474 NAD(P) binding site [chemical binding]; other site 483219000475 active site 483219000476 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 483219000477 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 483219000478 Predicted lipoprotein of unknown function (DUF2380); Region: DUF2380; cl15289 483219000479 Protein of unknown function (Gmx_para_CXXCG); Region: Gmx_para_CXXCG; pfam09535 483219000480 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 483219000481 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 483219000482 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 483219000483 ligand binding site [chemical binding]; other site 483219000484 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219000485 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 483219000486 Walker A motif; other site 483219000487 ATP binding site [chemical binding]; other site 483219000488 Walker B motif; other site 483219000489 arginine finger; other site 483219000490 Winged helix-turn helix; Region: HTH_29; pfam13551 483219000491 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 483219000492 Integrase core domain; Region: rve; pfam00665 483219000493 Protein of unknown function (DUF2379); Region: DUF2379; cl15283 483219000494 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 483219000495 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 483219000496 ATP binding site [chemical binding]; other site 483219000497 putative Mg++ binding site [ion binding]; other site 483219000498 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 483219000499 nucleotide binding region [chemical binding]; other site 483219000500 ATP-binding site [chemical binding]; other site 483219000501 ferrochelatase; Reviewed; Region: hemH; PRK00035 483219000502 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 483219000503 C-terminal domain interface [polypeptide binding]; other site 483219000504 active site 483219000505 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 483219000506 active site 483219000507 N-terminal domain interface [polypeptide binding]; other site 483219000508 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 483219000509 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 483219000510 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 483219000511 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 483219000512 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 483219000513 active site 483219000514 catalytic site [active] 483219000515 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 483219000516 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 483219000517 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 483219000518 active site 483219000519 catalytic site [active] 483219000520 SWIB/MDM2 domain; Region: SWIB; pfam02201 483219000521 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 483219000522 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 483219000523 NAD(P) binding site [chemical binding]; other site 483219000524 active site 483219000525 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 483219000526 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 483219000527 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 483219000528 fatty acyl-CoA reductase; Region: PLN02996 483219000529 NAD(P) binding site [chemical binding]; other site 483219000530 Male sterility protein; Region: NAD_binding_4; pfam07993 483219000531 active site 483219000532 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 483219000533 active site 483219000534 C-terminal domain of fatty acyl CoA reductases; Region: FAR_C; cd09071 483219000535 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 483219000536 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 483219000537 acyl-activating enzyme (AAE) consensus motif; other site 483219000538 putative AMP binding site [chemical binding]; other site 483219000539 putative active site [active] 483219000540 putative CoA binding site [chemical binding]; other site 483219000541 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 483219000542 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 483219000543 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 483219000544 putative acyl-acceptor binding pocket; other site 483219000545 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 483219000546 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 483219000547 NAD(P) binding site [chemical binding]; other site 483219000548 active site 483219000549 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 483219000550 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 483219000551 phosphopeptide binding site; other site 483219000552 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 483219000553 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 483219000554 metal binding site [ion binding]; metal-binding site 483219000555 active site 483219000556 I-site; other site 483219000557 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 483219000558 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 483219000559 ligand binding site; other site 483219000560 oligomer interface; other site 483219000561 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 483219000562 dimer interface [polypeptide binding]; other site 483219000563 N-terminal domain interface [polypeptide binding]; other site 483219000564 sulfate 1 binding site; other site 483219000565 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 483219000566 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 483219000567 Coenzyme A binding pocket [chemical binding]; other site 483219000568 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 483219000569 hypothetical protein; Reviewed; Region: PRK09588 483219000570 short chain dehydrogenase; Provisional; Region: PRK07062 483219000571 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 483219000572 putative NAD(P) binding site [chemical binding]; other site 483219000573 putative active site [active] 483219000574 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 483219000575 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 483219000576 active site 483219000577 purine riboside binding site [chemical binding]; other site 483219000578 PQQ-like domain; Region: PQQ_2; pfam13360 483219000579 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 483219000580 Trp docking motif [polypeptide binding]; other site 483219000581 active site 483219000582 PQQ-like domain; Region: PQQ_2; pfam13360 483219000583 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 483219000584 Part of AAA domain; Region: AAA_19; pfam13245 483219000585 Family description; Region: UvrD_C_2; pfam13538 483219000586 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 483219000587 CoenzymeA binding site [chemical binding]; other site 483219000588 subunit interaction site [polypeptide binding]; other site 483219000589 PHB binding site; other site 483219000590 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 483219000591 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 483219000592 DNA binding residues [nucleotide binding] 483219000593 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 483219000594 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 483219000595 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 483219000596 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 483219000597 active site 483219000598 metal binding site [ion binding]; metal-binding site 483219000599 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 483219000600 metal ion-dependent adhesion site (MIDAS); other site 483219000601 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 483219000602 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 483219000603 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 483219000604 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 483219000605 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 483219000606 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 483219000607 Active_site [active] 483219000608 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 483219000609 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 483219000610 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 483219000611 calcium binding site 2 [ion binding]; other site 483219000612 active site 483219000613 catalytic triad [active] 483219000614 calcium binding site 1 [ion binding]; other site 483219000615 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 483219000616 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 483219000617 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 483219000618 Sel1-like repeats; Region: SEL1; smart00671 483219000619 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 483219000620 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 483219000621 ATP binding site [chemical binding]; other site 483219000622 substrate interface [chemical binding]; other site 483219000623 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 483219000624 putative FMN binding site [chemical binding]; other site 483219000625 Cupin; Region: Cupin_6; pfam12852 483219000626 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 483219000627 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 483219000628 Homeodomain-like domain; Region: HTH_23; cl17451 483219000629 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 483219000630 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 483219000631 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 483219000632 active site 483219000633 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 483219000634 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219000635 Walker A motif; other site 483219000636 ATP binding site [chemical binding]; other site 483219000637 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 483219000638 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219000639 Walker A motif; other site 483219000640 ATP binding site [chemical binding]; other site 483219000641 Walker B motif; other site 483219000642 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 483219000643 peptide chain release factor 2; Provisional; Region: PRK05589 483219000644 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 483219000645 Putative catalytic NodB homology domain of uncharacterized prokaryotic polysaccharide deacetylases which consist of a 6-stranded beta/alpha barrel; Region: CE4_DAC_u1_6s; cd10970 483219000646 putative active site [active] 483219000647 putative metal binding site [ion binding]; other site 483219000648 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 483219000649 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219000650 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219000651 active site 483219000652 ATP binding site [chemical binding]; other site 483219000653 substrate binding site [chemical binding]; other site 483219000654 activation loop (A-loop); other site 483219000655 Tetratricopeptide repeat; Region: TPR_12; pfam13424 483219000656 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219000657 TPR motif; other site 483219000658 binding surface 483219000659 Tetratricopeptide repeat; Region: TPR_12; pfam13424 483219000660 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 483219000661 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 483219000662 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 483219000663 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 483219000664 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 483219000665 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 483219000666 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 483219000667 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 483219000668 FeS/SAM binding site; other site 483219000669 TRAM domain; Region: TRAM; pfam01938 483219000670 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 483219000671 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 483219000672 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 483219000673 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 483219000674 GTP1/OBG; Region: GTP1_OBG; pfam01018 483219000675 Obg GTPase; Region: Obg; cd01898 483219000676 G1 box; other site 483219000677 GTP/Mg2+ binding site [chemical binding]; other site 483219000678 Switch I region; other site 483219000679 G2 box; other site 483219000680 G3 box; other site 483219000681 Switch II region; other site 483219000682 G4 box; other site 483219000683 G5 box; other site 483219000684 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 483219000685 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 483219000686 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 483219000687 Protein kinase domain; Region: Pkinase; pfam00069 483219000688 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219000689 active site 483219000690 ATP binding site [chemical binding]; other site 483219000691 substrate binding site [chemical binding]; other site 483219000692 activation loop (A-loop); other site 483219000693 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 483219000694 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 483219000695 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 483219000696 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 483219000697 Predicted amidohydrolase [General function prediction only]; Region: COG0388 483219000698 active site 483219000699 catalytic triad [active] 483219000700 dimer interface [polypeptide binding]; other site 483219000701 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 483219000702 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 483219000703 GatB domain; Region: GatB_Yqey; smart00845 483219000704 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 483219000705 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 483219000706 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 483219000707 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 483219000708 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 483219000709 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 483219000710 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 483219000711 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 483219000712 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 483219000713 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 483219000714 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 483219000715 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 483219000716 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 483219000717 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 483219000718 potential protein location (hypothetical protein) that overlaps protein (membrane protein) 483219000719 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 483219000720 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 483219000721 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 483219000722 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 483219000723 FeS/SAM binding site; other site 483219000724 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 483219000725 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 483219000726 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 483219000727 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 483219000728 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 483219000729 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 483219000730 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 483219000731 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 483219000732 Myxococcales-restricted protein, TIGR02265 family; Region: Mxa_TIGR02265 483219000733 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 483219000734 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 483219000735 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219000736 Walker A motif; other site 483219000737 ATP binding site [chemical binding]; other site 483219000738 Walker B motif; other site 483219000739 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219000740 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 483219000741 Walker A motif; other site 483219000742 ATP binding site [chemical binding]; other site 483219000743 Walker B motif; other site 483219000744 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 483219000745 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 483219000746 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 483219000747 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 483219000748 hexamer interface [polypeptide binding]; other site 483219000749 RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468 483219000750 Walker A motif; other site 483219000751 ATP binding site [chemical binding]; other site 483219000752 Walker B motif; other site 483219000753 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 483219000754 competence damage-inducible protein A; Provisional; Region: PRK00549 483219000755 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 483219000756 putative MPT binding site; other site 483219000757 Competence-damaged protein; Region: CinA; pfam02464 483219000758 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 483219000759 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 483219000760 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 483219000761 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 483219000762 IHF dimer interface [polypeptide binding]; other site 483219000763 IHF - DNA interface [nucleotide binding]; other site 483219000764 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 483219000765 Peptidase family M23; Region: Peptidase_M23; pfam01551 483219000766 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 483219000767 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 483219000768 tetramer interface [polypeptide binding]; other site 483219000769 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483219000770 catalytic residue [active] 483219000771 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 483219000772 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 483219000773 minor groove reading motif; other site 483219000774 helix-hairpin-helix signature motif; other site 483219000775 substrate binding pocket [chemical binding]; other site 483219000776 active site 483219000777 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 483219000778 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 483219000779 active site 483219000780 catalytic residues [active] 483219000781 metal binding site [ion binding]; metal-binding site 483219000782 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219000783 active site 483219000784 phosphorylation site [posttranslational modification] 483219000785 intermolecular recognition site; other site 483219000786 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 483219000787 HSP70 interaction site [polypeptide binding]; other site 483219000788 primosome assembly protein PriA; Validated; Region: PRK05580 483219000789 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 483219000790 ATP binding site [chemical binding]; other site 483219000791 putative Mg++ binding site [ion binding]; other site 483219000792 helicase superfamily c-terminal domain; Region: HELICc; smart00490 483219000793 ATP-binding site [chemical binding]; other site 483219000794 glutathione S-transferase; Region: PLN02395 483219000795 GST_N family, Class Phi subfamily; composed of plant-specific class Phi GSTs and related fungal and bacterial proteins. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide...; Region: GST_N_Phi; cd03053 483219000796 C-terminal domain interface [polypeptide binding]; other site 483219000797 GSH binding site (G-site) [chemical binding]; other site 483219000798 dimer interface [polypeptide binding]; other site 483219000799 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 483219000800 N-terminal domain interface [polypeptide binding]; other site 483219000801 dimer interface [polypeptide binding]; other site 483219000802 substrate binding pocket (H-site) [chemical binding]; other site 483219000803 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 483219000804 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 483219000805 active site 483219000806 tetramer interface; other site 483219000807 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 483219000808 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 483219000809 active site 483219000810 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 483219000811 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 483219000812 active site 483219000813 Peptidase M3-like family, a zincin metallopeptidase, includes M3 and M32 families; Region: M3_like; cd06258 483219000814 active site 483219000815 Zn binding site [ion binding]; other site 483219000816 Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; cl01201 483219000817 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 483219000818 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 483219000819 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 483219000820 classical (c) SDRs; Region: SDR_c; cd05233 483219000821 NAD(P) binding site [chemical binding]; other site 483219000822 active site 483219000823 PQQ-like domain; Region: PQQ_2; pfam13360 483219000824 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 483219000825 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219000826 dimerization interface [polypeptide binding]; other site 483219000827 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 483219000828 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 483219000829 dimer interface [polypeptide binding]; other site 483219000830 putative CheW interface [polypeptide binding]; other site 483219000831 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 483219000832 Protein phosphatase 2C; Region: PP2C; pfam00481 483219000833 active site 483219000834 potential frameshift: common BLAST hit: gi|108756883|ref|YP_629664.1| class I/II aminotransferase 483219000835 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 483219000836 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 483219000837 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 483219000838 classical (c) SDRs; Region: SDR_c; cd05233 483219000839 NAD(P) binding site [chemical binding]; other site 483219000840 active site 483219000841 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 483219000842 Transcriptional regulator [Transcription]; Region: LysR; COG0583 483219000843 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 483219000844 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 483219000845 dimerization interface [polypeptide binding]; other site 483219000846 16S rRNA methyltransferase B; Provisional; Region: PRK14902 483219000847 NusB family; Region: NusB; pfam01029 483219000848 putative RNA binding site [nucleotide binding]; other site 483219000849 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 483219000850 Dehydroquinase class II; Region: DHquinase_II; pfam01220 483219000851 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cl00505 483219000852 trimer interface [polypeptide binding]; other site 483219000853 active site 483219000854 dimer interface [polypeptide binding]; other site 483219000855 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 483219000856 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 483219000857 putative active site [active] 483219000858 substrate binding site [chemical binding]; other site 483219000859 putative cosubstrate binding site; other site 483219000860 catalytic site [active] 483219000861 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 483219000862 substrate binding site [chemical binding]; other site 483219000863 HEAT repeats; Region: HEAT_2; pfam13646 483219000864 HEAT repeats; Region: HEAT_2; pfam13646 483219000865 HEAT repeats; Region: HEAT_2; pfam13646 483219000866 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 483219000867 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 483219000868 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 483219000869 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 483219000870 HSP90 family protein; Provisional; Region: PRK14083 483219000871 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219000872 ATP binding site [chemical binding]; other site 483219000873 Mg2+ binding site [ion binding]; other site 483219000874 G-X-G motif; other site 483219000875 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 483219000876 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 483219000877 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 483219000878 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 483219000879 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 483219000880 RNA binding site [nucleotide binding]; other site 483219000881 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 483219000882 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 483219000883 Coenzyme A binding pocket [chemical binding]; other site 483219000884 PhoD-like phosphatase; Region: PhoD; pfam09423 483219000885 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 483219000886 putative active site [active] 483219000887 putative metal binding site [ion binding]; other site 483219000888 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 483219000889 potential frameshift: common BLAST hit: gi|108759616|ref|YP_629645.1| recA protein 483219000890 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 483219000891 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 483219000892 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 483219000893 DNA binding residues [nucleotide binding] 483219000894 Putative zinc-finger; Region: zf-HC2; pfam13490 483219000895 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 483219000896 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 483219000897 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 483219000898 glutaminase active site [active] 483219000899 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 483219000900 dimer interface [polypeptide binding]; other site 483219000901 active site 483219000902 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 483219000903 dimer interface [polypeptide binding]; other site 483219000904 active site 483219000905 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 483219000906 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 483219000907 Substrate binding site; other site 483219000908 Mg++ binding site; other site 483219000909 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 483219000910 active site 483219000911 substrate binding site [chemical binding]; other site 483219000912 CoA binding site [chemical binding]; other site 483219000913 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 483219000914 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 483219000915 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 483219000916 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 483219000917 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 483219000918 Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin; Region: M3A_TOP; cd06455 483219000919 active site 483219000920 Zn binding site [ion binding]; other site 483219000921 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK12933 483219000922 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 483219000923 active site 483219000924 Response regulator receiver domain; Region: Response_reg; pfam00072 483219000925 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219000926 active site 483219000927 phosphorylation site [posttranslational modification] 483219000928 intermolecular recognition site; other site 483219000929 dimerization interface [polypeptide binding]; other site 483219000930 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 483219000931 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 483219000932 Walker A/P-loop; other site 483219000933 ATP binding site [chemical binding]; other site 483219000934 Q-loop/lid; other site 483219000935 ABC transporter signature motif; other site 483219000936 Walker B; other site 483219000937 D-loop; other site 483219000938 H-loop/switch region; other site 483219000939 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 483219000940 metal ion-dependent adhesion site (MIDAS); other site 483219000941 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 483219000942 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 483219000943 putative active site [active] 483219000944 Zn binding site [ion binding]; other site 483219000945 RF-1 domain; Region: RF-1; pfam00472 483219000946 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 483219000947 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 483219000948 HD domain; Region: HD_4; pfam13328 483219000949 aconitate hydratase; Validated; Region: PRK09277 483219000950 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 483219000951 substrate binding site [chemical binding]; other site 483219000952 ligand binding site [chemical binding]; other site 483219000953 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 483219000954 substrate binding site [chemical binding]; other site 483219000955 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 483219000956 PLD-like domain; Region: PLDc_2; pfam13091 483219000957 putative active site [active] 483219000958 catalytic site [active] 483219000959 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 483219000960 PLD-like domain; Region: PLDc_2; pfam13091 483219000961 putative active site [active] 483219000962 catalytic site [active] 483219000963 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 483219000964 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 483219000965 phosphopeptide binding site; other site 483219000966 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 483219000967 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 483219000968 phosphopeptide binding site; other site 483219000969 Predicted transcriptional regulator [Transcription]; Region: COG2378 483219000970 WYL domain; Region: WYL; pfam13280 483219000971 Predicted transcriptional regulator [Transcription]; Region: COG2378 483219000972 WYL domain; Region: WYL; pfam13280 483219000973 gamma-glutamyl kinase; Provisional; Region: PRK05429 483219000974 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 483219000975 nucleotide binding site [chemical binding]; other site 483219000976 homotetrameric interface [polypeptide binding]; other site 483219000977 putative phosphate binding site [ion binding]; other site 483219000978 putative allosteric binding site; other site 483219000979 PUA domain; Region: PUA; pfam01472 483219000980 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 483219000981 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 483219000982 HflX GTPase family; Region: HflX; cd01878 483219000983 G1 box; other site 483219000984 GTP/Mg2+ binding site [chemical binding]; other site 483219000985 Switch I region; other site 483219000986 G2 box; other site 483219000987 G3 box; other site 483219000988 Switch II region; other site 483219000989 G4 box; other site 483219000990 G5 box; other site 483219000991 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 483219000992 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 483219000993 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 483219000994 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 483219000995 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 483219000996 tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791 483219000997 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219000998 dimer interface [polypeptide binding]; other site 483219000999 phosphorylation site [posttranslational modification] 483219001000 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219001001 ATP binding site [chemical binding]; other site 483219001002 Mg2+ binding site [ion binding]; other site 483219001003 G-X-G motif; other site 483219001004 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 483219001005 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219001006 active site 483219001007 phosphorylation site [posttranslational modification] 483219001008 intermolecular recognition site; other site 483219001009 dimerization interface [polypeptide binding]; other site 483219001010 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 483219001011 DNA binding site [nucleotide binding] 483219001012 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219001013 S-adenosylmethionine binding site [chemical binding]; other site 483219001014 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 483219001015 FOG: WD40 repeat [General function prediction only]; Region: COG2319 483219001016 structural tetrad; other site 483219001017 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 483219001018 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 483219001019 phosphopeptide binding site; other site 483219001020 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219001021 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 483219001022 Walker A motif; other site 483219001023 ATP binding site [chemical binding]; other site 483219001024 Walker B motif; other site 483219001025 arginine finger; other site 483219001026 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 483219001027 Domain of unknown function (DUF3332); Region: DUF3332; pfam11810 483219001028 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 483219001029 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 483219001030 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 483219001031 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 483219001032 von Willebrand factor type A domain; Region: VWA_2; pfam13519 483219001033 metal ion-dependent adhesion site (MIDAS); other site 483219001034 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 483219001035 metal ion-dependent adhesion site (MIDAS); other site 483219001036 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 483219001037 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 483219001038 phosphopeptide binding site; other site 483219001039 Gram-negative bacterial tonB protein; Region: TonB; cl10048 483219001040 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 483219001041 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219001042 TPR motif; other site 483219001043 binding surface 483219001044 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 483219001045 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219001046 binding surface 483219001047 TPR motif; other site 483219001048 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219001049 binding surface 483219001050 TPR motif; other site 483219001051 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219001052 binding surface 483219001053 TPR motif; other site 483219001054 TPR repeat; Region: TPR_11; pfam13414 483219001055 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219001056 binding surface 483219001057 TPR motif; other site 483219001058 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 483219001059 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219001060 binding surface 483219001061 TPR motif; other site 483219001062 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 483219001063 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 483219001064 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 483219001065 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 483219001066 Walker A/P-loop; other site 483219001067 ATP binding site [chemical binding]; other site 483219001068 Q-loop/lid; other site 483219001069 ABC transporter signature motif; other site 483219001070 Walker B; other site 483219001071 D-loop; other site 483219001072 H-loop/switch region; other site 483219001073 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 483219001074 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 483219001075 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 483219001076 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 483219001077 intersubunit interface [polypeptide binding]; other site 483219001078 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 483219001079 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 483219001080 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 483219001081 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105 483219001082 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 483219001083 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 483219001084 N-terminal plug; other site 483219001085 ligand-binding site [chemical binding]; other site 483219001086 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 483219001087 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 483219001088 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 483219001089 Domain of unknown function DUF21; Region: DUF21; pfam01595 483219001090 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 483219001091 Transporter associated domain; Region: CorC_HlyC; smart01091 483219001092 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 483219001093 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219001094 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219001095 active site 483219001096 ATP binding site [chemical binding]; other site 483219001097 substrate binding site [chemical binding]; other site 483219001098 activation loop (A-loop); other site 483219001099 glycogen synthase; Provisional; Region: glgA; PRK00654 483219001100 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 483219001101 ADP-binding pocket [chemical binding]; other site 483219001102 homodimer interface [polypeptide binding]; other site 483219001103 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 483219001104 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 483219001105 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 483219001106 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 483219001107 NADP binding site [chemical binding]; other site 483219001108 homodimer interface [polypeptide binding]; other site 483219001109 active site 483219001110 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 483219001111 Histidine kinase; Region: His_kinase; pfam06580 483219001112 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 483219001113 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219001114 active site 483219001115 phosphorylation site [posttranslational modification] 483219001116 intermolecular recognition site; other site 483219001117 dimerization interface [polypeptide binding]; other site 483219001118 LytTr DNA-binding domain; Region: LytTR; smart00850 483219001119 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 483219001120 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 483219001121 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 483219001122 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 483219001123 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 483219001124 FeS/SAM binding site; other site 483219001125 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 483219001126 cyclase homology domain; Region: CHD; cd07302 483219001127 nucleotidyl binding site; other site 483219001128 metal binding site [ion binding]; metal-binding site 483219001129 dimer interface [polypeptide binding]; other site 483219001130 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 483219001131 putative active site [active] 483219001132 putative metal binding site [ion binding]; other site 483219001133 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 483219001134 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 483219001135 active site 483219001136 metal binding site [ion binding]; metal-binding site 483219001137 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 483219001138 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 483219001139 active site 483219001140 HIGH motif; other site 483219001141 nucleotide binding site [chemical binding]; other site 483219001142 active site 483219001143 KMSKS motif; other site 483219001144 Patatin-like phospholipase; Region: Patatin; pfam01734 483219001145 Predicted acetyltransferase [General function prediction only]; Region: COG3393 483219001146 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 483219001147 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 483219001148 active site 483219001149 dinuclear metal binding site [ion binding]; other site 483219001150 dimerization interface [polypeptide binding]; other site 483219001151 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 483219001152 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 483219001153 TrkA-C domain; Region: TrkA_C; pfam02080 483219001154 TrkA-C domain; Region: TrkA_C; pfam02080 483219001155 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 483219001156 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 483219001157 active site 483219001158 substrate-binding site [chemical binding]; other site 483219001159 metal-binding site [ion binding] 483219001160 GTP binding site [chemical binding]; other site 483219001161 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 483219001162 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 483219001163 aspartate aminotransferase; Provisional; Region: PRK07681 483219001164 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 483219001165 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483219001166 homodimer interface [polypeptide binding]; other site 483219001167 catalytic residue [active] 483219001168 AAA domain; Region: AAA_26; pfam13500 483219001169 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 483219001170 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 483219001171 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 483219001172 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 483219001173 catalytic residue [active] 483219001174 biotin synthase; Region: bioB; TIGR00433 483219001175 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 483219001176 FeS/SAM binding site; other site 483219001177 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 483219001178 DNA repair protein RadA; Provisional; Region: PRK11823 483219001179 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 483219001180 Walker A motif/ATP binding site; other site 483219001181 ATP binding site [chemical binding]; other site 483219001182 Walker B motif; other site 483219001183 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 483219001184 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219001185 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219001186 active site 483219001187 ATP binding site [chemical binding]; other site 483219001188 substrate binding site [chemical binding]; other site 483219001189 activation loop (A-loop); other site 483219001190 Transposase, Mutator family; Region: Transposase_mut; pfam00872 483219001191 MULE transposase domain; Region: MULE; pfam10551 483219001192 Transposase, Mutator family; Region: Transposase_mut; pfam00872 483219001193 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 483219001194 Interdomain contacts; other site 483219001195 Cytokine receptor motif; other site 483219001196 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 483219001197 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 483219001198 Glyco_18 domain; Region: Glyco_18; smart00636 483219001199 active site 483219001200 RibD C-terminal domain; Region: RibD_C; cl17279 483219001201 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 483219001202 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219001203 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 483219001204 dimerization interface [polypeptide binding]; other site 483219001205 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219001206 dimer interface [polypeptide binding]; other site 483219001207 phosphorylation site [posttranslational modification] 483219001208 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219001209 ATP binding site [chemical binding]; other site 483219001210 Mg2+ binding site [ion binding]; other site 483219001211 G-X-G motif; other site 483219001212 potential frameshift: common BLAST hit: gi|108760175|ref|YP_629507.1| methyl-accepting chemotaxis protein 483219001213 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 483219001214 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 483219001215 nudix motif; other site 483219001216 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 483219001217 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219001218 active site 483219001219 phosphorylation site [posttranslational modification] 483219001220 intermolecular recognition site; other site 483219001221 dimerization interface [polypeptide binding]; other site 483219001222 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219001223 Walker A motif; other site 483219001224 ATP binding site [chemical binding]; other site 483219001225 Walker B motif; other site 483219001226 arginine finger; other site 483219001227 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 483219001228 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219001229 TPR motif; other site 483219001230 TPR repeat; Region: TPR_11; pfam13414 483219001231 binding surface 483219001232 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 483219001233 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 483219001234 hypothetical protein; Reviewed; Region: PRK09588 483219001235 Uncharacterized protein family UPF0027; Region: UPF0027; cl17455 483219001236 phosphoglyceromutase; Provisional; Region: PRK05434 483219001237 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 483219001238 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 483219001239 transposase/IS protein; Provisional; Region: PRK09183 483219001240 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219001241 Walker A motif; other site 483219001242 ATP binding site [chemical binding]; other site 483219001243 Walker B motif; other site 483219001244 arginine finger; other site 483219001245 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 483219001246 Integrase core domain; Region: rve; pfam00665 483219001247 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 483219001248 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 483219001249 synthetase active site [active] 483219001250 NTP binding site [chemical binding]; other site 483219001251 metal binding site [ion binding]; metal-binding site 483219001252 Protein of unknown function (DUF2381); Region: DUF2381; pfam09544 483219001253 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219001254 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 483219001255 active site 483219001256 ATP binding site [chemical binding]; other site 483219001257 substrate binding site [chemical binding]; other site 483219001258 activation loop (A-loop); other site 483219001259 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 483219001260 sequence-specific DNA binding site [nucleotide binding]; other site 483219001261 salt bridge; other site 483219001262 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219001263 active site 483219001264 ATP binding site [chemical binding]; other site 483219001265 substrate binding site [chemical binding]; other site 483219001266 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 483219001267 activation loop (A-loop); other site 483219001268 activation loop (A-loop); other site 483219001269 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 483219001270 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 483219001271 Zn binding site [ion binding]; other site 483219001272 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 483219001273 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 483219001274 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 483219001275 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 483219001276 putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional; Region: PRK14501 483219001277 active site 483219001278 homotetramer interface [polypeptide binding]; other site 483219001279 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 483219001280 active site 483219001281 motif I; other site 483219001282 motif II; other site 483219001283 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219001284 dimerization interface [polypeptide binding]; other site 483219001285 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219001286 dimer interface [polypeptide binding]; other site 483219001287 phosphorylation site [posttranslational modification] 483219001288 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219001289 ATP binding site [chemical binding]; other site 483219001290 Mg2+ binding site [ion binding]; other site 483219001291 G-X-G motif; other site 483219001292 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 483219001293 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219001294 active site 483219001295 phosphorylation site [posttranslational modification] 483219001296 intermolecular recognition site; other site 483219001297 dimerization interface [polypeptide binding]; other site 483219001298 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219001299 Walker A motif; other site 483219001300 ATP binding site [chemical binding]; other site 483219001301 Walker B motif; other site 483219001302 arginine finger; other site 483219001303 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 483219001304 Haemolytic domain; Region: Haemolytic; cl00506 483219001305 Surface antigen; Region: Bac_surface_Ag; pfam01103 483219001306 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 483219001307 Sulfatase; Region: Sulfatase; pfam00884 483219001308 spermidine synthase; Provisional; Region: PRK03612 483219001309 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219001310 S-adenosylmethionine binding site [chemical binding]; other site 483219001311 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 483219001312 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 483219001313 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 483219001314 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; pfam02675 483219001315 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 483219001316 PGAP1-like protein; Region: PGAP1; pfam07819 483219001317 trigger factor; Region: tig; TIGR00115 483219001318 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 483219001319 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 483219001320 active site 483219001321 Serine hydrolase (FSH1); Region: FSH1; pfam03959 483219001322 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 483219001323 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 483219001324 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 483219001325 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 483219001326 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 483219001327 NAD(P) binding site [chemical binding]; other site 483219001328 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 483219001329 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 483219001330 active site 483219001331 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 483219001332 hydrophobic ligand binding site; other site 483219001333 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 483219001334 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219001335 active site 483219001336 phosphorylation site [posttranslational modification] 483219001337 intermolecular recognition site; other site 483219001338 dimerization interface [polypeptide binding]; other site 483219001339 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219001340 Walker A motif; other site 483219001341 ATP binding site [chemical binding]; other site 483219001342 Walker B motif; other site 483219001343 arginine finger; other site 483219001344 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 483219001345 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219001346 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219001347 dimer interface [polypeptide binding]; other site 483219001348 phosphorylation site [posttranslational modification] 483219001349 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219001350 ATP binding site [chemical binding]; other site 483219001351 Mg2+ binding site [ion binding]; other site 483219001352 G-X-G motif; other site 483219001353 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 483219001354 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 483219001355 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219001356 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219001357 active site 483219001358 ATP binding site [chemical binding]; other site 483219001359 substrate binding site [chemical binding]; other site 483219001360 activation loop (A-loop); other site 483219001361 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219001362 TPR motif; other site 483219001363 binding surface 483219001364 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 483219001365 Domain of Unknown Function with PDB structure (DUF3858); Region: DUF3858; pfam12970 483219001366 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 483219001367 catalytic nucleophile [active] 483219001368 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 483219001369 intracellular protease, PfpI family; Region: PfpI; TIGR01382 483219001370 proposed catalytic triad [active] 483219001371 conserved cys residue [active] 483219001372 probable FeS assembly SUF system protein SufT; Region: FeS_long_SufT; TIGR03406 483219001373 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 483219001374 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 483219001375 trimerization site [polypeptide binding]; other site 483219001376 active site 483219001377 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 483219001378 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 483219001379 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 483219001380 catalytic residue [active] 483219001381 FeS assembly protein SufD; Region: sufD; TIGR01981 483219001382 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 483219001383 FeS assembly ATPase SufC; Region: sufC; TIGR01978 483219001384 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 483219001385 Walker A/P-loop; other site 483219001386 ATP binding site [chemical binding]; other site 483219001387 Q-loop/lid; other site 483219001388 ABC transporter signature motif; other site 483219001389 Walker B; other site 483219001390 D-loop; other site 483219001391 H-loop/switch region; other site 483219001392 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 483219001393 putative ABC transporter; Region: ycf24; CHL00085 483219001394 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 483219001395 Transcriptional regulator; Region: Rrf2; pfam02082 483219001396 Transcriptional regulator; Region: Rrf2; cl17282 483219001397 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 483219001398 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 483219001399 putative ligand binding site [chemical binding]; other site 483219001400 TadE-like protein; Region: TadE; pfam07811 483219001401 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 483219001402 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219001403 binding surface 483219001404 TPR motif; other site 483219001405 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 483219001406 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 483219001407 HemN C-terminal domain; Region: HemN_C; pfam06969 483219001408 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 483219001409 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 483219001410 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 483219001411 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 483219001412 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 483219001413 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 483219001414 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 483219001415 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 483219001416 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219001417 S-adenosylmethionine binding site [chemical binding]; other site 483219001418 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 483219001419 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 483219001420 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 483219001421 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 483219001422 Protein of unknown function (DUF962); Region: DUF962; cl01879 483219001423 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 483219001424 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 483219001425 cyclase homology domain; Region: CHD; cd07302 483219001426 nucleotidyl binding site; other site 483219001427 metal binding site [ion binding]; metal-binding site 483219001428 dimer interface [polypeptide binding]; other site 483219001429 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 483219001430 RDD family; Region: RDD; pfam06271 483219001431 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 483219001432 HEAT repeats; Region: HEAT_2; pfam13646 483219001433 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219001434 dimer interface [polypeptide binding]; other site 483219001435 phosphorylation site [posttranslational modification] 483219001436 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219001437 ATP binding site [chemical binding]; other site 483219001438 Mg2+ binding site [ion binding]; other site 483219001439 G-X-G motif; other site 483219001440 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 483219001441 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219001442 active site 483219001443 phosphorylation site [posttranslational modification] 483219001444 intermolecular recognition site; other site 483219001445 dimerization interface [polypeptide binding]; other site 483219001446 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219001447 Walker A motif; other site 483219001448 ATP binding site [chemical binding]; other site 483219001449 Walker B motif; other site 483219001450 arginine finger; other site 483219001451 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 483219001452 Transcriptional regulator [Transcription]; Region: LysR; COG0583 483219001453 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 483219001454 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 483219001455 putative effector binding pocket; other site 483219001456 putative dimerization interface [polypeptide binding]; other site 483219001457 short chain dehydrogenase; Provisional; Region: PRK06180 483219001458 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 483219001459 NADP binding site [chemical binding]; other site 483219001460 active site 483219001461 steroid binding site; other site 483219001462 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 483219001463 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 483219001464 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 483219001465 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219001466 S-adenosylmethionine binding site [chemical binding]; other site 483219001467 PRMT5 arginine-N-methyltransferase; Region: PRMT5; cl17640 483219001468 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 483219001469 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219001470 Walker A/P-loop; other site 483219001471 ATP binding site [chemical binding]; other site 483219001472 Q-loop/lid; other site 483219001473 ABC transporter signature motif; other site 483219001474 Walker B; other site 483219001475 D-loop; other site 483219001476 H-loop/switch region; other site 483219001477 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 483219001478 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 483219001479 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 483219001480 catalytic residue [active] 483219001481 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 483219001482 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 483219001483 catalytic residue [active] 483219001484 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 483219001485 DUSAM domain; Region: TIGR02267 483219001486 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 483219001487 Peptidase family M50; Region: Peptidase_M50; pfam02163 483219001488 active site 483219001489 putative substrate binding region [chemical binding]; other site 483219001490 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 483219001491 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 483219001492 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 483219001493 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 483219001494 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 483219001495 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 483219001496 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 483219001497 ATP-grasp domain; Region: ATP-grasp_4; cl17255 483219001498 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 483219001499 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 483219001500 carboxyltransferase (CT) interaction site; other site 483219001501 biotinylation site [posttranslational modification]; other site 483219001502 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 483219001503 hypothetical protein; Provisional; Region: PRK10621 483219001504 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 483219001505 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 483219001506 HSP70 interaction site [polypeptide binding]; other site 483219001507 TPR repeat; Region: TPR_11; pfam13414 483219001508 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219001509 binding surface 483219001510 TPR motif; other site 483219001511 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 483219001512 TIGR02646 family protein; Region: TIGR02646 483219001513 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219001514 Q-loop/lid; other site 483219001515 ABC transporter signature motif; other site 483219001516 Walker B; other site 483219001517 D-loop; other site 483219001518 amidophosphoribosyltransferase; Provisional; Region: PRK09123 483219001519 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 483219001520 active site 483219001521 tetramer interface [polypeptide binding]; other site 483219001522 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 483219001523 active site 483219001524 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 483219001525 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 483219001526 active site 483219001527 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 483219001528 active site 483219001529 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 483219001530 homodimer interface [polypeptide binding]; other site 483219001531 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 483219001532 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 483219001533 Ligand binding site; other site 483219001534 oligomer interface; other site 483219001535 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 483219001536 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 483219001537 active site 483219001538 catalytic tetrad [active] 483219001539 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 483219001540 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 483219001541 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 483219001542 Walker A/P-loop; other site 483219001543 ATP binding site [chemical binding]; other site 483219001544 Q-loop/lid; other site 483219001545 ABC transporter signature motif; other site 483219001546 Walker B; other site 483219001547 D-loop; other site 483219001548 H-loop/switch region; other site 483219001549 CTP synthetase; Validated; Region: pyrG; PRK05380 483219001550 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 483219001551 Catalytic site [active] 483219001552 active site 483219001553 UTP binding site [chemical binding]; other site 483219001554 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 483219001555 active site 483219001556 putative oxyanion hole; other site 483219001557 catalytic triad [active] 483219001558 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 483219001559 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 483219001560 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 483219001561 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 483219001562 DNA binding residues [nucleotide binding] 483219001563 Response regulator receiver domain; Region: Response_reg; pfam00072 483219001564 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219001565 active site 483219001566 phosphorylation site [posttranslational modification] 483219001567 intermolecular recognition site; other site 483219001568 dimerization interface [polypeptide binding]; other site 483219001569 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 483219001570 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 483219001571 putative dimer interface [polypeptide binding]; other site 483219001572 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 483219001573 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 483219001574 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 483219001575 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 483219001576 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 483219001577 phosphoserine phosphatase SerB; Region: serB; TIGR00338 483219001578 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 483219001579 motif II; other site 483219001580 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219001581 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219001582 active site 483219001583 ATP binding site [chemical binding]; other site 483219001584 substrate binding site [chemical binding]; other site 483219001585 activation loop (A-loop); other site 483219001586 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 483219001587 Myxococcus xanthus paralogous domain TIGR02266; Region: gmx_TIGR02266 483219001588 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 483219001589 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219001590 active site 483219001591 phosphorylation site [posttranslational modification] 483219001592 intermolecular recognition site; other site 483219001593 dimerization interface [polypeptide binding]; other site 483219001594 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 483219001595 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 483219001596 putative dimer interface [polypeptide binding]; other site 483219001597 [2Fe-2S] cluster binding site [ion binding]; other site 483219001598 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 483219001599 SLBB domain; Region: SLBB; pfam10531 483219001600 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 483219001601 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 483219001602 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 483219001603 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 483219001604 proton-translocating NADH-quinone oxidoreductase, chain L; Region: NDH_I_L; TIGR01974 483219001605 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 483219001606 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 483219001607 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 483219001608 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 483219001609 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 483219001610 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 483219001611 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 483219001612 Coenzyme A binding pocket [chemical binding]; other site 483219001613 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 483219001614 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219001615 active site 483219001616 phosphorylation site [posttranslational modification] 483219001617 intermolecular recognition site; other site 483219001618 dimerization interface [polypeptide binding]; other site 483219001619 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219001620 Walker A motif; other site 483219001621 ATP binding site [chemical binding]; other site 483219001622 Walker B motif; other site 483219001623 arginine finger; other site 483219001624 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 483219001625 PAS fold; Region: PAS; pfam00989 483219001626 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219001627 putative active site [active] 483219001628 heme pocket [chemical binding]; other site 483219001629 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 483219001630 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 483219001631 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219001632 dimer interface [polypeptide binding]; other site 483219001633 phosphorylation site [posttranslational modification] 483219001634 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219001635 ATP binding site [chemical binding]; other site 483219001636 Mg2+ binding site [ion binding]; other site 483219001637 G-X-G motif; other site 483219001638 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 483219001639 GTPases - translation elongation factors [Translation, ribosomal structure and biogenesis]; Region: TufB; COG0050 483219001640 G1 box; other site 483219001641 GTP/Mg2+ binding site [chemical binding]; other site 483219001642 G2 box; other site 483219001643 Switch I region; other site 483219001644 G3 box; other site 483219001645 Switch II region; other site 483219001646 G4 box; other site 483219001647 G5 box; other site 483219001648 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 483219001649 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 483219001650 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 483219001651 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 483219001652 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 483219001653 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 483219001654 active site 483219001655 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 483219001656 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 483219001657 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 483219001658 NAD binding site [chemical binding]; other site 483219001659 Phe binding site; other site 483219001660 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 483219001661 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 483219001662 dimerization interface [polypeptide binding]; other site 483219001663 domain crossover interface; other site 483219001664 redox-dependent activation switch; other site 483219001665 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 483219001666 Iron-sulfur protein interface; other site 483219001667 proximal heme binding site [chemical binding]; other site 483219001668 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 483219001669 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 483219001670 dimer interface [polypeptide binding]; other site 483219001671 ssDNA binding site [nucleotide binding]; other site 483219001672 tetramer (dimer of dimers) interface [polypeptide binding]; other site 483219001673 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 483219001674 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 483219001675 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 483219001676 putative active site [active] 483219001677 dimerization interface [polypeptide binding]; other site 483219001678 putative tRNAtyr binding site [nucleotide binding]; other site 483219001679 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 483219001680 active site 483219001681 phosphorylation site [posttranslational modification] 483219001682 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 483219001683 30S subunit binding site; other site 483219001684 short chain dehydrogenase; Provisional; Region: PRK06701 483219001685 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 483219001686 NAD binding site [chemical binding]; other site 483219001687 metal binding site [ion binding]; metal-binding site 483219001688 active site 483219001689 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 483219001690 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 483219001691 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 483219001692 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 483219001693 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 483219001694 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 483219001695 Walker A/P-loop; other site 483219001696 ATP binding site [chemical binding]; other site 483219001697 Q-loop/lid; other site 483219001698 ABC transporter signature motif; other site 483219001699 Walker B; other site 483219001700 D-loop; other site 483219001701 H-loop/switch region; other site 483219001702 OstA-like protein; Region: OstA; pfam03968 483219001703 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 483219001704 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 483219001705 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 483219001706 putative acyl-acceptor binding pocket; other site 483219001707 succinylarginine dihydrolase; Provisional; Region: PRK13281 483219001708 Protein of unknown function (Gmx_para_CXXCG); Region: Gmx_para_CXXCG; cl15282 483219001709 Predicted lipoprotein of unknown function (DUF2380); Region: DUF2380; cl15289 483219001710 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 483219001711 putative deacylase active site [active] 483219001712 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219001713 TPR motif; other site 483219001714 binding surface 483219001715 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 483219001716 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 483219001717 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 483219001718 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 483219001719 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 483219001720 Family description; Region: VCBS; pfam13517 483219001721 Family description; Region: VCBS; pfam13517 483219001722 Family description; Region: VCBS; pfam13517 483219001723 Family description; Region: VCBS; pfam13517 483219001724 CARDB; Region: CARDB; pfam07705 483219001725 HYR domain; Region: HYR; pfam02494 483219001726 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 483219001727 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219001728 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 483219001729 Walker A motif; other site 483219001730 ATP binding site [chemical binding]; other site 483219001731 Walker B motif; other site 483219001732 arginine finger; other site 483219001733 Winged helix-turn helix; Region: HTH_29; pfam13551 483219001734 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 483219001735 Integrase core domain; Region: rve; pfam00665 483219001736 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219001737 active site 483219001738 ATP binding site [chemical binding]; other site 483219001739 substrate binding site [chemical binding]; other site 483219001740 activation loop (A-loop); other site 483219001741 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219001742 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219001743 active site 483219001744 ATP binding site [chemical binding]; other site 483219001745 substrate binding site [chemical binding]; other site 483219001746 activation loop (A-loop); other site 483219001747 Protein of unknown function (DUF2381); Region: DUF2381; pfam09544 483219001748 Protein of unknown function (DUF2379); Region: DUF2379; pfam09543 483219001749 Protein of unknown function (DUF2381); Region: DUF2381; cl15442 483219001750 DUSAM domain; Region: TIGR02267 483219001751 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 483219001752 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 483219001753 Mg++ binding site [ion binding]; other site 483219001754 putative catalytic motif [active] 483219001755 substrate binding site [chemical binding]; other site 483219001756 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 483219001757 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 483219001758 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 483219001759 Sulfatase; Region: Sulfatase; pfam00884 483219001760 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 483219001761 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 483219001762 Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075 483219001763 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 483219001764 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 483219001765 active site 483219001766 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 483219001767 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 483219001768 Probable Catalytic site; other site 483219001769 metal-binding site 483219001770 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 483219001771 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 483219001772 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219001773 S-adenosylmethionine binding site [chemical binding]; other site 483219001774 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 483219001775 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 483219001776 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 483219001777 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 483219001778 Glycosyl transferase 4-like domain; Region: Glyco_trans_4_4; pfam13579 483219001779 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 483219001780 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 483219001781 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 483219001782 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 483219001783 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 483219001784 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 483219001785 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 483219001786 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 483219001787 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 483219001788 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 483219001789 putative ADP-binding pocket [chemical binding]; other site 483219001790 chain length determinant protein EpsF; Region: EpsF; TIGR03017 483219001791 Chain length determinant protein; Region: Wzz; cl15801 483219001792 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 483219001793 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 483219001794 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 483219001795 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 483219001796 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 483219001797 active site 483219001798 Methyltransferase domain; Region: Methyltransf_23; pfam13489 483219001799 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219001800 S-adenosylmethionine binding site [chemical binding]; other site 483219001801 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 483219001802 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 483219001803 Cytochrome c; Region: Cytochrom_C; pfam00034 483219001804 PAS domain; Region: PAS; smart00091 483219001805 PAS fold; Region: PAS_4; pfam08448 483219001806 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219001807 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219001808 dimer interface [polypeptide binding]; other site 483219001809 phosphorylation site [posttranslational modification] 483219001810 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219001811 ATP binding site [chemical binding]; other site 483219001812 Mg2+ binding site [ion binding]; other site 483219001813 G-X-G motif; other site 483219001814 transcription-repair coupling factor (mfd); Region: mfd; TIGR00580 483219001815 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 483219001816 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 483219001817 ATP binding site [chemical binding]; other site 483219001818 putative Mg++ binding site [ion binding]; other site 483219001819 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 483219001820 nucleotide binding region [chemical binding]; other site 483219001821 ATP-binding site [chemical binding]; other site 483219001822 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 483219001823 acetylornithine deacetylase (ArgE); Region: AcOrn-deacetyl; TIGR01892 483219001824 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 483219001825 metal binding site [ion binding]; metal-binding site 483219001826 putative dimer interface [polypeptide binding]; other site 483219001827 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 483219001828 active site 483219001829 Protein of unknown function (DUF1688); Region: DUF1688; pfam07958 483219001830 formiminoglutamate deiminase; Region: hutF; TIGR02022 483219001831 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 483219001832 active site 483219001833 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 483219001834 dinuclear metal binding motif [ion binding]; other site 483219001835 FG-GAP repeat; Region: FG-GAP; cl15299 483219001836 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 483219001837 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 483219001838 Protein of unknown function (DUF420); Region: DUF420; pfam04238 483219001839 Response regulator receiver domain; Region: Response_reg; pfam00072 483219001840 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219001841 active site 483219001842 phosphorylation site [posttranslational modification] 483219001843 intermolecular recognition site; other site 483219001844 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219001845 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219001846 dimer interface [polypeptide binding]; other site 483219001847 phosphorylation site [posttranslational modification] 483219001848 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219001849 ATP binding site [chemical binding]; other site 483219001850 Mg2+ binding site [ion binding]; other site 483219001851 G-X-G motif; other site 483219001852 Response regulator receiver domain; Region: Response_reg; pfam00072 483219001853 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219001854 active site 483219001855 phosphorylation site [posttranslational modification] 483219001856 intermolecular recognition site; other site 483219001857 dimerization interface [polypeptide binding]; other site 483219001858 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 483219001859 GAF domain; Region: GAF; pfam01590 483219001860 Phytochrome region; Region: PHY; pfam00360 483219001861 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219001862 dimer interface [polypeptide binding]; other site 483219001863 phosphorylation site [posttranslational modification] 483219001864 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219001865 ATP binding site [chemical binding]; other site 483219001866 Mg2+ binding site [ion binding]; other site 483219001867 G-X-G motif; other site 483219001868 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 483219001869 heme binding pocket [chemical binding]; other site 483219001870 heme ligand [chemical binding]; other site 483219001871 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 483219001872 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 483219001873 active site 483219001874 catalytic triad [active] 483219001875 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 483219001876 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 483219001877 ATP binding site [chemical binding]; other site 483219001878 putative Mg++ binding site [ion binding]; other site 483219001879 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 483219001880 nucleotide binding region [chemical binding]; other site 483219001881 ATP-binding site [chemical binding]; other site 483219001882 DEAD/H associated; Region: DEAD_assoc; pfam08494 483219001883 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 483219001884 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 483219001885 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 483219001886 Walker A/P-loop; other site 483219001887 ATP binding site [chemical binding]; other site 483219001888 Q-loop/lid; other site 483219001889 ABC transporter signature motif; other site 483219001890 Walker B; other site 483219001891 D-loop; other site 483219001892 H-loop/switch region; other site 483219001893 Myxococcales-restricted protein, TIGR02265 family; Region: Mxa_TIGR02265 483219001894 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 483219001895 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219001896 active site 483219001897 phosphorylation site [posttranslational modification] 483219001898 intermolecular recognition site; other site 483219001899 dimerization interface [polypeptide binding]; other site 483219001900 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 483219001901 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219001902 dimer interface [polypeptide binding]; other site 483219001903 phosphorylation site [posttranslational modification] 483219001904 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219001905 ATP binding site [chemical binding]; other site 483219001906 Mg2+ binding site [ion binding]; other site 483219001907 G-X-G motif; other site 483219001908 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 483219001909 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 483219001910 dimer interface [polypeptide binding]; other site 483219001911 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483219001912 catalytic residue [active] 483219001913 Outer membrane efflux protein; Region: OEP; pfam02321 483219001914 Outer membrane efflux protein; Region: OEP; pfam02321 483219001915 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 483219001916 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 483219001917 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 483219001918 HlyD family secretion protein; Region: HlyD_3; pfam13437 483219001919 HlyD family secretion protein; Region: HlyD_3; pfam13437 483219001920 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 483219001921 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 483219001922 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 483219001923 iron-sulfur cluster [ion binding]; other site 483219001924 [2Fe-2S] cluster binding site [ion binding]; other site 483219001925 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 483219001926 hydrophobic ligand binding site; other site 483219001927 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 483219001928 dimerization interface [polypeptide binding]; other site 483219001929 Uncharacterized conserved protein [Function unknown]; Region: COG3350 483219001930 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 483219001931 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 483219001932 Soluble P-type ATPase [General function prediction only]; Region: COG4087 483219001933 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 483219001934 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 483219001935 SnoaL-like domain; Region: SnoaL_2; pfam12680 483219001936 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 483219001937 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 483219001938 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 483219001939 dimer interface [polypeptide binding]; other site 483219001940 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 483219001941 AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052 483219001942 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 483219001943 GIY-YIG motif/motif A; other site 483219001944 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 483219001945 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 483219001946 DNA binding residues [nucleotide binding] 483219001947 AAK_AK-HSDH-like: Amino Acid Kinase Superfamily (AAK), AK-HSDH-like; this family includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK- homoserine dehydrogenase (HSDH). These aspartokinases are found in such...; Region: AAK_AK-HSDH-like; cd04243 483219001948 aspartate kinase; Validated; Region: PRK08373 483219001949 putative catalytic residues [active] 483219001950 nucleotide binding site [chemical binding]; other site 483219001951 aspartate binding site [chemical binding]; other site 483219001952 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 483219001953 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 483219001954 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 483219001955 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 483219001956 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 483219001957 cystathionine gamma-synthase; Reviewed; Region: PRK08247 483219001958 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 483219001959 homodimer interface [polypeptide binding]; other site 483219001960 substrate-cofactor binding pocket; other site 483219001961 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483219001962 catalytic residue [active] 483219001963 cystathionine beta-lyase; Provisional; Region: PRK07671 483219001964 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 483219001965 homodimer interface [polypeptide binding]; other site 483219001966 substrate-cofactor binding pocket; other site 483219001967 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483219001968 catalytic residue [active] 483219001969 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 483219001970 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 483219001971 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241 483219001972 putative active site [active] 483219001973 Zn binding site [ion binding]; other site 483219001974 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 483219001975 metal ion-dependent adhesion site (MIDAS); other site 483219001976 PilZ domain; Region: PilZ; cl01260 483219001977 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219001978 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219001979 active site 483219001980 ATP binding site [chemical binding]; other site 483219001981 substrate binding site [chemical binding]; other site 483219001982 activation loop (A-loop); other site 483219001983 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219001984 Walker A/P-loop; other site 483219001985 ATP binding site [chemical binding]; other site 483219001986 Q-loop/lid; other site 483219001987 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219001988 ABC transporter signature motif; other site 483219001989 Walker B; other site 483219001990 D-loop; other site 483219001991 H-loop/switch region; other site 483219001992 exonuclease subunit SbcD; Provisional; Region: PRK10966 483219001993 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 483219001994 active site 483219001995 metal binding site [ion binding]; metal-binding site 483219001996 DNA binding site [nucleotide binding] 483219001997 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 483219001998 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 483219001999 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 483219002000 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 483219002001 putative acyl-acceptor binding pocket; other site 483219002002 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 483219002003 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 483219002004 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 483219002005 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 483219002006 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 483219002007 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 483219002008 putative active site [active] 483219002009 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 483219002010 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 483219002011 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 483219002012 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 483219002013 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 483219002014 active site 483219002015 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 483219002016 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 483219002017 active site 483219002018 Putative zinc-finger; Region: zf-HC2; pfam13490 483219002019 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219002020 binding surface 483219002021 TPR motif; other site 483219002022 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 483219002023 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 483219002024 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 483219002025 DNA binding residues [nucleotide binding] 483219002026 Cupin-like domain; Region: Cupin_8; pfam13621 483219002027 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219002028 binding surface 483219002029 TPR motif; other site 483219002030 TPR repeat; Region: TPR_11; pfam13414 483219002031 CHAT domain; Region: CHAT; cl17868 483219002032 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 483219002033 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 483219002034 MarR family; Region: MarR; pfam01047 483219002035 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 483219002036 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219002037 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219002038 dimerization interface [polypeptide binding]; other site 483219002039 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219002040 dimer interface [polypeptide binding]; other site 483219002041 phosphorylation site [posttranslational modification] 483219002042 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219002043 ATP binding site [chemical binding]; other site 483219002044 Mg2+ binding site [ion binding]; other site 483219002045 G-X-G motif; other site 483219002046 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 483219002047 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219002048 active site 483219002049 phosphorylation site [posttranslational modification] 483219002050 intermolecular recognition site; other site 483219002051 dimerization interface [polypeptide binding]; other site 483219002052 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219002053 Walker A motif; other site 483219002054 ATP binding site [chemical binding]; other site 483219002055 Walker B motif; other site 483219002056 arginine finger; other site 483219002057 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 483219002058 Glutamine cyclotransferase; Region: Glu_cyclase_2; pfam05096 483219002059 Response regulator receiver domain; Region: Response_reg; pfam00072 483219002060 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219002061 active site 483219002062 phosphorylation site [posttranslational modification] 483219002063 intermolecular recognition site; other site 483219002064 dimerization interface [polypeptide binding]; other site 483219002065 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 483219002066 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 483219002067 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 483219002068 protein binding site [polypeptide binding]; other site 483219002069 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 483219002070 Protein kinase domain; Region: Pkinase; pfam00069 483219002071 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219002072 active site 483219002073 ATP binding site [chemical binding]; other site 483219002074 substrate binding site [chemical binding]; other site 483219002075 activation loop (A-loop); other site 483219002076 oligopeptide transporter, OPT superfamily; Region: OPT_sfam; TIGR00728 483219002077 OPT oligopeptide transporter protein; Region: OPT; pfam03169 483219002078 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 483219002079 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 483219002080 phosphopeptide binding site; other site 483219002081 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219002082 PAS fold; Region: PAS_3; pfam08447 483219002083 putative active site [active] 483219002084 heme pocket [chemical binding]; other site 483219002085 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 483219002086 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219002087 putative active site [active] 483219002088 heme pocket [chemical binding]; other site 483219002089 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219002090 dimer interface [polypeptide binding]; other site 483219002091 phosphorylation site [posttranslational modification] 483219002092 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219002093 ATP binding site [chemical binding]; other site 483219002094 Mg2+ binding site [ion binding]; other site 483219002095 G-X-G motif; other site 483219002096 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 483219002097 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219002098 active site 483219002099 phosphorylation site [posttranslational modification] 483219002100 intermolecular recognition site; other site 483219002101 dimerization interface [polypeptide binding]; other site 483219002102 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219002103 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219002104 active site 483219002105 ATP binding site [chemical binding]; other site 483219002106 substrate binding site [chemical binding]; other site 483219002107 activation loop (A-loop); other site 483219002108 GLTT repeat (6 copies); Region: GLTT; pfam01744 483219002109 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219002110 dimer interface [polypeptide binding]; other site 483219002111 phosphorylation site [posttranslational modification] 483219002112 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219002113 ATP binding site [chemical binding]; other site 483219002114 Mg2+ binding site [ion binding]; other site 483219002115 G-X-G motif; other site 483219002116 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 483219002117 potential frameshift: common BLAST hit: gi|186682706|ref|YP_001865902.1| beta-lactamase domain-containing protein 483219002118 potential protein location (hypothetical protein) that overlaps protein (hypothetical protein) 483219002119 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 483219002120 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 483219002121 classical (c) SDRs; Region: SDR_c; cd05233 483219002122 NAD(P) binding site [chemical binding]; other site 483219002123 active site 483219002124 Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002 483219002125 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 483219002126 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 483219002127 NAD binding site [chemical binding]; other site 483219002128 catalytic residues [active] 483219002129 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 483219002130 homotrimer interaction site [polypeptide binding]; other site 483219002131 putative active site [active] 483219002132 3-hydroxyanthranilic acid dioxygenase; Region: 3-HAO; cl17399 483219002133 active site 483219002134 Amidohydrolase; Region: Amidohydro_2; pfam04909 483219002135 kynureninase; Region: kynureninase; TIGR01814 483219002136 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 483219002137 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 483219002138 catalytic residue [active] 483219002139 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 483219002140 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 483219002141 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 483219002142 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 483219002143 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 483219002144 putative NAD(P) binding site [chemical binding]; other site 483219002145 putative active site [active] 483219002146 Fic family protein [Function unknown]; Region: COG3177 483219002147 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 483219002148 Fic/DOC family; Region: Fic; pfam02661 483219002149 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 483219002150 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 483219002151 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 483219002152 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 483219002153 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 483219002154 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 483219002155 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 483219002156 FHA domain; Region: FHA; pfam00498 483219002157 phosphopeptide binding site; other site 483219002158 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219002159 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 483219002160 Walker A motif; other site 483219002161 ATP binding site [chemical binding]; other site 483219002162 Walker B motif; other site 483219002163 arginine finger; other site 483219002164 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 483219002165 active site 483219002166 ATP binding site [chemical binding]; other site 483219002167 activation loop (A-loop); other site 483219002168 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 483219002169 AAA ATPase domain; Region: AAA_16; pfam13191 483219002170 Uncharacterized conserved protein [Function unknown]; Region: COG1262 483219002171 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 483219002172 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 483219002173 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 483219002174 DNA binding residues [nucleotide binding] 483219002175 B12 binding domain; Region: B12-binding_2; pfam02607 483219002176 B12 binding domain; Region: B12-binding; pfam02310 483219002177 B12 binding site [chemical binding]; other site 483219002178 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 483219002179 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 483219002180 DNA binding residues [nucleotide binding] 483219002181 B12 binding domain; Region: B12-binding_2; pfam02607 483219002182 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065 483219002183 B12 binding site [chemical binding]; other site 483219002184 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551 483219002185 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 483219002186 putative acyl-acceptor binding pocket; other site 483219002187 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 483219002188 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 483219002189 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 483219002190 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 483219002191 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 483219002192 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 483219002193 active site lid residues [active] 483219002194 substrate binding pocket [chemical binding]; other site 483219002195 catalytic residues [active] 483219002196 substrate-Mg2+ binding site; other site 483219002197 aspartate-rich region 1; other site 483219002198 aspartate-rich region 2; other site 483219002199 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 483219002200 phytoene desaturase; Region: crtI_fam; TIGR02734 483219002201 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 483219002202 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 483219002203 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 483219002204 substrate binding pocket [chemical binding]; other site 483219002205 chain length determination region; other site 483219002206 substrate-Mg2+ binding site; other site 483219002207 catalytic residues [active] 483219002208 aspartate-rich region 1; other site 483219002209 active site lid residues [active] 483219002210 aspartate-rich region 2; other site 483219002211 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 483219002212 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; cl17398 483219002213 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 483219002214 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 483219002215 putative NAD(P) binding site [chemical binding]; other site 483219002216 putative active site [active] 483219002217 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 483219002218 glycogen binding site [chemical binding]; other site 483219002219 Putative esterase; Region: Esterase; pfam00756 483219002220 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 483219002221 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 483219002222 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219002223 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 483219002224 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219002225 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 483219002226 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219002227 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 483219002228 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219002229 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219002230 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219002231 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 483219002232 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219002233 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219002234 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219002235 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 483219002236 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219002237 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 483219002238 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219002239 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219002240 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219002241 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 483219002242 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219002243 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219002244 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219002245 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219002246 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219002247 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 483219002248 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219002249 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219002250 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219002251 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219002252 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219002253 phosphodiesterase YaeI; Provisional; Region: PRK11340 483219002254 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 483219002255 putative active site [active] 483219002256 putative metal binding site [ion binding]; other site 483219002257 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 483219002258 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 483219002259 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 483219002260 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 483219002261 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 483219002262 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 483219002263 Amidohydrolase; Region: Amidohydro_4; pfam13147 483219002264 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 483219002265 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 483219002266 Lamin Tail Domain; Region: LTD; pfam00932 483219002267 ATP-grasp domain; Region: ATP-grasp_4; cl17255 483219002268 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 483219002269 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 483219002270 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 483219002271 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 483219002272 phosphopeptide binding site; other site 483219002273 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219002274 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219002275 active site 483219002276 ATP binding site [chemical binding]; other site 483219002277 substrate binding site [chemical binding]; other site 483219002278 activation loop (A-loop); other site 483219002279 PEGA domain; Region: PEGA; pfam08308 483219002280 Protein required for attachment to host cells; Region: Host_attach; pfam10116 483219002281 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 483219002282 HAMP domain; Region: HAMP; pfam00672 483219002283 dimerization interface [polypeptide binding]; other site 483219002284 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 483219002285 dimer interface [polypeptide binding]; other site 483219002286 putative CheW interface [polypeptide binding]; other site 483219002287 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 483219002288 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 483219002289 motif II; other site 483219002290 potential frameshift: common BLAST hit: gi|108756891|ref|YP_629137.1| group 2 family glycosyl transferase 483219002291 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 483219002292 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 483219002293 putative C-terminal domain interface [polypeptide binding]; other site 483219002294 putative GSH binding site (G-site) [chemical binding]; other site 483219002295 putative dimer interface [polypeptide binding]; other site 483219002296 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 483219002297 putative substrate binding pocket (H-site) [chemical binding]; other site 483219002298 putative N-terminal domain interface [polypeptide binding]; other site 483219002299 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 483219002300 cyclase homology domain; Region: CHD; cd07302 483219002301 nucleotidyl binding site; other site 483219002302 metal binding site [ion binding]; metal-binding site 483219002303 dimer interface [polypeptide binding]; other site 483219002304 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219002305 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219002306 active site 483219002307 ATP binding site [chemical binding]; other site 483219002308 substrate binding site [chemical binding]; other site 483219002309 activation loop (A-loop); other site 483219002310 Peptidase S46; Region: Peptidase_S46; pfam10459 483219002311 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 483219002312 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 483219002313 Gram-negative bacterial tonB protein; Region: TonB; cl10048 483219002314 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 483219002315 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219002316 Walker A motif; other site 483219002317 ATP binding site [chemical binding]; other site 483219002318 Walker B motif; other site 483219002319 arginine finger; other site 483219002320 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219002321 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219002322 active site 483219002323 ATP binding site [chemical binding]; other site 483219002324 substrate binding site [chemical binding]; other site 483219002325 activation loop (A-loop); other site 483219002326 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219002327 binding surface 483219002328 TPR motif; other site 483219002329 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 483219002330 CoenzymeA binding site [chemical binding]; other site 483219002331 subunit interaction site [polypeptide binding]; other site 483219002332 PHB binding site; other site 483219002333 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 483219002334 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 483219002335 dimerization interface [polypeptide binding]; other site 483219002336 DPS ferroxidase diiron center [ion binding]; other site 483219002337 ion pore; other site 483219002338 short chain dehydrogenase; Provisional; Region: PRK06197 483219002339 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 483219002340 putative NAD(P) binding site [chemical binding]; other site 483219002341 active site 483219002342 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 483219002343 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 483219002344 C-terminal domain interface [polypeptide binding]; other site 483219002345 GSH binding site (G-site) [chemical binding]; other site 483219002346 dimer interface [polypeptide binding]; other site 483219002347 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 483219002348 N-terminal domain interface [polypeptide binding]; other site 483219002349 dimer interface [polypeptide binding]; other site 483219002350 substrate binding pocket (H-site) [chemical binding]; other site 483219002351 Uncharacterized conserved protein [Function unknown]; Region: COG0397 483219002352 hypothetical protein; Validated; Region: PRK00029 483219002353 Inorganic pyrophosphatase; Region: Pyrophosphatase; pfam00719 483219002354 dimer interface [polypeptide binding]; other site 483219002355 substrate binding site [chemical binding]; other site 483219002356 metal binding sites [ion binding]; metal-binding site 483219002357 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 483219002358 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 483219002359 putative chaperone; Provisional; Region: PRK11678 483219002360 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 483219002361 nucleotide binding site [chemical binding]; other site 483219002362 putative NEF/HSP70 interaction site [polypeptide binding]; other site 483219002363 SBD interface [polypeptide binding]; other site 483219002364 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 483219002365 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 483219002366 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 483219002367 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 483219002368 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 483219002369 ligand binding site [chemical binding]; other site 483219002370 Protein of unknown function (Gmx_para_CXXCG); Region: Gmx_para_CXXCG; cl15282 483219002371 Predicted lipoprotein of unknown function (DUF2380); Region: DUF2380; pfam09533 483219002372 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 483219002373 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 483219002374 dimer interface [polypeptide binding]; other site 483219002375 active site 483219002376 CoA binding pocket [chemical binding]; other site 483219002377 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 483219002378 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 483219002379 putative [Fe4-S4] binding site [ion binding]; other site 483219002380 putative molybdopterin cofactor binding site [chemical binding]; other site 483219002381 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 483219002382 putative molybdopterin cofactor binding site; other site 483219002383 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 483219002384 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 483219002385 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 483219002386 active site 483219002387 ATP binding site [chemical binding]; other site 483219002388 substrate binding site [chemical binding]; other site 483219002389 activation loop (A-loop); other site 483219002390 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219002391 active site 483219002392 ATP binding site [chemical binding]; other site 483219002393 substrate binding site [chemical binding]; other site 483219002394 activation loop (A-loop); other site 483219002395 Protein of unknown function (DUF2381); Region: DUF2381; pfam09544 483219002396 PilZ domain; Region: PilZ; pfam07238 483219002397 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 483219002398 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 483219002399 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 483219002400 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 483219002401 UreD urease accessory protein; Region: UreD; pfam01774 483219002402 bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192 483219002403 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 483219002404 alpha-gamma subunit interface [polypeptide binding]; other site 483219002405 beta-gamma subunit interface [polypeptide binding]; other site 483219002406 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 483219002407 alpha-beta subunit interface [polypeptide binding]; other site 483219002408 urease subunit alpha; Reviewed; Region: ureC; PRK13207 483219002409 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 483219002410 subunit interactions [polypeptide binding]; other site 483219002411 active site 483219002412 flap region; other site 483219002413 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 483219002414 UreF; Region: UreF; pfam01730 483219002415 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 483219002416 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 483219002417 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 483219002418 NAD binding site [chemical binding]; other site 483219002419 catalytic Zn binding site [ion binding]; other site 483219002420 structural Zn binding site [ion binding]; other site 483219002421 Erythromycin esterase; Region: Erythro_esteras; pfam05139 483219002422 SnoaL-like domain; Region: SnoaL_4; pfam13577 483219002423 SnoaL-like domain; Region: SnoaL_3; pfam13474 483219002424 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 483219002425 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 483219002426 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 483219002427 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 483219002428 Cna protein B-type domain; Region: Cna_B_2; pfam13715 483219002429 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 483219002430 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 483219002431 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 483219002432 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 483219002433 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 483219002434 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 483219002435 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 483219002436 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 483219002437 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219002438 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 483219002439 Mg2+ binding site [ion binding]; other site 483219002440 short chain dehydrogenase; Provisional; Region: PRK06181 483219002441 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 483219002442 NAD(P) binding site [chemical binding]; other site 483219002443 active site 483219002444 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 483219002445 Alpha-2-macroglobulin family; Region: A2M; pfam00207 483219002446 MG2 domain; Region: A2M_N; pfam01835 483219002447 Membrane transport protein; Region: Mem_trans; cl09117 483219002448 Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279 483219002449 active site 483219002450 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 483219002451 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 483219002452 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219002453 TPR motif; other site 483219002454 binding surface 483219002455 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219002456 active site 483219002457 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219002458 phosphorylation site [posttranslational modification] 483219002459 intermolecular recognition site; other site 483219002460 dimerization interface [polypeptide binding]; other site 483219002461 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219002462 dimer interface [polypeptide binding]; other site 483219002463 phosphorylation site [posttranslational modification] 483219002464 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219002465 ATP binding site [chemical binding]; other site 483219002466 Mg2+ binding site [ion binding]; other site 483219002467 G-X-G motif; other site 483219002468 Response regulator receiver domain; Region: Response_reg; pfam00072 483219002469 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219002470 active site 483219002471 phosphorylation site [posttranslational modification] 483219002472 intermolecular recognition site; other site 483219002473 dimerization interface [polypeptide binding]; other site 483219002474 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219002475 PAS fold; Region: PAS_3; pfam08447 483219002476 putative active site [active] 483219002477 heme pocket [chemical binding]; other site 483219002478 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 483219002479 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 483219002480 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219002481 PAS domain; Region: PAS_9; pfam13426 483219002482 putative active site [active] 483219002483 heme pocket [chemical binding]; other site 483219002484 GAF domain; Region: GAF; pfam01590 483219002485 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219002486 dimer interface [polypeptide binding]; other site 483219002487 phosphorylation site [posttranslational modification] 483219002488 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219002489 ATP binding site [chemical binding]; other site 483219002490 Mg2+ binding site [ion binding]; other site 483219002491 G-X-G motif; other site 483219002492 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 483219002493 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 483219002494 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 483219002495 active site 483219002496 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 483219002497 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 483219002498 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 483219002499 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 483219002500 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 483219002501 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 483219002502 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 483219002503 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 483219002504 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 483219002505 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 483219002506 ATP binding site [chemical binding]; other site 483219002507 putative Mg++ binding site [ion binding]; other site 483219002508 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 483219002509 nucleotide binding region [chemical binding]; other site 483219002510 ATP-binding site [chemical binding]; other site 483219002511 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 483219002512 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 483219002513 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 483219002514 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 483219002515 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 483219002516 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 483219002517 putative dimerization interface [polypeptide binding]; other site 483219002518 Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose; Region: GT1_Trehalose_phosphorylase; cd03792 483219002519 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 483219002520 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 483219002521 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 483219002522 dimer interface [polypeptide binding]; other site 483219002523 active site residues [active] 483219002524 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 483219002525 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 483219002526 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 483219002527 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 483219002528 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 483219002529 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 483219002530 DNA binding residues [nucleotide binding] 483219002531 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 483219002532 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 483219002533 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 483219002534 metal ion-dependent adhesion site (MIDAS); other site 483219002535 short chain dehydrogenase; Validated; Region: PRK06182 483219002536 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 483219002537 NADP binding site [chemical binding]; other site 483219002538 active site 483219002539 steroid binding site; other site 483219002540 Uncharacterized conserved protein [Function unknown]; Region: COG3339 483219002541 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 483219002542 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219002543 Walker A/P-loop; other site 483219002544 ATP binding site [chemical binding]; other site 483219002545 Q-loop/lid; other site 483219002546 ABC transporter signature motif; other site 483219002547 Walker B; other site 483219002548 D-loop; other site 483219002549 H-loop/switch region; other site 483219002550 TOBE domain; Region: TOBE_2; pfam08402 483219002551 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483219002552 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 483219002553 dimer interface [polypeptide binding]; other site 483219002554 conserved gate region; other site 483219002555 putative PBP binding loops; other site 483219002556 ABC-ATPase subunit interface; other site 483219002557 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 483219002558 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483219002559 dimer interface [polypeptide binding]; other site 483219002560 conserved gate region; other site 483219002561 putative PBP binding loops; other site 483219002562 ABC-ATPase subunit interface; other site 483219002563 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 483219002564 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 483219002565 pfkB-type carbohydrate kinase family protein; Region: PLN02630 483219002566 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 483219002567 Protein of unknown function (DUF2379); Region: DUF2379; pfam09543 483219002568 DNA gyrase subunit A; Validated; Region: PRK05560 483219002569 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 483219002570 CAP-like domain; other site 483219002571 active site 483219002572 primary dimer interface [polypeptide binding]; other site 483219002573 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 483219002574 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 483219002575 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 483219002576 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 483219002577 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 483219002578 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 483219002579 TPR repeat; Region: TPR_11; pfam13414 483219002580 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219002581 TPR motif; other site 483219002582 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 483219002583 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 483219002584 Metallopeptidase family M24; Region: Peptidase_M24; pfam00557 483219002585 active site 483219002586 Response regulator receiver domain; Region: Response_reg; pfam00072 483219002587 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219002588 active site 483219002589 phosphorylation site [posttranslational modification] 483219002590 intermolecular recognition site; other site 483219002591 dimerization interface [polypeptide binding]; other site 483219002592 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 483219002593 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 483219002594 active site 2 [active] 483219002595 active site 1 [active] 483219002596 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 483219002597 active site 2 [active] 483219002598 active site 1 [active] 483219002599 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 483219002600 ligand binding site [chemical binding]; other site 483219002601 active site 483219002602 UGI interface [polypeptide binding]; other site 483219002603 catalytic site [active] 483219002604 Type II/IV secretion system protein; Region: T2SE; pfam00437 483219002605 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 483219002606 ATP binding site [chemical binding]; other site 483219002607 Walker A motif; other site 483219002608 hexamer interface [polypeptide binding]; other site 483219002609 Walker B motif; other site 483219002610 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 483219002611 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219002612 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219002613 active site 483219002614 ATP binding site [chemical binding]; other site 483219002615 substrate binding site [chemical binding]; other site 483219002616 activation loop (A-loop); other site 483219002617 Transglycosylase; Region: Transgly; cl17702 483219002618 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 483219002619 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 483219002620 FAD binding pocket [chemical binding]; other site 483219002621 conserved FAD binding motif [chemical binding]; other site 483219002622 phosphate binding motif [ion binding]; other site 483219002623 beta-alpha-beta structure motif; other site 483219002624 NAD binding pocket [chemical binding]; other site 483219002625 FOG: WD40 repeat [General function prediction only]; Region: COG2319 483219002626 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 483219002627 structural tetrad; other site 483219002628 Aspartyl protease; Region: Asp_protease_2; pfam13650 483219002629 inhibitor binding site; inhibition site 483219002630 catalytic motif [active] 483219002631 Catalytic residue [active] 483219002632 Active site flap [active] 483219002633 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 483219002634 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 483219002635 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 483219002636 putative ligand binding site [chemical binding]; other site 483219002637 chaperone protein DnaJ; Provisional; Region: PRK10767 483219002638 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 483219002639 HSP70 interaction site [polypeptide binding]; other site 483219002640 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 483219002641 substrate binding site [polypeptide binding]; other site 483219002642 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 483219002643 Zn binding sites [ion binding]; other site 483219002644 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 483219002645 dimer interface [polypeptide binding]; other site 483219002646 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 483219002647 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219002648 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 483219002649 Walker A/P-loop; other site 483219002650 ATP binding site [chemical binding]; other site 483219002651 Q-loop/lid; other site 483219002652 ABC transporter signature motif; other site 483219002653 Walker B; other site 483219002654 D-loop; other site 483219002655 H-loop/switch region; other site 483219002656 TadE-like protein; Region: TadE; pfam07811 483219002657 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 483219002658 ATP binding site [chemical binding]; other site 483219002659 putative Mg++ binding site [ion binding]; other site 483219002660 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 483219002661 nucleotide binding region [chemical binding]; other site 483219002662 ATP-binding site [chemical binding]; other site 483219002663 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219002664 PAS domain; Region: PAS_9; pfam13426 483219002665 putative active site [active] 483219002666 heme pocket [chemical binding]; other site 483219002667 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 483219002668 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219002669 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219002670 dimer interface [polypeptide binding]; other site 483219002671 phosphorylation site [posttranslational modification] 483219002672 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219002673 ATP binding site [chemical binding]; other site 483219002674 Mg2+ binding site [ion binding]; other site 483219002675 G-X-G motif; other site 483219002676 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 483219002677 heme-binding residues [chemical binding]; other site 483219002678 Uncharacterized conserved protein [Function unknown]; Region: COG3287 483219002679 FIST N domain; Region: FIST; pfam08495 483219002680 FIST C domain; Region: FIST_C; pfam10442 483219002681 PAS fold; Region: PAS_4; pfam08448 483219002682 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219002683 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219002684 dimer interface [polypeptide binding]; other site 483219002685 phosphorylation site [posttranslational modification] 483219002686 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219002687 ATP binding site [chemical binding]; other site 483219002688 Mg2+ binding site [ion binding]; other site 483219002689 G-X-G motif; other site 483219002690 Response regulator receiver domain; Region: Response_reg; pfam00072 483219002691 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219002692 active site 483219002693 phosphorylation site [posttranslational modification] 483219002694 intermolecular recognition site; other site 483219002695 dimerization interface [polypeptide binding]; other site 483219002696 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 483219002697 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219002698 active site 483219002699 phosphorylation site [posttranslational modification] 483219002700 intermolecular recognition site; other site 483219002701 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 483219002702 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219002703 active site 483219002704 phosphorylation site [posttranslational modification] 483219002705 intermolecular recognition site; other site 483219002706 dimerization interface [polypeptide binding]; other site 483219002707 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219002708 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 483219002709 active site 483219002710 phosphorylation site [posttranslational modification] 483219002711 intermolecular recognition site; other site 483219002712 dimerization interface [polypeptide binding]; other site 483219002713 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 483219002714 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 483219002715 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 483219002716 O-methyltransferase; Region: Methyltransf_2; pfam00891 483219002717 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 483219002718 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 483219002719 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219002720 active site 483219002721 phosphorylation site [posttranslational modification] 483219002722 intermolecular recognition site; other site 483219002723 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 483219002724 DNA binding residues [nucleotide binding] 483219002725 dimerization interface [polypeptide binding]; other site 483219002726 Response regulator receiver domain; Region: Response_reg; pfam00072 483219002727 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219002728 active site 483219002729 phosphorylation site [posttranslational modification] 483219002730 intermolecular recognition site; other site 483219002731 dimerization interface [polypeptide binding]; other site 483219002732 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 483219002733 ABC1 family; Region: ABC1; pfam03109 483219002734 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 483219002735 homogentisate 1,2-dioxygenase; Region: HgmA; cl17306 483219002736 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 483219002737 active site 483219002738 ATP binding site [chemical binding]; other site 483219002739 substrate binding site [chemical binding]; other site 483219002740 activation loop (A-loop); other site 483219002741 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 483219002742 ABC-2 type transporter; Region: ABC2_membrane; cl17235 483219002743 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 483219002744 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219002745 Walker A/P-loop; other site 483219002746 ATP binding site [chemical binding]; other site 483219002747 Q-loop/lid; other site 483219002748 ABC transporter signature motif; other site 483219002749 Walker B; other site 483219002750 D-loop; other site 483219002751 H-loop/switch region; other site 483219002752 GAF domain; Region: GAF; pfam01590 483219002753 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 483219002754 GAF domain; Region: GAF; pfam01590 483219002755 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219002756 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219002757 dimer interface [polypeptide binding]; other site 483219002758 phosphorylation site [posttranslational modification] 483219002759 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219002760 ATP binding site [chemical binding]; other site 483219002761 Mg2+ binding site [ion binding]; other site 483219002762 G-X-G motif; other site 483219002763 Response regulator receiver domain; Region: Response_reg; pfam00072 483219002764 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219002765 active site 483219002766 phosphorylation site [posttranslational modification] 483219002767 intermolecular recognition site; other site 483219002768 dimerization interface [polypeptide binding]; other site 483219002769 CheB methylesterase; Region: CheB_methylest; pfam01339 483219002770 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 483219002771 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 483219002772 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219002773 dimerization interface [polypeptide binding]; other site 483219002774 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 483219002775 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219002776 dimerization interface [polypeptide binding]; other site 483219002777 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219002778 dimerization interface [polypeptide binding]; other site 483219002779 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219002780 dimerization interface [polypeptide binding]; other site 483219002781 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219002782 dimerization interface [polypeptide binding]; other site 483219002783 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 483219002784 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219002785 dimerization interface [polypeptide binding]; other site 483219002786 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219002787 dimerization interface [polypeptide binding]; other site 483219002788 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219002789 dimerization interface [polypeptide binding]; other site 483219002790 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219002791 dimerization interface [polypeptide binding]; other site 483219002792 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 483219002793 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219002794 dimerization interface [polypeptide binding]; other site 483219002795 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219002796 dimerization interface [polypeptide binding]; other site 483219002797 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 483219002798 GAF domain; Region: GAF; pfam01590 483219002799 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219002800 dimer interface [polypeptide binding]; other site 483219002801 phosphorylation site [posttranslational modification] 483219002802 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219002803 ATP binding site [chemical binding]; other site 483219002804 Mg2+ binding site [ion binding]; other site 483219002805 G-X-G motif; other site 483219002806 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 483219002807 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 483219002808 active site 483219002809 phosphorylation site [posttranslational modification] 483219002810 intermolecular recognition site; other site 483219002811 Response regulator receiver domain; Region: Response_reg; pfam00072 483219002812 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219002813 active site 483219002814 phosphorylation site [posttranslational modification] 483219002815 intermolecular recognition site; other site 483219002816 dimerization interface [polypeptide binding]; other site 483219002817 Response regulator receiver domain; Region: Response_reg; pfam00072 483219002818 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219002819 active site 483219002820 phosphorylation site [posttranslational modification] 483219002821 intermolecular recognition site; other site 483219002822 dimerization interface [polypeptide binding]; other site 483219002823 Response regulator receiver domain; Region: Response_reg; pfam00072 483219002824 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219002825 active site 483219002826 phosphorylation site [posttranslational modification] 483219002827 intermolecular recognition site; other site 483219002828 dimerization interface [polypeptide binding]; other site 483219002829 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 483219002830 ATP binding site [chemical binding]; other site 483219002831 Walker A motif; other site 483219002832 Walker B motif; other site 483219002833 KaiC; Region: KaiC; pfam06745 483219002834 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 483219002835 Walker A motif; other site 483219002836 ATP binding site [chemical binding]; other site 483219002837 Walker B motif; other site 483219002838 Protein of unknown function (DUF3703); Region: DUF3703; pfam12487 483219002839 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 483219002840 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 483219002841 TIGR02646 family protein; Region: TIGR02646 483219002842 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219002843 AAA domain; Region: AAA_23; pfam13476 483219002844 Walker A/P-loop; other site 483219002845 ATP binding site [chemical binding]; other site 483219002846 AAA domain; Region: AAA_21; pfam13304 483219002847 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 483219002848 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 483219002849 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 483219002850 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 483219002851 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 483219002852 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 483219002853 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 483219002854 FtsX-like permease family; Region: FtsX; pfam02687 483219002855 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 483219002856 FtsX-like permease family; Region: FtsX; pfam02687 483219002857 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 483219002858 bacteriocin maturation radical SAM protein 1; Region: rSAM_ocin_1; TIGR03975 483219002859 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 483219002860 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 483219002861 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 483219002862 putative ligand binding residues [chemical binding]; other site 483219002863 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 483219002864 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 483219002865 ABC-ATPase subunit interface; other site 483219002866 dimer interface [polypeptide binding]; other site 483219002867 putative PBP binding regions; other site 483219002868 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 483219002869 ABC-ATPase subunit interface; other site 483219002870 dimer interface [polypeptide binding]; other site 483219002871 putative PBP binding regions; other site 483219002872 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 483219002873 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 483219002874 Walker A/P-loop; other site 483219002875 ATP binding site [chemical binding]; other site 483219002876 Q-loop/lid; other site 483219002877 ABC transporter signature motif; other site 483219002878 Walker B; other site 483219002879 D-loop; other site 483219002880 H-loop/switch region; other site 483219002881 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 483219002882 Cytochrome P450; Region: p450; pfam00067 483219002883 Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724 483219002884 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219002885 S-adenosylmethionine binding site [chemical binding]; other site 483219002886 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 483219002887 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 483219002888 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 483219002889 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 483219002890 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 483219002891 Walker A/P-loop; other site 483219002892 ATP binding site [chemical binding]; other site 483219002893 Q-loop/lid; other site 483219002894 ABC transporter signature motif; other site 483219002895 Walker B; other site 483219002896 D-loop; other site 483219002897 H-loop/switch region; other site 483219002898 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 483219002899 Zn binding site [ion binding]; other site 483219002900 Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279 483219002901 active site 483219002902 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 483219002903 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 483219002904 active site 483219002905 catalytic tetrad [active] 483219002906 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 483219002907 putative hydrophobic ligand binding site [chemical binding]; other site 483219002908 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 483219002909 hydrophobic ligand binding site; other site 483219002910 Predicted transcriptional regulator containing an HTH domain fused to a Zn-ribbon [Transcription]; Region: COG3357 483219002911 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 483219002912 DNA-binding site [nucleotide binding]; DNA binding site 483219002913 RNA-binding motif; other site 483219002914 Protein of unknown function DUF99; Region: DUF99; pfam01949 483219002915 hypothetical protein; Provisional; Region: PRK00766 483219002916 Myxococcales-restricted protein, TIGR02265 family; Region: Mxa_TIGR02265 483219002917 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 483219002918 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 483219002919 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 483219002920 HlyD family secretion protein; Region: HlyD_3; pfam13437 483219002921 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 483219002922 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 483219002923 Uncharacterized conserved protein (DUF2293); Region: DUF2293; pfam10056 483219002924 ribonuclease Z; Region: RNase_Z; TIGR02651 483219002925 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 483219002926 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 483219002927 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 483219002928 active site 483219002929 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 483219002930 Tat binding protein 1(TBP-1)-interacting protein (TBPIP); Region: TBPIP; pfam07106 483219002931 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 483219002932 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 483219002933 Substrate binding site [chemical binding]; other site 483219002934 Leucine rich repeat; Region: LRR_8; pfam13855 483219002935 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 483219002936 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 483219002937 MarR family; Region: MarR; pfam01047 483219002938 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 483219002939 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 483219002940 catalytic triad [active] 483219002941 putative active site [active] 483219002942 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 483219002943 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 483219002944 putative metal binding site [ion binding]; other site 483219002945 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 483219002946 putative catalytic site [active] 483219002947 putative phosphate binding site [ion binding]; other site 483219002948 putative metal binding site [ion binding]; other site 483219002949 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 483219002950 HSP70 interaction site [polypeptide binding]; other site 483219002951 Restriction endonuclease XhoI; Region: XhoI; pfam04555 483219002952 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219002953 S-adenosylmethionine binding site [chemical binding]; other site 483219002954 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 483219002955 Peptidase family M1; Region: Peptidase_M1; pfam01433 483219002956 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 483219002957 Zn binding site [ion binding]; other site 483219002958 HEAT repeats; Region: HEAT_2; pfam13646 483219002959 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 483219002960 PAS fold; Region: PAS; pfam00989 483219002961 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219002962 putative active site [active] 483219002963 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219002964 dimer interface [polypeptide binding]; other site 483219002965 phosphorylation site [posttranslational modification] 483219002966 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219002967 ATP binding site [chemical binding]; other site 483219002968 Mg2+ binding site [ion binding]; other site 483219002969 G-X-G motif; other site 483219002970 TspO/MBR family; Region: TspO_MBR; pfam03073 483219002971 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 483219002972 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 483219002973 dinuclear metal binding motif [ion binding]; other site 483219002974 CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080 483219002975 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 483219002976 cyclase homology domain; Region: CHD; cd07302 483219002977 nucleotidyl binding site; other site 483219002978 metal binding site [ion binding]; metal-binding site 483219002979 dimer interface [polypeptide binding]; other site 483219002980 Peptidase family M48; Region: Peptidase_M48; cl12018 483219002981 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 483219002982 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951 483219002983 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 483219002984 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 483219002985 P-loop; other site 483219002986 Magnesium ion binding site [ion binding]; other site 483219002987 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 483219002988 Magnesium ion binding site [ion binding]; other site 483219002989 Afadin- and alpha -actinin-Binding; Region: ADIP; pfam11559 483219002990 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 483219002991 non-specific DNA binding site [nucleotide binding]; other site 483219002992 salt bridge; other site 483219002993 sequence-specific DNA binding site [nucleotide binding]; other site 483219002994 Fatty acid desaturase; Region: FA_desaturase; pfam00487 483219002995 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cd01060 483219002996 putative di-iron ligands [ion binding]; other site 483219002997 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 483219002998 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 483219002999 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 483219003000 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 483219003001 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219003002 Walker B; other site 483219003003 D-loop; other site 483219003004 H-loop/switch region; other site 483219003005 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 483219003006 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219003007 phosphorylation site [posttranslational modification] 483219003008 dimer interface [polypeptide binding]; other site 483219003009 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219003010 ATP binding site [chemical binding]; other site 483219003011 Mg2+ binding site [ion binding]; other site 483219003012 G-X-G motif; other site 483219003013 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cd00138 483219003014 PLD-like domain; Region: PLDc_2; pfam13091 483219003015 putative active site [active] 483219003016 catalytic site [active] 483219003017 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 483219003018 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 483219003019 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 483219003020 Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134 483219003021 NAD(P) binding site [chemical binding]; other site 483219003022 catalytic residues [active] 483219003023 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 483219003024 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 483219003025 NAD(P) binding site [chemical binding]; other site 483219003026 catalytic residues [active] 483219003027 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 483219003028 Bacterial PH domain; Region: DUF304; pfam03703 483219003029 Bacterial PH domain; Region: DUF304; pfam03703 483219003030 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 483219003031 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 483219003032 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219003033 Walker A/P-loop; other site 483219003034 ATP binding site [chemical binding]; other site 483219003035 Q-loop/lid; other site 483219003036 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 483219003037 ABC transporter signature motif; other site 483219003038 Walker B; other site 483219003039 D-loop; other site 483219003040 ABC transporter; Region: ABC_tran_2; pfam12848 483219003041 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 483219003042 B3/4 domain; Region: B3_4; pfam03483 483219003043 Protein of unknown function, DUF481; Region: DUF481; pfam04338 483219003044 CBS domain; Region: CBS; pfam00571 483219003045 dihydroxyacetone kinase; Provisional; Region: PRK14479 483219003046 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 483219003047 DAK2 domain; Region: Dak2; pfam02734 483219003048 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 483219003049 active site clefts [active] 483219003050 zinc binding site [ion binding]; other site 483219003051 dimer interface [polypeptide binding]; other site 483219003052 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 483219003053 AAA domain; Region: AAA_33; pfam13671 483219003054 ATP-binding site [chemical binding]; other site 483219003055 Gluconate-6-phosphate binding site [chemical binding]; other site 483219003056 DNA ligase; Provisional; Region: PRK09125 483219003057 Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896 483219003058 DNA binding site [nucleotide binding] 483219003059 active site 483219003060 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041 483219003061 DNA binding site [nucleotide binding] 483219003062 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219003063 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219003064 active site 483219003065 ATP binding site [chemical binding]; other site 483219003066 substrate binding site [chemical binding]; other site 483219003067 activation loop (A-loop); other site 483219003068 PilZ domain; Region: PilZ; pfam07238 483219003069 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734 483219003070 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219003071 putative active site [active] 483219003072 heme pocket [chemical binding]; other site 483219003073 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 483219003074 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 483219003075 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 483219003076 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219003077 putative active site [active] 483219003078 heme pocket [chemical binding]; other site 483219003079 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219003080 dimer interface [polypeptide binding]; other site 483219003081 phosphorylation site [posttranslational modification] 483219003082 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219003083 ATP binding site [chemical binding]; other site 483219003084 Mg2+ binding site [ion binding]; other site 483219003085 G-X-G motif; other site 483219003086 serine O-acetyltransferase; Region: cysE; TIGR01172 483219003087 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 483219003088 putative CoA binding site [chemical binding]; other site 483219003089 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 483219003090 trimer interface [polypeptide binding]; other site 483219003091 active site 483219003092 substrate binding site [chemical binding]; other site 483219003093 CoA binding site [chemical binding]; other site 483219003094 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 483219003095 putative active site [active] 483219003096 Zn binding site [ion binding]; other site 483219003097 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 483219003098 active site 483219003099 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 483219003100 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 483219003101 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 483219003102 NAD(P) binding site [chemical binding]; other site 483219003103 catalytic residues [active] 483219003104 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 483219003105 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219003106 Walker A motif; other site 483219003107 ATP binding site [chemical binding]; other site 483219003108 Walker B motif; other site 483219003109 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 483219003110 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 483219003111 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 483219003112 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483219003113 conserved gate region; other site 483219003114 ABC-ATPase subunit interface; other site 483219003115 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 483219003116 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219003117 Walker A/P-loop; other site 483219003118 ATP binding site [chemical binding]; other site 483219003119 Q-loop/lid; other site 483219003120 ABC transporter signature motif; other site 483219003121 Walker B; other site 483219003122 D-loop; other site 483219003123 H-loop/switch region; other site 483219003124 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 483219003125 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 483219003126 Mechanosensitive ion channel; Region: MS_channel; pfam00924 483219003127 HEAT repeats; Region: HEAT_2; pfam13646 483219003128 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 483219003129 active site 483219003130 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 483219003131 MG2 domain; Region: A2M_N; pfam01835 483219003132 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 483219003133 Alpha-2-macroglobulin family; Region: A2M; pfam00207 483219003134 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 483219003135 surface patch; other site 483219003136 thioester region; other site 483219003137 Protein of unknown function (DUF1175); Region: DUF1175; cl14898 483219003138 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 483219003139 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 483219003140 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 483219003141 Protein of unknown function (DUF938); Region: DUF938; pfam06080 483219003142 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 483219003143 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 483219003144 Low molecular weight phosphatase family; Region: LMWPc; cl00105 483219003145 active site 483219003146 PAS fold; Region: PAS_4; pfam08448 483219003147 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219003148 putative active site [active] 483219003149 heme pocket [chemical binding]; other site 483219003150 PAS fold; Region: PAS; pfam00989 483219003151 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219003152 putative active site [active] 483219003153 heme pocket [chemical binding]; other site 483219003154 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219003155 PAS fold; Region: PAS_3; pfam08447 483219003156 putative active site [active] 483219003157 heme pocket [chemical binding]; other site 483219003158 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219003159 dimer interface [polypeptide binding]; other site 483219003160 phosphorylation site [posttranslational modification] 483219003161 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 483219003162 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219003163 ATP binding site [chemical binding]; other site 483219003164 Mg2+ binding site [ion binding]; other site 483219003165 G-X-G motif; other site 483219003166 Staphylococcal nuclease homologues; Region: SNc; smart00318 483219003167 Catalytic site; other site 483219003168 Staphylococcal nuclease homologue; Region: SNase; pfam00565 483219003169 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 483219003170 Putative esterase; Region: Esterase; pfam00756 483219003171 Myxococcales-restricted protein, TIGR02265 family; Region: Mxa_TIGR02265 483219003172 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 483219003173 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 483219003174 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 483219003175 heat shock protein HtpX; Provisional; Region: PRK05457 483219003176 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 483219003177 active site 483219003178 zinc binding site [ion binding]; other site 483219003179 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 483219003180 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 483219003181 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 483219003182 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 483219003183 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 483219003184 AAA domain; Region: AAA_21; pfam13304 483219003185 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 483219003186 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 483219003187 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 483219003188 ABC transporter; Region: ABC_tran_2; pfam12848 483219003189 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 483219003190 Protein of unknown function (DUF2379); Region: DUF2379; pfam09543 483219003191 Cupin domain; Region: Cupin_2; pfam07883 483219003192 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 483219003193 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 483219003194 DNA-binding site [nucleotide binding]; DNA binding site 483219003195 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 483219003196 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483219003197 homodimer interface [polypeptide binding]; other site 483219003198 catalytic residue [active] 483219003199 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 483219003200 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 483219003201 active site 483219003202 metal binding site [ion binding]; metal-binding site 483219003203 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 483219003204 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 483219003205 Walker A/P-loop; other site 483219003206 ATP binding site [chemical binding]; other site 483219003207 Q-loop/lid; other site 483219003208 ABC transporter signature motif; other site 483219003209 Walker B; other site 483219003210 D-loop; other site 483219003211 H-loop/switch region; other site 483219003212 ABC-2 type transporter; Region: ABC2_membrane; cl17235 483219003213 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 483219003214 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219003215 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219003216 active site 483219003217 ATP binding site [chemical binding]; other site 483219003218 substrate binding site [chemical binding]; other site 483219003219 activation loop (A-loop); other site 483219003220 PEGA domain; Region: PEGA; pfam08308 483219003221 HEAT repeats; Region: HEAT_2; pfam13646 483219003222 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 483219003223 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 483219003224 putative C-terminal domain interface [polypeptide binding]; other site 483219003225 putative GSH binding site (G-site) [chemical binding]; other site 483219003226 putative dimer interface [polypeptide binding]; other site 483219003227 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 483219003228 dimer interface [polypeptide binding]; other site 483219003229 N-terminal domain interface [polypeptide binding]; other site 483219003230 putative substrate binding pocket (H-site) [chemical binding]; other site 483219003231 Cupin superfamily protein; Region: Cupin_4; pfam08007 483219003232 Domain of unknown function (DUF4135); Region: DUF4135; pfam13575 483219003233 hypothetical protein; Provisional; Region: PRK07907 483219003234 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682 483219003235 metal binding site [ion binding]; metal-binding site 483219003236 putative dimer interface [polypeptide binding]; other site 483219003237 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 483219003238 sugar binding site [chemical binding]; other site 483219003239 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 483219003240 sugar binding site [chemical binding]; other site 483219003241 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 483219003242 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 483219003243 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 483219003244 catalytic site [active] 483219003245 active site 483219003246 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 483219003247 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219003248 Walker A motif; other site 483219003249 ATP binding site [chemical binding]; other site 483219003250 Walker B motif; other site 483219003251 arginine finger; other site 483219003252 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 483219003253 Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279 483219003254 active site 483219003255 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 483219003256 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 483219003257 putative active site [active] 483219003258 catalytic site [active] 483219003259 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 483219003260 putative active site [active] 483219003261 catalytic site [active] 483219003262 potential frameshift: common BLAST hit: gi|108761008|ref|YP_628804.1| RecQ family DNA topoisomerase III/ATP-dependent DNA helicase 483219003263 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 483219003264 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 483219003265 NAD(P) binding site [chemical binding]; other site 483219003266 active site 483219003267 TLC ATP/ADP transporter; Region: TLC; cl03940 483219003268 aspartate aminotransferase; Provisional; Region: PRK05764 483219003269 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 483219003270 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483219003271 homodimer interface [polypeptide binding]; other site 483219003272 catalytic residue [active] 483219003273 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 483219003274 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 483219003275 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 483219003276 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 483219003277 HlyD family secretion protein; Region: HlyD_3; pfam13437 483219003278 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219003279 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219003280 active site 483219003281 ATP binding site [chemical binding]; other site 483219003282 substrate binding site [chemical binding]; other site 483219003283 activation loop (A-loop); other site 483219003284 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219003285 Walker A/P-loop; other site 483219003286 ATP binding site [chemical binding]; other site 483219003287 Q-loop/lid; other site 483219003288 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 483219003289 Uncharacterized conserved protein [Function unknown]; Region: COG1262 483219003290 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 483219003291 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 483219003292 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219003293 active site 483219003294 phosphorylation site [posttranslational modification] 483219003295 intermolecular recognition site; other site 483219003296 dimerization interface [polypeptide binding]; other site 483219003297 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 483219003298 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 483219003299 nucleotide binding site/active site [active] 483219003300 HIT family signature motif; other site 483219003301 catalytic residue [active] 483219003302 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 483219003303 AAA domain; Region: AAA_11; pfam13086 483219003304 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219003305 Walker A motif; other site 483219003306 ATP binding site [chemical binding]; other site 483219003307 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 483219003308 AAA domain; Region: AAA_12; pfam13087 483219003309 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 483219003310 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 483219003311 putative active site [active] 483219003312 Tetratricopeptide repeat; Region: TPR_12; pfam13424 483219003313 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219003314 binding surface 483219003315 TPR motif; other site 483219003316 PEGA domain; Region: PEGA; pfam08308 483219003317 PEGA domain; Region: PEGA; pfam08308 483219003318 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 483219003319 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 483219003320 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 483219003321 Coenzyme A binding pocket [chemical binding]; other site 483219003322 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 483219003323 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 483219003324 FMN binding site [chemical binding]; other site 483219003325 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 483219003326 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 483219003327 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 483219003328 dimer interface [polypeptide binding]; other site 483219003329 active site 483219003330 metal binding site [ion binding]; metal-binding site 483219003331 glutathione binding site [chemical binding]; other site 483219003332 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 483219003333 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 483219003334 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 483219003335 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 483219003336 putative NADH binding site [chemical binding]; other site 483219003337 putative active site [active] 483219003338 nudix motif; other site 483219003339 putative metal binding site [ion binding]; other site 483219003340 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 483219003341 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 483219003342 FeS/SAM binding site; other site 483219003343 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 483219003344 GIY-YIG motif/motif A; other site 483219003345 putative active site [active] 483219003346 putative metal binding site [ion binding]; other site 483219003347 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 483219003348 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 483219003349 SurA N-terminal domain; Region: SurA_N_3; cl07813 483219003350 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 483219003351 SurA N-terminal domain; Region: SurA_N; pfam09312 483219003352 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 483219003353 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 483219003354 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 483219003355 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 483219003356 SnoaL-like domain; Region: SnoaL_2; pfam12680 483219003357 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 483219003358 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 483219003359 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 483219003360 active site 483219003361 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 483219003362 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219003363 active site 483219003364 phosphorylation site [posttranslational modification] 483219003365 intermolecular recognition site; other site 483219003366 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219003367 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219003368 ATP binding site [chemical binding]; other site 483219003369 Mg2+ binding site [ion binding]; other site 483219003370 G-X-G motif; other site 483219003371 Response regulator receiver domain; Region: Response_reg; pfam00072 483219003372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219003373 active site 483219003374 phosphorylation site [posttranslational modification] 483219003375 intermolecular recognition site; other site 483219003376 dimerization interface [polypeptide binding]; other site 483219003377 Response regulator receiver domain; Region: Response_reg; pfam00072 483219003378 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219003379 active site 483219003380 phosphorylation site [posttranslational modification] 483219003381 intermolecular recognition site; other site 483219003382 dimerization interface [polypeptide binding]; other site 483219003383 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219003384 dimer interface [polypeptide binding]; other site 483219003385 phosphorylation site [posttranslational modification] 483219003386 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219003387 ATP binding site [chemical binding]; other site 483219003388 Mg2+ binding site [ion binding]; other site 483219003389 G-X-G motif; other site 483219003390 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 483219003391 30S subunit binding site; other site 483219003392 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 483219003393 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 483219003394 putative NAD(P) binding site [chemical binding]; other site 483219003395 putative substrate binding site [chemical binding]; other site 483219003396 catalytic Zn binding site [ion binding]; other site 483219003397 structural Zn binding site [ion binding]; other site 483219003398 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 483219003399 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 483219003400 active site 483219003401 catalytic tetrad [active] 483219003402 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 483219003403 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 483219003404 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 483219003405 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 483219003406 active site 483219003407 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 483219003408 Predicted membrane protein [Function unknown]; Region: COG2246 483219003409 GtrA-like protein; Region: GtrA; pfam04138 483219003410 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 483219003411 active site 483219003412 catalytic residues [active] 483219003413 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 483219003414 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 483219003415 Cupin domain; Region: Cupin_2; cl17218 483219003416 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 483219003417 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 483219003418 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 483219003419 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 483219003420 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 483219003421 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 483219003422 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 483219003423 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 483219003424 MOSC domain; Region: MOSC; pfam03473 483219003425 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 483219003426 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 483219003427 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 483219003428 active site 483219003429 catalytic site [active] 483219003430 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 483219003431 Methyltransferase domain; Region: Methyltransf_23; pfam13489 483219003432 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219003433 S-adenosylmethionine binding site [chemical binding]; other site 483219003434 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 483219003435 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 483219003436 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 483219003437 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 483219003438 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 483219003439 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 483219003440 active site 483219003441 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 483219003442 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cl04528 483219003443 Uncharacterized conserved protein [Function unknown]; Region: COG1915 483219003444 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 483219003445 active site 483219003446 catalytic residues [active] 483219003447 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 483219003448 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 483219003449 NlpC/P60 family; Region: NLPC_P60; cl17555 483219003450 Transcriptional regulator [Transcription]; Region: LysR; COG0583 483219003451 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 483219003452 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 483219003453 dimerization interface [polypeptide binding]; other site 483219003454 yiaA/B two helix domain; Region: YiaAB; cl01759 483219003455 Domain of unknown function (DUF4419); Region: DUF4419; pfam14388 483219003456 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 483219003457 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 483219003458 Walker A motif; other site 483219003459 ATP binding site [chemical binding]; other site 483219003460 Walker B motif; other site 483219003461 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 483219003462 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 483219003463 putative active site [active] 483219003464 putative metal binding site [ion binding]; other site 483219003465 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 483219003466 Cupin domain; Region: Cupin_2; cl17218 483219003467 Methyltransferase domain; Region: Methyltransf_31; pfam13847 483219003468 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219003469 S-adenosylmethionine binding site [chemical binding]; other site 483219003470 Helix-turn-helix domain; Region: HTH_17; pfam12728 483219003471 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 483219003472 Citrate synthase; Region: Citrate_synt; pfam00285 483219003473 dimer interface [polypeptide binding]; other site 483219003474 active site 483219003475 oxalacetate/citrate binding site [chemical binding]; other site 483219003476 citrylCoA binding site [chemical binding]; other site 483219003477 coenzyme A binding site [chemical binding]; other site 483219003478 catalytic triad [active] 483219003479 GTP-binding protein YchF; Reviewed; Region: PRK09601 483219003480 YchF GTPase; Region: YchF; cd01900 483219003481 G1 box; other site 483219003482 GTP/Mg2+ binding site [chemical binding]; other site 483219003483 Switch I region; other site 483219003484 G2 box; other site 483219003485 Switch II region; other site 483219003486 G3 box; other site 483219003487 G4 box; other site 483219003488 G5 box; other site 483219003489 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 483219003490 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 483219003491 F0F1 ATP synthase subunit B; Provisional; Region: PRK13461 483219003492 ATP synthase subunit C; Region: ATP-synt_C; cl00466 483219003493 ATP synthase A chain; Region: ATP-synt_A; cl00413 483219003494 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 483219003495 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 483219003496 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 483219003497 substrate binding site [chemical binding]; other site 483219003498 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219003499 putative active site [active] 483219003500 heme pocket [chemical binding]; other site 483219003501 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 483219003502 GAF domain; Region: GAF; pfam01590 483219003503 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 483219003504 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 483219003505 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219003506 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219003507 active site 483219003508 ATP binding site [chemical binding]; other site 483219003509 substrate binding site [chemical binding]; other site 483219003510 activation loop (A-loop); other site 483219003511 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 483219003512 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 483219003513 inhibitor-cofactor binding pocket; inhibition site 483219003514 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483219003515 catalytic residue [active] 483219003516 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 483219003517 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 483219003518 DNA binding site [nucleotide binding] 483219003519 active site 483219003520 Int/Topo IB signature motif; other site 483219003521 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 483219003522 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 483219003523 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 483219003524 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_15; cd07264 483219003525 MgtE intracellular N domain; Region: MgtE_N; smart00924 483219003526 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 483219003527 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 483219003528 Divalent cation transporter; Region: MgtE; pfam01769 483219003529 TPR repeat; Region: TPR_11; pfam13414 483219003530 Replication protein A C terminal; Region: RPA_C; pfam08784 483219003531 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 483219003532 short chain dehydrogenase; Provisional; Region: PRK05650 483219003533 classical (c) SDRs; Region: SDR_c; cd05233 483219003534 NAD(P) binding site [chemical binding]; other site 483219003535 active site 483219003536 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 483219003537 Histidine kinase; Region: His_kinase; pfam06580 483219003538 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 483219003539 ATP binding site [chemical binding]; other site 483219003540 Mg2+ binding site [ion binding]; other site 483219003541 G-X-G motif; other site 483219003542 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 483219003543 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219003544 active site 483219003545 phosphorylation site [posttranslational modification] 483219003546 intermolecular recognition site; other site 483219003547 dimerization interface [polypeptide binding]; other site 483219003548 LytTr DNA-binding domain; Region: LytTR; smart00850 483219003549 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 483219003550 lipoprotein signal peptidase; Provisional; Region: PRK14773 483219003551 lipoprotein signal peptidase; Provisional; Region: PRK14787 483219003552 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 483219003553 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 483219003554 putative catalytic site [active] 483219003555 putative metal binding site [ion binding]; other site 483219003556 putative phosphate binding site [ion binding]; other site 483219003557 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 483219003558 Uncharacterized conserved protein [Function unknown]; Region: COG1656 483219003559 Protein of unknown function DUF82; Region: DUF82; pfam01927 483219003560 potential frameshift: common BLAST hit: gi|108757420|ref|YP_628636.1| putative pilus biogenesis operon protein 483219003561 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 483219003562 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 483219003563 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 483219003564 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 483219003565 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 483219003566 active site 483219003567 HIGH motif; other site 483219003568 nucleotide binding site [chemical binding]; other site 483219003569 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 483219003570 active site 483219003571 KMSKS motif; other site 483219003572 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 483219003573 tRNA binding surface [nucleotide binding]; other site 483219003574 anticodon binding site; other site 483219003575 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 483219003576 TadE-like protein; Region: TadE; pfam07811 483219003577 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 483219003578 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 483219003579 phosphopeptide binding site; other site 483219003580 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 483219003581 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219003582 Walker A motif; other site 483219003583 ATP binding site [chemical binding]; other site 483219003584 Walker B motif; other site 483219003585 arginine finger; other site 483219003586 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 483219003587 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 483219003588 ATP-grasp domain; Region: ATP-grasp_4; cl17255 483219003589 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 483219003590 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 483219003591 PAS domain S-box; Region: sensory_box; TIGR00229 483219003592 PAS domain; Region: PAS; smart00091 483219003593 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 483219003594 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219003595 putative active site [active] 483219003596 heme pocket [chemical binding]; other site 483219003597 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219003598 dimer interface [polypeptide binding]; other site 483219003599 phosphorylation site [posttranslational modification] 483219003600 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219003601 ATP binding site [chemical binding]; other site 483219003602 Mg2+ binding site [ion binding]; other site 483219003603 G-X-G motif; other site 483219003604 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 483219003605 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 483219003606 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 483219003607 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 483219003608 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 483219003609 amidase catalytic site [active] 483219003610 Zn binding residues [ion binding]; other site 483219003611 substrate binding site [chemical binding]; other site 483219003612 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 483219003613 Deinococcus radiodurans DR1119 and related proteins, metallophosphatase domain; Region: MPP_DR1119; cd07393 483219003614 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 483219003615 putative active site [active] 483219003616 putative metal binding site [ion binding]; other site 483219003617 Myxococcales-restricted protein, TIGR02265 family; Region: Mxa_TIGR02265 483219003618 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 483219003619 potassium uptake protein; Region: kup; TIGR00794 483219003620 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219003621 PAS domain; Region: PAS_9; pfam13426 483219003622 putative active site [active] 483219003623 heme pocket [chemical binding]; other site 483219003624 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219003625 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219003626 dimer interface [polypeptide binding]; other site 483219003627 phosphorylation site [posttranslational modification] 483219003628 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219003629 ATP binding site [chemical binding]; other site 483219003630 Mg2+ binding site [ion binding]; other site 483219003631 G-X-G motif; other site 483219003632 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 483219003633 putative di-iron ligands [ion binding]; other site 483219003634 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 483219003635 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 483219003636 heme-binding site [chemical binding]; other site 483219003637 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219003638 active site 483219003639 phosphorylation site [posttranslational modification] 483219003640 intermolecular recognition site; other site 483219003641 dimerization interface [polypeptide binding]; other site 483219003642 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219003643 PAS fold; Region: PAS_3; pfam08447 483219003644 putative active site [active] 483219003645 heme pocket [chemical binding]; other site 483219003646 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 483219003647 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 483219003648 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219003649 dimer interface [polypeptide binding]; other site 483219003650 phosphorylation site [posttranslational modification] 483219003651 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219003652 ATP binding site [chemical binding]; other site 483219003653 Mg2+ binding site [ion binding]; other site 483219003654 G-X-G motif; other site 483219003655 5'-3' exonuclease; Region: 53EXOc; smart00475 483219003656 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 483219003657 active site 483219003658 metal binding site 1 [ion binding]; metal-binding site 483219003659 putative 5' ssDNA interaction site; other site 483219003660 metal binding site 3; metal-binding site 483219003661 metal binding site 2 [ion binding]; metal-binding site 483219003662 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 483219003663 putative DNA binding site [nucleotide binding]; other site 483219003664 putative metal binding site [ion binding]; other site 483219003665 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 483219003666 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 483219003667 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 483219003668 ligand binding site [chemical binding]; other site 483219003669 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 483219003670 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 483219003671 Domain of unknown function (DUF1338); Region: DUF1338; cl02226 483219003672 Domain of unknown function (DUF1338); Region: DUF1338; cl02226 483219003673 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 483219003674 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 483219003675 Coenzyme A binding pocket [chemical binding]; other site 483219003676 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 483219003677 Phage Tail Collar Domain; Region: Collar; pfam07484 483219003678 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 483219003679 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 483219003680 inhibitor-cofactor binding pocket; inhibition site 483219003681 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483219003682 catalytic residue [active] 483219003683 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 483219003684 Di-iron ligands [ion binding]; other site 483219003685 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 483219003686 Protein of unknown function, DUF482; Region: DUF482; pfam04339 483219003687 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 483219003688 PAS domain S-box; Region: sensory_box; TIGR00229 483219003689 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219003690 putative active site [active] 483219003691 heme pocket [chemical binding]; other site 483219003692 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219003693 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219003694 dimer interface [polypeptide binding]; other site 483219003695 phosphorylation site [posttranslational modification] 483219003696 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219003697 ATP binding site [chemical binding]; other site 483219003698 Mg2+ binding site [ion binding]; other site 483219003699 G-X-G motif; other site 483219003700 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 483219003701 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219003702 active site 483219003703 phosphorylation site [posttranslational modification] 483219003704 intermolecular recognition site; other site 483219003705 dimerization interface [polypeptide binding]; other site 483219003706 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 483219003707 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 483219003708 active site 483219003709 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 483219003710 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219003711 Walker A motif; other site 483219003712 ATP binding site [chemical binding]; other site 483219003713 Walker B motif; other site 483219003714 arginine finger; other site 483219003715 Bacterial SH3 domain; Region: SH3_3; pfam08239 483219003716 Panthothenate kinase [Coenzyme metabolism]; Region: CoaA; COG1072 483219003717 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 483219003718 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 483219003719 DNA binding residues [nucleotide binding] 483219003720 dimerization interface [polypeptide binding]; other site 483219003721 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219003722 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 483219003723 Walker A motif; other site 483219003724 ATP binding site [chemical binding]; other site 483219003725 Walker B motif; other site 483219003726 arginine finger; other site 483219003727 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 483219003728 acyl-activating enzyme (AAE) consensus motif; other site 483219003729 active site 483219003730 AMP binding site [chemical binding]; other site 483219003731 PAS domain; Region: PAS_9; pfam13426 483219003732 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 483219003733 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219003734 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 483219003735 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 483219003736 dimer interface [polypeptide binding]; other site 483219003737 phosphorylation site [posttranslational modification] 483219003738 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219003739 ATP binding site [chemical binding]; other site 483219003740 Mg2+ binding site [ion binding]; other site 483219003741 G-X-G motif; other site 483219003742 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 483219003743 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 483219003744 active site 483219003745 catalytic tetrad [active] 483219003746 Radical SAM superfamily; Region: Radical_SAM; pfam04055 483219003747 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 483219003748 FeS/SAM binding site; other site 483219003749 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 483219003750 Ligand Binding Site [chemical binding]; other site 483219003751 Molecular Tunnel; other site 483219003752 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 483219003753 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 483219003754 homodimer interface [polypeptide binding]; other site 483219003755 active site 483219003756 TDP-binding site; other site 483219003757 ethanolamine utilization protein EutJ; Provisional; Region: PRK15080 483219003758 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 483219003759 HNH endonuclease; Region: HNH_2; pfam13391 483219003760 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 483219003761 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483219003762 putative substrate translocation pore; other site 483219003763 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 483219003764 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 483219003765 putative catalytic residue [active] 483219003766 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 483219003767 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 483219003768 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 483219003769 DsbD alpha interface [polypeptide binding]; other site 483219003770 catalytic residues [active] 483219003771 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 483219003772 metal ion-dependent adhesion site (MIDAS); other site 483219003773 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 483219003774 Cysteine-rich domain; Region: CCG; pfam02754 483219003775 Cysteine-rich domain; Region: CCG; pfam02754 483219003776 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 483219003777 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 483219003778 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 483219003779 translocation protein TolB; Provisional; Region: tolB; PRK04792 483219003780 Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cd11375 483219003781 active site 483219003782 Zn binding site [ion binding]; other site 483219003783 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 483219003784 hypothetical protein; Reviewed; Region: PRK09588 483219003785 Ribosome-binding factor A; Region: RBFA; pfam02033 483219003786 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 483219003787 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 483219003788 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 483219003789 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 483219003790 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 483219003791 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 483219003792 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 483219003793 TolR protein; Region: tolR; TIGR02801 483219003794 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 483219003795 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 483219003796 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 483219003797 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 483219003798 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 483219003799 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 483219003800 putative hydrophobic ligand binding site [chemical binding]; other site 483219003801 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 483219003802 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 483219003803 NAD binding site [chemical binding]; other site 483219003804 catalytic Zn binding site [ion binding]; other site 483219003805 structural Zn binding site [ion binding]; other site 483219003806 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 483219003807 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 483219003808 active site 483219003809 metal binding site [ion binding]; metal-binding site 483219003810 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219003811 active site 483219003812 ATP binding site [chemical binding]; other site 483219003813 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219003814 substrate binding site [chemical binding]; other site 483219003815 activation loop (A-loop); other site 483219003816 PEGA domain; Region: PEGA; pfam08308 483219003817 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 483219003818 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219003819 ATP binding site [chemical binding]; other site 483219003820 Mg2+ binding site [ion binding]; other site 483219003821 G-X-G motif; other site 483219003822 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 483219003823 anchoring element; other site 483219003824 dimer interface [polypeptide binding]; other site 483219003825 ATP binding site [chemical binding]; other site 483219003826 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 483219003827 active site 483219003828 putative metal-binding site [ion binding]; other site 483219003829 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 483219003830 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 483219003831 Coenzyme A binding pocket [chemical binding]; other site 483219003832 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219003833 active site 483219003834 phosphorylation site [posttranslational modification] 483219003835 intermolecular recognition site; other site 483219003836 dimerization interface [polypeptide binding]; other site 483219003837 Response regulator receiver domain; Region: Response_reg; pfam00072 483219003838 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219003839 active site 483219003840 phosphorylation site [posttranslational modification] 483219003841 intermolecular recognition site; other site 483219003842 GAF domain; Region: GAF; cl17456 483219003843 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219003844 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219003845 ATP binding site [chemical binding]; other site 483219003846 Mg2+ binding site [ion binding]; other site 483219003847 G-X-G motif; other site 483219003848 Response regulator receiver domain; Region: Response_reg; pfam00072 483219003849 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219003850 active site 483219003851 phosphorylation site [posttranslational modification] 483219003852 intermolecular recognition site; other site 483219003853 dimerization interface [polypeptide binding]; other site 483219003854 CHASE3 domain; Region: CHASE3; cl05000 483219003855 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219003856 ATP binding site [chemical binding]; other site 483219003857 Mg2+ binding site [ion binding]; other site 483219003858 G-X-G motif; other site 483219003859 Myxococcales-restricted protein, TIGR02265 family; Region: Mxa_TIGR02265 483219003860 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 483219003861 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 483219003862 catalytic residue [active] 483219003863 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 483219003864 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 483219003865 metal binding site [ion binding]; metal-binding site 483219003866 ATP-grasp ribosomal peptide maturase, SAV_5884 family; Region: GRASP_SAV_5884; TIGR04187 483219003867 ATP-grasp domain; Region: ATP-grasp_4; cl17255 483219003868 conserved hypothetical protein; Region: TIGR02270 483219003869 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 483219003870 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 483219003871 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 483219003872 mce related protein; Region: MCE; pfam02470 483219003873 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 483219003874 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 483219003875 Walker A/P-loop; other site 483219003876 ATP binding site [chemical binding]; other site 483219003877 Q-loop/lid; other site 483219003878 ABC transporter signature motif; other site 483219003879 Walker B; other site 483219003880 D-loop; other site 483219003881 H-loop/switch region; other site 483219003882 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 483219003883 Permease; Region: Permease; pfam02405 483219003884 recombination protein F; Reviewed; Region: recF; PRK00064 483219003885 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219003886 Walker A/P-loop; other site 483219003887 ATP binding site [chemical binding]; other site 483219003888 Q-loop/lid; other site 483219003889 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219003890 ABC transporter signature motif; other site 483219003891 Walker B; other site 483219003892 D-loop; other site 483219003893 H-loop/switch region; other site 483219003894 PAS fold; Region: PAS_4; pfam08448 483219003895 PAS fold; Region: PAS_4; pfam08448 483219003896 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 483219003897 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219003898 dimer interface [polypeptide binding]; other site 483219003899 phosphorylation site [posttranslational modification] 483219003900 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219003901 ATP binding site [chemical binding]; other site 483219003902 Mg2+ binding site [ion binding]; other site 483219003903 G-X-G motif; other site 483219003904 potential frameshift: common BLAST hit: gi|89898970|ref|YP_521441.1| putative DNA alkylation repair enzyme 483219003905 Protein of unknown function (Gmx_para_CXXCG); Region: Gmx_para_CXXCG; cl15282 483219003906 Predicted lipoprotein of unknown function (DUF2380); Region: DUF2380; cl15289 483219003907 Domain of unknown function (DUF1990); Region: DUF1990; cl01969 483219003908 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 483219003909 Predicted membrane protein [Function unknown]; Region: COG3918 483219003910 DNA polymerase III subunit beta; Validated; Region: PRK05643 483219003911 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 483219003912 putative DNA binding surface [nucleotide binding]; other site 483219003913 dimer interface [polypeptide binding]; other site 483219003914 beta-clamp/clamp loader binding surface; other site 483219003915 beta-clamp/translesion DNA polymerase binding surface; other site 483219003916 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 483219003917 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 483219003918 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 483219003919 B12 binding domain; Region: B12-binding_2; pfam02607 483219003920 B12 binding domain; Region: B12-binding; pfam02310 483219003921 B12 binding site [chemical binding]; other site 483219003922 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219003923 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219003924 dimer interface [polypeptide binding]; other site 483219003925 phosphorylation site [posttranslational modification] 483219003926 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219003927 ATP binding site [chemical binding]; other site 483219003928 Mg2+ binding site [ion binding]; other site 483219003929 G-X-G motif; other site 483219003930 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 483219003931 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219003932 active site 483219003933 phosphorylation site [posttranslational modification] 483219003934 intermolecular recognition site; other site 483219003935 dimerization interface [polypeptide binding]; other site 483219003936 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 483219003937 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219003938 active site 483219003939 phosphorylation site [posttranslational modification] 483219003940 intermolecular recognition site; other site 483219003941 dimerization interface [polypeptide binding]; other site 483219003942 Response regulator receiver domain; Region: Response_reg; pfam00072 483219003943 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219003944 active site 483219003945 phosphorylation site [posttranslational modification] 483219003946 intermolecular recognition site; other site 483219003947 dimerization interface [polypeptide binding]; other site 483219003948 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219003949 dimer interface [polypeptide binding]; other site 483219003950 phosphorylation site [posttranslational modification] 483219003951 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 483219003952 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219003953 ATP binding site [chemical binding]; other site 483219003954 Mg2+ binding site [ion binding]; other site 483219003955 G-X-G motif; other site 483219003956 Response regulator receiver domain; Region: Response_reg; pfam00072 483219003957 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219003958 active site 483219003959 phosphorylation site [posttranslational modification] 483219003960 intermolecular recognition site; other site 483219003961 dimerization interface [polypeptide binding]; other site 483219003962 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 483219003963 sequence-specific DNA binding site [nucleotide binding]; other site 483219003964 salt bridge; other site 483219003965 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 483219003966 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219003967 dimerization interface [polypeptide binding]; other site 483219003968 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 483219003969 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 483219003970 dimer interface [polypeptide binding]; other site 483219003971 putative CheW interface [polypeptide binding]; other site 483219003972 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219003973 ATP binding site [chemical binding]; other site 483219003974 G-X-G motif; other site 483219003975 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 483219003976 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 483219003977 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 483219003978 acyl-activating enzyme (AAE) consensus motif; other site 483219003979 putative AMP binding site [chemical binding]; other site 483219003980 putative active site [active] 483219003981 putative CoA binding site [chemical binding]; other site 483219003982 Predicted transcriptional regulator [Transcription]; Region: COG2378 483219003983 HTH domain; Region: HTH_11; pfam08279 483219003984 WYL domain; Region: WYL; pfam13280 483219003985 Protein of unknown function (DUF1761); Region: DUF1761; pfam08570 483219003986 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR3; cd08275 483219003987 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 483219003988 putative NAD(P) binding site [chemical binding]; other site 483219003989 Lipase (class 2); Region: Lipase_2; pfam01674 483219003990 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 483219003991 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 483219003992 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 483219003993 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 483219003994 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 483219003995 acyl-activating enzyme (AAE) consensus motif; other site 483219003996 putative AMP binding site [chemical binding]; other site 483219003997 putative active site [active] 483219003998 putative CoA binding site [chemical binding]; other site 483219003999 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 483219004000 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 483219004001 dimer interface [polypeptide binding]; other site 483219004002 active site 483219004003 CoA binding pocket [chemical binding]; other site 483219004004 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 483219004005 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 483219004006 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 483219004007 Protein kinase domain; Region: Pkinase; pfam00069 483219004008 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219004009 active site 483219004010 ATP binding site [chemical binding]; other site 483219004011 substrate binding site [chemical binding]; other site 483219004012 activation loop (A-loop); other site 483219004013 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 483219004014 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 483219004015 non-specific DNA binding site [nucleotide binding]; other site 483219004016 salt bridge; other site 483219004017 sequence-specific DNA binding site [nucleotide binding]; other site 483219004018 Protein kinase domain; Region: Pkinase; pfam00069 483219004019 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 483219004020 active site 483219004021 ATP binding site [chemical binding]; other site 483219004022 substrate binding site [chemical binding]; other site 483219004023 activation loop (A-loop); other site 483219004024 Protein of unknown function (DUF2381); Region: DUF2381; pfam09544 483219004025 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 483219004026 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 483219004027 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 483219004028 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 483219004029 putative DNA binding site [nucleotide binding]; other site 483219004030 putative Zn2+ binding site [ion binding]; other site 483219004031 AsnC family; Region: AsnC_trans_reg; pfam01037 483219004032 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 483219004033 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 483219004034 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483219004035 homodimer interface [polypeptide binding]; other site 483219004036 catalytic residue [active] 483219004037 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 483219004038 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 483219004039 NAD(P) binding site [chemical binding]; other site 483219004040 active site 483219004041 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 483219004042 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 483219004043 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 483219004044 N-acetyl-D-glucosamine binding site [chemical binding]; other site 483219004045 catalytic residue [active] 483219004046 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 483219004047 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 483219004048 N-acetyl-D-glucosamine binding site [chemical binding]; other site 483219004049 catalytic residue [active] 483219004050 Subtilase family; Region: Peptidase_S8; pfam00082 483219004051 active site 483219004052 catalytic residues [active] 483219004053 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 483219004054 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219004055 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 483219004056 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 483219004057 DNA binding residues [nucleotide binding] 483219004058 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 483219004059 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 483219004060 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 483219004061 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 483219004062 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 483219004063 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 483219004064 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 483219004065 EamA-like transporter family; Region: EamA; pfam00892 483219004066 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 483219004067 active site residue [active] 483219004068 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 483219004069 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219004070 dimer interface [polypeptide binding]; other site 483219004071 phosphorylation site [posttranslational modification] 483219004072 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219004073 ATP binding site [chemical binding]; other site 483219004074 Mg2+ binding site [ion binding]; other site 483219004075 G-X-G motif; other site 483219004076 GAF domain; Region: GAF; cl17456 483219004077 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 483219004078 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219004079 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219004080 dimer interface [polypeptide binding]; other site 483219004081 phosphorylation site [posttranslational modification] 483219004082 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219004083 ATP binding site [chemical binding]; other site 483219004084 Mg2+ binding site [ion binding]; other site 483219004085 G-X-G motif; other site 483219004086 PAS domain S-box; Region: sensory_box; TIGR00229 483219004087 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219004088 putative active site [active] 483219004089 heme pocket [chemical binding]; other site 483219004090 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 483219004091 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219004092 putative active site [active] 483219004093 heme pocket [chemical binding]; other site 483219004094 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 483219004095 PAS domain; Region: PAS_8; pfam13188 483219004096 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219004097 dimer interface [polypeptide binding]; other site 483219004098 phosphorylation site [posttranslational modification] 483219004099 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219004100 ATP binding site [chemical binding]; other site 483219004101 Mg2+ binding site [ion binding]; other site 483219004102 G-X-G motif; other site 483219004103 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 483219004104 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219004105 active site 483219004106 phosphorylation site [posttranslational modification] 483219004107 intermolecular recognition site; other site 483219004108 dimerization interface [polypeptide binding]; other site 483219004109 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 483219004110 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 483219004111 metal ion-dependent adhesion site (MIDAS); other site 483219004112 Hypothetical protein; Provisional; Region: PHA03065 483219004113 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 483219004114 Penicillinase repressor; Region: Pencillinase_R; cl17580 483219004115 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 483219004116 4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087 483219004117 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 483219004118 Domain of unknown function (DUF4329); Region: DUF4329; pfam14220 483219004119 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 483219004120 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 483219004121 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 483219004122 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219004123 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 483219004124 Walker A motif; other site 483219004125 ATP binding site [chemical binding]; other site 483219004126 Walker B motif; other site 483219004127 arginine finger; other site 483219004128 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 483219004129 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 483219004130 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 483219004131 active site residue [active] 483219004132 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 483219004133 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 483219004134 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 483219004135 PAS domain; Region: PAS; smart00091 483219004136 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219004137 ATP binding site [chemical binding]; other site 483219004138 Mg2+ binding site [ion binding]; other site 483219004139 G-X-G motif; other site 483219004140 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 483219004141 TPR repeat; Region: TPR_11; pfam13414 483219004142 TPR motif; other site 483219004143 binding surface 483219004144 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 483219004145 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 483219004146 Potassium binding sites [ion binding]; other site 483219004147 Cesium cation binding sites [ion binding]; other site 483219004148 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219004149 dimerization interface [polypeptide binding]; other site 483219004150 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 483219004151 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 483219004152 dimer interface [polypeptide binding]; other site 483219004153 putative CheW interface [polypeptide binding]; other site 483219004154 cheY-homologous receiver domain; Region: REC; smart00448 483219004155 phosphorylation site [posttranslational modification] 483219004156 Hemerythrin-like domain; Region: Hr-like; cd12108 483219004157 Fe binding site [ion binding]; other site 483219004158 DNA binding domain, excisionase family; Region: excise; TIGR01764 483219004159 PIN domain; Region: PIN_3; pfam13470 483219004160 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219004161 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219004162 ATP binding site [chemical binding]; other site 483219004163 Mg2+ binding site [ion binding]; other site 483219004164 G-X-G motif; other site 483219004165 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 483219004166 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 483219004167 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 483219004168 Moco binding site; other site 483219004169 metal coordination site [ion binding]; other site 483219004170 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 483219004171 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 483219004172 DNA methylase; Region: N6_N4_Mtase; cl17433 483219004173 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 483219004174 EamA-like transporter family; Region: EamA; pfam00892 483219004175 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219004176 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219004177 ATP binding site [chemical binding]; other site 483219004178 Mg2+ binding site [ion binding]; other site 483219004179 G-X-G motif; other site 483219004180 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219004181 Methyltransferase domain; Region: Methyltransf_23; pfam13489 483219004182 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 483219004183 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 483219004184 active site 483219004185 metal binding site [ion binding]; metal-binding site 483219004186 DNA binding site [nucleotide binding] 483219004187 P-loop containing region of AAA domain; Region: AAA_29; cl17516 483219004188 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 483219004189 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 483219004190 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 483219004191 putative acyl-acceptor binding pocket; other site 483219004192 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 483219004193 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 483219004194 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 483219004195 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 483219004196 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 483219004197 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 483219004198 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 483219004199 Scramblase; Region: Scramblase; pfam03803 483219004200 Cupin superfamily protein; Region: Cupin_4; pfam08007 483219004201 FOG: WD40 repeat [General function prediction only]; Region: COG2319 483219004202 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 483219004203 structural tetrad; other site 483219004204 HEAT repeats; Region: HEAT_2; pfam13646 483219004205 HEAT repeats; Region: HEAT_2; pfam13646 483219004206 HEAT repeats; Region: HEAT_2; pfam13646 483219004207 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 483219004208 WGR domain; Region: WGR; cl01581 483219004209 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 483219004210 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 483219004211 putative active site [active] 483219004212 putative NTP binding site [chemical binding]; other site 483219004213 putative nucleic acid binding site [nucleotide binding]; other site 483219004214 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 483219004215 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 483219004216 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 483219004217 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 483219004218 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 483219004219 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 483219004220 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 483219004221 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 483219004222 putative active site [active] 483219004223 catalytic triad [active] 483219004224 putative dimer interface [polypeptide binding]; other site 483219004225 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 483219004226 active site 483219004227 oxyanion hole [active] 483219004228 potential frameshift: common BLAST hit: gi|108757317|ref|YP_628414.1| chloride channel (ClC) family protein 483219004229 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 483219004230 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 483219004231 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 483219004232 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 483219004233 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 483219004234 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 483219004235 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 483219004236 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 483219004237 putative active site [active] 483219004238 putative metal binding site [ion binding]; other site 483219004239 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 483219004240 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 483219004241 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 483219004242 FAD binding pocket [chemical binding]; other site 483219004243 FAD binding motif [chemical binding]; other site 483219004244 phosphate binding motif [ion binding]; other site 483219004245 beta-alpha-beta structure motif; other site 483219004246 NAD binding pocket [chemical binding]; other site 483219004247 Cytochrome c; Region: Cytochrom_C; pfam00034 483219004248 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 483219004249 active site 483219004250 Protein of unknown function (DUF1688); Region: DUF1688; pfam07958 483219004251 hypothetical protein; Validated; Region: PRK07198 483219004252 GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471 483219004253 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 483219004254 dimerization interface [polypeptide binding]; other site 483219004255 active site 483219004256 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 483219004257 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 483219004258 tetrameric interface [polypeptide binding]; other site 483219004259 NAD binding site [chemical binding]; other site 483219004260 catalytic residues [active] 483219004261 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 483219004262 Transcriptional regulator [Transcription]; Region: LysR; COG0583 483219004263 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 483219004264 LysR substrate binding domain; Region: LysR_substrate; pfam03466 483219004265 dimerization interface [polypeptide binding]; other site 483219004266 Predicted lipoprotein of unknown function (DUF2380); Region: DUF2380; pfam09533 483219004267 Protein of unknown function (Gmx_para_CXXCG); Region: Gmx_para_CXXCG; cl15282 483219004268 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219004269 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219004270 active site 483219004271 ATP binding site [chemical binding]; other site 483219004272 substrate binding site [chemical binding]; other site 483219004273 activation loop (A-loop); other site 483219004274 Tetratricopeptide repeat; Region: TPR_12; pfam13424 483219004275 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219004276 TPR motif; other site 483219004277 binding surface 483219004278 Tetratricopeptide repeat; Region: TPR_12; pfam13424 483219004279 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 483219004280 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 483219004281 phosphopeptide binding site; other site 483219004282 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 483219004283 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219004284 Walker A motif; other site 483219004285 ATP binding site [chemical binding]; other site 483219004286 Walker B motif; other site 483219004287 arginine finger; other site 483219004288 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 483219004289 putative active site [active] 483219004290 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 483219004291 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 483219004292 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 483219004293 N-acetyl-D-glucosamine binding site [chemical binding]; other site 483219004294 catalytic residue [active] 483219004295 Protein of unknown function (DUF770); Region: DUF770; cl01402 483219004296 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 483219004297 Protein of unknown function (DUF877); Region: DUF877; pfam05943 483219004298 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 483219004299 Coenzyme A binding pocket [chemical binding]; other site 483219004300 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 483219004301 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 483219004302 putative active site [active] 483219004303 catalytic site [active] 483219004304 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 483219004305 putative active site [active] 483219004306 catalytic site [active] 483219004307 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 483219004308 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 483219004309 FtsX-like permease family; Region: FtsX; pfam02687 483219004310 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 483219004311 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 483219004312 FtsX-like permease family; Region: FtsX; pfam02687 483219004313 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483219004314 putative substrate translocation pore; other site 483219004315 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483219004316 Phosphotransferase enzyme family; Region: APH; pfam01636 483219004317 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 483219004318 active site 483219004319 substrate binding site [chemical binding]; other site 483219004320 ATP binding site [chemical binding]; other site 483219004321 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 483219004322 PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815 483219004323 PA/protease or protease-like domain interface [polypeptide binding]; other site 483219004324 M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883 483219004325 Peptidase family M28; Region: Peptidase_M28; pfam04389 483219004326 metal binding site [ion binding]; metal-binding site 483219004327 Predicted lipoprotein of unknown function (DUF2380); Region: DUF2380; cl15289 483219004328 Uncharacterized conserved protein [Function unknown]; Region: COG1479 483219004329 Protein of unknown function DUF262; Region: DUF262; pfam03235 483219004330 Protein of unknown function DUF262; Region: DUF262; pfam03235 483219004331 HipA N-terminal domain; Region: Couple_hipA; pfam13657 483219004332 HipA-like N-terminal domain; Region: HipA_N; pfam07805 483219004333 HipA-like C-terminal domain; Region: HipA_C; pfam07804 483219004334 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219004335 putative active site [active] 483219004336 heme pocket [chemical binding]; other site 483219004337 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 483219004338 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 483219004339 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219004340 putative active site [active] 483219004341 heme pocket [chemical binding]; other site 483219004342 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 483219004343 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219004344 ATP binding site [chemical binding]; other site 483219004345 Mg2+ binding site [ion binding]; other site 483219004346 G-X-G motif; other site 483219004347 Response regulator receiver domain; Region: Response_reg; pfam00072 483219004348 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219004349 active site 483219004350 phosphorylation site [posttranslational modification] 483219004351 intermolecular recognition site; other site 483219004352 dimerization interface [polypeptide binding]; other site 483219004353 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 483219004354 Domain of unknown function DUF59; Region: DUF59; cl00941 483219004355 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 483219004356 putative C-terminal domain interface [polypeptide binding]; other site 483219004357 putative GSH binding site (G-site) [chemical binding]; other site 483219004358 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 483219004359 putative dimer interface [polypeptide binding]; other site 483219004360 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 483219004361 dimer interface [polypeptide binding]; other site 483219004362 N-terminal domain interface [polypeptide binding]; other site 483219004363 putative substrate binding pocket (H-site) [chemical binding]; other site 483219004364 Phosphotransferase enzyme family; Region: APH; pfam01636 483219004365 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 483219004366 putative active site [active] 483219004367 putative substrate binding site [chemical binding]; other site 483219004368 ATP binding site [chemical binding]; other site 483219004369 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 483219004370 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 483219004371 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 483219004372 active site 483219004373 short chain dehydrogenase; Provisional; Region: PRK06949 483219004374 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 483219004375 NAD(P) binding site [chemical binding]; other site 483219004376 active site 483219004377 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 483219004378 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 483219004379 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 483219004380 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483219004381 putative substrate translocation pore; other site 483219004382 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 483219004383 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 483219004384 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 483219004385 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 483219004386 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 483219004387 ATP-grasp domain; Region: ATP-grasp_4; cl17255 483219004388 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 483219004389 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 483219004390 carboxyltransferase (CT) interaction site; other site 483219004391 biotinylation site [posttranslational modification]; other site 483219004392 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 483219004393 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 483219004394 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 483219004395 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 483219004396 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 483219004397 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 483219004398 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 483219004399 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 483219004400 NAD(P) binding site [chemical binding]; other site 483219004401 active site 483219004402 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330 483219004403 putative ADP-ribose binding site [chemical binding]; other site 483219004404 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 483219004405 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 483219004406 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 483219004407 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 483219004408 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 483219004409 Amidohydrolase; Region: Amidohydro_4; pfam13147 483219004410 active site 483219004411 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 483219004412 CoenzymeA binding site [chemical binding]; other site 483219004413 subunit interaction site [polypeptide binding]; other site 483219004414 PHB binding site; other site 483219004415 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 483219004416 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 483219004417 CoenzymeA binding site [chemical binding]; other site 483219004418 subunit interaction site [polypeptide binding]; other site 483219004419 PHB binding site; other site 483219004420 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 483219004421 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219004422 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219004423 active site 483219004424 ATP binding site [chemical binding]; other site 483219004425 substrate binding site [chemical binding]; other site 483219004426 activation loop (A-loop); other site 483219004427 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 483219004428 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 483219004429 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 483219004430 RNA polymerase sigma-70 factor, Myxococcales family 1; Region: Sig-70_gmx1; TIGR03001 483219004431 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 483219004432 DNA binding residues [nucleotide binding] 483219004433 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 483219004434 hypothetical protein; Reviewed; Region: PRK09588 483219004435 Myxococcus xanthus paralogous domain TIGR02266; Region: gmx_TIGR02266 483219004436 Cupin domain; Region: Cupin_2; cl17218 483219004437 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 483219004438 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219004439 PAS domain; Region: PAS_9; pfam13426 483219004440 putative active site [active] 483219004441 heme pocket [chemical binding]; other site 483219004442 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 483219004443 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 483219004444 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219004445 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219004446 ATP binding site [chemical binding]; other site 483219004447 Mg2+ binding site [ion binding]; other site 483219004448 G-X-G motif; other site 483219004449 polyphosphate kinase; Provisional; Region: PRK05443 483219004450 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 483219004451 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 483219004452 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 483219004453 putative domain interface [polypeptide binding]; other site 483219004454 putative active site [active] 483219004455 catalytic site [active] 483219004456 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 483219004457 putative domain interface [polypeptide binding]; other site 483219004458 putative active site [active] 483219004459 catalytic site [active] 483219004460 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 483219004461 Uncharacterized conserved protein [Function unknown]; Region: COG4850 483219004462 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 483219004463 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 483219004464 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 483219004465 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 483219004466 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 483219004467 conserved hypothetical protein; Region: TIGR02270 483219004468 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 483219004469 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 483219004470 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 483219004471 Glucose dehydrogenase; Region: glucose_DH; cd08230 483219004472 NADP binding site [chemical binding]; other site 483219004473 catalytic Zn binding site [ion binding]; other site 483219004474 structural Zn binding site [ion binding]; other site 483219004475 dimer interface [polypeptide binding]; other site 483219004476 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 483219004477 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 483219004478 Walker A/P-loop; other site 483219004479 ATP binding site [chemical binding]; other site 483219004480 Q-loop/lid; other site 483219004481 ABC transporter signature motif; other site 483219004482 Walker B; other site 483219004483 D-loop; other site 483219004484 H-loop/switch region; other site 483219004485 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 483219004486 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483219004487 dimer interface [polypeptide binding]; other site 483219004488 conserved gate region; other site 483219004489 putative PBP binding loops; other site 483219004490 ABC-ATPase subunit interface; other site 483219004491 NMT1-like family; Region: NMT1_2; pfam13379 483219004492 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 483219004493 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 483219004494 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219004495 binding surface 483219004496 Tetratricopeptide repeat; Region: TPR_16; pfam13432 483219004497 TPR motif; other site 483219004498 NYN domain; Region: NYN; pfam01936 483219004499 putative metal binding site [ion binding]; other site 483219004500 Uncharacterized conserved protein [Function unknown]; Region: COG1432 483219004501 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 483219004502 Flagellin N-methylase; Region: FliB; pfam03692 483219004503 VacB and RNase II family 3'-5' exoribonucleases; Region: 3_prime_RNase; TIGR00358 483219004504 RNB domain; Region: RNB; pfam00773 483219004505 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 483219004506 RNA binding site [nucleotide binding]; other site 483219004507 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 483219004508 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219004509 active site 483219004510 ATP binding site [chemical binding]; other site 483219004511 substrate binding site [chemical binding]; other site 483219004512 activation loop (A-loop); other site 483219004513 PEGA domain; Region: PEGA; pfam08308 483219004514 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 483219004515 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219004516 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219004517 active site 483219004518 ATP binding site [chemical binding]; other site 483219004519 substrate binding site [chemical binding]; other site 483219004520 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 483219004521 substrate binding site [chemical binding]; other site 483219004522 activation loop (A-loop); other site 483219004523 activation loop (A-loop); other site 483219004524 PEGA domain; Region: PEGA; pfam08308 483219004525 glutathione synthetase; Provisional; Region: PRK05246 483219004526 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 483219004527 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 483219004528 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 483219004529 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 483219004530 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775 483219004531 HipA-like N-terminal domain; Region: HipA_N; pfam07805 483219004532 HipA-like C-terminal domain; Region: HipA_C; pfam07804 483219004533 HipA N-terminal domain; Region: Couple_hipA; cl11853 483219004534 HipA-like N-terminal domain; Region: HipA_N; pfam07805 483219004535 HipA-like C-terminal domain; Region: HipA_C; pfam07804 483219004536 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 483219004537 Nuclease-related domain; Region: NERD; pfam08378 483219004538 Part of AAA domain; Region: AAA_19; pfam13245 483219004539 Family description; Region: UvrD_C_2; pfam13538 483219004540 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 483219004541 active site 483219004542 Int/Topo IB signature motif; other site 483219004543 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 483219004544 non-specific DNA binding site [nucleotide binding]; other site 483219004545 salt bridge; other site 483219004546 sequence-specific DNA binding site [nucleotide binding]; other site 483219004547 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 483219004548 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219004549 S-adenosylmethionine binding site [chemical binding]; other site 483219004550 DoxX; Region: DoxX; pfam07681 483219004551 Tetratricopeptide repeat; Region: TPR_16; pfam13432 483219004552 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 483219004553 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 483219004554 putative active site [active] 483219004555 putative metal binding site [ion binding]; other site 483219004556 H+ Antiporter protein; Region: 2A0121; TIGR00900 483219004557 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483219004558 putative substrate translocation pore; other site 483219004559 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 483219004560 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 483219004561 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 483219004562 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 483219004563 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 483219004564 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 483219004565 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 483219004566 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 483219004567 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 483219004568 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 483219004569 FOG: CBS domain [General function prediction only]; Region: COG0517 483219004570 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 483219004571 HEAT repeats; Region: HEAT_2; pfam13646 483219004572 HEAT repeats; Region: HEAT_2; pfam13646 483219004573 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 483219004574 DnaA N-terminal domain; Region: DnaA_N; pfam11638 483219004575 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219004576 Walker A motif; other site 483219004577 ATP binding site [chemical binding]; other site 483219004578 Walker B motif; other site 483219004579 arginine finger; other site 483219004580 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 483219004581 DnaA box-binding interface [nucleotide binding]; other site 483219004582 HEAT repeats; Region: HEAT_2; pfam13646 483219004583 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 483219004584 Ribonuclease P; Region: Ribonuclease_P; pfam00825 483219004585 Haemolytic domain; Region: Haemolytic; pfam01809 483219004586 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 483219004587 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 483219004588 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 483219004589 G-X-X-G motif; other site 483219004590 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 483219004591 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 483219004592 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 483219004593 G1 box; other site 483219004594 GTP/Mg2+ binding site [chemical binding]; other site 483219004595 G2 box; other site 483219004596 Switch I region; other site 483219004597 G3 box; other site 483219004598 Switch II region; other site 483219004599 G4 box; other site 483219004600 G5 box; other site 483219004601 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 483219004602 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 483219004603 putative active site [active] 483219004604 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 483219004605 putative hydrophobic ligand binding site [chemical binding]; other site 483219004606 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 483219004607 putative DNA binding site [nucleotide binding]; other site 483219004608 putative Zn2+ binding site [ion binding]; other site 483219004609 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 483219004610 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 483219004611 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 483219004612 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 483219004613 tandem repeat interface [polypeptide binding]; other site 483219004614 oligomer interface [polypeptide binding]; other site 483219004615 active site residues [active] 483219004616 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 483219004617 tandem repeat interface [polypeptide binding]; other site 483219004618 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 483219004619 oligomer interface [polypeptide binding]; other site 483219004620 active site residues [active] 483219004621 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 483219004622 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 483219004623 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 483219004624 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 483219004625 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 483219004626 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 483219004627 PGAP1-like protein; Region: PGAP1; pfam07819 483219004628 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 483219004629 repeat-companion domain TIGR02996; Region: rpt_mate_G_obs 483219004630 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 483219004631 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483219004632 putative substrate translocation pore; other site 483219004633 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 483219004634 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 483219004635 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 483219004636 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 483219004637 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 483219004638 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 483219004639 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 483219004640 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 483219004641 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 483219004642 P-loop; other site 483219004643 Magnesium ion binding site [ion binding]; other site 483219004644 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 483219004645 Magnesium ion binding site [ion binding]; other site 483219004646 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 483219004647 ParB-like nuclease domain; Region: ParB; smart00470 483219004648 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 483219004649 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 483219004650 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 483219004651 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 483219004652 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 483219004653 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 483219004654 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 483219004655 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 483219004656 sequence-specific DNA binding site [nucleotide binding]; other site 483219004657 salt bridge; other site 483219004658 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 483219004659 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 483219004660 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 483219004661 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 483219004662 Cl- selectivity filter; other site 483219004663 Cl- binding residues [ion binding]; other site 483219004664 pore gating glutamate residue; other site 483219004665 alanine dehydrogenase; Validated; Region: PRK06046 483219004666 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 483219004667 Domain of unknown function (DUF4326); Region: DUF4326; pfam14216 483219004668 Histone methylation protein DOT1; Region: DOT1; pfam08123 483219004669 Methyltransferase domain; Region: Methyltransf_31; pfam13847 483219004670 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 483219004671 conserved hypothetical protein; Region: TIGR02270 483219004672 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 483219004673 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 483219004674 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 483219004675 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 483219004676 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 483219004677 Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891 483219004678 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 483219004679 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 483219004680 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 483219004681 trimer interface [polypeptide binding]; other site 483219004682 active site 483219004683 substrate binding site [chemical binding]; other site 483219004684 CoA binding site [chemical binding]; other site 483219004685 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 483219004686 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 483219004687 active site 483219004688 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 483219004689 putative ADP-binding pocket [chemical binding]; other site 483219004690 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 483219004691 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219004692 Response regulator receiver domain; Region: Response_reg; pfam00072 483219004693 active site 483219004694 phosphorylation site [posttranslational modification] 483219004695 intermolecular recognition site; other site 483219004696 dimerization interface [polypeptide binding]; other site 483219004697 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 483219004698 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219004699 putative active site [active] 483219004700 heme pocket [chemical binding]; other site 483219004701 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219004702 dimer interface [polypeptide binding]; other site 483219004703 phosphorylation site [posttranslational modification] 483219004704 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219004705 ATP binding site [chemical binding]; other site 483219004706 Mg2+ binding site [ion binding]; other site 483219004707 G-X-G motif; other site 483219004708 O-Antigen ligase; Region: Wzy_C; pfam04932 483219004709 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 483219004710 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 483219004711 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 483219004712 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219004713 active site 483219004714 phosphorylation site [posttranslational modification] 483219004715 intermolecular recognition site; other site 483219004716 dimerization interface [polypeptide binding]; other site 483219004717 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219004718 Walker A motif; other site 483219004719 ATP binding site [chemical binding]; other site 483219004720 Walker B motif; other site 483219004721 arginine finger; other site 483219004722 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 483219004723 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 483219004724 dimerization interface [polypeptide binding]; other site 483219004725 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219004726 dimer interface [polypeptide binding]; other site 483219004727 phosphorylation site [posttranslational modification] 483219004728 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219004729 ATP binding site [chemical binding]; other site 483219004730 G-X-G motif; other site 483219004731 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 483219004732 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 483219004733 HlyD family secretion protein; Region: HlyD_3; pfam13437 483219004734 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 483219004735 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 483219004736 RibD C-terminal domain; Region: RibD_C; cl17279 483219004737 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 483219004738 Acyltransferase family; Region: Acyl_transf_3; pfam01757 483219004739 Ornithine cyclodeaminase/mu-crystallin family; Region: OCD_Mu_crystall; pfam02423 483219004740 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 483219004741 GYD domain; Region: GYD; cl01743 483219004742 acyl-CoA synthetase; Validated; Region: PRK05850 483219004743 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 483219004744 acyl-activating enzyme (AAE) consensus motif; other site 483219004745 active site 483219004746 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 483219004747 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 483219004748 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 483219004749 active site 483219004750 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 483219004751 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 483219004752 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 483219004753 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 483219004754 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 483219004755 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 483219004756 putative NADP binding site [chemical binding]; other site 483219004757 KR domain; Region: KR; pfam08659 483219004758 active site 483219004759 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 483219004760 Condensation domain; Region: Condensation; pfam00668 483219004761 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219004762 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219004763 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 483219004764 acyl-activating enzyme (AAE) consensus motif; other site 483219004765 AMP binding site [chemical binding]; other site 483219004766 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219004767 Condensation domain; Region: Condensation; pfam00668 483219004768 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219004769 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219004770 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 483219004771 acyl-activating enzyme (AAE) consensus motif; other site 483219004772 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 483219004773 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 483219004774 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 483219004775 AMP binding site [chemical binding]; other site 483219004776 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219004777 Thioesterase domain; Region: Thioesterase; pfam00975 483219004778 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219004779 S-adenosylmethionine binding site [chemical binding]; other site 483219004780 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 483219004781 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 483219004782 DXD motif; other site 483219004783 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 483219004784 Response regulator receiver domain; Region: Response_reg; pfam00072 483219004785 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219004786 active site 483219004787 phosphorylation site [posttranslational modification] 483219004788 intermolecular recognition site; other site 483219004789 dimerization interface [polypeptide binding]; other site 483219004790 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 483219004791 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 483219004792 SLBB domain; Region: SLBB; pfam10531 483219004793 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 483219004794 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 483219004795 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 483219004796 Bacterial sugar transferase; Region: Bac_transf; pfam02397 483219004797 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 483219004798 Walker A motif; other site 483219004799 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 483219004800 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 483219004801 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 483219004802 dimer interface [polypeptide binding]; other site 483219004803 putative functional site; other site 483219004804 putative MPT binding site; other site 483219004805 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 483219004806 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 483219004807 GTP binding site; other site 483219004808 Protein of unknown function (Gmx_para_CXXCG); Region: Gmx_para_CXXCG; cl15282 483219004809 Protein of unknown function (DUF2381); Region: DUF2381; pfam09544 483219004810 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219004811 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219004812 active site 483219004813 ATP binding site [chemical binding]; other site 483219004814 substrate binding site [chemical binding]; other site 483219004815 activation loop (A-loop); other site 483219004816 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 483219004817 active site 483219004818 ATP binding site [chemical binding]; other site 483219004819 substrate binding site [chemical binding]; other site 483219004820 activation loop (A-loop); other site 483219004821 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 483219004822 Myxococcales-restricted protein, TIGR02265 family; Region: Mxa_TIGR02265 483219004823 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 483219004824 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 483219004825 Proline dehydrogenase; Region: Pro_dh; cl03282 483219004826 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 483219004827 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 483219004828 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 483219004829 putative acyl-acceptor binding pocket; other site 483219004830 Hemerythrin-like domain; Region: Hr-like; cd12108 483219004831 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 483219004832 Predicted ATPase [General function prediction only]; Region: COG5293 483219004833 Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088 483219004834 GAF domain; Region: GAF_2; pfam13185 483219004835 GAF domain; Region: GAF; cl17456 483219004836 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219004837 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219004838 dimer interface [polypeptide binding]; other site 483219004839 phosphorylation site [posttranslational modification] 483219004840 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219004841 ATP binding site [chemical binding]; other site 483219004842 Mg2+ binding site [ion binding]; other site 483219004843 G-X-G motif; other site 483219004844 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 483219004845 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 483219004846 ligand binding site [chemical binding]; other site 483219004847 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219004848 Response regulator receiver domain; Region: Response_reg; pfam00072 483219004849 active site 483219004850 phosphorylation site [posttranslational modification] 483219004851 intermolecular recognition site; other site 483219004852 dimerization interface [polypeptide binding]; other site 483219004853 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 483219004854 cyclase homology domain; Region: CHD; cd07302 483219004855 nucleotidyl binding site; other site 483219004856 metal binding site [ion binding]; metal-binding site 483219004857 dimer interface [polypeptide binding]; other site 483219004858 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 483219004859 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 483219004860 Ligand Binding Site [chemical binding]; other site 483219004861 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 483219004862 Ligand Binding Site [chemical binding]; other site 483219004863 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 483219004864 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 483219004865 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219004866 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219004867 ATP binding site [chemical binding]; other site 483219004868 Mg2+ binding site [ion binding]; other site 483219004869 G-X-G motif; other site 483219004870 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 483219004871 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 483219004872 ligand binding site [chemical binding]; other site 483219004873 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219004874 Response regulator receiver domain; Region: Response_reg; pfam00072 483219004875 active site 483219004876 phosphorylation site [posttranslational modification] 483219004877 intermolecular recognition site; other site 483219004878 dimerization interface [polypeptide binding]; other site 483219004879 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 483219004880 cyclase homology domain; Region: CHD; cd07302 483219004881 nucleotidyl binding site; other site 483219004882 metal binding site [ion binding]; metal-binding site 483219004883 dimer interface [polypeptide binding]; other site 483219004884 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 483219004885 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 483219004886 Ligand Binding Site [chemical binding]; other site 483219004887 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 483219004888 Ligand Binding Site [chemical binding]; other site 483219004889 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 483219004890 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 483219004891 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 483219004892 Cu(I) binding site [ion binding]; other site 483219004893 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 483219004894 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 483219004895 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 483219004896 Predicted chitinase [General function prediction only]; Region: COG3179 483219004897 catalytic residue [active] 483219004898 SnoaL-like domain; Region: SnoaL_2; pfam12680 483219004899 YceI-like domain; Region: YceI; pfam04264 483219004900 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 483219004901 iron-sulfur cluster [ion binding]; other site 483219004902 [2Fe-2S] cluster binding site [ion binding]; other site 483219004903 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 483219004904 iron-sulfur cluster [ion binding]; other site 483219004905 [2Fe-2S] cluster binding site [ion binding]; other site 483219004906 FOG: CBS domain [General function prediction only]; Region: COG0517 483219004907 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 483219004908 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 483219004909 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 483219004910 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 483219004911 DTAP/Switch II; other site 483219004912 ornithine--oxo-acid transaminase; Reviewed; Region: rocD; PRK00854 483219004913 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 483219004914 inhibitor-cofactor binding pocket; inhibition site 483219004915 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483219004916 catalytic residue [active] 483219004917 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219004918 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219004919 active site 483219004920 ATP binding site [chemical binding]; other site 483219004921 substrate binding site [chemical binding]; other site 483219004922 activation loop (A-loop); other site 483219004923 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219004924 active site 483219004925 ATP binding site [chemical binding]; other site 483219004926 substrate binding site [chemical binding]; other site 483219004927 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 483219004928 substrate binding site [chemical binding]; other site 483219004929 activation loop (A-loop); other site 483219004930 activation loop (A-loop); other site 483219004931 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 483219004932 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 483219004933 sequence-specific DNA binding site [nucleotide binding]; other site 483219004934 salt bridge; other site 483219004935 GAF domain; Region: GAF_3; pfam13492 483219004936 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219004937 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219004938 dimer interface [polypeptide binding]; other site 483219004939 phosphorylation site [posttranslational modification] 483219004940 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219004941 ATP binding site [chemical binding]; other site 483219004942 Mg2+ binding site [ion binding]; other site 483219004943 G-X-G motif; other site 483219004944 Response regulator receiver domain; Region: Response_reg; pfam00072 483219004945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219004946 active site 483219004947 phosphorylation site [posttranslational modification] 483219004948 intermolecular recognition site; other site 483219004949 dimerization interface [polypeptide binding]; other site 483219004950 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 483219004951 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219004952 putative active site [active] 483219004953 heme pocket [chemical binding]; other site 483219004954 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219004955 dimer interface [polypeptide binding]; other site 483219004956 phosphorylation site [posttranslational modification] 483219004957 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219004958 ATP binding site [chemical binding]; other site 483219004959 Mg2+ binding site [ion binding]; other site 483219004960 G-X-G motif; other site 483219004961 PAS domain; Region: PAS_9; pfam13426 483219004962 PAS domain S-box; Region: sensory_box; TIGR00229 483219004963 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219004964 putative active site [active] 483219004965 heme pocket [chemical binding]; other site 483219004966 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219004967 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 483219004968 dimer interface [polypeptide binding]; other site 483219004969 phosphorylation site [posttranslational modification] 483219004970 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219004971 ATP binding site [chemical binding]; other site 483219004972 Mg2+ binding site [ion binding]; other site 483219004973 G-X-G motif; other site 483219004974 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 483219004975 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 483219004976 active site 483219004977 dimerization interface [polypeptide binding]; other site 483219004978 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219004979 phosphorylation site [posttranslational modification] 483219004980 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219004981 ATP binding site [chemical binding]; other site 483219004982 Mg2+ binding site [ion binding]; other site 483219004983 G-X-G motif; other site 483219004984 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 483219004985 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219004986 phosphorylation site [posttranslational modification] 483219004987 intermolecular recognition site; other site 483219004988 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 483219004989 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219004990 active site 483219004991 phosphorylation site [posttranslational modification] 483219004992 intermolecular recognition site; other site 483219004993 dimerization interface [polypeptide binding]; other site 483219004994 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 483219004995 active site 483219004996 I-site; other site 483219004997 Uncharacterized conserved protein [Function unknown]; Region: COG5276 483219004998 LVIVD repeat; Region: LVIVD; pfam08309 483219004999 Uncharacterized conserved protein [Function unknown]; Region: COG5276 483219005000 Uncharacterized conserved protein [Function unknown]; Region: COG5276 483219005001 LVIVD repeat; Region: LVIVD; pfam08309 483219005002 LVIVD repeat; Region: LVIVD; pfam08309 483219005003 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 483219005004 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 483219005005 RNA binding site [nucleotide binding]; other site 483219005006 active site 483219005007 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 483219005008 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 483219005009 TPP-binding site [chemical binding]; other site 483219005010 dimer interface [polypeptide binding]; other site 483219005011 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 483219005012 PYR/PP interface [polypeptide binding]; other site 483219005013 dimer interface [polypeptide binding]; other site 483219005014 TPP binding site [chemical binding]; other site 483219005015 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 483219005016 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 483219005017 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 483219005018 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219005019 Walker A motif; other site 483219005020 ATP binding site [chemical binding]; other site 483219005021 Walker B motif; other site 483219005022 arginine finger; other site 483219005023 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 483219005024 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 483219005025 active site 483219005026 Myxococcales-restricted protein, TIGR02265 family; Region: Mxa_TIGR02265 483219005027 SnoaL-like domain; Region: SnoaL_2; pfam12680 483219005028 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 483219005029 active site 483219005030 catalytic residues [active] 483219005031 metal binding site [ion binding]; metal-binding site 483219005032 SlyX; Region: SlyX; pfam04102 483219005033 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 483219005034 binding surface 483219005035 TPR motif; other site 483219005036 Tetratricopeptide repeat; Region: TPR_12; pfam13424 483219005037 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219005038 binding surface 483219005039 TPR motif; other site 483219005040 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 483219005041 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 483219005042 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 483219005043 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 483219005044 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 483219005045 active site 483219005046 catalytic residues [active] 483219005047 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 483219005048 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538 483219005049 PA/protease or protease-like domain interface [polypeptide binding]; other site 483219005050 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 483219005051 catalytic residues [active] 483219005052 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 483219005053 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 483219005054 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 483219005055 DNA binding residues [nucleotide binding] 483219005056 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 483219005057 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 483219005058 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 483219005059 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 483219005060 putative NAD(P) binding site [chemical binding]; other site 483219005061 putative substrate binding site [chemical binding]; other site 483219005062 catalytic Zn binding site [ion binding]; other site 483219005063 structural Zn binding site [ion binding]; other site 483219005064 dimer interface [polypeptide binding]; other site 483219005065 Transcriptional regulator [Transcription]; Region: LysR; COG0583 483219005066 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 483219005067 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 483219005068 putative effector binding pocket; other site 483219005069 putative dimerization interface [polypeptide binding]; other site 483219005070 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 483219005071 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 483219005072 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 483219005073 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 483219005074 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 483219005075 Penicillinase repressor; Region: Pencillinase_R; pfam03965 483219005076 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 483219005077 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 483219005078 N-acetyl-D-glucosamine binding site [chemical binding]; other site 483219005079 catalytic residue [active] 483219005080 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 483219005081 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 483219005082 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 483219005083 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 483219005084 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 483219005085 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 483219005086 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 483219005087 Transcriptional regulator [Transcription]; Region: LysR; COG0583 483219005088 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 483219005089 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 483219005090 dimerization interface [polypeptide binding]; other site 483219005091 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 483219005092 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 483219005093 active site 483219005094 short chain dehydrogenase; Provisional; Region: PRK08278 483219005095 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 483219005096 NAD(P) binding site [chemical binding]; other site 483219005097 homodimer interface [polypeptide binding]; other site 483219005098 active site 483219005099 MltA specific insert domain; Region: MltA; smart00925 483219005100 3D domain; Region: 3D; pfam06725 483219005101 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 483219005102 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 483219005103 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 483219005104 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 483219005105 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 483219005106 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 483219005107 Thioredoxin; Region: Thioredoxin_4; pfam13462 483219005108 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 483219005109 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 483219005110 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 483219005111 Fatty acid desaturase; Region: FA_desaturase; pfam00487 483219005112 putative di-iron ligands [ion binding]; other site 483219005113 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 483219005114 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 483219005115 Cytochrome P450; Region: p450; cl12078 483219005116 ERp29 and ERp38, C-terminal domain; composed of the protein disulfide isomerase (PDI)-like proteins ERp29 and ERp38. ERp29 (also called ERp28) is a ubiquitous endoplasmic reticulum (ER)-resident protein expressed in high levels in secretory cells. It...; Region: ERp29c; cl02782 483219005117 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 483219005118 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 483219005119 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483219005120 dimer interface [polypeptide binding]; other site 483219005121 conserved gate region; other site 483219005122 putative PBP binding loops; other site 483219005123 ABC-ATPase subunit interface; other site 483219005124 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 483219005125 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483219005126 dimer interface [polypeptide binding]; other site 483219005127 conserved gate region; other site 483219005128 putative PBP binding loops; other site 483219005129 ABC-ATPase subunit interface; other site 483219005130 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219005131 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219005132 active site 483219005133 ATP binding site [chemical binding]; other site 483219005134 substrate binding site [chemical binding]; other site 483219005135 activation loop (A-loop); other site 483219005136 AAA ATPase domain; Region: AAA_16; pfam13191 483219005137 RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984 483219005138 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 483219005139 DNA binding residues [nucleotide binding] 483219005140 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219005141 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219005142 active site 483219005143 ATP binding site [chemical binding]; other site 483219005144 substrate binding site [chemical binding]; other site 483219005145 activation loop (A-loop); other site 483219005146 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 483219005147 active site 483219005148 NTP binding site [chemical binding]; other site 483219005149 metal binding triad [ion binding]; metal-binding site 483219005150 CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436 483219005151 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09679 483219005152 CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577 483219005153 CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700 483219005154 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075 483219005155 CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440 483219005156 CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cd09749 483219005157 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 483219005158 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219005159 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 483219005160 Walker A motif; other site 483219005161 ATP binding site [chemical binding]; other site 483219005162 Walker B motif; other site 483219005163 arginine finger; other site 483219005164 hypothetical protein; Provisional; Region: yieM; PRK10997 483219005165 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 483219005166 metal ion-dependent adhesion site (MIDAS); other site 483219005167 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 483219005168 SNF2 Helicase protein; Region: DUF3670; pfam12419 483219005169 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 483219005170 ATP binding site [chemical binding]; other site 483219005171 putative Mg++ binding site [ion binding]; other site 483219005172 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 483219005173 nucleotide binding region [chemical binding]; other site 483219005174 ATP-binding site [chemical binding]; other site 483219005175 Uncharacterized conserved protein [Function unknown]; Region: COG4279 483219005176 SWIM zinc finger; Region: SWIM; pfam04434 483219005177 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 483219005178 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 483219005179 active site 483219005180 catalytic tetrad [active] 483219005181 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 483219005182 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219005183 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219005184 active site 483219005185 ATP binding site [chemical binding]; other site 483219005186 substrate binding site [chemical binding]; other site 483219005187 activation loop (A-loop); other site 483219005188 Myxococcus xanthus paralogous family TIGR02268; Region: TIGR02268 483219005189 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09703 483219005190 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 483219005191 NADH(P)-binding; Region: NAD_binding_10; pfam13460 483219005192 NAD(P) binding site [chemical binding]; other site 483219005193 active site 483219005194 Myxococcales-restricted protein, TIGR02265 family; Region: Mxa_TIGR02265 483219005195 Uncharacterized ABC-type transport system, permease components [General function prediction only]; Region: COG3932 483219005196 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219005197 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219005198 active site 483219005199 ATP binding site [chemical binding]; other site 483219005200 substrate binding site [chemical binding]; other site 483219005201 activation loop (A-loop); other site 483219005202 AAA ATPase domain; Region: AAA_16; pfam13191 483219005203 Predicted ATPase [General function prediction only]; Region: COG3899 483219005204 Trm112p-like protein; Region: Trm112p; pfam03966 483219005205 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219005206 S-adenosylmethionine binding site [chemical binding]; other site 483219005207 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 483219005208 classical (c) SDRs; Region: SDR_c; cd05233 483219005209 NAD(P) binding site [chemical binding]; other site 483219005210 active site 483219005211 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 483219005212 putative acyl-acceptor binding pocket; other site 483219005213 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 483219005214 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 483219005215 active site 483219005216 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 483219005217 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 483219005218 active site 483219005219 nucleophile elbow; other site 483219005220 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 483219005221 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 483219005222 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 483219005223 HlyD family secretion protein; Region: HlyD_3; pfam13437 483219005224 Outer membrane efflux protein; Region: OEP; pfam02321 483219005225 Outer membrane efflux protein; Region: OEP; pfam02321 483219005226 AAA domain; Region: AAA_23; pfam13476 483219005227 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219005228 Walker A/P-loop; other site 483219005229 ATP binding site [chemical binding]; other site 483219005230 AAA domain; Region: AAA_21; pfam13304 483219005231 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 483219005232 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 483219005233 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 483219005234 catalytic site [active] 483219005235 TAP-like protein; Region: Abhydrolase_4; pfam08386 483219005236 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 483219005237 conserved hypothetical protein; Region: TIGR02270 483219005238 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 483219005239 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 483219005240 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 483219005241 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 483219005242 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 483219005243 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 483219005244 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 483219005245 Walker A/P-loop; other site 483219005246 ATP binding site [chemical binding]; other site 483219005247 Q-loop/lid; other site 483219005248 ABC transporter signature motif; other site 483219005249 Walker B; other site 483219005250 D-loop; other site 483219005251 H-loop/switch region; other site 483219005252 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 483219005253 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 483219005254 Walker A/P-loop; other site 483219005255 ATP binding site [chemical binding]; other site 483219005256 Q-loop/lid; other site 483219005257 ABC transporter signature motif; other site 483219005258 Walker B; other site 483219005259 D-loop; other site 483219005260 H-loop/switch region; other site 483219005261 TOBE domain; Region: TOBE_2; pfam08402 483219005262 Kelch domain; Region: Kelch; smart00612 483219005263 Kelch motif; Region: Kelch_1; pfam01344 483219005264 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 483219005265 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 483219005266 Kelch motif; Region: Kelch_6; pfam13964 483219005267 Galactose oxidase, central domain; Region: Kelch_3; cl02701 483219005268 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 483219005269 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 483219005270 Kelch motif; Region: Kelch_6; pfam13964 483219005271 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 483219005272 active site 483219005273 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 483219005274 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 483219005275 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 483219005276 active site 483219005277 catalytic residues [active] 483219005278 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538 483219005279 PA/protease or protease-like domain interface [polypeptide binding]; other site 483219005280 Subtilase family; Region: Peptidase_S8; pfam00082 483219005281 catalytic residues [active] 483219005282 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219005283 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219005284 active site 483219005285 ATP binding site [chemical binding]; other site 483219005286 substrate binding site [chemical binding]; other site 483219005287 activation loop (A-loop); other site 483219005288 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 483219005289 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 483219005290 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219005291 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219005292 phosphorylation site [posttranslational modification] 483219005293 dimer interface [polypeptide binding]; other site 483219005294 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219005295 ATP binding site [chemical binding]; other site 483219005296 Mg2+ binding site [ion binding]; other site 483219005297 G-X-G motif; other site 483219005298 Response regulator receiver domain; Region: Response_reg; pfam00072 483219005299 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219005300 active site 483219005301 phosphorylation site [posttranslational modification] 483219005302 intermolecular recognition site; other site 483219005303 dimerization interface [polypeptide binding]; other site 483219005304 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 483219005305 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 483219005306 FMN-binding pocket [chemical binding]; other site 483219005307 flavin binding motif; other site 483219005308 phosphate binding motif [ion binding]; other site 483219005309 beta-alpha-beta structure motif; other site 483219005310 NAD binding pocket [chemical binding]; other site 483219005311 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 483219005312 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 483219005313 catalytic loop [active] 483219005314 iron binding site [ion binding]; other site 483219005315 Hemerythrin-like domain; Region: Hr-like; cd12108 483219005316 Fe binding site [ion binding]; other site 483219005317 Uncharacterized conserved protein [Function unknown]; Region: COG2968 483219005318 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 483219005319 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 483219005320 active site 483219005321 Int/Topo IB signature motif; other site 483219005322 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 483219005323 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 483219005324 putative catalytic site [active] 483219005325 putative metal binding site [ion binding]; other site 483219005326 putative phosphate binding site [ion binding]; other site 483219005327 Lamin Tail Domain; Region: LTD; pfam00932 483219005328 IgA Peptidase M64; Region: Peptidase_M64; pfam09471 483219005329 PEGA domain; Region: PEGA; pfam08308 483219005330 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 483219005331 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 483219005332 putative NAD(P) binding site [chemical binding]; other site 483219005333 active site 483219005334 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 483219005335 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 483219005336 nudix motif; other site 483219005337 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 483219005338 Protein phosphatase 2C; Region: PP2C_2; pfam13672 483219005339 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 483219005340 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 483219005341 catalytic triad [active] 483219005342 conserved cis-peptide bond; other site 483219005343 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219005344 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 483219005345 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219005346 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 483219005347 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219005348 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219005349 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 483219005350 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 483219005351 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 483219005352 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 483219005353 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 483219005354 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 483219005355 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 483219005356 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 483219005357 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 483219005358 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 483219005359 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 483219005360 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 483219005361 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 483219005362 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 483219005363 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 483219005364 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 483219005365 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 483219005366 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 483219005367 DNA binding residues [nucleotide binding] 483219005368 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 483219005369 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 483219005370 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 483219005371 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 483219005372 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 483219005373 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219005374 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219005375 dimerization interface [polypeptide binding]; other site 483219005376 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219005377 dimer interface [polypeptide binding]; other site 483219005378 phosphorylation site [posttranslational modification] 483219005379 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219005380 ATP binding site [chemical binding]; other site 483219005381 Mg2+ binding site [ion binding]; other site 483219005382 G-X-G motif; other site 483219005383 Response regulator receiver domain; Region: Response_reg; pfam00072 483219005384 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219005385 active site 483219005386 phosphorylation site [posttranslational modification] 483219005387 intermolecular recognition site; other site 483219005388 dimerization interface [polypeptide binding]; other site 483219005389 PEGA domain; Region: PEGA; pfam08308 483219005390 Type II/IV secretion system protein; Region: T2SE; pfam00437 483219005391 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 483219005392 Walker A motif; other site 483219005393 ATP binding site [chemical binding]; other site 483219005394 Walker B motif; other site 483219005395 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 483219005396 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 483219005397 non-specific DNA binding site [nucleotide binding]; other site 483219005398 salt bridge; other site 483219005399 sequence-specific DNA binding site [nucleotide binding]; other site 483219005400 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 483219005401 active site 483219005402 oxyanion hole [active] 483219005403 catalytic triad [active] 483219005404 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 483219005405 Beta-lactamase; Region: Beta-lactamase; pfam00144 483219005406 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 483219005407 Protein of unknown function (DUF2381); Region: DUF2381; cl15442 483219005408 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219005409 active site 483219005410 ATP binding site [chemical binding]; other site 483219005411 substrate binding site [chemical binding]; other site 483219005412 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 483219005413 Protein kinase domain; Region: Pkinase; pfam00069 483219005414 active site 483219005415 ATP binding site [chemical binding]; other site 483219005416 substrate binding site [chemical binding]; other site 483219005417 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 483219005418 substrate binding site [chemical binding]; other site 483219005419 activation loop (A-loop); other site 483219005420 activation loop (A-loop); other site 483219005421 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 483219005422 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 483219005423 active site 483219005424 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 483219005425 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 483219005426 putative ligand binding site [chemical binding]; other site 483219005427 putative NAD binding site [chemical binding]; other site 483219005428 catalytic site [active] 483219005429 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 483219005430 Ligand Binding Site [chemical binding]; other site 483219005431 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 483219005432 Ligand Binding Site [chemical binding]; other site 483219005433 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 483219005434 Ligand Binding Site [chemical binding]; other site 483219005435 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 483219005436 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 483219005437 active site 483219005438 metal binding site [ion binding]; metal-binding site 483219005439 Putative zinc-finger; Region: zf-HC2; pfam13490 483219005440 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219005441 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219005442 active site 483219005443 ATP binding site [chemical binding]; other site 483219005444 substrate binding site [chemical binding]; other site 483219005445 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 483219005446 substrate binding site [chemical binding]; other site 483219005447 activation loop (A-loop); other site 483219005448 activation loop (A-loop); other site 483219005449 Tetratricopeptide repeat; Region: TPR_12; pfam13424 483219005450 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219005451 binding surface 483219005452 TPR motif; other site 483219005453 Tetratricopeptide repeat; Region: TPR_12; pfam13424 483219005454 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219005455 binding surface 483219005456 TPR motif; other site 483219005457 Tetratricopeptide repeat; Region: TPR_12; pfam13424 483219005458 Tetratricopeptide repeat; Region: TPR_12; pfam13424 483219005459 RNA polymerase sigma-70 factor, Myxococcales family 1; Region: Sig-70_gmx1; TIGR03001 483219005460 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 483219005461 DNA binding residues [nucleotide binding] 483219005462 alanine racemase; Reviewed; Region: alr; PRK00053 483219005463 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 483219005464 active site 483219005465 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 483219005466 dimer interface [polypeptide binding]; other site 483219005467 substrate binding site [chemical binding]; other site 483219005468 catalytic residues [active] 483219005469 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 483219005470 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 483219005471 putative acyl-acceptor binding pocket; other site 483219005472 Peptidase family M1; Region: Peptidase_M1; pfam01433 483219005473 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 483219005474 Zn binding site [ion binding]; other site 483219005475 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 483219005476 enoyl-CoA hydratase; Provisional; Region: PRK06688 483219005477 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 483219005478 substrate binding site [chemical binding]; other site 483219005479 oxyanion hole (OAH) forming residues; other site 483219005480 trimer interface [polypeptide binding]; other site 483219005481 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK00934 483219005482 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 483219005483 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 483219005484 active site 483219005485 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 483219005486 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 483219005487 Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951 483219005488 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 483219005489 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 483219005490 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 483219005491 catalytic site [active] 483219005492 putative active site [active] 483219005493 putative substrate binding site [chemical binding]; other site 483219005494 dimer interface [polypeptide binding]; other site 483219005495 Response regulator receiver domain; Region: Response_reg; pfam00072 483219005496 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219005497 active site 483219005498 phosphorylation site [posttranslational modification] 483219005499 intermolecular recognition site; other site 483219005500 dimerization interface [polypeptide binding]; other site 483219005501 circadian clock protein KaiC; Reviewed; Region: PRK09302 483219005502 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 483219005503 Walker A motif; other site 483219005504 ATP binding site [chemical binding]; other site 483219005505 Walker B motif; other site 483219005506 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 483219005507 Walker A motif; other site 483219005508 ATP binding site [chemical binding]; other site 483219005509 Walker B motif; other site 483219005510 malonyl-CoA synthase; Validated; Region: PRK07514 483219005511 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 483219005512 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 483219005513 acyl-activating enzyme (AAE) consensus motif; other site 483219005514 acyl-activating enzyme (AAE) consensus motif; other site 483219005515 AMP binding site [chemical binding]; other site 483219005516 active site 483219005517 CoA binding site [chemical binding]; other site 483219005518 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 483219005519 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 483219005520 HlyD family secretion protein; Region: HlyD_3; pfam13437 483219005521 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 483219005522 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 483219005523 Walker A/P-loop; other site 483219005524 ATP binding site [chemical binding]; other site 483219005525 Q-loop/lid; other site 483219005526 ABC transporter signature motif; other site 483219005527 Walker B; other site 483219005528 D-loop; other site 483219005529 H-loop/switch region; other site 483219005530 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 483219005531 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 483219005532 Walker A/P-loop; other site 483219005533 ATP binding site [chemical binding]; other site 483219005534 Q-loop/lid; other site 483219005535 ABC transporter signature motif; other site 483219005536 Walker B; other site 483219005537 D-loop; other site 483219005538 H-loop/switch region; other site 483219005539 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 483219005540 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219005541 active site 483219005542 phosphorylation site [posttranslational modification] 483219005543 intermolecular recognition site; other site 483219005544 dimerization interface [polypeptide binding]; other site 483219005545 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219005546 Walker A motif; other site 483219005547 ATP binding site [chemical binding]; other site 483219005548 Walker B motif; other site 483219005549 arginine finger; other site 483219005550 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 483219005551 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219005552 PAS domain; Region: PAS; smart00091 483219005553 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219005554 ATP binding site [chemical binding]; other site 483219005555 Mg2+ binding site [ion binding]; other site 483219005556 G-X-G motif; other site 483219005557 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 483219005558 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 483219005559 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 483219005560 Competence-damaged protein; Region: CinA; pfam02464 483219005561 conserved hypothetical protein; Region: TIGR02270 483219005562 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 483219005563 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 483219005564 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 483219005565 Family description; Region: VCBS; pfam13517 483219005566 Family description; Region: VCBS; pfam13517 483219005567 Family description; Region: VCBS; pfam13517 483219005568 Family description; Region: VCBS; pfam13517 483219005569 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 483219005570 GH3 auxin-responsive promoter; Region: GH3; pfam03321 483219005571 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 483219005572 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 483219005573 [2Fe-2S] cluster binding site [ion binding]; other site 483219005574 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 483219005575 hydrophobic ligand binding site; other site 483219005576 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 483219005577 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219005578 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219005579 dimer interface [polypeptide binding]; other site 483219005580 phosphorylation site [posttranslational modification] 483219005581 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219005582 ATP binding site [chemical binding]; other site 483219005583 Mg2+ binding site [ion binding]; other site 483219005584 G-X-G motif; other site 483219005585 2TM domain; Region: 2TM; pfam13239 483219005586 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 483219005587 trimer interface [polypeptide binding]; other site 483219005588 putative metal binding site [ion binding]; other site 483219005589 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 483219005590 putative trimer interface [polypeptide binding]; other site 483219005591 putative CoA binding site [chemical binding]; other site 483219005592 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 483219005593 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 483219005594 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 483219005595 conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806 483219005596 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 483219005597 parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805 483219005598 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 483219005599 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 483219005600 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 483219005601 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 483219005602 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 483219005603 SCP_PR-1_like: SCP-like extracellular protein domain, PR-1 like subfamily. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal...; Region: SCP_PR-1_like; cd05381 483219005604 SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133 483219005605 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 483219005606 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 483219005607 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 483219005608 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 483219005609 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 483219005610 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 483219005611 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 483219005612 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 483219005613 FAD binding pocket [chemical binding]; other site 483219005614 FAD binding motif [chemical binding]; other site 483219005615 phosphate binding motif [ion binding]; other site 483219005616 beta-alpha-beta structure motif; other site 483219005617 NAD binding pocket [chemical binding]; other site 483219005618 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 483219005619 Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin; Region: M3A_TOP; cd06455 483219005620 active site 483219005621 Zn binding site [ion binding]; other site 483219005622 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 483219005623 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 483219005624 putative metal binding site [ion binding]; other site 483219005625 putative homodimer interface [polypeptide binding]; other site 483219005626 putative homotetramer interface [polypeptide binding]; other site 483219005627 putative homodimer-homodimer interface [polypeptide binding]; other site 483219005628 putative allosteric switch controlling residues; other site 483219005629 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 483219005630 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 483219005631 substrate binding site [chemical binding]; other site 483219005632 catalytic Zn binding site [ion binding]; other site 483219005633 NAD binding site [chemical binding]; other site 483219005634 structural Zn binding site [ion binding]; other site 483219005635 dimer interface [polypeptide binding]; other site 483219005636 S-formylglutathione hydrolase; Region: PLN02442 483219005637 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 483219005638 5' nucleotidase family; Region: 5_nucleotid; pfam05761 483219005639 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 483219005640 catalytic residues [active] 483219005641 dimer interface [polypeptide binding]; other site 483219005642 Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876 483219005643 putative lipid binding site [chemical binding]; other site 483219005644 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 483219005645 methionine aminopeptidase; Provisional; Region: PRK12318 483219005646 SEC-C motif; Region: SEC-C; pfam02810 483219005647 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 483219005648 active site 483219005649 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219005650 S-adenosylmethionine binding site [chemical binding]; other site 483219005651 Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135 483219005652 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 483219005653 putative catalytic site [active] 483219005654 putative phosphate binding site [ion binding]; other site 483219005655 putative metal binding site [ion binding]; other site 483219005656 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 483219005657 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 483219005658 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 483219005659 DNA-binding site [nucleotide binding]; DNA binding site 483219005660 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 483219005661 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483219005662 homodimer interface [polypeptide binding]; other site 483219005663 catalytic residue [active] 483219005664 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 483219005665 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 483219005666 active site 483219005667 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219005668 S-adenosylmethionine binding site [chemical binding]; other site 483219005669 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 483219005670 metal ion-dependent adhesion site (MIDAS); other site 483219005671 Protein of unknown function (DUF962); Region: DUF962; pfam06127 483219005672 Methyltransferase domain; Region: Methyltransf_11; pfam08241 483219005673 Domain of unknown function (DUF4265); Region: DUF4265; pfam14085 483219005674 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 483219005675 active site 483219005676 carbon starvation protein A; Provisional; Region: PRK15015 483219005677 Carbon starvation protein CstA; Region: CstA; pfam02554 483219005678 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 483219005679 Protein of unknown function (DUF466); Region: DUF466; pfam04328 483219005680 hypothetical protein; Provisional; Region: PRK12378 483219005681 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 483219005682 sugar binding site [chemical binding]; other site 483219005683 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 483219005684 sugar binding site [chemical binding]; other site 483219005685 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 483219005686 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 483219005687 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 483219005688 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 483219005689 methionine sulfoxide reductase A; Provisional; Region: PRK00058 483219005690 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 483219005691 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 483219005692 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 483219005693 photoactive yellow protein; Region: photo_yellow; TIGR02373 483219005694 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219005695 dimer interface [polypeptide binding]; other site 483219005696 phosphorylation site [posttranslational modification] 483219005697 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219005698 ATP binding site [chemical binding]; other site 483219005699 Mg2+ binding site [ion binding]; other site 483219005700 G-X-G motif; other site 483219005701 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 483219005702 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 483219005703 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483219005704 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 483219005705 NmrA-like family; Region: NmrA; pfam05368 483219005706 NADP binding site [chemical binding]; other site 483219005707 active site 483219005708 regulatory binding site [polypeptide binding]; other site 483219005709 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 483219005710 Uncharacterized conserved protein (DUF2203); Region: DUF2203; pfam09969 483219005711 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cl00653 483219005712 Active_site [active] 483219005713 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 483219005714 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 483219005715 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 483219005716 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 483219005717 BNR repeat-like domain; Region: BNR_2; pfam13088 483219005718 Asp-box motif; other site 483219005719 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 483219005720 active site 483219005721 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 483219005722 catalytic tetrad [active] 483219005723 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 483219005724 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 483219005725 ligand binding site [chemical binding]; other site 483219005726 flexible hinge region; other site 483219005727 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 483219005728 Bacterial virulence factor lipase N-terminal; Region: Lipase_bact_N; pfam12262 483219005729 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 483219005730 ligand binding site [chemical binding]; other site 483219005731 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 483219005732 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 483219005733 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 483219005734 putative dimer interface [polypeptide binding]; other site 483219005735 N-terminal domain interface [polypeptide binding]; other site 483219005736 putative substrate binding pocket (H-site) [chemical binding]; other site 483219005737 MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804 483219005738 active site 483219005739 Response regulator receiver domain; Region: Response_reg; pfam00072 483219005740 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219005741 active site 483219005742 phosphorylation site [posttranslational modification] 483219005743 intermolecular recognition site; other site 483219005744 dimerization interface [polypeptide binding]; other site 483219005745 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 483219005746 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 483219005747 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 483219005748 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 483219005749 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 483219005750 beta subunit interaction interface [polypeptide binding]; other site 483219005751 Walker A motif; other site 483219005752 ATP binding site [chemical binding]; other site 483219005753 Walker B motif; other site 483219005754 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 483219005755 PAS fold; Region: PAS_4; pfam08448 483219005756 PAS domain S-box; Region: sensory_box; TIGR00229 483219005757 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219005758 putative active site [active] 483219005759 heme pocket [chemical binding]; other site 483219005760 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219005761 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219005762 dimer interface [polypeptide binding]; other site 483219005763 phosphorylation site [posttranslational modification] 483219005764 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219005765 ATP binding site [chemical binding]; other site 483219005766 G-X-G motif; other site 483219005767 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 483219005768 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 483219005769 chaperone protein DnaK; Region: prok_dnaK; TIGR02350 483219005770 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 483219005771 nucleotide binding site [chemical binding]; other site 483219005772 putative NEF/HSP70 interaction site [polypeptide binding]; other site 483219005773 SBD interface [polypeptide binding]; other site 483219005774 Response regulator receiver domain; Region: Response_reg; pfam00072 483219005775 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219005776 active site 483219005777 phosphorylation site [posttranslational modification] 483219005778 intermolecular recognition site; other site 483219005779 dimerization interface [polypeptide binding]; other site 483219005780 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 483219005781 PilZ domain; Region: PilZ; cl01260 483219005782 Beta propeller domain; Region: Beta_propel; pfam09826 483219005783 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 483219005784 multidrug efflux protein; Reviewed; Region: PRK01766 483219005785 cation binding site [ion binding]; other site 483219005786 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 483219005787 Putative esterase; Region: Esterase; pfam00756 483219005788 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 483219005789 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 483219005790 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 483219005791 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752 483219005792 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004 483219005793 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cd09689 483219005794 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 483219005795 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 483219005796 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 483219005797 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 483219005798 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 483219005799 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219005800 Walker A motif; other site 483219005801 ATP binding site [chemical binding]; other site 483219005802 Walker B motif; other site 483219005803 arginine finger; other site 483219005804 Response regulator receiver domain; Region: Response_reg; pfam00072 483219005805 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219005806 active site 483219005807 phosphorylation site [posttranslational modification] 483219005808 intermolecular recognition site; other site 483219005809 dimerization interface [polypeptide binding]; other site 483219005810 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219005811 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219005812 dimer interface [polypeptide binding]; other site 483219005813 phosphorylation site [posttranslational modification] 483219005814 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219005815 ATP binding site [chemical binding]; other site 483219005816 Mg2+ binding site [ion binding]; other site 483219005817 G-X-G motif; other site 483219005818 PAS domain; Region: PAS_9; pfam13426 483219005819 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219005820 putative active site [active] 483219005821 heme pocket [chemical binding]; other site 483219005822 PAS domain; Region: PAS_9; pfam13426 483219005823 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219005824 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219005825 dimer interface [polypeptide binding]; other site 483219005826 phosphorylation site [posttranslational modification] 483219005827 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219005828 ATP binding site [chemical binding]; other site 483219005829 Mg2+ binding site [ion binding]; other site 483219005830 G-X-G motif; other site 483219005831 Response regulator receiver domain; Region: Response_reg; pfam00072 483219005832 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219005833 active site 483219005834 phosphorylation site [posttranslational modification] 483219005835 intermolecular recognition site; other site 483219005836 dimerization interface [polypeptide binding]; other site 483219005837 Myxococcales-restricted protein, TIGR02265 family; Region: Mxa_TIGR02265 483219005838 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 483219005839 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 483219005840 sequence-specific DNA binding site [nucleotide binding]; other site 483219005841 salt bridge; other site 483219005842 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 483219005843 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 483219005844 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 483219005845 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 483219005846 ligand binding site [chemical binding]; other site 483219005847 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 483219005848 Cna protein B-type domain; Region: Cna_B_2; pfam13715 483219005849 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 483219005850 Response regulator receiver domain; Region: Response_reg; pfam00072 483219005851 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219005852 active site 483219005853 phosphorylation site [posttranslational modification] 483219005854 intermolecular recognition site; other site 483219005855 dimerization interface [polypeptide binding]; other site 483219005856 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 483219005857 GAF domain; Region: GAF; pfam01590 483219005858 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 483219005859 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219005860 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219005861 dimer interface [polypeptide binding]; other site 483219005862 phosphorylation site [posttranslational modification] 483219005863 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219005864 ATP binding site [chemical binding]; other site 483219005865 Mg2+ binding site [ion binding]; other site 483219005866 G-X-G motif; other site 483219005867 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219005868 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219005869 dimer interface [polypeptide binding]; other site 483219005870 phosphorylation site [posttranslational modification] 483219005871 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219005872 ATP binding site [chemical binding]; other site 483219005873 Mg2+ binding site [ion binding]; other site 483219005874 G-X-G motif; other site 483219005875 GLTT repeat (6 copies); Region: GLTT; pfam01744 483219005876 Protein of unknown function (Gmx_para_CXXCG); Region: Gmx_para_CXXCG; pfam09535 483219005877 enoyl-CoA hydratase; Provisional; Region: PRK08260 483219005878 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 483219005879 substrate binding site [chemical binding]; other site 483219005880 oxyanion hole (OAH) forming residues; other site 483219005881 trimer interface [polypeptide binding]; other site 483219005882 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 483219005883 short chain dehydrogenase; Provisional; Region: PRK08278 483219005884 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 483219005885 NAD(P) binding site [chemical binding]; other site 483219005886 active site 483219005887 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 483219005888 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 483219005889 acyl-activating enzyme (AAE) consensus motif; other site 483219005890 putative AMP binding site [chemical binding]; other site 483219005891 putative active site [active] 483219005892 putative CoA binding site [chemical binding]; other site 483219005893 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 483219005894 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 483219005895 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 483219005896 active site 483219005897 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 483219005898 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 483219005899 active site 483219005900 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 483219005901 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 483219005902 dimer interface [polypeptide binding]; other site 483219005903 active site 483219005904 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 483219005905 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 483219005906 substrate binding site [chemical binding]; other site 483219005907 oxyanion hole (OAH) forming residues; other site 483219005908 trimer interface [polypeptide binding]; other site 483219005909 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 483219005910 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 483219005911 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 483219005912 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 483219005913 NAD(P) binding site [chemical binding]; other site 483219005914 catalytic residues [active] 483219005915 Tubby C 2; Region: Tub_2; cl02043 483219005916 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 483219005917 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219005918 active site 483219005919 phosphorylation site [posttranslational modification] 483219005920 intermolecular recognition site; other site 483219005921 dimerization interface [polypeptide binding]; other site 483219005922 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 483219005923 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 483219005924 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219005925 ATP binding site [chemical binding]; other site 483219005926 Mg2+ binding site [ion binding]; other site 483219005927 G-X-G motif; other site 483219005928 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 483219005929 Predicted membrane protein [Function unknown]; Region: COG2259 483219005930 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 483219005931 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 483219005932 putative active site [active] 483219005933 putative metal binding site [ion binding]; other site 483219005934 PAS fold; Region: PAS_4; pfam08448 483219005935 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219005936 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219005937 dimer interface [polypeptide binding]; other site 483219005938 phosphorylation site [posttranslational modification] 483219005939 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219005940 ATP binding site [chemical binding]; other site 483219005941 Mg2+ binding site [ion binding]; other site 483219005942 G-X-G motif; other site 483219005943 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 483219005944 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219005945 active site 483219005946 phosphorylation site [posttranslational modification] 483219005947 intermolecular recognition site; other site 483219005948 dimerization interface [polypeptide binding]; other site 483219005949 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 483219005950 metal binding site 2 [ion binding]; metal-binding site 483219005951 putative DNA binding helix; other site 483219005952 metal binding site 1 [ion binding]; metal-binding site 483219005953 dimer interface [polypeptide binding]; other site 483219005954 structural Zn2+ binding site [ion binding]; other site 483219005955 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219005956 active site 483219005957 phosphorylation site [posttranslational modification] 483219005958 intermolecular recognition site; other site 483219005959 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219005960 PAS fold; Region: PAS_3; pfam08447 483219005961 putative active site [active] 483219005962 heme pocket [chemical binding]; other site 483219005963 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219005964 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219005965 dimer interface [polypeptide binding]; other site 483219005966 phosphorylation site [posttranslational modification] 483219005967 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219005968 ATP binding site [chemical binding]; other site 483219005969 Mg2+ binding site [ion binding]; other site 483219005970 G-X-G motif; other site 483219005971 Response regulator receiver domain; Region: Response_reg; pfam00072 483219005972 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219005973 active site 483219005974 phosphorylation site [posttranslational modification] 483219005975 intermolecular recognition site; other site 483219005976 dimerization interface [polypeptide binding]; other site 483219005977 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 483219005978 putative binding surface; other site 483219005979 active site 483219005980 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219005981 ATP binding site [chemical binding]; other site 483219005982 Mg2+ binding site [ion binding]; other site 483219005983 G-X-G motif; other site 483219005984 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 483219005985 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 483219005986 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 483219005987 putative CheW interface [polypeptide binding]; other site 483219005988 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 483219005989 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 483219005990 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 483219005991 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 483219005992 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219005993 active site 483219005994 phosphorylation site [posttranslational modification] 483219005995 intermolecular recognition site; other site 483219005996 CheB methylesterase; Region: CheB_methylest; pfam01339 483219005997 Fatty acid desaturase; Region: FA_desaturase; pfam00487 483219005998 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cd01060 483219005999 putative di-iron ligands [ion binding]; other site 483219006000 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 483219006001 PilZ domain; Region: PilZ; cl01260 483219006002 Response regulator receiver domain; Region: Response_reg; pfam00072 483219006003 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219006004 active site 483219006005 phosphorylation site [posttranslational modification] 483219006006 intermolecular recognition site; other site 483219006007 dimerization interface [polypeptide binding]; other site 483219006008 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 483219006009 PAS fold; Region: PAS_4; pfam08448 483219006010 PAS domain; Region: PAS; smart00091 483219006011 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 483219006012 putative active site [active] 483219006013 heme pocket [chemical binding]; other site 483219006014 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219006015 dimer interface [polypeptide binding]; other site 483219006016 phosphorylation site [posttranslational modification] 483219006017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219006018 ATP binding site [chemical binding]; other site 483219006019 Mg2+ binding site [ion binding]; other site 483219006020 G-X-G motif; other site 483219006021 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219006022 PAS fold; Region: PAS_4; pfam08448 483219006023 putative active site [active] 483219006024 heme pocket [chemical binding]; other site 483219006025 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 483219006026 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 483219006027 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219006028 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219006029 dimer interface [polypeptide binding]; other site 483219006030 phosphorylation site [posttranslational modification] 483219006031 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219006032 ATP binding site [chemical binding]; other site 483219006033 Mg2+ binding site [ion binding]; other site 483219006034 G-X-G motif; other site 483219006035 potential frameshift: common BLAST hit: gi|108760148|ref|YP_635067.1| protein-glutamate methylesterase 483219006036 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 483219006037 putative binding surface; other site 483219006038 active site 483219006039 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 483219006040 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219006041 ATP binding site [chemical binding]; other site 483219006042 Mg2+ binding site [ion binding]; other site 483219006043 G-X-G motif; other site 483219006044 Response regulator receiver domain; Region: Response_reg; pfam00072 483219006045 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219006046 active site 483219006047 phosphorylation site [posttranslational modification] 483219006048 intermolecular recognition site; other site 483219006049 dimerization interface [polypeptide binding]; other site 483219006050 CHASE3 domain; Region: CHASE3; pfam05227 483219006051 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219006052 dimerization interface [polypeptide binding]; other site 483219006053 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 483219006054 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 483219006055 dimer interface [polypeptide binding]; other site 483219006056 putative CheW interface [polypeptide binding]; other site 483219006057 CheW-like domain; Region: CheW; pfam01584 483219006058 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 483219006059 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 483219006060 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 483219006061 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 483219006062 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 483219006063 Beta-ketoacyl synthase, C-terminal domain; Region: Ketoacyl-synt_C; pfam02801 483219006064 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 483219006065 conserved hypothetical protein; Region: TIGR02270 483219006066 Protein of unknown function (DUF2379); Region: DUF2379; cl15283 483219006067 Protein of unknown function (DUF2379); Region: DUF2379; pfam09543 483219006068 Protein of unknown function (DUF2379); Region: DUF2379; cl15283 483219006069 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 483219006070 Protein of unknown function (DUF2381); Region: DUF2381; cl15442 483219006071 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219006072 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219006073 active site 483219006074 ATP binding site [chemical binding]; other site 483219006075 substrate binding site [chemical binding]; other site 483219006076 activation loop (A-loop); other site 483219006077 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 483219006078 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 483219006079 non-specific DNA binding site [nucleotide binding]; other site 483219006080 salt bridge; other site 483219006081 sequence-specific DNA binding site [nucleotide binding]; other site 483219006082 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219006083 active site 483219006084 ATP binding site [chemical binding]; other site 483219006085 substrate binding site [chemical binding]; other site 483219006086 activation loop (A-loop); other site 483219006087 CHASE domain; Region: CHASE; pfam03924 483219006088 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219006089 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219006090 dimer interface [polypeptide binding]; other site 483219006091 phosphorylation site [posttranslational modification] 483219006092 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219006093 ATP binding site [chemical binding]; other site 483219006094 Mg2+ binding site [ion binding]; other site 483219006095 G-X-G motif; other site 483219006096 phytoene desaturase; Region: crtI_fam; TIGR02734 483219006097 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 483219006098 RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678 483219006099 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 483219006100 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 483219006101 dimer interface [polypeptide binding]; other site 483219006102 putative CheW interface [polypeptide binding]; other site 483219006103 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 483219006104 Ligand Binding Site [chemical binding]; other site 483219006105 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 483219006106 Ligand Binding Site [chemical binding]; other site 483219006107 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 483219006108 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219006109 Walker A/P-loop; other site 483219006110 ATP binding site [chemical binding]; other site 483219006111 Q-loop/lid; other site 483219006112 ABC transporter signature motif; other site 483219006113 Walker B; other site 483219006114 D-loop; other site 483219006115 H-loop/switch region; other site 483219006116 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 483219006117 putative active site [active] 483219006118 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 483219006119 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 483219006120 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 483219006121 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 483219006122 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 483219006123 catalytic residues [active] 483219006124 CotH protein; Region: CotH; pfam08757 483219006125 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 483219006126 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 483219006127 putative active site [active] 483219006128 Response regulator receiver domain; Region: Response_reg; pfam00072 483219006129 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219006130 active site 483219006131 phosphorylation site [posttranslational modification] 483219006132 intermolecular recognition site; other site 483219006133 dimerization interface [polypeptide binding]; other site 483219006134 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 483219006135 core domain interface [polypeptide binding]; other site 483219006136 delta subunit interface [polypeptide binding]; other site 483219006137 epsilon subunit interface [polypeptide binding]; other site 483219006138 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 483219006139 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 483219006140 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 483219006141 alpha subunit interaction interface [polypeptide binding]; other site 483219006142 Walker A motif; other site 483219006143 ATP binding site [chemical binding]; other site 483219006144 Walker B motif; other site 483219006145 inhibitor binding site; inhibition site 483219006146 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 483219006147 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 483219006148 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 483219006149 gamma subunit interface [polypeptide binding]; other site 483219006150 epsilon subunit interface [polypeptide binding]; other site 483219006151 LBP interface [polypeptide binding]; other site 483219006152 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 483219006153 apolar tunnel; other site 483219006154 heme binding site [chemical binding]; other site 483219006155 dimerization interface [polypeptide binding]; other site 483219006156 hypothetical protein; Provisional; Region: PRK05713 483219006157 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 483219006158 catalytic loop [active] 483219006159 iron binding site [ion binding]; other site 483219006160 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194 483219006161 FAD binding pocket [chemical binding]; other site 483219006162 FAD binding motif [chemical binding]; other site 483219006163 phosphate binding motif [ion binding]; other site 483219006164 beta-alpha-beta structure motif; other site 483219006165 NAD binding pocket [chemical binding]; other site 483219006166 Predicted transcriptional regulator [Transcription]; Region: COG1959 483219006167 Transcriptional regulator; Region: Rrf2; cl17282 483219006168 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 483219006169 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 483219006170 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 483219006171 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 483219006172 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 483219006173 Integrase core domain; Region: rve; pfam00665 483219006174 Integrase core domain; Region: rve; pfam00665 483219006175 DDE superfamily endonuclease; Region: DDE_5; cl17874 483219006176 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 483219006177 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 483219006178 N-terminal plug; other site 483219006179 ligand-binding site [chemical binding]; other site 483219006180 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 483219006181 classical (c) SDRs; Region: SDR_c; cd05233 483219006182 NAD(P) binding site [chemical binding]; other site 483219006183 active site 483219006184 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 483219006185 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 483219006186 active site 483219006187 dimer interface [polypeptide binding]; other site 483219006188 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 483219006189 dimer interface [polypeptide binding]; other site 483219006190 active site 483219006191 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 483219006192 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 483219006193 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 483219006194 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 483219006195 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 483219006196 Peptidase family M23; Region: Peptidase_M23; pfam01551 483219006197 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 483219006198 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 483219006199 Dynamin family; Region: Dynamin_N; pfam00350 483219006200 G1 box; other site 483219006201 G1 box; other site 483219006202 GTP/Mg2+ binding site [chemical binding]; other site 483219006203 GTP/Mg2+ binding site [chemical binding]; other site 483219006204 G2 box; other site 483219006205 Switch I region; other site 483219006206 G3 box; other site 483219006207 Switch II region; other site 483219006208 G4 box; other site 483219006209 G5 box; other site 483219006210 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 483219006211 Amidinotransferase; Region: Amidinotransf; cl12043 483219006212 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 483219006213 Lipase maturation factor; Region: LMF1; pfam06762 483219006214 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 483219006215 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 483219006216 ligand binding site [chemical binding]; other site 483219006217 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 483219006218 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 483219006219 catalytic residues [active] 483219006220 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 483219006221 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 483219006222 active site 483219006223 metal binding site [ion binding]; metal-binding site 483219006224 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 483219006225 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 483219006226 DNA binding residues [nucleotide binding] 483219006227 dimerization interface [polypeptide binding]; other site 483219006228 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 483219006229 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 483219006230 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 483219006231 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 483219006232 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 483219006233 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 483219006234 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219006235 S-adenosylmethionine binding site [chemical binding]; other site 483219006236 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 483219006237 NAD(P) binding site [chemical binding]; other site 483219006238 active site 483219006239 Dihydroneopterin aldolase; Region: FolB; pfam02152 483219006240 active site 483219006241 Cupin domain; Region: Cupin_2; cl17218 483219006242 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 483219006243 classical (c) SDRs; Region: SDR_c; cd05233 483219006244 NAD(P) binding site [chemical binding]; other site 483219006245 active site 483219006246 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 483219006247 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 483219006248 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 483219006249 CoA binding site [chemical binding]; other site 483219006250 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 483219006251 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 483219006252 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 483219006253 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E); Region: PHA_synth_III_E; cl09914 483219006254 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 483219006255 putative active site [active] 483219006256 malonic semialdehyde reductase; Provisional; Region: PRK10538 483219006257 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 483219006258 putative NAD(P) binding site [chemical binding]; other site 483219006259 homodimer interface [polypeptide binding]; other site 483219006260 homotetramer interface [polypeptide binding]; other site 483219006261 active site 483219006262 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 483219006263 active site 483219006264 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 483219006265 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 483219006266 Right handed beta helix region; Region: Beta_helix; pfam13229 483219006267 GAF domain; Region: GAF; cl17456 483219006268 PAS fold; Region: PAS_4; pfam08448 483219006269 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219006270 putative active site [active] 483219006271 heme pocket [chemical binding]; other site 483219006272 PAS domain S-box; Region: sensory_box; TIGR00229 483219006273 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219006274 putative active site [active] 483219006275 heme pocket [chemical binding]; other site 483219006276 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219006277 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219006278 dimer interface [polypeptide binding]; other site 483219006279 phosphorylation site [posttranslational modification] 483219006280 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 483219006281 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219006282 putative active site [active] 483219006283 heme pocket [chemical binding]; other site 483219006284 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219006285 dimer interface [polypeptide binding]; other site 483219006286 phosphorylation site [posttranslational modification] 483219006287 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219006288 ATP binding site [chemical binding]; other site 483219006289 Mg2+ binding site [ion binding]; other site 483219006290 G-X-G motif; other site 483219006291 methionine sulfoxide reductase B; Provisional; Region: PRK00222 483219006292 bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550 483219006293 methionine sulfoxide reductase A; Provisional; Region: PRK14054 483219006294 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 483219006295 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 483219006296 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 483219006297 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 483219006298 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 483219006299 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 483219006300 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 483219006301 motif II; other site 483219006302 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 483219006303 TM2 domain; Region: TM2; cl00984 483219006304 MASE1; Region: MASE1; pfam05231 483219006305 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219006306 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 483219006307 putative active site [active] 483219006308 heme pocket [chemical binding]; other site 483219006309 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 483219006310 phosphorylation site [posttranslational modification] 483219006311 dimer interface [polypeptide binding]; other site 483219006312 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219006313 ATP binding site [chemical binding]; other site 483219006314 Mg2+ binding site [ion binding]; other site 483219006315 G-X-G motif; other site 483219006316 Response regulator receiver domain; Region: Response_reg; pfam00072 483219006317 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219006318 active site 483219006319 phosphorylation site [posttranslational modification] 483219006320 intermolecular recognition site; other site 483219006321 dimerization interface [polypeptide binding]; other site 483219006322 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 483219006323 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 483219006324 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 483219006325 NAD synthetase; Provisional; Region: PRK13981 483219006326 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 483219006327 multimer interface [polypeptide binding]; other site 483219006328 active site 483219006329 catalytic triad [active] 483219006330 protein interface 1 [polypeptide binding]; other site 483219006331 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 483219006332 homodimer interface [polypeptide binding]; other site 483219006333 NAD binding pocket [chemical binding]; other site 483219006334 ATP binding pocket [chemical binding]; other site 483219006335 Mg binding site [ion binding]; other site 483219006336 active-site loop [active] 483219006337 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 483219006338 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 483219006339 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 483219006340 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 483219006341 catalytic residues [active] 483219006342 Response regulator receiver domain; Region: Response_reg; pfam00072 483219006343 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219006344 active site 483219006345 phosphorylation site [posttranslational modification] 483219006346 intermolecular recognition site; other site 483219006347 dimerization interface [polypeptide binding]; other site 483219006348 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219006349 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219006350 dimer interface [polypeptide binding]; other site 483219006351 phosphorylation site [posttranslational modification] 483219006352 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219006353 ATP binding site [chemical binding]; other site 483219006354 Mg2+ binding site [ion binding]; other site 483219006355 G-X-G motif; other site 483219006356 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 483219006357 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 483219006358 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 483219006359 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 483219006360 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 483219006361 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 483219006362 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 483219006363 ligand binding site [chemical binding]; other site 483219006364 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 483219006365 putative catalytic site [active] 483219006366 putative metal binding site [ion binding]; other site 483219006367 putative phosphate binding site [ion binding]; other site 483219006368 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 483219006369 EcsC protein family; Region: EcsC; pfam12787 483219006370 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 483219006371 tetramerization interface [polypeptide binding]; other site 483219006372 active site 483219006373 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 483219006374 Late embryogenesis abundant protein; Region: LEA_2; cl12118 483219006375 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 483219006376 TAP-like protein; Region: Abhydrolase_4; pfam08386 483219006377 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 483219006378 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 483219006379 ATP-binding cassette domain of the Na+ transporter; Region: ABC_NatA_sodium_exporter; cd03266 483219006380 Walker A/P-loop; other site 483219006381 ATP binding site [chemical binding]; other site 483219006382 Q-loop/lid; other site 483219006383 ABC transporter signature motif; other site 483219006384 Walker B; other site 483219006385 D-loop; other site 483219006386 H-loop/switch region; other site 483219006387 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 483219006388 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 483219006389 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 483219006390 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 483219006391 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 483219006392 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 483219006393 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 483219006394 Zn binding site [ion binding]; other site 483219006395 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 483219006396 16S rRNA processing protein RimM; Region: 16S_RimM; TIGR02273 483219006397 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 483219006398 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 483219006399 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 483219006400 active site 483219006401 metal binding site [ion binding]; metal-binding site 483219006402 Cytochrome c [Energy production and conversion]; Region: COG3258 483219006403 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 483219006404 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 483219006405 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 483219006406 Biofilm formation and stress response factor; Region: BsmA; pfam10014 483219006407 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 483219006408 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 483219006409 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 483219006410 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 483219006411 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219006412 S-adenosylmethionine binding site [chemical binding]; other site 483219006413 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 483219006414 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219006415 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 483219006416 active site 483219006417 Walker A/P-loop; other site 483219006418 ATP binding site [chemical binding]; other site 483219006419 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 483219006420 active site 483219006421 metal binding site [ion binding]; metal-binding site 483219006422 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 483219006423 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 483219006424 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 483219006425 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 483219006426 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 483219006427 RNA binding surface [nucleotide binding]; other site 483219006428 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_3; cd13148 483219006429 putative efflux protein, MATE family; Region: matE; TIGR00797 483219006430 short chain dehydrogenase; Validated; Region: PRK08264 483219006431 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 483219006432 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 483219006433 catalytic Zn binding site [ion binding]; other site 483219006434 NADP binding site [chemical binding]; other site 483219006435 tetramer interface [polypeptide binding]; other site 483219006436 phosphoenolpyruvate synthase; Validated; Region: PRK06464 483219006437 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 483219006438 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 483219006439 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 483219006440 Uncharacterized conserved protein [Function unknown]; Region: COG4748 483219006441 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 483219006442 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 483219006443 non-specific DNA binding site [nucleotide binding]; other site 483219006444 salt bridge; other site 483219006445 sequence-specific DNA binding site [nucleotide binding]; other site 483219006446 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 483219006447 active site 483219006448 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 483219006449 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 483219006450 Domain of unknown function (DUF378); Region: DUF378; pfam04070 483219006451 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 483219006452 C-terminal domain interface [polypeptide binding]; other site 483219006453 GSH binding site (G-site) [chemical binding]; other site 483219006454 dimer interface [polypeptide binding]; other site 483219006455 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 483219006456 N-terminal domain interface [polypeptide binding]; other site 483219006457 rod shape-determining protein MreB; Provisional; Region: PRK13927 483219006458 MreB and similar proteins; Region: MreB_like; cd10225 483219006459 nucleotide binding site [chemical binding]; other site 483219006460 Mg binding site [ion binding]; other site 483219006461 putative protofilament interaction site [polypeptide binding]; other site 483219006462 RodZ interaction site [polypeptide binding]; other site 483219006463 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 483219006464 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 483219006465 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 483219006466 TrkA-C domain; Region: TrkA_C; pfam02080 483219006467 TrkA-C domain; Region: TrkA_C; pfam02080 483219006468 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 483219006469 Ligand binding site; other site 483219006470 Putative Catalytic site; other site 483219006471 DXD motif; other site 483219006472 tyrosine decarboxylase; Region: PLN02880 483219006473 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 483219006474 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 483219006475 catalytic residue [active] 483219006476 Rdx family; Region: Rdx; pfam10262 483219006477 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 483219006478 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 483219006479 putative trimer interface [polypeptide binding]; other site 483219006480 putative CoA binding site [chemical binding]; other site 483219006481 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 483219006482 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 483219006483 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 483219006484 metal binding site [ion binding]; metal-binding site 483219006485 putative dimer interface [polypeptide binding]; other site 483219006486 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 483219006487 aromatic arch; other site 483219006488 DCoH dimer interaction site [polypeptide binding]; other site 483219006489 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 483219006490 DCoH tetramer interaction site [polypeptide binding]; other site 483219006491 substrate binding site [chemical binding]; other site 483219006492 Filamin/ABP280 repeat; Region: Filamin; pfam00630 483219006493 glycerol kinase; Provisional; Region: glpK; PRK00047 483219006494 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 483219006495 N- and C-terminal domain interface [polypeptide binding]; other site 483219006496 active site 483219006497 MgATP binding site [chemical binding]; other site 483219006498 catalytic site [active] 483219006499 metal binding site [ion binding]; metal-binding site 483219006500 glycerol binding site [chemical binding]; other site 483219006501 homotetramer interface [polypeptide binding]; other site 483219006502 homodimer interface [polypeptide binding]; other site 483219006503 FBP binding site [chemical binding]; other site 483219006504 protein IIAGlc interface [polypeptide binding]; other site 483219006505 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 483219006506 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 483219006507 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 483219006508 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 483219006509 FtsX-like permease family; Region: FtsX; pfam02687 483219006510 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 483219006511 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 483219006512 Walker A/P-loop; other site 483219006513 ATP binding site [chemical binding]; other site 483219006514 Q-loop/lid; other site 483219006515 ABC transporter signature motif; other site 483219006516 Walker B; other site 483219006517 D-loop; other site 483219006518 H-loop/switch region; other site 483219006519 Esterase/lipase [General function prediction only]; Region: COG1647 483219006520 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 483219006521 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 483219006522 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 483219006523 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 483219006524 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 483219006525 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 483219006526 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 483219006527 DNA binding residues [nucleotide binding] 483219006528 Putative zinc-finger; Region: zf-HC2; pfam13490 483219006529 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 483219006530 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 483219006531 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 483219006532 putative active site [active] 483219006533 putative active site [active] 483219006534 catalytic site [active] 483219006535 catalytic site [active] 483219006536 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 483219006537 putative active site [active] 483219006538 catalytic site [active] 483219006539 Penicillinase repressor; Region: Pencillinase_R; pfam03965 483219006540 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 483219006541 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 483219006542 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 483219006543 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219006544 TPR motif; other site 483219006545 binding surface 483219006546 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219006547 binding surface 483219006548 Tetratricopeptide repeat; Region: TPR_16; pfam13432 483219006549 TPR motif; other site 483219006550 Transcriptional regulator [Transcription]; Region: LysR; COG0583 483219006551 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 483219006552 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 483219006553 dimerization interface [polypeptide binding]; other site 483219006554 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 483219006555 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 483219006556 NAD(P) binding site [chemical binding]; other site 483219006557 active site 483219006558 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 483219006559 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 483219006560 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 483219006561 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 483219006562 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 483219006563 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 483219006564 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; cl09881 483219006565 Transglycosylase; Region: Transgly; cl17702 483219006566 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219006567 dimerization interface [polypeptide binding]; other site 483219006568 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219006569 dimerization interface [polypeptide binding]; other site 483219006570 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 483219006571 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219006572 dimerization interface [polypeptide binding]; other site 483219006573 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219006574 dimerization interface [polypeptide binding]; other site 483219006575 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219006576 dimerization interface [polypeptide binding]; other site 483219006577 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219006578 dimerization interface [polypeptide binding]; other site 483219006579 FOG: HAMP domain [Signal transduction mechanisms]; Region: ResE; COG2770 483219006580 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 483219006581 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219006582 dimerization interface [polypeptide binding]; other site 483219006583 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 483219006584 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219006585 dimerization interface [polypeptide binding]; other site 483219006586 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219006587 dimerization interface [polypeptide binding]; other site 483219006588 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219006589 dimerization interface [polypeptide binding]; other site 483219006590 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219006591 dimerization interface [polypeptide binding]; other site 483219006592 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219006593 dimerization interface [polypeptide binding]; other site 483219006594 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219006595 dimerization interface [polypeptide binding]; other site 483219006596 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219006597 dimerization interface [polypeptide binding]; other site 483219006598 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 483219006599 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219006600 dimerization interface [polypeptide binding]; other site 483219006601 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219006602 dimerization interface [polypeptide binding]; other site 483219006603 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219006604 dimerization interface [polypeptide binding]; other site 483219006605 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219006606 dimerization interface [polypeptide binding]; other site 483219006607 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219006608 dimerization interface [polypeptide binding]; other site 483219006609 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219006610 dimerization interface [polypeptide binding]; other site 483219006611 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219006612 dimerization interface [polypeptide binding]; other site 483219006613 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 483219006614 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219006615 dimerization interface [polypeptide binding]; other site 483219006616 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219006617 dimerization interface [polypeptide binding]; other site 483219006618 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219006619 dimerization interface [polypeptide binding]; other site 483219006620 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219006621 dimerization interface [polypeptide binding]; other site 483219006622 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219006623 dimerization interface [polypeptide binding]; other site 483219006624 GAF domain; Region: GAF_2; pfam13185 483219006625 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219006626 dimer interface [polypeptide binding]; other site 483219006627 phosphorylation site [posttranslational modification] 483219006628 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219006629 ATP binding site [chemical binding]; other site 483219006630 Mg2+ binding site [ion binding]; other site 483219006631 G-X-G motif; other site 483219006632 Response regulator receiver domain; Region: Response_reg; pfam00072 483219006633 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219006634 active site 483219006635 phosphorylation site [posttranslational modification] 483219006636 intermolecular recognition site; other site 483219006637 dimerization interface [polypeptide binding]; other site 483219006638 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219006639 phosphorylation site [posttranslational modification] 483219006640 intermolecular recognition site; other site 483219006641 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 483219006642 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219006643 active site 483219006644 phosphorylation site [posttranslational modification] 483219006645 intermolecular recognition site; other site 483219006646 dimerization interface [polypeptide binding]; other site 483219006647 Response regulator receiver domain; Region: Response_reg; pfam00072 483219006648 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219006649 active site 483219006650 phosphorylation site [posttranslational modification] 483219006651 intermolecular recognition site; other site 483219006652 dimerization interface [polypeptide binding]; other site 483219006653 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219006654 PAS domain; Region: PAS_9; pfam13426 483219006655 putative active site [active] 483219006656 heme pocket [chemical binding]; other site 483219006657 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 483219006658 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219006659 dimer interface [polypeptide binding]; other site 483219006660 phosphorylation site [posttranslational modification] 483219006661 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219006662 ATP binding site [chemical binding]; other site 483219006663 Mg2+ binding site [ion binding]; other site 483219006664 G-X-G motif; other site 483219006665 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 483219006666 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 483219006667 Caspase domain; Region: Peptidase_C14; pfam00656 483219006668 Bacterial Ig-like domain; Region: Big_5; pfam13205 483219006669 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 483219006670 EamA-like transporter family; Region: EamA; pfam00892 483219006671 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 483219006672 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 483219006673 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 483219006674 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 483219006675 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 483219006676 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 483219006677 protein binding site [polypeptide binding]; other site 483219006678 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 483219006679 putative lipid kinase; Reviewed; Region: PRK13057 483219006680 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 483219006681 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 483219006682 motif II; other site 483219006683 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 483219006684 Peptidase family M50; Region: Peptidase_M50; pfam02163 483219006685 active site 483219006686 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 483219006687 putative substrate binding region [chemical binding]; other site 483219006688 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 483219006689 DEAD/DEAH box helicase; Region: DEAD; pfam00270 483219006690 DEAD_2; Region: DEAD_2; pfam06733 483219006691 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 483219006692 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 483219006693 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 483219006694 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 483219006695 active site 483219006696 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 483219006697 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 483219006698 active site 483219006699 PS-10 peptidase S37; Region: Peptidase_S37; pfam05576 483219006700 RecX family; Region: RecX; pfam02631 483219006701 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 483219006702 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 483219006703 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 483219006704 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 483219006705 Walker A motif; other site 483219006706 ATP binding site [chemical binding]; other site 483219006707 Walker B motif; other site 483219006708 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 483219006709 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 483219006710 Walker A motif; other site 483219006711 ATP binding site [chemical binding]; other site 483219006712 Walker B motif; other site 483219006713 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 483219006714 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 483219006715 Coenzyme A binding pocket [chemical binding]; other site 483219006716 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 483219006717 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 483219006718 G1 box; other site 483219006719 GTP/Mg2+ binding site [chemical binding]; other site 483219006720 G2 box; other site 483219006721 Switch I region; other site 483219006722 G3 box; other site 483219006723 Switch II region; other site 483219006724 G4 box; other site 483219006725 G5 box; other site 483219006726 Sensory domain found in PocR; Region: PocR; pfam10114 483219006727 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219006728 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219006729 dimer interface [polypeptide binding]; other site 483219006730 phosphorylation site [posttranslational modification] 483219006731 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219006732 ATP binding site [chemical binding]; other site 483219006733 Mg2+ binding site [ion binding]; other site 483219006734 G-X-G motif; other site 483219006735 LabA_like proteins; Region: LabA_like; cd06167 483219006736 putative metal binding site [ion binding]; other site 483219006737 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 483219006738 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 483219006739 thiamine monophosphate kinase; Provisional; Region: PRK05731 483219006740 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 483219006741 ATP binding site [chemical binding]; other site 483219006742 dimerization interface [polypeptide binding]; other site 483219006743 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219006744 dimerization interface [polypeptide binding]; other site 483219006745 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 483219006746 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 483219006747 dimer interface [polypeptide binding]; other site 483219006748 putative CheW interface [polypeptide binding]; other site 483219006749 Protein of unknown function (DUF419); Region: DUF419; pfam04237 483219006750 CheW-like domain; Region: CheW; pfam01584 483219006751 Response regulator receiver domain; Region: Response_reg; pfam00072 483219006752 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219006753 active site 483219006754 phosphorylation site [posttranslational modification] 483219006755 intermolecular recognition site; other site 483219006756 dimerization interface [polypeptide binding]; other site 483219006757 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 483219006758 putative binding surface; other site 483219006759 active site 483219006760 P2 response regulator binding domain; Region: P2; pfam07194 483219006761 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 483219006762 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219006763 ATP binding site [chemical binding]; other site 483219006764 Mg2+ binding site [ion binding]; other site 483219006765 G-X-G motif; other site 483219006766 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 483219006767 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 483219006768 CheC-like family; Region: CheC; pfam04509 483219006769 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 483219006770 AIR carboxylase; Region: AIRC; smart01001 483219006771 Protein of unknown function DUF111; Region: DUF111; pfam01969 483219006772 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 483219006773 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 483219006774 ligand binding site [chemical binding]; other site 483219006775 flexible hinge region; other site 483219006776 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219006777 ATP binding site [chemical binding]; other site 483219006778 Mg2+ binding site [ion binding]; other site 483219006779 G-X-G motif; other site 483219006780 Receptor L domain; Region: Recep_L_domain; pfam01030 483219006781 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 483219006782 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 483219006783 DDE superfamily endonuclease; Region: DDE_3; pfam13358 483219006784 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 483219006785 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 483219006786 putative catalytic site [active] 483219006787 putative metal binding site [ion binding]; other site 483219006788 putative phosphate binding site [ion binding]; other site 483219006789 Lamin Tail Domain; Region: LTD; pfam00932 483219006790 GrpE; Region: GrpE; pfam01025 483219006791 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 483219006792 dimer interface [polypeptide binding]; other site 483219006793 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 483219006794 GrpE; Region: GrpE; pfam01025 483219006795 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 483219006796 dimer interface [polypeptide binding]; other site 483219006797 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 483219006798 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 483219006799 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 483219006800 nucleotide binding site [chemical binding]; other site 483219006801 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 483219006802 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219006803 active site 483219006804 ATP binding site [chemical binding]; other site 483219006805 substrate binding site [chemical binding]; other site 483219006806 activation loop (A-loop); other site 483219006807 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 483219006808 Domain of unknown function (DUF2382); Region: DUF2382; cl01590 483219006809 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 483219006810 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 483219006811 putative ligand binding site [chemical binding]; other site 483219006812 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 483219006813 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 483219006814 TM-ABC transporter signature motif; other site 483219006815 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 483219006816 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 483219006817 TM-ABC transporter signature motif; other site 483219006818 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 483219006819 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 483219006820 Walker A/P-loop; other site 483219006821 ATP binding site [chemical binding]; other site 483219006822 Q-loop/lid; other site 483219006823 ABC transporter signature motif; other site 483219006824 Walker B; other site 483219006825 D-loop; other site 483219006826 H-loop/switch region; other site 483219006827 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 483219006828 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 483219006829 Walker A/P-loop; other site 483219006830 ATP binding site [chemical binding]; other site 483219006831 Q-loop/lid; other site 483219006832 ABC transporter signature motif; other site 483219006833 Walker B; other site 483219006834 D-loop; other site 483219006835 H-loop/switch region; other site 483219006836 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 483219006837 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219006838 S-adenosylmethionine binding site [chemical binding]; other site 483219006839 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 483219006840 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 483219006841 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 483219006842 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 483219006843 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 483219006844 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 483219006845 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 483219006846 cyclase homology domain; Region: CHD; cd07302 483219006847 nucleotidyl binding site; other site 483219006848 metal binding site [ion binding]; metal-binding site 483219006849 dimer interface [polypeptide binding]; other site 483219006850 prolyl-tRNA synthetase; Provisional; Region: PRK08661 483219006851 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 483219006852 dimer interface [polypeptide binding]; other site 483219006853 motif 1; other site 483219006854 active site 483219006855 motif 2; other site 483219006856 motif 3; other site 483219006857 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 483219006858 anticodon binding site; other site 483219006859 zinc-binding site [ion binding]; other site 483219006860 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 483219006861 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 483219006862 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 483219006863 putative catalytic site [active] 483219006864 putative metal binding site [ion binding]; other site 483219006865 putative phosphate binding site [ion binding]; other site 483219006866 HNH endonuclease; Region: HNH_2; pfam13391 483219006867 TIGR02646 family protein; Region: TIGR02646 483219006868 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 483219006869 Methyltransferase domain; Region: Methyltransf_26; pfam13659 483219006870 DEAD-like helicases superfamily; Region: DEXDc; smart00487 483219006871 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 483219006872 ATP binding site [chemical binding]; other site 483219006873 putative Mg++ binding site [ion binding]; other site 483219006874 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 483219006875 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 483219006876 nucleotide binding region [chemical binding]; other site 483219006877 ATP-binding site [chemical binding]; other site 483219006878 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 483219006879 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 483219006880 ATP binding site [chemical binding]; other site 483219006881 putative Mg++ binding site [ion binding]; other site 483219006882 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 483219006883 ATP-binding site [chemical binding]; other site 483219006884 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 483219006885 DNA binding domain, excisionase family; Region: excise; TIGR01764 483219006886 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 483219006887 putative active site [active] 483219006888 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 483219006889 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 483219006890 protein binding site [polypeptide binding]; other site 483219006891 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 483219006892 protein binding site [polypeptide binding]; other site 483219006893 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 483219006894 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 483219006895 putative DNA binding site [nucleotide binding]; other site 483219006896 putative Zn2+ binding site [ion binding]; other site 483219006897 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 483219006898 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 483219006899 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 483219006900 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483219006901 putative PBP binding loops; other site 483219006902 ABC-ATPase subunit interface; other site 483219006903 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 483219006904 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219006905 Walker A/P-loop; other site 483219006906 ATP binding site [chemical binding]; other site 483219006907 Q-loop/lid; other site 483219006908 ABC transporter signature motif; other site 483219006909 Walker B; other site 483219006910 D-loop; other site 483219006911 H-loop/switch region; other site 483219006912 TOBE domain; Region: TOBE; cl01440 483219006913 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105 483219006914 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 483219006915 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 483219006916 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 483219006917 malonyl-CoA binding site [chemical binding]; other site 483219006918 dimer interface [polypeptide binding]; other site 483219006919 active site 483219006920 product binding site; other site 483219006921 Phospholipid methyltransferase; Region: PEMT; cl17370 483219006922 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 483219006923 potential frameshift: common BLAST hit: gi|108763733|ref|YP_634753.1| AMP-binding protein 483219006924 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 483219006925 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 483219006926 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 483219006927 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 483219006928 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 483219006929 short chain dehydrogenase; Provisional; Region: PRK07102 483219006930 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 483219006931 NAD(P) binding site [chemical binding]; other site 483219006932 active site 483219006933 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 483219006934 FAD binding domain; Region: FAD_binding_4; pfam01565 483219006935 hypothetical protein; Validated; Region: PRK08238 483219006936 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 483219006937 Methyltransferase domain; Region: Methyltransf_23; pfam13489 483219006938 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219006939 S-adenosylmethionine binding site [chemical binding]; other site 483219006940 Response regulator receiver domain; Region: Response_reg; pfam00072 483219006941 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219006942 active site 483219006943 phosphorylation site [posttranslational modification] 483219006944 intermolecular recognition site; other site 483219006945 dimerization interface [polypeptide binding]; other site 483219006946 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 483219006947 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 483219006948 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 483219006949 catalytic triad [active] 483219006950 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 483219006951 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 483219006952 Response regulator receiver domain; Region: Response_reg; pfam00072 483219006953 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219006954 active site 483219006955 phosphorylation site [posttranslational modification] 483219006956 intermolecular recognition site; other site 483219006957 dimerization interface [polypeptide binding]; other site 483219006958 circadian clock protein KaiC; Reviewed; Region: PRK09302 483219006959 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 483219006960 Walker A motif; other site 483219006961 ATP binding site [chemical binding]; other site 483219006962 Walker B motif; other site 483219006963 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 483219006964 Walker A motif; other site 483219006965 ATP binding site [chemical binding]; other site 483219006966 Walker B motif; other site 483219006967 Carbohydrate binding domain (family 25); Region: CBM_25; cl04060 483219006968 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 483219006969 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 483219006970 ATP binding site [chemical binding]; other site 483219006971 Mg++ binding site [ion binding]; other site 483219006972 motif III; other site 483219006973 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 483219006974 nucleotide binding region [chemical binding]; other site 483219006975 ATP-binding site [chemical binding]; other site 483219006976 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 483219006977 putative RNA binding site [nucleotide binding]; other site 483219006978 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 483219006979 G1 box; other site 483219006980 GTP/Mg2+ binding site [chemical binding]; other site 483219006981 G2 box; other site 483219006982 Switch I region; other site 483219006983 G3 box; other site 483219006984 Switch II region; other site 483219006985 G4 box; other site 483219006986 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 483219006987 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 483219006988 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 483219006989 NAD binding site [chemical binding]; other site 483219006990 catalytic Zn binding site [ion binding]; other site 483219006991 structural Zn binding site [ion binding]; other site 483219006992 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 483219006993 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 483219006994 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 483219006995 conserved hypothetical protein; Region: TIGR02270 483219006996 N-terminal double-transmembrane domain; Region: two_anch; TIGR02226 483219006997 von Willebrand factor type A domain; Region: VWA_2; pfam13519 483219006998 CARDB; Region: CARDB; pfam07705 483219006999 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 483219007000 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 483219007001 Protein of unknown function DUF58; Region: DUF58; pfam01882 483219007002 von Willebrand factor type A domain; Region: VWA_2; pfam13519 483219007003 MoxR-like ATPases [General function prediction only]; Region: COG0714 483219007004 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219007005 Walker A motif; other site 483219007006 ATP binding site [chemical binding]; other site 483219007007 Walker B motif; other site 483219007008 arginine finger; other site 483219007009 enoyl-CoA hydratase; Provisional; Region: PRK09245 483219007010 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 483219007011 substrate binding site [chemical binding]; other site 483219007012 oxyanion hole (OAH) forming residues; other site 483219007013 trimer interface [polypeptide binding]; other site 483219007014 YceG-like family; Region: YceG; pfam02618 483219007015 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 483219007016 dimerization interface [polypeptide binding]; other site 483219007017 Myxococcus xanthus paralogous domain TIGR02266; Region: gmx_TIGR02266 483219007018 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 483219007019 nucleotide binding site [chemical binding]; other site 483219007020 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 483219007021 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 483219007022 catalytic residues [active] 483219007023 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 483219007024 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 483219007025 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 483219007026 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 483219007027 Salmonella virulence plasmid 65kDa B protein; Region: SpvB; pfam03534 483219007028 Family description; Region: VCBS; pfam13517 483219007029 Family description; Region: VCBS; pfam13517 483219007030 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 483219007031 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 483219007032 RHS Repeat; Region: RHS_repeat; pfam05593 483219007033 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 483219007034 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 483219007035 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 483219007036 linker region; other site 483219007037 Transcriptional regulators [Transcription]; Region: MarR; COG1846 483219007038 MarR family; Region: MarR_2; pfam12802 483219007039 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 483219007040 putative hydrophobic ligand binding site [chemical binding]; other site 483219007041 CLM binding site; other site 483219007042 L1 loop; other site 483219007043 DNA binding site [nucleotide binding] 483219007044 NAD:arginine ADP-ribosyltransferase; Region: ART; pfam01129 483219007045 Peptidase family C69; Region: Peptidase_C69; cl17793 483219007046 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 483219007047 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 483219007048 PAS domain; Region: PAS_9; pfam13426 483219007049 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219007050 putative active site [active] 483219007051 heme pocket [chemical binding]; other site 483219007052 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 483219007053 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219007054 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219007055 dimer interface [polypeptide binding]; other site 483219007056 phosphorylation site [posttranslational modification] 483219007057 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219007058 ATP binding site [chemical binding]; other site 483219007059 Mg2+ binding site [ion binding]; other site 483219007060 G-X-G motif; other site 483219007061 Uncharacterized conserved protein [Function unknown]; Region: COG3287 483219007062 FIST N domain; Region: FIST; pfam08495 483219007063 FIST C domain; Region: FIST_C; pfam10442 483219007064 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 483219007065 phosphopeptide binding site; other site 483219007066 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 483219007067 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 483219007068 N-terminal plug; other site 483219007069 ligand-binding site [chemical binding]; other site 483219007070 Stigma-specific protein, Stig1; Region: Stig1; pfam04885 483219007071 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 483219007072 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 483219007073 intersubunit interface [polypeptide binding]; other site 483219007074 FecCD transport family; Region: FecCD; pfam01032 483219007075 ABC-ATPase subunit interface; other site 483219007076 dimer interface [polypeptide binding]; other site 483219007077 putative PBP binding regions; other site 483219007078 hypothetical protein; Provisional; Region: PHA03169 483219007079 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 483219007080 iron-sulfur cluster [ion binding]; other site 483219007081 [2Fe-2S] cluster binding site [ion binding]; other site 483219007082 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 483219007083 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 483219007084 phosphopeptide binding site; other site 483219007085 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 483219007086 cyclase homology domain; Region: CHD; cd07302 483219007087 nucleotidyl binding site; other site 483219007088 metal binding site [ion binding]; metal-binding site 483219007089 dimer interface [polypeptide binding]; other site 483219007090 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219007091 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219007092 active site 483219007093 ATP binding site [chemical binding]; other site 483219007094 substrate binding site [chemical binding]; other site 483219007095 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 483219007096 activation loop (A-loop); other site 483219007097 activation loop (A-loop); other site 483219007098 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 483219007099 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 483219007100 Walker A/P-loop; other site 483219007101 ATP binding site [chemical binding]; other site 483219007102 Q-loop/lid; other site 483219007103 ABC transporter signature motif; other site 483219007104 Walker B; other site 483219007105 D-loop; other site 483219007106 H-loop/switch region; other site 483219007107 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 483219007108 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 483219007109 nucleotide binding site/active site [active] 483219007110 HIT family signature motif; other site 483219007111 catalytic residue [active] 483219007112 HPr kinase/phosphorylase; Provisional; Region: PRK05428 483219007113 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 483219007114 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 483219007115 Hpr binding site; other site 483219007116 active site 483219007117 homohexamer subunit interaction site [polypeptide binding]; other site 483219007118 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 483219007119 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 483219007120 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219007121 active site 483219007122 ATP binding site [chemical binding]; other site 483219007123 substrate binding site [chemical binding]; other site 483219007124 activation loop (A-loop); other site 483219007125 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 483219007126 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 483219007127 beta-galactosidase; Region: BGL; TIGR03356 483219007128 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 483219007129 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 483219007130 Walker A/P-loop; other site 483219007131 ATP binding site [chemical binding]; other site 483219007132 Q-loop/lid; other site 483219007133 ABC transporter signature motif; other site 483219007134 Walker B; other site 483219007135 D-loop; other site 483219007136 H-loop/switch region; other site 483219007137 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 483219007138 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 483219007139 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483219007140 dimer interface [polypeptide binding]; other site 483219007141 conserved gate region; other site 483219007142 putative PBP binding loops; other site 483219007143 ABC-ATPase subunit interface; other site 483219007144 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 483219007145 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 483219007146 Walker A/P-loop; other site 483219007147 ATP binding site [chemical binding]; other site 483219007148 Q-loop/lid; other site 483219007149 ABC transporter signature motif; other site 483219007150 Walker B; other site 483219007151 D-loop; other site 483219007152 H-loop/switch region; other site 483219007153 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 483219007154 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 483219007155 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483219007156 dimer interface [polypeptide binding]; other site 483219007157 conserved gate region; other site 483219007158 putative PBP binding loops; other site 483219007159 ABC-ATPase subunit interface; other site 483219007160 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 483219007161 substrate binding site [chemical binding]; other site 483219007162 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 483219007163 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 483219007164 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 483219007165 active site 483219007166 catalytic residues [active] 483219007167 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 483219007168 putative DNA binding site [nucleotide binding]; other site 483219007169 putative Zn2+ binding site [ion binding]; other site 483219007170 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 483219007171 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 483219007172 nucleotide binding site [chemical binding]; other site 483219007173 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 483219007174 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 483219007175 putative active site [active] 483219007176 putative metal binding site [ion binding]; other site 483219007177 SPFH domain / Band 7 family; Region: Band_7; pfam01145 483219007178 NADH kinase; Region: PLN02929 483219007179 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 483219007180 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 483219007181 catalytic triad [active] 483219007182 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 483219007183 active pocket/dimerization site; other site 483219007184 active site 483219007185 phosphorylation site [posttranslational modification] 483219007186 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 483219007187 active site 483219007188 phosphorylation site [posttranslational modification] 483219007189 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 483219007190 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 483219007191 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 483219007192 dimerization domain swap beta strand [polypeptide binding]; other site 483219007193 regulatory protein interface [polypeptide binding]; other site 483219007194 active site 483219007195 regulatory phosphorylation site [posttranslational modification]; other site 483219007196 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 483219007197 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 483219007198 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 483219007199 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 483219007200 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 483219007201 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 483219007202 Protein of unknown function (DUF1826); Region: DUF1826; pfam08856 483219007203 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 483219007204 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 483219007205 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 483219007206 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 483219007207 MgtC family; Region: MgtC; pfam02308 483219007208 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 483219007209 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 483219007210 Site-specific recombinase; Region: SpecificRecomb; pfam10136 483219007211 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 483219007212 S-adenosylmethionine synthetase; Validated; Region: PRK05250 483219007213 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 483219007214 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 483219007215 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 483219007216 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 483219007217 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 483219007218 homotetramer interface [polypeptide binding]; other site 483219007219 ligand binding site [chemical binding]; other site 483219007220 catalytic site [active] 483219007221 NAD binding site [chemical binding]; other site 483219007222 hypothetical protein; Provisional; Region: PRK01842 483219007223 SEC-C motif; Region: SEC-C; pfam02810 483219007224 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 483219007225 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 483219007226 putative active site [active] 483219007227 putative CoA binding site [chemical binding]; other site 483219007228 nudix motif; other site 483219007229 metal binding site [ion binding]; metal-binding site 483219007230 Homeodomain-like domain; Region: HTH_23; cl17451 483219007231 Transposase domain (DUF772); Region: DUF772; pfam05598 483219007232 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 483219007233 putative active site [active] 483219007234 putative CoA binding site [chemical binding]; other site 483219007235 nudix motif; other site 483219007236 metal binding site [ion binding]; metal-binding site 483219007237 Helix-turn-helix domain; Region: HTH_28; pfam13518 483219007238 Winged helix-turn helix; Region: HTH_29; pfam13551 483219007239 Transposase domain (DUF772); Region: DUF772; pfam05598 483219007240 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 483219007241 Uncharacterized conserved protein [Function unknown]; Region: COG2966 483219007242 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 483219007243 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 483219007244 Sulfatase; Region: Sulfatase; pfam00884 483219007245 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 483219007246 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 483219007247 Sulfate transporter family; Region: Sulfate_transp; pfam00916 483219007248 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 483219007249 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 483219007250 Predicted membrane protein [Function unknown]; Region: COG4325 483219007251 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 483219007252 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 483219007253 active site 483219007254 oxyanion hole [active] 483219007255 catalytic triad [active] 483219007256 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 483219007257 SGNH_peri1; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri1; cd01825 483219007258 active site 483219007259 oxyanion hole [active] 483219007260 catalytic triad [active] 483219007261 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 483219007262 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 483219007263 Substrate binding site; other site 483219007264 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219007265 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219007266 active site 483219007267 ATP binding site [chemical binding]; other site 483219007268 substrate binding site [chemical binding]; other site 483219007269 activation loop (A-loop); other site 483219007270 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 483219007271 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 483219007272 active site 483219007273 substrate binding site [chemical binding]; other site 483219007274 metal binding site [ion binding]; metal-binding site 483219007275 Predicted flavoprotein [General function prediction only]; Region: COG0431 483219007276 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 483219007277 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 483219007278 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 483219007279 nucleotide binding site [chemical binding]; other site 483219007280 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 483219007281 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 483219007282 dimer interface [polypeptide binding]; other site 483219007283 catalytic triad [active] 483219007284 peroxidatic and resolving cysteines [active] 483219007285 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 483219007286 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 483219007287 active site 483219007288 metal binding site [ion binding]; metal-binding site 483219007289 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 483219007290 Peptidase family M23; Region: Peptidase_M23; pfam01551 483219007291 HEAT repeats; Region: HEAT_2; pfam13646 483219007292 HEAT repeats; Region: HEAT_2; pfam13646 483219007293 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 483219007294 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 483219007295 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 483219007296 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 483219007297 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 483219007298 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 483219007299 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 483219007300 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 483219007301 motif II; other site 483219007302 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 483219007303 Protein of unknown function, DUF547; Region: DUF547; pfam04784 483219007304 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 483219007305 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 483219007306 iron-sulfur cluster [ion binding]; other site 483219007307 [2Fe-2S] cluster binding site [ion binding]; other site 483219007308 Outer membrane efflux protein; Region: OEP; pfam02321 483219007309 Outer membrane efflux protein; Region: OEP; pfam02321 483219007310 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 483219007311 MarR family; Region: MarR; pfam01047 483219007312 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 483219007313 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 483219007314 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 483219007315 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 483219007316 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 483219007317 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 483219007318 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 483219007319 active site 483219007320 catalytic tetrad [active] 483219007321 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 483219007322 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 483219007323 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219007324 Walker A motif; other site 483219007325 ATP binding site [chemical binding]; other site 483219007326 Walker B motif; other site 483219007327 arginine finger; other site 483219007328 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 483219007329 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 483219007330 Walker A/P-loop; other site 483219007331 ATP binding site [chemical binding]; other site 483219007332 Q-loop/lid; other site 483219007333 ABC transporter signature motif; other site 483219007334 Walker B; other site 483219007335 D-loop; other site 483219007336 H-loop/switch region; other site 483219007337 Protein of unknown function DUF58; Region: DUF58; pfam01882 483219007338 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 483219007339 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 483219007340 metal ion-dependent adhesion site (MIDAS); other site 483219007341 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 483219007342 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 483219007343 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 483219007344 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 483219007345 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 483219007346 catalytic residues [active] 483219007347 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 483219007348 LysR family transcriptional regulator; Provisional; Region: PRK14997 483219007349 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 483219007350 dimerization interface [polypeptide binding]; other site 483219007351 putative effector binding pocket; other site 483219007352 Family of unknown function (DUF490); Region: DUF490; pfam04357 483219007353 Surface antigen; Region: Bac_surface_Ag; pfam01103 483219007354 4-alpha-glucanotransferase; Provisional; Region: PRK14508 483219007355 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 483219007356 active site 483219007357 DNA binding site [nucleotide binding] 483219007358 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 483219007359 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 483219007360 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 483219007361 DNA binding residues [nucleotide binding] 483219007362 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 483219007363 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14470 483219007364 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 483219007365 FeS/SAM binding site; other site 483219007366 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 483219007367 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 483219007368 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219007369 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 483219007370 Walker A motif; other site 483219007371 ATP binding site [chemical binding]; other site 483219007372 Walker B motif; other site 483219007373 arginine finger; other site 483219007374 Winged helix-turn helix; Region: HTH_29; pfam13551 483219007375 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 483219007376 Integrase core domain; Region: rve; pfam00665 483219007377 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 483219007378 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 483219007379 dimer interface [polypeptide binding]; other site 483219007380 putative CheW interface [polypeptide binding]; other site 483219007381 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 483219007382 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 483219007383 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 483219007384 Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958 483219007385 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 483219007386 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 483219007387 Beta-lactamase; Region: Beta-lactamase; pfam00144 483219007388 B12-binding domain/radical SAM domain protein, MJ_1487 family; Region: B12_SAM_MJ_1487; TIGR04013 483219007389 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 483219007390 Predicted lipoprotein of unknown function (DUF2380); Region: DUF2380; pfam09533 483219007391 Protein of unknown function (Gmx_para_CXXCG); Region: Gmx_para_CXXCG; cl15282 483219007392 isocitrate lyase; Provisional; Region: PRK15063 483219007393 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 483219007394 tetramer interface [polypeptide binding]; other site 483219007395 active site 483219007396 Mg2+/Mn2+ binding site [ion binding]; other site 483219007397 malate synthase A; Region: malate_syn_A; TIGR01344 483219007398 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 483219007399 active site 483219007400 PspC domain; Region: PspC; pfam04024 483219007401 fumarate hydratase; Reviewed; Region: fumC; PRK00485 483219007402 Class II fumarases; Region: Fumarase_classII; cd01362 483219007403 active site 483219007404 tetramer interface [polypeptide binding]; other site 483219007405 Clp protease; Region: CLP_protease; pfam00574 483219007406 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 483219007407 oligomer interface [polypeptide binding]; other site 483219007408 active site residues [active] 483219007409 Protein of unknown function (DUF3293); Region: DUF3293; pfam11697 483219007410 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 483219007411 Peptidase family M48; Region: Peptidase_M48; pfam01435 483219007412 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 483219007413 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 483219007414 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 483219007415 active site 483219007416 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 483219007417 PLD-like domain; Region: PLDc_2; pfam13091 483219007418 putative active site [active] 483219007419 catalytic site [active] 483219007420 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 483219007421 PLD-like domain; Region: PLDc_2; pfam13091 483219007422 putative active site [active] 483219007423 catalytic site [active] 483219007424 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 483219007425 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 483219007426 minor groove reading motif; other site 483219007427 helix-hairpin-helix signature motif; other site 483219007428 substrate binding pocket [chemical binding]; other site 483219007429 active site 483219007430 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 483219007431 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 483219007432 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 483219007433 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219007434 active site 483219007435 ATP binding site [chemical binding]; other site 483219007436 substrate binding site [chemical binding]; other site 483219007437 activation loop (A-loop); other site 483219007438 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 483219007439 NlpC/P60 family; Region: NLPC_P60; cl17555 483219007440 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219007441 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219007442 active site 483219007443 ATP binding site [chemical binding]; other site 483219007444 substrate binding site [chemical binding]; other site 483219007445 activation loop (A-loop); other site 483219007446 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 483219007447 cyclase homology domain; Region: CHD; cd07302 483219007448 nucleotidyl binding site; other site 483219007449 metal binding site [ion binding]; metal-binding site 483219007450 dimer interface [polypeptide binding]; other site 483219007451 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219007452 TPR motif; other site 483219007453 binding surface 483219007454 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 483219007455 Ligand Binding Site [chemical binding]; other site 483219007456 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 483219007457 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 483219007458 von Willebrand factor; Region: vWF_A; pfam12450 483219007459 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 483219007460 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219007461 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219007462 dimer interface [polypeptide binding]; other site 483219007463 phosphorylation site [posttranslational modification] 483219007464 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219007465 ATP binding site [chemical binding]; other site 483219007466 G-X-G motif; other site 483219007467 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 483219007468 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219007469 active site 483219007470 phosphorylation site [posttranslational modification] 483219007471 intermolecular recognition site; other site 483219007472 dimerization interface [polypeptide binding]; other site 483219007473 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 483219007474 DNA binding site [nucleotide binding] 483219007475 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 483219007476 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 483219007477 putative acyltransferase; Provisional; Region: PRK05790 483219007478 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 483219007479 dimer interface [polypeptide binding]; other site 483219007480 active site 483219007481 Coenzyme A transferase; Region: CoA_trans; cl17247 483219007482 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 483219007483 4-aminobutyrate aminotransferase; Provisional; Region: PRK05769 483219007484 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 483219007485 inhibitor-cofactor binding pocket; inhibition site 483219007486 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483219007487 catalytic residue [active] 483219007488 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 483219007489 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 483219007490 NAD(P) binding site [chemical binding]; other site 483219007491 catalytic residues [active] 483219007492 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 483219007493 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 483219007494 inhibitor-cofactor binding pocket; inhibition site 483219007495 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483219007496 catalytic residue [active] 483219007497 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 483219007498 type 2 lantibiotic, mersacidin/lichenicidin family; Region: lanti_MRSA_kill; TIGR03898 483219007499 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 483219007500 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 483219007501 active site 483219007502 zinc binding site [ion binding]; other site 483219007503 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 483219007504 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 483219007505 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 483219007506 active site 483219007507 catalytic tetrad [active] 483219007508 5'-methylthioadenosine phosphorylase; Provisional; Region: PRK08931 483219007509 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 483219007510 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 483219007511 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 483219007512 intersubunit interface [polypeptide binding]; other site 483219007513 active site 483219007514 Zn2+ binding site [ion binding]; other site 483219007515 phosphodiesterase YaeI; Provisional; Region: PRK11340 483219007516 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 483219007517 putative active site [active] 483219007518 putative metal binding site [ion binding]; other site 483219007519 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 483219007520 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 483219007521 phosphopeptide binding site; other site 483219007522 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 483219007523 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 483219007524 dimer interface [polypeptide binding]; other site 483219007525 acyl-activating enzyme (AAE) consensus motif; other site 483219007526 putative active site [active] 483219007527 AMP binding site [chemical binding]; other site 483219007528 putative CoA binding site [chemical binding]; other site 483219007529 6-phosphofructokinase; Provisional; Region: PRK03202 483219007530 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 483219007531 active site 483219007532 ADP/pyrophosphate binding site [chemical binding]; other site 483219007533 dimerization interface [polypeptide binding]; other site 483219007534 allosteric effector site; other site 483219007535 fructose-1,6-bisphosphate binding site; other site 483219007536 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 483219007537 Amidase; Region: Amidase; pfam01425 483219007538 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 483219007539 active site 483219007540 trimer interface [polypeptide binding]; other site 483219007541 allosteric site; other site 483219007542 active site lid [active] 483219007543 hexamer (dimer of trimers) interface [polypeptide binding]; other site 483219007544 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 483219007545 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 483219007546 N-acetyl-D-glucosamine binding site [chemical binding]; other site 483219007547 catalytic residue [active] 483219007548 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 483219007549 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 483219007550 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 483219007551 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 483219007552 Peptidase family M28; Region: Peptidase_M28; pfam04389 483219007553 metal binding site [ion binding]; metal-binding site 483219007554 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 483219007555 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 483219007556 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 483219007557 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 483219007558 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 483219007559 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 483219007560 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 483219007561 FAD binding domain; Region: FAD_binding_4; pfam01565 483219007562 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 483219007563 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 483219007564 ligand binding site [chemical binding]; other site 483219007565 NAD binding site [chemical binding]; other site 483219007566 tetramer interface [polypeptide binding]; other site 483219007567 catalytic site [active] 483219007568 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 483219007569 L-serine binding site [chemical binding]; other site 483219007570 ACT domain interface; other site 483219007571 Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cl17349 483219007572 active site 483219007573 Zn binding site [ion binding]; other site 483219007574 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 483219007575 active site 483219007576 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 483219007577 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 483219007578 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 483219007579 maleylacetoacetate isomerase; Region: maiA; TIGR01262 483219007580 C-terminal domain interface [polypeptide binding]; other site 483219007581 GSH binding site (G-site) [chemical binding]; other site 483219007582 putative dimer interface [polypeptide binding]; other site 483219007583 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 483219007584 dimer interface [polypeptide binding]; other site 483219007585 N-terminal domain interface [polypeptide binding]; other site 483219007586 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 483219007587 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 483219007588 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 483219007589 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 483219007590 Cupin domain; Region: Cupin_2; pfam07883 483219007591 Vitamin K epoxide reductase family in bacteria; Region: VKOR_3; cd12920 483219007592 putative active site [active] 483219007593 redox center [active] 483219007594 Thioredoxin; Region: Thioredoxin_4; cl17273 483219007595 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 483219007596 putative rRNA binding site [nucleotide binding]; other site 483219007597 Domain of unknown function (DUF2019); Region: DUF2019; pfam09450 483219007598 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 483219007599 tartrate dehydrogenase; Region: TTC; TIGR02089 483219007600 Predicted integral membrane protein (DUF2270); Region: DUF2270; pfam10028 483219007601 PAS domain; Region: PAS_9; pfam13426 483219007602 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219007603 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219007604 ATP binding site [chemical binding]; other site 483219007605 Mg2+ binding site [ion binding]; other site 483219007606 G-X-G motif; other site 483219007607 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219007608 active site 483219007609 phosphorylation site [posttranslational modification] 483219007610 intermolecular recognition site; other site 483219007611 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 483219007612 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 483219007613 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 483219007614 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 483219007615 non-specific DNA binding site [nucleotide binding]; other site 483219007616 salt bridge; other site 483219007617 sequence-specific DNA binding site [nucleotide binding]; other site 483219007618 Cupin domain; Region: Cupin_2; pfam07883 483219007619 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 483219007620 classical (c) SDRs; Region: SDR_c; cd05233 483219007621 NAD(P) binding site [chemical binding]; other site 483219007622 active site 483219007623 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 483219007624 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 483219007625 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 483219007626 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 483219007627 NAD binding site [chemical binding]; other site 483219007628 catalytic Zn binding site [ion binding]; other site 483219007629 structural Zn binding site [ion binding]; other site 483219007630 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 483219007631 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 483219007632 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 483219007633 Zn2+ binding site [ion binding]; other site 483219007634 Mg2+ binding site [ion binding]; other site 483219007635 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 483219007636 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 483219007637 PLD-like domain; Region: PLDc_2; pfam13091 483219007638 putative active site [active] 483219007639 catalytic site [active] 483219007640 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 483219007641 PLD-like domain; Region: PLDc_2; pfam13091 483219007642 putative active site [active] 483219007643 catalytic site [active] 483219007644 Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714 483219007645 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 483219007646 active site 483219007647 ATP binding site [chemical binding]; other site 483219007648 substrate binding site [chemical binding]; other site 483219007649 activation loop (A-loop); other site 483219007650 7-cyano-7-deazaguanine reductase; Region: QueF-II; TIGR03139 483219007651 GAF domain; Region: GAF_3; pfam13492 483219007652 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219007653 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219007654 ATP binding site [chemical binding]; other site 483219007655 Mg2+ binding site [ion binding]; other site 483219007656 G-X-G motif; other site 483219007657 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219007658 YdjC-like protein; Region: YdjC; pfam04794 483219007659 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 483219007660 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219007661 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219007662 active site 483219007663 ATP binding site [chemical binding]; other site 483219007664 substrate binding site [chemical binding]; other site 483219007665 activation loop (A-loop); other site 483219007666 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 483219007667 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219007668 binding surface 483219007669 TPR motif; other site 483219007670 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 483219007671 putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203 483219007672 active site 483219007673 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 483219007674 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 483219007675 catalytic triad [active] 483219007676 Predicted acetyltransferase [General function prediction only]; Region: COG5628 483219007677 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 483219007678 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 483219007679 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 483219007680 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 483219007681 Cl- selectivity filter; other site 483219007682 Cl- binding residues [ion binding]; other site 483219007683 pore gating glutamate residue; other site 483219007684 dimer interface [polypeptide binding]; other site 483219007685 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 483219007686 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 483219007687 Fatty acid desaturase; Region: FA_desaturase; pfam00487 483219007688 Di-iron ligands [ion binding]; other site 483219007689 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 483219007690 Peptidase family M50; Region: Peptidase_M50; pfam02163 483219007691 active site 483219007692 putative substrate binding region [chemical binding]; other site 483219007693 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 483219007694 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 483219007695 FMN binding site [chemical binding]; other site 483219007696 active site 483219007697 catalytic residues [active] 483219007698 substrate binding site [chemical binding]; other site 483219007699 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 483219007700 beta-galactosidase; Region: BGL; TIGR03356 483219007701 Domain of unknown function (DUF814); Region: DUF814; pfam05670 483219007702 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 483219007703 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 483219007704 active site 483219007705 domain interfaces; other site 483219007706 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 483219007707 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 483219007708 Zn2+ binding site [ion binding]; other site 483219007709 Mg2+ binding site [ion binding]; other site 483219007710 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 483219007711 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 483219007712 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 483219007713 substrate binding site [chemical binding]; other site 483219007714 hexamer interface [polypeptide binding]; other site 483219007715 metal binding site [ion binding]; metal-binding site 483219007716 Response regulator receiver domain; Region: Response_reg; pfam00072 483219007717 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219007718 active site 483219007719 phosphorylation site [posttranslational modification] 483219007720 intermolecular recognition site; other site 483219007721 dimerization interface [polypeptide binding]; other site 483219007722 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 483219007723 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 483219007724 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 483219007725 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 483219007726 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 483219007727 Protein of unknown function (DUF2379); Region: DUF2379; cl15283 483219007728 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 483219007729 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 483219007730 glycosyltransferase, MGT family; Region: MGT; TIGR01426 483219007731 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 483219007732 active site 483219007733 TDP-binding site; other site 483219007734 acceptor substrate-binding pocket; other site 483219007735 homodimer interface [polypeptide binding]; other site 483219007736 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 483219007737 putative catalytic residues [active] 483219007738 Transcriptional regulator [Transcription]; Region: LysR; COG0583 483219007739 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 483219007740 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 483219007741 substrate binding pocket [chemical binding]; other site 483219007742 dimerization interface [polypeptide binding]; other site 483219007743 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 483219007744 putative active site [active] 483219007745 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 483219007746 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 483219007747 A new structural DNA glycosylase; Region: AlkD_like; cd06561 483219007748 active site 483219007749 Ferritin-like; Region: Ferritin-like; pfam12902 483219007750 hypothetical protein; Provisional; Region: PRK05409 483219007751 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 483219007752 Phophatidylserine decarboxylase; Region: PSDC; pfam12588 483219007753 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 483219007754 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 483219007755 MarR family; Region: MarR; pfam01047 483219007756 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 483219007757 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 483219007758 Cl- selectivity filter; other site 483219007759 Cl- binding residues [ion binding]; other site 483219007760 pore gating glutamate residue; other site 483219007761 dimer interface [polypeptide binding]; other site 483219007762 FOG: CBS domain [General function prediction only]; Region: COG0517 483219007763 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 483219007764 Predicted transcriptional regulators [Transcription]; Region: COG1378 483219007765 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 483219007766 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 483219007767 C-terminal domain interface [polypeptide binding]; other site 483219007768 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 483219007769 catalytic motif [active] 483219007770 Catalytic residue [active] 483219007771 Aspartyl protease; Region: Asp_protease_2; pfam13650 483219007772 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 483219007773 protein binding site [polypeptide binding]; other site 483219007774 Beta-propeller repeat; Region: SBBP; pfam06739 483219007775 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219007776 S-adenosylmethionine binding site [chemical binding]; other site 483219007777 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 483219007778 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 483219007779 putative sugar binding sites [chemical binding]; other site 483219007780 Q-X-W motif; other site 483219007781 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 483219007782 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 483219007783 substrate binding pocket [chemical binding]; other site 483219007784 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 483219007785 Integrase core domain; Region: rve_3; cl15866 483219007786 Beta/Gamma crystallin; Region: Crystall; cl02528 483219007787 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 483219007788 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 483219007789 active site 483219007790 zinc binding site [ion binding]; other site 483219007791 hypothetical protein; Provisional; Region: PRK06185 483219007792 hypothetical protein; Provisional; Region: PRK07236 483219007793 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 483219007794 Protein of unknown function (DUF962); Region: DUF962; pfam06127 483219007795 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 483219007796 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 483219007797 FeS/SAM binding site; other site 483219007798 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 483219007799 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 483219007800 putative active site [active] 483219007801 putative NTP binding site [chemical binding]; other site 483219007802 putative nucleic acid binding site [nucleotide binding]; other site 483219007803 potential frameshift: common BLAST hit: gi|108763777|ref|YP_634389.1| SWIM zinc finger domain-containing protein 483219007804 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 483219007805 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 483219007806 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 483219007807 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 483219007808 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 483219007809 putative dimer interface [polypeptide binding]; other site 483219007810 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 483219007811 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 483219007812 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 483219007813 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 483219007814 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 483219007815 ligand binding site [chemical binding]; other site 483219007816 flexible hinge region; other site 483219007817 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 483219007818 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 483219007819 ligand binding site [chemical binding]; other site 483219007820 flexible hinge region; other site 483219007821 Non-plant Terpene Cyclases, Class 1; Region: Terpene_cyclase_nonplant_C1; cd00687 483219007822 substrate binding pocket [chemical binding]; other site 483219007823 substrate-Mg2+ binding site; other site 483219007824 aspartate-rich region 1; other site 483219007825 active site lid residues [active] 483219007826 aspartate-rich region 2; other site 483219007827 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 483219007828 substrate binding pocket [chemical binding]; other site 483219007829 substrate-Mg2+ binding site; other site 483219007830 aspartate-rich region 1; other site 483219007831 aspartate-rich region 2; other site 483219007832 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 483219007833 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 483219007834 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 483219007835 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 483219007836 conserved cys residue [active] 483219007837 Kelch domain; Region: Kelch; smart00612 483219007838 Galactose oxidase, central domain; Region: Kelch_3; cl02701 483219007839 Galactose oxidase, central domain; Region: Kelch_3; cl02701 483219007840 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 483219007841 HYR domain; Region: HYR; pfam02494 483219007842 HYR domain; Region: HYR; pfam02494 483219007843 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 483219007844 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 483219007845 ligand binding site [chemical binding]; other site 483219007846 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 483219007847 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 483219007848 dimer interface [polypeptide binding]; other site 483219007849 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219007850 S-adenosylmethionine binding site [chemical binding]; other site 483219007851 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 483219007852 Prokaryotic RING finger family 4; Region: Prok-RING_4; pfam14447 483219007853 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 483219007854 putative metal binding site [ion binding]; other site 483219007855 conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806 483219007856 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 483219007857 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219007858 active site 483219007859 phosphorylation site [posttranslational modification] 483219007860 intermolecular recognition site; other site 483219007861 dimerization interface [polypeptide binding]; other site 483219007862 Thiamine-precursor transporter protein (ThiW); Region: ThiW; cl01952 483219007863 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219007864 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 483219007865 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219007866 ATP binding site [chemical binding]; other site 483219007867 Mg2+ binding site [ion binding]; other site 483219007868 G-X-G motif; other site 483219007869 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 483219007870 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 483219007871 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 483219007872 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 483219007873 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 483219007874 NAD(P) binding site [chemical binding]; other site 483219007875 active site 483219007876 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 483219007877 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 483219007878 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 483219007879 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 483219007880 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 483219007881 tRNA synthetases class I (I, L, M and V); Region: tRNA-synt_1; pfam00133 483219007882 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 483219007883 active site 483219007884 HIGH motif; other site 483219007885 nucleotide binding site [chemical binding]; other site 483219007886 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 483219007887 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 483219007888 active site 483219007889 KMSKS motif; other site 483219007890 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 483219007891 tRNA binding surface [nucleotide binding]; other site 483219007892 anticodon binding site; other site 483219007893 Anticodon-binding domain of tRNA; Region: Anticodon_1; pfam08264 483219007894 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 483219007895 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 483219007896 active site 483219007897 substrate binding sites [chemical binding]; other site 483219007898 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 483219007899 dimerization interface [polypeptide binding]; other site 483219007900 putative DNA binding site [nucleotide binding]; other site 483219007901 putative Zn2+ binding site [ion binding]; other site 483219007902 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 483219007903 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 483219007904 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 483219007905 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 483219007906 short chain dehydrogenase; Provisional; Region: PRK06914 483219007907 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 483219007908 NADP binding site [chemical binding]; other site 483219007909 active site 483219007910 steroid binding site; other site 483219007911 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 483219007912 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 483219007913 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 483219007914 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 483219007915 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 483219007916 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 483219007917 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 483219007918 DNA binding residues [nucleotide binding] 483219007919 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 483219007920 AAA domain; Region: AAA_23; pfam13476 483219007921 AAA domain; Region: AAA_21; pfam13304 483219007922 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 483219007923 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 483219007924 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 483219007925 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 483219007926 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 483219007927 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 483219007928 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 483219007929 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 483219007930 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u2; cd11494 483219007931 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 483219007932 Na binding site [ion binding]; other site 483219007933 hydroperoxidase II; Provisional; Region: katE; PRK11249 483219007934 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 483219007935 tetramer interface [polypeptide binding]; other site 483219007936 heme binding pocket [chemical binding]; other site 483219007937 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 483219007938 domain interactions; other site 483219007939 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 483219007940 putative hydrophobic ligand binding site [chemical binding]; other site 483219007941 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 483219007942 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 483219007943 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 483219007944 Domain of unknown function (DUF4041); Region: DUF4041; pfam13250 483219007945 T5orf172 domain; Region: T5orf172; pfam10544 483219007946 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 483219007947 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219007948 active site 483219007949 ATP binding site [chemical binding]; other site 483219007950 substrate binding site [chemical binding]; other site 483219007951 activation loop (A-loop); other site 483219007952 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 483219007953 Coenzyme A binding pocket [chemical binding]; other site 483219007954 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 483219007955 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238 483219007956 dimer interface [polypeptide binding]; other site 483219007957 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 483219007958 Helix-turn-helix domain; Region: HTH_18; pfam12833 483219007959 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 483219007960 Protein kinase domain; Region: Pkinase; pfam00069 483219007961 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219007962 active site 483219007963 ATP binding site [chemical binding]; other site 483219007964 substrate binding site [chemical binding]; other site 483219007965 activation loop (A-loop); other site 483219007966 AAA ATPase domain; Region: AAA_16; pfam13191 483219007967 Uncharacterized conserved protein [Function unknown]; Region: COG1262 483219007968 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 483219007969 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 483219007970 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 483219007971 phosphopeptide binding site; other site 483219007972 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 483219007973 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219007974 Walker A motif; other site 483219007975 ATP binding site [chemical binding]; other site 483219007976 Walker B motif; other site 483219007977 arginine finger; other site 483219007978 Homeodomain-like domain; Region: HTH_23; pfam13384 483219007979 MAEBL; Provisional; Region: PTZ00121 483219007980 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 483219007981 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 483219007982 Immunoglobulin I-set domain; Region: I-set; pfam07679 483219007983 Immunoglobulin domain; Region: Ig_2; pfam13895 483219007984 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 483219007985 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 483219007986 Nuclease subunit of the excinuclease complex [DNA replication, recombination, and repair]; Region: UvrC; COG0322 483219007987 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 483219007988 GIY-YIG motif/motif A; other site 483219007989 active site 483219007990 catalytic site [active] 483219007991 putative DNA binding site [nucleotide binding]; other site 483219007992 metal binding site [ion binding]; metal-binding site 483219007993 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 483219007994 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 483219007995 active site 483219007996 glutathionine S-transferase; Provisional; Region: PRK10542 483219007997 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 483219007998 C-terminal domain interface [polypeptide binding]; other site 483219007999 GSH binding site (G-site) [chemical binding]; other site 483219008000 dimer interface [polypeptide binding]; other site 483219008001 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 483219008002 dimer interface [polypeptide binding]; other site 483219008003 N-terminal domain interface [polypeptide binding]; other site 483219008004 substrate binding pocket (H-site) [chemical binding]; other site 483219008005 TIGR02452 family protein; Region: TIGR02452 483219008006 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 483219008007 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 483219008008 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 483219008009 radical SAM/SPASM domain protein, GRRM system; Region: rSAM_GlyRichRpt; TIGR04261 483219008010 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 483219008011 FeS/SAM binding site; other site 483219008012 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 483219008013 PAS domain S-box; Region: sensory_box; TIGR00229 483219008014 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219008015 putative active site [active] 483219008016 heme pocket [chemical binding]; other site 483219008017 PAS fold; Region: PAS_3; pfam08447 483219008018 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219008019 putative active site [active] 483219008020 heme pocket [chemical binding]; other site 483219008021 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219008022 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219008023 ATP binding site [chemical binding]; other site 483219008024 Mg2+ binding site [ion binding]; other site 483219008025 G-X-G motif; other site 483219008026 cyclase homology domain; Region: CHD; cd07302 483219008027 nucleotidyl binding site; other site 483219008028 metal binding site [ion binding]; metal-binding site 483219008029 dimer interface [polypeptide binding]; other site 483219008030 AAA ATPase domain; Region: AAA_16; pfam13191 483219008031 NACHT domain; Region: NACHT; pfam05729 483219008032 Tetratricopeptide repeat; Region: TPR_12; pfam13424 483219008033 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 483219008034 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 483219008035 motif II; other site 483219008036 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 483219008037 Ligand binding site; other site 483219008038 metal-binding site 483219008039 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 483219008040 XdhC Rossmann domain; Region: XdhC_C; pfam13478 483219008041 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 483219008042 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 483219008043 NAD(P) binding site [chemical binding]; other site 483219008044 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 483219008045 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 483219008046 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 483219008047 active site 483219008048 Zn binding site [ion binding]; other site 483219008049 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 483219008050 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 483219008051 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 483219008052 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 483219008053 active site 483219008054 metal binding site [ion binding]; metal-binding site 483219008055 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 483219008056 sequence-specific DNA binding site [nucleotide binding]; other site 483219008057 salt bridge; other site 483219008058 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372 483219008059 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 483219008060 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 483219008061 ATP binding site [chemical binding]; other site 483219008062 putative Mg++ binding site [ion binding]; other site 483219008063 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 483219008064 nucleotide binding region [chemical binding]; other site 483219008065 ATP-binding site [chemical binding]; other site 483219008066 Protein of unknown function, DUF606; Region: DUF606; pfam04657 483219008067 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219008068 active site 483219008069 phosphorylation site [posttranslational modification] 483219008070 intermolecular recognition site; other site 483219008071 putative hydrolase; Provisional; Region: PRK10985 483219008072 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 483219008073 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 483219008074 Flagellin N-methylase; Region: FliB; pfam03692 483219008075 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 483219008076 Protein of unknown function, DUF481; Region: DUF481; pfam04338 483219008077 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 483219008078 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 483219008079 Subunit I/III interface [polypeptide binding]; other site 483219008080 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 483219008081 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 483219008082 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 483219008083 Cytochrome c; Region: Cytochrom_C; pfam00034 483219008084 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 483219008085 Cu(I) binding site [ion binding]; other site 483219008086 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 483219008087 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 483219008088 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 483219008089 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 483219008090 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 483219008091 molybdopterin cofactor binding site; other site 483219008092 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 483219008093 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 483219008094 4Fe-4S binding domain; Region: Fer4_2; pfam12797 483219008095 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 483219008096 heme-binding residues [chemical binding]; other site 483219008097 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 483219008098 heme-binding residues [chemical binding]; other site 483219008099 HNH endonuclease; Region: HNH; pfam01844 483219008100 active site 483219008101 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 483219008102 putative active site [active] 483219008103 putative metal binding site [ion binding]; other site 483219008104 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 483219008105 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 483219008106 ATP binding site [chemical binding]; other site 483219008107 putative Mg++ binding site [ion binding]; other site 483219008108 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 483219008109 nucleotide binding region [chemical binding]; other site 483219008110 ATP-binding site [chemical binding]; other site 483219008111 DEAD/H associated; Region: DEAD_assoc; pfam08494 483219008112 ATP-dependent DNA ligase; Validated; Region: PRK09247 483219008113 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 483219008114 active site 483219008115 DNA binding site [nucleotide binding] 483219008116 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 483219008117 DNA binding site [nucleotide binding] 483219008118 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 483219008119 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 483219008120 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 483219008121 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 483219008122 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 483219008123 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 483219008124 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 483219008125 glutamine binding [chemical binding]; other site 483219008126 catalytic triad [active] 483219008127 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 483219008128 catalytic core [active] 483219008129 CARDB; Region: CARDB; pfam07705 483219008130 CARDB; Region: CARDB; pfam07705 483219008131 CARDB; Region: CARDB; pfam07705 483219008132 CARDB; Region: CARDB; pfam07705 483219008133 CARDB; Region: CARDB; pfam07705 483219008134 CARDB; Region: CARDB; pfam07705 483219008135 Uncharacterized conserved protein [Function unknown]; Region: COG1572 483219008136 CARDB; Region: CARDB; pfam07705 483219008137 CARDB; Region: CARDB; pfam07705 483219008138 CARDB; Region: CARDB; pfam07705 483219008139 CARDB; Region: CARDB; pfam07705 483219008140 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 483219008141 substrate binding site [chemical binding]; other site 483219008142 active site 483219008143 catalytic residues [active] 483219008144 heterodimer interface [polypeptide binding]; other site 483219008145 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 483219008146 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 483219008147 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483219008148 catalytic residue [active] 483219008149 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 483219008150 active site 483219008151 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 483219008152 active site 483219008153 ribulose/triose binding site [chemical binding]; other site 483219008154 phosphate binding site [ion binding]; other site 483219008155 substrate (anthranilate) binding pocket [chemical binding]; other site 483219008156 product (indole) binding pocket [chemical binding]; other site 483219008157 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 483219008158 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 483219008159 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 483219008160 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 483219008161 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 483219008162 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 483219008163 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 483219008164 RNA polymerase factor sigma-70; Validated; Region: PRK08241 483219008165 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 483219008166 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 483219008167 DNA binding residues [nucleotide binding] 483219008168 SnoaL-like domain; Region: SnoaL_2; pfam12680 483219008169 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 483219008170 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 483219008171 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 483219008172 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 483219008173 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 483219008174 LysR family transcriptional regulator; Provisional; Region: PRK14997 483219008175 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 483219008176 putative effector binding pocket; other site 483219008177 dimerization interface [polypeptide binding]; other site 483219008178 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 483219008179 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 483219008180 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 483219008181 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 483219008182 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 483219008183 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 483219008184 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 483219008185 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 483219008186 catalytic loop [active] 483219008187 iron binding site [ion binding]; other site 483219008188 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 483219008189 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219008190 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219008191 dimer interface [polypeptide binding]; other site 483219008192 phosphorylation site [posttranslational modification] 483219008193 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219008194 ATP binding site [chemical binding]; other site 483219008195 Mg2+ binding site [ion binding]; other site 483219008196 G-X-G motif; other site 483219008197 heat shock protein 90; Provisional; Region: PRK05218 483219008198 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219008199 ATP binding site [chemical binding]; other site 483219008200 Mg2+ binding site [ion binding]; other site 483219008201 G-X-G motif; other site 483219008202 Putative phosphatase regulatory subunit; Region: CBM_21; pfam03370 483219008203 Putative phosphatase regulatory subunit; Region: CBM_21; pfam03370 483219008204 Nudix hydrolase homolog; Region: PLN02791 483219008205 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 483219008206 Fatty acid desaturase; Region: FA_desaturase; pfam00487 483219008207 putative di-iron ligands [ion binding]; other site 483219008208 TMAO/DMSO reductase; Reviewed; Region: PRK05363 483219008209 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 483219008210 Moco binding site; other site 483219008211 metal coordination site [ion binding]; other site 483219008212 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 483219008213 Response regulator receiver domain; Region: Response_reg; pfam00072 483219008214 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219008215 active site 483219008216 phosphorylation site [posttranslational modification] 483219008217 intermolecular recognition site; other site 483219008218 dimerization interface [polypeptide binding]; other site 483219008219 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219008220 TPR repeat; Region: TPR_11; pfam13414 483219008221 binding surface 483219008222 TPR motif; other site 483219008223 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 483219008224 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 483219008225 N-terminal plug; other site 483219008226 ligand-binding site [chemical binding]; other site 483219008227 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219008228 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219008229 active site 483219008230 ATP binding site [chemical binding]; other site 483219008231 substrate binding site [chemical binding]; other site 483219008232 activation loop (A-loop); other site 483219008233 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 483219008234 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 483219008235 cobalamin binding residues [chemical binding]; other site 483219008236 putative BtuC binding residues; other site 483219008237 dimer interface [polypeptide binding]; other site 483219008238 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 483219008239 Endonuclease I; Region: Endonuclease_1; pfam04231 483219008240 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 483219008241 Surface antigen; Region: Bac_surface_Ag; pfam01103 483219008242 Surface antigen; Region: Bac_surface_Ag; pfam01103 483219008243 UPF0489 domain; Region: UPF0489; pfam12640 483219008244 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 483219008245 Dienelactone hydrolase family; Region: DLH; pfam01738 483219008246 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 483219008247 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 483219008248 DNA-binding site [nucleotide binding]; DNA binding site 483219008249 RNA-binding motif; other site 483219008250 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 483219008251 e3 binding domain; Region: E3_binding; pfam02817 483219008252 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 483219008253 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 483219008254 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 483219008255 E3 interaction surface; other site 483219008256 lipoyl attachment site [posttranslational modification]; other site 483219008257 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 483219008258 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 483219008259 TPP-binding site [chemical binding]; other site 483219008260 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 483219008261 dimer interface [polypeptide binding]; other site 483219008262 PYR/PP interface [polypeptide binding]; other site 483219008263 TPP binding site [chemical binding]; other site 483219008264 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 483219008265 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 483219008266 NAD(P) binding site [chemical binding]; other site 483219008267 active site 483219008268 Response regulator receiver domain; Region: Response_reg; pfam00072 483219008269 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219008270 active site 483219008271 phosphorylation site [posttranslational modification] 483219008272 intermolecular recognition site; other site 483219008273 dimerization interface [polypeptide binding]; other site 483219008274 Response regulator receiver domain; Region: Response_reg; pfam00072 483219008275 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219008276 active site 483219008277 phosphorylation site [posttranslational modification] 483219008278 intermolecular recognition site; other site 483219008279 dimerization interface [polypeptide binding]; other site 483219008280 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 483219008281 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219008282 S-adenosylmethionine binding site [chemical binding]; other site 483219008283 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 483219008284 putative binding surface; other site 483219008285 active site 483219008286 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219008287 ATP binding site [chemical binding]; other site 483219008288 Mg2+ binding site [ion binding]; other site 483219008289 G-X-G motif; other site 483219008290 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 483219008291 Response regulator receiver domain; Region: Response_reg; pfam00072 483219008292 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219008293 active site 483219008294 phosphorylation site [posttranslational modification] 483219008295 intermolecular recognition site; other site 483219008296 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 483219008297 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219008298 active site 483219008299 phosphorylation site [posttranslational modification] 483219008300 intermolecular recognition site; other site 483219008301 dimerization interface [polypeptide binding]; other site 483219008302 CheB methylesterase; Region: CheB_methylest; pfam01339 483219008303 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219008304 dimerization interface [polypeptide binding]; other site 483219008305 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 483219008306 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 483219008307 dimer interface [polypeptide binding]; other site 483219008308 putative CheW interface [polypeptide binding]; other site 483219008309 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 483219008310 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219008311 Walker A motif; other site 483219008312 ATP binding site [chemical binding]; other site 483219008313 Walker B motif; other site 483219008314 arginine finger; other site 483219008315 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219008316 Walker A motif; other site 483219008317 ATP binding site [chemical binding]; other site 483219008318 Walker B motif; other site 483219008319 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 483219008320 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 483219008321 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 483219008322 Protein of unknown function, DUF482; Region: DUF482; pfam04339 483219008323 Protein of unknown function (DUF2378); Region: DUF2378; pfam09536 483219008324 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 483219008325 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 483219008326 Methyltransferase domain; Region: Methyltransf_32; pfam13679 483219008327 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 483219008328 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 483219008329 active site 483219008330 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 483219008331 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 483219008332 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 483219008333 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 483219008334 putative acyl-acceptor binding pocket; other site 483219008335 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 483219008336 FAD binding pocket [chemical binding]; other site 483219008337 FAD binding motif [chemical binding]; other site 483219008338 phosphate binding motif [ion binding]; other site 483219008339 beta-alpha-beta structure motif; other site 483219008340 NAD(p) ribose binding residues [chemical binding]; other site 483219008341 NAD binding pocket [chemical binding]; other site 483219008342 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 483219008343 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 483219008344 GAF domain; Region: GAF_2; pfam13185 483219008345 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219008346 dimer interface [polypeptide binding]; other site 483219008347 phosphorylation site [posttranslational modification] 483219008348 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219008349 ATP binding site [chemical binding]; other site 483219008350 Mg2+ binding site [ion binding]; other site 483219008351 G-X-G motif; other site 483219008352 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 483219008353 HSP70 interaction site [polypeptide binding]; other site 483219008354 Myxococcus xanthus paralogous domain TIGR02266; Region: gmx_TIGR02266 483219008355 Response regulator receiver domain; Region: Response_reg; pfam00072 483219008356 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219008357 active site 483219008358 phosphorylation site [posttranslational modification] 483219008359 intermolecular recognition site; other site 483219008360 dimerization interface [polypeptide binding]; other site 483219008361 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 483219008362 hypothetical protein; Provisional; Region: PRK07907 483219008363 active site 483219008364 metal binding site [ion binding]; metal-binding site 483219008365 dimer interface [polypeptide binding]; other site 483219008366 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 483219008367 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 483219008368 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 483219008369 TAP-like protein; Region: Abhydrolase_4; pfam08386 483219008370 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219008371 S-adenosylmethionine binding site [chemical binding]; other site 483219008372 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 483219008373 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219008374 Walker A/P-loop; other site 483219008375 ATP binding site [chemical binding]; other site 483219008376 Q-loop/lid; other site 483219008377 ABC transporter signature motif; other site 483219008378 Walker B; other site 483219008379 D-loop; other site 483219008380 H-loop/switch region; other site 483219008381 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 483219008382 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 483219008383 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 483219008384 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 483219008385 Kelch domain; Region: Kelch; smart00612 483219008386 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 483219008387 Kelch domain; Region: Kelch; smart00612 483219008388 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 483219008389 Kelch motif; Region: Kelch_1; pfam01344 483219008390 Galactose oxidase, central domain; Region: Kelch_3; cl02701 483219008391 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 483219008392 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 483219008393 Kelch motif; Region: Kelch_6; pfam13964 483219008394 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 483219008395 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 483219008396 Galactose oxidase, central domain; Region: Kelch_3; cl02701 483219008397 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 483219008398 Kelch domain; Region: Kelch; smart00612 483219008399 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 483219008400 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 483219008401 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219008402 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219008403 dimer interface [polypeptide binding]; other site 483219008404 phosphorylation site [posttranslational modification] 483219008405 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 483219008406 ATP binding site [chemical binding]; other site 483219008407 Mg2+ binding site [ion binding]; other site 483219008408 G-X-G motif; other site 483219008409 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 483219008410 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219008411 active site 483219008412 phosphorylation site [posttranslational modification] 483219008413 intermolecular recognition site; other site 483219008414 dimerization interface [polypeptide binding]; other site 483219008415 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 483219008416 DNA binding site [nucleotide binding] 483219008417 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 483219008418 homotrimer interaction site [polypeptide binding]; other site 483219008419 putative active site [active] 483219008420 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 483219008421 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 483219008422 G1 box; other site 483219008423 putative GEF interaction site [polypeptide binding]; other site 483219008424 GTP/Mg2+ binding site [chemical binding]; other site 483219008425 Switch I region; other site 483219008426 G2 box; other site 483219008427 G3 box; other site 483219008428 Switch II region; other site 483219008429 G4 box; other site 483219008430 G5 box; other site 483219008431 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 483219008432 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219008433 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219008434 dimer interface [polypeptide binding]; other site 483219008435 phosphorylation site [posttranslational modification] 483219008436 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219008437 ATP binding site [chemical binding]; other site 483219008438 Mg2+ binding site [ion binding]; other site 483219008439 G-X-G motif; other site 483219008440 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 483219008441 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 483219008442 active site 483219008443 Zn binding site [ion binding]; other site 483219008444 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 483219008445 dimerization interface [polypeptide binding]; other site 483219008446 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 483219008447 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219008448 S-adenosylmethionine binding site [chemical binding]; other site 483219008449 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 483219008450 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 483219008451 catalytic site [active] 483219008452 putative active site [active] 483219008453 putative substrate binding site [chemical binding]; other site 483219008454 HRDC domain; Region: HRDC; pfam00570 483219008455 HRDC domain; Region: HRDC; pfam00570 483219008456 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 483219008457 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 483219008458 Ligand Binding Site [chemical binding]; other site 483219008459 tellurite resistance protein terB; Region: terB; cd07176 483219008460 putative metal binding site [ion binding]; other site 483219008461 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 483219008462 Uncharacterized conserved protein [Function unknown]; Region: COG3791 483219008463 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219008464 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219008465 active site 483219008466 ATP binding site [chemical binding]; other site 483219008467 substrate binding site [chemical binding]; other site 483219008468 activation loop (A-loop); other site 483219008469 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 483219008470 DNA helicase, putative; Region: TIGR00376 483219008471 AAA domain; Region: AAA_30; pfam13604 483219008472 AAA domain; Region: AAA_12; pfam13087 483219008473 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 483219008474 ATP binding site [chemical binding]; other site 483219008475 Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842 483219008476 active site 483219008477 catalytic triad [active] 483219008478 AAA domain; Region: AAA_33; pfam13671 483219008479 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 483219008480 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 483219008481 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 483219008482 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 483219008483 Active site serine [active] 483219008484 H+ Antiporter protein; Region: 2A0121; TIGR00900 483219008485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483219008486 SnoaL-like domain; Region: SnoaL_4; cl17707 483219008487 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 483219008488 active site 483219008489 Fatty acid desaturase; Region: FA_desaturase; pfam00487 483219008490 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 483219008491 putative di-iron ligands [ion binding]; other site 483219008492 Protein of unknown function (DUF3419); Region: DUF3419; cl15422 483219008493 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 483219008494 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 483219008495 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 483219008496 catalytic residues [active] 483219008497 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 483219008498 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 483219008499 putative acetyltransferase; Provisional; Region: PRK03624 483219008500 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 483219008501 Coenzyme A binding pocket [chemical binding]; other site 483219008502 ATP-grasp domain; Region: ATP-grasp_4; cl17255 483219008503 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 483219008504 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 483219008505 Zn2+ binding site [ion binding]; other site 483219008506 Mg2+ binding site [ion binding]; other site 483219008507 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 483219008508 Cytochrome c; Region: Cytochrom_C; pfam00034 483219008509 Iron permease FTR1 family; Region: FTR1; cl00475 483219008510 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 483219008511 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 483219008512 folate binding site [chemical binding]; other site 483219008513 NADP+ binding site [chemical binding]; other site 483219008514 thymidylate synthase; Reviewed; Region: thyA; PRK01827 483219008515 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 483219008516 dimerization interface [polypeptide binding]; other site 483219008517 active site 483219008518 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 483219008519 epoxyqueuosine reductase; Region: TIGR00276 483219008520 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 483219008521 EamA-like transporter family; Region: EamA; pfam00892 483219008522 EamA-like transporter family; Region: EamA; pfam00892 483219008523 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3826 483219008524 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 483219008525 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 483219008526 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 483219008527 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 483219008528 Peptidase family M48; Region: Peptidase_M48; pfam01435 483219008529 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 483219008530 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 483219008531 DNA binding site [nucleotide binding] 483219008532 catalytic residue [active] 483219008533 H2TH interface [polypeptide binding]; other site 483219008534 putative catalytic residues [active] 483219008535 turnover-facilitating residue; other site 483219008536 intercalation triad [nucleotide binding]; other site 483219008537 8OG recognition residue [nucleotide binding]; other site 483219008538 putative reading head residues; other site 483219008539 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 483219008540 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 483219008541 diaminopimelate decarboxylase; Region: lysA; TIGR01048 483219008542 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 483219008543 active site 483219008544 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 483219008545 substrate binding site [chemical binding]; other site 483219008546 catalytic residues [active] 483219008547 dimer interface [polypeptide binding]; other site 483219008548 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 483219008549 dihydrodipicolinate synthase; Region: dapA; TIGR00674 483219008550 dimer interface [polypeptide binding]; other site 483219008551 active site 483219008552 catalytic residue [active] 483219008553 dihydrodipicolinate reductase; Provisional; Region: PRK00048 483219008554 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 483219008555 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 483219008556 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 483219008557 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 483219008558 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 483219008559 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 483219008560 catalytic center binding site [active] 483219008561 ATP binding site [chemical binding]; other site 483219008562 TPR repeat; Region: TPR_11; pfam13414 483219008563 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 483219008564 TPR motif; other site 483219008565 binding surface 483219008566 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219008567 binding surface 483219008568 TPR motif; other site 483219008569 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 483219008570 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 483219008571 putative active site [active] 483219008572 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 483219008573 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 483219008574 active site 483219008575 intersubunit interactions; other site 483219008576 catalytic residue [active] 483219008577 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 483219008578 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 483219008579 active site 483219008580 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 483219008581 Ligand binding site [chemical binding]; other site 483219008582 Electron transfer flavoprotein domain; Region: ETF; pfam01012 483219008583 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 483219008584 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 483219008585 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 483219008586 Cytochrome oxidase complex assembly protein 1; Region: Coa1; pfam08695 483219008587 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 483219008588 Coenzyme A binding pocket [chemical binding]; other site 483219008589 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 483219008590 EamA-like transporter family; Region: EamA; pfam00892 483219008591 EamA-like transporter family; Region: EamA; pfam00892 483219008592 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 483219008593 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 483219008594 MOSC domain; Region: MOSC; pfam03473 483219008595 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 483219008596 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 483219008597 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 483219008598 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 483219008599 RNA binding surface [nucleotide binding]; other site 483219008600 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 483219008601 active site 483219008602 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 483219008603 Transglycosylase; Region: Transgly; pfam00912 483219008604 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 483219008605 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 483219008606 active site 483219008607 dimer interface [polypeptide binding]; other site 483219008608 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 483219008609 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 483219008610 NAD(P) binding site [chemical binding]; other site 483219008611 active site 483219008612 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 483219008613 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 483219008614 active site 483219008615 Zn binding site [ion binding]; other site 483219008616 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219008617 dimerization interface [polypeptide binding]; other site 483219008618 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 483219008619 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 483219008620 dimer interface [polypeptide binding]; other site 483219008621 putative CheW interface [polypeptide binding]; other site 483219008622 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 483219008623 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483219008624 putative substrate translocation pore; other site 483219008625 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 483219008626 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 483219008627 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 483219008628 TrkA-N domain; Region: TrkA_N; pfam02254 483219008629 TrkA-C domain; Region: TrkA_C; pfam02080 483219008630 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 483219008631 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 483219008632 Helix-turn-helix domain; Region: HTH_18; pfam12833 483219008633 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 483219008634 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 483219008635 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 483219008636 DNA binding site [nucleotide binding] 483219008637 active site 483219008638 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 483219008639 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 483219008640 catalytic core [active] 483219008641 Phosphotransferase enzyme family; Region: APH; pfam01636 483219008642 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 483219008643 putative active site [active] 483219008644 putative substrate binding site [chemical binding]; other site 483219008645 ATP binding site [chemical binding]; other site 483219008646 short chain dehydrogenase; Provisional; Region: PRK05650 483219008647 classical (c) SDRs; Region: SDR_c; cd05233 483219008648 NAD(P) binding site [chemical binding]; other site 483219008649 active site 483219008650 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 483219008651 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 483219008652 active site 483219008653 Transcriptional regulator [Transcription]; Region: LysR; COG0583 483219008654 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 483219008655 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 483219008656 substrate binding pocket [chemical binding]; other site 483219008657 dimerization interface [polypeptide binding]; other site 483219008658 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 483219008659 DNA methylase; Region: N6_N4_Mtase; pfam01555 483219008660 Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025 483219008661 active site 483219008662 catalytic residues [active] 483219008663 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 483219008664 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 483219008665 Glutamate binding site [chemical binding]; other site 483219008666 NAD binding site [chemical binding]; other site 483219008667 catalytic residues [active] 483219008668 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 483219008669 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 483219008670 allantoinase; Region: allantoinase; TIGR03178 483219008671 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 483219008672 active site 483219008673 allantoicase; Provisional; Region: PRK13257 483219008674 Allantoicase repeat; Region: Allantoicase; pfam03561 483219008675 Allantoicase repeat; Region: Allantoicase; pfam03561 483219008676 putative OHCU decarboxylase; Provisional; Region: PRK13798 483219008677 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 483219008678 active site 483219008679 homotetramer interface [polypeptide binding]; other site 483219008680 Uncharacterized conserved protein [Function unknown]; Region: COG3189 483219008681 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 483219008682 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219008683 active site 483219008684 phosphorylation site [posttranslational modification] 483219008685 intermolecular recognition site; other site 483219008686 dimerization interface [polypeptide binding]; other site 483219008687 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 483219008688 active site 483219008689 substrate binding sites [chemical binding]; other site 483219008690 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219008691 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219008692 active site 483219008693 ATP binding site [chemical binding]; other site 483219008694 substrate binding site [chemical binding]; other site 483219008695 activation loop (A-loop); other site 483219008696 AAA ATPase domain; Region: AAA_16; pfam13191 483219008697 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 483219008698 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 483219008699 putative acyltransferase; Provisional; Region: PRK05790 483219008700 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 483219008701 dimer interface [polypeptide binding]; other site 483219008702 active site 483219008703 Eukaryotic integral membrane protein (DUF1751); Region: DUF1751; pfam08551 483219008704 Activator of aromatic catabolism; Region: XylR_N; pfam06505 483219008705 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 483219008706 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 483219008707 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219008708 Walker A motif; other site 483219008709 ATP binding site [chemical binding]; other site 483219008710 Walker B motif; other site 483219008711 arginine finger; other site 483219008712 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 483219008713 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 483219008714 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 483219008715 putative active site [active] 483219008716 metal binding site [ion binding]; metal-binding site 483219008717 Uncharacterized conserved protein [Function unknown]; Region: COG2353 483219008718 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 483219008719 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 483219008720 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 483219008721 Zn binding site [ion binding]; other site 483219008722 threonine dehydratase; Provisional; Region: PRK08198 483219008723 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 483219008724 tetramer interface [polypeptide binding]; other site 483219008725 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483219008726 catalytic residue [active] 483219008727 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 483219008728 glutamate dehydrogenase; Region: PLN02477 483219008729 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 483219008730 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 483219008731 NAD(P) binding site [chemical binding]; other site 483219008732 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 483219008733 sequence-specific DNA binding site [nucleotide binding]; other site 483219008734 salt bridge; other site 483219008735 helicase 45; Provisional; Region: PTZ00424 483219008736 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 483219008737 ATP binding site [chemical binding]; other site 483219008738 Mg++ binding site [ion binding]; other site 483219008739 motif III; other site 483219008740 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 483219008741 nucleotide binding region [chemical binding]; other site 483219008742 ATP-binding site [chemical binding]; other site 483219008743 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 483219008744 alternative sigma factor RpoH; Region: rpoH_proteo; TIGR02392 483219008745 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 483219008746 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 483219008747 DNA binding residues [nucleotide binding] 483219008748 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 483219008749 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 483219008750 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 483219008751 active site 483219008752 Farnesoic acid 0-methyl transferase; Region: Methyltransf_FA; pfam12248 483219008753 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 483219008754 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 483219008755 metal ion-dependent adhesion site (MIDAS); other site 483219008756 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 483219008757 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 483219008758 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 483219008759 E-class dimer interface [polypeptide binding]; other site 483219008760 P-class dimer interface [polypeptide binding]; other site 483219008761 active site 483219008762 Cu2+ binding site [ion binding]; other site 483219008763 Zn2+ binding site [ion binding]; other site 483219008764 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 483219008765 Methyltransferase domain; Region: Methyltransf_26; pfam13659 483219008766 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 483219008767 Ion transport protein; Region: Ion_trans; pfam00520 483219008768 Ion channel; Region: Ion_trans_2; pfam07885 483219008769 Double zinc ribbon; Region: DZR; pfam12773 483219008770 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 483219008771 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 483219008772 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 483219008773 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 483219008774 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 483219008775 NAD(P) binding site [chemical binding]; other site 483219008776 active site 483219008777 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 483219008778 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 483219008779 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 483219008780 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219008781 dimerization interface [polypeptide binding]; other site 483219008782 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_4; cd06231 483219008783 putative active site [active] 483219008784 Zn binding site [ion binding]; other site 483219008785 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 483219008786 dimer interface [polypeptide binding]; other site 483219008787 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 483219008788 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 483219008789 active site 483219008790 PHP Thumb interface [polypeptide binding]; other site 483219008791 metal binding site [ion binding]; metal-binding site 483219008792 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 483219008793 generic binding surface II; other site 483219008794 generic binding surface I; other site 483219008795 enoyl-CoA hydratase; Provisional; Region: PRK06142 483219008796 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 483219008797 substrate binding site [chemical binding]; other site 483219008798 oxyanion hole (OAH) forming residues; other site 483219008799 trimer interface [polypeptide binding]; other site 483219008800 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 483219008801 prephenate dehydrogenase; Validated; Region: PRK08507 483219008802 Chorismate mutase type II; Region: CM_2; smart00830 483219008803 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 483219008804 Peptidase family U32; Region: Peptidase_U32; pfam01136 483219008805 Collagenase; Region: DUF3656; pfam12392 483219008806 Peptidase family U32; Region: Peptidase_U32; cl03113 483219008807 short chain dehydrogenase; Provisional; Region: PRK07576 483219008808 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 483219008809 NAD(P) binding site [chemical binding]; other site 483219008810 substrate binding site [chemical binding]; other site 483219008811 homotetramer interface [polypeptide binding]; other site 483219008812 active site 483219008813 homodimer interface [polypeptide binding]; other site 483219008814 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 483219008815 Fibronectin type III domain; Region: fn3; pfam00041 483219008816 Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin; Region: M3A_TOP; cd06455 483219008817 active site 483219008818 Zn binding site [ion binding]; other site 483219008819 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 483219008820 SnoaL-like domain; Region: SnoaL_2; pfam12680 483219008821 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 483219008822 homodimer interface [polypeptide binding]; other site 483219008823 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 483219008824 active site pocket [active] 483219008825 Protein of unknown function (DUF2378); Region: DUF2378; pfam09536 483219008826 putative peptidase; Provisional; Region: PRK11649 483219008827 Peptidase family M23; Region: Peptidase_M23; pfam01551 483219008828 SpoVR like protein; Region: SpoVR; pfam04293 483219008829 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 483219008830 hypothetical protein; Provisional; Region: PRK05325 483219008831 PrkA AAA domain; Region: AAA_PrkA; smart00763 483219008832 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 483219008833 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 483219008834 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 483219008835 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219008836 TPR motif; other site 483219008837 binding surface 483219008838 Peptidase family M48; Region: Peptidase_M48; cl12018 483219008839 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 483219008840 binding surface 483219008841 TPR motif; other site 483219008842 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 483219008843 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 483219008844 P loop; other site 483219008845 Nucleotide binding site [chemical binding]; other site 483219008846 DTAP/Switch II; other site 483219008847 Switch I; other site 483219008848 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 483219008849 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 483219008850 DTAP/Switch II; other site 483219008851 Switch I; other site 483219008852 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 483219008853 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 483219008854 P-loop; other site 483219008855 Magnesium ion binding site [ion binding]; other site 483219008856 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 483219008857 Magnesium ion binding site [ion binding]; other site 483219008858 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 483219008859 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 483219008860 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 483219008861 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 483219008862 active site 483219008863 catalytic site [active] 483219008864 putative carboxyl-terminal-processing protease, deltaproteobacterial; Region: prc_long_Delta; TIGR03900 483219008865 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 483219008866 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 483219008867 protein binding site [polypeptide binding]; other site 483219008868 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 483219008869 Catalytic dyad [active] 483219008870 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 483219008871 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 483219008872 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 483219008873 nucleotide binding site [chemical binding]; other site 483219008874 putative NEF/HSP70 interaction site [polypeptide binding]; other site 483219008875 SBD interface [polypeptide binding]; other site 483219008876 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 483219008877 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 483219008878 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 483219008879 motif 1; other site 483219008880 active site 483219008881 motif 2; other site 483219008882 motif 3; other site 483219008883 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 483219008884 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 483219008885 DDE superfamily endonuclease; Region: DDE_5; pfam13546 483219008886 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 483219008887 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 483219008888 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 483219008889 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 483219008890 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 483219008891 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 483219008892 Integrase core domain; Region: rve; pfam00665 483219008893 transposase/IS protein; Provisional; Region: PRK09183 483219008894 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219008895 Walker A motif; other site 483219008896 ATP binding site [chemical binding]; other site 483219008897 Walker B motif; other site 483219008898 arginine finger; other site 483219008899 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219008900 active site 483219008901 ATP binding site [chemical binding]; other site 483219008902 substrate binding site [chemical binding]; other site 483219008903 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 483219008904 activation loop (A-loop); other site 483219008905 activation loop (A-loop); other site 483219008906 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 483219008907 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 483219008908 non-specific DNA binding site [nucleotide binding]; other site 483219008909 salt bridge; other site 483219008910 sequence-specific DNA binding site [nucleotide binding]; other site 483219008911 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 483219008912 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 483219008913 sequence-specific DNA binding site [nucleotide binding]; other site 483219008914 salt bridge; other site 483219008915 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 483219008916 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219008917 active site 483219008918 ATP binding site [chemical binding]; other site 483219008919 substrate binding site [chemical binding]; other site 483219008920 activation loop (A-loop); other site 483219008921 Protein of unknown function (DUF2381); Region: DUF2381; pfam09544 483219008922 ATP synthase (C/AC39) subunit; Region: vATP-synt_AC39; pfam01992 483219008923 Homeodomain-like domain; Region: HTH_32; pfam13565 483219008924 putative transposase OrfB; Reviewed; Region: PHA02517 483219008925 Integrase core domain; Region: rve; pfam00665 483219008926 Integrase core domain; Region: rve_3; pfam13683 483219008927 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 483219008928 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219008929 S-adenosylmethionine binding site [chemical binding]; other site 483219008930 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 483219008931 dimer interface [polypeptide binding]; other site 483219008932 catalytic triad [active] 483219008933 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 483219008934 Beta-lactamase; Region: Beta-lactamase; pfam00144 483219008935 UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773 483219008936 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 483219008937 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 483219008938 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 483219008939 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 483219008940 catalytic residues [active] 483219008941 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 483219008942 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 483219008943 active site 483219008944 dimerization interface [polypeptide binding]; other site 483219008945 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 483219008946 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 483219008947 SLBB domain; Region: SLBB; pfam10531 483219008948 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 483219008949 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 483219008950 ligand binding site [chemical binding]; other site 483219008951 flexible hinge region; other site 483219008952 Gram-negative bacterial tonB protein; Region: TonB; cl10048 483219008953 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219008954 binding surface 483219008955 TPR motif; other site 483219008956 TPR repeat; Region: TPR_11; pfam13414 483219008957 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219008958 TPR motif; other site 483219008959 binding surface 483219008960 TPR repeat; Region: TPR_11; pfam13414 483219008961 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 483219008962 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 483219008963 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219008964 binding surface 483219008965 TPR motif; other site 483219008966 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 483219008967 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219008968 binding surface 483219008969 TPR motif; other site 483219008970 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 483219008971 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 483219008972 G1 box; other site 483219008973 GTP/Mg2+ binding site [chemical binding]; other site 483219008974 G2 box; other site 483219008975 Switch I region; other site 483219008976 G3 box; other site 483219008977 Switch II region; other site 483219008978 G4 box; other site 483219008979 G5 box; other site 483219008980 Roadblock/LC7 domain; Region: Robl_LC7; pfam03259 483219008981 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 483219008982 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 483219008983 Cna protein B-type domain; Region: Cna_B_2; pfam13715 483219008984 FecR protein; Region: FecR; pfam04773 483219008985 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219008986 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219008987 active site 483219008988 ATP binding site [chemical binding]; other site 483219008989 substrate binding site [chemical binding]; other site 483219008990 activation loop (A-loop); other site 483219008991 recombination protein RecR; Reviewed; Region: recR; PRK00076 483219008992 Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278 483219008993 RecR protein; Region: RecR; pfam02132 483219008994 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 483219008995 putative active site [active] 483219008996 putative metal-binding site [ion binding]; other site 483219008997 tetramer interface [polypeptide binding]; other site 483219008998 hypothetical protein; Validated; Region: PRK00153 483219008999 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 483219009000 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 483219009001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219009002 Walker A motif; other site 483219009003 ATP binding site [chemical binding]; other site 483219009004 Walker B motif; other site 483219009005 arginine finger; other site 483219009006 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 483219009007 Alg9-like mannosyltransferase family; Region: Glyco_transf_22; cl17751 483219009008 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 483219009009 nucleoside/Zn binding site; other site 483219009010 dimer interface [polypeptide binding]; other site 483219009011 catalytic motif [active] 483219009012 seryl-tRNA synthetase; Provisional; Region: PRK05431 483219009013 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 483219009014 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 483219009015 dimer interface [polypeptide binding]; other site 483219009016 active site 483219009017 motif 1; other site 483219009018 motif 2; other site 483219009019 motif 3; other site 483219009020 zinc-ribbon domain; Region: zinc_ribbon_4; pfam13717 483219009021 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 483219009022 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219009023 TPR motif; other site 483219009024 binding surface 483219009025 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219009026 binding surface 483219009027 TPR motif; other site 483219009028 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219009029 TPR motif; other site 483219009030 binding surface 483219009031 TPR repeat; Region: TPR_11; pfam13414 483219009032 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219009033 binding surface 483219009034 TPR motif; other site 483219009035 TPR repeat; Region: TPR_11; pfam13414 483219009036 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219009037 TPR motif; other site 483219009038 binding surface 483219009039 TPR repeat; Region: TPR_11; pfam13414 483219009040 hypothetical protein; Provisional; Region: PRK07208 483219009041 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 483219009042 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 483219009043 Ligand binding site; other site 483219009044 Putative Catalytic site; other site 483219009045 DXD motif; other site 483219009046 Putative catalytic domain of uncharacterized bacterial polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_1; cd10940 483219009047 putative active site [active] 483219009048 putative catalytic site [active] 483219009049 putative Zn binding site [ion binding]; other site 483219009050 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 483219009051 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 483219009052 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 483219009053 putative acyl-acceptor binding pocket; other site 483219009054 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 483219009055 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 483219009056 putative NAD(P) binding site [chemical binding]; other site 483219009057 active site 483219009058 putative substrate binding site [chemical binding]; other site 483219009059 TPR repeat; Region: TPR_11; pfam13414 483219009060 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219009061 binding surface 483219009062 TPR motif; other site 483219009063 Tetratricopeptide repeat; Region: TPR_16; pfam13432 483219009064 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219009065 TPR repeat; Region: TPR_11; pfam13414 483219009066 binding surface 483219009067 TPR motif; other site 483219009068 heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540 483219009069 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219009070 binding surface 483219009071 TPR motif; other site 483219009072 Tetratricopeptide repeat; Region: TPR_16; pfam13432 483219009073 DEAD-like helicases superfamily; Region: DEXDc; smart00487 483219009074 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 483219009075 ATP binding site [chemical binding]; other site 483219009076 putative Mg++ binding site [ion binding]; other site 483219009077 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 483219009078 nucleotide binding region [chemical binding]; other site 483219009079 ATP-binding site [chemical binding]; other site 483219009080 HRDC domain; Region: HRDC; pfam00570 483219009081 hypothetical protein; Reviewed; Region: PRK00024 483219009082 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 483219009083 MPN+ (JAMM) motif; other site 483219009084 Zinc-binding site [ion binding]; other site 483219009085 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 483219009086 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 483219009087 ligand binding site [chemical binding]; other site 483219009088 flexible hinge region; other site 483219009089 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 483219009090 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 483219009091 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 483219009092 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 483219009093 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 483219009094 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 483219009095 catalytic residue [active] 483219009096 molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364 483219009097 trimer interface [polypeptide binding]; other site 483219009098 dimer interface [polypeptide binding]; other site 483219009099 putative active site [active] 483219009100 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 483219009101 dimer interface [polypeptide binding]; other site 483219009102 ADP-ribose binding site [chemical binding]; other site 483219009103 active site 483219009104 nudix motif; other site 483219009105 metal binding site [ion binding]; metal-binding site 483219009106 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 483219009107 Tetratricopeptide repeat; Region: TPR_9; pfam13371 483219009108 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 483219009109 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 483219009110 CoA binding domain; Region: CoA_binding; cl17356 483219009111 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 483219009112 putative active site [active] 483219009113 putative catalytic triad [active] 483219009114 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 483219009115 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 483219009116 active site 483219009117 nucleophile elbow; other site 483219009118 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 483219009119 dimerization interface [polypeptide binding]; other site 483219009120 putative DNA binding site [nucleotide binding]; other site 483219009121 putative Zn2+ binding site [ion binding]; other site 483219009122 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219009123 S-adenosylmethionine binding site [chemical binding]; other site 483219009124 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 483219009125 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 483219009126 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 483219009127 substrate binding pocket [chemical binding]; other site 483219009128 dimer interface [polypeptide binding]; other site 483219009129 inhibitor binding site; inhibition site 483219009130 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 483219009131 B12 binding site [chemical binding]; other site 483219009132 cobalt ligand [ion binding]; other site 483219009133 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 483219009134 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 483219009135 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 483219009136 FRG domain; Region: FRG; pfam08867 483219009137 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 483219009138 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 483219009139 minor groove reading motif; other site 483219009140 helix-hairpin-helix signature motif; other site 483219009141 substrate binding pocket [chemical binding]; other site 483219009142 active site 483219009143 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 483219009144 DNA binding and oxoG recognition site [nucleotide binding] 483219009145 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 483219009146 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 483219009147 NADP binding site [chemical binding]; other site 483219009148 active site 483219009149 steroid binding site; other site 483219009150 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 483219009151 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 483219009152 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 483219009153 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 483219009154 putative ATP binding site [chemical binding]; other site 483219009155 putative substrate interface [chemical binding]; other site 483219009156 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 483219009157 active site 483219009158 Cupin domain; Region: Cupin_2; cl17218 483219009159 Maf-like protein; Region: Maf; pfam02545 483219009160 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 483219009161 active site 483219009162 dimer interface [polypeptide binding]; other site 483219009163 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 483219009164 binding surface 483219009165 TPR motif; other site 483219009166 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 483219009167 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 483219009168 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 483219009169 putative RNA binding site [nucleotide binding]; other site 483219009170 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219009171 S-adenosylmethionine binding site [chemical binding]; other site 483219009172 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 483219009173 Part of AAA domain; Region: AAA_19; pfam13245 483219009174 Family description; Region: UvrD_C_2; pfam13538 483219009175 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 483219009176 23S rRNA interface [nucleotide binding]; other site 483219009177 L3 interface [polypeptide binding]; other site 483219009178 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 483219009179 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 483219009180 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 483219009181 ATP binding site [chemical binding]; other site 483219009182 Walker B motif; other site 483219009183 recombination regulator RecX; Reviewed; Region: recX; PRK00117 483219009184 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 483219009185 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219009186 binding surface 483219009187 TPR repeat; Region: TPR_11; pfam13414 483219009188 TPR motif; other site 483219009189 Tetratricopeptide repeat; Region: TPR_16; pfam13432 483219009190 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219009191 binding surface 483219009192 TPR motif; other site 483219009193 TPR repeat; Region: TPR_11; pfam13414 483219009194 Tetratricopeptide repeat; Region: TPR_16; pfam13432 483219009195 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 483219009196 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 483219009197 phosphopeptide binding site; other site 483219009198 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 483219009199 selenophosphate synthetase; Provisional; Region: PRK00943 483219009200 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 483219009201 dimerization interface [polypeptide binding]; other site 483219009202 putative ATP binding site [chemical binding]; other site 483219009203 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 483219009204 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 483219009205 active site 483219009206 metal binding site [ion binding]; metal-binding site 483219009207 ribonuclease PH; Reviewed; Region: rph; PRK00173 483219009208 Ribonuclease PH; Region: RNase_PH_bact; cd11362 483219009209 hexamer interface [polypeptide binding]; other site 483219009210 active site 483219009211 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 483219009212 active site 483219009213 dimerization interface [polypeptide binding]; other site 483219009214 RecT family; Region: RecT; pfam03837 483219009215 trigger factor; Region: tig; TIGR00115 483219009216 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 483219009217 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 483219009218 Clp protease; Region: CLP_protease; pfam00574 483219009219 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 483219009220 oligomer interface [polypeptide binding]; other site 483219009221 active site residues [active] 483219009222 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 483219009223 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 483219009224 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219009225 Walker A motif; other site 483219009226 ATP binding site [chemical binding]; other site 483219009227 Walker B motif; other site 483219009228 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 483219009229 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 483219009230 Protein of unknown function (DUF3979); Region: DUF3979; pfam13141 483219009231 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 483219009232 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 483219009233 Found in ATP-dependent protease La (LON); Region: LON; smart00464 483219009234 Found in ATP-dependent protease La (LON); Region: LON; smart00464 483219009235 Mediator complex protein; Region: Med11; pfam10280 483219009236 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219009237 Walker A motif; other site 483219009238 ATP binding site [chemical binding]; other site 483219009239 Walker B motif; other site 483219009240 arginine finger; other site 483219009241 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 483219009242 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 483219009243 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 483219009244 peptide binding site [polypeptide binding]; other site 483219009245 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 483219009246 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483219009247 dimer interface [polypeptide binding]; other site 483219009248 conserved gate region; other site 483219009249 putative PBP binding loops; other site 483219009250 ABC-ATPase subunit interface; other site 483219009251 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483219009252 dimer interface [polypeptide binding]; other site 483219009253 conserved gate region; other site 483219009254 putative PBP binding loops; other site 483219009255 ABC-ATPase subunit interface; other site 483219009256 Response regulator receiver domain; Region: Response_reg; pfam00072 483219009257 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219009258 active site 483219009259 phosphorylation site [posttranslational modification] 483219009260 intermolecular recognition site; other site 483219009261 dimerization interface [polypeptide binding]; other site 483219009262 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 483219009263 BolA-like protein; Region: BolA; pfam01722 483219009264 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 483219009265 putative GSH binding site [chemical binding]; other site 483219009266 catalytic residues [active] 483219009267 Protein of unknown function (DUF2914); Region: DUF2914; pfam11141 483219009268 proline aminopeptidase P II; Provisional; Region: PRK10879 483219009269 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 483219009270 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 483219009271 active site 483219009272 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 483219009273 RNA methyltransferase, RsmE family; Region: TIGR00046 483219009274 DTW domain; Region: DTW; cl01221 483219009275 FecR protein; Region: FecR; pfam04773 483219009276 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 483219009277 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 483219009278 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 483219009279 DNA binding residues [nucleotide binding] 483219009280 Methyltransferase domain; Region: Methyltransf_26; pfam13659 483219009281 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 483219009282 Fe-S cluster binding site [ion binding]; other site 483219009283 active site 483219009284 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 483219009285 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 483219009286 substrate binding site [chemical binding]; other site 483219009287 oxyanion hole (OAH) forming residues; other site 483219009288 trimer interface [polypeptide binding]; other site 483219009289 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 483219009290 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 483219009291 homodimer interface [polypeptide binding]; other site 483219009292 substrate-cofactor binding pocket; other site 483219009293 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483219009294 catalytic residue [active] 483219009295 Protein of unknown function (DUF687); Region: DUF687; pfam05095 483219009296 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 483219009297 putative active site [active] 483219009298 putative catalytic site [active] 483219009299 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 483219009300 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 483219009301 dimer interface [polypeptide binding]; other site 483219009302 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483219009303 catalytic residue [active] 483219009304 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 483219009305 Phosphotransferase enzyme family; Region: APH; pfam01636 483219009306 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 483219009307 substrate binding site [chemical binding]; other site 483219009308 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 483219009309 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 483219009310 Substrate binding site; other site 483219009311 metal-binding site 483219009312 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 483219009313 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 483219009314 active site 483219009315 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 483219009316 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 483219009317 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 483219009318 HSP70 interaction site [polypeptide binding]; other site 483219009319 TPR repeat; Region: TPR_11; pfam13414 483219009320 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219009321 binding surface 483219009322 TPR motif; other site 483219009323 Response regulator receiver domain; Region: Response_reg; pfam00072 483219009324 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219009325 active site 483219009326 phosphorylation site [posttranslational modification] 483219009327 intermolecular recognition site; other site 483219009328 dimerization interface [polypeptide binding]; other site 483219009329 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 483219009330 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219009331 binding surface 483219009332 Tetratricopeptide repeat; Region: TPR_16; pfam13432 483219009333 TPR motif; other site 483219009334 Tetratricopeptide repeat; Region: TPR_16; pfam13432 483219009335 UGMP family protein; Validated; Region: PRK09604 483219009336 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 483219009337 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 483219009338 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219009339 S-adenosylmethionine binding site [chemical binding]; other site 483219009340 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 483219009341 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 483219009342 Substrate-binding site [chemical binding]; other site 483219009343 Substrate specificity [chemical binding]; other site 483219009344 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 483219009345 oligomerization interface [polypeptide binding]; other site 483219009346 active site 483219009347 metal binding site [ion binding]; metal-binding site 483219009348 Pantoate-beta-alanine ligase; Region: PanC; cd00560 483219009349 pantoate--beta-alanine ligase; Region: panC; TIGR00018 483219009350 active site 483219009351 ATP-binding site [chemical binding]; other site 483219009352 pantoate-binding site; other site 483219009353 HXXH motif; other site 483219009354 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 483219009355 SmpB-tmRNA interface; other site 483219009356 Stringent starvation protein B; Region: SspB; cl01120 483219009357 Protein kinase; unclassified specificity; Region: STYKc; smart00221 483219009358 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219009359 active site 483219009360 ATP binding site [chemical binding]; other site 483219009361 substrate binding site [chemical binding]; other site 483219009362 activation loop (A-loop); other site 483219009363 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 483219009364 PEGA domain; Region: PEGA; pfam08308 483219009365 Protein of unknown function (DUF971); Region: DUF971; pfam06155 483219009366 Cache domain; Region: Cache_1; pfam02743 483219009367 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219009368 dimerization interface [polypeptide binding]; other site 483219009369 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 483219009370 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 483219009371 Zn2+ binding site [ion binding]; other site 483219009372 Mg2+ binding site [ion binding]; other site 483219009373 LysM domain; Region: LysM; pfam01476 483219009374 FecR protein; Region: FecR; pfam04773 483219009375 nitrilase; Region: PLN02798 483219009376 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 483219009377 putative active site [active] 483219009378 catalytic triad [active] 483219009379 dimer interface [polypeptide binding]; other site 483219009380 ribosome maturation protein RimP; Reviewed; Region: PRK00092 483219009381 Sm and related proteins; Region: Sm_like; cl00259 483219009382 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 483219009383 putative oligomer interface [polypeptide binding]; other site 483219009384 putative RNA binding site [nucleotide binding]; other site 483219009385 NusA N-terminal domain; Region: NusA_N; pfam08529 483219009386 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 483219009387 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 483219009388 RNA binding site [nucleotide binding]; other site 483219009389 homodimer interface [polypeptide binding]; other site 483219009390 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 483219009391 G-X-X-G motif; other site 483219009392 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 483219009393 G-X-X-G motif; other site 483219009394 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 483219009395 putative RNA binding cleft [nucleotide binding]; other site 483219009396 translation initiation factor IF-2; Region: IF-2; TIGR00487 483219009397 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 483219009398 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 483219009399 G1 box; other site 483219009400 putative GEF interaction site [polypeptide binding]; other site 483219009401 GTP/Mg2+ binding site [chemical binding]; other site 483219009402 Switch I region; other site 483219009403 G2 box; other site 483219009404 G3 box; other site 483219009405 Switch II region; other site 483219009406 G4 box; other site 483219009407 G5 box; other site 483219009408 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 483219009409 Translation-initiation factor 2; Region: IF-2; pfam11987 483219009410 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 483219009411 Protein of unknown function (DUF503); Region: DUF503; pfam04456 483219009412 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 483219009413 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 483219009414 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 483219009415 RNA binding site [nucleotide binding]; other site 483219009416 active site 483219009417 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 483219009418 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 483219009419 16S/18S rRNA binding site [nucleotide binding]; other site 483219009420 S13e-L30e interaction site [polypeptide binding]; other site 483219009421 25S rRNA binding site [nucleotide binding]; other site 483219009422 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 483219009423 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 483219009424 RNase E interface [polypeptide binding]; other site 483219009425 trimer interface [polypeptide binding]; other site 483219009426 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 483219009427 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 483219009428 RNase E interface [polypeptide binding]; other site 483219009429 trimer interface [polypeptide binding]; other site 483219009430 active site 483219009431 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 483219009432 putative nucleic acid binding region [nucleotide binding]; other site 483219009433 G-X-X-G motif; other site 483219009434 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 483219009435 RNA binding site [nucleotide binding]; other site 483219009436 domain interface; other site 483219009437 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 483219009438 Peptidase family M23; Region: Peptidase_M23; pfam01551 483219009439 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 483219009440 trimer interface [polypeptide binding]; other site 483219009441 active site 483219009442 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219009443 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219009444 active site 483219009445 ATP binding site [chemical binding]; other site 483219009446 substrate binding site [chemical binding]; other site 483219009447 activation loop (A-loop); other site 483219009448 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 483219009449 Uncharacterized conserved protein [Function unknown]; Region: COG1262 483219009450 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 483219009451 adenylosuccinate lyase; Provisional; Region: PRK07492 483219009452 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 483219009453 tetramer interface [polypeptide binding]; other site 483219009454 active site 483219009455 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 483219009456 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 483219009457 ATP binding site [chemical binding]; other site 483219009458 active site 483219009459 substrate binding site [chemical binding]; other site 483219009460 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 483219009461 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 483219009462 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 483219009463 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 483219009464 protein binding site [polypeptide binding]; other site 483219009465 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 483219009466 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 483219009467 catalytic residues [active] 483219009468 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 483219009469 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 483219009470 ligand binding site [chemical binding]; other site 483219009471 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 483219009472 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 483219009473 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 483219009474 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 483219009475 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 483219009476 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 483219009477 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 483219009478 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 483219009479 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 483219009480 active site 483219009481 Int/Topo IB signature motif; other site 483219009482 DNA binding site [nucleotide binding] 483219009483 Phage major tail protein 2; Region: Phage_tail_2; cl11463 483219009484 Phage capsid family; Region: Phage_capsid; pfam05065 483219009485 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 483219009486 Phage-related protein [Function unknown]; Region: COG4695; cl01923 483219009487 Fic/DOC family; Region: Fic; pfam02661 483219009488 ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]; Region: RPT1; COG1222 483219009489 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 483219009490 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 483219009491 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 483219009492 Phage-related protein [Function unknown]; Region: COG4695; cl01923 483219009493 Uncharacterized conserved protein [Function unknown]; Region: COG5323 483219009494 Terminase-like family; Region: Terminase_6; pfam03237 483219009495 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 483219009496 NlpC/P60 family; Region: NLPC_P60; cl17555 483219009497 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 483219009498 DNA methylase; Region: N6_N4_Mtase; pfam01555 483219009499 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 483219009500 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 483219009501 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 483219009502 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 483219009503 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 483219009504 putative homodimer interface [polypeptide binding]; other site 483219009505 putative active site [active] 483219009506 catalytic site [active] 483219009507 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 483219009508 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 483219009509 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 483219009510 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219009511 S-adenosylmethionine binding site [chemical binding]; other site 483219009512 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 483219009513 conserved cys residue [active] 483219009514 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 483219009515 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 483219009516 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 483219009517 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219009518 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219009519 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219009520 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 483219009521 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219009522 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219009523 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219009524 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219009525 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 483219009526 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219009527 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219009528 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219009529 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 483219009530 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219009531 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219009532 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 483219009533 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219009534 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219009535 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219009536 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 483219009537 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219009538 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219009539 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219009540 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 483219009541 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219009542 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219009543 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219009544 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219009545 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219009546 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219009547 Methyltransferase domain; Region: Methyltransf_32; pfam13679 483219009548 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 483219009549 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 483219009550 calcium binding site 2 [ion binding]; other site 483219009551 active site 483219009552 catalytic triad [active] 483219009553 calcium binding site 1 [ion binding]; other site 483219009554 Family description; Region: VCBS; pfam13517 483219009555 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 483219009556 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 483219009557 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483219009558 homodimer interface [polypeptide binding]; other site 483219009559 catalytic residue [active] 483219009560 YCII-related domain; Region: YCII; cl00999 483219009561 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 483219009562 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 483219009563 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 483219009564 active site 483219009565 catalytic tetrad [active] 483219009566 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 483219009567 ATP binding site [chemical binding]; other site 483219009568 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 483219009569 putative Mg++ binding site [ion binding]; other site 483219009570 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 483219009571 nucleotide binding region [chemical binding]; other site 483219009572 ATP-binding site [chemical binding]; other site 483219009573 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 483219009574 putative catalytic site [active] 483219009575 putative phosphate binding site [ion binding]; other site 483219009576 putative metal binding site [ion binding]; other site 483219009577 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 483219009578 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 483219009579 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 483219009580 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 483219009581 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 483219009582 putative active site [active] 483219009583 putative metal binding site [ion binding]; other site 483219009584 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 483219009585 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 483219009586 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 483219009587 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 483219009588 DNA binding residues [nucleotide binding] 483219009589 Uncharacterized conserved protein [Function unknown]; Region: COG2128 483219009590 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 483219009591 B12 binding domain; Region: B12-binding; pfam02310 483219009592 B12-binding domain/radical SAM domain protein, Ta0216 family; Region: B12_SAM_Ta0216; TIGR04190 483219009593 B12 binding site [chemical binding]; other site 483219009594 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 483219009595 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 483219009596 Uncharacterized conserved protein [Function unknown]; Region: COG5649 483219009597 DoxX-like family; Region: DoxX_2; pfam13564 483219009598 BNR repeat-like domain; Region: BNR_2; pfam13088 483219009599 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 483219009600 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 483219009601 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 483219009602 CHAT domain; Region: CHAT; pfam12770 483219009603 BioY family; Region: BioY; pfam02632 483219009604 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 483219009605 Cytochrome c552; Region: Cytochrom_C552; pfam02335 483219009606 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 483219009607 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 483219009608 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 483219009609 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 483219009610 active site 483219009611 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 483219009612 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 483219009613 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 483219009614 Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316 483219009615 Cna protein B-type domain; Region: Cna_B_2; pfam13715 483219009616 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 483219009617 Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316 483219009618 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 483219009619 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 483219009620 Dual-action HEIGH metallo-peptidase; Region: Peptidase_M57; pfam12388 483219009621 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 483219009622 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 483219009623 active site 483219009624 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 483219009625 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 483219009626 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 483219009627 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 483219009628 homodimer interface [polypeptide binding]; other site 483219009629 NADP binding site [chemical binding]; other site 483219009630 substrate binding site [chemical binding]; other site 483219009631 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 483219009632 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 483219009633 heme binding pocket [chemical binding]; other site 483219009634 heme ligand [chemical binding]; other site 483219009635 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 483219009636 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 483219009637 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 483219009638 DNA binding residues [nucleotide binding] 483219009639 dimerization interface [polypeptide binding]; other site 483219009640 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219009641 dimerization interface [polypeptide binding]; other site 483219009642 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 483219009643 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 483219009644 dimer interface [polypeptide binding]; other site 483219009645 putative CheW interface [polypeptide binding]; other site 483219009646 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 483219009647 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 483219009648 dinuclear metal binding motif [ion binding]; other site 483219009649 Pirin; Region: Pirin; pfam02678 483219009650 Pirin-related protein [General function prediction only]; Region: COG1741 483219009651 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 483219009652 A new structural DNA glycosylase; Region: AlkD_like; cd06561 483219009653 active site 483219009654 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 483219009655 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 483219009656 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 483219009657 putative NAD(P) binding site [chemical binding]; other site 483219009658 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 483219009659 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 483219009660 active site 483219009661 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 483219009662 ATP binding site [chemical binding]; other site 483219009663 putative Mg++ binding site [ion binding]; other site 483219009664 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 483219009665 nucleotide binding region [chemical binding]; other site 483219009666 ATP-binding site [chemical binding]; other site 483219009667 Uncharacterized conserved protein [Function unknown]; Region: COG3391 483219009668 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 483219009669 Methyltransferase domain; Region: Methyltransf_31; pfam13847 483219009670 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219009671 S-adenosylmethionine binding site [chemical binding]; other site 483219009672 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 483219009673 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 483219009674 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 483219009675 dimer interface [polypeptide binding]; other site 483219009676 putative CheW interface [polypeptide binding]; other site 483219009677 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219009678 S-adenosylmethionine binding site [chemical binding]; other site 483219009679 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 483219009680 FAD binding domain; Region: FAD_binding_4; pfam01565 483219009681 Berberine and berberine like; Region: BBE; pfam08031 483219009682 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 483219009683 structural tetrad; other site 483219009684 FOG: WD40 repeat [General function prediction only]; Region: COG2319 483219009685 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 483219009686 structural tetrad; other site 483219009687 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 483219009688 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 483219009689 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 483219009690 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 483219009691 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 483219009692 protein binding site [polypeptide binding]; other site 483219009693 paraquat-inducible protein B; Provisional; Region: PRK10807 483219009694 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 483219009695 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 483219009696 Walker A/P-loop; other site 483219009697 ATP binding site [chemical binding]; other site 483219009698 Q-loop/lid; other site 483219009699 ABC transporter signature motif; other site 483219009700 Walker B; other site 483219009701 D-loop; other site 483219009702 H-loop/switch region; other site 483219009703 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 483219009704 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 483219009705 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483219009706 dimer interface [polypeptide binding]; other site 483219009707 conserved gate region; other site 483219009708 putative PBP binding loops; other site 483219009709 ABC-ATPase subunit interface; other site 483219009710 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 483219009711 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 483219009712 Phosphagen (guanidino) kinases mostly found in eukaryotes; Region: eukaryotic_phosphagen_kinases; cd07931 483219009713 phosphagen binding site; other site 483219009714 ADP binding site [chemical binding]; other site 483219009715 substrate specificity loop; other site 483219009716 PS-10 peptidase S37; Region: Peptidase_S37; pfam05576 483219009717 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219009718 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219009719 active site 483219009720 ATP binding site [chemical binding]; other site 483219009721 substrate binding site [chemical binding]; other site 483219009722 activation loop (A-loop); other site 483219009723 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 483219009724 catalytic residues [active] 483219009725 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 483219009726 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 483219009727 phosphopeptide binding site; other site 483219009728 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 483219009729 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 483219009730 ATP binding site [chemical binding]; other site 483219009731 putative Mg++ binding site [ion binding]; other site 483219009732 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 483219009733 nucleotide binding region [chemical binding]; other site 483219009734 ATP-binding site [chemical binding]; other site 483219009735 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 483219009736 TPR repeat; Region: TPR_11; pfam13414 483219009737 TPR repeat; Region: TPR_11; pfam13414 483219009738 putative cation:proton antiport protein; Provisional; Region: PRK10669 483219009739 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 483219009740 TrkA-N domain; Region: TrkA_N; pfam02254 483219009741 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 483219009742 B12 binding site [chemical binding]; other site 483219009743 cobalt ligand [ion binding]; other site 483219009744 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 483219009745 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 483219009746 membrane ATPase/protein kinase; Provisional; Region: PRK09435 483219009747 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 483219009748 Walker A; other site 483219009749 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 483219009750 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 483219009751 active site 483219009752 substrate binding site [chemical binding]; other site 483219009753 coenzyme B12 binding site [chemical binding]; other site 483219009754 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 483219009755 B12 binding site [chemical binding]; other site 483219009756 cobalt ligand [ion binding]; other site 483219009757 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 483219009758 heterodimer interface [polypeptide binding]; other site 483219009759 substrate interaction site [chemical binding]; other site 483219009760 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 483219009761 RNA/DNA hybrid binding site [nucleotide binding]; other site 483219009762 active site 483219009763 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 483219009764 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 483219009765 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 483219009766 catalytic residues [active] 483219009767 Nitronate monooxygenase; Region: NMO; pfam03060 483219009768 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 483219009769 FMN binding site [chemical binding]; other site 483219009770 substrate binding site [chemical binding]; other site 483219009771 putative catalytic residue [active] 483219009772 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 483219009773 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 483219009774 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 483219009775 FtsX-like permease family; Region: FtsX; pfam02687 483219009776 Protein of unknown function, DUF488; Region: DUF488; cl01246 483219009777 GTPase RsgA; Reviewed; Region: PRK01889 483219009778 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 483219009779 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 483219009780 GTPase/Zn-binding domain interface [polypeptide binding]; other site 483219009781 GTP/Mg2+ binding site [chemical binding]; other site 483219009782 G4 box; other site 483219009783 G5 box; other site 483219009784 G1 box; other site 483219009785 Switch I region; other site 483219009786 G2 box; other site 483219009787 G3 box; other site 483219009788 Switch II region; other site 483219009789 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 483219009790 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 483219009791 substrate binding pocket [chemical binding]; other site 483219009792 membrane-bound complex binding site; other site 483219009793 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 483219009794 Zn binding site [ion binding]; other site 483219009795 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 483219009796 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 483219009797 nucleotide binding site [chemical binding]; other site 483219009798 substrate binding site [chemical binding]; other site 483219009799 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 483219009800 dimer interface [polypeptide binding]; other site 483219009801 putative threonine allosteric regulatory site; other site 483219009802 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 483219009803 putative threonine allosteric regulatory site; other site 483219009804 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 483219009805 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 483219009806 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 483219009807 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 483219009808 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 483219009809 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 483219009810 putative NAD(P) binding site [chemical binding]; other site 483219009811 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 483219009812 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 483219009813 FMN binding site [chemical binding]; other site 483219009814 active site 483219009815 catalytic residues [active] 483219009816 substrate binding site [chemical binding]; other site 483219009817 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219009818 TPR motif; other site 483219009819 binding surface 483219009820 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 483219009821 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 483219009822 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 483219009823 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 483219009824 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 483219009825 active site 483219009826 Zn binding site [ion binding]; other site 483219009827 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 483219009828 dimer interface [polypeptide binding]; other site 483219009829 substrate binding site [chemical binding]; other site 483219009830 ATP binding site [chemical binding]; other site 483219009831 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 483219009832 Interdomain contacts; other site 483219009833 Cytokine receptor motif; other site 483219009834 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 483219009835 Interdomain contacts; other site 483219009836 Cytokine receptor motif; other site 483219009837 Glyco_18 domain; Region: Glyco_18; smart00636 483219009838 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 483219009839 active site 483219009840 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 483219009841 metal binding site [ion binding]; metal-binding site 483219009842 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 483219009843 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 483219009844 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 483219009845 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 483219009846 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 483219009847 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 483219009848 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 483219009849 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 483219009850 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 483219009851 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 483219009852 PA14 domain; Region: PA14; cl08459 483219009853 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 483219009854 multidrug resistance protein MdtN; Provisional; Region: PRK10476 483219009855 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 483219009856 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 483219009857 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483219009858 putative substrate translocation pore; other site 483219009859 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 483219009860 O-methyltransferase; Region: Methyltransf_2; pfam00891 483219009861 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 483219009862 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 483219009863 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 483219009864 putative dimer interface [polypeptide binding]; other site 483219009865 putative anticodon binding site; other site 483219009866 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 483219009867 homodimer interface [polypeptide binding]; other site 483219009868 motif 1; other site 483219009869 motif 2; other site 483219009870 active site 483219009871 motif 3; other site 483219009872 CotH protein; Region: CotH; pfam08757 483219009873 Protein of unknown function (DUF2743); Region: DUF2743; pfam10899 483219009874 Gram-negative bacterial tonB protein; Region: TonB; cl10048 483219009875 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 483219009876 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 483219009877 Penicillin-insensitive murein endopeptidase; Region: Peptidase_M74; cl01538 483219009878 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 483219009879 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 483219009880 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 483219009881 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 483219009882 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 483219009883 ATP binding site [chemical binding]; other site 483219009884 putative Mg++ binding site [ion binding]; other site 483219009885 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 483219009886 nucleotide binding region [chemical binding]; other site 483219009887 ATP-binding site [chemical binding]; other site 483219009888 PIN domain; Region: PIN_3; cl17397 483219009889 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 483219009890 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439 483219009891 heme-binding residues [chemical binding]; other site 483219009892 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 483219009893 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 483219009894 putative NAD(P) binding site [chemical binding]; other site 483219009895 RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248 483219009896 ATP binding site [chemical binding]; other site 483219009897 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 483219009898 Ca2+ binding site [ion binding]; other site 483219009899 EF-hand domain pair; Region: EF_hand_6; pfam13833 483219009900 PAS domain S-box; Region: sensory_box; TIGR00229 483219009901 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219009902 putative active site [active] 483219009903 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 483219009904 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219009905 putative active site [active] 483219009906 heme pocket [chemical binding]; other site 483219009907 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219009908 dimer interface [polypeptide binding]; other site 483219009909 phosphorylation site [posttranslational modification] 483219009910 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219009911 ATP binding site [chemical binding]; other site 483219009912 Mg2+ binding site [ion binding]; other site 483219009913 G-X-G motif; other site 483219009914 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 483219009915 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219009916 active site 483219009917 phosphorylation site [posttranslational modification] 483219009918 intermolecular recognition site; other site 483219009919 Response regulator receiver domain; Region: Response_reg; pfam00072 483219009920 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219009921 active site 483219009922 phosphorylation site [posttranslational modification] 483219009923 intermolecular recognition site; other site 483219009924 dimerization interface [polypeptide binding]; other site 483219009925 Hpt domain; Region: Hpt; pfam01627 483219009926 putative binding surface; other site 483219009927 active site 483219009928 glutathione reductase; Validated; Region: PRK06116 483219009929 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 483219009930 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 483219009931 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 483219009932 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 483219009933 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 483219009934 ATP binding site [chemical binding]; other site 483219009935 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 483219009936 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 483219009937 Surface antigen; Region: Bac_surface_Ag; pfam01103 483219009938 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 483219009939 pantothenate kinase; Provisional; Region: PRK05439 483219009940 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 483219009941 ATP-binding site [chemical binding]; other site 483219009942 CoA-binding site [chemical binding]; other site 483219009943 Mg2+-binding site [ion binding]; other site 483219009944 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 483219009945 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 483219009946 NAD(P) binding site [chemical binding]; other site 483219009947 catalytic residues [active] 483219009948 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 483219009949 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 483219009950 Putative ammonia monooxygenase; Region: AmoA; pfam05145 483219009951 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 483219009952 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 483219009953 NAD-dependent deacetylase; Provisional; Region: PRK05333 483219009954 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 483219009955 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 483219009956 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 483219009957 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 483219009958 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 483219009959 putative active site [active] 483219009960 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 483219009961 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 483219009962 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 483219009963 N-acetyl-D-glucosamine binding site [chemical binding]; other site 483219009964 catalytic residue [active] 483219009965 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219009966 S-adenosylmethionine binding site [chemical binding]; other site 483219009967 sulfite reductase subunit beta; Provisional; Region: PRK13504 483219009968 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 483219009969 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 483219009970 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 483219009971 Flavodoxin; Region: Flavodoxin_1; pfam00258 483219009972 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 483219009973 FAD binding pocket [chemical binding]; other site 483219009974 FAD binding motif [chemical binding]; other site 483219009975 catalytic residues [active] 483219009976 NAD binding pocket [chemical binding]; other site 483219009977 phosphate binding motif [ion binding]; other site 483219009978 beta-alpha-beta structure motif; other site 483219009979 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 483219009980 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 483219009981 CysD dimerization site [polypeptide binding]; other site 483219009982 G1 box; other site 483219009983 putative GEF interaction site [polypeptide binding]; other site 483219009984 GTP/Mg2+ binding site [chemical binding]; other site 483219009985 Switch I region; other site 483219009986 G2 box; other site 483219009987 G3 box; other site 483219009988 Switch II region; other site 483219009989 G4 box; other site 483219009990 G5 box; other site 483219009991 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 483219009992 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 483219009993 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 483219009994 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 483219009995 Active Sites [active] 483219009996 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 483219009997 active site 483219009998 SAM binding site [chemical binding]; other site 483219009999 homodimer interface [polypeptide binding]; other site 483219010000 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 483219010001 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 483219010002 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 483219010003 Active Sites [active] 483219010004 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 483219010005 dinuclear metal binding motif [ion binding]; other site 483219010006 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 483219010007 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 483219010008 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cl16915 483219010009 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 483219010010 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 483219010011 dimerization interface [polypeptide binding]; other site 483219010012 ATP binding site [chemical binding]; other site 483219010013 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 483219010014 dimerization interface [polypeptide binding]; other site 483219010015 ATP binding site [chemical binding]; other site 483219010016 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 483219010017 putative active site [active] 483219010018 catalytic triad [active] 483219010019 Domain of unknown function (DUF2019); Region: DUF2019; pfam09450 483219010020 methionine sulfoxide reductase B; Provisional; Region: PRK00222 483219010021 SelR domain; Region: SelR; pfam01641 483219010022 FOG: CBS domain [General function prediction only]; Region: COG0517 483219010023 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 483219010024 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 483219010025 active site 483219010026 dimer interface [polypeptide binding]; other site 483219010027 motif 1; other site 483219010028 motif 2; other site 483219010029 motif 3; other site 483219010030 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 483219010031 anticodon binding site; other site 483219010032 OPT oligopeptide transporter protein; Region: OPT; cl14607 483219010033 oligopeptide transporter, OPT superfamily; Region: OPT_sfam; TIGR00728 483219010034 OPT oligopeptide transporter protein; Region: OPT; cl14607 483219010035 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 483219010036 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 483219010037 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 483219010038 diaminopimelate decarboxylase; Region: lysA; TIGR01048 483219010039 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 483219010040 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 483219010041 catalytic residue [active] 483219010042 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 483219010043 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 483219010044 active site 483219010045 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 483219010046 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 483219010047 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 483219010048 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 483219010049 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 483219010050 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 483219010051 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 483219010052 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 483219010053 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 483219010054 putative ADP-binding pocket [chemical binding]; other site 483219010055 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 483219010056 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 483219010057 active site 483219010058 HIGH motif; other site 483219010059 nucleotide binding site [chemical binding]; other site 483219010060 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 483219010061 KMSKS motif; other site 483219010062 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 483219010063 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 483219010064 Beta-lactamase; Region: Beta-lactamase; pfam00144 483219010065 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219010066 Tetratricopeptide repeat; Region: TPR_16; pfam13432 483219010067 TPR motif; other site 483219010068 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 483219010069 Coenzyme A binding pocket [chemical binding]; other site 483219010070 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219010071 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 483219010072 putative active site [active] 483219010073 heme pocket [chemical binding]; other site 483219010074 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219010075 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 483219010076 putative active site [active] 483219010077 heme pocket [chemical binding]; other site 483219010078 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219010079 putative active site [active] 483219010080 heme pocket [chemical binding]; other site 483219010081 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 483219010082 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 483219010083 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219010084 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219010085 dimer interface [polypeptide binding]; other site 483219010086 phosphorylation site [posttranslational modification] 483219010087 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219010088 ATP binding site [chemical binding]; other site 483219010089 Mg2+ binding site [ion binding]; other site 483219010090 G-X-G motif; other site 483219010091 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 483219010092 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 483219010093 active site 483219010094 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 483219010095 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 483219010096 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 483219010097 active site 483219010098 SUMO-1 interface [polypeptide binding]; other site 483219010099 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 483219010100 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 483219010101 putative substrate binding site [chemical binding]; other site 483219010102 putative ATP binding site [chemical binding]; other site 483219010103 Protein of unknown function (DUF423); Region: DUF423; pfam04241 483219010104 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 483219010105 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 483219010106 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 483219010107 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 483219010108 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 483219010109 active site 483219010110 metal binding site [ion binding]; metal-binding site 483219010111 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 483219010112 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 483219010113 Ligand binding site; other site 483219010114 DXD motif; other site 483219010115 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 483219010116 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 483219010117 PAS domain S-box; Region: sensory_box; TIGR00229 483219010118 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219010119 putative active site [active] 483219010120 heme pocket [chemical binding]; other site 483219010121 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 483219010122 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219010123 putative active site [active] 483219010124 heme pocket [chemical binding]; other site 483219010125 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219010126 dimer interface [polypeptide binding]; other site 483219010127 phosphorylation site [posttranslational modification] 483219010128 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219010129 ATP binding site [chemical binding]; other site 483219010130 Mg2+ binding site [ion binding]; other site 483219010131 G-X-G motif; other site 483219010132 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 483219010133 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219010134 active site 483219010135 phosphorylation site [posttranslational modification] 483219010136 intermolecular recognition site; other site 483219010137 dimerization interface [polypeptide binding]; other site 483219010138 Protein of unknown function (DUF2378); Region: DUF2378; pfam09536 483219010139 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 483219010140 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219010141 Walker A/P-loop; other site 483219010142 ATP binding site [chemical binding]; other site 483219010143 Q-loop/lid; other site 483219010144 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219010145 ABC transporter signature motif; other site 483219010146 Walker B; other site 483219010147 D-loop; other site 483219010148 H-loop/switch region; other site 483219010149 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219010150 Walker A/P-loop; other site 483219010151 ATP binding site [chemical binding]; other site 483219010152 Q-loop/lid; other site 483219010153 ABC transporter signature motif; other site 483219010154 Walker B; other site 483219010155 D-loop; other site 483219010156 H-loop/switch region; other site 483219010157 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219010158 Walker A/P-loop; other site 483219010159 ATP binding site [chemical binding]; other site 483219010160 Q-loop/lid; other site 483219010161 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 483219010162 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 483219010163 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219010164 ABC transporter signature motif; other site 483219010165 Walker B; other site 483219010166 D-loop; other site 483219010167 H-loop/switch region; other site 483219010168 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219010169 Walker A/P-loop; other site 483219010170 ATP binding site [chemical binding]; other site 483219010171 Q-loop/lid; other site 483219010172 ABC transporter signature motif; other site 483219010173 Walker B; other site 483219010174 D-loop; other site 483219010175 H-loop/switch region; other site 483219010176 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 483219010177 catalytic residues [active] 483219010178 dimer interface [polypeptide binding]; other site 483219010179 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 483219010180 RNA polymerase sigma factor; Provisional; Region: PRK12513 483219010181 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 483219010182 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 483219010183 DNA binding residues [nucleotide binding] 483219010184 Protein of unknown function (DUF2378); Region: DUF2378; cl15288 483219010185 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 483219010186 catalytic triad [active] 483219010187 putative methanogenesis marker protein 1; Region: methan_mark_1; TIGR03266 483219010188 YcaO-like family; Region: YcaO; pfam02624 483219010189 Uncharacterized conserved protein [Function unknown]; Region: COG3482 483219010190 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219010191 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219010192 active site 483219010193 ATP binding site [chemical binding]; other site 483219010194 substrate binding site [chemical binding]; other site 483219010195 activation loop (A-loop); other site 483219010196 Myxococcus xanthus paralogous family TIGR02268; Region: TIGR02268 483219010197 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 483219010198 DNA methylase; Region: N6_N4_Mtase; pfam01555 483219010199 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 483219010200 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 483219010201 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 483219010202 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 483219010203 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 483219010204 oligopeptide transporter, OPT superfamily; Region: OPT_sfam; TIGR00728 483219010205 OPT oligopeptide transporter protein; Region: OPT; pfam03169 483219010206 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 483219010207 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219010208 Walker A/P-loop; other site 483219010209 ATP binding site [chemical binding]; other site 483219010210 Q-loop/lid; other site 483219010211 ABC transporter signature motif; other site 483219010212 Walker B; other site 483219010213 D-loop; other site 483219010214 H-loop/switch region; other site 483219010215 ABC transporter; Region: ABC_tran_2; pfam12848 483219010216 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 483219010217 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 483219010218 elongation factor G; Reviewed; Region: PRK12740 483219010219 G1 box; other site 483219010220 putative GEF interaction site [polypeptide binding]; other site 483219010221 GTP/Mg2+ binding site [chemical binding]; other site 483219010222 Switch I region; other site 483219010223 G2 box; other site 483219010224 G3 box; other site 483219010225 Switch II region; other site 483219010226 G4 box; other site 483219010227 G5 box; other site 483219010228 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091 483219010229 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 483219010230 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_C; cd04097 483219010231 SnoaL-like domain; Region: SnoaL_2; pfam12680 483219010232 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 483219010233 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 483219010234 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 483219010235 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 483219010236 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 483219010237 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 483219010238 RNA binding surface [nucleotide binding]; other site 483219010239 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 483219010240 active site 483219010241 uracil binding [chemical binding]; other site 483219010242 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 483219010243 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 483219010244 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 483219010245 MG2 domain; Region: A2M_N; pfam01835 483219010246 Alpha-2-macroglobulin family; Region: A2M; pfam00207 483219010247 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 483219010248 surface patch; other site 483219010249 thioester region; other site 483219010250 Catalytic domain of vertebrate phospholipase D6 and similar proteins; Region: PLDc_vPLD6_like; cd09171 483219010251 PLD-like domain; Region: PLDc_2; pfam13091 483219010252 putative active site [active] 483219010253 catalytic site [active] 483219010254 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 483219010255 Transglycosylase; Region: Transgly; pfam00912 483219010256 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 483219010257 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 483219010258 CotH protein; Region: CotH; pfam08757 483219010259 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 483219010260 Surface antigen; Region: Bac_surface_Ag; pfam01103 483219010261 Uncharacterized conserved protein [Function unknown]; Region: COG5276 483219010262 LVIVD repeat; Region: LVIVD; pfam08309 483219010263 LVIVD repeat; Region: LVIVD; pfam08309 483219010264 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 483219010265 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 483219010266 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 483219010267 FtsX-like permease family; Region: FtsX; pfam02687 483219010268 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 483219010269 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 483219010270 FtsX-like permease family; Region: FtsX; pfam02687 483219010271 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 483219010272 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 483219010273 Walker A/P-loop; other site 483219010274 ATP binding site [chemical binding]; other site 483219010275 Q-loop/lid; other site 483219010276 ABC transporter signature motif; other site 483219010277 Walker B; other site 483219010278 D-loop; other site 483219010279 H-loop/switch region; other site 483219010280 Predicted transcriptional regulators [Transcription]; Region: COG1510 483219010281 putative DNA binding site [nucleotide binding]; other site 483219010282 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 483219010283 putative Zn2+ binding site [ion binding]; other site 483219010284 TPR repeat; Region: TPR_11; pfam13414 483219010285 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219010286 binding surface 483219010287 TPR motif; other site 483219010288 TPR repeat; Region: TPR_11; pfam13414 483219010289 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 483219010290 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 483219010291 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 483219010292 DNA binding residues [nucleotide binding] 483219010293 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 483219010294 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 483219010295 putative trimer interface [polypeptide binding]; other site 483219010296 putative CoA binding site [chemical binding]; other site 483219010297 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 483219010298 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 483219010299 Flagellar assembly protein FliH; Region: FliH; pfam02108 483219010300 type III secretion apparatus H+-transporting two-sector ATPase; Region: III_secr_ATP; TIGR02546 483219010301 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 483219010302 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 483219010303 Walker A motif/ATP binding site; other site 483219010304 Walker B motif; other site 483219010305 Peptidase S46; Region: Peptidase_S46; pfam10459 483219010306 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 483219010307 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 483219010308 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 483219010309 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 483219010310 type III secretion system protein; Reviewed; Region: PRK09617 483219010311 Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987 483219010312 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 483219010313 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 483219010314 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 483219010315 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 483219010316 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 483219010317 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219010318 TPR motif; other site 483219010319 binding surface 483219010320 Domain of Unknown Function (DUF1521); Region: DUF1521; pfam07481 483219010321 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 483219010322 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219010323 binding surface 483219010324 TPR motif; other site 483219010325 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219010326 TPR motif; other site 483219010327 binding surface 483219010328 TPR repeat; Region: TPR_11; pfam13414 483219010329 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 483219010330 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 483219010331 FHIPEP family; Region: FHIPEP; pfam00771 483219010332 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 483219010333 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 483219010334 phosphopeptide binding site; other site 483219010335 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 483219010336 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 483219010337 phosphopeptide binding site; other site 483219010338 TPR repeat; Region: TPR_11; pfam13414 483219010339 TPR repeat; Region: TPR_11; pfam13414 483219010340 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219010341 binding surface 483219010342 TPR motif; other site 483219010343 TPR repeat; Region: TPR_11; pfam13414 483219010344 TPR repeat; Region: TPR_11; pfam13414 483219010345 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219010346 TPR motif; other site 483219010347 binding surface 483219010348 OmpW family; Region: OmpW; cl17427 483219010349 RDD family; Region: RDD; pfam06271 483219010350 TLC ATP/ADP transporter; Region: TLC; cl03940 483219010351 HEAT repeats; Region: HEAT_2; pfam13646 483219010352 HEAT repeats; Region: HEAT_2; pfam13646 483219010353 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 483219010354 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 483219010355 ligand binding site [chemical binding]; other site 483219010356 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 483219010357 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 483219010358 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 483219010359 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 483219010360 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219010361 TPR motif; other site 483219010362 binding surface 483219010363 Integral membrane protein DUF95; Region: DUF95; pfam01944 483219010364 Inorganic pyrophosphatase; Region: Pyrophosphatase; pfam00719 483219010365 dimer interface [polypeptide binding]; other site 483219010366 metal binding sites [ion binding]; metal-binding site 483219010367 Inorganic pyrophosphatase; Region: Pyrophosphatase; pfam00719 483219010368 metal binding sites [ion binding]; metal-binding site 483219010369 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 483219010370 Protein of unknown function DUF58; Region: DUF58; pfam01882 483219010371 MoxR-like ATPases [General function prediction only]; Region: COG0714 483219010372 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219010373 Walker A motif; other site 483219010374 ATP binding site [chemical binding]; other site 483219010375 Walker B motif; other site 483219010376 arginine finger; other site 483219010377 transcription termination factor Rho; Provisional; Region: PRK12608 483219010378 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 483219010379 Walker A motif; other site 483219010380 ATP binding site [chemical binding]; other site 483219010381 Walker B motif; other site 483219010382 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 483219010383 tandem repeat interface [polypeptide binding]; other site 483219010384 oligomer interface [polypeptide binding]; other site 483219010385 active site residues [active] 483219010386 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 483219010387 tandem repeat interface [polypeptide binding]; other site 483219010388 oligomer interface [polypeptide binding]; other site 483219010389 active site residues [active] 483219010390 PEGA domain; Region: PEGA; pfam08308 483219010391 PEGA domain; Region: PEGA; pfam08308 483219010392 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 483219010393 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219010394 Mg2+ binding site [ion binding]; other site 483219010395 G-X-G motif; other site 483219010396 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 483219010397 anchoring element; other site 483219010398 dimer interface [polypeptide binding]; other site 483219010399 ATP binding site [chemical binding]; other site 483219010400 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 483219010401 active site 483219010402 putative metal-binding site [ion binding]; other site 483219010403 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 483219010404 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 483219010405 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 483219010406 CAP-like domain; other site 483219010407 active site 483219010408 primary dimer interface [polypeptide binding]; other site 483219010409 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 483219010410 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 483219010411 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 483219010412 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 483219010413 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 483219010414 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 483219010415 Peptidase S46; Region: Peptidase_S46; pfam10459 483219010416 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 483219010417 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 483219010418 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 483219010419 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 483219010420 DNA binding residues [nucleotide binding] 483219010421 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 483219010422 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 483219010423 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 483219010424 phosphopeptide binding site; other site 483219010425 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219010426 Walker A motif; other site 483219010427 ATP binding site [chemical binding]; other site 483219010428 Walker B motif; other site 483219010429 arginine finger; other site 483219010430 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 483219010431 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 483219010432 Type II secretion system (T2SS), protein M; Region: T2SM; cl01222 483219010433 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 483219010434 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 483219010435 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 483219010436 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 483219010437 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 483219010438 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 483219010439 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 483219010440 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 483219010441 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 483219010442 type II secretion system protein F; Region: GspF; TIGR02120 483219010443 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 483219010444 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 483219010445 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 483219010446 type II secretion system protein E; Region: type_II_gspE; TIGR02533 483219010447 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 483219010448 Walker A motif; other site 483219010449 ATP binding site [chemical binding]; other site 483219010450 Walker B motif; other site 483219010451 potential frameshift: common BLAST hit: gi|108757430|ref|YP_630733.1| general secretion pathway protein D 483219010452 type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713 483219010453 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 483219010454 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 483219010455 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 483219010456 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219010457 active site 483219010458 phosphorylation site [posttranslational modification] 483219010459 intermolecular recognition site; other site 483219010460 dimerization interface [polypeptide binding]; other site 483219010461 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219010462 Walker A motif; other site 483219010463 ATP binding site [chemical binding]; other site 483219010464 Walker B motif; other site 483219010465 arginine finger; other site 483219010466 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 483219010467 ParB-like nuclease domain; Region: ParB; smart00470 483219010468 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 483219010469 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 483219010470 Tocopherol cyclase; Region: Tocopherol_cycl; cl14571 483219010471 protease TldD; Provisional; Region: tldD; PRK10735 483219010472 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 483219010473 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 483219010474 phosphopeptide binding site; other site 483219010475 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219010476 binding surface 483219010477 Tetratricopeptide repeat; Region: TPR_16; pfam13432 483219010478 TPR motif; other site 483219010479 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 483219010480 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 483219010481 ligand binding site [chemical binding]; other site 483219010482 flexible hinge region; other site 483219010483 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 483219010484 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 483219010485 ligand binding site [chemical binding]; other site 483219010486 flexible hinge region; other site 483219010487 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 483219010488 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 483219010489 putative active site [active] 483219010490 putative substrate binding site [chemical binding]; other site 483219010491 ATP binding site [chemical binding]; other site 483219010492 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 483219010493 SnoaL-like domain; Region: SnoaL_3; pfam13474 483219010494 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 483219010495 Myxococcus xanthus paralogous domain TIGR02266; Region: gmx_TIGR02266 483219010496 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 483219010497 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 483219010498 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 483219010499 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 483219010500 2-enoyl thioester reductase (ETR) like proteins, child 1; Region: ETR_like_1; cd08291 483219010501 NADP binding site [chemical binding]; other site 483219010502 dimer interface [polypeptide binding]; other site 483219010503 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 483219010504 putative deacylase active site [active] 483219010505 phosphoribosylaminoimidazole carboxylase, PurK protein; Region: purK; TIGR01161 483219010506 ATP-grasp domain; Region: ATP-grasp; pfam02222 483219010507 AIR carboxylase; Region: AIRC; pfam00731 483219010508 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 483219010509 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 483219010510 acyl-activating enzyme (AAE) consensus motif; other site 483219010511 putative AMP binding site [chemical binding]; other site 483219010512 putative active site [active] 483219010513 putative CoA binding site [chemical binding]; other site 483219010514 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 483219010515 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 483219010516 metal ion-dependent adhesion site (MIDAS); other site 483219010517 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 483219010518 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483219010519 Major Facilitator Superfamily; Region: MFS_1; pfam07690 483219010520 putative substrate translocation pore; other site 483219010521 putative phosphate acyltransferase; Provisional; Region: PRK05331 483219010522 Uncharacterized conserved protein [Function unknown]; Region: COG4850 483219010523 poly(A) polymerase; Region: pcnB; TIGR01942 483219010524 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 483219010525 active site 483219010526 NTP binding site [chemical binding]; other site 483219010527 metal binding triad [ion binding]; metal-binding site 483219010528 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 483219010529 active site 483219010530 DNA polymerase IV; Validated; Region: PRK02406 483219010531 DNA binding site [nucleotide binding] 483219010532 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 483219010533 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 483219010534 RNA binding surface [nucleotide binding]; other site 483219010535 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 483219010536 active site 483219010537 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 483219010538 active site 483219010539 ATP binding site [chemical binding]; other site 483219010540 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219010541 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 483219010542 substrate binding site [chemical binding]; other site 483219010543 activation loop (A-loop); other site 483219010544 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219010545 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219010546 active site 483219010547 ATP binding site [chemical binding]; other site 483219010548 substrate binding site [chemical binding]; other site 483219010549 activation loop (A-loop); other site 483219010550 PEGA domain; Region: PEGA; pfam08308 483219010551 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 483219010552 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 483219010553 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 483219010554 Predicted transcriptional regulator [Transcription]; Region: COG2378 483219010555 HTH domain; Region: HTH_11; pfam08279 483219010556 WYL domain; Region: WYL; pfam13280 483219010557 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 483219010558 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 483219010559 catalytic residue [active] 483219010560 putative FPP diphosphate binding site; other site 483219010561 putative FPP binding hydrophobic cleft; other site 483219010562 dimer interface [polypeptide binding]; other site 483219010563 putative IPP diphosphate binding site; other site 483219010564 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 483219010565 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 483219010566 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 483219010567 active site 483219010568 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 483219010569 protein binding site [polypeptide binding]; other site 483219010570 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 483219010571 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 483219010572 protein binding site [polypeptide binding]; other site 483219010573 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 483219010574 putative substrate binding region [chemical binding]; other site 483219010575 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 483219010576 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 483219010577 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 483219010578 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 483219010579 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 483219010580 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 483219010581 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 483219010582 MoaE interaction surface [polypeptide binding]; other site 483219010583 MoeB interaction surface [polypeptide binding]; other site 483219010584 thiocarboxylated glycine; other site 483219010585 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 483219010586 MoaE homodimer interface [polypeptide binding]; other site 483219010587 MoaD interaction [polypeptide binding]; other site 483219010588 active site residues [active] 483219010589 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483219010590 putative substrate translocation pore; other site 483219010591 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 483219010592 active site 483219010593 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 483219010594 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 483219010595 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 483219010596 nudix motif; other site 483219010597 acetyl-CoA synthetase; Provisional; Region: PRK00174 483219010598 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 483219010599 active site 483219010600 CoA binding site [chemical binding]; other site 483219010601 acyl-activating enzyme (AAE) consensus motif; other site 483219010602 AMP binding site [chemical binding]; other site 483219010603 acetate binding site [chemical binding]; other site 483219010604 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 483219010605 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 483219010606 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 483219010607 catalytic residue [active] 483219010608 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 483219010609 catalytic core [active] 483219010610 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 483219010611 RNA/DNA hybrid binding site [nucleotide binding]; other site 483219010612 active site 483219010613 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 483219010614 B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; Region: BBOX; cl00034 483219010615 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 483219010616 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 483219010617 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 483219010618 protein binding site [polypeptide binding]; other site 483219010619 16S rRNA methyltransferase B; Provisional; Region: PRK14904 483219010620 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219010621 S-adenosylmethionine binding site [chemical binding]; other site 483219010622 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 483219010623 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 483219010624 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 483219010625 active site 483219010626 metal binding site [ion binding]; metal-binding site 483219010627 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 483219010628 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 483219010629 TMP-binding site; other site 483219010630 ATP-binding site [chemical binding]; other site 483219010631 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 483219010632 putative active site; other site 483219010633 putative metal binding residues [ion binding]; other site 483219010634 signature motif; other site 483219010635 putative triphosphate binding site [ion binding]; other site 483219010636 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219010637 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219010638 active site 483219010639 ATP binding site [chemical binding]; other site 483219010640 substrate binding site [chemical binding]; other site 483219010641 activation loop (A-loop); other site 483219010642 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 483219010643 active site residue [active] 483219010644 molybdopterin biosynthesis protein MoeB; Validated; Region: PRK08762 483219010645 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 483219010646 active site residue [active] 483219010647 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 483219010648 ATP binding site [chemical binding]; other site 483219010649 substrate interface [chemical binding]; other site 483219010650 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 483219010651 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 483219010652 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 483219010653 AAA domain; Region: AAA_18; pfam13238 483219010654 Substrate-binding site [chemical binding]; other site 483219010655 Substrate specificity [chemical binding]; other site 483219010656 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 483219010657 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 483219010658 putative active site [active] 483219010659 catalytic site [active] 483219010660 putative metal binding site [ion binding]; other site 483219010661 Bacterial Ig-like domain; Region: Big_5; pfam13205 483219010662 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 483219010663 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219010664 active site 483219010665 ATP binding site [chemical binding]; other site 483219010666 substrate binding site [chemical binding]; other site 483219010667 activation loop (A-loop); other site 483219010668 Protein of unknown function DUF45; Region: DUF45; cl00636 483219010669 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219010670 S-adenosylmethionine binding site [chemical binding]; other site 483219010671 quinolinate synthetase; Provisional; Region: PRK09375 483219010672 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 483219010673 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219010674 S-adenosylmethionine binding site [chemical binding]; other site 483219010675 Centrosome localisation domain of PPC89; Region: Cep57_CLD_2; pfam14197 483219010676 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219010677 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219010678 ATP binding site [chemical binding]; other site 483219010679 Mg2+ binding site [ion binding]; other site 483219010680 G-X-G motif; other site 483219010681 Response regulator receiver domain; Region: Response_reg; pfam00072 483219010682 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219010683 active site 483219010684 phosphorylation site [posttranslational modification] 483219010685 intermolecular recognition site; other site 483219010686 dimerization interface [polypeptide binding]; other site 483219010687 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219010688 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219010689 dimer interface [polypeptide binding]; other site 483219010690 phosphorylation site [posttranslational modification] 483219010691 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219010692 ATP binding site [chemical binding]; other site 483219010693 Mg2+ binding site [ion binding]; other site 483219010694 G-X-G motif; other site 483219010695 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 483219010696 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483219010697 putative substrate translocation pore; other site 483219010698 POT family; Region: PTR2; cl17359 483219010699 Major Facilitator Superfamily; Region: MFS_1; pfam07690 483219010700 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483219010701 POT family; Region: PTR2; cl17359 483219010702 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 483219010703 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 483219010704 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 483219010705 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 483219010706 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 483219010707 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 483219010708 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 483219010709 tetramer interface [polypeptide binding]; other site 483219010710 active site 483219010711 Mg2+/Mn2+ binding site [ion binding]; other site 483219010712 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 483219010713 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 483219010714 DNA binding site [nucleotide binding] 483219010715 active site 483219010716 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 483219010717 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 483219010718 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 483219010719 AlkA N-terminal domain; Region: AlkA_N; pfam06029 483219010720 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 483219010721 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 483219010722 minor groove reading motif; other site 483219010723 helix-hairpin-helix signature motif; other site 483219010724 substrate binding pocket [chemical binding]; other site 483219010725 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 483219010726 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 483219010727 active site 483219010728 metal binding site [ion binding]; metal-binding site 483219010729 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 483219010730 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 483219010731 active site 483219010732 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 483219010733 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 483219010734 Coenzyme A binding pocket [chemical binding]; other site 483219010735 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 483219010736 ATP-dependent nuclease, subunit B [DNA replication, recombination, and repair]; Region: AddB; COG3857 483219010737 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 483219010738 Family description; Region: UvrD_C_2; pfam13538 483219010739 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 483219010740 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 483219010741 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 483219010742 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 483219010743 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219010744 binding surface 483219010745 TPR motif; other site 483219010746 Uncharacterized protein conserved in bacteria containing a divergent form of TPR repeats [Function unknown]; Region: COG4700 483219010747 TPR repeat; Region: TPR_11; pfam13414 483219010748 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219010749 binding surface 483219010750 TPR motif; other site 483219010751 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 483219010752 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 483219010753 phosphopeptide binding site; other site 483219010754 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 483219010755 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 483219010756 putative ligand binding site [chemical binding]; other site 483219010757 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 483219010758 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 483219010759 Competence protein; Region: Competence; pfam03772 483219010760 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 483219010761 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 483219010762 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 483219010763 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 483219010764 phosphopeptide binding site; other site 483219010765 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 483219010766 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 483219010767 active site 483219010768 HIGH motif; other site 483219010769 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 483219010770 KMSKS motif; other site 483219010771 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 483219010772 tRNA binding surface [nucleotide binding]; other site 483219010773 anticodon binding site; other site 483219010774 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 483219010775 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 483219010776 PA/protease or protease-like domain interface [polypeptide binding]; other site 483219010777 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660 483219010778 Peptidase family M28; Region: Peptidase_M28; pfam04389 483219010779 metal binding site [ion binding]; metal-binding site 483219010780 excinuclease ABC subunit B; Provisional; Region: PRK05298 483219010781 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 483219010782 ATP binding site [chemical binding]; other site 483219010783 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 483219010784 nucleotide binding region [chemical binding]; other site 483219010785 ATP-binding site [chemical binding]; other site 483219010786 Ultra-violet resistance protein B; Region: UvrB; pfam12344 483219010787 UvrB/uvrC motif; Region: UVR; pfam02151 483219010788 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 483219010789 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 483219010790 GIY-YIG motif/motif A; other site 483219010791 active site 483219010792 catalytic site [active] 483219010793 putative DNA binding site [nucleotide binding]; other site 483219010794 metal binding site [ion binding]; metal-binding site 483219010795 UvrB/uvrC motif; Region: UVR; pfam02151 483219010796 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 483219010797 Protein of unknown function (DUF507); Region: DUF507; pfam04368 483219010798 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 483219010799 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 483219010800 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 483219010801 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 483219010802 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 483219010803 catalytic residue [active] 483219010804 Maf-like protein; Region: Maf; pfam02545 483219010805 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 483219010806 active site 483219010807 dimer interface [polypeptide binding]; other site 483219010808 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 483219010809 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 483219010810 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 483219010811 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 483219010812 metal binding site [ion binding]; metal-binding site 483219010813 active site 483219010814 I-site; other site 483219010815 SurA N-terminal domain; Region: SurA_N_3; cl07813 483219010816 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 483219010817 rod shape-determining protein MreC; Provisional; Region: PRK13922 483219010818 rod shape-determining protein MreC; Region: MreC; pfam04085 483219010819 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 483219010820 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 483219010821 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 483219010822 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 483219010823 PilZ domain; Region: PilZ; pfam07238 483219010824 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 483219010825 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 483219010826 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 483219010827 catalytic residues [active] 483219010828 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 483219010829 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 483219010830 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 483219010831 tRNA; other site 483219010832 putative tRNA binding site [nucleotide binding]; other site 483219010833 putative NADP binding site [chemical binding]; other site 483219010834 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 483219010835 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 483219010836 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 483219010837 domain interfaces; other site 483219010838 active site 483219010839 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 483219010840 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 483219010841 active site 483219010842 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 483219010843 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 483219010844 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 483219010845 Walker A motif; other site 483219010846 ATP binding site [chemical binding]; other site 483219010847 Walker B motif; other site 483219010848 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 483219010849 generic binding surface I; other site 483219010850 generic binding surface II; other site 483219010851 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 483219010852 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 483219010853 active site 483219010854 metal binding site [ion binding]; metal-binding site 483219010855 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 483219010856 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 483219010857 nudix motif; other site 483219010858 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 483219010859 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483219010860 putative substrate translocation pore; other site 483219010861 Periplasmic lysozyme inhibitor, I-type (PliI) and similar proteins; Region: PliI_like; cd09632 483219010862 Family description; Region: VCBS; pfam13517 483219010863 putative inhibitory loop; other site 483219010864 Family description; Region: VCBS; pfam13517 483219010865 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 483219010866 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 483219010867 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 483219010868 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 483219010869 tetramer interface [polypeptide binding]; other site 483219010870 TPP-binding site [chemical binding]; other site 483219010871 heterodimer interface [polypeptide binding]; other site 483219010872 phosphorylation loop region [posttranslational modification] 483219010873 pyruvate dehydrogenase subunit beta; Validated; Region: PRK09212 483219010874 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 483219010875 alpha subunit interface [polypeptide binding]; other site 483219010876 TPP binding site [chemical binding]; other site 483219010877 heterodimer interface [polypeptide binding]; other site 483219010878 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 483219010879 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 483219010880 E3 interaction surface; other site 483219010881 lipoyl attachment site [posttranslational modification]; other site 483219010882 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 483219010883 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 483219010884 E3 interaction surface; other site 483219010885 lipoyl attachment site [posttranslational modification]; other site 483219010886 e3 binding domain; Region: E3_binding; pfam02817 483219010887 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 483219010888 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 483219010889 Response regulator receiver domain; Region: Response_reg; pfam00072 483219010890 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219010891 active site 483219010892 phosphorylation site [posttranslational modification] 483219010893 intermolecular recognition site; other site 483219010894 dimerization interface [polypeptide binding]; other site 483219010895 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219010896 ATP binding site [chemical binding]; other site 483219010897 Mg2+ binding site [ion binding]; other site 483219010898 G-X-G motif; other site 483219010899 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219010900 active site 483219010901 phosphorylation site [posttranslational modification] 483219010902 intermolecular recognition site; other site 483219010903 dimerization interface [polypeptide binding]; other site 483219010904 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 483219010905 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 483219010906 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 483219010907 active site 483219010908 KMSKS motif; other site 483219010909 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 483219010910 active site 483219010911 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 483219010912 active site 483219010913 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 483219010914 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 483219010915 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219010916 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219010917 active site 483219010918 ATP binding site [chemical binding]; other site 483219010919 substrate binding site [chemical binding]; other site 483219010920 activation loop (A-loop); other site 483219010921 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 483219010922 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 483219010923 CheW-like domain; Region: CheW; pfam01584 483219010924 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 483219010925 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 483219010926 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 483219010927 dimerization interface [polypeptide binding]; other site 483219010928 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 483219010929 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 483219010930 dimer interface [polypeptide binding]; other site 483219010931 putative CheW interface [polypeptide binding]; other site 483219010932 Response regulator receiver domain; Region: Response_reg; pfam00072 483219010933 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219010934 active site 483219010935 phosphorylation site [posttranslational modification] 483219010936 intermolecular recognition site; other site 483219010937 dimerization interface [polypeptide binding]; other site 483219010938 CheW-like domain; Region: CheW; pfam01584 483219010939 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 483219010940 putative binding surface; other site 483219010941 active site 483219010942 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219010943 ATP binding site [chemical binding]; other site 483219010944 Mg2+ binding site [ion binding]; other site 483219010945 G-X-G motif; other site 483219010946 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 483219010947 Response regulator receiver domain; Region: Response_reg; pfam00072 483219010948 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219010949 active site 483219010950 phosphorylation site [posttranslational modification] 483219010951 intermolecular recognition site; other site 483219010952 dimerization interface [polypeptide binding]; other site 483219010953 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219010954 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219010955 dimer interface [polypeptide binding]; other site 483219010956 phosphorylation site [posttranslational modification] 483219010957 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 483219010958 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 483219010959 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 483219010960 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 483219010961 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 483219010962 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219010963 dimer interface [polypeptide binding]; other site 483219010964 phosphorylation site [posttranslational modification] 483219010965 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219010966 ATP binding site [chemical binding]; other site 483219010967 Mg2+ binding site [ion binding]; other site 483219010968 G-X-G motif; other site 483219010969 Response regulator receiver domain; Region: Response_reg; pfam00072 483219010970 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219010971 active site 483219010972 phosphorylation site [posttranslational modification] 483219010973 intermolecular recognition site; other site 483219010974 dimerization interface [polypeptide binding]; other site 483219010975 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 483219010976 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 483219010977 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 483219010978 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 483219010979 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 483219010980 G1 box; other site 483219010981 GTP/Mg2+ binding site [chemical binding]; other site 483219010982 G2 box; other site 483219010983 Switch I region; other site 483219010984 G3 box; other site 483219010985 Switch II region; other site 483219010986 G4 box; other site 483219010987 G5 box; other site 483219010988 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 483219010989 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 483219010990 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 483219010991 motif II; other site 483219010992 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 483219010993 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 483219010994 substrate binding site [chemical binding]; other site 483219010995 oxyanion hole (OAH) forming residues; other site 483219010996 trimer interface [polypeptide binding]; other site 483219010997 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 483219010998 Protein of unknown function (DUF523); Region: DUF523; pfam04463 483219010999 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 483219011000 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 483219011001 active site 483219011002 substrate binding site [chemical binding]; other site 483219011003 cosubstrate binding site; other site 483219011004 catalytic site [active] 483219011005 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 483219011006 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 483219011007 dimerization interface [polypeptide binding]; other site 483219011008 putative ATP binding site [chemical binding]; other site 483219011009 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 483219011010 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 483219011011 ligand binding site [chemical binding]; other site 483219011012 flexible hinge region; other site 483219011013 cAMP phosphodiesterases class-II; Region: PDEase_II; cl17776 483219011014 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 483219011015 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 483219011016 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 483219011017 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 483219011018 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 483219011019 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 483219011020 AMIN domain; Region: AMIN; pfam11741 483219011021 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219011022 binding surface 483219011023 TPR motif; other site 483219011024 Tetratricopeptide repeat; Region: TPR_16; pfam13432 483219011025 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 483219011026 Organic solvent tolerance protein; Region: OstA_C; pfam04453 483219011027 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 483219011028 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 483219011029 non-specific DNA binding site [nucleotide binding]; other site 483219011030 salt bridge; other site 483219011031 sequence-specific DNA binding site [nucleotide binding]; other site 483219011032 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 483219011033 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 483219011034 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 483219011035 enoyl-CoA hydratase; Validated; Region: PRK08139 483219011036 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 483219011037 substrate binding site [chemical binding]; other site 483219011038 oxyanion hole (OAH) forming residues; other site 483219011039 trimer interface [polypeptide binding]; other site 483219011040 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 483219011041 Peptidase family M23; Region: Peptidase_M23; pfam01551 483219011042 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 483219011043 putative catalytic site [active] 483219011044 putative metal binding site [ion binding]; other site 483219011045 putative phosphate binding site [ion binding]; other site 483219011046 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 483219011047 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 483219011048 CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080 483219011049 CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080 483219011050 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 483219011051 cyclase homology domain; Region: CHD; cd07302 483219011052 nucleotidyl binding site; other site 483219011053 metal binding site [ion binding]; metal-binding site 483219011054 dimer interface [polypeptide binding]; other site 483219011055 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 483219011056 dimer interface [polypeptide binding]; other site 483219011057 [2Fe-2S] cluster binding site [ion binding]; other site 483219011058 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 483219011059 4Fe-4S binding domain; Region: Fer4; pfam00037 483219011060 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 483219011061 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 483219011062 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 483219011063 catalytic loop [active] 483219011064 iron binding site [ion binding]; other site 483219011065 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 483219011066 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 483219011067 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 483219011068 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 483219011069 NADH dehydrogenase subunit D; Validated; Region: PRK06075 483219011070 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 483219011071 Sulfatase; Region: Sulfatase; cl17466 483219011072 NADH dehydrogenase subunit B; Provisional; Region: PRK14817 483219011073 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 483219011074 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219011075 dimerization interface [polypeptide binding]; other site 483219011076 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 483219011077 dimer interface [polypeptide binding]; other site 483219011078 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 483219011079 putative CheW interface [polypeptide binding]; other site 483219011080 amphi-Trp domain; Region: amphi-Trp; TIGR04354 483219011081 RNA polymerase sigma-70 factor, Myxococcales family 1; Region: Sig-70_gmx1; TIGR03001 483219011082 Putative zinc-finger; Region: zf-HC2; pfam13490 483219011083 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219011084 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219011085 active site 483219011086 ATP binding site [chemical binding]; other site 483219011087 substrate binding site [chemical binding]; other site 483219011088 activation loop (A-loop); other site 483219011089 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 483219011090 Tetratricopeptide repeat; Region: TPR_12; pfam13424 483219011091 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219011092 TPR motif; other site 483219011093 Tetratricopeptide repeat; Region: TPR_12; pfam13424 483219011094 binding surface 483219011095 Tetratricopeptide repeat; Region: TPR_12; pfam13424 483219011096 Tetratricopeptide repeat; Region: TPR_12; pfam13424 483219011097 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 483219011098 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 483219011099 active site 483219011100 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 483219011101 Deoxyhypusine synthase; Region: DS; cl00826 483219011102 deoxyhypusine synthase; Region: dhys; TIGR00321 483219011103 OsmC-like protein; Region: OsmC; pfam02566 483219011104 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 483219011105 Uncharacterized conserved protein [Function unknown]; Region: COG2353 483219011106 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 483219011107 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 483219011108 dimer interface [polypeptide binding]; other site 483219011109 active site 483219011110 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 483219011111 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 483219011112 NAD(P) binding site [chemical binding]; other site 483219011113 active site 483219011114 Transcriptional regulator [Transcription]; Region: LysR; COG0583 483219011115 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 483219011116 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 483219011117 putative effector binding pocket; other site 483219011118 dimerization interface [polypeptide binding]; other site 483219011119 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 483219011120 CoenzymeA binding site [chemical binding]; other site 483219011121 subunit interaction site [polypeptide binding]; other site 483219011122 PHB binding site; other site 483219011123 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 483219011124 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 483219011125 active site 483219011126 FAD binding domain; Region: FAD_binding_3; pfam01494 483219011127 hypothetical protein; Provisional; Region: PRK07236 483219011128 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 483219011129 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 483219011130 active site 483219011131 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 483219011132 Ligand Binding Site [chemical binding]; other site 483219011133 Molecular Tunnel; other site 483219011134 arginine decarboxylase; Provisional; Region: PRK05354 483219011135 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 483219011136 active site 483219011137 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 483219011138 catalytic residues [active] 483219011139 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 483219011140 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 483219011141 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219011142 Walker A motif; other site 483219011143 ATP binding site [chemical binding]; other site 483219011144 Walker B motif; other site 483219011145 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 483219011146 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 483219011147 Colicin V production protein; Region: Colicin_V; pfam02674 483219011148 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 483219011149 HSP70 interaction site [polypeptide binding]; other site 483219011150 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 483219011151 nucleotide binding site [chemical binding]; other site 483219011152 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 483219011153 active site 483219011154 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 483219011155 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219011156 ATP binding site [chemical binding]; other site 483219011157 Mg2+ binding site [ion binding]; other site 483219011158 G-X-G motif; other site 483219011159 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 483219011160 Uncharacterized conserved protein [Function unknown]; Region: COG5470 483219011161 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 483219011162 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 483219011163 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 483219011164 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 483219011165 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 483219011166 active site 483219011167 Zn binding site [ion binding]; other site 483219011168 CAAX protease self-immunity; Region: Abi; pfam02517 483219011169 hypothetical protein; Provisional; Region: PRK08609 483219011170 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 483219011171 active site 483219011172 primer binding site [nucleotide binding]; other site 483219011173 NTP binding site [chemical binding]; other site 483219011174 metal binding triad [ion binding]; metal-binding site 483219011175 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 483219011176 active site 483219011177 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 483219011178 iron-sulfur cluster [ion binding]; other site 483219011179 [2Fe-2S] cluster binding site [ion binding]; other site 483219011180 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 483219011181 MPT binding site; other site 483219011182 trimer interface [polypeptide binding]; other site 483219011183 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase; Region: M28_AAP; cd03879 483219011184 Peptidase family M28; Region: Peptidase_M28; pfam04389 483219011185 active site 483219011186 metal binding site [ion binding]; metal-binding site 483219011187 Yqey-like protein; Region: YqeY; cl17540 483219011188 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 483219011189 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219011190 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219011191 dimer interface [polypeptide binding]; other site 483219011192 phosphorylation site [posttranslational modification] 483219011193 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219011194 ATP binding site [chemical binding]; other site 483219011195 G-X-G motif; other site 483219011196 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219011197 Response regulator receiver domain; Region: Response_reg; pfam00072 483219011198 active site 483219011199 phosphorylation site [posttranslational modification] 483219011200 intermolecular recognition site; other site 483219011201 dimerization interface [polypeptide binding]; other site 483219011202 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 483219011203 Predicted esterase [General function prediction only]; Region: COG0400 483219011204 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 483219011205 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 483219011206 hydroxyglutarate oxidase; Provisional; Region: PRK11728 483219011207 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219011208 binding surface 483219011209 TPR repeat; Region: TPR_11; pfam13414 483219011210 TPR motif; other site 483219011211 TPR repeat; Region: TPR_11; pfam13414 483219011212 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 483219011213 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 483219011214 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219011215 active site 483219011216 phosphorylation site [posttranslational modification] 483219011217 intermolecular recognition site; other site 483219011218 dimerization interface [polypeptide binding]; other site 483219011219 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 483219011220 DNA binding site [nucleotide binding] 483219011221 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219011222 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219011223 dimer interface [polypeptide binding]; other site 483219011224 phosphorylation site [posttranslational modification] 483219011225 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219011226 ATP binding site [chemical binding]; other site 483219011227 Mg2+ binding site [ion binding]; other site 483219011228 G-X-G motif; other site 483219011229 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 483219011230 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 483219011231 PAS fold; Region: PAS_4; pfam08448 483219011232 GAF domain; Region: GAF_3; pfam13492 483219011233 GAF domain; Region: GAF_2; pfam13185 483219011234 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219011235 PAS fold; Region: PAS_3; pfam08447 483219011236 putative active site [active] 483219011237 heme pocket [chemical binding]; other site 483219011238 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 483219011239 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219011240 putative active site [active] 483219011241 heme pocket [chemical binding]; other site 483219011242 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219011243 dimer interface [polypeptide binding]; other site 483219011244 phosphorylation site [posttranslational modification] 483219011245 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219011246 ATP binding site [chemical binding]; other site 483219011247 Mg2+ binding site [ion binding]; other site 483219011248 G-X-G motif; other site 483219011249 Response regulator receiver domain; Region: Response_reg; pfam00072 483219011250 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219011251 active site 483219011252 phosphorylation site [posttranslational modification] 483219011253 intermolecular recognition site; other site 483219011254 dimerization interface [polypeptide binding]; other site 483219011255 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 483219011256 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 483219011257 dimer interface [polypeptide binding]; other site 483219011258 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 483219011259 active site 483219011260 Fe binding site [ion binding]; other site 483219011261 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 483219011262 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 483219011263 iron-sulfur cluster [ion binding]; other site 483219011264 [2Fe-2S] cluster binding site [ion binding]; other site 483219011265 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 483219011266 Peptidase propeptide and YPEB domain; Region: PepSY_2; pfam13670 483219011267 Dual-action HEIGH metallo-peptidase; Region: Peptidase_M57; pfam12388 483219011268 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 483219011269 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 483219011270 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 483219011271 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219011272 Walker A/P-loop; other site 483219011273 ATP binding site [chemical binding]; other site 483219011274 Q-loop/lid; other site 483219011275 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 483219011276 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219011277 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 483219011278 Walker A/P-loop; other site 483219011279 ATP binding site [chemical binding]; other site 483219011280 Q-loop/lid; other site 483219011281 ABC transporter signature motif; other site 483219011282 Walker B; other site 483219011283 D-loop; other site 483219011284 H-loop/switch region; other site 483219011285 MAC/Perforin domain; Region: MACPF; cl02616 483219011286 N-terminal formyl transferase catalytic core domain of NRPS_like proteins, one of the proteins involved in the synthesis of Oxazolomycin; Region: FMT_core_NRPS_like; cd08649 483219011287 putative active site [active] 483219011288 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 483219011289 putative substrate binding site [chemical binding]; other site 483219011290 putative cosubstrate binding site; other site 483219011291 catalytic site [active] 483219011292 C-terminal subdomain of the Formyltransferase-like domain found in OzmH-like proteins; Region: FMT_C_OzmH_like; cd08700 483219011293 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219011294 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 483219011295 acyl-activating enzyme (AAE) consensus motif; other site 483219011296 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 483219011297 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 483219011298 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 483219011299 AMP binding site [chemical binding]; other site 483219011300 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219011301 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 483219011302 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 483219011303 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 483219011304 active site 483219011305 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 483219011306 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 483219011307 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 483219011308 NAD(P) binding site [chemical binding]; other site 483219011309 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 483219011310 active site 483219011311 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 483219011312 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219011313 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 483219011314 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 483219011315 Mechanosensitive ion channel; Region: MS_channel; pfam00924 483219011316 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 483219011317 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 483219011318 ligand binding site [chemical binding]; other site 483219011319 flexible hinge region; other site 483219011320 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 483219011321 DNA polymerase III subunit delta'; Validated; Region: PRK08485 483219011322 ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470 483219011323 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 483219011324 DNA polymerase III, delta subunit; Region: holA; TIGR01128 483219011325 NRDE protein; Region: NRDE; cl01315 483219011326 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 483219011327 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 483219011328 active site 483219011329 HIGH motif; other site 483219011330 KMSKS motif; other site 483219011331 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 483219011332 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 483219011333 dimer interface [polypeptide binding]; other site 483219011334 putative tRNA-binding site [nucleotide binding]; other site 483219011335 putative lyase; Provisional; Region: PRK09687 483219011336 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 483219011337 active site 483219011338 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 483219011339 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 483219011340 Zn2+ binding site [ion binding]; other site 483219011341 Mg2+ binding site [ion binding]; other site 483219011342 Response regulator receiver domain; Region: Response_reg; pfam00072 483219011343 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219011344 active site 483219011345 phosphorylation site [posttranslational modification] 483219011346 intermolecular recognition site; other site 483219011347 dimerization interface [polypeptide binding]; other site 483219011348 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 483219011349 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 483219011350 generic binding surface II; other site 483219011351 generic binding surface I; other site 483219011352 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 483219011353 Zn2+ binding site [ion binding]; other site 483219011354 Mg2+ binding site [ion binding]; other site 483219011355 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 483219011356 PUA domain; Region: PUA; cl00607 483219011357 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 483219011358 putative RNA binding site [nucleotide binding]; other site 483219011359 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219011360 S-adenosylmethionine binding site [chemical binding]; other site 483219011361 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 483219011362 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 483219011363 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 483219011364 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 483219011365 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 483219011366 active site 483219011367 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 483219011368 Interdomain contacts; other site 483219011369 Cytokine receptor motif; other site 483219011370 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 483219011371 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 483219011372 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 483219011373 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 483219011374 Phosphoglycerate kinase; Region: PGK; pfam00162 483219011375 substrate binding site [chemical binding]; other site 483219011376 hinge regions; other site 483219011377 ADP binding site [chemical binding]; other site 483219011378 catalytic site [active] 483219011379 triosephosphate isomerase; Provisional; Region: PRK14565 483219011380 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 483219011381 dimer interface [polypeptide binding]; other site 483219011382 substrate binding site [chemical binding]; other site 483219011383 catalytic triad [active] 483219011384 Radical SAM superfamily; Region: Radical_SAM; pfam04055 483219011385 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 483219011386 FeS/SAM binding site; other site 483219011387 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 483219011388 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 483219011389 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219011390 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 483219011391 Walker A motif; other site 483219011392 ATP binding site [chemical binding]; other site 483219011393 Walker B motif; other site 483219011394 arginine finger; other site 483219011395 Winged helix-turn helix; Region: HTH_29; pfam13551 483219011396 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 483219011397 Integrase core domain; Region: rve; pfam00665 483219011398 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 483219011399 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 483219011400 non-specific DNA binding site [nucleotide binding]; other site 483219011401 salt bridge; other site 483219011402 sequence-specific DNA binding site [nucleotide binding]; other site 483219011403 TPR repeat; Region: TPR_11; pfam13414 483219011404 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219011405 binding surface 483219011406 TPR motif; other site 483219011407 TPR repeat; Region: TPR_11; pfam13414 483219011408 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 483219011409 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 483219011410 putative DNA binding site [nucleotide binding]; other site 483219011411 dimerization interface [polypeptide binding]; other site 483219011412 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 483219011413 putative Zn2+ binding site [ion binding]; other site 483219011414 transposase/IS protein; Provisional; Region: PRK09183 483219011415 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219011416 Walker A motif; other site 483219011417 ATP binding site [chemical binding]; other site 483219011418 Walker B motif; other site 483219011419 arginine finger; other site 483219011420 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 483219011421 Integrase core domain; Region: rve; pfam00665 483219011422 Domain of unknown function (DUF932); Region: DUF932; cl12129 483219011423 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219011424 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219011425 active site 483219011426 ATP binding site [chemical binding]; other site 483219011427 substrate binding site [chemical binding]; other site 483219011428 activation loop (A-loop); other site 483219011429 Protein of unknown function (DUF2381); Region: DUF2381; pfam09544 483219011430 Homeodomain-like domain; Region: HTH_32; pfam13565 483219011431 putative transposase OrfB; Reviewed; Region: PHA02517 483219011432 Integrase core domain; Region: rve; pfam00665 483219011433 Integrase core domain; Region: rve_3; pfam13683 483219011434 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 483219011435 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 483219011436 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 483219011437 O-methyltransferase; Region: Methyltransf_2; pfam00891 483219011438 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 483219011439 classical (c) SDRs; Region: SDR_c; cd05233 483219011440 NAD(P) binding site [chemical binding]; other site 483219011441 active site 483219011442 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 483219011443 Protein kinase domain; Region: Pkinase; pfam00069 483219011444 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219011445 active site 483219011446 ATP binding site [chemical binding]; other site 483219011447 substrate binding site [chemical binding]; other site 483219011448 activation loop (A-loop); other site 483219011449 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 483219011450 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 483219011451 NAD(P) binding site [chemical binding]; other site 483219011452 catalytic residues [active] 483219011453 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 483219011454 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 483219011455 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 483219011456 dimerization interface [polypeptide binding]; other site 483219011457 acetolactate synthase; Reviewed; Region: PRK08322 483219011458 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 483219011459 PYR/PP interface [polypeptide binding]; other site 483219011460 dimer interface [polypeptide binding]; other site 483219011461 TPP binding site [chemical binding]; other site 483219011462 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 483219011463 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 483219011464 TPP-binding site [chemical binding]; other site 483219011465 dimer interface [polypeptide binding]; other site 483219011466 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 483219011467 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 483219011468 NAD(P) binding site [chemical binding]; other site 483219011469 catalytic residues [active] 483219011470 Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313 483219011471 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 483219011472 active site 483219011473 catalytic site [active] 483219011474 hypothetical protein; Provisional; Region: PRK11568 483219011475 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 483219011476 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 483219011477 recombination factor protein RarA; Reviewed; Region: PRK13342 483219011478 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219011479 Walker A motif; other site 483219011480 ATP binding site [chemical binding]; other site 483219011481 Walker B motif; other site 483219011482 arginine finger; other site 483219011483 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 483219011484 TIGR03118 family protein; Region: PEPCTERM_chp_1 483219011485 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 483219011486 Nudix hydrolase homolog; Region: PLN02791 483219011487 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 483219011488 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 483219011489 Amidase; Region: Amidase; pfam01425 483219011490 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 483219011491 Peptidase C39 family; Region: Peptidase_C39; pfam03412 483219011492 putative active site [active] 483219011493 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 483219011494 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219011495 Walker A/P-loop; other site 483219011496 ATP binding site [chemical binding]; other site 483219011497 Q-loop/lid; other site 483219011498 ABC transporter signature motif; other site 483219011499 Walker B; other site 483219011500 D-loop; other site 483219011501 H-loop/switch region; other site 483219011502 type 2 lantibiotic, mersacidin/lichenicidin family; Region: lanti_MRSA_kill; TIGR03898 483219011503 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 483219011504 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 483219011505 active site 483219011506 zinc binding site [ion binding]; other site 483219011507 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 483219011508 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 483219011509 ATP binding site [chemical binding]; other site 483219011510 putative Mg++ binding site [ion binding]; other site 483219011511 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 483219011512 nucleotide binding region [chemical binding]; other site 483219011513 ATP-binding site [chemical binding]; other site 483219011514 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 483219011515 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 483219011516 homodimer interface [polypeptide binding]; other site 483219011517 homotetramer interface [polypeptide binding]; other site 483219011518 active site pocket [active] 483219011519 cleavage site 483219011520 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 483219011521 Putative Ig domain; Region: He_PIG; pfam05345 483219011522 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 483219011523 putative catalytic site [active] 483219011524 putative metal binding site [ion binding]; other site 483219011525 putative phosphate binding site [ion binding]; other site 483219011526 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 483219011527 Lamin Tail Domain; Region: LTD; pfam00932 483219011528 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 483219011529 Domain of unknown function DUF20; Region: UPF0118; pfam01594 483219011530 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 483219011531 Zn binding site [ion binding]; other site 483219011532 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 483219011533 Ferritin-like domain; Region: Ferritin; pfam00210 483219011534 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 483219011535 dinuclear metal binding motif [ion binding]; other site 483219011536 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_2; cd07805 483219011537 N- and C-terminal domain interface [polypeptide binding]; other site 483219011538 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 483219011539 active site 483219011540 MgATP binding site [chemical binding]; other site 483219011541 catalytic site [active] 483219011542 metal binding site [ion binding]; metal-binding site 483219011543 xylulose binding site [chemical binding]; other site 483219011544 putative homodimer interface [polypeptide binding]; other site 483219011545 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 483219011546 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 483219011547 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 483219011548 catalytic residue [active] 483219011549 HEAT repeats; Region: HEAT_2; pfam13646 483219011550 potential frameshift: common BLAST hit: gi|108762947|ref|YP_631800.1| IS21 family transposase 483219011551 Integrase core domain; Region: rve_3; cl15866 483219011552 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 483219011553 active site 483219011554 catalytic triad [active] 483219011555 dimer interface [polypeptide binding]; other site 483219011556 Transposase, Mutator family; Region: Transposase_mut; pfam00872 483219011557 MULE transposase domain; Region: MULE; pfam10551 483219011558 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 483219011559 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183 483219011560 putative active site [active] 483219011561 metal binding site [ion binding]; metal-binding site 483219011562 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 483219011563 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 483219011564 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 483219011565 AAA ATPase domain; Region: AAA_16; pfam13191 483219011566 Tetratricopeptide repeat; Region: TPR_12; pfam13424 483219011567 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219011568 binding surface 483219011569 TPR repeat; Region: TPR_11; pfam13414 483219011570 TPR motif; other site 483219011571 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 483219011572 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 483219011573 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 483219011574 motif II; other site 483219011575 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 483219011576 coproporphyrinogen III oxidase; Validated; Region: PRK08208 483219011577 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 483219011578 HemN C-terminal domain; Region: HemN_C; pfam06969 483219011579 Radical SAM superfamily; Region: Radical_SAM; pfam04055 483219011580 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 483219011581 FeS/SAM binding site; other site 483219011582 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 483219011583 repeat-companion domain TIGR02996; Region: rpt_mate_G_obs 483219011584 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 483219011585 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 483219011586 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219011587 Walker A motif; other site 483219011588 ATP binding site [chemical binding]; other site 483219011589 Walker B motif; other site 483219011590 arginine finger; other site 483219011591 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219011592 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 483219011593 Walker A motif; other site 483219011594 ATP binding site [chemical binding]; other site 483219011595 Walker B motif; other site 483219011596 arginine finger; other site 483219011597 Peptidase family M41; Region: Peptidase_M41; pfam01434 483219011598 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 483219011599 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 483219011600 FeS/SAM binding site; other site 483219011601 PilZ domain; Region: PilZ; pfam07238 483219011602 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219011603 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 483219011604 Walker A motif; other site 483219011605 ATP binding site [chemical binding]; other site 483219011606 Walker B motif; other site 483219011607 arginine finger; other site 483219011608 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 483219011609 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 483219011610 ATP binding site [chemical binding]; other site 483219011611 substrate interface [chemical binding]; other site 483219011612 potential frameshift: common BLAST hit: gi|108760169|ref|YP_631117.1| penicillin acylase family protein 483219011613 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 483219011614 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 483219011615 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 483219011616 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219011617 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219011618 active site 483219011619 ATP binding site [chemical binding]; other site 483219011620 substrate binding site [chemical binding]; other site 483219011621 activation loop (A-loop); other site 483219011622 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219011623 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219011624 active site 483219011625 ATP binding site [chemical binding]; other site 483219011626 substrate binding site [chemical binding]; other site 483219011627 activation loop (A-loop); other site 483219011628 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 483219011629 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 483219011630 DNA binding residues [nucleotide binding] 483219011631 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 483219011632 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 483219011633 purine monophosphate binding site [chemical binding]; other site 483219011634 dimer interface [polypeptide binding]; other site 483219011635 putative catalytic residues [active] 483219011636 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 483219011637 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 483219011638 zinc-ribbon domain; Region: zinc_ribbon_4; pfam13717 483219011639 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219011640 TPR motif; other site 483219011641 binding surface 483219011642 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 483219011643 binding surface 483219011644 TPR motif; other site 483219011645 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 483219011646 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 483219011647 ATP-grasp domain; Region: ATP-grasp_4; cl17255 483219011648 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 483219011649 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 483219011650 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 483219011651 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 483219011652 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 483219011653 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 483219011654 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 483219011655 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 483219011656 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 483219011657 putative ADP-binding pocket [chemical binding]; other site 483219011658 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 483219011659 CoA binding domain; Region: CoA_binding; smart00881 483219011660 Bacterial sugar transferase; Region: Bac_transf; pfam02397 483219011661 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 483219011662 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 483219011663 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 483219011664 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 483219011665 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 483219011666 active site 483219011667 dimer interface [polypeptide binding]; other site 483219011668 effector binding site; other site 483219011669 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 483219011670 TSCPD domain; Region: TSCPD; pfam12637 483219011671 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 483219011672 dimer interface [polypeptide binding]; other site 483219011673 [2Fe-2S] cluster binding site [ion binding]; other site 483219011674 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 483219011675 Glyco_18 domain; Region: Glyco_18; smart00636 483219011676 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 483219011677 active site 483219011678 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 483219011679 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 483219011680 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 483219011681 DNA binding residues [nucleotide binding] 483219011682 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219011683 TPR repeat; Region: TPR_11; pfam13414 483219011684 binding surface 483219011685 TPR motif; other site 483219011686 beta propeller repeat, Methanosarcina surface protein type; Region: beta_prop_Msarc; TIGR04275 483219011687 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 483219011688 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 483219011689 Isochorismatase family; Region: Isochorismatase; pfam00857 483219011690 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 483219011691 catalytic triad [active] 483219011692 dimer interface [polypeptide binding]; other site 483219011693 conserved cis-peptide bond; other site 483219011694 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 483219011695 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 483219011696 ABC-ATPase subunit interface; other site 483219011697 dimer interface [polypeptide binding]; other site 483219011698 putative PBP binding regions; other site 483219011699 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 483219011700 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219011701 Walker A/P-loop; other site 483219011702 ATP binding site [chemical binding]; other site 483219011703 Q-loop/lid; other site 483219011704 ABC transporter signature motif; other site 483219011705 Walker B; other site 483219011706 D-loop; other site 483219011707 H-loop/switch region; other site 483219011708 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 483219011709 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 483219011710 intersubunit interface [polypeptide binding]; other site 483219011711 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 483219011712 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 483219011713 iron-sulfur cluster [ion binding]; other site 483219011714 [2Fe-2S] cluster binding site [ion binding]; other site 483219011715 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 483219011716 GTP cyclohydrolase I; Provisional; Region: PLN03044 483219011717 active site 483219011718 FAD binding domain; Region: FAD_binding_4; pfam01565 483219011719 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 483219011720 HisG, C-terminal domain; Region: HisG_C; cl06867 483219011721 alternative sigma factor RpoH; Region: rpoH_proteo; TIGR02392 483219011722 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 483219011723 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 483219011724 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 483219011725 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219011726 TPR motif; other site 483219011727 binding surface 483219011728 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 483219011729 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 483219011730 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 483219011731 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 483219011732 acyl-activating enzyme (AAE) consensus motif; other site 483219011733 acyl-activating enzyme (AAE) consensus motif; other site 483219011734 putative AMP binding site [chemical binding]; other site 483219011735 putative active site [active] 483219011736 putative CoA binding site [chemical binding]; other site 483219011737 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 483219011738 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219011739 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219011740 dimer interface [polypeptide binding]; other site 483219011741 phosphorylation site [posttranslational modification] 483219011742 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219011743 Response regulator receiver domain; Region: Response_reg; pfam00072 483219011744 active site 483219011745 phosphorylation site [posttranslational modification] 483219011746 intermolecular recognition site; other site 483219011747 dimerization interface [polypeptide binding]; other site 483219011748 SCP-2 sterol transfer family; Region: SCP2; pfam02036 483219011749 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 483219011750 CoA-transferase family III; Region: CoA_transf_3; pfam02515 483219011751 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 483219011752 MarR family; Region: MarR; pfam01047 483219011753 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 483219011754 Protein export membrane protein; Region: SecD_SecF; cl14618 483219011755 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 483219011756 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 483219011757 HlyD family secretion protein; Region: HlyD_3; pfam13437 483219011758 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 483219011759 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 483219011760 active site 483219011761 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 483219011762 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 483219011763 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 483219011764 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 483219011765 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219011766 S-adenosylmethionine binding site [chemical binding]; other site 483219011767 MG2 domain; Region: A2M_N; pfam01835 483219011768 Alpha-2-macroglobulin family; Region: A2M; pfam00207 483219011769 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 483219011770 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 483219011771 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 483219011772 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 483219011773 active site 483219011774 HIGH motif; other site 483219011775 dimer interface [polypeptide binding]; other site 483219011776 KMSKS motif; other site 483219011777 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 483219011778 RNA binding surface [nucleotide binding]; other site 483219011779 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 483219011780 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 483219011781 putative active site [active] 483219011782 metal binding site [ion binding]; metal-binding site 483219011783 homodimer binding site [polypeptide binding]; other site 483219011784 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 483219011785 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 483219011786 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 483219011787 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 483219011788 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219011789 active site 483219011790 ATP binding site [chemical binding]; other site 483219011791 substrate binding site [chemical binding]; other site 483219011792 activation loop (A-loop); other site 483219011793 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 483219011794 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 483219011795 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 483219011796 N-terminal domain interface [polypeptide binding]; other site 483219011797 dimer interface [polypeptide binding]; other site 483219011798 substrate binding pocket (H-site) [chemical binding]; other site 483219011799 circadian clock protein KaiC; Reviewed; Region: PRK09302 483219011800 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 483219011801 Walker A motif; other site 483219011802 ATP binding site [chemical binding]; other site 483219011803 Walker B motif; other site 483219011804 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 483219011805 Walker A motif; other site 483219011806 ATP binding site [chemical binding]; other site 483219011807 Walker B motif; other site 483219011808 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219011809 active site 483219011810 phosphorylation site [posttranslational modification] 483219011811 intermolecular recognition site; other site 483219011812 dimerization interface [polypeptide binding]; other site 483219011813 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219011814 dimer interface [polypeptide binding]; other site 483219011815 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219011816 phosphorylation site [posttranslational modification] 483219011817 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219011818 ATP binding site [chemical binding]; other site 483219011819 Mg2+ binding site [ion binding]; other site 483219011820 G-X-G motif; other site 483219011821 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 483219011822 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 483219011823 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 483219011824 catalytic residue [active] 483219011825 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 483219011826 DHH family; Region: DHH; pfam01368 483219011827 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 483219011828 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 483219011829 Fic/DOC family; Region: Fic; pfam02661 483219011830 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 483219011831 Walker A motif; other site 483219011832 ATP binding site [chemical binding]; other site 483219011833 Walker B motif; other site 483219011834 arginine finger; other site 483219011835 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 483219011836 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 483219011837 homodimer interface [polypeptide binding]; other site 483219011838 substrate-cofactor binding pocket; other site 483219011839 catalytic residue [active] 483219011840 Patatin-like phospholipase; Region: Patatin; pfam01734 483219011841 nucleophile elbow; other site 483219011842 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219011843 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 483219011844 Walker A motif; other site 483219011845 ATP binding site [chemical binding]; other site 483219011846 Walker B motif; other site 483219011847 arginine finger; other site 483219011848 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219011849 active site 483219011850 phosphorylation site [posttranslational modification] 483219011851 intermolecular recognition site; other site 483219011852 dimerization interface [polypeptide binding]; other site 483219011853 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 483219011854 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 483219011855 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 483219011856 Uncharacterized conserved protein [Function unknown]; Region: COG1543 483219011857 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 483219011858 active site 483219011859 substrate binding site [chemical binding]; other site 483219011860 catalytic site [active] 483219011861 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 483219011862 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 483219011863 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 483219011864 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 483219011865 protein binding site [polypeptide binding]; other site 483219011866 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 483219011867 protein binding site [polypeptide binding]; other site 483219011868 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 483219011869 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219011870 dimerization interface [polypeptide binding]; other site 483219011871 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 483219011872 GAF domain; Region: GAF; pfam01590 483219011873 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 483219011874 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 483219011875 metal binding site [ion binding]; metal-binding site 483219011876 active site 483219011877 I-site; other site 483219011878 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 483219011879 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 483219011880 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 483219011881 Tetratricopeptide repeat; Region: TPR_6; pfam13174 483219011882 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 483219011883 DNA protecting protein DprA; Region: dprA; TIGR00732 483219011884 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 483219011885 DNA topoisomerase I; Validated; Region: PRK06599 483219011886 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 483219011887 active site 483219011888 interdomain interaction site; other site 483219011889 putative metal-binding site [ion binding]; other site 483219011890 nucleotide binding site [chemical binding]; other site 483219011891 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 483219011892 domain I; other site 483219011893 DNA binding groove [nucleotide binding] 483219011894 phosphate binding site [ion binding]; other site 483219011895 domain II; other site 483219011896 domain III; other site 483219011897 nucleotide binding site [chemical binding]; other site 483219011898 catalytic site [active] 483219011899 domain IV; other site 483219011900 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 483219011901 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 483219011902 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 483219011903 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 483219011904 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 483219011905 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 483219011906 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 483219011907 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 483219011908 Glucose inhibited division protein A; Region: GIDA; pfam01134 483219011909 Fibrobacter succinogenes paralogous family TIGR02171; Region: Fb_sc_TIGR02171 483219011910 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 483219011911 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 483219011912 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 483219011913 active site 483219011914 DNA binding site [nucleotide binding] 483219011915 Int/Topo IB signature motif; other site 483219011916 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 483219011917 active site 483219011918 HslU subunit interaction site [polypeptide binding]; other site 483219011919 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 483219011920 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219011921 Walker A motif; other site 483219011922 ATP binding site [chemical binding]; other site 483219011923 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 483219011924 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 483219011925 acetylornithine aminotransferase; Provisional; Region: PRK02627 483219011926 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 483219011927 inhibitor-cofactor binding pocket; inhibition site 483219011928 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483219011929 catalytic residue [active] 483219011930 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 483219011931 HSP70 interaction site [polypeptide binding]; other site 483219011932 TPR repeat; Region: TPR_11; pfam13414 483219011933 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219011934 TPR motif; other site 483219011935 binding surface 483219011936 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 483219011937 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 483219011938 nucleotide binding site [chemical binding]; other site 483219011939 TPR repeat; Region: TPR_11; pfam13414 483219011940 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 483219011941 active site 483219011942 catalytic site [active] 483219011943 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 483219011944 active site 2 [active] 483219011945 active site 1 [active] 483219011946 thioester reductase domain; Region: Thioester-redct; TIGR01746 483219011947 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 483219011948 putative NAD(P) binding site [chemical binding]; other site 483219011949 active site 483219011950 putative substrate binding site [chemical binding]; other site 483219011951 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 483219011952 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 483219011953 CoA-binding site [chemical binding]; other site 483219011954 ATP-binding [chemical binding]; other site 483219011955 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 483219011956 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 483219011957 G1 box; other site 483219011958 GTP/Mg2+ binding site [chemical binding]; other site 483219011959 Switch I region; other site 483219011960 G2 box; other site 483219011961 G3 box; other site 483219011962 Switch II region; other site 483219011963 G4 box; other site 483219011964 G5 box; other site 483219011965 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 483219011966 O-Antigen ligase; Region: Wzy_C; cl04850 483219011967 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 483219011968 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 483219011969 putative ADP-binding pocket [chemical binding]; other site 483219011970 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 483219011971 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 483219011972 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 483219011973 quinone interaction residues [chemical binding]; other site 483219011974 active site 483219011975 catalytic residues [active] 483219011976 FMN binding site [chemical binding]; other site 483219011977 substrate binding site [chemical binding]; other site 483219011978 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 483219011979 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 483219011980 active site 483219011981 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 483219011982 Smr domain; Region: Smr; pfam01713 483219011983 tellurium resistance terB-like protein; Region: terB_like; cd07177 483219011984 metal binding site [ion binding]; metal-binding site 483219011985 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 483219011986 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 483219011987 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 483219011988 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 483219011989 homodimer interface [polypeptide binding]; other site 483219011990 NADP binding site [chemical binding]; other site 483219011991 substrate binding site [chemical binding]; other site 483219011992 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219011993 S-adenosylmethionine binding site [chemical binding]; other site 483219011994 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 483219011995 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219011996 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219011997 dimer interface [polypeptide binding]; other site 483219011998 phosphorylation site [posttranslational modification] 483219011999 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219012000 ATP binding site [chemical binding]; other site 483219012001 Mg2+ binding site [ion binding]; other site 483219012002 G-X-G motif; other site 483219012003 Myxococcales-restricted protein, TIGR02265 family; Region: Mxa_TIGR02265 483219012004 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 483219012005 FAD binding site [chemical binding]; other site 483219012006 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 483219012007 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 483219012008 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 483219012009 lipoyl attachment site [posttranslational modification]; other site 483219012010 glycine dehydrogenase; Provisional; Region: PRK05367 483219012011 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 483219012012 tetramer interface [polypeptide binding]; other site 483219012013 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483219012014 catalytic residue [active] 483219012015 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 483219012016 tetramer interface [polypeptide binding]; other site 483219012017 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483219012018 catalytic residue [active] 483219012019 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 483219012020 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 483219012021 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 483219012022 Stage II sporulation protein; Region: SpoIID; pfam08486 483219012023 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 483219012024 Right handed beta helix region; Region: Beta_helix; pfam13229 483219012025 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 483219012026 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 483219012027 active site 483219012028 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 483219012029 active site residue [active] 483219012030 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 483219012031 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 483219012032 Ferredoxin [Energy production and conversion]; Region: COG1146 483219012033 4Fe-4S binding domain; Region: Fer4; pfam00037 483219012034 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 483219012035 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 483219012036 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 483219012037 Coenzyme A binding pocket [chemical binding]; other site 483219012038 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 483219012039 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 483219012040 ATP binding site [chemical binding]; other site 483219012041 putative Mg++ binding site [ion binding]; other site 483219012042 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 483219012043 nucleotide binding region [chemical binding]; other site 483219012044 Helicase associated domain (HA2); Region: HA2; pfam04408 483219012045 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 483219012046 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 483219012047 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 483219012048 motif II; other site 483219012049 HEAT-like repeat; Region: HEAT_EZ; pfam13513 483219012050 von Willebrand factor type A domain; Region: VWA_2; pfam13519 483219012051 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 483219012052 ATP-grasp domain; Region: ATP-grasp_4; cl17255 483219012053 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 483219012054 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 483219012055 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 483219012056 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 483219012057 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 483219012058 elongation factor Tu; Reviewed; Region: PRK12736 483219012059 G1 box; other site 483219012060 GEF interaction site [polypeptide binding]; other site 483219012061 GTP/Mg2+ binding site [chemical binding]; other site 483219012062 Switch I region; other site 483219012063 G2 box; other site 483219012064 G3 box; other site 483219012065 Switch II region; other site 483219012066 G4 box; other site 483219012067 G5 box; other site 483219012068 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 483219012069 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 483219012070 Antibiotic Binding Site [chemical binding]; other site 483219012071 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 483219012072 Antibiotic Binding Site [chemical binding]; other site 483219012073 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 483219012074 Antibiotic Binding Site [chemical binding]; other site 483219012075 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 483219012076 Antibiotic Binding Site [chemical binding]; other site 483219012077 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 483219012078 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 483219012079 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 483219012080 putative homodimer interface [polypeptide binding]; other site 483219012081 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 483219012082 heterodimer interface [polypeptide binding]; other site 483219012083 homodimer interface [polypeptide binding]; other site 483219012084 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 483219012085 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 483219012086 23S rRNA interface [nucleotide binding]; other site 483219012087 L7/L12 interface [polypeptide binding]; other site 483219012088 putative thiostrepton binding site; other site 483219012089 L25 interface [polypeptide binding]; other site 483219012090 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 483219012091 mRNA/rRNA interface [nucleotide binding]; other site 483219012092 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 483219012093 23S rRNA interface [nucleotide binding]; other site 483219012094 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 483219012095 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 483219012096 core dimer interface [polypeptide binding]; other site 483219012097 peripheral dimer interface [polypeptide binding]; other site 483219012098 L10 interface [polypeptide binding]; other site 483219012099 L11 interface [polypeptide binding]; other site 483219012100 putative EF-Tu interaction site [polypeptide binding]; other site 483219012101 putative EF-G interaction site [polypeptide binding]; other site 483219012102 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 483219012103 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 483219012104 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 483219012105 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 483219012106 RPB11 interaction site [polypeptide binding]; other site 483219012107 RPB12 interaction site [polypeptide binding]; other site 483219012108 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 483219012109 RPB3 interaction site [polypeptide binding]; other site 483219012110 RPB1 interaction site [polypeptide binding]; other site 483219012111 RPB11 interaction site [polypeptide binding]; other site 483219012112 RPB10 interaction site [polypeptide binding]; other site 483219012113 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 483219012114 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 483219012115 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 483219012116 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 483219012117 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 483219012118 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 483219012119 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 483219012120 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 483219012121 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 483219012122 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 483219012123 DNA binding site [nucleotide binding] 483219012124 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 483219012125 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 483219012126 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 483219012127 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 483219012128 N-acetyl-D-glucosamine binding site [chemical binding]; other site 483219012129 catalytic residue [active] 483219012130 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219012131 TPR repeat; Region: TPR_11; pfam13414 483219012132 binding surface 483219012133 TPR motif; other site 483219012134 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219012135 binding surface 483219012136 TPR motif; other site 483219012137 Tetratricopeptide repeat; Region: TPR_12; pfam13424 483219012138 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219012139 binding surface 483219012140 TPR motif; other site 483219012141 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 483219012142 non-specific DNA binding site [nucleotide binding]; other site 483219012143 salt bridge; other site 483219012144 sequence-specific DNA binding site [nucleotide binding]; other site 483219012145 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 483219012146 Recombination protein O N terminal; Region: RecO_N; pfam11967 483219012147 Recombination protein O C terminal; Region: RecO_C; pfam02565 483219012148 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 483219012149 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 483219012150 putative substrate binding site [chemical binding]; other site 483219012151 putative ATP binding site [chemical binding]; other site 483219012152 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 483219012153 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 483219012154 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 483219012155 DNA binding residues [nucleotide binding] 483219012156 dimer interface [polypeptide binding]; other site 483219012157 oligopeptide transporter, OPT superfamily; Region: OPT_sfam; TIGR00728 483219012158 OPT oligopeptide transporter protein; Region: OPT; cl14607 483219012159 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219012160 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219012161 active site 483219012162 ATP binding site [chemical binding]; other site 483219012163 substrate binding site [chemical binding]; other site 483219012164 activation loop (A-loop); other site 483219012165 Tetratricopeptide repeat; Region: TPR_12; pfam13424 483219012166 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219012167 binding surface 483219012168 TPR motif; other site 483219012169 Tetratricopeptide repeat; Region: TPR_12; pfam13424 483219012170 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219012171 active site 483219012172 ATP binding site [chemical binding]; other site 483219012173 substrate binding site [chemical binding]; other site 483219012174 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219012175 activation loop (A-loop); other site 483219012176 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 483219012177 phosphopeptide binding site; other site 483219012178 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 483219012179 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219012180 Walker A motif; other site 483219012181 ATP binding site [chemical binding]; other site 483219012182 Walker B motif; other site 483219012183 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 483219012184 Protein of unknown function (DUF419); Region: DUF419; cl15265 483219012185 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 483219012186 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 483219012187 ligand binding site [chemical binding]; other site 483219012188 flexible hinge region; other site 483219012189 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 483219012190 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219012191 putative active site [active] 483219012192 heme pocket [chemical binding]; other site 483219012193 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219012194 dimer interface [polypeptide binding]; other site 483219012195 phosphorylation site [posttranslational modification] 483219012196 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219012197 ATP binding site [chemical binding]; other site 483219012198 Mg2+ binding site [ion binding]; other site 483219012199 G-X-G motif; other site 483219012200 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219012201 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219012202 active site 483219012203 ATP binding site [chemical binding]; other site 483219012204 substrate binding site [chemical binding]; other site 483219012205 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 483219012206 substrate binding site [chemical binding]; other site 483219012207 activation loop (A-loop); other site 483219012208 activation loop (A-loop); other site 483219012209 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 483219012210 dimer interface [polypeptide binding]; other site 483219012211 motif 1; other site 483219012212 active site 483219012213 motif 2; other site 483219012214 motif 3; other site 483219012215 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 483219012216 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 483219012217 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 483219012218 phosphopeptide binding site; other site 483219012219 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 483219012220 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 483219012221 phosphopeptide binding site; other site 483219012222 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 483219012223 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 483219012224 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 483219012225 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 483219012226 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 483219012227 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 483219012228 phosphopeptide binding site; other site 483219012229 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 483219012230 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 483219012231 ATP binding site [chemical binding]; other site 483219012232 Walker A motif; other site 483219012233 hexamer interface [polypeptide binding]; other site 483219012234 Walker B motif; other site 483219012235 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 483219012236 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 483219012237 phosphopeptide binding site; other site 483219012238 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 483219012239 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 483219012240 phosphopeptide binding site; other site 483219012241 DNA polymerase I; Provisional; Region: PRK05755 483219012242 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 483219012243 active site 483219012244 metal binding site 1 [ion binding]; metal-binding site 483219012245 putative 5' ssDNA interaction site; other site 483219012246 metal binding site 3; metal-binding site 483219012247 metal binding site 2 [ion binding]; metal-binding site 483219012248 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 483219012249 putative DNA binding site [nucleotide binding]; other site 483219012250 putative metal binding site [ion binding]; other site 483219012251 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 483219012252 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 483219012253 active site 483219012254 DNA binding site [nucleotide binding] 483219012255 catalytic site [active] 483219012256 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 483219012257 DivIVA protein; Region: DivIVA; pfam05103 483219012258 DivIVA domain; Region: DivI1A_domain; TIGR03544 483219012259 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 483219012260 HSP70 interaction site [polypeptide binding]; other site 483219012261 Integral membrane protein DUF95; Region: DUF95; pfam01944 483219012262 RDD family; Region: RDD; pfam06271 483219012263 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 483219012264 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219012265 active site 483219012266 phosphorylation site [posttranslational modification] 483219012267 intermolecular recognition site; other site 483219012268 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 483219012269 DNA binding residues [nucleotide binding] 483219012270 dimerization interface [polypeptide binding]; other site 483219012271 MbtH-like protein; Region: MbtH; cl01279 483219012272 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 483219012273 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 483219012274 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 483219012275 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 483219012276 TIR domain; Region: TIR_2; cl17458 483219012277 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820 483219012278 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 483219012279 dimer interface [polypeptide binding]; other site 483219012280 active site 483219012281 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 483219012282 substrate binding site [chemical binding]; other site 483219012283 catalytic residue [active] 483219012284 Predicted lipoprotein of unknown function (DUF2380); Region: DUF2380; cl15289 483219012285 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 483219012286 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 483219012287 Walker A/P-loop; other site 483219012288 ATP binding site [chemical binding]; other site 483219012289 ABC transporter; Region: ABC_tran; pfam00005 483219012290 Q-loop/lid; other site 483219012291 ABC transporter signature motif; other site 483219012292 Walker B; other site 483219012293 D-loop; other site 483219012294 H-loop/switch region; other site 483219012295 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 483219012296 Domain of unknown function (DUF3526); Region: DUF3526; pfam12040 483219012297 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 483219012298 Domain of unknown function (DUF3526); Region: DUF3526; pfam12040 483219012299 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 483219012300 Protein of unknown function, DUF488; Region: DUF488; pfam04343 483219012301 PGAP1-like protein; Region: PGAP1; pfam07819 483219012302 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 483219012303 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 483219012304 active site 483219012305 catalytic tetrad [active] 483219012306 Transcriptional regulator [Transcription]; Region: LysR; COG0583 483219012307 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 483219012308 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 483219012309 putative effector binding pocket; other site 483219012310 putative dimerization interface [polypeptide binding]; other site 483219012311 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 483219012312 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 483219012313 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 483219012314 Putative exonuclease, RdgC; Region: RdgC; cl01122 483219012315 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 483219012316 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219012317 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219012318 dimer interface [polypeptide binding]; other site 483219012319 phosphorylation site [posttranslational modification] 483219012320 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219012321 ATP binding site [chemical binding]; other site 483219012322 Mg2+ binding site [ion binding]; other site 483219012323 G-X-G motif; other site 483219012324 Response regulator receiver domain; Region: Response_reg; pfam00072 483219012325 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219012326 active site 483219012327 phosphorylation site [posttranslational modification] 483219012328 intermolecular recognition site; other site 483219012329 dimerization interface [polypeptide binding]; other site 483219012330 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 483219012331 conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806 483219012332 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 483219012333 putative catalytic site [active] 483219012334 putative metal binding site [ion binding]; other site 483219012335 putative phosphate binding site [ion binding]; other site 483219012336 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 483219012337 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 483219012338 xanthine dehydrogenase; Region: PLN02906 483219012339 catalytic loop [active] 483219012340 iron binding site [ion binding]; other site 483219012341 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 483219012342 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 483219012343 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 483219012344 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 483219012345 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 483219012346 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 483219012347 XdhC Rossmann domain; Region: XdhC_C; pfam13478 483219012348 spore photoproduct lyase family protein; Region: lyase_spl_fam; TIGR03886 483219012349 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 483219012350 Predicted membrane protein [Function unknown]; Region: COG2311 483219012351 Protein of unknown function (DUF418); Region: DUF418; pfam04235 483219012352 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 483219012353 nucleophilic elbow; other site 483219012354 catalytic triad; other site 483219012355 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 483219012356 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 483219012357 minor groove reading motif; other site 483219012358 helix-hairpin-helix signature motif; other site 483219012359 substrate binding pocket [chemical binding]; other site 483219012360 active site 483219012361 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 483219012362 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 483219012363 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 483219012364 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 483219012365 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 483219012366 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 483219012367 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762 483219012368 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 483219012369 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 483219012370 substrate binding site [chemical binding]; other site 483219012371 oxyanion hole (OAH) forming residues; other site 483219012372 trimer interface [polypeptide binding]; other site 483219012373 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 483219012374 Haemolysin-III related; Region: HlyIII; pfam03006 483219012375 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 483219012376 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 483219012377 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 483219012378 active site 483219012379 Zn binding site [ion binding]; other site 483219012380 fumarate hydratase; Provisional; Region: PRK15389 483219012381 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 483219012382 Fumarase C-terminus; Region: Fumerase_C; pfam05683 483219012383 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 483219012384 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 483219012385 ligand binding site [chemical binding]; other site 483219012386 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 483219012387 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 483219012388 Response regulator receiver domain; Region: Response_reg; pfam00072 483219012389 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219012390 active site 483219012391 phosphorylation site [posttranslational modification] 483219012392 intermolecular recognition site; other site 483219012393 dimerization interface [polypeptide binding]; other site 483219012394 RecA-superfamily ATPases implicated in signal transduction [Signal transduction mechanisms]; Region: RAD55; COG0467 483219012395 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 483219012396 Walker A motif; other site 483219012397 ATP binding site [chemical binding]; other site 483219012398 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 483219012399 KaiC; Region: KaiC; pfam06745 483219012400 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 483219012401 ATP binding site [chemical binding]; other site 483219012402 Walker B motif; other site 483219012403 Response regulator receiver domain; Region: Response_reg; pfam00072 483219012404 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219012405 active site 483219012406 phosphorylation site [posttranslational modification] 483219012407 intermolecular recognition site; other site 483219012408 dimerization interface [polypeptide binding]; other site 483219012409 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219012410 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219012411 dimer interface [polypeptide binding]; other site 483219012412 phosphorylation site [posttranslational modification] 483219012413 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219012414 ATP binding site [chemical binding]; other site 483219012415 Mg2+ binding site [ion binding]; other site 483219012416 G-X-G motif; other site 483219012417 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241 483219012418 putative active site [active] 483219012419 Zn binding site [ion binding]; other site 483219012420 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 483219012421 HSP70 interaction site [polypeptide binding]; other site 483219012422 Protein of unknown function (DUF808); Region: DUF808; pfam05661 483219012423 Prostaglandin dehydrogenases; Region: PGDH; cd05288 483219012424 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 483219012425 NAD(P) binding site [chemical binding]; other site 483219012426 substrate binding site [chemical binding]; other site 483219012427 dimer interface [polypeptide binding]; other site 483219012428 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 483219012429 HflK protein; Region: hflK; TIGR01933 483219012430 HflC protein; Region: hflC; TIGR01932 483219012431 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 483219012432 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 483219012433 putative catalytic site [active] 483219012434 putative metal binding site [ion binding]; other site 483219012435 putative phosphate binding site [ion binding]; other site 483219012436 Superfamily II helicase, archaea-specific [General function prediction only]; Region: COG1202 483219012437 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 483219012438 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 483219012439 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 483219012440 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 483219012441 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 483219012442 putative active site [active] 483219012443 PhoH-like protein; Region: PhoH; pfam02562 483219012444 Protein of unknown function (DUF493); Region: DUF493; pfam04359 483219012445 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 483219012446 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 483219012447 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 483219012448 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 483219012449 nucleotide binding site [chemical binding]; other site 483219012450 NEF interaction site [polypeptide binding]; other site 483219012451 SBD interface [polypeptide binding]; other site 483219012452 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 483219012453 Protein of unknown function, DUF393; Region: DUF393; pfam04134 483219012454 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219012455 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 483219012456 Walker A motif; other site 483219012457 ATP binding site [chemical binding]; other site 483219012458 Walker B motif; other site 483219012459 arginine finger; other site 483219012460 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 483219012461 metal ion-dependent adhesion site (MIDAS); other site 483219012462 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 483219012463 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 483219012464 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 483219012465 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 483219012466 phosphopeptide binding site; other site 483219012467 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 483219012468 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219012469 active site 483219012470 ATP binding site [chemical binding]; other site 483219012471 substrate binding site [chemical binding]; other site 483219012472 activation loop (A-loop); other site 483219012473 FHA domain; Region: FHA; pfam00498 483219012474 phosphopeptide binding site; other site 483219012475 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 483219012476 phosphopeptide binding site; other site 483219012477 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 483219012478 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 483219012479 Zn2+ binding site [ion binding]; other site 483219012480 Mg2+ binding site [ion binding]; other site 483219012481 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 483219012482 synthetase active site [active] 483219012483 NTP binding site [chemical binding]; other site 483219012484 metal binding site [ion binding]; metal-binding site 483219012485 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 483219012486 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 483219012487 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 483219012488 homotrimer interaction site [polypeptide binding]; other site 483219012489 putative active site [active] 483219012490 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 483219012491 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 483219012492 Thioredoxin; Region: Thioredoxin_4; pfam13462 483219012493 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 483219012494 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 483219012495 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 483219012496 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 483219012497 CPxP motif; other site 483219012498 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 483219012499 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 483219012500 Walker A/P-loop; other site 483219012501 ATP binding site [chemical binding]; other site 483219012502 Q-loop/lid; other site 483219012503 ABC transporter signature motif; other site 483219012504 Walker B; other site 483219012505 D-loop; other site 483219012506 H-loop/switch region; other site 483219012507 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 483219012508 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 483219012509 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 483219012510 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 483219012511 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 483219012512 active site 483219012513 phosphorylation site [posttranslational modification] 483219012514 intermolecular recognition site; other site 483219012515 dimerization interface [polypeptide binding]; other site 483219012516 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 483219012517 metal binding site [ion binding]; metal-binding site 483219012518 active site 483219012519 I-site; other site 483219012520 Response regulator receiver domain; Region: Response_reg; pfam00072 483219012521 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219012522 active site 483219012523 phosphorylation site [posttranslational modification] 483219012524 intermolecular recognition site; other site 483219012525 dimerization interface [polypeptide binding]; other site 483219012526 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219012527 Walker A motif; other site 483219012528 ATP binding site [chemical binding]; other site 483219012529 Walker B motif; other site 483219012530 arginine finger; other site 483219012531 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 483219012532 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 483219012533 putative NAD(P) binding site [chemical binding]; other site 483219012534 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 483219012535 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 483219012536 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 483219012537 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 483219012538 Coenzyme A binding pocket [chemical binding]; other site 483219012539 flagellin; Provisional; Region: PRK12806 483219012540 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219012541 binding surface 483219012542 TPR repeat; Region: TPR_11; pfam13414 483219012543 TPR motif; other site 483219012544 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 483219012545 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 483219012546 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 483219012547 Prephenate dehydratase; Region: PDT; pfam00800 483219012548 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 483219012549 putative L-Phe binding site [chemical binding]; other site 483219012550 Chorismate mutase type II; Region: CM_2; smart00830 483219012551 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 483219012552 Prephenate dehydratase; Region: PDT; pfam00800 483219012553 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 483219012554 putative L-Phe binding site [chemical binding]; other site 483219012555 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 483219012556 EVE domain; Region: EVE; pfam01878 483219012557 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 483219012558 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 483219012559 SLBB domain; Region: SLBB; pfam10531 483219012560 Chain length determinant protein; Region: Wzz; pfam02706 483219012561 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 483219012562 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 483219012563 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 483219012564 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 483219012565 Bacterial sugar transferase; Region: Bac_transf; pfam02397 483219012566 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 483219012567 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 483219012568 phosphate binding site [ion binding]; other site 483219012569 putative substrate binding pocket [chemical binding]; other site 483219012570 dimer interface [polypeptide binding]; other site 483219012571 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 483219012572 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 483219012573 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 483219012574 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 483219012575 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 483219012576 catalytic residue [active] 483219012577 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 483219012578 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 483219012579 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219012580 TPR motif; other site 483219012581 binding surface 483219012582 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 483219012583 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 483219012584 Phosphotransferase enzyme family; Region: APH; pfam01636 483219012585 putative active site [active] 483219012586 putative substrate binding site [chemical binding]; other site 483219012587 ATP binding site [chemical binding]; other site 483219012588 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 483219012589 Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751 483219012590 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 483219012591 Transcriptional regulators [Transcription]; Region: MarR; COG1846 483219012592 MarR family; Region: MarR_2; pfam12802 483219012593 Protein of unknown function (DUF1428); Region: DUF1428; pfam07237 483219012594 Protein of unknown function (DUF1428); Region: DUF1428; pfam07237 483219012595 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 483219012596 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 483219012597 putative active site [active] 483219012598 putative FMN binding site [chemical binding]; other site 483219012599 putative substrate binding site [chemical binding]; other site 483219012600 putative catalytic residue [active] 483219012601 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 483219012602 Domain of unknown function (DUF4135); Region: DUF4135; pfam13575 483219012603 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 483219012604 active site 483219012605 zinc binding site [ion binding]; other site 483219012606 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 483219012607 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219012608 Walker A/P-loop; other site 483219012609 ATP binding site [chemical binding]; other site 483219012610 Q-loop/lid; other site 483219012611 ABC transporter signature motif; other site 483219012612 Walker B; other site 483219012613 D-loop; other site 483219012614 H-loop/switch region; other site 483219012615 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 483219012616 FAD binding domain; Region: FAD_binding_4; pfam01565 483219012617 Berberine and berberine like; Region: BBE; pfam08031 483219012618 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 483219012619 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 483219012620 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 483219012621 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 483219012622 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 483219012623 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 483219012624 CcmE; Region: CcmE; pfam03100 483219012625 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 483219012626 CcmB protein; Region: CcmB; cl17444 483219012627 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 483219012628 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219012629 Walker A/P-loop; other site 483219012630 ATP binding site [chemical binding]; other site 483219012631 Q-loop/lid; other site 483219012632 ABC transporter signature motif; other site 483219012633 Walker B; other site 483219012634 D-loop; other site 483219012635 H-loop/switch region; other site 483219012636 Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969 483219012637 putative active site [active] 483219012638 putative metal binding site [ion binding]; other site 483219012639 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 483219012640 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 483219012641 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 483219012642 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 483219012643 active site 483219012644 substrate binding site [chemical binding]; other site 483219012645 CoA binding site [chemical binding]; other site 483219012646 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 483219012647 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 483219012648 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 483219012649 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 483219012650 putative homodimer interface [polypeptide binding]; other site 483219012651 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 483219012652 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 483219012653 thiamine phosphate binding site [chemical binding]; other site 483219012654 active site 483219012655 pyrophosphate binding site [ion binding]; other site 483219012656 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 483219012657 ThiS interaction site; other site 483219012658 putative active site [active] 483219012659 tetramer interface [polypeptide binding]; other site 483219012660 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 483219012661 thiS-thiF/thiG interaction site; other site 483219012662 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219012663 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219012664 active site 483219012665 substrate binding site [chemical binding]; other site 483219012666 ATP binding site [chemical binding]; other site 483219012667 activation loop (A-loop); other site 483219012668 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 483219012669 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 483219012670 active site 483219012671 dimer interface [polypeptide binding]; other site 483219012672 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 483219012673 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 483219012674 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 483219012675 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 483219012676 TAP-like protein; Region: Abhydrolase_4; pfam08386 483219012677 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 483219012678 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 483219012679 oligomer interface [polypeptide binding]; other site 483219012680 metal binding site [ion binding]; metal-binding site 483219012681 metal binding site [ion binding]; metal-binding site 483219012682 putative Cl binding site [ion binding]; other site 483219012683 aspartate ring; other site 483219012684 basic sphincter; other site 483219012685 hydrophobic gate; other site 483219012686 periplasmic entrance; other site 483219012687 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 483219012688 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 483219012689 active site 483219012690 motif I; other site 483219012691 motif II; other site 483219012692 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 483219012693 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 483219012694 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 483219012695 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 483219012696 putative RNA binding site [nucleotide binding]; other site 483219012697 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219012698 S-adenosylmethionine binding site [chemical binding]; other site 483219012699 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 483219012700 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 483219012701 active site 483219012702 catalytic triad [active] 483219012703 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 483219012704 CAAX protease self-immunity; Region: Abi; pfam02517 483219012705 glycerol-3-phosphate acyltransferase; Reviewed; Region: PRK11915 483219012706 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 483219012707 putative acyl-acceptor binding pocket; other site 483219012708 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 483219012709 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 483219012710 active site 483219012711 HIGH motif; other site 483219012712 KMSK motif region; other site 483219012713 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 483219012714 tRNA binding surface [nucleotide binding]; other site 483219012715 anticodon binding site; other site 483219012716 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219012717 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219012718 dimer interface [polypeptide binding]; other site 483219012719 phosphorylation site [posttranslational modification] 483219012720 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219012721 ATP binding site [chemical binding]; other site 483219012722 Mg2+ binding site [ion binding]; other site 483219012723 G-X-G motif; other site 483219012724 Response regulator receiver domain; Region: Response_reg; pfam00072 483219012725 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219012726 active site 483219012727 phosphorylation site [posttranslational modification] 483219012728 intermolecular recognition site; other site 483219012729 dimerization interface [polypeptide binding]; other site 483219012730 HEAT repeats; Region: HEAT_2; pfam13646 483219012731 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 483219012732 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 483219012733 HSP70 interaction site [polypeptide binding]; other site 483219012734 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 483219012735 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 483219012736 Zn binding sites [ion binding]; other site 483219012737 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 483219012738 dimer interface [polypeptide binding]; other site 483219012739 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 483219012740 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 483219012741 Coenzyme A binding pocket [chemical binding]; other site 483219012742 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 483219012743 S17 interaction site [polypeptide binding]; other site 483219012744 S8 interaction site; other site 483219012745 16S rRNA interaction site [nucleotide binding]; other site 483219012746 streptomycin interaction site [chemical binding]; other site 483219012747 23S rRNA interaction site [nucleotide binding]; other site 483219012748 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 483219012749 30S ribosomal protein S7; Validated; Region: PRK05302 483219012750 elongation factor G; Reviewed; Region: PRK00007 483219012751 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 483219012752 G1 box; other site 483219012753 putative GEF interaction site [polypeptide binding]; other site 483219012754 GTP/Mg2+ binding site [chemical binding]; other site 483219012755 Switch I region; other site 483219012756 G2 box; other site 483219012757 G3 box; other site 483219012758 Switch II region; other site 483219012759 G4 box; other site 483219012760 G5 box; other site 483219012761 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 483219012762 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 483219012763 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 483219012764 elongation factor Tu; Reviewed; Region: PRK00049 483219012765 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 483219012766 G1 box; other site 483219012767 GEF interaction site [polypeptide binding]; other site 483219012768 GTP/Mg2+ binding site [chemical binding]; other site 483219012769 Switch I region; other site 483219012770 G2 box; other site 483219012771 G3 box; other site 483219012772 Switch II region; other site 483219012773 G4 box; other site 483219012774 G5 box; other site 483219012775 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 483219012776 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 483219012777 Antibiotic Binding Site [chemical binding]; other site 483219012778 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 483219012779 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 483219012780 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 483219012781 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 483219012782 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 483219012783 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 483219012784 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 483219012785 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 483219012786 putative translocon binding site; other site 483219012787 protein-rRNA interface [nucleotide binding]; other site 483219012788 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 483219012789 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 483219012790 G-X-X-G motif; other site 483219012791 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 483219012792 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 483219012793 23S rRNA interface [nucleotide binding]; other site 483219012794 5S rRNA interface [nucleotide binding]; other site 483219012795 putative antibiotic binding site [chemical binding]; other site 483219012796 L25 interface [polypeptide binding]; other site 483219012797 L27 interface [polypeptide binding]; other site 483219012798 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 483219012799 23S rRNA interface [nucleotide binding]; other site 483219012800 putative translocon interaction site; other site 483219012801 signal recognition particle (SRP54) interaction site; other site 483219012802 L23 interface [polypeptide binding]; other site 483219012803 trigger factor interaction site; other site 483219012804 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 483219012805 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 483219012806 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 483219012807 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 483219012808 RNA binding site [nucleotide binding]; other site 483219012809 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 483219012810 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 483219012811 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 483219012812 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 483219012813 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 483219012814 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 483219012815 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 483219012816 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 483219012817 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 483219012818 5S rRNA interface [nucleotide binding]; other site 483219012819 L27 interface [polypeptide binding]; other site 483219012820 23S rRNA interface [nucleotide binding]; other site 483219012821 L5 interface [polypeptide binding]; other site 483219012822 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 483219012823 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 483219012824 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 483219012825 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 483219012826 23S rRNA binding site [nucleotide binding]; other site 483219012827 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 483219012828 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 483219012829 SecY translocase; Region: SecY; pfam00344 483219012830 adenylate kinase; Reviewed; Region: adk; PRK00279 483219012831 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 483219012832 AMP-binding site [chemical binding]; other site 483219012833 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 483219012834 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 483219012835 rRNA binding site [nucleotide binding]; other site 483219012836 predicted 30S ribosome binding site; other site 483219012837 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 483219012838 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 483219012839 30S ribosomal protein S13; Region: bact_S13; TIGR03631 483219012840 30S ribosomal protein S11; Validated; Region: PRK05309 483219012841 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 483219012842 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 483219012843 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 483219012844 RNA binding surface [nucleotide binding]; other site 483219012845 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 483219012846 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 483219012847 alphaNTD homodimer interface [polypeptide binding]; other site 483219012848 alphaNTD - beta interaction site [polypeptide binding]; other site 483219012849 alphaNTD - beta' interaction site [polypeptide binding]; other site 483219012850 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 483219012851 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 483219012852 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 483219012853 TPR repeat; Region: TPR_11; pfam13414 483219012854 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219012855 TPR motif; other site 483219012856 binding surface 483219012857 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219012858 TPR motif; other site 483219012859 TPR repeat; Region: TPR_11; pfam13414 483219012860 binding surface 483219012861 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219012862 binding surface 483219012863 TPR motif; other site 483219012864 TPR repeat; Region: TPR_11; pfam13414 483219012865 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 483219012866 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 483219012867 putative acyl-acceptor binding pocket; other site 483219012868 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 483219012869 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 483219012870 Substrate-binding site [chemical binding]; other site 483219012871 Substrate specificity [chemical binding]; other site 483219012872 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 483219012873 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 483219012874 phosphopeptide binding site; other site 483219012875 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 483219012876 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219012877 Walker A motif; other site 483219012878 ATP binding site [chemical binding]; other site 483219012879 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 483219012880 EamA-like transporter family; Region: EamA; pfam00892 483219012881 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 483219012882 EamA-like transporter family; Region: EamA; pfam00892 483219012883 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 483219012884 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 483219012885 NAD-dependent deacetylase; Provisional; Region: PRK00481 483219012886 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 483219012887 NAD+ binding site [chemical binding]; other site 483219012888 substrate binding site [chemical binding]; other site 483219012889 Zn binding site [ion binding]; other site 483219012890 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219012891 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219012892 active site 483219012893 ATP binding site [chemical binding]; other site 483219012894 substrate binding site [chemical binding]; other site 483219012895 activation loop (A-loop); other site 483219012896 PEGA domain; Region: PEGA; pfam08308 483219012897 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 483219012898 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 483219012899 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 483219012900 ABC transporter; Region: ABC_tran_2; pfam12848 483219012901 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 483219012902 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 483219012903 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 483219012904 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 483219012905 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 483219012906 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219012907 phosphorylation site [posttranslational modification] 483219012908 dimer interface [polypeptide binding]; other site 483219012909 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219012910 ATP binding site [chemical binding]; other site 483219012911 Mg2+ binding site [ion binding]; other site 483219012912 G-X-G motif; other site 483219012913 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 483219012914 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 483219012915 N-acetyl-D-glucosamine binding site [chemical binding]; other site 483219012916 catalytic residue [active] 483219012917 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 483219012918 DNA-binding site [nucleotide binding]; DNA binding site 483219012919 RNA-binding motif; other site 483219012920 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 483219012921 L-seryl-tRNA selenium transferase; Region: SelA; pfam03841 483219012922 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 483219012923 catalytic residue [active] 483219012924 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 483219012925 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 483219012926 active site 483219012927 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 483219012928 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 483219012929 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 483219012930 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 483219012931 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 483219012932 HSP70 interaction site [polypeptide binding]; other site 483219012933 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 483219012934 non-specific DNA binding site [nucleotide binding]; other site 483219012935 salt bridge; other site 483219012936 sequence-specific DNA binding site [nucleotide binding]; other site 483219012937 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 483219012938 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 483219012939 RNA binding surface [nucleotide binding]; other site 483219012940 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 483219012941 active site 483219012942 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 483219012943 OPT oligopeptide transporter protein; Region: OPT; cl14607 483219012944 OPT oligopeptide transporter protein; Region: OPT; cl14607 483219012945 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 483219012946 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 483219012947 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 483219012948 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 483219012949 DNA binding residues [nucleotide binding] 483219012950 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 483219012951 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 483219012952 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 483219012953 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 483219012954 Protein of unknown function DUF58; Region: DUF58; pfam01882 483219012955 MoxR-like ATPases [General function prediction only]; Region: COG0714 483219012956 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 483219012957 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219012958 Walker A motif; other site 483219012959 ATP binding site [chemical binding]; other site 483219012960 Walker B motif; other site 483219012961 arginine finger; other site 483219012962 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 483219012963 anti sigma factor interaction site; other site 483219012964 regulatory phosphorylation site [posttranslational modification]; other site 483219012965 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 483219012966 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 483219012967 N-acetyl-D-glucosamine binding site [chemical binding]; other site 483219012968 catalytic residue [active] 483219012969 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 483219012970 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 483219012971 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 483219012972 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 483219012973 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219012974 TPR motif; other site 483219012975 binding surface 483219012976 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219012977 TPR motif; other site 483219012978 Tetratricopeptide repeat; Region: TPR_12; pfam13424 483219012979 binding surface 483219012980 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219012981 binding surface 483219012982 Tetratricopeptide repeat; Region: TPR_12; pfam13424 483219012983 TPR motif; other site 483219012984 TPR repeat; Region: TPR_11; pfam13414 483219012985 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219012986 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 483219012987 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 483219012988 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 483219012989 G1 box; other site 483219012990 putative GEF interaction site [polypeptide binding]; other site 483219012991 GTP/Mg2+ binding site [chemical binding]; other site 483219012992 Switch I region; other site 483219012993 G2 box; other site 483219012994 G3 box; other site 483219012995 Switch II region; other site 483219012996 G4 box; other site 483219012997 G5 box; other site 483219012998 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 483219012999 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 483219013000 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 483219013001 TAP-like protein; Region: Abhydrolase_4; pfam08386 483219013002 Sensory domain found in PocR; Region: PocR; pfam10114 483219013003 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 483219013004 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219013005 Walker A motif; other site 483219013006 ATP binding site [chemical binding]; other site 483219013007 Walker B motif; other site 483219013008 arginine finger; other site 483219013009 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 483219013010 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 483219013011 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 483219013012 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219013013 S-adenosylmethionine binding site [chemical binding]; other site 483219013014 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 483219013015 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 483219013016 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 483219013017 active site 483219013018 (T/H)XGH motif; other site 483219013019 aspartate aminotransferase; Provisional; Region: PRK05764 483219013020 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 483219013021 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483219013022 homodimer interface [polypeptide binding]; other site 483219013023 catalytic residue [active] 483219013024 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 483219013025 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 483219013026 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 483219013027 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 483219013028 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 483219013029 ATP-grasp domain; Region: ATP-grasp_4; cl17255 483219013030 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 483219013031 IMP binding site; other site 483219013032 dimer interface [polypeptide binding]; other site 483219013033 interdomain contacts; other site 483219013034 partial ornithine binding site; other site 483219013035 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 483219013036 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 483219013037 active site 483219013038 FMN binding site [chemical binding]; other site 483219013039 substrate binding site [chemical binding]; other site 483219013040 putative catalytic residue [active] 483219013041 Fatty acid desaturase; Region: FA_desaturase; pfam00487 483219013042 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 483219013043 putative di-iron ligands [ion binding]; other site 483219013044 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 483219013045 putative hydrophobic ligand binding site [chemical binding]; other site 483219013046 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 483219013047 dinuclear metal binding motif [ion binding]; other site 483219013048 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 483219013049 active site 483219013050 catalytic residues [active] 483219013051 metal binding site [ion binding]; metal-binding site 483219013052 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 483219013053 CoenzymeA binding site [chemical binding]; other site 483219013054 subunit interaction site [polypeptide binding]; other site 483219013055 PHB binding site; other site 483219013056 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 483219013057 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 483219013058 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 483219013059 substrate binding pocket [chemical binding]; other site 483219013060 membrane-bound complex binding site; other site 483219013061 hinge residues; other site 483219013062 Predicted soluble lytic transglycosylase fused to an ABC-type amino acid-binding protein [Cell envelope biogenesis, outer membrane]; Region: COG4623 483219013063 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 483219013064 substrate binding pocket [chemical binding]; other site 483219013065 membrane-bound complex binding site; other site 483219013066 hinge residues; other site 483219013067 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 483219013068 N-acetyl-D-glucosamine binding site [chemical binding]; other site 483219013069 catalytic residue [active] 483219013070 hypothetical protein; Provisional; Region: PRK06753 483219013071 hypothetical protein; Provisional; Region: PRK07236 483219013072 conserved hypothetical protein; Region: TIGR02231 483219013073 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 483219013074 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 483219013075 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 483219013076 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 483219013077 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 483219013078 DNA binding site [nucleotide binding] 483219013079 active site 483219013080 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 483219013081 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 483219013082 phosphopeptide binding site; other site 483219013083 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 483219013084 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 483219013085 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 483219013086 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 483219013087 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 483219013088 ssDNA binding site; other site 483219013089 generic binding surface II; other site 483219013090 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 483219013091 ATP binding site [chemical binding]; other site 483219013092 putative Mg++ binding site [ion binding]; other site 483219013093 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 483219013094 nucleotide binding region [chemical binding]; other site 483219013095 ATP-binding site [chemical binding]; other site 483219013096 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 483219013097 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219013098 S-adenosylmethionine binding site [chemical binding]; other site 483219013099 threonine synthase; Validated; Region: PRK06260 483219013100 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 483219013101 homodimer interface [polypeptide binding]; other site 483219013102 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483219013103 catalytic residue [active] 483219013104 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 483219013105 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 483219013106 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 483219013107 dimerization interface [polypeptide binding]; other site 483219013108 active site 483219013109 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 483219013110 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 483219013111 TMP-binding site; other site 483219013112 ATP-binding site [chemical binding]; other site 483219013113 Predicted membrane protein [Function unknown]; Region: COG3059 483219013114 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 483219013115 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 483219013116 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 483219013117 Sulfate transporter family; Region: Sulfate_transp; pfam00916 483219013118 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 483219013119 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 483219013120 active site residue [active] 483219013121 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 483219013122 Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411 483219013123 active site 483219013124 metal binding site [ion binding]; metal-binding site 483219013125 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 483219013126 Predicted membrane protein [Function unknown]; Region: COG2855 483219013127 DsrE/DsrF-like family; Region: DrsE; pfam02635 483219013128 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 483219013129 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 483219013130 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 483219013131 potential frameshift: common BLAST hit: gi|310817711|ref|YP_003950069.1| peptidase m28 483219013132 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 483219013133 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 483219013134 MPT binding site; other site 483219013135 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219013136 binding surface 483219013137 TPR motif; other site 483219013138 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219013139 binding surface 483219013140 TPR motif; other site 483219013141 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 483219013142 active site 483219013143 CoA binding site [chemical binding]; other site 483219013144 AMP binding site [chemical binding]; other site 483219013145 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219013146 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 483219013147 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219013148 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 483219013149 acyl-activating enzyme (AAE) consensus motif; other site 483219013150 AMP binding site [chemical binding]; other site 483219013151 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219013152 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 483219013153 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 483219013154 acyl-activating enzyme (AAE) consensus motif; other site 483219013155 AMP binding site [chemical binding]; other site 483219013156 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219013157 Condensation domain; Region: Condensation; pfam00668 483219013158 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219013159 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219013160 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 483219013161 acyl-activating enzyme (AAE) consensus motif; other site 483219013162 AMP binding site [chemical binding]; other site 483219013163 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219013164 Condensation domain; Region: Condensation; pfam00668 483219013165 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219013166 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219013167 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 483219013168 acyl-activating enzyme (AAE) consensus motif; other site 483219013169 AMP binding site [chemical binding]; other site 483219013170 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 483219013171 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 483219013172 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 483219013173 active site 483219013174 Zn binding site [ion binding]; other site 483219013175 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 483219013176 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 483219013177 iron-sulfur cluster [ion binding]; other site 483219013178 [2Fe-2S] cluster binding site [ion binding]; other site 483219013179 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 483219013180 hydrophobic ligand binding site; other site 483219013181 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 483219013182 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 483219013183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483219013184 Major Facilitator Superfamily; Region: MFS_1; pfam07690 483219013185 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483219013186 OpgC protein; Region: OpgC_C; cl17858 483219013187 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 483219013188 HlyD family secretion protein; Region: HlyD_3; pfam13437 483219013189 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 483219013190 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 483219013191 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219013192 active site 483219013193 phosphorylation site [posttranslational modification] 483219013194 intermolecular recognition site; other site 483219013195 dimerization interface [polypeptide binding]; other site 483219013196 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 483219013197 DNA binding site [nucleotide binding] 483219013198 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219013199 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 483219013200 dimer interface [polypeptide binding]; other site 483219013201 phosphorylation site [posttranslational modification] 483219013202 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219013203 ATP binding site [chemical binding]; other site 483219013204 Mg2+ binding site [ion binding]; other site 483219013205 G-X-G motif; other site 483219013206 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 483219013207 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 483219013208 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 483219013209 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219013210 Walker A/P-loop; other site 483219013211 ATP binding site [chemical binding]; other site 483219013212 Q-loop/lid; other site 483219013213 ABC transporter signature motif; other site 483219013214 Walker B; other site 483219013215 D-loop; other site 483219013216 H-loop/switch region; other site 483219013217 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 483219013218 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 483219013219 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 483219013220 dimer interface [polypeptide binding]; other site 483219013221 putative CheW interface [polypeptide binding]; other site 483219013222 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 483219013223 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 483219013224 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 483219013225 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 483219013226 catalytic site [active] 483219013227 active site 483219013228 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 483219013229 Uncharacterized conserved protein [Function unknown]; Region: COG3791 483219013230 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 483219013231 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 483219013232 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 483219013233 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 483219013234 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 483219013235 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 483219013236 putative NAD(P) binding site [chemical binding]; other site 483219013237 active site 483219013238 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 483219013239 active site 483219013240 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 483219013241 Acyl transferase domain; Region: Acyl_transf_1; cl08282 483219013242 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 483219013243 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 483219013244 active site 483219013245 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 483219013246 NAD(P) binding site [chemical binding]; other site 483219013247 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 483219013248 active site 483219013249 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 483219013250 Fatty acid desaturase; Region: FA_desaturase; pfam00487 483219013251 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 483219013252 putative di-iron ligands [ion binding]; other site 483219013253 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 483219013254 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219013255 Methyltransferase domain; Region: Methyltransf_31; pfam13847 483219013256 S-adenosylmethionine binding site [chemical binding]; other site 483219013257 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 483219013258 active sites [active] 483219013259 tetramer interface [polypeptide binding]; other site 483219013260 aspartate kinase; Reviewed; Region: PRK06635 483219013261 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 483219013262 putative catalytic residues [active] 483219013263 putative nucleotide binding site [chemical binding]; other site 483219013264 putative aspartate binding site [chemical binding]; other site 483219013265 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 483219013266 putative allosteric regulatory site; other site 483219013267 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 483219013268 putative allosteric regulatory residue; other site 483219013269 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 483219013270 CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439 483219013271 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 483219013272 DXD motif; other site 483219013273 CHAP domain; Region: CHAP; cl17642 483219013274 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 483219013275 Part of AAA domain; Region: AAA_19; pfam13245 483219013276 Family description; Region: UvrD_C_2; pfam13538 483219013277 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 483219013278 nucleotide binding site [chemical binding]; other site 483219013279 SCP-2 sterol transfer family; Region: SCP2; cl01225 483219013280 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 483219013281 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 483219013282 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 483219013283 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 483219013284 iron-sulfur cluster [ion binding]; other site 483219013285 [2Fe-2S] cluster binding site [ion binding]; other site 483219013286 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 483219013287 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 483219013288 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 483219013289 DXD motif; other site 483219013290 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 483219013291 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 483219013292 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 483219013293 AAA domain; Region: AAA_22; pfam13401 483219013294 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 483219013295 ligand-binding site [chemical binding]; other site 483219013296 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 483219013297 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 483219013298 Predicted membrane protein (DUF2070); Region: DUF2070; pfam09843 483219013299 integrase/recombinase; Provisional; Region: PRK15417 483219013300 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 483219013301 active site 483219013302 catalytic residues [active] 483219013303 DNA binding site [nucleotide binding] 483219013304 Int/Topo IB signature motif; other site 483219013305 Helix-turn-helix domain; Region: HTH_17; pfam12728 483219013306 Phage major tail protein 2; Region: Phage_tail_2; cl11463 483219013307 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 483219013308 Phage capsid family; Region: Phage_capsid; pfam05065 483219013309 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 483219013310 Phage-related protein [Function unknown]; Region: COG4695; cl01923 483219013311 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3567 483219013312 Uncharacterized conserved protein [Function unknown]; Region: COG5323 483219013313 Terminase-like family; Region: Terminase_6; pfam03237 483219013314 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 483219013315 NlpC/P60 family; Region: NLPC_P60; cl17555 483219013316 NgoMIV restriction enzyme; Region: NgoMIV_restric; pfam09015 483219013317 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 483219013318 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 483219013319 cofactor binding site; other site 483219013320 DNA binding site [nucleotide binding] 483219013321 substrate interaction site [chemical binding]; other site 483219013322 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 483219013323 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 483219013324 Fatty acid desaturase; Region: FA_desaturase; pfam00487 483219013325 putative di-iron ligands [ion binding]; other site 483219013326 Bacterial transcriptional activator domain; Region: BTAD; smart01043 483219013327 AAA ATPase domain; Region: AAA_16; pfam13191 483219013328 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 483219013329 active site 483219013330 NTP binding site [chemical binding]; other site 483219013331 metal binding triad [ion binding]; metal-binding site 483219013332 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 483219013333 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 483219013334 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 483219013335 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 483219013336 Ligand Binding Site [chemical binding]; other site 483219013337 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 483219013338 IHF dimer interface [polypeptide binding]; other site 483219013339 IHF - DNA interface [nucleotide binding]; other site 483219013340 Sporulation related domain; Region: SPOR; pfam05036 483219013341 Cupin domain; Region: Cupin_2; cl17218 483219013342 MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to...; Region: MBD; cl00110 483219013343 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 483219013344 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 483219013345 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 483219013346 NAD binding site [chemical binding]; other site 483219013347 putative substrate binding site 2 [chemical binding]; other site 483219013348 putative substrate binding site 1 [chemical binding]; other site 483219013349 active site 483219013350 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 483219013351 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 483219013352 NAD(P) binding site [chemical binding]; other site 483219013353 active site 483219013354 GTP-binding protein LepA; Provisional; Region: PRK05433 483219013355 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 483219013356 G1 box; other site 483219013357 putative GEF interaction site [polypeptide binding]; other site 483219013358 GTP/Mg2+ binding site [chemical binding]; other site 483219013359 Switch I region; other site 483219013360 G2 box; other site 483219013361 G3 box; other site 483219013362 Switch II region; other site 483219013363 G4 box; other site 483219013364 G5 box; other site 483219013365 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 483219013366 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 483219013367 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 483219013368 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 483219013369 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 483219013370 Catalytic site [active] 483219013371 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 483219013372 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 483219013373 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 483219013374 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 483219013375 dihydroorotase; Validated; Region: pyrC; PRK09357 483219013376 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 483219013377 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 483219013378 active site 483219013379 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 483219013380 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 483219013381 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 483219013382 catalytic site [active] 483219013383 subunit interface [polypeptide binding]; other site 483219013384 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 483219013385 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 483219013386 domain interfaces; other site 483219013387 active site 483219013388 Bifunctional nuclease; Region: DNase-RNase; pfam02577 483219013389 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 483219013390 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 483219013391 acyl-activating enzyme (AAE) consensus motif; other site 483219013392 putative AMP binding site [chemical binding]; other site 483219013393 putative active site [active] 483219013394 putative CoA binding site [chemical binding]; other site 483219013395 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 483219013396 Citrate synthase; Region: Citrate_synt; pfam00285 483219013397 oxalacetate binding site [chemical binding]; other site 483219013398 citrylCoA binding site [chemical binding]; other site 483219013399 coenzyme A binding site [chemical binding]; other site 483219013400 catalytic triad [active] 483219013401 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 483219013402 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 483219013403 putative active site [active] 483219013404 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 483219013405 active site 483219013406 NAD binding site [chemical binding]; other site 483219013407 metal binding site [ion binding]; metal-binding site 483219013408 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 483219013409 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 483219013410 Tetramer interface [polypeptide binding]; other site 483219013411 active site 483219013412 FMN-binding site [chemical binding]; other site 483219013413 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 483219013414 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 483219013415 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 483219013416 active site 483219013417 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 483219013418 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219013419 S-adenosylmethionine binding site [chemical binding]; other site 483219013420 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 483219013421 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 483219013422 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 483219013423 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 483219013424 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 483219013425 dimer interface [polypeptide binding]; other site 483219013426 tetramer interface [polypeptide binding]; other site 483219013427 PYR/PP interface [polypeptide binding]; other site 483219013428 TPP binding site [chemical binding]; other site 483219013429 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 483219013430 TPP-binding site; other site 483219013431 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 483219013432 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 483219013433 UbiA prenyltransferase family; Region: UbiA; pfam01040 483219013434 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 483219013435 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 483219013436 metal binding site [ion binding]; metal-binding site 483219013437 substrate binding pocket [chemical binding]; other site 483219013438 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 483219013439 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 483219013440 acyl-activating enzyme (AAE) consensus motif; other site 483219013441 putative AMP binding site [chemical binding]; other site 483219013442 putative active site [active] 483219013443 putative CoA binding site [chemical binding]; other site 483219013444 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 483219013445 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 483219013446 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 483219013447 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 483219013448 isocitrate dehydrogenase; Validated; Region: PRK07362 483219013449 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 483219013450 malate dehydrogenase; Reviewed; Region: PRK06223 483219013451 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 483219013452 NAD(P) binding site [chemical binding]; other site 483219013453 dimer interface [polypeptide binding]; other site 483219013454 tetramer (dimer of dimers) interface [polypeptide binding]; other site 483219013455 substrate binding site [chemical binding]; other site 483219013456 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 483219013457 L-aspartate oxidase; Provisional; Region: PRK06175 483219013458 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 483219013459 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 483219013460 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 483219013461 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 483219013462 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 483219013463 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 483219013464 CoA-ligase; Region: Ligase_CoA; pfam00549 483219013465 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 483219013466 CoA binding domain; Region: CoA_binding; smart00881 483219013467 CoA-ligase; Region: Ligase_CoA; pfam00549 483219013468 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 483219013469 active site 483219013470 multimer interface [polypeptide binding]; other site 483219013471 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 483219013472 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 483219013473 FeS/SAM binding site; other site 483219013474 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 483219013475 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 483219013476 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 483219013477 G-X-X-G motif; other site 483219013478 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 483219013479 RimM N-terminal domain; Region: RimM; pfam01782 483219013480 PRC-barrel domain; Region: PRC; pfam05239 483219013481 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 483219013482 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 483219013483 AAA domain; Region: AAA_27; pfam13514 483219013484 hypothetical protein; Reviewed; Region: PRK12497 483219013485 Predicted methyltransferases [General function prediction only]; Region: COG0313 483219013486 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 483219013487 putative SAM binding site [chemical binding]; other site 483219013488 putative homodimer interface [polypeptide binding]; other site 483219013489 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 483219013490 Peptidase family M23; Region: Peptidase_M23; pfam01551 483219013491 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 483219013492 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219013493 active site 483219013494 phosphorylation site [posttranslational modification] 483219013495 intermolecular recognition site; other site 483219013496 dimerization interface [polypeptide binding]; other site 483219013497 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219013498 Walker A motif; other site 483219013499 ATP binding site [chemical binding]; other site 483219013500 Walker B motif; other site 483219013501 arginine finger; other site 483219013502 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 483219013503 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 483219013504 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 483219013505 diiron binding motif [ion binding]; other site 483219013506 integral membrane protein MviN; Region: mviN; TIGR01695 483219013507 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 483219013508 30S ribosomal protein S1; Provisional; Region: rpsA; PRK13806 483219013509 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 483219013510 RNA binding site [nucleotide binding]; other site 483219013511 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 483219013512 RNA binding site [nucleotide binding]; other site 483219013513 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 483219013514 RNA binding site [nucleotide binding]; other site 483219013515 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 483219013516 RNA binding site [nucleotide binding]; other site 483219013517 domain interface; other site 483219013518 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 483219013519 RNA binding site [nucleotide binding]; other site 483219013520 phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259 483219013521 NmrA-like family; Region: NmrA; pfam05368 483219013522 NAD(P) binding site [chemical binding]; other site 483219013523 active site lysine 483219013524 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 483219013525 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 483219013526 PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818 483219013527 PA/protease or protease-like domain interface [polypeptide binding]; other site 483219013528 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 483219013529 Zn binding site [ion binding]; other site 483219013530 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 483219013531 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 483219013532 amidase; Provisional; Region: PRK08137 483219013533 Amidase; Region: Amidase; cl11426 483219013534 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 483219013535 Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; cl17879 483219013536 Methyltransferase domain; Region: Methyltransf_31; pfam13847 483219013537 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219013538 S-adenosylmethionine binding site [chemical binding]; other site 483219013539 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 483219013540 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 483219013541 active site 483219013542 DNA binding site [nucleotide binding] 483219013543 Int/Topo IB signature motif; other site 483219013544 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 483219013545 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 483219013546 ATPase involved in DNA repair; Region: DUF3686; pfam12458 483219013547 AAA domain; Region: AAA_22; pfam13401 483219013548 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219013549 Walker A motif; other site 483219013550 ATP binding site [chemical binding]; other site 483219013551 Walker B motif; other site 483219013552 arginine finger; other site 483219013553 Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305 483219013554 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 483219013555 von Willebrand factor; Region: vWF_A; pfam12450 483219013556 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 483219013557 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 483219013558 metal ion-dependent adhesion site (MIDAS); other site 483219013559 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 483219013560 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 483219013561 dimer interface [polypeptide binding]; other site 483219013562 substrate binding site [chemical binding]; other site 483219013563 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 483219013564 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 483219013565 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 483219013566 putative active site [active] 483219013567 putative metal binding site [ion binding]; other site 483219013568 short chain dehydrogenase; Provisional; Region: PRK08303 483219013569 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 483219013570 NAD(P) binding site [chemical binding]; other site 483219013571 active site 483219013572 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 483219013573 Peptidase family M2 Angiotensin converting enzyme (ACE); Region: M2_ACE; cd06461 483219013574 active site 483219013575 Zn binding site [ion binding]; other site 483219013576 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 483219013577 DNA-binding site [nucleotide binding]; DNA binding site 483219013578 RNA-binding motif; other site 483219013579 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 483219013580 Zn binding site [ion binding]; other site 483219013581 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 483219013582 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 483219013583 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 483219013584 PilZ domain; Region: PilZ; pfam07238 483219013585 PEGA domain; Region: PEGA; pfam08308 483219013586 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 483219013587 Domain of unknown function DUF20; Region: UPF0118; pfam01594 483219013588 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 483219013589 Fe-S cluster binding site [ion binding]; other site 483219013590 DNA binding site [nucleotide binding] 483219013591 active site 483219013592 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 483219013593 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 483219013594 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 483219013595 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 483219013596 active site 483219013597 dimer interface [polypeptide binding]; other site 483219013598 motif 1; other site 483219013599 motif 2; other site 483219013600 motif 3; other site 483219013601 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 483219013602 anticodon binding site; other site 483219013603 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 483219013604 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 483219013605 23S rRNA binding site [nucleotide binding]; other site 483219013606 L21 binding site [polypeptide binding]; other site 483219013607 L13 binding site [polypeptide binding]; other site 483219013608 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 483219013609 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 483219013610 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 483219013611 dimer interface [polypeptide binding]; other site 483219013612 motif 1; other site 483219013613 active site 483219013614 motif 2; other site 483219013615 motif 3; other site 483219013616 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 483219013617 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 483219013618 putative tRNA-binding site [nucleotide binding]; other site 483219013619 B3/4 domain; Region: B3_4; pfam03483 483219013620 tRNA synthetase B5 domain; Region: B5; smart00874 483219013621 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 483219013622 dimer interface [polypeptide binding]; other site 483219013623 motif 1; other site 483219013624 motif 3; other site 483219013625 motif 2; other site 483219013626 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 483219013627 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 483219013628 IHF dimer interface [polypeptide binding]; other site 483219013629 IHF - DNA interface [nucleotide binding]; other site 483219013630 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 483219013631 Mrr N-terminal domain; Region: Mrr_N; pfam14338 483219013632 Restriction endonuclease; Region: Mrr_cat; pfam04471 483219013633 putative transposase OrfB; Reviewed; Region: PHA02517 483219013634 Homeodomain-like domain; Region: HTH_32; pfam13565 483219013635 Integrase core domain; Region: rve; pfam00665 483219013636 Integrase core domain; Region: rve_3; pfam13683 483219013637 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 483219013638 Integrase core domain; Region: rve; pfam00665 483219013639 Integrase core domain; Region: rve_3; cl15866 483219013640 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219013641 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 483219013642 Walker A motif; other site 483219013643 ATP binding site [chemical binding]; other site 483219013644 Walker B motif; other site 483219013645 Transposase; Region: HTH_Tnp_1; cl17663 483219013646 putative transposase OrfB; Reviewed; Region: PHA02517 483219013647 Homeodomain-like domain; Region: HTH_32; pfam13565 483219013648 Integrase core domain; Region: rve; pfam00665 483219013649 Integrase core domain; Region: rve_3; pfam13683 483219013650 Integrase core domain; Region: rve_3; pfam13683 483219013651 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 483219013652 Integrase core domain; Region: rve; pfam00665 483219013653 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219013654 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 483219013655 Walker A motif; other site 483219013656 ATP binding site [chemical binding]; other site 483219013657 Walker B motif; other site 483219013658 Winged helix-turn helix; Region: HTH_29; pfam13551 483219013659 Homeodomain-like domain; Region: HTH_32; pfam13565 483219013660 Integrase core domain; Region: rve; pfam00665 483219013661 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219013662 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 483219013663 Walker A motif; other site 483219013664 ATP binding site [chemical binding]; other site 483219013665 Walker B motif; other site 483219013666 Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117 483219013667 homodimer interface [polypeptide binding]; other site 483219013668 putative active site [active] 483219013669 catalytic site [active] 483219013670 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 483219013671 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 483219013672 ATP binding site [chemical binding]; other site 483219013673 putative Mg++ binding site [ion binding]; other site 483219013674 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 483219013675 ATP-binding site [chemical binding]; other site 483219013676 Homeodomain-like domain; Region: HTH_23; cl17451 483219013677 Transposase domain (DUF772); Region: DUF772; pfam05598 483219013678 Helix-turn-helix domain; Region: HTH_28; pfam13518 483219013679 Winged helix-turn helix; Region: HTH_29; pfam13551 483219013680 Winged helix-turn helix; Region: HTH_33; pfam13592 483219013681 DDE superfamily endonuclease; Region: DDE_3; pfam13358 483219013682 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 483219013683 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 483219013684 active site residue [active] 483219013685 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 483219013686 active site residue [active] 483219013687 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 483219013688 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 483219013689 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 483219013690 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 483219013691 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 483219013692 Soluble P-type ATPase [General function prediction only]; Region: COG4087 483219013693 potential protein location (hypothetical protein) that overlaps protein (cation-translocating P-type ATPase with extended N-terminal transmembrane region) 483219013694 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 483219013695 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 483219013696 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 483219013697 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 483219013698 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 483219013699 motif II; other site 483219013700 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 483219013701 Uncharacterized conserved protein [Function unknown]; Region: COG0398 483219013702 PAS domain S-box; Region: sensory_box; TIGR00229 483219013703 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219013704 putative active site [active] 483219013705 heme pocket [chemical binding]; other site 483219013706 PAS domain S-box; Region: sensory_box; TIGR00229 483219013707 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219013708 putative active site [active] 483219013709 heme pocket [chemical binding]; other site 483219013710 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 483219013711 GAF domain; Region: GAF; cl17456 483219013712 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219013713 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219013714 dimer interface [polypeptide binding]; other site 483219013715 phosphorylation site [posttranslational modification] 483219013716 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219013717 ATP binding site [chemical binding]; other site 483219013718 Mg2+ binding site [ion binding]; other site 483219013719 G-X-G motif; other site 483219013720 Condensation domain; Region: Condensation; pfam00668 483219013721 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219013722 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219013723 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 483219013724 acyl-activating enzyme (AAE) consensus motif; other site 483219013725 AMP binding site [chemical binding]; other site 483219013726 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219013727 Condensation domain; Region: Condensation; pfam00668 483219013728 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 483219013729 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 483219013730 acyl-activating enzyme (AAE) consensus motif; other site 483219013731 AMP binding site [chemical binding]; other site 483219013732 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 483219013733 AMP binding site [chemical binding]; other site 483219013734 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219013735 Condensation domain; Region: Condensation; pfam00668 483219013736 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219013737 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219013738 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 483219013739 acyl-activating enzyme (AAE) consensus motif; other site 483219013740 AMP binding site [chemical binding]; other site 483219013741 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219013742 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 483219013743 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 483219013744 acyl-activating enzyme (AAE) consensus motif; other site 483219013745 AMP binding site [chemical binding]; other site 483219013746 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219013747 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 483219013748 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 483219013749 Condensation domain; Region: Condensation; pfam00668 483219013750 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219013751 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219013752 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 483219013753 acyl-activating enzyme (AAE) consensus motif; other site 483219013754 active site 483219013755 AMP binding site [chemical binding]; other site 483219013756 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 483219013757 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 483219013758 active site 483219013759 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 483219013760 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 483219013761 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 483219013762 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 483219013763 putative NADP binding site [chemical binding]; other site 483219013764 active site 483219013765 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219013766 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 483219013767 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 483219013768 active site 483219013769 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 483219013770 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 483219013771 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 483219013772 putative NADP binding site [chemical binding]; other site 483219013773 active site 483219013774 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219013775 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 483219013776 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 483219013777 active site 483219013778 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 483219013779 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 483219013780 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219013781 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 483219013782 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 483219013783 GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039 483219013784 glutathione s-transferase; Provisional; Region: PTZ00057 483219013785 GSH binding site (G-site) [chemical binding]; other site 483219013786 C-terminal domain interface [polypeptide binding]; other site 483219013787 dimer interface [polypeptide binding]; other site 483219013788 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 483219013789 N-terminal domain interface [polypeptide binding]; other site 483219013790 dimer interface [polypeptide binding]; other site 483219013791 substrate binding pocket (H-site) [chemical binding]; other site 483219013792 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 483219013793 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 483219013794 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 483219013795 Cupin-like domain; Region: Cupin_8; pfam13621 483219013796 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 483219013797 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 483219013798 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 483219013799 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 483219013800 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 483219013801 active site 483219013802 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 483219013803 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219013804 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 483219013805 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 483219013806 active site 483219013807 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 483219013808 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 483219013809 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 483219013810 putative NADP binding site [chemical binding]; other site 483219013811 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 483219013812 active site 483219013813 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219013814 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 483219013815 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 483219013816 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 483219013817 ABC-type siderophore export system, fused ATPase and permease components [Secondary metabolites biosynthesis, transport, and catabolism / Inorganic ion transport and metabolism]; Region: PvdE; COG4615 483219013818 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219013819 Walker A/P-loop; other site 483219013820 ATP binding site [chemical binding]; other site 483219013821 Q-loop/lid; other site 483219013822 ABC transporter signature motif; other site 483219013823 Walker B; other site 483219013824 D-loop; other site 483219013825 H-loop/switch region; other site 483219013826 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 483219013827 acyl-CoA synthetase; Validated; Region: PRK05850 483219013828 acyl-activating enzyme (AAE) consensus motif; other site 483219013829 active site 483219013830 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219013831 Condensation domain; Region: Condensation; pfam00668 483219013832 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219013833 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219013834 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 483219013835 acyl-activating enzyme (AAE) consensus motif; other site 483219013836 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 483219013837 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 483219013838 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 483219013839 AMP binding site [chemical binding]; other site 483219013840 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219013841 Condensation domain; Region: Condensation; pfam00668 483219013842 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219013843 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219013844 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 483219013845 acyl-activating enzyme (AAE) consensus motif; other site 483219013846 AMP binding site [chemical binding]; other site 483219013847 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219013848 Condensation domain; Region: Condensation; pfam00668 483219013849 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219013850 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 483219013851 Condensation domain; Region: Condensation; pfam00668 483219013852 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219013853 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 483219013854 acyl-activating enzyme (AAE) consensus motif; other site 483219013855 AMP binding site [chemical binding]; other site 483219013856 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219013857 Condensation domain; Region: Condensation; pfam00668 483219013858 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219013859 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219013860 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 483219013861 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 483219013862 acyl-activating enzyme (AAE) consensus motif; other site 483219013863 AMP binding site [chemical binding]; other site 483219013864 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219013865 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 483219013866 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 483219013867 active site 483219013868 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 483219013869 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 483219013870 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219013871 Condensation domain; Region: Condensation; pfam00668 483219013872 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219013873 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219013874 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 483219013875 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 483219013876 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 483219013877 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 483219013878 Condensation domain; Region: Condensation; pfam00668 483219013879 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219013880 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219013881 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 483219013882 acyl-activating enzyme (AAE) consensus motif; other site 483219013883 AMP binding site [chemical binding]; other site 483219013884 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219013885 Condensation domain; Region: Condensation; pfam00668 483219013886 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219013887 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 483219013888 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 483219013889 Condensation domain; Region: Condensation; pfam00668 483219013890 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219013891 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219013892 Condensation domain; Region: Condensation; pfam00668 483219013893 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219013894 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219013895 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 483219013896 acyl-activating enzyme (AAE) consensus motif; other site 483219013897 AMP binding site [chemical binding]; other site 483219013898 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219013899 Condensation domain; Region: Condensation; pfam00668 483219013900 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219013901 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219013902 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 483219013903 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 483219013904 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 483219013905 acyl-activating enzyme (AAE) consensus motif; other site 483219013906 AMP binding site [chemical binding]; other site 483219013907 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219013908 Condensation domain; Region: Condensation; pfam00668 483219013909 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219013910 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219013911 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 483219013912 acyl-activating enzyme (AAE) consensus motif; other site 483219013913 AMP binding site [chemical binding]; other site 483219013914 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219013915 Condensation domain; Region: Condensation; pfam00668 483219013916 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219013917 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219013918 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 483219013919 acyl-activating enzyme (AAE) consensus motif; other site 483219013920 AMP binding site [chemical binding]; other site 483219013921 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219013922 Condensation domain; Region: Condensation; pfam00668 483219013923 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219013924 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219013925 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 483219013926 acyl-activating enzyme (AAE) consensus motif; other site 483219013927 AMP binding site [chemical binding]; other site 483219013928 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219013929 Condensation domain; Region: Condensation; pfam00668 483219013930 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 483219013931 active site 483219013932 AMP binding site [chemical binding]; other site 483219013933 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219013934 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 483219013935 acyl-activating enzyme (AAE) consensus motif; other site 483219013936 active site 483219013937 AMP binding site [chemical binding]; other site 483219013938 CoA binding site [chemical binding]; other site 483219013939 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 483219013940 CoA binding site [chemical binding]; other site 483219013941 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219013942 Condensation domain; Region: Condensation; pfam00668 483219013943 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219013944 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219013945 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 483219013946 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 483219013947 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 483219013948 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219013949 Condensation domain; Region: Condensation; pfam00668 483219013950 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219013951 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219013952 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 483219013953 acyl-activating enzyme (AAE) consensus motif; other site 483219013954 AMP binding site [chemical binding]; other site 483219013955 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219013956 Condensation domain; Region: Condensation; pfam00668 483219013957 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219013958 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219013959 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 483219013960 acyl-activating enzyme (AAE) consensus motif; other site 483219013961 AMP binding site [chemical binding]; other site 483219013962 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219013963 Condensation domain; Region: Condensation; pfam00668 483219013964 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219013965 acyl-CoA synthetase; Validated; Region: PRK06178 483219013966 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 483219013967 acyl-activating enzyme (AAE) consensus motif; other site 483219013968 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 483219013969 acyl-activating enzyme (AAE) consensus motif; other site 483219013970 AMP binding site [chemical binding]; other site 483219013971 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219013972 Condensation domain; Region: Condensation; pfam00668 483219013973 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219013974 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219013975 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 483219013976 acyl-activating enzyme (AAE) consensus motif; other site 483219013977 AMP binding site [chemical binding]; other site 483219013978 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219013979 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 483219013980 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 483219013981 AMP binding site [chemical binding]; other site 483219013982 active site 483219013983 acyl-activating enzyme (AAE) consensus motif; other site 483219013984 CoA binding site [chemical binding]; other site 483219013985 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219013986 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 483219013987 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219013988 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 483219013989 acyl-activating enzyme (AAE) consensus motif; other site 483219013990 AMP binding site [chemical binding]; other site 483219013991 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219013992 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 483219013993 active site 483219013994 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 483219013995 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 483219013996 FAD binding pocket [chemical binding]; other site 483219013997 FAD binding motif [chemical binding]; other site 483219013998 phosphate binding motif [ion binding]; other site 483219013999 NAD binding pocket [chemical binding]; other site 483219014000 Double zinc ribbon; Region: DZR; pfam12773 483219014001 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 483219014002 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 483219014003 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 483219014004 catalytic residue [active] 483219014005 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 483219014006 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483219014007 putative substrate translocation pore; other site 483219014008 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 483219014009 Condensation domain; Region: Condensation; pfam00668 483219014010 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 483219014011 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 483219014012 acyl-activating enzyme (AAE) consensus motif; other site 483219014013 AMP binding site [chemical binding]; other site 483219014014 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219014015 thioester reductase domain; Region: Thioester-redct; TIGR01746 483219014016 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 483219014017 putative NAD(P) binding site [chemical binding]; other site 483219014018 active site 483219014019 putative substrate binding site [chemical binding]; other site 483219014020 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 483219014021 Isochorismatase family; Region: Isochorismatase; pfam00857 483219014022 catalytic triad [active] 483219014023 conserved cis-peptide bond; other site 483219014024 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 483219014025 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 483219014026 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 483219014027 acyl-activating enzyme (AAE) consensus motif; other site 483219014028 active site 483219014029 AMP binding site [chemical binding]; other site 483219014030 substrate binding site [chemical binding]; other site 483219014031 isochorismate synthase DhbC; Validated; Region: PRK06923 483219014032 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 483219014033 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316 483219014034 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 483219014035 NAD(P) binding site [chemical binding]; other site 483219014036 active site 483219014037 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 483219014038 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 483219014039 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 483219014040 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 483219014041 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 483219014042 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 483219014043 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 483219014044 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 483219014045 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219014046 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219014047 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 483219014048 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219014049 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219014050 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219014051 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219014052 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219014053 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219014054 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219014055 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219014056 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219014057 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219014058 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219014059 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219014060 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219014061 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219014062 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219014063 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 483219014064 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219014065 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219014066 active site 483219014067 ATP binding site [chemical binding]; other site 483219014068 substrate binding site [chemical binding]; other site 483219014069 activation loop (A-loop); other site 483219014070 Tetratricopeptide repeat; Region: TPR_12; pfam13424 483219014071 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219014072 binding surface 483219014073 TPR motif; other site 483219014074 Tetratricopeptide repeat; Region: TPR_12; pfam13424 483219014075 RNA polymerase sigma-70 factor, Myxococcales family 1; Region: Sig-70_gmx1; TIGR03001 483219014076 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 483219014077 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 483219014078 putative C-terminal domain interface [polypeptide binding]; other site 483219014079 putative GSH binding site (G-site) [chemical binding]; other site 483219014080 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 483219014081 putative dimer interface [polypeptide binding]; other site 483219014082 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 483219014083 N-terminal domain interface [polypeptide binding]; other site 483219014084 dimer interface [polypeptide binding]; other site 483219014085 substrate binding pocket (H-site) [chemical binding]; other site 483219014086 hypothetical protein; Provisional; Region: PRK07505 483219014087 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 483219014088 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 483219014089 catalytic residue [active] 483219014090 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 483219014091 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 483219014092 putative active site [active] 483219014093 putative catalytic site [active] 483219014094 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 483219014095 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 483219014096 NAD(P) binding site [chemical binding]; other site 483219014097 Uncharacterized conserved protein [Function unknown]; Region: COG1262 483219014098 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 483219014099 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 483219014100 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 483219014101 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 483219014102 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219014103 dimerization interface [polypeptide binding]; other site 483219014104 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 483219014105 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 483219014106 dimer interface [polypeptide binding]; other site 483219014107 putative CheW interface [polypeptide binding]; other site 483219014108 Isochorismatase family; Region: Isochorismatase; pfam00857 483219014109 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 483219014110 catalytic triad [active] 483219014111 conserved cis-peptide bond; other site 483219014112 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 483219014113 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 483219014114 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 483219014115 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 483219014116 HlyD family secretion protein; Region: HlyD_3; pfam13437 483219014117 Outer membrane efflux protein; Region: OEP; pfam02321 483219014118 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 483219014119 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 483219014120 HlyD family secretion protein; Region: HlyD_3; pfam13437 483219014121 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 483219014122 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 483219014123 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 483219014124 catalytic residues [active] 483219014125 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 483219014126 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 483219014127 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 483219014128 Fungalysin metallopeptidase (M36); Region: Peptidase_M36; pfam02128 483219014129 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 483219014130 Zn binding site [ion binding]; other site 483219014131 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 483219014132 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 483219014133 substrate binding pocket [chemical binding]; other site 483219014134 chain length determination region; other site 483219014135 substrate-Mg2+ binding site; other site 483219014136 catalytic residues [active] 483219014137 aspartate-rich region 1; other site 483219014138 active site lid residues [active] 483219014139 aspartate-rich region 2; other site 483219014140 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 483219014141 dimerization interface [polypeptide binding]; other site 483219014142 putative Zn2+ binding site [ion binding]; other site 483219014143 putative DNA binding site [nucleotide binding]; other site 483219014144 dimerization interface [polypeptide binding]; other site 483219014145 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 483219014146 putative catalytic residue [active] 483219014147 glycogen branching enzyme; Provisional; Region: PRK05402 483219014148 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 483219014149 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 483219014150 active site 483219014151 catalytic site [active] 483219014152 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 483219014153 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 483219014154 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 483219014155 trehalose synthase; Region: treS_nterm; TIGR02456 483219014156 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 483219014157 active site 483219014158 catalytic site [active] 483219014159 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 483219014160 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 483219014161 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 483219014162 active site 483219014163 homodimer interface [polypeptide binding]; other site 483219014164 catalytic site [active] 483219014165 acceptor binding site [chemical binding]; other site 483219014166 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 483219014167 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 483219014168 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 483219014169 DNA binding residues [nucleotide binding] 483219014170 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 483219014171 putative active site [active] 483219014172 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 483219014173 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219014174 active site 483219014175 phosphorylation site [posttranslational modification] 483219014176 intermolecular recognition site; other site 483219014177 dimerization interface [polypeptide binding]; other site 483219014178 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 483219014179 DNA binding site [nucleotide binding] 483219014180 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219014181 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 483219014182 dimerization interface [polypeptide binding]; other site 483219014183 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219014184 dimer interface [polypeptide binding]; other site 483219014185 phosphorylation site [posttranslational modification] 483219014186 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219014187 ATP binding site [chemical binding]; other site 483219014188 Mg2+ binding site [ion binding]; other site 483219014189 G-X-G motif; other site 483219014190 TIGR02646 family protein; Region: TIGR02646 483219014191 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219014192 Walker A/P-loop; other site 483219014193 ATP binding site [chemical binding]; other site 483219014194 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 483219014195 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 483219014196 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 483219014197 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 483219014198 Domain of unknown function (DUF4382); Region: DUF4382; pfam14321 483219014199 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 483219014200 phosphopeptide binding site; other site 483219014201 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219014202 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 483219014203 Walker A motif; other site 483219014204 ATP binding site [chemical binding]; other site 483219014205 Walker B motif; other site 483219014206 arginine finger; other site 483219014207 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 483219014208 Protein kinase domain; Region: Pkinase; pfam00069 483219014209 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219014210 active site 483219014211 ATP binding site [chemical binding]; other site 483219014212 substrate binding site [chemical binding]; other site 483219014213 activation loop (A-loop); other site 483219014214 Vitamin K epoxide reductase family in bacteria; Region: VKOR_3; cd12920 483219014215 putative active site [active] 483219014216 redox center [active] 483219014217 Thioredoxin; Region: Thioredoxin_4; cl17273 483219014218 TPR repeat; Region: TPR_11; pfam13414 483219014219 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219014220 TPR motif; other site 483219014221 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 483219014222 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 483219014223 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 483219014224 active site 483219014225 catalytic site [active] 483219014226 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 483219014227 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 483219014228 active site 483219014229 PHP-associated; Region: PHP_C; pfam13263 483219014230 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 483219014231 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 483219014232 metal binding site 2 [ion binding]; metal-binding site 483219014233 putative DNA binding helix; other site 483219014234 metal binding site 1 [ion binding]; metal-binding site 483219014235 dimer interface [polypeptide binding]; other site 483219014236 structural Zn2+ binding site [ion binding]; other site 483219014237 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 483219014238 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 483219014239 catalytic residues [active] 483219014240 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 483219014241 Septum formation initiator; Region: DivIC; pfam04977 483219014242 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 483219014243 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 483219014244 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 483219014245 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 483219014246 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 483219014247 metal binding site [ion binding]; metal-binding site 483219014248 active site 483219014249 I-site; other site 483219014250 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 483219014251 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 483219014252 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219014253 S-adenosylmethionine binding site [chemical binding]; other site 483219014254 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 483219014255 putative active site [active] 483219014256 5' nucleotidase family; Region: 5_nucleotid; pfam05761 483219014257 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219014258 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219014259 active site 483219014260 ATP binding site [chemical binding]; other site 483219014261 substrate binding site [chemical binding]; other site 483219014262 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 483219014263 substrate binding site [chemical binding]; other site 483219014264 activation loop (A-loop); other site 483219014265 activation loop (A-loop); other site 483219014266 PEGA domain; Region: PEGA; pfam08308 483219014267 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 483219014268 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219014269 active site 483219014270 phosphorylation site [posttranslational modification] 483219014271 intermolecular recognition site; other site 483219014272 dimerization interface [polypeptide binding]; other site 483219014273 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 483219014274 DNA binding residues [nucleotide binding] 483219014275 dimerization interface [polypeptide binding]; other site 483219014276 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 483219014277 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 483219014278 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 483219014279 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 483219014280 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 483219014281 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 483219014282 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 483219014283 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 483219014284 active site 483219014285 DUSAM domain; Region: TIGR02267 483219014286 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 483219014287 Permease; Region: Permease; pfam02405 483219014288 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 483219014289 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 483219014290 Walker A/P-loop; other site 483219014291 ATP binding site [chemical binding]; other site 483219014292 Q-loop/lid; other site 483219014293 ABC transporter signature motif; other site 483219014294 Walker B; other site 483219014295 D-loop; other site 483219014296 H-loop/switch region; other site 483219014297 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 483219014298 mce related protein; Region: MCE; pfam02470 483219014299 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 483219014300 substrate binding site [chemical binding]; other site 483219014301 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 483219014302 ATP binding site [chemical binding]; other site 483219014303 Myxococcus xanthus paralogous domain TIGR02266; Region: gmx_TIGR02266 483219014304 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 483219014305 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 483219014306 active site 483219014307 metal binding site [ion binding]; metal-binding site 483219014308 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 483219014309 histidyl-tRNA synthetase; Region: hisS; TIGR00442 483219014310 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 483219014311 dimer interface [polypeptide binding]; other site 483219014312 motif 1; other site 483219014313 active site 483219014314 motif 2; other site 483219014315 motif 3; other site 483219014316 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 483219014317 anticodon binding site; other site 483219014318 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 483219014319 Catalytic site [active] 483219014320 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 483219014321 PQQ-like domain; Region: PQQ_2; pfam13360 483219014322 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 483219014323 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 483219014324 Trp docking motif [polypeptide binding]; other site 483219014325 active site 483219014326 F420-dependent oxidoreductase, CPS_4043 family; Region: F420_CPS_4043; TIGR03842 483219014327 HprK-related kinase A; Region: HprK_rel_A; TIGR04352 483219014328 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 483219014329 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 483219014330 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 483219014331 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 483219014332 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219014333 Response regulator receiver domain; Region: Response_reg; pfam00072 483219014334 active site 483219014335 phosphorylation site [posttranslational modification] 483219014336 intermolecular recognition site; other site 483219014337 dimerization interface [polypeptide binding]; other site 483219014338 Response regulator receiver domain; Region: Response_reg; pfam00072 483219014339 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219014340 active site 483219014341 phosphorylation site [posttranslational modification] 483219014342 intermolecular recognition site; other site 483219014343 dimerization interface [polypeptide binding]; other site 483219014344 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 483219014345 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 483219014346 metal binding site [ion binding]; metal-binding site 483219014347 active site 483219014348 I-site; other site 483219014349 Tetratricopeptide repeat; Region: TPR_16; pfam13432 483219014350 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 483219014351 TPR motif; other site 483219014352 binding surface 483219014353 Response regulator receiver domain; Region: Response_reg; pfam00072 483219014354 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219014355 active site 483219014356 phosphorylation site [posttranslational modification] 483219014357 intermolecular recognition site; other site 483219014358 dimerization interface [polypeptide binding]; other site 483219014359 potential frameshift: common BLAST hit: gi|310821489|ref|YP_003953847.1| methyltransferase 483219014360 potential protein location (hypothetical protein LILAB_26885 [Myxococcus fulvus HW-1]) that overlaps RNA (tRNA-A) 483219014361 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 483219014362 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 483219014363 putative active site; other site 483219014364 catalytic residue [active] 483219014365 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 483219014366 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 483219014367 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 483219014368 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 483219014369 NAD(P) binding site [chemical binding]; other site 483219014370 active site 483219014371 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 483219014372 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 483219014373 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 483219014374 catalytic residue [active] 483219014375 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 483219014376 active site 483219014377 PAP2 superfamily; Region: PAP2; pfam01569 483219014378 aminotransferase; Validated; Region: PRK07777 483219014379 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 483219014380 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483219014381 homodimer interface [polypeptide binding]; other site 483219014382 catalytic residue [active] 483219014383 Methyltransferase domain; Region: Methyltransf_23; pfam13489 483219014384 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219014385 S-adenosylmethionine binding site [chemical binding]; other site 483219014386 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 483219014387 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 483219014388 active site 483219014389 catalytic residues [active] 483219014390 metal binding site [ion binding]; metal-binding site 483219014391 Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978 483219014392 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 483219014393 Double zinc ribbon; Region: DZR; pfam12773 483219014394 tellurium resistance terB-like protein; Region: terB_like; cd07177 483219014395 metal binding site [ion binding]; metal-binding site 483219014396 tellurium resistance terB-like protein; Region: terB_like; cd07177 483219014397 metal binding site [ion binding]; metal-binding site 483219014398 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 483219014399 enoyl-CoA hydratase; Provisional; Region: PRK07657 483219014400 substrate binding site [chemical binding]; other site 483219014401 oxyanion hole (OAH) forming residues; other site 483219014402 trimer interface [polypeptide binding]; other site 483219014403 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 483219014404 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 483219014405 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 483219014406 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 483219014407 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 483219014408 active site 483219014409 ribonuclease III; Reviewed; Region: rnc; PRK00102 483219014410 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 483219014411 dimerization interface [polypeptide binding]; other site 483219014412 active site 483219014413 metal binding site [ion binding]; metal-binding site 483219014414 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 483219014415 dsRNA binding site [nucleotide binding]; other site 483219014416 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 483219014417 active site 483219014418 GTPase Era; Reviewed; Region: era; PRK00089 483219014419 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 483219014420 G1 box; other site 483219014421 GTP/Mg2+ binding site [chemical binding]; other site 483219014422 Switch I region; other site 483219014423 G2 box; other site 483219014424 Switch II region; other site 483219014425 G3 box; other site 483219014426 G4 box; other site 483219014427 G5 box; other site 483219014428 KH domain; Region: KH_2; pfam07650 483219014429 GTP-binding protein Der; Reviewed; Region: PRK00093 483219014430 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 483219014431 G1 box; other site 483219014432 GTP/Mg2+ binding site [chemical binding]; other site 483219014433 Switch I region; other site 483219014434 G2 box; other site 483219014435 Switch II region; other site 483219014436 G3 box; other site 483219014437 G4 box; other site 483219014438 G5 box; other site 483219014439 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 483219014440 G1 box; other site 483219014441 GTP/Mg2+ binding site [chemical binding]; other site 483219014442 Switch I region; other site 483219014443 G2 box; other site 483219014444 G3 box; other site 483219014445 Switch II region; other site 483219014446 G4 box; other site 483219014447 G5 box; other site 483219014448 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219014449 TPR motif; other site 483219014450 binding surface 483219014451 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 483219014452 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 483219014453 Trp docking motif [polypeptide binding]; other site 483219014454 PQQ-like domain; Region: PQQ_2; pfam13360 483219014455 active site 483219014456 PQQ-like domain; Region: PQQ_2; pfam13360 483219014457 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 483219014458 active site 483219014459 8-oxo-dGMP binding site [chemical binding]; other site 483219014460 nudix motif; other site 483219014461 metal binding site [ion binding]; metal-binding site 483219014462 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 483219014463 RNase_H superfamily; Region: RNase_H_2; pfam13482 483219014464 Protein of unknown function (DUF3014); Region: DUF3014; pfam11219 483219014465 histidinol-phosphatase; Validated; Region: PRK06740 483219014466 potential frameshift: common BLAST hit: gi|108763121|ref|YP_631955.1| putative permease 483219014467 Peptidase S46; Region: Peptidase_S46; pfam10459 483219014468 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 483219014469 GMP synthase; Reviewed; Region: guaA; PRK00074 483219014470 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 483219014471 AMP/PPi binding site [chemical binding]; other site 483219014472 candidate oxyanion hole; other site 483219014473 catalytic triad [active] 483219014474 potential glutamine specificity residues [chemical binding]; other site 483219014475 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 483219014476 ATP Binding subdomain [chemical binding]; other site 483219014477 Ligand Binding sites [chemical binding]; other site 483219014478 Dimerization subdomain; other site 483219014479 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 483219014480 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 483219014481 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 483219014482 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 483219014483 active site 483219014484 PilZ domain; Region: PilZ; cl01260 483219014485 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 483219014486 nucleotide binding site [chemical binding]; other site 483219014487 acyl-CoA synthetase; Validated; Region: PRK05850 483219014488 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 483219014489 acyl-activating enzyme (AAE) consensus motif; other site 483219014490 active site 483219014491 Condensation domain; Region: Condensation; pfam00668 483219014492 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219014493 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219014494 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 483219014495 acyl-activating enzyme (AAE) consensus motif; other site 483219014496 AMP binding site [chemical binding]; other site 483219014497 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 483219014498 Methyltransferase domain; Region: Methyltransf_31; pfam13847 483219014499 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219014500 S-adenosylmethionine binding site [chemical binding]; other site 483219014501 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 483219014502 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219014503 Condensation domain; Region: Condensation; pfam00668 483219014504 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219014505 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219014506 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 483219014507 acyl-activating enzyme (AAE) consensus motif; other site 483219014508 AMP binding site [chemical binding]; other site 483219014509 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219014510 Condensation domain; Region: Condensation; pfam00668 483219014511 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219014512 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219014513 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 483219014514 acyl-activating enzyme (AAE) consensus motif; other site 483219014515 AMP binding site [chemical binding]; other site 483219014516 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219014517 Condensation domain; Region: Condensation; pfam00668 483219014518 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219014519 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219014520 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 483219014521 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 483219014522 acyl-activating enzyme (AAE) consensus motif; other site 483219014523 AMP binding site [chemical binding]; other site 483219014524 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219014525 Condensation domain; Region: Condensation; pfam00668 483219014526 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219014527 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219014528 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 483219014529 acyl-activating enzyme (AAE) consensus motif; other site 483219014530 AMP binding site [chemical binding]; other site 483219014531 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219014532 Condensation domain; Region: Condensation; pfam00668 483219014533 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219014534 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219014535 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 483219014536 acyl-activating enzyme (AAE) consensus motif; other site 483219014537 AMP binding site [chemical binding]; other site 483219014538 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219014539 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 483219014540 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 483219014541 active site 483219014542 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 483219014543 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 483219014544 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219014545 Condensation domain; Region: Condensation; pfam00668 483219014546 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219014547 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219014548 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 483219014549 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 483219014550 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 483219014551 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 483219014552 Condensation domain; Region: Condensation; pfam00668 483219014553 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219014554 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219014555 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 483219014556 acyl-activating enzyme (AAE) consensus motif; other site 483219014557 AMP binding site [chemical binding]; other site 483219014558 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219014559 Condensation domain; Region: Condensation; pfam00668 483219014560 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219014561 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219014562 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 483219014563 acyl-activating enzyme (AAE) consensus motif; other site 483219014564 AMP binding site [chemical binding]; other site 483219014565 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219014566 Condensation domain; Region: Condensation; pfam00668 483219014567 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219014568 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219014569 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 483219014570 acyl-activating enzyme (AAE) consensus motif; other site 483219014571 AMP binding site [chemical binding]; other site 483219014572 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219014573 Condensation domain; Region: Condensation; pfam00668 483219014574 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219014575 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219014576 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 483219014577 acyl-activating enzyme (AAE) consensus motif; other site 483219014578 AMP binding site [chemical binding]; other site 483219014579 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219014580 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 483219014581 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219014582 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 483219014583 acyl-activating enzyme (AAE) consensus motif; other site 483219014584 AMP binding site [chemical binding]; other site 483219014585 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219014586 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 483219014587 Cornifin (SPRR) family; Region: Cornifin; pfam02389 483219014588 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 483219014589 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 483219014590 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 483219014591 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 483219014592 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 483219014593 ligand binding site [chemical binding]; other site 483219014594 flexible hinge region; other site 483219014595 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 483219014596 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 483219014597 trimer interface [polypeptide binding]; other site 483219014598 putative metal binding site [ion binding]; other site 483219014599 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 483219014600 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 483219014601 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 483219014602 FeS/SAM binding site; other site 483219014603 TRAM domain; Region: TRAM; pfam01938 483219014604 Protein of unknown function DUF262; Region: DUF262; pfam03235 483219014605 Uncharacterized conserved protein [Function unknown]; Region: COG1479 483219014606 Uncharacterized conserved protein [Function unknown]; Region: COG4938 483219014607 Protein of unknown function (DUF3696); Region: DUF3696; pfam12476 483219014608 Phage minor tail protein; Region: Phage_min_tail; cl01940 483219014609 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 483219014610 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 483219014611 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 483219014612 TRAM domain; Region: TRAM; cl01282 483219014613 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219014614 S-adenosylmethionine binding site [chemical binding]; other site 483219014615 Myxococcus xanthus paralogous domain TIGR02266; Region: gmx_TIGR02266 483219014616 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 483219014617 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 483219014618 putative acyltransferase; Provisional; Region: PRK05790 483219014619 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 483219014620 dimer interface [polypeptide binding]; other site 483219014621 active site 483219014622 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 483219014623 structural tetrad; other site 483219014624 FOG: WD40 repeat [General function prediction only]; Region: COG2319 483219014625 FOG: WD40 repeat [General function prediction only]; Region: COG2319 483219014626 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 483219014627 structural tetrad; other site 483219014628 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 483219014629 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 483219014630 RNA binding site [nucleotide binding]; other site 483219014631 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 483219014632 RNA binding site [nucleotide binding]; other site 483219014633 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 483219014634 RNA binding site [nucleotide binding]; other site 483219014635 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 483219014636 RNA binding site [nucleotide binding]; other site 483219014637 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 483219014638 RNA binding site [nucleotide binding]; other site 483219014639 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 483219014640 RNA binding site [nucleotide binding]; other site 483219014641 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 483219014642 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 483219014643 active site 483219014644 Gram-negative bacterial tonB protein; Region: TonB; cl10048 483219014645 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 483219014646 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 483219014647 FAD binding site [chemical binding]; other site 483219014648 homotetramer interface [polypeptide binding]; other site 483219014649 substrate binding pocket [chemical binding]; other site 483219014650 catalytic base [active] 483219014651 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 483219014652 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 483219014653 substrate binding site [chemical binding]; other site 483219014654 oxyanion hole (OAH) forming residues; other site 483219014655 trimer interface [polypeptide binding]; other site 483219014656 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 483219014657 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 483219014658 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 483219014659 antiporter inner membrane protein; Provisional; Region: PRK11670 483219014660 Domain of unknown function DUF59; Region: DUF59; pfam01883 483219014661 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 483219014662 Walker A motif; other site 483219014663 Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982 483219014664 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 483219014665 tandem repeat interface [polypeptide binding]; other site 483219014666 oligomer interface [polypeptide binding]; other site 483219014667 active site residues [active] 483219014668 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 483219014669 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 483219014670 tandem repeat interface [polypeptide binding]; other site 483219014671 oligomer interface [polypeptide binding]; other site 483219014672 active site residues [active] 483219014673 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 483219014674 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 483219014675 putative active site [active] 483219014676 Predicted acyl esterases [General function prediction only]; Region: COG2936 483219014677 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 483219014678 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 483219014679 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 483219014680 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 483219014681 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483219014682 putative substrate translocation pore; other site 483219014683 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 483219014684 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 483219014685 Myxococcales-restricted protein, TIGR02265 family; Region: Mxa_TIGR02265 483219014686 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 483219014687 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 483219014688 Poly(3-hydroxyalkanoate) synthetase [Lipid metabolism]; Region: PhaC; COG3243 483219014689 triacylglycerol lipase; Region: PLN02872 483219014690 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 483219014691 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 483219014692 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 483219014693 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 483219014694 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 483219014695 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 483219014696 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 483219014697 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 483219014698 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 483219014699 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 483219014700 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 483219014701 catalytic triad [active] 483219014702 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 483219014703 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 483219014704 active site 483219014705 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 483219014706 catalytic triad [active] 483219014707 dimer interface [polypeptide binding]; other site 483219014708 bile acid transporter; Region: bass; TIGR00841 483219014709 Sodium Bile acid symporter family; Region: SBF; cl17470 483219014710 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 483219014711 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 483219014712 RNase_H superfamily; Region: RNase_H_2; pfam13482 483219014713 active site 483219014714 substrate binding site [chemical binding]; other site 483219014715 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 483219014716 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 483219014717 ATP binding site [chemical binding]; other site 483219014718 putative Mg++ binding site [ion binding]; other site 483219014719 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 483219014720 nucleotide binding region [chemical binding]; other site 483219014721 ATP-binding site [chemical binding]; other site 483219014722 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 483219014723 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 483219014724 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 483219014725 transmembrane helices; other site 483219014726 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 483219014727 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219014728 binding surface 483219014729 Tetratricopeptide repeat; Region: TPR_16; pfam13432 483219014730 TPR motif; other site 483219014731 Potato leaf roll virus readthrough protein; Region: PLRV_ORF5; pfam01690 483219014732 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 483219014733 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 483219014734 ligand binding site [chemical binding]; other site 483219014735 flexible hinge region; other site 483219014736 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 483219014737 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 483219014738 ligand binding site [chemical binding]; other site 483219014739 flexible hinge region; other site 483219014740 HEAT repeats; Region: HEAT_2; pfam13646 483219014741 HEAT repeats; Region: HEAT_2; pfam13646 483219014742 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 483219014743 pseudouridine synthase; Region: TIGR00093 483219014744 active site 483219014745 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 483219014746 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 483219014747 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 483219014748 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 483219014749 active site 483219014750 HIGH motif; other site 483219014751 dimer interface [polypeptide binding]; other site 483219014752 KMSKS motif; other site 483219014753 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 483219014754 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 483219014755 active site 483219014756 Int/Topo IB signature motif; other site 483219014757 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 483219014758 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 483219014759 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 483219014760 Small hydrophilic plant seed protein; Region: LEA_5; pfam00477 483219014761 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 483219014762 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 483219014763 active site 483219014764 nucleophile elbow; other site 483219014765 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 483219014766 SnoaL-like domain; Region: SnoaL_3; pfam13474 483219014767 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 483219014768 active site 483219014769 Fatty acid desaturase; Region: FA_desaturase; pfam00487 483219014770 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 483219014771 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 483219014772 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 483219014773 iron-sulfur cluster [ion binding]; other site 483219014774 [2Fe-2S] cluster binding site [ion binding]; other site 483219014775 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219014776 AAA domain; Region: AAA_21; pfam13304 483219014777 Walker A/P-loop; other site 483219014778 ATP binding site [chemical binding]; other site 483219014779 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 483219014780 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 483219014781 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 483219014782 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 483219014783 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 483219014784 molybdopterin cofactor binding site; other site 483219014785 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 483219014786 4Fe-4S binding domain; Region: Fer4; pfam00037 483219014787 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 483219014788 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219014789 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219014790 dimer interface [polypeptide binding]; other site 483219014791 phosphorylation site [posttranslational modification] 483219014792 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219014793 ATP binding site [chemical binding]; other site 483219014794 Mg2+ binding site [ion binding]; other site 483219014795 G-X-G motif; other site 483219014796 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647 483219014797 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 483219014798 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 483219014799 putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12509 483219014800 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 483219014801 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 483219014802 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 483219014803 Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899 483219014804 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599 483219014805 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 483219014806 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 483219014807 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 483219014808 Subunit I/III interface [polypeptide binding]; other site 483219014809 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 483219014810 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 483219014811 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 483219014812 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 483219014813 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 483219014814 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 483219014815 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 483219014816 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 483219014817 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 483219014818 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 483219014819 molybdopterin cofactor binding site; other site 483219014820 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 483219014821 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 483219014822 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 483219014823 4Fe-4S binding domain; Region: Fer4; cl02805 483219014824 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 483219014825 heme-binding residues [chemical binding]; other site 483219014826 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 483219014827 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 483219014828 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 483219014829 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 483219014830 PAS fold; Region: PAS_4; pfam08448 483219014831 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 483219014832 putative active site [active] 483219014833 heme pocket [chemical binding]; other site 483219014834 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 483219014835 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219014836 dimer interface [polypeptide binding]; other site 483219014837 phosphorylation site [posttranslational modification] 483219014838 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219014839 ATP binding site [chemical binding]; other site 483219014840 Mg2+ binding site [ion binding]; other site 483219014841 G-X-G motif; other site 483219014842 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 483219014843 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219014844 active site 483219014845 phosphorylation site [posttranslational modification] 483219014846 intermolecular recognition site; other site 483219014847 dimerization interface [polypeptide binding]; other site 483219014848 Response regulator receiver domain; Region: Response_reg; pfam00072 483219014849 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219014850 active site 483219014851 phosphorylation site [posttranslational modification] 483219014852 intermolecular recognition site; other site 483219014853 dimerization interface [polypeptide binding]; other site 483219014854 benzoate transport; Region: 2A0115; TIGR00895 483219014855 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483219014856 putative substrate translocation pore; other site 483219014857 pyruvate carboxylase; Reviewed; Region: PRK12999 483219014858 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 483219014859 ATP-grasp domain; Region: ATP-grasp_4; cl17255 483219014860 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 483219014861 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 483219014862 active site 483219014863 catalytic residues [active] 483219014864 metal binding site [ion binding]; metal-binding site 483219014865 homodimer binding site [polypeptide binding]; other site 483219014866 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 483219014867 carboxyltransferase (CT) interaction site; other site 483219014868 biotinylation site [posttranslational modification]; other site 483219014869 Spore Coat Protein U domain; Region: SCPU; pfam05229 483219014870 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 483219014871 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 483219014872 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 483219014873 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 483219014874 Spore Coat Protein U domain; Region: SCPU; pfam05229 483219014875 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 483219014876 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 483219014877 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 483219014878 active site 483219014879 metal binding site [ion binding]; metal-binding site 483219014880 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 483219014881 maltose O-acetyltransferase; Provisional; Region: PRK10092 483219014882 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 483219014883 active site 483219014884 substrate binding site [chemical binding]; other site 483219014885 trimer interface [polypeptide binding]; other site 483219014886 CoA binding site [chemical binding]; other site 483219014887 Protein of unknown function (DUF998); Region: DUF998; pfam06197 483219014888 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 483219014889 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 483219014890 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219014891 binding surface 483219014892 TPR repeat; Region: TPR_11; pfam13414 483219014893 TPR motif; other site 483219014894 Tetratricopeptide repeat; Region: TPR_12; pfam13424 483219014895 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 483219014896 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 483219014897 active site 483219014898 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 483219014899 MutS domain I; Region: MutS_I; pfam01624 483219014900 MutS domain II; Region: MutS_II; pfam05188 483219014901 MutS domain III; Region: MutS_III; pfam05192 483219014902 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 483219014903 Walker A/P-loop; other site 483219014904 ATP binding site [chemical binding]; other site 483219014905 Q-loop/lid; other site 483219014906 ABC transporter signature motif; other site 483219014907 Walker B; other site 483219014908 D-loop; other site 483219014909 H-loop/switch region; other site 483219014910 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 483219014911 Transglutaminase-like superfamily; Region: Transglut_core; cl17362 483219014912 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 483219014913 ABC1 family; Region: ABC1; pfam03109 483219014914 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 483219014915 active site 483219014916 ATP binding site [chemical binding]; other site 483219014917 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 483219014918 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 483219014919 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 483219014920 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 483219014921 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 483219014922 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD_like; cd08296 483219014923 putative NAD(P) binding site [chemical binding]; other site 483219014924 putative substrate binding site [chemical binding]; other site 483219014925 catalytic Zn binding site [ion binding]; other site 483219014926 structural Zn binding site [ion binding]; other site 483219014927 hypothetical protein; Provisional; Region: PRK06834 483219014928 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 483219014929 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 483219014930 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 483219014931 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 483219014932 HlyD family secretion protein; Region: HlyD_3; pfam13437 483219014933 Outer membrane efflux protein; Region: OEP; pfam02321 483219014934 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 483219014935 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 483219014936 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 483219014937 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 483219014938 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 483219014939 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219014940 Walker A/P-loop; other site 483219014941 ATP binding site [chemical binding]; other site 483219014942 Q-loop/lid; other site 483219014943 ABC transporter signature motif; other site 483219014944 Walker B; other site 483219014945 D-loop; other site 483219014946 Permease; Region: Permease; pfam02405 483219014947 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 483219014948 Permease; Region: Permease; pfam02405 483219014949 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 483219014950 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219014951 Walker A/P-loop; other site 483219014952 ATP binding site [chemical binding]; other site 483219014953 Q-loop/lid; other site 483219014954 ABC transporter signature motif; other site 483219014955 Walker B; other site 483219014956 D-loop; other site 483219014957 H-loop/switch region; other site 483219014958 mce related protein; Region: MCE; pfam02470 483219014959 T-complex protein 11; Region: Tcp11; pfam05794 483219014960 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219014961 AAA domain; Region: AAA_21; pfam13304 483219014962 Q-loop/lid; other site 483219014963 ABC transporter signature motif; other site 483219014964 Walker B; other site 483219014965 D-loop; other site 483219014966 H-loop/switch region; other site 483219014967 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 483219014968 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 483219014969 ATP binding site [chemical binding]; other site 483219014970 putative Mg++ binding site [ion binding]; other site 483219014971 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 483219014972 nucleotide binding region [chemical binding]; other site 483219014973 ATP-binding site [chemical binding]; other site 483219014974 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 483219014975 RNA binding site [nucleotide binding]; other site 483219014976 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 483219014977 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 483219014978 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 483219014979 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 483219014980 putative active site [active] 483219014981 nucleotide binding site [chemical binding]; other site 483219014982 nudix motif; other site 483219014983 putative metal binding site [ion binding]; other site 483219014984 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 483219014985 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 483219014986 active site 483219014987 dimer interface [polypeptide binding]; other site 483219014988 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 483219014989 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 483219014990 active site 483219014991 FMN binding site [chemical binding]; other site 483219014992 substrate binding site [chemical binding]; other site 483219014993 3Fe-4S cluster binding site [ion binding]; other site 483219014994 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 483219014995 domain interface; other site 483219014996 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 483219014997 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 483219014998 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 483219014999 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 483219015000 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 483219015001 P-loop; other site 483219015002 Magnesium ion binding site [ion binding]; other site 483219015003 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 483219015004 Magnesium ion binding site [ion binding]; other site 483219015005 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 483219015006 Leucine rich repeat; Region: LRR_8; pfam13855 483219015007 DTW domain; Region: DTW; cl01221 483219015008 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 483219015009 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 483219015010 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 483219015011 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 483219015012 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 483219015013 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219015014 Walker A motif; other site 483219015015 ATP binding site [chemical binding]; other site 483219015016 Walker B motif; other site 483219015017 arginine finger; other site 483219015018 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 483219015019 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219015020 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219015021 active site 483219015022 ATP binding site [chemical binding]; other site 483219015023 substrate binding site [chemical binding]; other site 483219015024 activation loop (A-loop); other site 483219015025 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 483219015026 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 483219015027 phosphopeptide binding site; other site 483219015028 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 483219015029 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 483219015030 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 483219015031 cyclase homology domain; Region: CHD; cd07302 483219015032 nucleotidyl binding site; other site 483219015033 metal binding site [ion binding]; metal-binding site 483219015034 dimer interface [polypeptide binding]; other site 483219015035 Uncharacterized conserved protein [Function unknown]; Region: COG0585 483219015036 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 483219015037 active site 483219015038 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 483219015039 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 483219015040 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 483219015041 DNA binding residues [nucleotide binding] 483219015042 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 483219015043 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 483219015044 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 483219015045 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 483219015046 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 483219015047 classical (c) SDRs; Region: SDR_c; cd05233 483219015048 NAD(P) binding site [chemical binding]; other site 483219015049 active site 483219015050 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 483219015051 Ligand Binding Site [chemical binding]; other site 483219015052 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991 483219015053 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 483219015054 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 483219015055 putative acyl-acceptor binding pocket; other site 483219015056 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 483219015057 putative catalytic site [active] 483219015058 putative metal binding site [ion binding]; other site 483219015059 putative phosphate binding site [ion binding]; other site 483219015060 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 483219015061 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 483219015062 Lamin Tail Domain; Region: LTD; pfam00932 483219015063 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 483219015064 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 483219015065 GAF domain; Region: GAF; pfam01590 483219015066 GAF domain; Region: GAF_2; pfam13185 483219015067 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 483219015068 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219015069 putative active site [active] 483219015070 heme pocket [chemical binding]; other site 483219015071 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219015072 phosphorylation site [posttranslational modification] 483219015073 dimer interface [polypeptide binding]; other site 483219015074 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219015075 ATP binding site [chemical binding]; other site 483219015076 Mg2+ binding site [ion binding]; other site 483219015077 G-X-G motif; other site 483219015078 WbqC-like protein family; Region: WbqC; pfam08889 483219015079 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 483219015080 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 483219015081 active site 483219015082 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 483219015083 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 483219015084 Coenzyme A binding pocket [chemical binding]; other site 483219015085 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 483219015086 Kelch domain; Region: Kelch; smart00612 483219015087 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 483219015088 Kelch domain; Region: Kelch; smart00612 483219015089 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 483219015090 Kelch domain; Region: Kelch; smart00612 483219015091 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 483219015092 Kelch motif; Region: Kelch_1; pfam01344 483219015093 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 483219015094 Kelch domain; Region: Kelch; smart00612 483219015095 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 483219015096 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 483219015097 putative active site [active] 483219015098 putative PHP Thumb interface [polypeptide binding]; other site 483219015099 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 483219015100 generic binding surface I; other site 483219015101 generic binding surface II; other site 483219015102 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 483219015103 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 483219015104 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 483219015105 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 483219015106 von Willebrand factor type A domain; Region: VWA_2; pfam13519 483219015107 metal ion-dependent adhesion site (MIDAS); other site 483219015108 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 483219015109 metal ion-dependent adhesion site (MIDAS); other site 483219015110 Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842 483219015111 active site 483219015112 catalytic triad [active] 483219015113 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 483219015114 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 483219015115 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 483219015116 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 483219015117 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 483219015118 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 483219015119 NAD(P) binding site [chemical binding]; other site 483219015120 active site 483219015121 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 483219015122 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 483219015123 phosphopeptide binding site; other site 483219015124 DNA Polymerase Y-family; Region: PolY_like; cd03468 483219015125 active site 483219015126 DNA binding site [nucleotide binding] 483219015127 recA bacterial DNA recombination protein; Region: RecA; cl17211 483219015128 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 483219015129 metal ion-dependent adhesion site (MIDAS); other site 483219015130 Found in ATP-dependent protease La (LON); Region: LON; smart00464 483219015131 ATP-dependent protease La; Region: lon; TIGR00763 483219015132 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219015133 Walker A motif; other site 483219015134 ATP binding site [chemical binding]; other site 483219015135 Walker B motif; other site 483219015136 arginine finger; other site 483219015137 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 483219015138 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 483219015139 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 483219015140 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 483219015141 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 483219015142 active site 483219015143 metal binding site [ion binding]; metal-binding site 483219015144 Condensation domain; Region: Condensation; pfam00668 483219015145 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219015146 Condensation domain; Region: Condensation; pfam00668 483219015147 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219015148 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219015149 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 483219015150 acyl-activating enzyme (AAE) consensus motif; other site 483219015151 AMP binding site [chemical binding]; other site 483219015152 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219015153 Condensation domain; Region: Condensation; pfam00668 483219015154 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219015155 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219015156 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 483219015157 acyl-activating enzyme (AAE) consensus motif; other site 483219015158 AMP binding site [chemical binding]; other site 483219015159 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219015160 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 483219015161 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219015162 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 483219015163 acyl-activating enzyme (AAE) consensus motif; other site 483219015164 AMP binding site [chemical binding]; other site 483219015165 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219015166 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 483219015167 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 483219015168 active site 483219015169 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 483219015170 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 483219015171 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219015172 Condensation domain; Region: Condensation; pfam00668 483219015173 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219015174 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219015175 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 483219015176 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 483219015177 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 483219015178 Condensation domain; Region: Condensation; pfam00668 483219015179 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219015180 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219015181 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 483219015182 acyl-activating enzyme (AAE) consensus motif; other site 483219015183 AMP binding site [chemical binding]; other site 483219015184 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219015185 Condensation domain; Region: Condensation; pfam00668 483219015186 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 483219015187 acyl-CoA synthetase; Validated; Region: PRK05850 483219015188 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 483219015189 acyl-activating enzyme (AAE) consensus motif; other site 483219015190 active site 483219015191 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219015192 Condensation domain; Region: Condensation; pfam00668 483219015193 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219015194 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219015195 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 483219015196 acyl-activating enzyme (AAE) consensus motif; other site 483219015197 AMP binding site [chemical binding]; other site 483219015198 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219015199 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 483219015200 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 483219015201 active site 483219015202 catalytic tetrad [active] 483219015203 Domain of unknown function (DUF4130; Region: DUF4130; cl14836 483219015204 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 483219015205 Fe-S cluster binding site [ion binding]; other site 483219015206 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 483219015207 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 483219015208 phosphopeptide binding site; other site 483219015209 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 483219015210 Domain of unknown function (DUF3943); Region: DUF3943; pfam13084 483219015211 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 483219015212 active site 483219015213 catalytic site [active] 483219015214 putative metal binding site [ion binding]; other site 483219015215 Beta/Gamma crystallin; Region: Crystall; cl02528 483219015216 phosphofructokinase; Region: PFK_mixed; TIGR02483 483219015217 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 483219015218 active site 483219015219 ADP/pyrophosphate binding site [chemical binding]; other site 483219015220 dimerization interface [polypeptide binding]; other site 483219015221 allosteric effector site; other site 483219015222 fructose-1,6-bisphosphate binding site; other site 483219015223 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 483219015224 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219015225 active site 483219015226 ATP binding site [chemical binding]; other site 483219015227 substrate binding site [chemical binding]; other site 483219015228 activation loop (A-loop); other site 483219015229 PEGA domain; Region: PEGA; pfam08308 483219015230 Tetratricopeptide repeat; Region: TPR_2; pfam07719 483219015231 FHA domain; Region: FHA; pfam00498 483219015232 phosphopeptide binding site; other site 483219015233 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 483219015234 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 483219015235 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219015236 Walker A motif; other site 483219015237 ATP binding site [chemical binding]; other site 483219015238 Walker B motif; other site 483219015239 arginine finger; other site 483219015240 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 483219015241 WAP-type (Whey Acidic Protein) 'four-disulfide core' Region: WAP; pfam00095 483219015242 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 483219015243 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 483219015244 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219015245 ATP binding site [chemical binding]; other site 483219015246 Mg2+ binding site [ion binding]; other site 483219015247 G-X-G motif; other site 483219015248 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 483219015249 ATP binding site [chemical binding]; other site 483219015250 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 483219015251 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 483219015252 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 483219015253 putative NAD(P) binding site [chemical binding]; other site 483219015254 active site 483219015255 putative substrate binding site [chemical binding]; other site 483219015256 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 483219015257 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 483219015258 putative acyl-acceptor binding pocket; other site 483219015259 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 483219015260 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 483219015261 phosphopeptide binding site; other site 483219015262 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 483219015263 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 483219015264 metal binding site [ion binding]; metal-binding site 483219015265 active site 483219015266 I-site; other site 483219015267 Protein of unknown function (DUF721); Region: DUF721; pfam05258 483219015268 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 483219015269 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 483219015270 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 483219015271 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 483219015272 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 483219015273 N-acetyl-D-glucosamine binding site [chemical binding]; other site 483219015274 catalytic residue [active] 483219015275 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 483219015276 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 483219015277 C-terminal domain interface [polypeptide binding]; other site 483219015278 GSH binding site (G-site) [chemical binding]; other site 483219015279 dimer interface [polypeptide binding]; other site 483219015280 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 483219015281 N-terminal domain interface [polypeptide binding]; other site 483219015282 dimer interface [polypeptide binding]; other site 483219015283 substrate binding pocket (H-site) [chemical binding]; other site 483219015284 cytidylate kinase; Provisional; Region: cmk; PRK00023 483219015285 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 483219015286 CMP-binding site; other site 483219015287 The sites determining sugar specificity; other site 483219015288 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 483219015289 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 483219015290 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483219015291 homodimer interface [polypeptide binding]; other site 483219015292 catalytic residue [active] 483219015293 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 483219015294 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 483219015295 TPR repeat; Region: TPR_11; pfam13414 483219015296 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219015297 binding surface 483219015298 TPR motif; other site 483219015299 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 483219015300 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 483219015301 DTAP/Switch II; other site 483219015302 Switch I; other site 483219015303 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 483219015304 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 483219015305 P loop; other site 483219015306 Nucleotide binding site [chemical binding]; other site 483219015307 DTAP/Switch II; other site 483219015308 Switch I; other site 483219015309 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 483219015310 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219015311 active site 483219015312 phosphorylation site [posttranslational modification] 483219015313 intermolecular recognition site; other site 483219015314 dimerization interface [polypeptide binding]; other site 483219015315 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219015316 Walker A motif; other site 483219015317 ATP binding site [chemical binding]; other site 483219015318 Walker B motif; other site 483219015319 arginine finger; other site 483219015320 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 483219015321 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219015322 phosphorylation site [posttranslational modification] 483219015323 dimer interface [polypeptide binding]; other site 483219015324 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 483219015325 catalytic motif [active] 483219015326 Zn binding site [ion binding]; other site 483219015327 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 483219015328 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 483219015329 PrkA AAA domain; Region: AAA_PrkA; smart00763 483219015330 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 483219015331 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 483219015332 MreB/Mbl protein; Region: MreB_Mbl; pfam06723 483219015333 nucleotide binding site [chemical binding]; other site 483219015334 potential frameshift: common BLAST hit: gi|108762189|ref|YP_632227.1| serine/threonine protein kinase/response regulator/adenylate 483219015335 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 483219015336 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 483219015337 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 483219015338 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 483219015339 putative binding surface; other site 483219015340 active site 483219015341 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 483219015342 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219015343 ATP binding site [chemical binding]; other site 483219015344 Mg2+ binding site [ion binding]; other site 483219015345 G-X-G motif; other site 483219015346 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 483219015347 CHASE3 domain; Region: CHASE3; pfam05227 483219015348 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219015349 dimerization interface [polypeptide binding]; other site 483219015350 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 483219015351 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 483219015352 dimer interface [polypeptide binding]; other site 483219015353 putative CheW interface [polypeptide binding]; other site 483219015354 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 483219015355 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 483219015356 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 483219015357 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 483219015358 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 483219015359 Cupin-like domain; Region: Cupin_8; pfam13621 483219015360 Arginase family; Region: Arginase; pfam00491 483219015361 agmatinase; Region: agmatinase; TIGR01230 483219015362 active site 483219015363 metal binding site [ion binding]; metal-binding site 483219015364 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 483219015365 active site 483219015366 metal binding site [ion binding]; metal-binding site 483219015367 Cupin-like domain; Region: Cupin_8; pfam13621 483219015368 agmatinase; Region: agmatinase; TIGR01230 483219015369 Arginase family; Region: Arginase; pfam00491 483219015370 active site 483219015371 metal binding site [ion binding]; metal-binding site 483219015372 agmatinase; Region: agmatinase; TIGR01230 483219015373 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 483219015374 active site 483219015375 metal binding site [ion binding]; metal-binding site 483219015376 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 483219015377 putative acyl-acceptor binding pocket; other site 483219015378 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 483219015379 FeS/SAM binding site; other site 483219015380 Radical SAM superfamily; Region: Radical_SAM; pfam04055 483219015381 phytoene desaturase; Region: crtI_fam; TIGR02734 483219015382 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 483219015383 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219015384 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 483219015385 active site 483219015386 substrate binding site [chemical binding]; other site 483219015387 activation loop (A-loop); other site 483219015388 AAA ATPase domain; Region: AAA_16; pfam13191 483219015389 Predicted ATPase [General function prediction only]; Region: COG3899 483219015390 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 483219015391 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 483219015392 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219015393 ATP binding site [chemical binding]; other site 483219015394 Mg2+ binding site [ion binding]; other site 483219015395 G-X-G motif; other site 483219015396 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 483219015397 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 483219015398 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 483219015399 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219015400 Walker A motif; other site 483219015401 ATP binding site [chemical binding]; other site 483219015402 Walker B motif; other site 483219015403 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 483219015404 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 483219015405 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 483219015406 active site 483219015407 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 483219015408 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 483219015409 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 483219015410 Ligand Binding Site [chemical binding]; other site 483219015411 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 483219015412 ligand-binding site [chemical binding]; other site 483219015413 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 483219015414 MPN+ (JAMM) motif; other site 483219015415 Zinc-binding site [ion binding]; other site 483219015416 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 483219015417 ATP binding site [chemical binding]; other site 483219015418 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 483219015419 MoaE interaction surface [polypeptide binding]; other site 483219015420 thiocarboxylated glycine; other site 483219015421 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 483219015422 CPxP motif; other site 483219015423 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 483219015424 ATP binding site [chemical binding]; other site 483219015425 substrate interface [chemical binding]; other site 483219015426 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 483219015427 Histidine kinase; Region: HisKA_3; pfam07730 483219015428 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219015429 ATP binding site [chemical binding]; other site 483219015430 Mg2+ binding site [ion binding]; other site 483219015431 G-X-G motif; other site 483219015432 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 483219015433 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219015434 active site 483219015435 phosphorylation site [posttranslational modification] 483219015436 intermolecular recognition site; other site 483219015437 dimerization interface [polypeptide binding]; other site 483219015438 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 483219015439 DNA binding residues [nucleotide binding] 483219015440 dimerization interface [polypeptide binding]; other site 483219015441 potential frameshift: common BLAST hit: gi|108760388|ref|YP_632251.1| putative glycosyl hydrolase 483219015442 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 483219015443 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 483219015444 Walker A/P-loop; other site 483219015445 ATP binding site [chemical binding]; other site 483219015446 Q-loop/lid; other site 483219015447 ABC transporter signature motif; other site 483219015448 Walker B; other site 483219015449 D-loop; other site 483219015450 H-loop/switch region; other site 483219015451 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 483219015452 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 483219015453 Zn binding site [ion binding]; other site 483219015454 Protein of unknown function (DUF2378); Region: DUF2378; pfam09536 483219015455 Protein of unknown function (DUF2378); Region: DUF2378; cl15288 483219015456 Helix-turn-helix domain; Region: HTH_18; pfam12833 483219015457 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 483219015458 potential frameshift: common BLAST hit: gi|108759995|ref|YP_632255.1| polyketide synthase type I 483219015459 Condensation domain; Region: Condensation; pfam00668 483219015460 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219015461 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219015462 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 483219015463 acyl-activating enzyme (AAE) consensus motif; other site 483219015464 AMP binding site [chemical binding]; other site 483219015465 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219015466 S-adenosylmethionine binding site [chemical binding]; other site 483219015467 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 483219015468 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219015469 Condensation domain; Region: Condensation; pfam00668 483219015470 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219015471 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219015472 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 483219015473 acyl-activating enzyme (AAE) consensus motif; other site 483219015474 AMP binding site [chemical binding]; other site 483219015475 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219015476 Condensation domain; Region: Condensation; pfam00668 483219015477 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219015478 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 483219015479 Condensation domain; Region: Condensation; pfam00668 483219015480 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219015481 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 483219015482 acyl-activating enzyme (AAE) consensus motif; other site 483219015483 AMP binding site [chemical binding]; other site 483219015484 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219015485 Condensation domain; Region: Condensation; pfam00668 483219015486 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219015487 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219015488 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 483219015489 acyl-activating enzyme (AAE) consensus motif; other site 483219015490 AMP binding site [chemical binding]; other site 483219015491 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219015492 Condensation domain; Region: Condensation; pfam00668 483219015493 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219015494 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219015495 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 483219015496 acyl-activating enzyme (AAE) consensus motif; other site 483219015497 AMP binding site [chemical binding]; other site 483219015498 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219015499 Condensation domain; Region: Condensation; pfam00668 483219015500 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219015501 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219015502 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 483219015503 acyl-activating enzyme (AAE) consensus motif; other site 483219015504 AMP binding site [chemical binding]; other site 483219015505 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219015506 Thioesterase domain; Region: Thioesterase; pfam00975 483219015507 Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027 483219015508 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 483219015509 DEAD-like helicases superfamily; Region: DEXDc; smart00487 483219015510 ATP binding site [chemical binding]; other site 483219015511 Mg++ binding site [ion binding]; other site 483219015512 motif III; other site 483219015513 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 483219015514 nucleotide binding region [chemical binding]; other site 483219015515 ATP-binding site [chemical binding]; other site 483219015516 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 483219015517 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 483219015518 ligand binding site [chemical binding]; other site 483219015519 flexible hinge region; other site 483219015520 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 483219015521 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 483219015522 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 483219015523 putative active site [active] 483219015524 putative metal binding site [ion binding]; other site 483219015525 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 483219015526 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 483219015527 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 483219015528 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 483219015529 DNA binding residues [nucleotide binding] 483219015530 Antirepressor CarS; Region: CarS; cd12840 483219015531 putative repressor interaction site [polypeptide binding]; other site 483219015532 Domain of unknown function DUF20; Region: UPF0118; pfam01594 483219015533 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 483219015534 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 483219015535 homodimer interface [polypeptide binding]; other site 483219015536 homotetramer interface [polypeptide binding]; other site 483219015537 active site pocket [active] 483219015538 cleavage site 483219015539 D-alanyl-alanine synthetase A; Provisional; Region: PRK14571 483219015540 ATP-grasp domain; Region: ATP-grasp_4; cl17255 483219015541 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 483219015542 D-alanine--D-alanine ligase; Region: D_ala_D_alaTIGR; TIGR01205 483219015543 ATP-grasp domain; Region: ATP-grasp_4; cl17255 483219015544 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 483219015545 dimer interface [polypeptide binding]; other site 483219015546 active site 483219015547 Schiff base residues; other site 483219015548 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 483219015549 anchored repeat-type ABC transporter, ATP-binding subunit; Region: anch_rpt_ABC; TIGR03771 483219015550 Walker A/P-loop; other site 483219015551 ATP binding site [chemical binding]; other site 483219015552 Q-loop/lid; other site 483219015553 ABC transporter signature motif; other site 483219015554 Walker B; other site 483219015555 D-loop; other site 483219015556 H-loop/switch region; other site 483219015557 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219015558 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 483219015559 Walker A motif; other site 483219015560 ATP binding site [chemical binding]; other site 483219015561 Walker B motif; other site 483219015562 arginine finger; other site 483219015563 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 483219015564 transmembrane helices; other site 483219015565 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 483219015566 Prostaglandin dehydrogenases; Region: PGDH; cd05288 483219015567 NAD(P) binding site [chemical binding]; other site 483219015568 substrate binding site [chemical binding]; other site 483219015569 dimer interface [polypeptide binding]; other site 483219015570 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998 483219015571 Transcriptional regulator [Transcription]; Region: LysR; COG0583 483219015572 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 483219015573 LysR substrate binding domain; Region: LysR_substrate; pfam03466 483219015574 dimerization interface [polypeptide binding]; other site 483219015575 Pirin-related protein [General function prediction only]; Region: COG1741 483219015576 Pirin; Region: Pirin; pfam02678 483219015577 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 483219015578 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 483219015579 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 483219015580 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 483219015581 Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226 483219015582 TrkA-N domain; Region: TrkA_N; pfam02254 483219015583 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 483219015584 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 483219015585 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 483219015586 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 483219015587 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 483219015588 DDE superfamily endonuclease; Region: DDE_3; pfam13358 483219015589 Helix-turn-helix domain; Region: HTH_28; pfam13518 483219015590 Winged helix-turn helix; Region: HTH_29; pfam13551 483219015591 Winged helix-turn helix; Region: HTH_33; pfam13592 483219015592 Transposase, Mutator family; Region: Transposase_mut; pfam00872 483219015593 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 483219015594 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 483219015595 Minor capsid protein VI; Region: MCPVI; pfam02993 483219015596 photolyase PhrII; Region: phr2; TIGR00591 483219015597 DNA photolyase; Region: DNA_photolyase; pfam00875 483219015598 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865 483219015599 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 483219015600 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 483219015601 Tetratricopeptide repeat; Region: TPR_16; pfam13432 483219015602 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219015603 TPR motif; other site 483219015604 binding surface 483219015605 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219015606 binding surface 483219015607 Tetratricopeptide repeat; Region: TPR_16; pfam13432 483219015608 TPR motif; other site 483219015609 TPR repeat; Region: TPR_11; pfam13414 483219015610 CheB methylesterase; Region: CheB_methylest; pfam01339 483219015611 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 483219015612 putative binding surface; other site 483219015613 active site 483219015614 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219015615 ATP binding site [chemical binding]; other site 483219015616 Mg2+ binding site [ion binding]; other site 483219015617 G-X-G motif; other site 483219015618 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 483219015619 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 483219015620 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219015621 active site 483219015622 phosphorylation site [posttranslational modification] 483219015623 intermolecular recognition site; other site 483219015624 dimerization interface [polypeptide binding]; other site 483219015625 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 483219015626 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 483219015627 dimer interface [polypeptide binding]; other site 483219015628 putative CheW interface [polypeptide binding]; other site 483219015629 Two component signalling adaptor domain; Region: CheW; smart00260 483219015630 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 483219015631 putative CheA interaction surface; other site 483219015632 Response regulator receiver domain; Region: Response_reg; pfam00072 483219015633 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219015634 active site 483219015635 phosphorylation site [posttranslational modification] 483219015636 intermolecular recognition site; other site 483219015637 dimerization interface [polypeptide binding]; other site 483219015638 Response regulator receiver domain; Region: Response_reg; pfam00072 483219015639 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219015640 active site 483219015641 phosphorylation site [posttranslational modification] 483219015642 intermolecular recognition site; other site 483219015643 dimerization interface [polypeptide binding]; other site 483219015644 Radical SAM superfamily; Region: Radical_SAM; pfam04055 483219015645 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 483219015646 FeS/SAM binding site; other site 483219015647 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 483219015648 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 483219015649 hexamer interface [polypeptide binding]; other site 483219015650 ligand binding site [chemical binding]; other site 483219015651 putative active site [active] 483219015652 NAD(P) binding site [chemical binding]; other site 483219015653 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 483219015654 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 483219015655 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 483219015656 DNA binding residues [nucleotide binding] 483219015657 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 483219015658 Response regulator receiver domain; Region: Response_reg; pfam00072 483219015659 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219015660 active site 483219015661 phosphorylation site [posttranslational modification] 483219015662 intermolecular recognition site; other site 483219015663 dimerization interface [polypeptide binding]; other site 483219015664 pantothenate kinase; Reviewed; Region: PRK13321 483219015665 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 483219015666 Biotin operon repressor [Transcription]; Region: BirA; COG1654 483219015667 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 483219015668 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 483219015669 HEAT repeats; Region: HEAT_2; pfam13646 483219015670 Restriction endonuclease; Region: Mrr_cat; pfam04471 483219015671 PQQ-like domain; Region: PQQ_2; pfam13360 483219015672 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 483219015673 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 483219015674 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 483219015675 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 483219015676 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 483219015677 Sugar specificity; other site 483219015678 Pyrimidine base specificity; other site 483219015679 ATP-binding site [chemical binding]; other site 483219015680 Protein of unknown function (DUF692); Region: DUF692; cl01263 483219015681 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 483219015682 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 483219015683 Coenzyme A binding pocket [chemical binding]; other site 483219015684 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 483219015685 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219015686 active site 483219015687 phosphorylation site [posttranslational modification] 483219015688 intermolecular recognition site; other site 483219015689 dimerization interface [polypeptide binding]; other site 483219015690 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 483219015691 DNA binding site [nucleotide binding] 483219015692 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219015693 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219015694 dimer interface [polypeptide binding]; other site 483219015695 phosphorylation site [posttranslational modification] 483219015696 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219015697 ATP binding site [chemical binding]; other site 483219015698 Mg2+ binding site [ion binding]; other site 483219015699 G-X-G motif; other site 483219015700 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 483219015701 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 483219015702 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 483219015703 dimer interface [polypeptide binding]; other site 483219015704 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483219015705 catalytic residue [active] 483219015706 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 483219015707 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 483219015708 FtsX-like permease family; Region: FtsX; pfam02687 483219015709 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 483219015710 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 483219015711 FtsX-like permease family; Region: FtsX; pfam02687 483219015712 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 483219015713 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 483219015714 Walker A/P-loop; other site 483219015715 ATP binding site [chemical binding]; other site 483219015716 Q-loop/lid; other site 483219015717 ABC transporter signature motif; other site 483219015718 Walker B; other site 483219015719 D-loop; other site 483219015720 H-loop/switch region; other site 483219015721 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 483219015722 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 483219015723 HlyD family secretion protein; Region: HlyD_3; pfam13437 483219015724 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 483219015725 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219015726 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 483219015727 Walker A motif; other site 483219015728 ATP binding site [chemical binding]; other site 483219015729 Walker B motif; other site 483219015730 arginine finger; other site 483219015731 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219015732 Walker A motif; other site 483219015733 ATP binding site [chemical binding]; other site 483219015734 Walker B motif; other site 483219015735 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 483219015736 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 483219015737 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 483219015738 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 483219015739 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 483219015740 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 483219015741 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 483219015742 active site 483219015743 (T/H)XGH motif; other site 483219015744 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 483219015745 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 483219015746 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 483219015747 cyclase homology domain; Region: CHD; cd07302 483219015748 nucleotidyl binding site; other site 483219015749 metal binding site [ion binding]; metal-binding site 483219015750 dimer interface [polypeptide binding]; other site 483219015751 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219015752 binding surface 483219015753 TPR motif; other site 483219015754 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 483219015755 MutS domain III; Region: MutS_III; pfam05192 483219015756 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219015757 Walker A/P-loop; other site 483219015758 ATP binding site [chemical binding]; other site 483219015759 Q-loop/lid; other site 483219015760 ABC transporter signature motif; other site 483219015761 Walker B; other site 483219015762 D-loop; other site 483219015763 H-loop/switch region; other site 483219015764 Smr domain; Region: Smr; pfam01713 483219015765 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 483219015766 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 483219015767 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219015768 active site 483219015769 phosphorylation site [posttranslational modification] 483219015770 intermolecular recognition site; other site 483219015771 dimerization interface [polypeptide binding]; other site 483219015772 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219015773 Walker A motif; other site 483219015774 ATP binding site [chemical binding]; other site 483219015775 Walker B motif; other site 483219015776 arginine finger; other site 483219015777 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 483219015778 sensor protein ZraS; Provisional; Region: PRK10364 483219015779 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219015780 dimer interface [polypeptide binding]; other site 483219015781 phosphorylation site [posttranslational modification] 483219015782 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219015783 ATP binding site [chemical binding]; other site 483219015784 Mg2+ binding site [ion binding]; other site 483219015785 G-X-G motif; other site 483219015786 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 483219015787 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 483219015788 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 483219015789 Walker A/P-loop; other site 483219015790 ATP binding site [chemical binding]; other site 483219015791 Q-loop/lid; other site 483219015792 ABC transporter signature motif; other site 483219015793 Walker B; other site 483219015794 D-loop; other site 483219015795 H-loop/switch region; other site 483219015796 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 483219015797 HlyD family secretion protein; Region: HlyD_3; pfam13437 483219015798 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 483219015799 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 483219015800 FtsX-like permease family; Region: FtsX; pfam02687 483219015801 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 483219015802 intracellular protease, PfpI family; Region: PfpI; TIGR01382 483219015803 proposed catalytic triad [active] 483219015804 conserved cys residue [active] 483219015805 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219015806 active site 483219015807 phosphorylation site [posttranslational modification] 483219015808 intermolecular recognition site; other site 483219015809 dimerization interface [polypeptide binding]; other site 483219015810 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219015811 ATP binding site [chemical binding]; other site 483219015812 Mg2+ binding site [ion binding]; other site 483219015813 G-X-G motif; other site 483219015814 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 483219015815 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 483219015816 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 483219015817 NAD(P) binding site [chemical binding]; other site 483219015818 active site 483219015819 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 483219015820 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 483219015821 putative active site [active] 483219015822 putative metal binding site [ion binding]; other site 483219015823 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219015824 binding surface 483219015825 TPR motif; other site 483219015826 TPR repeat; Region: TPR_11; pfam13414 483219015827 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 483219015828 Protein of unknown function (DUF3185); Region: DUF3185; pfam11381 483219015829 ribonuclease R; Region: RNase_R; TIGR02063 483219015830 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 483219015831 RNB domain; Region: RNB; pfam00773 483219015832 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 483219015833 RNA binding site [nucleotide binding]; other site 483219015834 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 483219015835 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 483219015836 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 483219015837 dimer interface [polypeptide binding]; other site 483219015838 putative functional site; other site 483219015839 putative MPT binding site; other site 483219015840 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 483219015841 dimerization interface [polypeptide binding]; other site 483219015842 active site 483219015843 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 483219015844 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 483219015845 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 483219015846 nudix motif; other site 483219015847 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 483219015848 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 483219015849 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 483219015850 E3 interaction surface; other site 483219015851 lipoyl attachment site [posttranslational modification]; other site 483219015852 e3 binding domain; Region: E3_binding; pfam02817 483219015853 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 483219015854 lipoyl synthase; Provisional; Region: PRK05481 483219015855 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 483219015856 FeS/SAM binding site; other site 483219015857 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 483219015858 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 483219015859 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 483219015860 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 483219015861 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 483219015862 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 483219015863 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 483219015864 metal binding site [ion binding]; metal-binding site 483219015865 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 483219015866 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 483219015867 active site 483219015868 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 483219015869 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 483219015870 substrate binding site [chemical binding]; other site 483219015871 glutamase interaction surface [polypeptide binding]; other site 483219015872 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cl00341 483219015873 putative active site pocket [active] 483219015874 4-fold oligomerization interface [polypeptide binding]; other site 483219015875 metal binding residues [ion binding]; metal-binding site 483219015876 3-fold/trimer interface [polypeptide binding]; other site 483219015877 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 483219015878 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 483219015879 catalytic residues [active] 483219015880 Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118 483219015881 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 483219015882 putative active site [active] 483219015883 oxyanion strand; other site 483219015884 catalytic triad [active] 483219015885 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 483219015886 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 483219015887 pyridoxal 5'-phosphate binding site [chemical binding]; other site 483219015888 homodimer interface [polypeptide binding]; other site 483219015889 catalytic residue [active] 483219015890 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 483219015891 histidinol dehydrogenase; Region: hisD; TIGR00069 483219015892 NAD binding site [chemical binding]; other site 483219015893 dimerization interface [polypeptide binding]; other site 483219015894 product binding site; other site 483219015895 substrate binding site [chemical binding]; other site 483219015896 zinc binding site [ion binding]; other site 483219015897 catalytic residues [active] 483219015898 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 483219015899 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 483219015900 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 483219015901 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 483219015902 hydroxyglutarate oxidase; Provisional; Region: PRK11728 483219015903 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 483219015904 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219015905 active site 483219015906 phosphorylation site [posttranslational modification] 483219015907 intermolecular recognition site; other site 483219015908 dimerization interface [polypeptide binding]; other site 483219015909 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 483219015910 Zn2+ binding site [ion binding]; other site 483219015911 Mg2+ binding site [ion binding]; other site 483219015912 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 483219015913 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 483219015914 FeS/SAM binding site; other site 483219015915 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 483219015916 Tic20-like protein; Region: Tic20; pfam09685 483219015917 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 483219015918 ThiC-associated domain; Region: ThiC-associated; pfam13667 483219015919 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 483219015920 FOG: CBS domain [General function prediction only]; Region: COG0517 483219015921 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 483219015922 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 483219015923 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 483219015924 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 483219015925 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 483219015926 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 483219015927 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219015928 active site 483219015929 phosphorylation site [posttranslational modification] 483219015930 intermolecular recognition site; other site 483219015931 dimerization interface [polypeptide binding]; other site 483219015932 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219015933 Walker A motif; other site 483219015934 ATP binding site [chemical binding]; other site 483219015935 Walker B motif; other site 483219015936 arginine finger; other site 483219015937 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 483219015938 Penicillinase repressor; Region: Pencillinase_R; pfam03965 483219015939 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 483219015940 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 483219015941 Response regulator receiver domain; Region: Response_reg; pfam00072 483219015942 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219015943 active site 483219015944 phosphorylation site [posttranslational modification] 483219015945 intermolecular recognition site; other site 483219015946 dimerization interface [polypeptide binding]; other site 483219015947 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219015948 dimer interface [polypeptide binding]; other site 483219015949 phosphorylation site [posttranslational modification] 483219015950 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219015951 ATP binding site [chemical binding]; other site 483219015952 Mg2+ binding site [ion binding]; other site 483219015953 G-X-G motif; other site 483219015954 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219015955 Response regulator receiver domain; Region: Response_reg; pfam00072 483219015956 active site 483219015957 phosphorylation site [posttranslational modification] 483219015958 intermolecular recognition site; other site 483219015959 dimerization interface [polypeptide binding]; other site 483219015960 Response regulator receiver domain; Region: Response_reg; pfam00072 483219015961 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219015962 active site 483219015963 phosphorylation site [posttranslational modification] 483219015964 intermolecular recognition site; other site 483219015965 dimerization interface [polypeptide binding]; other site 483219015966 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 483219015967 heme-binding site [chemical binding]; other site 483219015968 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219015969 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219015970 dimer interface [polypeptide binding]; other site 483219015971 phosphorylation site [posttranslational modification] 483219015972 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219015973 ATP binding site [chemical binding]; other site 483219015974 Mg2+ binding site [ion binding]; other site 483219015975 G-X-G motif; other site 483219015976 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 483219015977 Transcriptional regulator [Transcription]; Region: LysR; COG0583 483219015978 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 483219015979 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 483219015980 putative dimerization interface [polypeptide binding]; other site 483219015981 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 483219015982 putative hydrophobic ligand binding site [chemical binding]; other site 483219015983 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 483219015984 active site 483219015985 Fatty acid desaturase; Region: FA_desaturase; pfam00487 483219015986 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 483219015987 PAS fold; Region: PAS_4; pfam08448 483219015988 PAS fold; Region: PAS_3; pfam08447 483219015989 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 483219015990 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219015991 phosphorylation site [posttranslational modification] 483219015992 dimer interface [polypeptide binding]; other site 483219015993 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219015994 ATP binding site [chemical binding]; other site 483219015995 Mg2+ binding site [ion binding]; other site 483219015996 G-X-G motif; other site 483219015997 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 483219015998 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219015999 active site 483219016000 phosphorylation site [posttranslational modification] 483219016001 intermolecular recognition site; other site 483219016002 dimerization interface [polypeptide binding]; other site 483219016003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219016004 Walker A motif; other site 483219016005 ATP binding site [chemical binding]; other site 483219016006 Walker B motif; other site 483219016007 arginine finger; other site 483219016008 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 483219016009 Response regulator receiver domain; Region: Response_reg; pfam00072 483219016010 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219016011 active site 483219016012 phosphorylation site [posttranslational modification] 483219016013 intermolecular recognition site; other site 483219016014 dimerization interface [polypeptide binding]; other site 483219016015 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 483219016016 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 483219016017 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 483219016018 ligand binding site [chemical binding]; other site 483219016019 FecR protein; Region: FecR; pfam04773 483219016020 CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080 483219016021 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 483219016022 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219016023 active site 483219016024 phosphorylation site [posttranslational modification] 483219016025 intermolecular recognition site; other site 483219016026 dimerization interface [polypeptide binding]; other site 483219016027 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 483219016028 GAF domain; Region: GAF; pfam01590 483219016029 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 483219016030 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 483219016031 metal binding site [ion binding]; metal-binding site 483219016032 active site 483219016033 I-site; other site 483219016034 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 483219016035 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 483219016036 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219016037 active site 483219016038 phosphorylation site [posttranslational modification] 483219016039 intermolecular recognition site; other site 483219016040 dimerization interface [polypeptide binding]; other site 483219016041 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219016042 Walker A motif; other site 483219016043 ATP binding site [chemical binding]; other site 483219016044 Walker B motif; other site 483219016045 arginine finger; other site 483219016046 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 483219016047 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 483219016048 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219016049 dimer interface [polypeptide binding]; other site 483219016050 phosphorylation site [posttranslational modification] 483219016051 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219016052 ATP binding site [chemical binding]; other site 483219016053 Mg2+ binding site [ion binding]; other site 483219016054 G-X-G motif; other site 483219016055 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 483219016056 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 483219016057 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 483219016058 Coenzyme A transferase; Region: CoA_trans; cl17247 483219016059 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 483219016060 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 483219016061 NAD(P) binding site [chemical binding]; other site 483219016062 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 483219016063 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 483219016064 dimer interface [polypeptide binding]; other site 483219016065 active site 483219016066 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 483219016067 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 483219016068 putative dimer interface [polypeptide binding]; other site 483219016069 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 483219016070 SnoaL-like domain; Region: SnoaL_3; pfam13474 483219016071 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 483219016072 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 483219016073 Soluble P-type ATPase [General function prediction only]; Region: COG4087 483219016074 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 483219016075 ABC-type siderophore export system, fused ATPase and permease components [Secondary metabolites biosynthesis, transport, and catabolism / Inorganic ion transport and metabolism]; Region: PvdE; COG4615 483219016076 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 483219016077 Walker A/P-loop; other site 483219016078 ATP binding site [chemical binding]; other site 483219016079 Q-loop/lid; other site 483219016080 ABC transporter signature motif; other site 483219016081 Walker B; other site 483219016082 D-loop; other site 483219016083 H-loop/switch region; other site 483219016084 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 483219016085 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 483219016086 active site 483219016087 NTP binding site [chemical binding]; other site 483219016088 metal binding triad [ion binding]; metal-binding site 483219016089 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 483219016090 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 483219016091 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 483219016092 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 483219016093 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 483219016094 active site 483219016095 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 483219016096 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 483219016097 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 483219016098 KR domain; Region: KR; pfam08659 483219016099 putative NADP binding site [chemical binding]; other site 483219016100 active site 483219016101 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 483219016102 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 483219016103 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 483219016104 DTAP/Switch II; other site 483219016105 Patatin-like phospholipase; Region: Pat17_PNPLA8_PNPLA9_like1; cd07213 483219016106 nucleophile elbow; other site 483219016107 Condensation domain; Region: Condensation; pfam00668 483219016108 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219016109 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219016110 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 483219016111 acyl-activating enzyme (AAE) consensus motif; other site 483219016112 AMP binding site [chemical binding]; other site 483219016113 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219016114 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 483219016115 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 483219016116 active site 483219016117 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 483219016118 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 483219016119 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 483219016120 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 483219016121 putative NADP binding site [chemical binding]; other site 483219016122 active site 483219016123 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 483219016124 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 483219016125 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 483219016126 active site 483219016127 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 483219016128 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 483219016129 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 483219016130 KR domain; Region: KR; pfam08659 483219016131 putative NADP binding site [chemical binding]; other site 483219016132 active site 483219016133 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 483219016134 Condensation domain; Region: Condensation; pfam00668 483219016135 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219016136 Nonribosomal peptide synthase; Region: NRPS; pfam08415 483219016137 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 483219016138 acyl-activating enzyme (AAE) consensus motif; other site 483219016139 AMP binding site [chemical binding]; other site 483219016140 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219016141 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 483219016142 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 483219016143 active site 483219016144 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 483219016145 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 483219016146 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 483219016147 putative NADP binding site [chemical binding]; other site 483219016148 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 483219016149 active site 483219016150 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 483219016151 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 483219016152 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 483219016153 active site 483219016154 Acyl transferase domain; Region: Acyl_transf_1; cl08282 483219016155 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 483219016156 putative NADP binding site [chemical binding]; other site 483219016157 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 483219016158 active site 483219016159 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 483219016160 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 483219016161 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 483219016162 active site 483219016163 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 483219016164 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 483219016165 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 483219016166 Uncharacterized conserved protein [Function unknown]; Region: COG3379 483219016167 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 483219016168 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 483219016169 active site 483219016170 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 483219016171 AMP-binding enzyme; Region: AMP-binding; pfam00501 483219016172 acyl-activating enzyme (AAE) consensus motif; other site 483219016173 AMP binding site [chemical binding]; other site 483219016174 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 483219016175 translocation protein TolB; Provisional; Region: tolB; PRK01742 483219016176 Predicted membrane protein [Function unknown]; Region: COG2323 483219016177 oxidoreductase; Provisional; Region: PRK06128 483219016178 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 483219016179 NAD(P) binding site [chemical binding]; other site 483219016180 active site 483219016181 Mechanosensitive ion channel; Region: MS_channel; pfam00924 483219016182 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 483219016183 thiamine pyrophosphate protein; Provisional; Region: PRK08273 483219016184 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 483219016185 PYR/PP interface [polypeptide binding]; other site 483219016186 dimer interface [polypeptide binding]; other site 483219016187 tetramer interface [polypeptide binding]; other site 483219016188 TPP binding site [chemical binding]; other site 483219016189 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 483219016190 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 483219016191 TPP-binding site [chemical binding]; other site 483219016192 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 483219016193 FAD binding domain; Region: FAD_binding_4; pfam01565 483219016194 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 483219016195 Cysteine-rich domain; Region: CCG; pfam02754 483219016196 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 3. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_3; cd03328 483219016197 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 483219016198 putative active site pocket [active] 483219016199 putative metal binding site [ion binding]; other site 483219016200 Predicted membrane protein [Function unknown]; Region: COG2323 483219016201 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 483219016202 Protein of unknown function (DUF2381); Region: DUF2381; pfam09544 483219016203 glutamate dehydrogenase; Region: PLN02477 483219016204 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 483219016205 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 483219016206 NAD(P) binding site [chemical binding]; other site 483219016207 PilZ domain; Region: PilZ; pfam07238 483219016208 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 483219016209 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 483219016210 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 483219016211 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 483219016212 protein binding site [polypeptide binding]; other site 483219016213 GrpE; Region: GrpE; pfam01025 483219016214 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 483219016215 dimer interface [polypeptide binding]; other site 483219016216 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 483219016217 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 483219016218 FtsH Extracellular; Region: FtsH_ext; pfam06480 483219016219 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 483219016220 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219016221 Walker A motif; other site 483219016222 ATP binding site [chemical binding]; other site 483219016223 Walker B motif; other site 483219016224 arginine finger; other site 483219016225 Peptidase family M41; Region: Peptidase_M41; pfam01434 483219016226 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 483219016227 active site 483219016228 8-oxo-dGMP binding site [chemical binding]; other site 483219016229 nudix motif; other site 483219016230 metal binding site [ion binding]; metal-binding site 483219016231 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 483219016232 non-specific DNA binding site [nucleotide binding]; other site 483219016233 salt bridge; other site 483219016234 sequence-specific DNA binding site [nucleotide binding]; other site 483219016235 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219016236 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219016237 active site 483219016238 ATP binding site [chemical binding]; other site 483219016239 substrate binding site [chemical binding]; other site 483219016240 activation loop (A-loop); other site 483219016241 AAA ATPase domain; Region: AAA_16; pfam13191 483219016242 Tetratricopeptide repeat; Region: TPR_12; pfam13424 483219016243 Protein kinase domain; Region: Pkinase; pfam00069 483219016244 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219016245 active site 483219016246 ATP binding site [chemical binding]; other site 483219016247 substrate binding site [chemical binding]; other site 483219016248 activation loop (A-loop); other site 483219016249 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 483219016250 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 483219016251 phosphopeptide binding site; other site 483219016252 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 483219016253 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219016254 Walker A motif; other site 483219016255 ATP binding site [chemical binding]; other site 483219016256 Walker B motif; other site 483219016257 arginine finger; other site 483219016258 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 483219016259 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 483219016260 putative molybdopterin cofactor binding site [chemical binding]; other site 483219016261 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 483219016262 putative molybdopterin cofactor binding site; other site 483219016263 BON domain; Region: BON; pfam04972 483219016264 urocanate hydratase; Provisional; Region: PRK05414 483219016265 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 483219016266 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 483219016267 imidazolonepropionase; Region: hutI; TIGR01224 483219016268 active site 483219016269 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 483219016270 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 483219016271 putative dimer interface [polypeptide binding]; other site 483219016272 putative active site [active] 483219016273 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 483219016274 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 483219016275 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 483219016276 putative substrate binding site [chemical binding]; other site 483219016277 putative ATP binding site [chemical binding]; other site 483219016278 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 483219016279 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 483219016280 active site 483219016281 hydrophilic channel; other site 483219016282 dimerization interface [polypeptide binding]; other site 483219016283 catalytic residues [active] 483219016284 active site lid [active] 483219016285 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 483219016286 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 483219016287 active site 483219016288 substrate binding site [chemical binding]; other site 483219016289 metal binding site [ion binding]; metal-binding site 483219016290 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 483219016291 dihydropteroate synthase; Region: DHPS; TIGR01496 483219016292 substrate binding pocket [chemical binding]; other site 483219016293 dimer interface [polypeptide binding]; other site 483219016294 inhibitor binding site; inhibition site 483219016295 OsmC-like protein; Region: OsmC; pfam02566 483219016296 Uncharacterized conserved protein [Function unknown]; Region: COG2353 483219016297 LysR family transcriptional regulator; Provisional; Region: PRK14997 483219016298 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 483219016299 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 483219016300 putative effector binding pocket; other site 483219016301 dimerization interface [polypeptide binding]; other site 483219016302 Pirin-related protein [General function prediction only]; Region: COG1741 483219016303 Pirin; Region: Pirin; pfam02678 483219016304 Pirin-related protein [General function prediction only]; Region: COG1741 483219016305 Pirin; Region: Pirin; pfam02678 483219016306 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 483219016307 FtsH Extracellular; Region: FtsH_ext; pfam06480 483219016308 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 483219016309 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 483219016310 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219016311 Walker A motif; other site 483219016312 ATP binding site [chemical binding]; other site 483219016313 Walker B motif; other site 483219016314 arginine finger; other site 483219016315 Peptidase family M41; Region: Peptidase_M41; pfam01434 483219016316 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 483219016317 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 483219016318 Ligand Binding Site [chemical binding]; other site 483219016319 TilS substrate C-terminal domain; Region: TilS_C; smart00977 483219016320 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 483219016321 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 483219016322 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 483219016323 N-terminal plug; other site 483219016324 ligand-binding site [chemical binding]; other site 483219016325 Protein of unknown function, DUF399; Region: DUF399; cl01139 483219016326 High-affinity K+ transport system, ATPase chain B [Inorganic ion transport and metabolism]; Region: KdpB; COG2216 483219016327 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219016328 S-adenosylmethionine binding site [chemical binding]; other site 483219016329 DNA methylase; Region: N6_N4_Mtase; cl17433 483219016330 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 483219016331 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 483219016332 NAD(P) binding site [chemical binding]; other site 483219016333 active site 483219016334 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 483219016335 active site 483219016336 ATP binding site [chemical binding]; other site 483219016337 substrate binding site [chemical binding]; other site 483219016338 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 483219016339 substrate binding site [chemical binding]; other site 483219016340 activation loop (A-loop); other site 483219016341 activation loop (A-loop); other site 483219016342 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 483219016343 non-specific DNA binding site [nucleotide binding]; other site 483219016344 salt bridge; other site 483219016345 sequence-specific DNA binding site [nucleotide binding]; other site 483219016346 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219016347 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219016348 active site 483219016349 ATP binding site [chemical binding]; other site 483219016350 substrate binding site [chemical binding]; other site 483219016351 activation loop (A-loop); other site 483219016352 Myxococcus xanthus paralogous family TIGR02268; Region: TIGR02268 483219016353 Protein of unknown function (DUF2379); Region: DUF2379; cl15283 483219016354 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 483219016355 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 483219016356 active site 2 [active] 483219016357 active site 1 [active] 483219016358 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 483219016359 B12 binding domain (B12-BD). This domain binds different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide, it is found in several enzymes, such as glutamate mutase, methionine synthase...; Region: B12-binding; cd02067 483219016360 B12 binding site [chemical binding]; other site 483219016361 cobalt ligand [ion binding]; other site 483219016362 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 483219016363 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 483219016364 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 483219016365 tetramer interface [polypeptide binding]; other site 483219016366 heme binding pocket [chemical binding]; other site 483219016367 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 483219016368 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 483219016369 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 483219016370 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 483219016371 NAD(P) binding site [chemical binding]; other site 483219016372 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 483219016373 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 483219016374 Fe-S cluster binding site [ion binding]; other site 483219016375 active site 483219016376 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 483219016377 CoenzymeA binding site [chemical binding]; other site 483219016378 subunit interaction site [polypeptide binding]; other site 483219016379 PHB binding site; other site 483219016380 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 483219016381 Flavoprotein; Region: Flavoprotein; pfam02441 483219016382 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 483219016383 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 483219016384 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 483219016385 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 483219016386 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 483219016387 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 483219016388 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 483219016389 Protein phosphatase 2C; Region: PP2C; pfam00481 483219016390 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 483219016391 active site 483219016392 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 483219016393 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 483219016394 ligand binding site [chemical binding]; other site 483219016395 flexible hinge region; other site 483219016396 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 483219016397 phosphopeptide binding site; other site 483219016398 Amidinotransferase; Region: Amidinotransf; cl12043 483219016399 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 483219016400 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 483219016401 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 483219016402 active site 483219016403 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 483219016404 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 483219016405 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219016406 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 483219016407 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 483219016408 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 483219016409 catalytic residue [active] 483219016410 Condensation domain; Region: Condensation; pfam00668 483219016411 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219016412 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219016413 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 483219016414 acyl-activating enzyme (AAE) consensus motif; other site 483219016415 AMP binding site [chemical binding]; other site 483219016416 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219016417 Condensation domain; Region: Condensation; pfam00668 483219016418 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219016419 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219016420 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 483219016421 acyl-activating enzyme (AAE) consensus motif; other site 483219016422 AMP binding site [chemical binding]; other site 483219016423 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219016424 Condensation domain; Region: Condensation; pfam00668 483219016425 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219016426 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219016427 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 483219016428 acyl-activating enzyme (AAE) consensus motif; other site 483219016429 AMP binding site [chemical binding]; other site 483219016430 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219016431 peptide synthase; Provisional; Region: PRK12467 483219016432 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 483219016433 acyl-activating enzyme (AAE) consensus motif; other site 483219016434 AMP binding site [chemical binding]; other site 483219016435 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219016436 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219016437 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 483219016438 acyl-activating enzyme (AAE) consensus motif; other site 483219016439 AMP binding site [chemical binding]; other site 483219016440 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219016441 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 483219016442 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 483219016443 acyl-activating enzyme (AAE) consensus motif; other site 483219016444 AMP binding site [chemical binding]; other site 483219016445 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219016446 Condensation domain; Region: Condensation; pfam00668 483219016447 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219016448 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219016449 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 483219016450 acyl-activating enzyme (AAE) consensus motif; other site 483219016451 AMP binding site [chemical binding]; other site 483219016452 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219016453 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 483219016454 H+ Antiporter protein; Region: 2A0121; TIGR00900 483219016455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483219016456 acyl-CoA synthetase; Validated; Region: PRK05850 483219016457 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 483219016458 acyl-activating enzyme (AAE) consensus motif; other site 483219016459 active site 483219016460 transcriptional regulator; Provisional; Region: PRK10632 483219016461 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 483219016462 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 483219016463 putative effector binding pocket; other site 483219016464 dimerization interface [polypeptide binding]; other site 483219016465 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 483219016466 NAD(P) binding site [chemical binding]; other site 483219016467 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 483219016468 active site 483219016469 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 483219016470 Low molecular weight phosphatase family; Region: LMWPc; cd00115 483219016471 active site 483219016472 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 483219016473 arsenical-resistance protein; Region: acr3; TIGR00832 483219016474 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 483219016475 dimerization interface [polypeptide binding]; other site 483219016476 putative DNA binding site [nucleotide binding]; other site 483219016477 putative Zn2+ binding site [ion binding]; other site 483219016478 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 483219016479 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 483219016480 Chromate transporter; Region: Chromate_transp; pfam02417 483219016481 Predicted membrane protein [Function unknown]; Region: COG2259 483219016482 short chain dehydrogenase; Provisional; Region: PRK07109 483219016483 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 483219016484 putative NAD(P) binding site [chemical binding]; other site 483219016485 active site 483219016486 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 483219016487 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 483219016488 Vitamin K epoxide reductase family in bacteria; Region: VKOR_2; cd12919 483219016489 putative active site [active] 483219016490 redox center [active] 483219016491 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 483219016492 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 483219016493 active site 483219016494 ATP binding site [chemical binding]; other site 483219016495 substrate binding site [chemical binding]; other site 483219016496 Outer membrane efflux protein; Region: OEP; pfam02321 483219016497 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 483219016498 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219016499 Walker A/P-loop; other site 483219016500 ATP binding site [chemical binding]; other site 483219016501 Q-loop/lid; other site 483219016502 ABC transporter signature motif; other site 483219016503 Walker B; other site 483219016504 D-loop; other site 483219016505 H-loop/switch region; other site 483219016506 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 483219016507 putative active site [active] 483219016508 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 483219016509 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219016510 Walker A/P-loop; other site 483219016511 ATP binding site [chemical binding]; other site 483219016512 Q-loop/lid; other site 483219016513 ABC transporter signature motif; other site 483219016514 Walker B; other site 483219016515 D-loop; other site 483219016516 H-loop/switch region; other site 483219016517 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 483219016518 HlyD family secretion protein; Region: HlyD_3; pfam13437 483219016519 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 483219016520 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 483219016521 active site 483219016522 Predicted membrane protein [Function unknown]; Region: COG2119 483219016523 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 483219016524 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 483219016525 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 483219016526 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 483219016527 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 483219016528 Domain of unknown function (DUF329); Region: DUF329; pfam03884 483219016529 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 483219016530 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 483219016531 NAD(P) binding site [chemical binding]; other site 483219016532 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 483219016533 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 483219016534 agmatinase; Region: agmatinase; TIGR01230 483219016535 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 483219016536 putative active site [active] 483219016537 Mn binding site [ion binding]; other site 483219016538 Response regulator receiver domain; Region: Response_reg; pfam00072 483219016539 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219016540 active site 483219016541 phosphorylation site [posttranslational modification] 483219016542 intermolecular recognition site; other site 483219016543 dimerization interface [polypeptide binding]; other site 483219016544 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219016545 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219016546 ATP binding site [chemical binding]; other site 483219016547 Mg2+ binding site [ion binding]; other site 483219016548 G-X-G motif; other site 483219016549 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 483219016550 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 483219016551 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 483219016552 protein binding site [polypeptide binding]; other site 483219016553 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 483219016554 protein binding site [polypeptide binding]; other site 483219016555 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 483219016556 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 483219016557 active site 483219016558 ATP binding site [chemical binding]; other site 483219016559 substrate binding site [chemical binding]; other site 483219016560 activation loop (A-loop); other site 483219016561 PEGA domain; Region: PEGA; pfam08308 483219016562 PEGA domain; Region: PEGA; pfam08308 483219016563 Uncharacterized conserved protein [Function unknown]; Region: COG3268 483219016564 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 483219016565 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 483219016566 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 483219016567 active site 483219016568 Response regulator receiver domain; Region: Response_reg; pfam00072 483219016569 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219016570 active site 483219016571 phosphorylation site [posttranslational modification] 483219016572 intermolecular recognition site; other site 483219016573 dimerization interface [polypeptide binding]; other site 483219016574 Herpesvirus transcription activation factor (transactivator); Region: Herpes_TAF50; pfam03326 483219016575 cell surface protein SprA; Region: surface_SprA; TIGR04189 483219016576 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 483219016577 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 483219016578 FecR protein; Region: FecR; pfam04773 483219016579 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219016580 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219016581 dimerization interface [polypeptide binding]; other site 483219016582 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219016583 phosphorylation site [posttranslational modification] 483219016584 dimer interface [polypeptide binding]; other site 483219016585 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219016586 ATP binding site [chemical binding]; other site 483219016587 Mg2+ binding site [ion binding]; other site 483219016588 G-X-G motif; other site 483219016589 Response regulator receiver domain; Region: Response_reg; pfam00072 483219016590 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219016591 active site 483219016592 phosphorylation site [posttranslational modification] 483219016593 intermolecular recognition site; other site 483219016594 dimerization interface [polypeptide binding]; other site 483219016595 GAF domain; Region: GAF_3; pfam13492 483219016596 GAF domain; Region: GAF_2; pfam13185 483219016597 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 483219016598 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219016599 putative active site [active] 483219016600 heme pocket [chemical binding]; other site 483219016601 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219016602 dimer interface [polypeptide binding]; other site 483219016603 phosphorylation site [posttranslational modification] 483219016604 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219016605 ATP binding site [chemical binding]; other site 483219016606 Mg2+ binding site [ion binding]; other site 483219016607 G-X-G motif; other site 483219016608 Response regulator receiver domain; Region: Response_reg; pfam00072 483219016609 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219016610 active site 483219016611 phosphorylation site [posttranslational modification] 483219016612 intermolecular recognition site; other site 483219016613 dimerization interface [polypeptide binding]; other site 483219016614 Response regulator receiver domain; Region: Response_reg; pfam00072 483219016615 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219016616 active site 483219016617 phosphorylation site [posttranslational modification] 483219016618 intermolecular recognition site; other site 483219016619 dimerization interface [polypeptide binding]; other site 483219016620 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 483219016621 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 483219016622 metal binding site [ion binding]; metal-binding site 483219016623 active site 483219016624 I-site; other site 483219016625 LexA repressor; Validated; Region: PRK00215 483219016626 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 483219016627 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 483219016628 Catalytic site [active] 483219016629 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219016630 TPR motif; other site 483219016631 binding surface 483219016632 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219016633 binding surface 483219016634 TPR motif; other site 483219016635 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 483219016636 TPR motif; other site 483219016637 binding surface 483219016638 Predicted integral membrane protein [Function unknown]; Region: COG5616 483219016639 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 483219016640 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 483219016641 Peptidase family M23; Region: Peptidase_M23; pfam01551 483219016642 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 483219016643 enolase; Provisional; Region: eno; PRK00077 483219016644 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 483219016645 dimer interface [polypeptide binding]; other site 483219016646 metal binding site [ion binding]; metal-binding site 483219016647 substrate binding pocket [chemical binding]; other site 483219016648 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 483219016649 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 483219016650 hydrophobic ligand binding site; other site 483219016651 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 483219016652 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 483219016653 putative active site [active] 483219016654 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 483219016655 active site 483219016656 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 483219016657 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 483219016658 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 483219016659 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 483219016660 dimerization interface [polypeptide binding]; other site 483219016661 active site 483219016662 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 483219016663 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 483219016664 HIGH motif; other site 483219016665 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 483219016666 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 483219016667 active site 483219016668 KMSKS motif; other site 483219016669 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 483219016670 tRNA binding surface [nucleotide binding]; other site 483219016671 anticodon binding site; other site 483219016672 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 483219016673 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 483219016674 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219016675 active site 483219016676 phosphorylation site [posttranslational modification] 483219016677 intermolecular recognition site; other site 483219016678 dimerization interface [polypeptide binding]; other site 483219016679 Response regulator receiver domain; Region: Response_reg; pfam00072 483219016680 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219016681 active site 483219016682 phosphorylation site [posttranslational modification] 483219016683 intermolecular recognition site; other site 483219016684 dimerization interface [polypeptide binding]; other site 483219016685 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 483219016686 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 483219016687 metal binding site [ion binding]; metal-binding site 483219016688 active site 483219016689 I-site; other site 483219016690 Uncharacterized conserved protein [Function unknown]; Region: COG3461 483219016691 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219016692 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219016693 phosphorylation site [posttranslational modification] 483219016694 dimer interface [polypeptide binding]; other site 483219016695 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219016696 ATP binding site [chemical binding]; other site 483219016697 Mg2+ binding site [ion binding]; other site 483219016698 G-X-G motif; other site 483219016699 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 483219016700 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219016701 active site 483219016702 phosphorylation site [posttranslational modification] 483219016703 intermolecular recognition site; other site 483219016704 dimerization interface [polypeptide binding]; other site 483219016705 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 483219016706 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 483219016707 ring oligomerisation interface [polypeptide binding]; other site 483219016708 ATP/Mg binding site [chemical binding]; other site 483219016709 stacking interactions; other site 483219016710 hinge regions; other site 483219016711 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219016712 Response regulator receiver domain; Region: Response_reg; pfam00072 483219016713 active site 483219016714 phosphorylation site [posttranslational modification] 483219016715 intermolecular recognition site; other site 483219016716 dimerization interface [polypeptide binding]; other site 483219016717 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219016718 TPR motif; other site 483219016719 binding surface 483219016720 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219016721 TPR motif; other site 483219016722 binding surface 483219016723 TPR repeat; Region: TPR_11; pfam13414 483219016724 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 483219016725 atypical (a) SDRs, subgroup 3; Region: SDR_a3; cd05229 483219016726 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 483219016727 putative NAD(P) binding site [chemical binding]; other site 483219016728 putative active site [active] 483219016729 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 483219016730 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 483219016731 WHG domain; Region: WHG; pfam13305 483219016732 Divergent AAA domain; Region: AAA_4; pfam04326 483219016733 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 483219016734 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 483219016735 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 483219016736 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 483219016737 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 483219016738 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 483219016739 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 483219016740 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 483219016741 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 483219016742 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 483219016743 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 483219016744 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 483219016745 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 483219016746 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 483219016747 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 483219016748 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 483219016749 phage tail protein domain; Region: tail_TIGR02242 483219016750 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219016751 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 483219016752 Walker A motif; other site 483219016753 ATP binding site [chemical binding]; other site 483219016754 Walker B motif; other site 483219016755 arginine finger; other site 483219016756 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 483219016757 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 483219016758 Sulfatase; Region: Sulfatase; pfam00884 483219016759 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 483219016760 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 483219016761 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 483219016762 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 483219016763 acyl-activating enzyme (AAE) consensus motif; other site 483219016764 active site 483219016765 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 483219016766 Condensation domain; Region: Condensation; pfam00668 483219016767 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 483219016768 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 483219016769 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 483219016770 acyl-activating enzyme (AAE) consensus motif; other site 483219016771 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 483219016772 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 483219016773 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 483219016774 AMP binding site [chemical binding]; other site 483219016775 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 483219016776 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483219016777 putative substrate translocation pore; other site 483219016778 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 483219016779 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 483219016780 putative sugar binding sites [chemical binding]; other site 483219016781 Q-X-W motif; other site 483219016782 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 483219016783 putative sugar binding site [chemical binding]; other site 483219016784 catalytic residues [active] 483219016785 RNA polymerase sigma factor; Provisional; Region: PRK12519 483219016786 Domain of unknown function (DUF955); Region: DUF955; pfam06114 483219016787 HerA helicase [Replication, recombination, and repair]; Region: COG0433 483219016788 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 483219016789 putative catalytic site [active] 483219016790 putative metal binding site [ion binding]; other site 483219016791 putative phosphate binding site [ion binding]; other site 483219016792 YceI-like domain; Region: YceI; smart00867 483219016793 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 483219016794 B12 binding site [chemical binding]; other site 483219016795 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 483219016796 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 483219016797 FeS/SAM binding site; other site 483219016798 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 483219016799 cyclase homology domain; Region: CHD; cd07302 483219016800 nucleotidyl binding site; other site 483219016801 metal binding site [ion binding]; metal-binding site 483219016802 dimer interface [polypeptide binding]; other site 483219016803 cyclase homology domain; Region: CHD; cd07302 483219016804 dimer interface [polypeptide binding]; other site 483219016805 nucleotidyl binding site; other site 483219016806 metal binding site [ion binding]; metal-binding site 483219016807 AAA ATPase domain; Region: AAA_16; pfam13191 483219016808 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219016809 TPR motif; other site 483219016810 Tetratricopeptide repeat; Region: TPR_12; pfam13424 483219016811 binding surface 483219016812 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 483219016813 Reverse gyrase [DNA replication, recombination, and repair]; Region: COG1110 483219016814 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 483219016815 dimerization interface [polypeptide binding]; other site 483219016816 putative DNA binding site [nucleotide binding]; other site 483219016817 putative Zn2+ binding site [ion binding]; other site 483219016818 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894 483219016819 putative hydrophobic ligand binding site [chemical binding]; other site 483219016820 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 483219016821 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 483219016822 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 483219016823 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 483219016824 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219016825 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219016826 active site 483219016827 ATP binding site [chemical binding]; other site 483219016828 substrate binding site [chemical binding]; other site 483219016829 activation loop (A-loop); other site 483219016830 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 483219016831 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 483219016832 N-terminal plug; other site 483219016833 ligand-binding site [chemical binding]; other site 483219016834 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 483219016835 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 483219016836 binding surface 483219016837 TPR motif; other site 483219016838 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219016839 TPR motif; other site 483219016840 binding surface 483219016841 TPR repeat; Region: TPR_11; pfam13414 483219016842 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 483219016843 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 483219016844 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 483219016845 Peptidase family M50; Region: Peptidase_M50; pfam02163 483219016846 active site 483219016847 putative substrate binding region [chemical binding]; other site 483219016848 tetratricopeptide repeat protein; Provisional; Region: PRK11788 483219016849 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 483219016850 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 483219016851 tetramer interface [polypeptide binding]; other site 483219016852 TPP-binding site [chemical binding]; other site 483219016853 heterodimer interface [polypeptide binding]; other site 483219016854 phosphorylation loop region [posttranslational modification] 483219016855 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 483219016856 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 483219016857 PYR/PP interface [polypeptide binding]; other site 483219016858 dimer interface [polypeptide binding]; other site 483219016859 TPP binding site [chemical binding]; other site 483219016860 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 483219016861 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 483219016862 Coenzyme A binding pocket [chemical binding]; other site 483219016863 Myxococcus xanthus paralogous domain TIGR02266; Region: gmx_TIGR02266 483219016864 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 483219016865 active site 483219016866 catalytic triad [active] 483219016867 oxyanion hole [active] 483219016868 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 483219016869 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 483219016870 DEAD-like helicases superfamily; Region: DEXDc; smart00487 483219016871 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 483219016872 ATP binding site [chemical binding]; other site 483219016873 putative Mg++ binding site [ion binding]; other site 483219016874 helicase superfamily c-terminal domain; Region: HELICc; smart00490 483219016875 nucleotide binding region [chemical binding]; other site 483219016876 ATP-binding site [chemical binding]; other site 483219016877 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 483219016878 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 483219016879 Sulfate transporter family; Region: Sulfate_transp; pfam00916 483219016880 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 483219016881 anti sigma factor interaction site; other site 483219016882 regulatory phosphorylation site [posttranslational modification]; other site 483219016883 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219016884 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219016885 dimerization interface [polypeptide binding]; other site 483219016886 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219016887 dimer interface [polypeptide binding]; other site 483219016888 phosphorylation site [posttranslational modification] 483219016889 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219016890 ATP binding site [chemical binding]; other site 483219016891 Mg2+ binding site [ion binding]; other site 483219016892 G-X-G motif; other site 483219016893 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 483219016894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219016895 active site 483219016896 phosphorylation site [posttranslational modification] 483219016897 intermolecular recognition site; other site 483219016898 dimerization interface [polypeptide binding]; other site 483219016899 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219016900 Walker A motif; other site 483219016901 ATP binding site [chemical binding]; other site 483219016902 Walker B motif; other site 483219016903 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 483219016904 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 483219016905 CoA binding domain; Region: CoA_binding_2; pfam13380 483219016906 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 483219016907 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 483219016908 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 483219016909 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 483219016910 Myxococcales-restricted protein, TIGR02265 family; Region: Mxa_TIGR02265 483219016911 Protein of unknown function (DUF3014); Region: DUF3014; pfam11219 483219016912 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219016913 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 483219016914 active site 483219016915 phosphorylation site [posttranslational modification] 483219016916 intermolecular recognition site; other site 483219016917 dimerization interface [polypeptide binding]; other site 483219016918 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219016919 Walker A motif; other site 483219016920 ATP binding site [chemical binding]; other site 483219016921 Walker B motif; other site 483219016922 arginine finger; other site 483219016923 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 483219016924 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 483219016925 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 483219016926 ligand binding site [chemical binding]; other site 483219016927 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 483219016928 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 483219016929 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 483219016930 catalytic site [active] 483219016931 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 483219016932 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 483219016933 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 483219016934 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 483219016935 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219016936 Walker A/P-loop; other site 483219016937 ATP binding site [chemical binding]; other site 483219016938 Q-loop/lid; other site 483219016939 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 483219016940 ABC transporter signature motif; other site 483219016941 Walker B; other site 483219016942 D-loop; other site 483219016943 ABC transporter; Region: ABC_tran_2; pfam12848 483219016944 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 483219016945 Fn3 associated; Region: Fn3_assoc; pfam13287 483219016946 Fn3 associated; Region: Fn3_assoc; pfam13287 483219016947 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 483219016948 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 483219016949 Fn3 associated; Region: Fn3_assoc; pfam13287 483219016950 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 483219016951 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 483219016952 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 483219016953 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 483219016954 Fn3 associated; Region: Fn3_assoc; pfam13287 483219016955 Fn3 associated; Region: Fn3_assoc; pfam13287 483219016956 Fn3 associated; Region: Fn3_assoc; pfam13287 483219016957 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 483219016958 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 483219016959 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 483219016960 PEGA domain; Region: PEGA; pfam08308 483219016961 PEGA domain; Region: PEGA; pfam08308 483219016962 TPR repeat; Region: TPR_11; pfam13414 483219016963 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 483219016964 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 483219016965 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219016966 active site 483219016967 ATP binding site [chemical binding]; other site 483219016968 substrate binding site [chemical binding]; other site 483219016969 activation loop (A-loop); other site 483219016970 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 483219016971 putative hydrophobic ligand binding site [chemical binding]; other site 483219016972 putative transporter; Provisional; Region: PRK10504 483219016973 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483219016974 putative substrate translocation pore; other site 483219016975 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 483219016976 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 483219016977 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 483219016978 substrate binding site; other site 483219016979 tetramer interface; other site 483219016980 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 483219016981 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 483219016982 NADP binding site [chemical binding]; other site 483219016983 active site 483219016984 putative substrate binding site [chemical binding]; other site 483219016985 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 483219016986 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 483219016987 NAD binding site [chemical binding]; other site 483219016988 substrate binding site [chemical binding]; other site 483219016989 homodimer interface [polypeptide binding]; other site 483219016990 active site 483219016991 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 483219016992 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 483219016993 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 483219016994 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 483219016995 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 483219016996 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 483219016997 active site 483219016998 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 483219016999 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 483219017000 Ligand binding site; other site 483219017001 Putative Catalytic site; other site 483219017002 DXD motif; other site 483219017003 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 483219017004 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 483219017005 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 483219017006 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 483219017007 active site 483219017008 Methyltransferase domain; Region: Methyltransf_23; pfam13489 483219017009 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219017010 S-adenosylmethionine binding site [chemical binding]; other site 483219017011 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 483219017012 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 483219017013 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 483219017014 Probable Catalytic site; other site 483219017015 metal-binding site 483219017016 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 483219017017 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 483219017018 Probable Catalytic site; other site 483219017019 metal-binding site 483219017020 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 483219017021 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 483219017022 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 483219017023 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 483219017024 Walker A/P-loop; other site 483219017025 ATP binding site [chemical binding]; other site 483219017026 Q-loop/lid; other site 483219017027 ABC transporter signature motif; other site 483219017028 Walker B; other site 483219017029 D-loop; other site 483219017030 H-loop/switch region; other site 483219017031 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 483219017032 putative carbohydrate binding site [chemical binding]; other site 483219017033 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 483219017034 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 483219017035 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 483219017036 TPR repeat; Region: TPR_11; pfam13414 483219017037 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219017038 binding surface 483219017039 TPR motif; other site 483219017040 TPR repeat; Region: TPR_11; pfam13414 483219017041 TPR repeat; Region: TPR_11; pfam13414 483219017042 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 483219017043 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 483219017044 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 483219017045 N-acetyl-D-glucosamine binding site [chemical binding]; other site 483219017046 catalytic residue [active] 483219017047 L-aspartate oxidase; Provisional; Region: PRK09077 483219017048 L-aspartate oxidase; Provisional; Region: PRK06175 483219017049 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 483219017050 Rhomboid family; Region: Rhomboid; pfam01694 483219017051 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 483219017052 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12698 483219017053 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 483219017054 active site 483219017055 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 483219017056 ParB-like nuclease domain; Region: ParBc; pfam02195 483219017057 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 483219017058 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 483219017059 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 483219017060 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 483219017061 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 483219017062 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 483219017063 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 483219017064 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 483219017065 TPR motif; other site 483219017066 binding surface 483219017067 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219017068 Tetratricopeptide repeat; Region: TPR_12; pfam13424 483219017069 binding surface 483219017070 TPR motif; other site 483219017071 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 483219017072 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 483219017073 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219017074 dimer interface [polypeptide binding]; other site 483219017075 phosphorylation site [posttranslational modification] 483219017076 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219017077 ATP binding site [chemical binding]; other site 483219017078 Mg2+ binding site [ion binding]; other site 483219017079 G-X-G motif; other site 483219017080 Response regulator receiver domain; Region: Response_reg; pfam00072 483219017081 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219017082 active site 483219017083 phosphorylation site [posttranslational modification] 483219017084 intermolecular recognition site; other site 483219017085 dimerization interface [polypeptide binding]; other site 483219017086 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 483219017087 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 483219017088 metal binding site [ion binding]; metal-binding site 483219017089 active site 483219017090 I-site; other site 483219017091 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 483219017092 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 483219017093 RNA binding surface [nucleotide binding]; other site 483219017094 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 483219017095 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 483219017096 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 483219017097 TPP-binding site; other site 483219017098 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 483219017099 PYR/PP interface [polypeptide binding]; other site 483219017100 dimer interface [polypeptide binding]; other site 483219017101 TPP binding site [chemical binding]; other site 483219017102 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 483219017103 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 483219017104 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 483219017105 substrate binding pocket [chemical binding]; other site 483219017106 chain length determination region; other site 483219017107 substrate-Mg2+ binding site; other site 483219017108 catalytic residues [active] 483219017109 aspartate-rich region 1; other site 483219017110 active site lid residues [active] 483219017111 aspartate-rich region 2; other site 483219017112 Response regulator receiver domain; Region: Response_reg; pfam00072 483219017113 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219017114 active site 483219017115 phosphorylation site [posttranslational modification] 483219017116 intermolecular recognition site; other site 483219017117 dimerization interface [polypeptide binding]; other site 483219017118 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 483219017119 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 483219017120 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 483219017121 generic binding surface II; other site 483219017122 generic binding surface I; other site 483219017123 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 483219017124 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 483219017125 phosphopeptide binding site; other site 483219017126 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 483219017127 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 483219017128 phosphopeptide binding site; other site 483219017129 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 483219017130 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 483219017131 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 483219017132 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 483219017133 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 483219017134 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 483219017135 TadE-like protein; Region: TadE; pfam07811 483219017136 Putative zinc-finger; Region: zf-HC2; pfam13490 483219017137 RNA polymerase sigma factor; Provisional; Region: PRK12513 483219017138 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 483219017139 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 483219017140 DNA binding residues [nucleotide binding] 483219017141 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 483219017142 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 483219017143 Walker A/P-loop; other site 483219017144 ATP binding site [chemical binding]; other site 483219017145 Q-loop/lid; other site 483219017146 ABC transporter signature motif; other site 483219017147 Walker B; other site 483219017148 D-loop; other site 483219017149 H-loop/switch region; other site 483219017150 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 483219017151 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 483219017152 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 483219017153 Walker A/P-loop; other site 483219017154 ATP binding site [chemical binding]; other site 483219017155 Q-loop/lid; other site 483219017156 ABC transporter signature motif; other site 483219017157 Walker B; other site 483219017158 D-loop; other site 483219017159 H-loop/switch region; other site 483219017160 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 483219017161 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 483219017162 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 483219017163 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125 483219017164 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 483219017165 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 483219017166 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 483219017167 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 483219017168 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 483219017169 active site 483219017170 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 483219017171 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 483219017172 active site 483219017173 catalytic site [active] 483219017174 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 483219017175 active site 483219017176 catalytic site [active] 483219017177 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 483219017178 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 483219017179 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219017180 active site 483219017181 phosphorylation site [posttranslational modification] 483219017182 intermolecular recognition site; other site 483219017183 dimerization interface [polypeptide binding]; other site 483219017184 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 483219017185 Zn2+ binding site [ion binding]; other site 483219017186 Mg2+ binding site [ion binding]; other site 483219017187 HEAT repeats; Region: HEAT_2; pfam13646 483219017188 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 483219017189 active site 483219017190 MoxR-like ATPases [General function prediction only]; Region: COG0714 483219017191 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219017192 Walker A motif; other site 483219017193 ATP binding site [chemical binding]; other site 483219017194 Walker B motif; other site 483219017195 arginine finger; other site 483219017196 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 483219017197 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 483219017198 metal ion-dependent adhesion site (MIDAS); other site 483219017199 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 483219017200 ATP binding site [chemical binding]; other site 483219017201 putative Mg++ binding site [ion binding]; other site 483219017202 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 483219017203 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 483219017204 nucleotide binding region [chemical binding]; other site 483219017205 ATP-binding site [chemical binding]; other site 483219017206 Smr domain; Region: Smr; pfam01713 483219017207 Protein of unknown function DUF72; Region: DUF72; pfam01904 483219017208 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 483219017209 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 483219017210 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 483219017211 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 483219017212 dimer interface [polypeptide binding]; other site 483219017213 anticodon binding site; other site 483219017214 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 483219017215 homodimer interface [polypeptide binding]; other site 483219017216 motif 1; other site 483219017217 active site 483219017218 motif 2; other site 483219017219 GAD domain; Region: GAD; pfam02938 483219017220 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 483219017221 active site 483219017222 motif 3; other site 483219017223 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 483219017224 Zn binding site [ion binding]; other site 483219017225 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 483219017226 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 483219017227 DHH family; Region: DHH; pfam01368 483219017228 DHHA1 domain; Region: DHHA1; pfam02272 483219017229 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 483219017230 protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966 483219017231 Protein export membrane protein; Region: SecD_SecF; pfam02355 483219017232 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 483219017233 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 483219017234 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 483219017235 Preprotein translocase subunit; Region: YajC; pfam02699 483219017236 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 483219017237 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 483219017238 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 483219017239 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 483219017240 Stage II sporulation protein; Region: SpoIID; pfam08486 483219017241 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 483219017242 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 483219017243 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 483219017244 FeS/SAM binding site; other site 483219017245 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 483219017246 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 483219017247 Radical SAM superfamily; Region: Radical_SAM; pfam04055 483219017248 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 483219017249 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219017250 active site 483219017251 ATP binding site [chemical binding]; other site 483219017252 substrate binding site [chemical binding]; other site 483219017253 activation loop (A-loop); other site 483219017254 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 483219017255 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 483219017256 catalytic site [active] 483219017257 G-X2-G-X-G-K; other site 483219017258 hypothetical protein; Provisional; Region: PRK11820 483219017259 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 483219017260 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 483219017261 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 483219017262 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 483219017263 putative active site [active] 483219017264 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 483219017265 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 483219017266 active site 483219017267 nucleotide binding site [chemical binding]; other site 483219017268 HIGH motif; other site 483219017269 KMSKS motif; other site 483219017270 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 483219017271 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 483219017272 substrate binding site [chemical binding]; other site 483219017273 ATP binding site [chemical binding]; other site 483219017274 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 483219017275 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 483219017276 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 483219017277 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 483219017278 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 483219017279 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 483219017280 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 483219017281 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 483219017282 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 483219017283 active site 483219017284 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 483219017285 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 483219017286 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219017287 Walker A/P-loop; other site 483219017288 ATP binding site [chemical binding]; other site 483219017289 Q-loop/lid; other site 483219017290 ABC transporter signature motif; other site 483219017291 Walker B; other site 483219017292 D-loop; other site 483219017293 H-loop/switch region; other site 483219017294 Response regulator receiver domain; Region: Response_reg; pfam00072 483219017295 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219017296 active site 483219017297 phosphorylation site [posttranslational modification] 483219017298 intermolecular recognition site; other site 483219017299 dimerization interface [polypeptide binding]; other site 483219017300 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 483219017301 DnaJ domain; Region: DnaJ; pfam00226 483219017302 TPR repeat; Region: TPR_11; pfam13414 483219017303 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219017304 binding surface 483219017305 TPR motif; other site 483219017306 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 483219017307 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 483219017308 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 483219017309 Ligand binding site; other site 483219017310 Putative Catalytic site; other site 483219017311 DXD motif; other site 483219017312 MarC family integral membrane protein; Region: MarC; pfam01914 483219017313 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 483219017314 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 483219017315 ligand binding site [chemical binding]; other site 483219017316 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 483219017317 phosphopeptide binding site; other site 483219017318 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 483219017319 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 483219017320 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219017321 Walker A motif; other site 483219017322 ATP binding site [chemical binding]; other site 483219017323 Walker B motif; other site 483219017324 arginine finger; other site 483219017325 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 483219017326 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219017327 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219017328 active site 483219017329 ATP binding site [chemical binding]; other site 483219017330 substrate binding site [chemical binding]; other site 483219017331 activation loop (A-loop); other site 483219017332 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219017333 binding surface 483219017334 TPR motif; other site 483219017335 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 483219017336 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 483219017337 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 483219017338 active site 483219017339 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 483219017340 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 483219017341 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 483219017342 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 483219017343 trimer interface [polypeptide binding]; other site 483219017344 active site 483219017345 UDP-GlcNAc binding site [chemical binding]; other site 483219017346 lipid binding site [chemical binding]; lipid-binding site 483219017347 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 483219017348 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 483219017349 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 483219017350 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 483219017351 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 483219017352 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 483219017353 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 483219017354 Surface antigen; Region: Bac_surface_Ag; pfam01103 483219017355 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 483219017356 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 483219017357 Walker A/P-loop; other site 483219017358 ATP binding site [chemical binding]; other site 483219017359 Q-loop/lid; other site 483219017360 ABC transporter signature motif; other site 483219017361 Walker B; other site 483219017362 D-loop; other site 483219017363 H-loop/switch region; other site 483219017364 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 483219017365 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 483219017366 FtsX-like permease family; Region: FtsX; pfam02687 483219017367 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 483219017368 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 483219017369 dimer interface [polypeptide binding]; other site 483219017370 putative anticodon binding site; other site 483219017371 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 483219017372 motif 1; other site 483219017373 active site 483219017374 motif 2; other site 483219017375 motif 3; other site 483219017376 Putative zinc-finger; Region: zf-HC2; pfam13490 483219017377 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 483219017378 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 483219017379 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 483219017380 DNA binding residues [nucleotide binding] 483219017381 This domain is found in peptide chain release factors; Region: PCRF; smart00937 483219017382 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 483219017383 RF-1 domain; Region: RF-1; pfam00472 483219017384 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 483219017385 Cupin domain; Region: Cupin_2; pfam07883 483219017386 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 483219017387 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 483219017388 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 483219017389 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 483219017390 Zn2+ binding site [ion binding]; other site 483219017391 Mg2+ binding site [ion binding]; other site 483219017392 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 483219017393 PhoH-like protein; Region: PhoH; pfam02562 483219017394 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 483219017395 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 483219017396 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 483219017397 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 483219017398 homodimer interface [polypeptide binding]; other site 483219017399 metal binding site [ion binding]; metal-binding site 483219017400 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 483219017401 homodimer interface [polypeptide binding]; other site 483219017402 active site 483219017403 putative chemical substrate binding site [chemical binding]; other site 483219017404 metal binding site [ion binding]; metal-binding site 483219017405 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 483219017406 active site 483219017407 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 483219017408 Lipopolysaccharide-assembly; Region: LptE; pfam04390 483219017409 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 483219017410 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 483219017411 HIGH motif; other site 483219017412 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 483219017413 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 483219017414 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 483219017415 active site 483219017416 KMSKS motif; other site 483219017417 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 483219017418 tRNA binding surface [nucleotide binding]; other site 483219017419 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 483219017420 Cna protein B-type domain; Region: Cna_B_2; pfam13715 483219017421 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 483219017422 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 483219017423 starch binding outer membrane protein SusD; Region: SusD; cd08977 483219017424 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 483219017425 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 483219017426 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 483219017427 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 483219017428 Walker A/P-loop; other site 483219017429 ATP binding site [chemical binding]; other site 483219017430 Q-loop/lid; other site 483219017431 ABC transporter signature motif; other site 483219017432 Walker B; other site 483219017433 D-loop; other site 483219017434 H-loop/switch region; other site 483219017435 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219017436 Response regulator receiver domain; Region: Response_reg; pfam00072 483219017437 active site 483219017438 phosphorylation site [posttranslational modification] 483219017439 intermolecular recognition site; other site 483219017440 dimerization interface [polypeptide binding]; other site 483219017441 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 483219017442 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219017443 active site 483219017444 phosphorylation site [posttranslational modification] 483219017445 intermolecular recognition site; other site 483219017446 dimerization interface [polypeptide binding]; other site 483219017447 CheB methylesterase; Region: CheB_methylest; pfam01339 483219017448 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 483219017449 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 483219017450 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 483219017451 HEAT repeats; Region: HEAT_2; pfam13646 483219017452 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 483219017453 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 483219017454 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 483219017455 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 483219017456 putative binding surface; other site 483219017457 active site 483219017458 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 483219017459 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219017460 ATP binding site [chemical binding]; other site 483219017461 Mg2+ binding site [ion binding]; other site 483219017462 G-X-G motif; other site 483219017463 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 483219017464 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 483219017465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219017466 active site 483219017467 phosphorylation site [posttranslational modification] 483219017468 intermolecular recognition site; other site 483219017469 dimerization interface [polypeptide binding]; other site 483219017470 Cytosol aminopeptidase family, N-terminal domain; Region: Peptidase_M17_N; pfam02789 483219017471 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 483219017472 putative RNA binding site [nucleotide binding]; other site 483219017473 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 483219017474 homopentamer interface [polypeptide binding]; other site 483219017475 active site 483219017476 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 483219017477 Lumazine binding domain; Region: Lum_binding; pfam00677 483219017478 Lumazine binding domain; Region: Lum_binding; pfam00677 483219017479 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 483219017480 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 483219017481 catalytic motif [active] 483219017482 Zn binding site [ion binding]; other site 483219017483 RibD C-terminal domain; Region: RibD_C; cl17279 483219017484 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 483219017485 ATP cone domain; Region: ATP-cone; pfam03477 483219017486 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 483219017487 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 483219017488 dimer interface [polypeptide binding]; other site 483219017489 active site 483219017490 glycine-pyridoxal phosphate binding site [chemical binding]; other site 483219017491 folate binding site [chemical binding]; other site 483219017492 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 483219017493 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 483219017494 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 483219017495 dimer interface [polypeptide binding]; other site 483219017496 active site 483219017497 acyl carrier protein; Provisional; Region: acpP; PRK00982 483219017498 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 483219017499 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 483219017500 NAD(P) binding site [chemical binding]; other site 483219017501 homotetramer interface [polypeptide binding]; other site 483219017502 homodimer interface [polypeptide binding]; other site 483219017503 active site 483219017504 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 483219017505 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 483219017506 putative phosphate acyltransferase; Provisional; Region: PRK05331 483219017507 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 483219017508 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 483219017509 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 483219017510 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 483219017511 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219017512 active site 483219017513 phosphorylation site [posttranslational modification] 483219017514 intermolecular recognition site; other site 483219017515 dimerization interface [polypeptide binding]; other site 483219017516 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 483219017517 DNA binding site [nucleotide binding] 483219017518 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 483219017519 PAS domain; Region: PAS; smart00091 483219017520 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219017521 dimer interface [polypeptide binding]; other site 483219017522 phosphorylation site [posttranslational modification] 483219017523 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219017524 ATP binding site [chemical binding]; other site 483219017525 Mg2+ binding site [ion binding]; other site 483219017526 G-X-G motif; other site 483219017527 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 483219017528 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 483219017529 active site 483219017530 metal binding site [ion binding]; metal-binding site 483219017531 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 483219017532 catalytic core [active] 483219017533 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 483219017534 active site clefts [active] 483219017535 zinc binding site [ion binding]; other site 483219017536 dimer interface [polypeptide binding]; other site 483219017537 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 483219017538 Sulfate transporter family; Region: Sulfate_transp; pfam00916 483219017539 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 483219017540 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 483219017541 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219017542 active site 483219017543 phosphorylation site [posttranslational modification] 483219017544 intermolecular recognition site; other site 483219017545 dimerization interface [polypeptide binding]; other site 483219017546 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219017547 Walker A motif; other site 483219017548 ATP binding site [chemical binding]; other site 483219017549 Walker B motif; other site 483219017550 arginine finger; other site 483219017551 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 483219017552 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219017553 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219017554 dimer interface [polypeptide binding]; other site 483219017555 phosphorylation site [posttranslational modification] 483219017556 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219017557 ATP binding site [chemical binding]; other site 483219017558 Mg2+ binding site [ion binding]; other site 483219017559 G-X-G motif; other site 483219017560 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 483219017561 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219017562 active site 483219017563 phosphorylation site [posttranslational modification] 483219017564 intermolecular recognition site; other site 483219017565 dimerization interface [polypeptide binding]; other site 483219017566 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 483219017567 DNA binding site [nucleotide binding] 483219017568 PBP superfamily domain; Region: PBP_like_2; cl17296 483219017569 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 483219017570 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 483219017571 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483219017572 dimer interface [polypeptide binding]; other site 483219017573 conserved gate region; other site 483219017574 putative PBP binding loops; other site 483219017575 ABC-ATPase subunit interface; other site 483219017576 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 483219017577 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483219017578 ABC-ATPase subunit interface; other site 483219017579 phosphate transporter ATP-binding protein; Provisional; Region: PRK14242 483219017580 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 483219017581 Walker A/P-loop; other site 483219017582 ATP binding site [chemical binding]; other site 483219017583 Q-loop/lid; other site 483219017584 ABC transporter signature motif; other site 483219017585 Walker B; other site 483219017586 D-loop; other site 483219017587 H-loop/switch region; other site 483219017588 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 483219017589 PhoU domain; Region: PhoU; pfam01895 483219017590 PhoU domain; Region: PhoU; pfam01895 483219017591 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 483219017592 ligand binding site; other site 483219017593 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 483219017594 Response regulator receiver domain; Region: Response_reg; pfam00072 483219017595 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219017596 active site 483219017597 phosphorylation site [posttranslational modification] 483219017598 intermolecular recognition site; other site 483219017599 dimerization interface [polypeptide binding]; other site 483219017600 Domain of unknown function DUF21; Region: DUF21; pfam01595 483219017601 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 483219017602 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 483219017603 Transporter associated domain; Region: CorC_HlyC; pfam03471 483219017604 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 483219017605 ADP-ribose binding site [chemical binding]; other site 483219017606 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 483219017607 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 483219017608 Interdomain contacts; other site 483219017609 Cytokine receptor motif; other site 483219017610 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 483219017611 Interdomain contacts; other site 483219017612 Cytokine receptor motif; other site 483219017613 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 483219017614 Interdomain contacts; other site 483219017615 Cytokine receptor motif; other site 483219017616 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 483219017617 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 483219017618 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 483219017619 ligand binding site [chemical binding]; other site 483219017620 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 483219017621 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 483219017622 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 483219017623 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 483219017624 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 483219017625 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 483219017626 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 483219017627 type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349 483219017628 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 483219017629 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 483219017630 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 483219017631 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 483219017632 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 483219017633 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 483219017634 Protein of unknown function (DUF770); Region: DUF770; pfam05591 483219017635 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 483219017636 Protein of unknown function (DUF877); Region: DUF877; pfam05943 483219017637 Protein of unknown function (DUF796); Region: DUF796; pfam05638 483219017638 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 483219017639 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 483219017640 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 483219017641 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 483219017642 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 483219017643 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219017644 Walker A motif; other site 483219017645 ATP binding site [chemical binding]; other site 483219017646 Walker B motif; other site 483219017647 arginine finger; other site 483219017648 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219017649 Walker A motif; other site 483219017650 ATP binding site [chemical binding]; other site 483219017651 Walker B motif; other site 483219017652 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 483219017653 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 483219017654 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 483219017655 catalytic residues [active] 483219017656 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 483219017657 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 483219017658 active site 483219017659 catalytic residues [active] 483219017660 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 483219017661 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219017662 Walker A/P-loop; other site 483219017663 ATP binding site [chemical binding]; other site 483219017664 Q-loop/lid; other site 483219017665 ABC transporter signature motif; other site 483219017666 Walker B; other site 483219017667 D-loop; other site 483219017668 H-loop/switch region; other site 483219017669 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 483219017670 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483219017671 dimer interface [polypeptide binding]; other site 483219017672 conserved gate region; other site 483219017673 putative PBP binding loops; other site 483219017674 ABC-ATPase subunit interface; other site 483219017675 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 483219017676 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483219017677 dimer interface [polypeptide binding]; other site 483219017678 conserved gate region; other site 483219017679 putative PBP binding loops; other site 483219017680 ABC-ATPase subunit interface; other site 483219017681 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 483219017682 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 483219017683 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 483219017684 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219017685 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 483219017686 Walker A motif; other site 483219017687 ATP binding site [chemical binding]; other site 483219017688 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219017689 Walker A motif; other site 483219017690 ATP binding site [chemical binding]; other site 483219017691 Walker B motif; other site 483219017692 arginine finger; other site 483219017693 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 483219017694 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 483219017695 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 483219017696 Walker A motif; other site 483219017697 ATP binding site [chemical binding]; other site 483219017698 Walker B motif; other site 483219017699 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219017700 Walker A motif; other site 483219017701 ATP binding site [chemical binding]; other site 483219017702 Walker B motif; other site 483219017703 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 483219017704 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219017705 Walker A motif; other site 483219017706 ATP binding site [chemical binding]; other site 483219017707 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219017708 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 483219017709 Walker A motif; other site 483219017710 ATP binding site [chemical binding]; other site 483219017711 Walker B motif; other site 483219017712 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 483219017713 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 483219017714 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 483219017715 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 483219017716 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 483219017717 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 483219017718 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 483219017719 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 483219017720 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 483219017721 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 483219017722 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 483219017723 catalytic loop [active] 483219017724 iron binding site [ion binding]; other site 483219017725 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 483219017726 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 483219017727 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219017728 Walker A motif; other site 483219017729 ATP binding site [chemical binding]; other site 483219017730 Walker B motif; other site 483219017731 arginine finger; other site 483219017732 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219017733 Walker A motif; other site 483219017734 ATP binding site [chemical binding]; other site 483219017735 Walker B motif; other site 483219017736 arginine finger; other site 483219017737 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 483219017738 Major Facilitator Superfamily; Region: MFS_1; pfam07690 483219017739 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483219017740 putative substrate translocation pore; other site 483219017741 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483219017742 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 483219017743 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 483219017744 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 483219017745 Amidase; Region: Amidase; cl11426 483219017746 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 483219017747 transcriptional regulator; Provisional; Region: PRK10632 483219017748 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 483219017749 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 483219017750 putative effector binding pocket; other site 483219017751 dimerization interface [polypeptide binding]; other site 483219017752 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 483219017753 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 483219017754 ATP binding site [chemical binding]; other site 483219017755 putative Mg++ binding site [ion binding]; other site 483219017756 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 483219017757 nucleotide binding region [chemical binding]; other site 483219017758 ATP-binding site [chemical binding]; other site 483219017759 Pirin-related protein [General function prediction only]; Region: COG1741 483219017760 Pirin; Region: Pirin; pfam02678 483219017761 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 483219017762 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 483219017763 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 483219017764 putative Mg++ binding site [ion binding]; other site 483219017765 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 483219017766 nucleotide binding region [chemical binding]; other site 483219017767 ATP-binding site [chemical binding]; other site 483219017768 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 483219017769 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 483219017770 active site 483219017771 catalytic site [active] 483219017772 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 483219017773 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219017774 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 483219017775 Walker A motif; other site 483219017776 ATP binding site [chemical binding]; other site 483219017777 Walker B motif; other site 483219017778 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 483219017779 Integrase core domain; Region: rve; pfam00665 483219017780 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 483219017781 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 483219017782 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 483219017783 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 483219017784 Helix-turn-helix domain; Region: HTH_17; pfam12728 483219017785 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 483219017786 active site 483219017787 DNA binding site [nucleotide binding] 483219017788 Int/Topo IB signature motif; other site 483219017789 signal recognition particle protein; Provisional; Region: PRK10867 483219017790 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 483219017791 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 483219017792 P loop; other site 483219017793 GTP binding site [chemical binding]; other site 483219017794 Signal peptide binding domain; Region: SRP_SPB; pfam02978 483219017795 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 483219017796 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 483219017797 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 483219017798 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 483219017799 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 483219017800 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219017801 binding surface 483219017802 TPR motif; other site 483219017803 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 483219017804 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219017805 TPR motif; other site 483219017806 binding surface 483219017807 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219017808 binding surface 483219017809 TPR motif; other site 483219017810 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219017811 binding surface 483219017812 TPR motif; other site 483219017813 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219017814 binding surface 483219017815 TPR motif; other site 483219017816 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 483219017817 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 483219017818 phosphopeptide binding site; other site 483219017819 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219017820 binding surface 483219017821 Tetratricopeptide repeat; Region: TPR_16; pfam13432 483219017822 TPR motif; other site 483219017823 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219017824 TPR motif; other site 483219017825 binding surface 483219017826 TPR repeat; Region: TPR_11; pfam13414 483219017827 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219017828 binding surface 483219017829 TPR motif; other site 483219017830 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219017831 binding surface 483219017832 TPR motif; other site 483219017833 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219017834 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 483219017835 Walker A motif; other site 483219017836 ATP binding site [chemical binding]; other site 483219017837 Walker B motif; other site 483219017838 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 483219017839 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 483219017840 Right handed beta helix region; Region: Beta_helix; pfam13229 483219017841 Strictosidine synthase; Region: Str_synth; pfam03088 483219017842 aspartate kinase; Reviewed; Region: PRK06635 483219017843 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 483219017844 putative catalytic residues [active] 483219017845 putative nucleotide binding site [chemical binding]; other site 483219017846 putative aspartate binding site [chemical binding]; other site 483219017847 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 483219017848 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 483219017849 Walker A/P-loop; other site 483219017850 ATP binding site [chemical binding]; other site 483219017851 Q-loop/lid; other site 483219017852 ABC transporter signature motif; other site 483219017853 Walker B; other site 483219017854 D-loop; other site 483219017855 H-loop/switch region; other site 483219017856 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 483219017857 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 483219017858 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 483219017859 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 483219017860 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 483219017861 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 483219017862 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 483219017863 active site 483219017864 metal binding site [ion binding]; metal-binding site 483219017865 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 483219017866 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 483219017867 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 483219017868 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 483219017869 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 483219017870 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483219017871 muropeptide transporter; Reviewed; Region: ampG; PRK11902 483219017872 putative substrate translocation pore; other site 483219017873 phosphoglucomutase; Validated; Region: PRK07564 483219017874 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 483219017875 active site 483219017876 substrate binding site [chemical binding]; other site 483219017877 metal binding site [ion binding]; metal-binding site 483219017878 Predicted membrane protein [Function unknown]; Region: COG4270 483219017879 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 483219017880 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 483219017881 active site 483219017882 Ap6A binding site [chemical binding]; other site 483219017883 nudix motif; other site 483219017884 metal binding site [ion binding]; metal-binding site 483219017885 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 483219017886 oligomerisation interface [polypeptide binding]; other site 483219017887 mobile loop; other site 483219017888 roof hairpin; other site 483219017889 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 483219017890 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 483219017891 ring oligomerisation interface [polypeptide binding]; other site 483219017892 ATP/Mg binding site [chemical binding]; other site 483219017893 stacking interactions; other site 483219017894 hinge regions; other site 483219017895 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 483219017896 GSH binding site [chemical binding]; other site 483219017897 catalytic residues [active] 483219017898 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 483219017899 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 483219017900 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 483219017901 Walker A/P-loop; other site 483219017902 ATP binding site [chemical binding]; other site 483219017903 Q-loop/lid; other site 483219017904 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 483219017905 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 483219017906 ABC transporter signature motif; other site 483219017907 Walker B; other site 483219017908 D-loop; other site 483219017909 H-loop/switch region; other site 483219017910 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 483219017911 Domain of unknown function DUF21; Region: DUF21; pfam01595 483219017912 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 483219017913 Transporter associated domain; Region: CorC_HlyC; smart01091 483219017914 TPR repeat; Region: TPR_11; pfam13414 483219017915 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219017916 binding surface 483219017917 TPR motif; other site 483219017918 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219017919 binding surface 483219017920 TPR motif; other site 483219017921 TPR repeat; Region: TPR_11; pfam13414 483219017922 TPR repeat; Region: TPR_11; pfam13414 483219017923 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219017924 binding surface 483219017925 TPR motif; other site 483219017926 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 483219017927 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 483219017928 putative active site [active] 483219017929 putative metal binding site [ion binding]; other site 483219017930 peptide chain release factor 1; Validated; Region: prfA; PRK00591 483219017931 PCRF domain; Region: PCRF; pfam03462 483219017932 RF-1 domain; Region: RF-1; pfam00472 483219017933 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 483219017934 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219017935 S-adenosylmethionine binding site [chemical binding]; other site 483219017936 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 483219017937 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 483219017938 hinge; other site 483219017939 active site 483219017940 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 483219017941 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 483219017942 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003 483219017943 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 483219017944 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219017945 dimerization interface [polypeptide binding]; other site 483219017946 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 483219017947 cyclase homology domain; Region: CHD; cd07302 483219017948 nucleotidyl binding site; other site 483219017949 metal binding site [ion binding]; metal-binding site 483219017950 dimer interface [polypeptide binding]; other site 483219017951 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219017952 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219017953 active site 483219017954 ATP binding site [chemical binding]; other site 483219017955 substrate binding site [chemical binding]; other site 483219017956 activation loop (A-loop); other site 483219017957 Tetratricopeptide repeat; Region: TPR_12; pfam13424 483219017958 Tetratricopeptide repeat; Region: TPR_12; pfam13424 483219017959 Tetratricopeptide repeat; Region: TPR_10; pfam13374 483219017960 Tetratricopeptide repeat; Region: TPR_12; pfam13424 483219017961 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219017962 binding surface 483219017963 TPR motif; other site 483219017964 RNA polymerase sigma-70 factor, Myxococcales family 1; Region: Sig-70_gmx1; TIGR03001 483219017965 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 483219017966 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 483219017967 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 483219017968 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 483219017969 sugar binding site [chemical binding]; other site 483219017970 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 483219017971 sugar binding site [chemical binding]; other site 483219017972 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 483219017973 sugar binding site [chemical binding]; other site 483219017974 Retinal pigment epithelial membrane protein; Region: RPE65; pfam03055 483219017975 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 483219017976 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 483219017977 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 483219017978 WHG domain; Region: WHG; pfam13305 483219017979 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 483219017980 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 483219017981 Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; Region: EGF_CA; cd00054 483219017982 Ca2+ binding site [ion binding]; other site 483219017983 Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; Region: EGF_CA; cd00054 483219017984 Ca2+ binding site [ion binding]; other site 483219017985 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 483219017986 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 483219017987 FeS/SAM binding site; other site 483219017988 Predicted membrane protein [Function unknown]; Region: COG2261 483219017989 Chalcone-flavanone isomerase; Region: Chalcone; cl03589 483219017990 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 483219017991 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 483219017992 catalytic residue [active] 483219017993 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 483219017994 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 483219017995 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 483219017996 DNA binding residues [nucleotide binding] 483219017997 Caspase domain; Region: Peptidase_C14; pfam00656 483219017998 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 483219017999 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 483219018000 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 483219018001 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 483219018002 hypothetical protein; Provisional; Region: PRK05409 483219018003 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 483219018004 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 483219018005 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 483219018006 non-specific DNA binding site [nucleotide binding]; other site 483219018007 salt bridge; other site 483219018008 sequence-specific DNA binding site [nucleotide binding]; other site 483219018009 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 483219018010 Domain of unknown function (DUF955); Region: DUF955; pfam06114 483219018011 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 483219018012 Tetratricopeptide repeat; Region: TPR_12; pfam13424 483219018013 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219018014 binding surface 483219018015 TPR motif; other site 483219018016 Tetratricopeptide repeat; Region: TPR_12; pfam13424 483219018017 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 483219018018 multifunctional aminopeptidase A; Provisional; Region: PRK00913 483219018019 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 483219018020 interface (dimer of trimers) [polypeptide binding]; other site 483219018021 Substrate-binding/catalytic site; other site 483219018022 Zn-binding sites [ion binding]; other site 483219018023 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 483219018024 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 483219018025 Thioredoxin; Region: Thioredoxin_4; pfam13462 483219018026 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 483219018027 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 483219018028 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 483219018029 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219018030 Walker A motif; other site 483219018031 ATP binding site [chemical binding]; other site 483219018032 Walker B motif; other site 483219018033 arginine finger; other site 483219018034 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 483219018035 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 483219018036 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 483219018037 RuvA N terminal domain; Region: RuvA_N; pfam01330 483219018038 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 483219018039 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280 483219018040 putative DNA-binding cleft [nucleotide binding]; other site 483219018041 dimer interface [polypeptide binding]; other site 483219018042 active site 483219018043 hypothetical protein; Validated; Region: PRK00110 483219018044 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 483219018045 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219018046 active site 483219018047 phosphorylation site [posttranslational modification] 483219018048 intermolecular recognition site; other site 483219018049 dimerization interface [polypeptide binding]; other site 483219018050 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 483219018051 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 483219018052 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219018053 active site 483219018054 phosphorylation site [posttranslational modification] 483219018055 intermolecular recognition site; other site 483219018056 dimerization interface [polypeptide binding]; other site 483219018057 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219018058 Walker A motif; other site 483219018059 ATP binding site [chemical binding]; other site 483219018060 Walker B motif; other site 483219018061 arginine finger; other site 483219018062 CARDB; Region: CARDB; pfam07705 483219018063 CARDB; Region: CARDB; pfam07705 483219018064 CARDB; Region: CARDB; pfam07705 483219018065 CARDB; Region: CARDB; pfam07705 483219018066 CARDB; Region: CARDB; pfam07705 483219018067 CARDB; Region: CARDB; pfam07705 483219018068 CARDB; Region: CARDB; pfam07705 483219018069 CARDB; Region: CARDB; pfam07705 483219018070 CARDB; Region: CARDB; pfam07705 483219018071 CARDB; Region: CARDB; pfam07705 483219018072 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 483219018073 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 483219018074 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 483219018075 putative active site [active] 483219018076 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 483219018077 hypothetical protein; Reviewed; Region: PRK09588 483219018078 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 483219018079 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 483219018080 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219018081 Walker A motif; other site 483219018082 ATP binding site [chemical binding]; other site 483219018083 Walker B motif; other site 483219018084 arginine finger; other site 483219018085 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 483219018086 active site 483219018087 Putative zinc-finger; Region: zf-HC2; pfam13490 483219018088 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219018089 binding surface 483219018090 TPR motif; other site 483219018091 Tetratricopeptide repeat; Region: TPR_16; pfam13432 483219018092 CHAT domain; Region: CHAT; cl17868 483219018093 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 483219018094 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 483219018095 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 483219018096 DNA binding residues [nucleotide binding] 483219018097 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219018098 dimer interface [polypeptide binding]; other site 483219018099 phosphorylation site [posttranslational modification] 483219018100 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219018101 ATP binding site [chemical binding]; other site 483219018102 G-X-G motif; other site 483219018103 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 483219018104 DTW domain; Region: DTW; cl01221 483219018105 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 483219018106 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 483219018107 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 483219018108 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 483219018109 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cd02106 483219018110 cysteine desulfurase; Provisional; Region: PRK14012 483219018111 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 483219018112 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 483219018113 catalytic residue [active] 483219018114 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 483219018115 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 483219018116 trimerization site [polypeptide binding]; other site 483219018117 active site 483219018118 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 483219018119 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 483219018120 HSP70 interaction site [polypeptide binding]; other site 483219018121 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 483219018122 chaperone protein HscA; Provisional; Region: hscA; PRK05183 483219018123 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 483219018124 nucleotide binding site [chemical binding]; other site 483219018125 putative NEF/HSP70 interaction site [polypeptide binding]; other site 483219018126 SBD interface [polypeptide binding]; other site 483219018127 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 483219018128 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 483219018129 catalytic loop [active] 483219018130 iron binding site [ion binding]; other site 483219018131 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 483219018132 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 483219018133 Surface antigen; Region: Bac_surface_Ag; pfam01103 483219018134 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 483219018135 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 483219018136 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 483219018137 catalytic residue [active] 483219018138 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 483219018139 putative catalytic site [active] 483219018140 putative metal binding site [ion binding]; other site 483219018141 putative phosphate binding site [ion binding]; other site 483219018142 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 483219018143 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 483219018144 diphosphomevalonate decarboxylase; Region: PLN02407 483219018145 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 483219018146 mevalonate kinase; Region: mevalon_kin; TIGR00549 483219018147 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 483219018148 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 483219018149 homodimer interface [polypeptide binding]; other site 483219018150 catalytic residues [active] 483219018151 NAD binding site [chemical binding]; other site 483219018152 substrate binding pocket [chemical binding]; other site 483219018153 flexible flap; other site 483219018154 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 483219018155 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 483219018156 homotetramer interface [polypeptide binding]; other site 483219018157 FMN binding site [chemical binding]; other site 483219018158 homodimer contacts [polypeptide binding]; other site 483219018159 putative active site [active] 483219018160 putative substrate binding site [chemical binding]; other site 483219018161 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 483219018162 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 483219018163 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 483219018164 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 483219018165 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 483219018166 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 483219018167 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 483219018168 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 483219018169 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 483219018170 Imelysin; Region: Peptidase_M75; pfam09375 483219018171 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 483219018172 Peptidase family M48; Region: Peptidase_M48; cl12018 483219018173 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 483219018174 Transcriptional regulators [Transcription]; Region: MarR; COG1846 483219018175 MarR family; Region: MarR_2; pfam12802 483219018176 MarR family; Region: MarR_2; cl17246 483219018177 Outer membrane efflux protein; Region: OEP; pfam02321 483219018178 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 483219018179 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 483219018180 HlyD family secretion protein; Region: HlyD_3; pfam13437 483219018181 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 483219018182 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219018183 dimerization interface [polypeptide binding]; other site 483219018184 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219018185 dimer interface [polypeptide binding]; other site 483219018186 phosphorylation site [posttranslational modification] 483219018187 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219018188 ATP binding site [chemical binding]; other site 483219018189 Mg2+ binding site [ion binding]; other site 483219018190 G-X-G motif; other site 483219018191 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 483219018192 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 483219018193 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 483219018194 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219018195 binding surface 483219018196 TPR motif; other site 483219018197 Surface antigen; Region: Bac_surface_Ag; pfam01103 483219018198 Protein of unknown function (DUF819); Region: DUF819; cl02317 483219018199 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 483219018200 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 483219018201 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 483219018202 catalytic residue [active] 483219018203 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 483219018204 Protein of unknown function (DUF779); Region: DUF779; pfam05610 483219018205 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 483219018206 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 483219018207 NAD(P) binding site [chemical binding]; other site 483219018208 catalytic residues [active] 483219018209 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219018210 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 483219018211 Walker A motif; other site 483219018212 ATP binding site [chemical binding]; other site 483219018213 Walker B motif; other site 483219018214 arginine finger; other site 483219018215 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 483219018216 DNA-binding interface [nucleotide binding]; DNA binding site 483219018217 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 483219018218 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 483219018219 ligand binding site [chemical binding]; other site 483219018220 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 483219018221 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 483219018222 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 483219018223 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 483219018224 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 483219018225 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 483219018226 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 483219018227 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 483219018228 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 483219018229 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 483219018230 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 483219018231 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 483219018232 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 483219018233 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 483219018234 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 483219018235 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 483219018236 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 483219018237 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 483219018238 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 483219018239 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219018240 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219018241 active site 483219018242 ATP binding site [chemical binding]; other site 483219018243 substrate binding site [chemical binding]; other site 483219018244 activation loop (A-loop); other site 483219018245 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 483219018246 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219018247 Walker A motif; other site 483219018248 ATP binding site [chemical binding]; other site 483219018249 Walker B motif; other site 483219018250 arginine finger; other site 483219018251 Response regulator receiver domain; Region: Response_reg; pfam00072 483219018252 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219018253 active site 483219018254 phosphorylation site [posttranslational modification] 483219018255 intermolecular recognition site; other site 483219018256 dimerization interface [polypeptide binding]; other site 483219018257 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 483219018258 Response regulator receiver domain; Region: Response_reg; pfam00072 483219018259 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219018260 active site 483219018261 phosphorylation site [posttranslational modification] 483219018262 intermolecular recognition site; other site 483219018263 dimerization interface [polypeptide binding]; other site 483219018264 GAF domain; Region: GAF_3; pfam13492 483219018265 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 483219018266 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 483219018267 metal binding site [ion binding]; metal-binding site 483219018268 active site 483219018269 I-site; other site 483219018270 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 483219018271 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 483219018272 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 483219018273 Methyltransferase domain; Region: Methyltransf_11; pfam08241 483219018274 ribonucleoside--diphosphate reductase large subunit; Region: PLN02437 483219018275 ATP cone domain; Region: ATP-cone; pfam03477 483219018276 Class I ribonucleotide reductase; Region: RNR_I; cd01679 483219018277 active site 483219018278 dimer interface [polypeptide binding]; other site 483219018279 catalytic residues [active] 483219018280 effector binding site; other site 483219018281 R2 peptide binding site; other site 483219018282 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 483219018283 dimer interface [polypeptide binding]; other site 483219018284 putative radical transfer pathway; other site 483219018285 diiron center [ion binding]; other site 483219018286 tyrosyl radical; other site 483219018287 Transposase, Mutator family; Region: Transposase_mut; pfam00872 483219018288 MULE transposase domain; Region: MULE; pfam10551 483219018289 Transposase, Mutator family; Region: Transposase_mut; pfam00872 483219018290 P63C domain; Region: P63C; pfam10546 483219018291 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 483219018292 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 483219018293 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 483219018294 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219018295 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 483219018296 Walker A motif; other site 483219018297 ATP binding site [chemical binding]; other site 483219018298 Walker B motif; other site 483219018299 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 483219018300 Integrase core domain; Region: rve; pfam00665 483219018301 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 483219018302 Phospholipid methyltransferase; Region: PEMT; pfam04191 483219018303 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 483219018304 Peptidase S8 family domain, uncharacterized subfamily 12; Region: Peptidases_S8_12; cd07480 483219018305 active site 483219018306 catalytic triad [active] 483219018307 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 483219018308 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 483219018309 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 483219018310 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 483219018311 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 483219018312 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 483219018313 conserved hypothetical protein; Region: TIGR02270 483219018314 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 483219018315 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 483219018316 amphipathic channel; other site 483219018317 Asn-Pro-Ala signature motifs; other site 483219018318 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 483219018319 active site 483219018320 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 483219018321 thymidine kinase; Provisional; Region: PRK04296 483219018322 regulatory protein SpoVG; Reviewed; Region: PRK13259 483219018323 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 483219018324 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 483219018325 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 483219018326 active site 483219018327 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 483219018328 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 483219018329 5S rRNA interface [nucleotide binding]; other site 483219018330 CTC domain interface [polypeptide binding]; other site 483219018331 L16 interface [polypeptide binding]; other site 483219018332 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 483219018333 putative active site [active] 483219018334 catalytic residue [active] 483219018335 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 483219018336 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 483219018337 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 483219018338 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 483219018339 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 483219018340 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 483219018341 replicative DNA helicase; Region: DnaB; TIGR00665 483219018342 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 483219018343 Walker A motif; other site 483219018344 ATP binding site [chemical binding]; other site 483219018345 Walker B motif; other site 483219018346 DNA binding loops [nucleotide binding] 483219018347 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 483219018348 ATP binding site [chemical binding]; other site 483219018349 substrate binding site [chemical binding]; other site 483219018350 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 483219018351 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 483219018352 catalytic triad [active] 483219018353 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 483219018354 active site 483219018355 thiamine phosphate binding site [chemical binding]; other site 483219018356 pyrophosphate binding site [ion binding]; other site 483219018357 Domain of unknown function (DUF1844); Region: DUF1844; pfam08899 483219018358 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 483219018359 Clp amino terminal domain; Region: Clp_N; pfam02861 483219018360 Clp amino terminal domain; Region: Clp_N; pfam02861 483219018361 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219018362 Walker A motif; other site 483219018363 ATP binding site [chemical binding]; other site 483219018364 Walker B motif; other site 483219018365 arginine finger; other site 483219018366 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219018367 Walker A motif; other site 483219018368 ATP binding site [chemical binding]; other site 483219018369 Walker B motif; other site 483219018370 arginine finger; other site 483219018371 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 483219018372 Methyltransferase domain; Region: Methyltransf_26; pfam13659 483219018373 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 483219018374 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 483219018375 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 483219018376 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 483219018377 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 483219018378 Protein of unknown function (DUF418); Region: DUF418; cl12135 483219018379 Protein of unknown function (DUF418); Region: DUF418; pfam04235 483219018380 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 483219018381 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 483219018382 metal binding site [ion binding]; metal-binding site 483219018383 putative dimer interface [polypeptide binding]; other site 483219018384 Putative Ig domain; Region: He_PIG; pfam05345 483219018385 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 483219018386 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 483219018387 DNA binding residues [nucleotide binding] 483219018388 Arginine repressor [Transcription]; Region: ArgR; COG1438 483219018389 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 483219018390 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 483219018391 N-acetylornithine carbamoyltransferase; Reviewed; Region: PRK04523 483219018392 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 483219018393 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 483219018394 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 483219018395 nucleotide binding site [chemical binding]; other site 483219018396 substrate binding site [chemical binding]; other site 483219018397 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 483219018398 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 483219018399 metal binding site [ion binding]; metal-binding site 483219018400 Lyase; Region: Lyase_1; pfam00206 483219018401 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 483219018402 active sites [active] 483219018403 tetramer interface [polypeptide binding]; other site 483219018404 argininosuccinate synthase; Provisional; Region: PRK13820 483219018405 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 483219018406 Ligand Binding Site [chemical binding]; other site 483219018407 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 483219018408 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 483219018409 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 483219018410 Uncharacterized conserved protein [Function unknown]; Region: COG0398 483219018411 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 483219018412 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 483219018413 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 483219018414 Patatin-like phospholipase; Region: Patatin; pfam01734 483219018415 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 483219018416 Ligand Binding Site [chemical binding]; other site 483219018417 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 483219018418 Ligand Binding Site [chemical binding]; other site 483219018419 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 483219018420 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 483219018421 dimerization interface 3.5A [polypeptide binding]; other site 483219018422 active site 483219018423 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219018424 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 483219018425 active site 483219018426 ATP binding site [chemical binding]; other site 483219018427 substrate binding site [chemical binding]; other site 483219018428 activation loop (A-loop); other site 483219018429 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 483219018430 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 483219018431 putative RNA binding site [nucleotide binding]; other site 483219018432 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219018433 S-adenosylmethionine binding site [chemical binding]; other site 483219018434 putative selenium metabolism protein SsnA; Region: Se_ssnA; TIGR03314 483219018435 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 483219018436 active site 483219018437 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 483219018438 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 483219018439 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 483219018440 DNA binding residues [nucleotide binding] 483219018441 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 483219018442 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 483219018443 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219018444 S-adenosylmethionine binding site [chemical binding]; other site 483219018445 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219018446 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219018447 dimer interface [polypeptide binding]; other site 483219018448 phosphorylation site [posttranslational modification] 483219018449 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 483219018450 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219018451 active site 483219018452 phosphorylation site [posttranslational modification] 483219018453 intermolecular recognition site; other site 483219018454 dimerization interface [polypeptide binding]; other site 483219018455 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219018456 Walker A motif; other site 483219018457 ATP binding site [chemical binding]; other site 483219018458 Walker B motif; other site 483219018459 arginine finger; other site 483219018460 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 483219018461 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 483219018462 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 483219018463 ligand binding site [chemical binding]; other site 483219018464 flexible hinge region; other site 483219018465 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 483219018466 putative switch regulator; other site 483219018467 non-specific DNA interactions [nucleotide binding]; other site 483219018468 DNA binding site [nucleotide binding] 483219018469 sequence specific DNA binding site [nucleotide binding]; other site 483219018470 putative cAMP binding site [chemical binding]; other site 483219018471 phenylalanine 4-monooxygenase; Provisional; Region: PRK14056 483219018472 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 483219018473 cofactor binding site; other site 483219018474 metal binding site [ion binding]; metal-binding site 483219018475 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 483219018476 Transcriptional regulator [Transcription]; Region: LysR; COG0583 483219018477 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 483219018478 dimerization interface [polypeptide binding]; other site 483219018479 Sulfatase; Region: Sulfatase; cl17466 483219018480 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 483219018481 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 483219018482 active site 483219018483 metal binding site [ion binding]; metal-binding site 483219018484 HEAT repeats; Region: HEAT_2; pfam13646 483219018485 HEAT repeats; Region: HEAT_2; pfam13646 483219018486 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 483219018487 metal ion-dependent adhesion site (MIDAS); other site 483219018488 MutS domain III; Region: MutS_III; pfam05192 483219018489 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219018490 Walker A/P-loop; other site 483219018491 ATP binding site [chemical binding]; other site 483219018492 Q-loop/lid; other site 483219018493 ABC transporter signature motif; other site 483219018494 Walker B; other site 483219018495 D-loop; other site 483219018496 H-loop/switch region; other site 483219018497 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 483219018498 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 483219018499 dimer interface [polypeptide binding]; other site 483219018500 active site 483219018501 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 483219018502 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 483219018503 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 483219018504 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 483219018505 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 483219018506 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 483219018507 substrate binding site [chemical binding]; other site 483219018508 oxyanion hole (OAH) forming residues; other site 483219018509 trimer interface [polypeptide binding]; other site 483219018510 leukotriene A-4 hydrolase/aminopeptidase; Region: leuko_A4_hydro; TIGR02411 483219018511 Peptidase M1 family contains leukotriene A4 hydrolase; Region: M1_LTA4H; cd09599 483219018512 active site 483219018513 Zn binding site [ion binding]; other site 483219018514 Leukotriene A4 hydrolase, C-terminal; Region: Leuk-A4-hydro_C; pfam09127 483219018515 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 483219018516 DNA methylase; Region: N6_N4_Mtase; pfam01555 483219018517 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 483219018518 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 483219018519 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219018520 binding surface 483219018521 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 483219018522 TPR motif; other site 483219018523 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 483219018524 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219018525 S-adenosylmethionine binding site [chemical binding]; other site 483219018526 TPR repeat; Region: TPR_11; pfam13414 483219018527 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 483219018528 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219018529 active site 483219018530 phosphorylation site [posttranslational modification] 483219018531 intermolecular recognition site; other site 483219018532 dimerization interface [polypeptide binding]; other site 483219018533 CheB methylesterase; Region: CheB_methylest; pfam01339 483219018534 Protein of unknown function (DUF2381); Region: DUF2381; cl15442 483219018535 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 483219018536 putative binding surface; other site 483219018537 active site 483219018538 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219018539 ATP binding site [chemical binding]; other site 483219018540 Mg2+ binding site [ion binding]; other site 483219018541 G-X-G motif; other site 483219018542 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 483219018543 Response regulator receiver domain; Region: Response_reg; pfam00072 483219018544 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219018545 active site 483219018546 phosphorylation site [posttranslational modification] 483219018547 intermolecular recognition site; other site 483219018548 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219018549 dimerization interface [polypeptide binding]; other site 483219018550 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 483219018551 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 483219018552 dimer interface [polypeptide binding]; other site 483219018553 putative CheW interface [polypeptide binding]; other site 483219018554 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 483219018555 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 483219018556 dimer interface [polypeptide binding]; other site 483219018557 putative CheW interface [polypeptide binding]; other site 483219018558 CheW-like domain; Region: CheW; pfam01584 483219018559 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 483219018560 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 483219018561 ligand binding site [chemical binding]; other site 483219018562 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 483219018563 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219018564 active site 483219018565 phosphorylation site [posttranslational modification] 483219018566 intermolecular recognition site; other site 483219018567 dimerization interface [polypeptide binding]; other site 483219018568 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219018569 Walker A motif; other site 483219018570 ATP binding site [chemical binding]; other site 483219018571 Walker B motif; other site 483219018572 arginine finger; other site 483219018573 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 483219018574 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 483219018575 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 483219018576 AzlC protein; Region: AzlC; pfam03591 483219018577 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 483219018578 MreB/Mbl protein; Region: MreB_Mbl; pfam06723 483219018579 nucleotide binding site [chemical binding]; other site 483219018580 putative NEF/HSP70 interaction site [polypeptide binding]; other site 483219018581 SBD interface [polypeptide binding]; other site 483219018582 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 483219018583 putative DNA binding site [nucleotide binding]; other site 483219018584 Transcriptional regulators [Transcription]; Region: MarR; COG1846 483219018585 putative Zn2+ binding site [ion binding]; other site 483219018586 Predicted membrane protein [Function unknown]; Region: COG2259 483219018587 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 483219018588 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 483219018589 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 483219018590 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 483219018591 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 483219018592 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 483219018593 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 483219018594 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 483219018595 ligand binding site [chemical binding]; other site 483219018596 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 483219018597 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 483219018598 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 483219018599 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase; Region: M28_AAP; cd03879 483219018600 Peptidase family M28; Region: Peptidase_M28; pfam04389 483219018601 active site 483219018602 metal binding site [ion binding]; metal-binding site 483219018603 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 483219018604 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 483219018605 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 483219018606 Walker A/P-loop; other site 483219018607 ATP binding site [chemical binding]; other site 483219018608 Q-loop/lid; other site 483219018609 ABC transporter signature motif; other site 483219018610 Walker B; other site 483219018611 D-loop; other site 483219018612 H-loop/switch region; other site 483219018613 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 483219018614 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 483219018615 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 483219018616 FtsX-like permease family; Region: FtsX; pfam02687 483219018617 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 483219018618 Radical SAM superfamily; Region: Radical_SAM; pfam04055 483219018619 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 483219018620 FeS/SAM binding site; other site 483219018621 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 483219018622 HEXXH motif domain; Region: mod_HExxH; TIGR04267 483219018623 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 483219018624 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 483219018625 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 483219018626 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 483219018627 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 483219018628 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219018629 active site 483219018630 ATP binding site [chemical binding]; other site 483219018631 substrate binding site [chemical binding]; other site 483219018632 activation loop (A-loop); other site 483219018633 Predicted integral membrane protein [Function unknown]; Region: COG5616 483219018634 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 483219018635 putative catalytic site [active] 483219018636 putative phosphate binding site [ion binding]; other site 483219018637 active site 483219018638 metal binding site A [ion binding]; metal-binding site 483219018639 DNA binding site [nucleotide binding] 483219018640 putative AP binding site [nucleotide binding]; other site 483219018641 putative metal binding site B [ion binding]; other site 483219018642 TPR repeat; Region: TPR_11; pfam13414 483219018643 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219018644 binding surface 483219018645 TPR motif; other site 483219018646 TPR repeat; Region: TPR_11; pfam13414 483219018647 Transglycosylase; Region: Transgly; pfam00912 483219018648 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 483219018649 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 483219018650 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219018651 dimerization interface [polypeptide binding]; other site 483219018652 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219018653 dimer interface [polypeptide binding]; other site 483219018654 phosphorylation site [posttranslational modification] 483219018655 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219018656 ATP binding site [chemical binding]; other site 483219018657 Mg2+ binding site [ion binding]; other site 483219018658 G-X-G motif; other site 483219018659 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 483219018660 30S subunit binding site; other site 483219018661 Response regulator receiver domain; Region: Response_reg; pfam00072 483219018662 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219018663 active site 483219018664 phosphorylation site [posttranslational modification] 483219018665 intermolecular recognition site; other site 483219018666 dimerization interface [polypeptide binding]; other site 483219018667 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 483219018668 HEAT repeats; Region: HEAT_2; pfam13646 483219018669 HEAT repeats; Region: HEAT_2; pfam13646 483219018670 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 483219018671 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 483219018672 ligand binding site [chemical binding]; other site 483219018673 tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142 483219018674 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 483219018675 Permutation of conserved domain; other site 483219018676 active site 483219018677 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 483219018678 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 483219018679 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 483219018680 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 483219018681 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 483219018682 homodimer interface [polypeptide binding]; other site 483219018683 active site 483219018684 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 483219018685 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 483219018686 phosphopeptide binding site; other site 483219018687 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 483219018688 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 483219018689 metal binding site [ion binding]; metal-binding site 483219018690 active site 483219018691 I-site; other site 483219018692 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 483219018693 Yqey-like protein; Region: YqeY; pfam09424 483219018694 DNA primase, catalytic core; Region: dnaG; TIGR01391 483219018695 CHC2 zinc finger; Region: zf-CHC2; pfam01807 483219018696 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 483219018697 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 483219018698 active site 483219018699 metal binding site [ion binding]; metal-binding site 483219018700 interdomain interaction site; other site 483219018701 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 483219018702 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 483219018703 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 483219018704 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 483219018705 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 483219018706 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 483219018707 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 483219018708 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 483219018709 DNA binding residues [nucleotide binding] 483219018710 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 483219018711 DNA binding site [nucleotide binding] 483219018712 active site 483219018713 Protein of unknown function (DUF3175); Region: DUF3175; pfam11373 483219018714 HflX GTPase family; Region: HflX; cd01878 483219018715 G1 box; other site 483219018716 GTP/Mg2+ binding site [chemical binding]; other site 483219018717 Switch I region; other site 483219018718 G2 box; other site 483219018719 G3 box; other site 483219018720 Switch II region; other site 483219018721 G4 box; other site 483219018722 G5 box; other site 483219018723 CAAX protease self-immunity; Region: Abi; pfam02517 483219018724 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 483219018725 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 483219018726 active site 483219018727 Dual-action HEIGH metallo-peptidase; Region: Peptidase_M57; pfam12388 483219018728 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 483219018729 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 483219018730 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 483219018731 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 483219018732 large tegument protein UL36; Provisional; Region: PHA03247 483219018733 LVIVD repeat; Region: LVIVD; pfam08309 483219018734 Uncharacterized conserved protein [Function unknown]; Region: COG5276 483219018735 LVIVD repeat; Region: LVIVD; pfam08309 483219018736 YCII-related domain; Region: YCII; cl00999 483219018737 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 483219018738 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 483219018739 Beta-lactamase; Region: Beta-lactamase; pfam00144 483219018740 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 483219018741 putative substrate binding site [chemical binding]; other site 483219018742 active site 483219018743 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 483219018744 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 483219018745 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 483219018746 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 483219018747 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 483219018748 active site 483219018749 Zn binding site [ion binding]; other site 483219018750 DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]; Region: NUC1; COG1864 483219018751 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 483219018752 active site 483219018753 substrate binding site [chemical binding]; other site 483219018754 Mg2+ binding site [ion binding]; other site 483219018755 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 483219018756 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 483219018757 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 483219018758 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 483219018759 Peptidase S8 family domain, uncharacterized subfamily 12; Region: Peptidases_S8_12; cd07480 483219018760 active site 483219018761 catalytic triad [active] 483219018762 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 483219018763 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 483219018764 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 483219018765 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 483219018766 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 483219018767 putative hydrophobic ligand binding site [chemical binding]; other site 483219018768 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 483219018769 dimerization interface [polypeptide binding]; other site 483219018770 putative DNA binding site [nucleotide binding]; other site 483219018771 putative Zn2+ binding site [ion binding]; other site 483219018772 H+ Antiporter protein; Region: 2A0121; TIGR00900 483219018773 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483219018774 putative substrate translocation pore; other site 483219018775 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 483219018776 generic binding surface I; other site 483219018777 generic binding surface II; other site 483219018778 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 483219018779 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 483219018780 sugar binding site [chemical binding]; other site 483219018781 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 483219018782 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 483219018783 Peptidase family M28; Region: Peptidase_M28; pfam04389 483219018784 metal binding site [ion binding]; metal-binding site 483219018785 Domain of unknown function (DUF3943); Region: DUF3943; pfam13084 483219018786 Procyclic acidic repetitive protein (PARP); Region: Trypan_PARP; pfam05887 483219018787 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 483219018788 SIR2-like domain; Region: SIR2_2; pfam13289 483219018789 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 483219018790 Transposase, Mutator family; Region: Transposase_mut; pfam00872 483219018791 MULE transposase domain; Region: MULE; pfam10551 483219018792 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219018793 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219018794 active site 483219018795 ATP binding site [chemical binding]; other site 483219018796 substrate binding site [chemical binding]; other site 483219018797 activation loop (A-loop); other site 483219018798 Transposase, Mutator family; Region: Transposase_mut; pfam00872 483219018799 MULE transposase domain; Region: MULE; pfam10551 483219018800 Phage integrase family; Region: Phage_integrase; pfam00589 483219018801 active site 483219018802 DNA binding site [nucleotide binding] 483219018803 Int/Topo IB signature motif; other site 483219018804 PEGA domain; Region: PEGA; pfam08308 483219018805 Helix-turn-helix domain; Region: HTH_28; pfam13518 483219018806 Winged helix-turn helix; Region: HTH_29; pfam13551 483219018807 Winged helix-turn helix; Region: HTH_33; pfam13592 483219018808 DDE superfamily endonuclease; Region: DDE_3; pfam13358 483219018809 Transglycosylase; Region: Transgly; pfam00912 483219018810 Domain of unknown function (DUF4034); Region: DUF4034; pfam13226 483219018811 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 483219018812 TPR motif; other site 483219018813 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 483219018814 Uncharacterized conserved protein [Function unknown]; Region: COG3391 483219018815 AAA ATPase domain; Region: AAA_16; pfam13191 483219018816 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 483219018817 DNA binding residues [nucleotide binding] 483219018818 dimerization interface [polypeptide binding]; other site 483219018819 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 483219018820 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 483219018821 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 483219018822 Cupin domain; Region: Cupin_2; pfam07883 483219018823 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 483219018824 DNA-binding site [nucleotide binding]; DNA binding site 483219018825 RNA-binding motif; other site 483219018826 Heavy-metal resistance; Region: Metal_resist; pfam13801 483219018827 dimer interface [polypeptide binding]; other site 483219018828 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 483219018829 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219018830 active site 483219018831 phosphorylation site [posttranslational modification] 483219018832 intermolecular recognition site; other site 483219018833 dimerization interface [polypeptide binding]; other site 483219018834 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 483219018835 DNA binding site [nucleotide binding] 483219018836 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 483219018837 dimerization interface [polypeptide binding]; other site 483219018838 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219018839 dimer interface [polypeptide binding]; other site 483219018840 phosphorylation site [posttranslational modification] 483219018841 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219018842 ATP binding site [chemical binding]; other site 483219018843 Mg2+ binding site [ion binding]; other site 483219018844 G-X-G motif; other site 483219018845 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 483219018846 ABC-2 type transporter; Region: ABC2_membrane; cl17235 483219018847 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 483219018848 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 483219018849 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219018850 Walker A/P-loop; other site 483219018851 ATP binding site [chemical binding]; other site 483219018852 Q-loop/lid; other site 483219018853 ABC transporter signature motif; other site 483219018854 Walker B; other site 483219018855 D-loop; other site 483219018856 H-loop/switch region; other site 483219018857 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 483219018858 UbiA prenyltransferase family; Region: UbiA; pfam01040 483219018859 TPR repeat; Region: TPR_11; pfam13414 483219018860 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219018861 binding surface 483219018862 TPR motif; other site 483219018863 TPR repeat; Region: TPR_11; pfam13414 483219018864 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219018865 TPR motif; other site 483219018866 binding surface 483219018867 TPR repeat; Region: TPR_11; pfam13414 483219018868 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219018869 TPR motif; other site 483219018870 binding surface 483219018871 Tetratricopeptide repeat; Region: TPR_12; pfam13424 483219018872 TPR repeat; Region: TPR_11; pfam13414 483219018873 Domain of unknown function (DUF2760); Region: DUF2760; pfam10816 483219018874 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 483219018875 nucleotide binding site [chemical binding]; other site 483219018876 putative NEF/HSP70 interaction site [polypeptide binding]; other site 483219018877 SBD interface [polypeptide binding]; other site 483219018878 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 483219018879 nucleotide binding site [chemical binding]; other site 483219018880 putative NEF/HSP70 interaction site [polypeptide binding]; other site 483219018881 SBD interface [polypeptide binding]; other site 483219018882 DNA-K related protein; Region: DUF3731; pfam12531 483219018883 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 483219018884 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 483219018885 active site 483219018886 metal binding site [ion binding]; metal-binding site 483219018887 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 483219018888 Phytase; Region: Phytase; cl17685 483219018889 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 483219018890 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 483219018891 NADP-binding site; other site 483219018892 homotetramer interface [polypeptide binding]; other site 483219018893 substrate binding site [chemical binding]; other site 483219018894 homodimer interface [polypeptide binding]; other site 483219018895 active site 483219018896 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 483219018897 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 483219018898 NADP-binding site; other site 483219018899 homotetramer interface [polypeptide binding]; other site 483219018900 substrate binding site [chemical binding]; other site 483219018901 homodimer interface [polypeptide binding]; other site 483219018902 active site 483219018903 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 483219018904 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 483219018905 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 483219018906 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 483219018907 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 483219018908 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 483219018909 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 483219018910 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 483219018911 Ligand binding site; other site 483219018912 Ligand binding site; other site 483219018913 Ligand binding site; other site 483219018914 Putative Catalytic site; other site 483219018915 DXD motif; other site 483219018916 putative bifunctional glutamate synthase subunit beta/2-polyprenylphenol hydroxylase; Validated; Region: PRK06567 483219018917 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192 483219018918 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 483219018919 FAD binding pocket [chemical binding]; other site 483219018920 FAD binding motif [chemical binding]; other site 483219018921 phosphate binding motif [ion binding]; other site 483219018922 beta-alpha-beta structure motif; other site 483219018923 NAD binding pocket [chemical binding]; other site 483219018924 Iron coordination center [ion binding]; other site 483219018925 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 483219018926 catalytic core [active] 483219018927 iron donor protein CyaY; Region: FeS_CyaY; TIGR03421 483219018928 putative iron binding site [ion binding]; other site 483219018929 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 483219018930 intermolecular recognition site; other site 483219018931 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 483219018932 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 483219018933 metal binding site [ion binding]; metal-binding site 483219018934 active site 483219018935 I-site; other site 483219018936 ribosome recycling factor; Reviewed; Region: frr; PRK00083 483219018937 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 483219018938 hinge region; other site 483219018939 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 483219018940 putative nucleotide binding site [chemical binding]; other site 483219018941 uridine monophosphate binding site [chemical binding]; other site 483219018942 homohexameric interface [polypeptide binding]; other site 483219018943 elongation factor Ts; Reviewed; Region: tsf; PRK12332 483219018944 UBA/TS-N domain; Region: UBA; pfam00627 483219018945 Elongation factor TS; Region: EF_TS; pfam00889 483219018946 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 483219018947 rRNA interaction site [nucleotide binding]; other site 483219018948 S8 interaction site; other site 483219018949 putative laminin-1 binding site; other site 483219018950 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 483219018951 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 483219018952 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 483219018953 nucleotide binding region [chemical binding]; other site 483219018954 SEC-C motif; Region: SEC-C; pfam02810 483219018955 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219018956 S-adenosylmethionine binding site [chemical binding]; other site 483219018957 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 483219018958 metal binding site [ion binding]; metal-binding site 483219018959 active site 483219018960 I-site; other site 483219018961 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 483219018962 Peptidase family M23; Region: Peptidase_M23; pfam01551 483219018963 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 483219018964 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 483219018965 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219018966 Walker A/P-loop; other site 483219018967 ATP binding site [chemical binding]; other site 483219018968 Q-loop/lid; other site 483219018969 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 483219018970 ABC transporter signature motif; other site 483219018971 Walker B; other site 483219018972 D-loop; other site 483219018973 H-loop/switch region; other site 483219018974 SNF2 Helicase protein; Region: DUF3670; pfam12419 483219018975 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 483219018976 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 483219018977 ATP binding site [chemical binding]; other site 483219018978 putative Mg++ binding site [ion binding]; other site 483219018979 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 483219018980 nucleotide binding region [chemical binding]; other site 483219018981 ATP-binding site [chemical binding]; other site 483219018982 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 483219018983 active site 483219018984 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 483219018985 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 483219018986 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 483219018987 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 483219018988 muropeptide transporter; Validated; Region: ampG; cl17669 483219018989 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 483219018990 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 483219018991 active site 483219018992 (T/H)XGH motif; other site 483219018993 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 483219018994 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 483219018995 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 483219018996 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 483219018997 catalytic site [active] 483219018998 active site 483219018999 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 483219019000 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 483219019001 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 483219019002 active site 483219019003 metal binding site [ion binding]; metal-binding site 483219019004 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 483219019005 Uncharacterized conserved protein [Function unknown]; Region: COG1434 483219019006 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 483219019007 putative active site [active] 483219019008 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 483219019009 ATP-NAD kinase; Region: NAD_kinase; pfam01513 483219019010 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219019011 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 483219019012 active site 483219019013 phosphorylation site [posttranslational modification] 483219019014 intermolecular recognition site; other site 483219019015 dimerization interface [polypeptide binding]; other site 483219019016 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219019017 Walker A motif; other site 483219019018 ATP binding site [chemical binding]; other site 483219019019 Walker B motif; other site 483219019020 arginine finger; other site 483219019021 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 483219019022 Response regulator receiver domain; Region: Response_reg; pfam00072 483219019023 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219019024 active site 483219019025 phosphorylation site [posttranslational modification] 483219019026 intermolecular recognition site; other site 483219019027 dimerization interface [polypeptide binding]; other site 483219019028 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219019029 dimer interface [polypeptide binding]; other site 483219019030 phosphorylation site [posttranslational modification] 483219019031 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219019032 ATP binding site [chemical binding]; other site 483219019033 G-X-G motif; other site 483219019034 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 483219019035 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 483219019036 metal binding site [ion binding]; metal-binding site 483219019037 active site 483219019038 I-site; other site 483219019039 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 483219019040 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 483219019041 Ligand binding site; other site 483219019042 Putative Catalytic site; other site 483219019043 DXD motif; other site 483219019044 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 483219019045 Methyltransferase domain; Region: Methyltransf_23; pfam13489 483219019046 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219019047 S-adenosylmethionine binding site [chemical binding]; other site 483219019048 Mannosyltransferase (PIG-V)); Region: Mannosyl_trans2; pfam04188 483219019049 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 483219019050 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 483219019051 substrate binding site [chemical binding]; other site 483219019052 oxyanion hole (OAH) forming residues; other site 483219019053 trimer interface [polypeptide binding]; other site 483219019054 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 483219019055 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 483219019056 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 483219019057 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 483219019058 dimer interface [polypeptide binding]; other site 483219019059 active site 483219019060 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 483219019061 substrate binding site [chemical binding]; other site 483219019062 active site 483219019063 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 483219019064 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 483219019065 active site 483219019066 catalytic site [active] 483219019067 Starch binding domain; Region: CBM_2; smart01065 483219019068 starch-binding site 1 [chemical binding]; other site 483219019069 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 483219019070 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 483219019071 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 483219019072 active site 483219019073 catalytic site [active] 483219019074 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 483219019075 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 483219019076 Walker A/P-loop; other site 483219019077 ATP binding site [chemical binding]; other site 483219019078 Q-loop/lid; other site 483219019079 ABC transporter signature motif; other site 483219019080 Walker B; other site 483219019081 D-loop; other site 483219019082 H-loop/switch region; other site 483219019083 TOBE domain; Region: TOBE_2; pfam08402 483219019084 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 483219019085 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 483219019086 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483219019087 dimer interface [polypeptide binding]; other site 483219019088 conserved gate region; other site 483219019089 putative PBP binding loops; other site 483219019090 ABC-ATPase subunit interface; other site 483219019091 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 483219019092 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483219019093 dimer interface [polypeptide binding]; other site 483219019094 conserved gate region; other site 483219019095 putative PBP binding loops; other site 483219019096 ABC-ATPase subunit interface; other site 483219019097 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 483219019098 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 483219019099 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 483219019100 NAD binding site [chemical binding]; other site 483219019101 catalytic Zn binding site [ion binding]; other site 483219019102 structural Zn binding site [ion binding]; other site 483219019103 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 483219019104 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 483219019105 catalytic residue [active] 483219019106 Thioredoxin; Region: Thioredoxin_4; cl17273 483219019107 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 483219019108 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 483219019109 aminoglycoside resistance protein; Provisional; Region: PRK13746 483219019110 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 483219019111 active site 483219019112 NTP binding site [chemical binding]; other site 483219019113 metal binding triad [ion binding]; metal-binding site 483219019114 antibiotic binding site [chemical binding]; other site 483219019115 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 483219019116 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 483219019117 Transcriptional regulator PadR-like family; Region: PadR; cl17335 483219019118 Predicted transcriptional regulators [Transcription]; Region: COG1695 483219019119 Uncharacterized conserved protein [Function unknown]; Region: COG3791 483219019120 PilZ domain; Region: PilZ; cl01260 483219019121 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 483219019122 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 483219019123 putative di-iron ligands [ion binding]; other site 483219019124 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 483219019125 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 483219019126 active site 483219019127 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 483219019128 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 483219019129 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 483219019130 Coenzyme A binding pocket [chemical binding]; other site 483219019131 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 483219019132 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 483219019133 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 483219019134 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 483219019135 putative sugar binding sites [chemical binding]; other site 483219019136 Q-X-W motif; other site 483219019137 Shewanella-like phosphatases, metallophosphatase domain; Region: MPP_Shelphs; cd07425 483219019138 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 483219019139 active site 483219019140 metal binding site [ion binding]; metal-binding site 483219019141 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 483219019142 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 483219019143 NAD(P) binding site [chemical binding]; other site 483219019144 active site 483219019145 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 483219019146 glutathionine S-transferase; Provisional; Region: PRK10542 483219019147 C-terminal domain interface [polypeptide binding]; other site 483219019148 GSH binding site (G-site) [chemical binding]; other site 483219019149 dimer interface [polypeptide binding]; other site 483219019150 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 483219019151 dimer interface [polypeptide binding]; other site 483219019152 N-terminal domain interface [polypeptide binding]; other site 483219019153 substrate binding pocket (H-site) [chemical binding]; other site 483219019154 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 483219019155 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 483219019156 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 483219019157 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 483219019158 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 483219019159 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 483219019160 S-adenosylmethionine binding site [chemical binding]; other site 483219019161 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 483219019162 Walker A motif; other site 483219019163 ATP binding site [chemical binding]; other site 483219019164 Family description; Region: UvrD_C_2; pfam13538 483219019165 PAS fold; Region: PAS_4; pfam08448 483219019166 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 483219019167 putative active site [active] 483219019168 heme pocket [chemical binding]; other site 483219019169 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 483219019170 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 483219019171 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219019172 dimer interface [polypeptide binding]; other site 483219019173 phosphorylation site [posttranslational modification] 483219019174 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 483219019175 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219019176 ATP binding site [chemical binding]; other site 483219019177 Mg2+ binding site [ion binding]; other site 483219019178 G-X-G motif; other site 483219019179 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 483219019180 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 483219019181 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 483219019182 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 483219019183 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 483219019184 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 483219019185 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 483219019186 tetramer (dimer of dimers) interface [polypeptide binding]; other site 483219019187 active site 483219019188 dimer interface [polypeptide binding]; other site 483219019189 Beta-propeller repeat; Region: SBBP; pfam06739 483219019190 Beta-propeller repeat; Region: SBBP; pfam06739 483219019191 Transcriptional regulator [Transcription]; Region: LysR; COG0583 483219019192 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 483219019193 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 483219019194 dimerization interface [polypeptide binding]; other site 483219019195 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 483219019196 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 483219019197 ArsC family; Region: ArsC; pfam03960 483219019198 putative ArsC-like catalytic residues; other site 483219019199 putative TRX-like catalytic residues [active] 483219019200 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 483219019201 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219019202 TPR motif; other site 483219019203 binding surface 483219019204 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219019205 binding surface 483219019206 TPR motif; other site 483219019207 SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829 483219019208 active site 483219019209 catalytic triad [active] 483219019210 oxyanion hole [active] 483219019211 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 483219019212 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 483219019213 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219019214 Walker A/P-loop; other site 483219019215 ATP binding site [chemical binding]; other site 483219019216 Q-loop/lid; other site 483219019217 ABC transporter signature motif; other site 483219019218 Walker B; other site 483219019219 D-loop; other site 483219019220 H-loop/switch region; other site 483219019221 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 483219019222 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 483219019223 substrate binding pocket [chemical binding]; other site 483219019224 membrane-bound complex binding site; other site 483219019225 hinge residues; other site 483219019226 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 483219019227 dimer interface [polypeptide binding]; other site 483219019228 conserved gate region; other site 483219019229 ABC-ATPase subunit interface; other site 483219019230 Response regulator receiver domain; Region: Response_reg; pfam00072 483219019231 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219019232 active site 483219019233 phosphorylation site [posttranslational modification] 483219019234 intermolecular recognition site; other site 483219019235 dimerization interface [polypeptide binding]; other site 483219019236 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 483219019237 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 483219019238 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 483219019239 DNA binding residues [nucleotide binding] 483219019240 CHAT domain; Region: CHAT; cl17868 483219019241 AAA domain; Region: AAA_11; pfam13086 483219019242 Part of AAA domain; Region: AAA_19; pfam13245 483219019243 AAA domain; Region: AAA_30; pfam13604 483219019244 AAA domain; Region: AAA_12; pfam13087 483219019245 AAA ATPase domain; Region: AAA_16; pfam13191 483219019246 Family description; Region: UvrD_C_2; pfam13538 483219019247 uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904 483219019248 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 483219019249 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 483219019250 Protein of unknown function, DUF399; Region: DUF399; pfam04187 483219019251 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 483219019252 RNA binding surface [nucleotide binding]; other site 483219019253 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 483219019254 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 483219019255 active site 483219019256 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 483219019257 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219019258 active site 483219019259 ATP binding site [chemical binding]; other site 483219019260 substrate binding site [chemical binding]; other site 483219019261 activation loop (A-loop); other site 483219019262 Beta-lactamase; Region: Beta-lactamase; pfam00144 483219019263 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 483219019264 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 483219019265 Beta-lactamase; Region: Beta-lactamase; pfam00144 483219019266 DoxX-like family; Region: DoxX_2; pfam13564 483219019267 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 483219019268 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 483219019269 lipase chaperone; Provisional; Region: PRK01294 483219019270 Proteobacterial lipase chaperone protein; Region: Lipase_chap; pfam03280 483219019271 Uncharacterized conserved protein [Function unknown]; Region: COG3791 483219019272 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 483219019273 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 483219019274 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 483219019275 putative dimer interface [polypeptide binding]; other site 483219019276 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 483219019277 catalytic core [active] 483219019278 Hemerythrin-like domain; Region: Hr-like; cd12108 483219019279 Fe binding site [ion binding]; other site 483219019280 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 483219019281 HemN C-terminal domain; Region: HemN_C; pfam06969 483219019282 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 483219019283 4Fe-4S binding domain; Region: Fer4_5; pfam12801 483219019284 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 483219019285 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 483219019286 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 483219019287 putative bifunctional cbb3-type cytochrome c oxidase subunit I/II; Provisional; Region: PRK14485 483219019288 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 483219019289 Low-spin heme binding site [chemical binding]; other site 483219019290 Putative water exit pathway; other site 483219019291 Binuclear center (active site) [active] 483219019292 Putative proton exit pathway; other site 483219019293 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 483219019294 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 483219019295 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 483219019296 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 483219019297 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 483219019298 Family description; Region: DsbD_2; pfam13386 483219019299 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 483219019300 Predicted membrane protein [Function unknown]; Region: COG4325 483219019301 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 483219019302 TrkA-N domain; Region: TrkA_N; pfam02254 483219019303 TrkA-C domain; Region: TrkA_C; pfam02080 483219019304 Cation transport protein; Region: TrkH; cl17365 483219019305 Cation transport protein; Region: TrkH; cl17365 483219019306 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 483219019307 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 483219019308 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 483219019309 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 483219019310 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 483219019311 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 483219019312 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 483219019313 enoyl-CoA hydratase; Provisional; Region: PRK06563 483219019314 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 483219019315 substrate binding site [chemical binding]; other site 483219019316 oxyanion hole (OAH) forming residues; other site 483219019317 trimer interface [polypeptide binding]; other site 483219019318 SEC-C motif; Region: SEC-C; pfam02810 483219019319 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 483219019320 putative oxidoreductase; Provisional; Region: PRK11579 483219019321 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 483219019322 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 483219019323 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 483219019324 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 483219019325 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 483219019326 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 483219019327 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 483219019328 molybdopterin cofactor binding site; other site 483219019329 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 483219019330 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 483219019331 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 483219019332 heme-binding residues [chemical binding]; other site 483219019333 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 483219019334 Cytochrome c; Region: Cytochrom_C; pfam00034 483219019335 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 483219019336 Predicted periplasmic lipoprotein (DUF2279); Region: DUF2279; cl11574 483219019337 Acyltransferase family; Region: Acyl_transf_3; pfam01757 483219019338 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 483219019339 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 483219019340 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 483219019341 putative RNA binding site [nucleotide binding]; other site 483219019342 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219019343 S-adenosylmethionine binding site [chemical binding]; other site 483219019344 Flagellin N-methylase; Region: FliB; pfam03692 483219019345 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 483219019346 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 483219019347 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 483219019348 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 483219019349 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 483219019350 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 483219019351 catalytic triad [active] 483219019352 conserved cis-peptide bond; other site 483219019353 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 483219019354 active site 483219019355 TonB C terminal; Region: TonB_2; pfam13103 483219019356 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 483219019357 dimer interface [polypeptide binding]; other site 483219019358 substrate binding site [chemical binding]; other site 483219019359 metal binding sites [ion binding]; metal-binding site 483219019360 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 483219019361 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 483219019362 putative acyl-acceptor binding pocket; other site 483219019363 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 483219019364 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 483219019365 motif 1; other site 483219019366 dimer interface [polypeptide binding]; other site 483219019367 active site 483219019368 motif 2; other site 483219019369 motif 3; other site 483219019370 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 483219019371 Zn binding site [ion binding]; other site 483219019372 Fn3 associated; Region: Fn3_assoc; pfam13287 483219019373 CotH protein; Region: CotH; pfam08757 483219019374 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 483219019375 Short C-terminal domain; Region: SHOCT; pfam09851 483219019376 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 483219019377 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 483219019378 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 483219019379 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 483219019380 Walker A/P-loop; other site 483219019381 ATP binding site [chemical binding]; other site 483219019382 Q-loop/lid; other site 483219019383 ABC transporter signature motif; other site 483219019384 Walker B; other site 483219019385 D-loop; other site 483219019386 H-loop/switch region; other site 483219019387 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 483219019388 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 483219019389 putative RNA ligase; Region: PHA02142 483219019390 RNA ligase; Region: RNA_ligase; pfam09414 483219019391 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 483219019392 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 483219019393 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 483219019394 phosphopeptide binding site; other site 483219019395 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 483219019396 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 483219019397 phosphopeptide binding site; other site 483219019398 TPR repeat; Region: TPR_11; pfam13414 483219019399 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219019400 TPR motif; other site 483219019401 binding surface 483219019402 Response regulator receiver domain; Region: Response_reg; pfam00072 483219019403 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219019404 active site 483219019405 phosphorylation site [posttranslational modification] 483219019406 intermolecular recognition site; other site 483219019407 dimerization interface [polypeptide binding]; other site 483219019408 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 483219019409 non-specific DNA binding site [nucleotide binding]; other site 483219019410 salt bridge; other site 483219019411 sequence-specific DNA binding site [nucleotide binding]; other site 483219019412 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 483219019413 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 483219019414 substrate binding site [chemical binding]; other site 483219019415 oxyanion hole (OAH) forming residues; other site 483219019416 trimer interface [polypeptide binding]; other site 483219019417 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 483219019418 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 483219019419 carboxyltransferase (CT) interaction site; other site 483219019420 biotinylation site [posttranslational modification]; other site 483219019421 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 483219019422 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 483219019423 ATP-grasp domain; Region: ATP-grasp_4; cl17255 483219019424 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 483219019425 cell division protein FtsZ; Validated; Region: PRK09330 483219019426 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 483219019427 nucleotide binding site [chemical binding]; other site 483219019428 SulA interaction site; other site 483219019429 cell division protein FtsZ, alphaProteobacterial C-terminal extension; Region: FtsZ_alphas_C; TIGR03483 483219019430 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 483219019431 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 483219019432 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 483219019433 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 483219019434 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 483219019435 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 483219019436 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 483219019437 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 483219019438 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 483219019439 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 483219019440 ligand binding site [chemical binding]; other site 483219019441 cell division protein FtsA; Region: ftsA; TIGR01174 483219019442 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 483219019443 nucleotide binding site [chemical binding]; other site 483219019444 Cell division protein FtsA; Region: FtsA; pfam14450 483219019445 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 483219019446 Cell division protein FtsQ; Region: FtsQ; pfam03799 483219019447 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 483219019448 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 483219019449 ATP-grasp domain; Region: ATP-grasp_4; cl17255 483219019450 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK14652 483219019451 FAD binding domain; Region: FAD_binding_4; pfam01565 483219019452 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 483219019453 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 483219019454 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 483219019455 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 483219019456 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 483219019457 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 483219019458 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 483219019459 active site 483219019460 homodimer interface [polypeptide binding]; other site 483219019461 cell division protein FtsW; Region: ftsW; TIGR02614 483219019462 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 483219019463 Putative NAD(P)-binding; Region: NAD_binding_7; cl17660 483219019464 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 483219019465 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 483219019466 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 483219019467 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 483219019468 Mg++ binding site [ion binding]; other site 483219019469 putative catalytic motif [active] 483219019470 putative substrate binding site [chemical binding]; other site 483219019471 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 483219019472 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 483219019473 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 483219019474 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 483219019475 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 483219019476 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 483219019477 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 483219019478 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 483219019479 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 483219019480 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 483219019481 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 483219019482 Cell division protein FtsL; Region: FtsL; pfam04999 483219019483 MraW methylase family; Region: Methyltransf_5; cl17771 483219019484 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 483219019485 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 483219019486 Cell division protein FtsL; Region: FtsL; pfam04999 483219019487 MraW methylase family; Region: Methyltransf_5; cl17771 483219019488 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 483219019489 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 483219019490 anti sigma factor interaction site; other site 483219019491 regulatory phosphorylation site [posttranslational modification]; other site 483219019492 cell division protein MraZ; Reviewed; Region: PRK00326 483219019493 MraZ protein; Region: MraZ; pfam02381 483219019494 MraZ protein; Region: MraZ; pfam02381 483219019495 PilZ domain; Region: PilZ; cl01260 483219019496 PilZ domain; Region: PilZ; pfam07238 483219019497 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 483219019498 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 483219019499 active site 483219019500 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 483219019501 dimerization interface [polypeptide binding]; other site 483219019502 putative DNA binding site [nucleotide binding]; other site 483219019503 putative Zn2+ binding site [ion binding]; other site 483219019504 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 483219019505 putative hydrophobic ligand binding site [chemical binding]; other site 483219019506 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219019507 Catalytic domain of Protein Kinases; Region: PKc; cd00180 483219019508 active site 483219019509 ATP binding site [chemical binding]; other site 483219019510 substrate binding site [chemical binding]; other site 483219019511 activation loop (A-loop); other site 483219019512 PEGA domain; Region: PEGA; pfam08308 483219019513 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 483219019514 Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cl17349 483219019515 active site 483219019516 Zn binding site [ion binding]; other site 483219019517 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 483219019518 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 483219019519 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 483219019520 putative active site [active] 483219019521 metal binding site [ion binding]; metal-binding site 483219019522 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 483219019523 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 483219019524 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 483219019525 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 483219019526 catalytic triad [active] 483219019527 Domain of unknown function DUF20; Region: UPF0118; pfam01594 483219019528 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 483219019529 transcription termination factor Rho; Provisional; Region: rho; PRK09376 483219019530 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 483219019531 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 483219019532 RNA binding site [nucleotide binding]; other site 483219019533 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 483219019534 multimer interface [polypeptide binding]; other site 483219019535 Walker A motif; other site 483219019536 ATP binding site [chemical binding]; other site 483219019537 Walker B motif; other site 483219019538 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 483219019539 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 483219019540 nucleotide binding pocket [chemical binding]; other site 483219019541 K-X-D-G motif; other site 483219019542 catalytic site [active] 483219019543 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 483219019544 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 483219019545 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 483219019546 Dimer interface [polypeptide binding]; other site 483219019547 BRCT sequence motif; other site 483219019548 Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254 483219019549 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 483219019550 homodimer interface [polypeptide binding]; other site 483219019551 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 483219019552 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 483219019553 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 483219019554 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 483219019555 IHF dimer interface [polypeptide binding]; other site 483219019556 IHF - DNA interface [nucleotide binding]; other site 483219019557 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 483219019558 FHIPEP family; Region: FHIPEP; pfam00771 483219019559 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 483219019560 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 483219019561 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 483219019562 Bacterial export proteins, family 3; Region: Bac_export_3; pfam01313 483219019563 FliP family; Region: FliP; cl00593 483219019564 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 483219019565 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 483219019566 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 483219019567 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 483219019568 PilZ domain; Region: PilZ; pfam07238 483219019569 Response regulator receiver domain; Region: Response_reg; pfam00072 483219019570 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219019571 active site 483219019572 phosphorylation site [posttranslational modification] 483219019573 intermolecular recognition site; other site 483219019574 dimerization interface [polypeptide binding]; other site 483219019575 Oxygen tolerance; Region: BatD; pfam13584 483219019576 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219019577 TPR repeat; Region: TPR_11; pfam13414 483219019578 binding surface 483219019579 TPR motif; other site 483219019580 von Willebrand factor type A domain; Region: VWA_2; pfam13519 483219019581 metal ion-dependent adhesion site (MIDAS); other site 483219019582 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 483219019583 metal ion-dependent adhesion site (MIDAS); other site 483219019584 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 483219019585 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 483219019586 metal ion-dependent adhesion site (MIDAS); other site 483219019587 MoxR-like ATPases [General function prediction only]; Region: COG0714 483219019588 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219019589 Walker A motif; other site 483219019590 ATP binding site [chemical binding]; other site 483219019591 Walker B motif; other site 483219019592 arginine finger; other site 483219019593 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 483219019594 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 483219019595 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 483219019596 nucleophilic elbow; other site 483219019597 catalytic triad; other site 483219019598 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 483219019599 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 483219019600 catalytic residues [active] 483219019601 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 483219019602 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 483219019603 phosphopeptide binding site; other site 483219019604 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 483219019605 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219019606 Walker A motif; other site 483219019607 ATP binding site [chemical binding]; other site 483219019608 Walker B motif; other site 483219019609 arginine finger; other site 483219019610 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 483219019611 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; pfam04115 483219019612 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 483219019613 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 483219019614 Domain of unknown function (DUF4401); Region: DUF4401; pfam14351 483219019615 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 483219019616 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 483219019617 heme binding pocket [chemical binding]; other site 483219019618 heme ligand [chemical binding]; other site 483219019619 potential frameshift: common BLAST hit: gi|108762746|ref|YP_633818.1| putative sigma-54 dependent transcriptional regulator 483219019620 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219019621 S-adenosylmethionine binding site [chemical binding]; other site 483219019622 FOG: CBS domain [General function prediction only]; Region: COG0517 483219019623 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 483219019624 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 483219019625 ZIP Zinc transporter; Region: Zip; pfam02535 483219019626 potential frameshift: common BLAST hit: gi|108758652|ref|YP_633821.1| putative lipoprotein 483219019627 uncharacterized proteobacterial lipoprotein; Region: lp_; TIGR02722 483219019628 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 483219019629 Mechanosensitive ion channel; Region: MS_channel; pfam00924 483219019630 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 483219019631 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219019632 active site 483219019633 phosphorylation site [posttranslational modification] 483219019634 intermolecular recognition site; other site 483219019635 dimerization interface [polypeptide binding]; other site 483219019636 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 483219019637 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 483219019638 heme-binding residues [chemical binding]; other site 483219019639 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 483219019640 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 483219019641 N-acetyl-D-glucosamine binding site [chemical binding]; other site 483219019642 catalytic residue [active] 483219019643 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 483219019644 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 483219019645 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 483219019646 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 483219019647 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 483219019648 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 483219019649 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 483219019650 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 483219019651 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 483219019652 active site 483219019653 substrate binding site [chemical binding]; other site 483219019654 Mg2+ binding site [ion binding]; other site 483219019655 Ycf46; Provisional; Region: ycf46; CHL00195 483219019656 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219019657 Walker A motif; other site 483219019658 ATP binding site [chemical binding]; other site 483219019659 Walker B motif; other site 483219019660 arginine finger; other site 483219019661 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 483219019662 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 483219019663 active site 483219019664 ATP binding site [chemical binding]; other site 483219019665 substrate binding site [chemical binding]; other site 483219019666 activation loop (A-loop); other site 483219019667 PEGA domain; Region: PEGA; pfam08308 483219019668 PEGA domain; Region: PEGA; pfam08308 483219019669 FtsX-like permease family; Region: FtsX; pfam02687 483219019670 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 483219019671 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 483219019672 Walker A/P-loop; other site 483219019673 ATP binding site [chemical binding]; other site 483219019674 Q-loop/lid; other site 483219019675 ABC transporter signature motif; other site 483219019676 Walker B; other site 483219019677 D-loop; other site 483219019678 H-loop/switch region; other site 483219019679 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 483219019680 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 483219019681 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 483219019682 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 483219019683 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219019684 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219019685 dimer interface [polypeptide binding]; other site 483219019686 phosphorylation site [posttranslational modification] 483219019687 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219019688 ATP binding site [chemical binding]; other site 483219019689 Mg2+ binding site [ion binding]; other site 483219019690 G-X-G motif; other site 483219019691 N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228 483219019692 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 483219019693 active site 483219019694 putative substrate binding pocket [chemical binding]; other site 483219019695 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 483219019696 active site 483219019697 catalytic motif [active] 483219019698 Zn binding site [ion binding]; other site 483219019699 PilZ domain; Region: PilZ; cl01260 483219019700 SET domain; Region: SET; pfam00856 483219019701 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 483219019702 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 483219019703 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 483219019704 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 483219019705 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 483219019706 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 483219019707 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 483219019708 ligand binding site [chemical binding]; other site 483219019709 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 483219019710 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 483219019711 Walker A/P-loop; other site 483219019712 ATP binding site [chemical binding]; other site 483219019713 Q-loop/lid; other site 483219019714 ABC transporter signature motif; other site 483219019715 Walker B; other site 483219019716 D-loop; other site 483219019717 H-loop/switch region; other site 483219019718 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 483219019719 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 483219019720 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 483219019721 TM-ABC transporter signature motif; other site 483219019722 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 483219019723 TM-ABC transporter signature motif; other site 483219019724 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219019725 intermolecular recognition site; other site 483219019726 active site 483219019727 dimerization interface [polypeptide binding]; other site 483219019728 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 483219019729 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219019730 ATP binding site [chemical binding]; other site 483219019731 Mg2+ binding site [ion binding]; other site 483219019732 G-X-G motif; other site 483219019733 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 483219019734 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 483219019735 active site 483219019736 substrate binding site [chemical binding]; other site 483219019737 metal binding site [ion binding]; metal-binding site 483219019738 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 483219019739 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 483219019740 intersubunit interface [polypeptide binding]; other site 483219019741 active site 483219019742 catalytic residue [active] 483219019743 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 483219019744 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 483219019745 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 483219019746 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 483219019747 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 483219019748 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 483219019749 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 483219019750 TIGR02300 family protein; Region: FYDLN_acid 483219019751 Cna protein B-type domain; Region: Cna_B_2; pfam13715 483219019752 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 483219019753 Putative zinc ribbon domain; Region: DUF164; pfam02591 483219019754 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 483219019755 RNA/DNA hybrid binding site [nucleotide binding]; other site 483219019756 active site 483219019757 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 483219019758 Mrr N-terminal domain; Region: Mrr_N; pfam14338 483219019759 Restriction endonuclease; Region: Mrr_cat; pfam04471 483219019760 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 483219019761 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 483219019762 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 483219019763 HsdM N-terminal domain; Region: HsdM_N; pfam12161 483219019764 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 483219019765 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219019766 S-adenosylmethionine binding site [chemical binding]; other site 483219019767 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 483219019768 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 483219019769 Protein of unknown function DUF91; Region: DUF91; cl00709 483219019770 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 483219019771 ATP binding site [chemical binding]; other site 483219019772 putative Mg++ binding site [ion binding]; other site 483219019773 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 483219019774 nucleotide binding region [chemical binding]; other site 483219019775 ATP-binding site [chemical binding]; other site 483219019776 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 483219019777 DUSAM domain; Region: TIGR02267 483219019778 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 483219019779 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 483219019780 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 483219019781 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 483219019782 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 483219019783 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 483219019784 GTP binding site [chemical binding]; other site 483219019785 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 483219019786 Zn binding site [ion binding]; other site 483219019787 PEGA domain; Region: PEGA; pfam08308 483219019788 Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex; Region: CESA_CaSu_A2; cd06437 483219019789 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 483219019790 DXD motif; other site 483219019791 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 483219019792 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 483219019793 ATP-grasp domain; Region: ATP-grasp_4; cl17255 483219019794 PEGA domain; Region: PEGA; pfam08308 483219019795 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 483219019796 C-terminal peptidase (prc); Region: prc; TIGR00225 483219019797 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 483219019798 protein binding site [polypeptide binding]; other site 483219019799 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 483219019800 Catalytic dyad [active] 483219019801 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 483219019802 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 483219019803 catalytic site [active] 483219019804 Peptidase family M23; Region: Peptidase_M23; pfam01551 483219019805 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 483219019806 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 483219019807 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 483219019808 Walker A/P-loop; other site 483219019809 ATP binding site [chemical binding]; other site 483219019810 Q-loop/lid; other site 483219019811 ABC transporter signature motif; other site 483219019812 Walker B; other site 483219019813 D-loop; other site 483219019814 H-loop/switch region; other site 483219019815 Kua-ubiquitin conjugating enzyme hybrid localisation domain; Region: Kua-UEV1_localn; pfam10520 483219019816 glutamate racemase; Provisional; Region: PRK00865 483219019817 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 483219019818 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 483219019819 TolR protein; Region: tolR; TIGR02801 483219019820 TolA protein; Region: tolA_full; TIGR02794 483219019821 TonB C terminal; Region: TonB_2; pfam13103 483219019822 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 483219019823 TolB amino-terminal domain; Region: TolB_N; pfam04052 483219019824 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 483219019825 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 483219019826 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 483219019827 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 483219019828 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 483219019829 potential frameshift: common BLAST hit: gi|108759751|ref|YP_633895.1| isopenicillin N epimerase 483219019830 exopolyphosphatase; Region: exo_poly_only; TIGR03706 483219019831 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 483219019832 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 483219019833 Major Facilitator Superfamily; Region: MFS_1; pfam07690 483219019834 putative substrate translocation pore; other site 483219019835 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 483219019836 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Region: LPLAT_AAK14816-like; cd07992 483219019837 putative acyl-acceptor binding pocket; other site 483219019838 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 483219019839 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 483219019840 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 483219019841 Surface antigen; Region: Bac_surface_Ag; pfam01103 483219019842 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 483219019843 Family of unknown function (DUF490); Region: DUF490; pfam04357 483219019844 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 483219019845 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219019846 Walker A motif; other site 483219019847 ATP binding site [chemical binding]; other site 483219019848 Walker B motif; other site 483219019849 arginine finger; other site 483219019850 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219019851 binding surface 483219019852 TPR motif; other site 483219019853 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 483219019854 TPR motif; other site 483219019855 binding surface 483219019856 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 483219019857 TPR motif; other site 483219019858 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 483219019859 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 483219019860 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 483219019861 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 483219019862 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 483219019863 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 483219019864 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 483219019865 carboxyltransferase (CT) interaction site; other site 483219019866 biotinylation site [posttranslational modification]; other site 483219019867 elongation factor P; Validated; Region: PRK00529 483219019868 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 483219019869 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 483219019870 RNA binding site [nucleotide binding]; other site 483219019871 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 483219019872 RNA binding site [nucleotide binding]; other site 483219019873 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 483219019874 AMIN domain; Region: AMIN; pfam11741 483219019875 AMIN domain; Region: AMIN; pfam11741 483219019876 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 483219019877 Secretin and TonB N terminus short domain; Region: STN; smart00965 483219019878 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 483219019879 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 483219019880 Pilus assembly protein, PilP; Region: PilP; pfam04351 483219019881 Pilus assembly protein, PilO; Region: PilO; pfam04350 483219019882 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 483219019883 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 483219019884 Competence protein A; Region: Competence_A; pfam11104 483219019885 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 483219019886 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 483219019887 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219019888 active site 483219019889 phosphorylation site [posttranslational modification] 483219019890 intermolecular recognition site; other site 483219019891 dimerization interface [polypeptide binding]; other site 483219019892 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219019893 Walker A motif; other site 483219019894 ATP binding site [chemical binding]; other site 483219019895 Walker B motif; other site 483219019896 arginine finger; other site 483219019897 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 483219019898 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219019899 dimer interface [polypeptide binding]; other site 483219019900 phosphorylation site [posttranslational modification] 483219019901 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219019902 ATP binding site [chemical binding]; other site 483219019903 Mg2+ binding site [ion binding]; other site 483219019904 G-X-G motif; other site 483219019905 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 483219019906 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 483219019907 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 483219019908 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 483219019909 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 483219019910 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 483219019911 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 483219019912 Walker A/P-loop; other site 483219019913 ATP binding site [chemical binding]; other site 483219019914 Q-loop/lid; other site 483219019915 ABC transporter signature motif; other site 483219019916 Walker B; other site 483219019917 D-loop; other site 483219019918 H-loop/switch region; other site 483219019919 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 483219019920 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 483219019921 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 483219019922 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 483219019923 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219019924 active site 483219019925 phosphorylation site [posttranslational modification] 483219019926 intermolecular recognition site; other site 483219019927 dimerization interface [polypeptide binding]; other site 483219019928 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219019929 Walker A motif; other site 483219019930 ATP binding site [chemical binding]; other site 483219019931 Walker B motif; other site 483219019932 arginine finger; other site 483219019933 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 483219019934 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 483219019935 PAS domain; Region: PAS; smart00091 483219019936 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 483219019937 phosphorylation site [posttranslational modification] 483219019938 dimer interface [polypeptide binding]; other site 483219019939 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 483219019940 ATP binding site [chemical binding]; other site 483219019941 Mg2+ binding site [ion binding]; other site 483219019942 G-X-G motif; other site 483219019943 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 483219019944 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 483219019945 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 483219019946 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 483219019947 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 483219019948 Walker A motif; other site 483219019949 ATP binding site [chemical binding]; other site 483219019950 Walker B motif; other site 483219019951 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 483219019952 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 483219019953 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 483219019954 Walker A motif; other site 483219019955 ATP binding site [chemical binding]; other site 483219019956 Walker B motif; other site 483219019957 riboflavin kinase/FMN adenylyltransferase; Region: ribF; TIGR00083 483219019958 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 483219019959 active site 483219019960 Riboflavin kinase; Region: Flavokinase; pfam01687 483219019961 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 483219019962 S-adenosylmethionine binding site [chemical binding]; other site 483219019963 Response regulator receiver domain; Region: Response_reg; pfam00072 483219019964 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 483219019965 active site 483219019966 phosphorylation site [posttranslational modification] 483219019967 intermolecular recognition site; other site 483219019968 dimerization interface [polypeptide binding]; other site 483219019969 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 483219019970 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 483219019971 metal binding site [ion binding]; metal-binding site 483219019972 active site 483219019973 I-site; other site 483219019974 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 483219019975 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 483219019976 active site 483219019977 catalytic site [active] 483219019978 substrate binding site [chemical binding]; other site 483219019979 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 483219019980 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 483219019981 HAMP domain; Region: HAMP; pfam00672 483219019982 HEAT repeats; Region: HEAT_2; pfam13646 483219019983 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 483219019984 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 483219019985 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 483219019986 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 483219019987 transposase/IS protein; Provisional; Region: PRK09183 483219019988 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219019989 Walker A motif; other site 483219019990 ATP binding site [chemical binding]; other site 483219019991 Walker B motif; other site 483219019992 arginine finger; other site 483219019993 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 483219019994 Integrase core domain; Region: rve; pfam00665 483219019995 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 483219019996 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 483219019997 catalytic residues [active] 483219019998 catalytic nucleophile [active] 483219019999 Presynaptic Site I dimer interface [polypeptide binding]; other site 483219020000 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 483219020001 Synaptic Flat tetramer interface [polypeptide binding]; other site 483219020002 Synaptic Site I dimer interface [polypeptide binding]; other site 483219020003 DNA binding site [nucleotide binding] 483219020004 Recombinase; Region: Recombinase; pfam07508 483219020005 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 483219020006 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 483219020007 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 483219020008 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 483219020009 ATP binding site [chemical binding]; other site 483219020010 putative Mg++ binding site [ion binding]; other site 483219020011 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 483219020012 nucleotide binding region [chemical binding]; other site 483219020013 ATP-binding site [chemical binding]; other site 483219020014 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 483219020015 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 483219020016 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 483219020017 active site 483219020018 catalytic site [active] 483219020019 substrate binding site [chemical binding]; other site 483219020020 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 483219020021 active site 483219020022 DNA binding site [nucleotide binding] 483219020023 Int/Topo IB signature motif; other site 483219020024 large terminase protein; Provisional; Region: 17; PHA02533 483219020025 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 483219020026 Phage-related protein [Function unknown]; Region: COG4695; cl01923 483219020027 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 483219020028 Phage capsid family; Region: Phage_capsid; pfam05065 483219020029 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 483219020030 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 483219020031 Walker A motif; other site 483219020032 ATP binding site [chemical binding]; other site 483219020033 Walker B motif; other site 483219020034 Winged helix-turn helix; Region: HTH_29; pfam13551 483219020035 Homeodomain-like domain; Region: HTH_32; pfam13565 483219020036 Integrase core domain; Region: rve; pfam00665 483219020037 P63C domain; Region: P63C; pfam10546 483219020038 AAA domain; Region: AAA_11; pfam13086 483219020039 Part of AAA domain; Region: AAA_19; pfam13245 483219020040 AAA domain; Region: AAA_12; pfam13087 483219020041 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar5; cd09133 483219020042 PLD-like domain; Region: PLDc_2; pfam13091 483219020043 putative active site [active] 483219020044 putative catalytic site [active] 483219020045 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar5; cd09133 483219020046 PLD-like domain; Region: PLDc_2; pfam13091 483219020047 putative active site [active] 483219020048 putative catalytic site [active] 483219020049 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 483219020050 Virulence protein [General function prediction only]; Region: COG3943 483219020051 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 483219020052 Pirin; Region: Pirin; pfam02678 483219020053 Pirin-related protein [General function prediction only]; Region: COG1741 483219020054 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 483219020055 A new structural DNA glycosylase; Region: AlkD_like; cd06561 483219020056 active site 483219020057 putative transposase OrfB; Reviewed; Region: PHA02517 483219020058 Homeodomain-like domain; Region: HTH_32; pfam13565 483219020059 Integrase core domain; Region: rve; pfam00665 483219020060 Integrase core domain; Region: rve_3; pfam13683 483219020061 Transposase; Region: HTH_Tnp_1; cl17663 483219020062 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 483219020063 Integrase core domain; Region: rve; pfam00665