-- dump date 20140619_162102 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1278073000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1278073000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1278073000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073000004 Walker A motif; other site 1278073000005 ATP binding site [chemical binding]; other site 1278073000006 Walker B motif; other site 1278073000007 arginine finger; other site 1278073000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1278073000009 DnaA box-binding interface [nucleotide binding]; other site 1278073000010 Lipoprotein amino terminal region; Region: Vitellogenin_N; pfam01347 1278073000011 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 1278073000012 B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; Region: BBOX; cl00034 1278073000013 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1278073000014 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1278073000015 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1278073000016 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1278073000017 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1278073000018 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1278073000019 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1278073000020 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1278073000021 putative active site [active] 1278073000022 putative metal binding site [ion binding]; other site 1278073000023 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1278073000024 H+ Antiporter protein; Region: 2A0121; TIGR00900 1278073000025 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1278073000026 putative substrate translocation pore; other site 1278073000027 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1278073000028 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1278073000029 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1278073000030 putative active site [active] 1278073000031 putative metal binding site [ion binding]; other site 1278073000032 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1278073000033 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1278073000034 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 1278073000035 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1278073000036 glutathione synthetase; Provisional; Region: PRK05246 1278073000037 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1278073000038 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1278073000039 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1278073000040 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073000041 active site 1278073000042 ATP binding site [chemical binding]; other site 1278073000043 substrate binding site [chemical binding]; other site 1278073000044 activation loop (A-loop); other site 1278073000045 Tetratricopeptide repeat; Region: TPR_2; pfam07719 1278073000046 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1278073000047 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 1278073000048 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1278073000049 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073000050 active site 1278073000051 ATP binding site [chemical binding]; other site 1278073000052 substrate binding site [chemical binding]; other site 1278073000053 activation loop (A-loop); other site 1278073000054 PEGA domain; Region: PEGA; pfam08308 1278073000055 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1278073000056 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1278073000057 non-specific DNA binding site [nucleotide binding]; other site 1278073000058 salt bridge; other site 1278073000059 sequence-specific DNA binding site [nucleotide binding]; other site 1278073000060 ribonuclease R; Region: RNase_R; TIGR02063 1278073000061 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1278073000062 RNB domain; Region: RNB; pfam00773 1278073000063 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1278073000064 RNA binding site [nucleotide binding]; other site 1278073000065 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1278073000066 active site 1278073000067 Flagellin N-methylase; Region: FliB; pfam03692 1278073000068 NYN domain; Region: NYN; pfam01936 1278073000069 putative metal binding site [ion binding]; other site 1278073000070 Uncharacterized conserved protein [Function unknown]; Region: COG1432 1278073000071 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 1278073000072 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1278073000073 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1278073000074 intersubunit interface [polypeptide binding]; other site 1278073000075 active site 1278073000076 zinc binding site [ion binding]; other site 1278073000077 Na+ binding site [ion binding]; other site 1278073000078 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1278073000079 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1278073000080 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1278073000081 NMT1-like family; Region: NMT1_2; pfam13379 1278073000082 substrate binding pocket [chemical binding]; other site 1278073000083 membrane-bound complex binding site; other site 1278073000084 hinge residues; other site 1278073000085 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1278073000086 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1278073000087 dimer interface [polypeptide binding]; other site 1278073000088 conserved gate region; other site 1278073000089 putative PBP binding loops; other site 1278073000090 ABC-ATPase subunit interface; other site 1278073000091 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1278073000092 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1278073000093 Walker A/P-loop; other site 1278073000094 ATP binding site [chemical binding]; other site 1278073000095 Q-loop/lid; other site 1278073000096 ABC transporter signature motif; other site 1278073000097 Walker B; other site 1278073000098 D-loop; other site 1278073000099 H-loop/switch region; other site 1278073000100 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073000101 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073000102 active site 1278073000103 ATP binding site [chemical binding]; other site 1278073000104 substrate binding site [chemical binding]; other site 1278073000105 activation loop (A-loop); other site 1278073000106 PEGA domain; Region: PEGA; pfam08308 1278073000107 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1278073000108 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1278073000109 TPR motif; other site 1278073000110 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1278073000111 Glucose dehydrogenase; Region: glucose_DH; cd08230 1278073000112 NADP binding site [chemical binding]; other site 1278073000113 catalytic Zn binding site [ion binding]; other site 1278073000114 structural Zn binding site [ion binding]; other site 1278073000115 dimer interface [polypeptide binding]; other site 1278073000116 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1278073000117 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1278073000118 Major royal jelly protein; Region: MRJP; pfam03022 1278073000119 Uncharacterized conserved protein [Function unknown]; Region: COG4850 1278073000120 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 1278073000121 polyphosphate kinase; Provisional; Region: PRK05443 1278073000122 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1278073000123 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1278073000124 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1278073000125 putative domain interface [polypeptide binding]; other site 1278073000126 putative active site [active] 1278073000127 catalytic site [active] 1278073000128 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1278073000129 putative domain interface [polypeptide binding]; other site 1278073000130 putative active site [active] 1278073000131 catalytic site [active] 1278073000132 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 1278073000133 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1278073000134 PAS domain; Region: PAS_9; pfam13426 1278073000135 putative active site [active] 1278073000136 heme pocket [chemical binding]; other site 1278073000137 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1278073000138 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1278073000139 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1278073000140 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073000141 ATP binding site [chemical binding]; other site 1278073000142 Mg2+ binding site [ion binding]; other site 1278073000143 G-X-G motif; other site 1278073000144 Cupin domain; Region: Cupin_2; cl17218 1278073000145 Myxococcus xanthus paralogous domain TIGR02266; Region: gmx_TIGR02266 1278073000146 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1278073000147 hypothetical protein; Reviewed; Region: PRK09588 1278073000148 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1278073000149 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073000150 S-adenosylmethionine binding site [chemical binding]; other site 1278073000151 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1278073000152 RNA polymerase sigma-70 factor, Myxococcales family 1; Region: Sig-70_gmx1; TIGR03001 1278073000153 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1278073000154 DNA binding residues [nucleotide binding] 1278073000155 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 1278073000156 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1278073000157 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073000158 active site 1278073000159 ATP binding site [chemical binding]; other site 1278073000160 substrate binding site [chemical binding]; other site 1278073000161 activation loop (A-loop); other site 1278073000162 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 1278073000163 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073000164 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073000165 active site 1278073000166 ATP binding site [chemical binding]; other site 1278073000167 substrate binding site [chemical binding]; other site 1278073000168 activation loop (A-loop); other site 1278073000169 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 1278073000170 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1278073000171 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1278073000172 CoenzymeA binding site [chemical binding]; other site 1278073000173 subunit interaction site [polypeptide binding]; other site 1278073000174 PHB binding site; other site 1278073000175 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1278073000176 CoenzymeA binding site [chemical binding]; other site 1278073000177 subunit interaction site [polypeptide binding]; other site 1278073000178 PHB binding site; other site 1278073000179 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 1278073000180 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1278073000181 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1278073000182 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1278073000183 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1278073000184 Amidohydrolase; Region: Amidohydro_4; pfam13147 1278073000185 active site 1278073000186 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1278073000187 Deoxyhypusine synthase; Region: DS; cl00826 1278073000188 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1278073000189 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1278073000190 Predicted lipoprotein of unknown function (DUF2380); Region: DUF2380; pfam09533 1278073000191 Protein of unknown function (Gmx_para_CXXCG); Region: Gmx_para_CXXCG; cl15282 1278073000192 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 1278073000193 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1278073000194 NAD(P) binding site [chemical binding]; other site 1278073000195 substrate binding site [chemical binding]; other site 1278073000196 homotetramer interface [polypeptide binding]; other site 1278073000197 active site 1278073000198 homodimer interface [polypeptide binding]; other site 1278073000199 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1278073000200 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1278073000201 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 1278073000202 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 1278073000203 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1278073000204 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1278073000205 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1278073000206 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1278073000207 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1278073000208 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1278073000209 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1278073000210 carboxyltransferase (CT) interaction site; other site 1278073000211 biotinylation site [posttranslational modification]; other site 1278073000212 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1278073000213 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1278073000214 putative substrate translocation pore; other site 1278073000215 Domain of unknown function DUF59; Region: DUF59; cl00941 1278073000216 Amidohydrolase; Region: Amidohydro_2; pfam04909 1278073000217 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1278073000218 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1278073000219 putative active site [active] 1278073000220 heme pocket [chemical binding]; other site 1278073000221 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1278073000222 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1278073000223 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073000224 putative active site [active] 1278073000225 heme pocket [chemical binding]; other site 1278073000226 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073000227 dimer interface [polypeptide binding]; other site 1278073000228 phosphorylation site [posttranslational modification] 1278073000229 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073000230 ATP binding site [chemical binding]; other site 1278073000231 Mg2+ binding site [ion binding]; other site 1278073000232 G-X-G motif; other site 1278073000233 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1278073000234 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073000235 active site 1278073000236 phosphorylation site [posttranslational modification] 1278073000237 intermolecular recognition site; other site 1278073000238 dimerization interface [polypeptide binding]; other site 1278073000239 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1278073000240 PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815 1278073000241 PA/protease or protease-like domain interface [polypeptide binding]; other site 1278073000242 M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883 1278073000243 Peptidase family M28; Region: Peptidase_M28; pfam04389 1278073000244 metal binding site [ion binding]; metal-binding site 1278073000245 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1278073000246 cyclase homology domain; Region: CHD; cd07302 1278073000247 nucleotidyl binding site; other site 1278073000248 metal binding site [ion binding]; metal-binding site 1278073000249 dimer interface [polypeptide binding]; other site 1278073000250 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1278073000251 putative substrate translocation pore; other site 1278073000252 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1278073000253 FG-GAP repeat; Region: FG-GAP; pfam01839 1278073000254 Family description; Region: VCBS; pfam13517 1278073000255 Family description; Region: VCBS; pfam13517 1278073000256 Family description; Region: VCBS; pfam13517 1278073000257 Family description; Region: VCBS; pfam13517 1278073000258 Lysyl oxidase; Region: Lysyl_oxidase; pfam01186 1278073000259 FG-GAP repeat; Region: FG-GAP; pfam01839 1278073000260 Family description; Region: VCBS; pfam13517 1278073000261 Family description; Region: VCBS; pfam13517 1278073000262 Family description; Region: VCBS; pfam13517 1278073000263 Family description; Region: VCBS; pfam13517 1278073000264 Family description; Region: VCBS; pfam13517 1278073000265 Lysyl oxidase; Region: Lysyl_oxidase; pfam01186 1278073000266 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1278073000267 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1278073000268 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1278073000269 catalytic residue [active] 1278073000270 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1278073000271 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1278073000272 FtsX-like permease family; Region: FtsX; pfam02687 1278073000273 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1278073000274 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1278073000275 FtsX-like permease family; Region: FtsX; pfam02687 1278073000276 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1278073000277 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1278073000278 Coenzyme A binding pocket [chemical binding]; other site 1278073000279 Protein of unknown function (DUF770); Region: DUF770; cl01402 1278073000280 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 1278073000281 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1278073000282 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1278073000283 tetrameric interface [polypeptide binding]; other site 1278073000284 NAD binding site [chemical binding]; other site 1278073000285 catalytic residues [active] 1278073000286 hypothetical protein; Validated; Region: PRK07198 1278073000287 GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471 1278073000288 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1278073000289 dimerization interface [polypeptide binding]; other site 1278073000290 active site 1278073000291 Protein of unknown function (DUF1688); Region: DUF1688; pfam07958 1278073000292 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1278073000293 active site 1278073000294 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1278073000295 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 1278073000296 Stigma-specific protein, Stig1; Region: Stig1; pfam04885 1278073000297 Calcium-binding EGF domain; Region: EGF_CA; pfam07645 1278073000298 Ca2+ binding site [ion binding]; other site 1278073000299 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1278073000300 Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; Region: EGF_CA; cd00054 1278073000301 Ca2+ binding site [ion binding]; other site 1278073000302 Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; Region: EGF_CA; cd00054 1278073000303 Ca2+ binding site [ion binding]; other site 1278073000304 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1278073000305 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1278073000306 active site 1278073000307 metal binding site [ion binding]; metal-binding site 1278073000308 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1278073000309 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1278073000310 putative active site [active] 1278073000311 putative metal binding site [ion binding]; other site 1278073000312 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 1278073000313 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 1278073000314 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 1278073000315 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073000316 TPR motif; other site 1278073000317 binding surface 1278073000318 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 1278073000319 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 1278073000320 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 1278073000321 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 1278073000322 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 1278073000323 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1278073000324 Cl- selectivity filter; other site 1278073000325 Cl- binding residues [ion binding]; other site 1278073000326 pore gating glutamate residue; other site 1278073000327 dimer interface [polypeptide binding]; other site 1278073000328 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1278073000329 active site 1278073000330 oxyanion hole [active] 1278073000331 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1278073000332 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1278073000333 putative active site [active] 1278073000334 catalytic triad [active] 1278073000335 putative dimer interface [polypeptide binding]; other site 1278073000336 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1278073000337 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1278073000338 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1278073000339 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1278073000340 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1278073000341 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1278073000342 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1278073000343 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1278073000344 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1278073000345 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 1278073000346 putative active site [active] 1278073000347 putative NTP binding site [chemical binding]; other site 1278073000348 putative nucleic acid binding site [nucleotide binding]; other site 1278073000349 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1278073000350 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1278073000351 structural tetrad; other site 1278073000352 HEAT repeats; Region: HEAT_2; pfam13646 1278073000353 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 1278073000354 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073000355 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073000356 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073000357 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073000358 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073000359 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073000360 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1278073000361 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1278073000362 putative acyl-acceptor binding pocket; other site 1278073000363 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1278073000364 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1278073000365 ligand binding site [chemical binding]; other site 1278073000366 flexible hinge region; other site 1278073000367 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073000368 Walker A/P-loop; other site 1278073000369 ATP binding site [chemical binding]; other site 1278073000370 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 1278073000371 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1278073000372 active site 1278073000373 metal binding site [ion binding]; metal-binding site 1278073000374 DNA binding site [nucleotide binding] 1278073000375 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073000376 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073000377 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073000378 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073000379 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073000380 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073000381 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073000382 S-adenosylmethionine binding site [chemical binding]; other site 1278073000383 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073000384 ATP binding site [chemical binding]; other site 1278073000385 Mg2+ binding site [ion binding]; other site 1278073000386 G-X-G motif; other site 1278073000387 Virus coat protein (TMV like); Region: TMV_coat; pfam00721 1278073000388 Halocarboxylic acid dehydrogenase DehI; Region: DehI; pfam10778 1278073000389 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1278073000390 DNA methylase; Region: N6_N4_Mtase; cl17433 1278073000391 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1278073000392 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1278073000393 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1278073000394 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1278073000395 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1278073000396 active site 1278073000397 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1278073000398 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1278073000399 Moco binding site; other site 1278073000400 metal coordination site [ion binding]; other site 1278073000401 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 1278073000402 Right handed beta helix region; Region: Beta_helix; pfam13229 1278073000403 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073000404 S-adenosylmethionine binding site [chemical binding]; other site 1278073000405 repeat-companion domain TIGR02996; Region: rpt_mate_G_obs 1278073000406 repeat-companion domain TIGR02996; Region: rpt_mate_G_obs 1278073000407 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 1278073000408 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1278073000409 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1278073000410 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1278073000411 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1278073000412 K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156 1278073000413 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1278073000414 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1278073000415 Ligand Binding Site [chemical binding]; other site 1278073000416 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1278073000417 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1278073000418 dimerization interface [polypeptide binding]; other site 1278073000419 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1278073000420 putative active site [active] 1278073000421 heme pocket [chemical binding]; other site 1278073000422 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073000423 dimer interface [polypeptide binding]; other site 1278073000424 phosphorylation site [posttranslational modification] 1278073000425 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073000426 ATP binding site [chemical binding]; other site 1278073000427 G-X-G motif; other site 1278073000428 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073000429 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073000430 active site 1278073000431 ATP binding site [chemical binding]; other site 1278073000432 substrate binding site [chemical binding]; other site 1278073000433 activation loop (A-loop); other site 1278073000434 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1278073000435 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073000436 binding surface 1278073000437 TPR motif; other site 1278073000438 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1278073000439 Tetratricopeptide repeat; Region: TPR_10; pfam13374 1278073000440 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1278073000441 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1278073000442 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073000443 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073000444 active site 1278073000445 ATP binding site [chemical binding]; other site 1278073000446 substrate binding site [chemical binding]; other site 1278073000447 activation loop (A-loop); other site 1278073000448 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1278073000449 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073000450 binding surface 1278073000451 TPR motif; other site 1278073000452 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1278073000453 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1278073000454 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073000455 active site 1278073000456 phosphorylation site [posttranslational modification] 1278073000457 intermolecular recognition site; other site 1278073000458 dimerization interface [polypeptide binding]; other site 1278073000459 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073000460 Walker A motif; other site 1278073000461 ATP binding site [chemical binding]; other site 1278073000462 Walker B motif; other site 1278073000463 arginine finger; other site 1278073000464 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1278073000465 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1278073000466 active site 1278073000467 phosphorylation site [posttranslational modification] 1278073000468 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1278073000469 active site 1278073000470 phosphorylation site [posttranslational modification] 1278073000471 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073000472 Uncharacterized conserved protein [Function unknown]; Region: COG3268 1278073000473 NAD(P) binding site [chemical binding]; other site 1278073000474 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1278073000475 dimerization interface [polypeptide binding]; other site 1278073000476 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1278073000477 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1278073000478 dimer interface [polypeptide binding]; other site 1278073000479 putative CheW interface [polypeptide binding]; other site 1278073000480 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1278073000481 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1278073000482 Potassium binding sites [ion binding]; other site 1278073000483 Cesium cation binding sites [ion binding]; other site 1278073000484 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1278073000485 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1278073000486 active site residue [active] 1278073000487 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1278073000488 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073000489 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1278073000490 Walker A motif; other site 1278073000491 ATP binding site [chemical binding]; other site 1278073000492 Walker B motif; other site 1278073000493 arginine finger; other site 1278073000494 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1278073000495 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1278073000496 N-myristoyl transferase [Lipid metabolism]; Region: NMT1; COG5092 1278073000497 Predicted lipoprotein of unknown function (DUF2380); Region: DUF2380; cl15289 1278073000498 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1278073000499 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 1278073000500 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 1278073000501 putative ligand binding site [chemical binding]; other site 1278073000502 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 1278073000503 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1278073000504 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 1278073000505 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1278073000506 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1278073000507 metal ion-dependent adhesion site (MIDAS); other site 1278073000508 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1278073000509 PAS domain S-box; Region: sensory_box; TIGR00229 1278073000510 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1278073000511 putative active site [active] 1278073000512 heme pocket [chemical binding]; other site 1278073000513 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1278073000514 GAF domain; Region: GAF; pfam01590 1278073000515 PAS fold; Region: PAS_3; pfam08447 1278073000516 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1278073000517 PAS domain; Region: PAS_8; pfam13188 1278073000518 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073000519 dimer interface [polypeptide binding]; other site 1278073000520 phosphorylation site [posttranslational modification] 1278073000521 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073000522 ATP binding site [chemical binding]; other site 1278073000523 Mg2+ binding site [ion binding]; other site 1278073000524 G-X-G motif; other site 1278073000525 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073000526 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073000527 active site 1278073000528 phosphorylation site [posttranslational modification] 1278073000529 intermolecular recognition site; other site 1278073000530 dimerization interface [polypeptide binding]; other site 1278073000531 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1278073000532 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073000533 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073000534 dimer interface [polypeptide binding]; other site 1278073000535 phosphorylation site [posttranslational modification] 1278073000536 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073000537 ATP binding site [chemical binding]; other site 1278073000538 Mg2+ binding site [ion binding]; other site 1278073000539 G-X-G motif; other site 1278073000540 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073000541 dimer interface [polypeptide binding]; other site 1278073000542 phosphorylation site [posttranslational modification] 1278073000543 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073000544 ATP binding site [chemical binding]; other site 1278073000545 Mg2+ binding site [ion binding]; other site 1278073000546 G-X-G motif; other site 1278073000547 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1278073000548 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1278073000549 active site residue [active] 1278073000550 EamA-like transporter family; Region: EamA; pfam00892 1278073000551 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1278073000552 EamA-like transporter family; Region: EamA; pfam00892 1278073000553 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1278073000554 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1278073000555 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1278073000556 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1278073000557 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1278073000558 RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678 1278073000559 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1278073000560 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073000561 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1278073000562 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1278073000563 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1278073000564 active site 1278073000565 catalytic residues [active] 1278073000566 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_4; cd07822 1278073000567 putative hydrophobic ligand binding site [chemical binding]; other site 1278073000568 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1278073000569 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1278073000570 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1278073000571 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1278073000572 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1278073000573 catalytic residue [active] 1278073000574 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 1278073000575 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073000576 NAD(P) binding site [chemical binding]; other site 1278073000577 active site 1278073000578 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1278073000579 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1278073000580 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1278073000581 homodimer interface [polypeptide binding]; other site 1278073000582 catalytic residue [active] 1278073000583 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1278073000584 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1278073000585 putative DNA binding site [nucleotide binding]; other site 1278073000586 putative Zn2+ binding site [ion binding]; other site 1278073000587 AsnC family; Region: AsnC_trans_reg; pfam01037 1278073000588 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1278073000589 putative substrate translocation pore; other site 1278073000590 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1278073000591 TraB family; Region: TraB; pfam01963 1278073000592 Domain of unknown function (DUF4329); Region: DUF4329; pfam14220 1278073000593 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1278073000594 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1278073000595 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1278073000596 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1278073000597 dimer interface [polypeptide binding]; other site 1278073000598 active site 1278073000599 CoA binding pocket [chemical binding]; other site 1278073000600 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1278073000601 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1278073000602 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1278073000603 acyl-activating enzyme (AAE) consensus motif; other site 1278073000604 putative AMP binding site [chemical binding]; other site 1278073000605 putative active site [active] 1278073000606 putative CoA binding site [chemical binding]; other site 1278073000607 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1278073000608 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1278073000609 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1278073000610 Pleckstrin homology-like domain; Region: PH-like; cl17171 1278073000611 Lipase (class 2); Region: Lipase_2; pfam01674 1278073000612 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1278073000613 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR3; cd08275 1278073000614 putative NAD(P) binding site [chemical binding]; other site 1278073000615 Uncharacterized conserved protein [Function unknown]; Region: COG5276 1278073000616 peptide chain release factor 2; Provisional; Region: PRK05589 1278073000617 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1278073000618 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1278073000619 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1278073000620 acyl-activating enzyme (AAE) consensus motif; other site 1278073000621 acyl-activating enzyme (AAE) consensus motif; other site 1278073000622 putative AMP binding site [chemical binding]; other site 1278073000623 putative active site [active] 1278073000624 putative CoA binding site [chemical binding]; other site 1278073000625 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1278073000626 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073000627 active site 1278073000628 phosphorylation site [posttranslational modification] 1278073000629 intermolecular recognition site; other site 1278073000630 dimerization interface [polypeptide binding]; other site 1278073000631 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1278073000632 DNA binding site [nucleotide binding] 1278073000633 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073000634 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1278073000635 dimerization interface [polypeptide binding]; other site 1278073000636 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073000637 dimer interface [polypeptide binding]; other site 1278073000638 phosphorylation site [posttranslational modification] 1278073000639 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073000640 ATP binding site [chemical binding]; other site 1278073000641 G-X-G motif; other site 1278073000642 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1278073000643 sequence-specific DNA binding site [nucleotide binding]; other site 1278073000644 salt bridge; other site 1278073000645 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1278073000646 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073000647 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1278073000648 DNA binding residues [nucleotide binding] 1278073000649 DNA polymerase III subunit beta; Validated; Region: PRK05643 1278073000650 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1278073000651 putative DNA binding surface [nucleotide binding]; other site 1278073000652 dimer interface [polypeptide binding]; other site 1278073000653 beta-clamp/clamp loader binding surface; other site 1278073000654 beta-clamp/translesion DNA polymerase binding surface; other site 1278073000655 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 1278073000656 PAS fold; Region: PAS_4; pfam08448 1278073000657 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1278073000658 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073000659 dimer interface [polypeptide binding]; other site 1278073000660 phosphorylation site [posttranslational modification] 1278073000661 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073000662 ATP binding site [chemical binding]; other site 1278073000663 Mg2+ binding site [ion binding]; other site 1278073000664 G-X-G motif; other site 1278073000665 recombination protein F; Reviewed; Region: recF; PRK00064 1278073000666 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073000667 Walker A/P-loop; other site 1278073000668 ATP binding site [chemical binding]; other site 1278073000669 Q-loop/lid; other site 1278073000670 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073000671 ABC transporter signature motif; other site 1278073000672 Walker B; other site 1278073000673 D-loop; other site 1278073000674 H-loop/switch region; other site 1278073000675 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1278073000676 Permease; Region: Permease; pfam02405 1278073000677 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1278073000678 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1278073000679 Walker A/P-loop; other site 1278073000680 ATP binding site [chemical binding]; other site 1278073000681 Q-loop/lid; other site 1278073000682 ABC transporter signature motif; other site 1278073000683 Walker B; other site 1278073000684 D-loop; other site 1278073000685 H-loop/switch region; other site 1278073000686 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1278073000687 mce related protein; Region: MCE; pfam02470 1278073000688 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 1278073000689 active site 1278073000690 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 1278073000691 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1278073000692 metal binding site [ion binding]; metal-binding site 1278073000693 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1278073000694 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1278073000695 catalytic residue [active] 1278073000696 Myxococcales-restricted protein, TIGR02265 family; Region: Mxa_TIGR02265 1278073000697 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1278073000698 dinuclear metal binding motif [ion binding]; other site 1278073000699 Domain of unknown function (DUF2383); Region: DUF2383; cl17556 1278073000700 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073000701 active site 1278073000702 phosphorylation site [posttranslational modification] 1278073000703 intermolecular recognition site; other site 1278073000704 dimerization interface [polypeptide binding]; other site 1278073000705 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1278073000706 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1278073000707 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1278073000708 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1278073000709 Ligand Binding Site [chemical binding]; other site 1278073000710 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1278073000711 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1278073000712 non-specific DNA binding site [nucleotide binding]; other site 1278073000713 salt bridge; other site 1278073000714 sequence-specific DNA binding site [nucleotide binding]; other site 1278073000715 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 1278073000716 active site 1278073000717 phosphorylation site [posttranslational modification] 1278073000718 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1278073000719 Coenzyme A binding pocket [chemical binding]; other site 1278073000720 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1278073000721 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073000722 ATP binding site [chemical binding]; other site 1278073000723 Mg2+ binding site [ion binding]; other site 1278073000724 G-X-G motif; other site 1278073000725 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1278073000726 anchoring element; other site 1278073000727 dimer interface [polypeptide binding]; other site 1278073000728 ATP binding site [chemical binding]; other site 1278073000729 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1278073000730 active site 1278073000731 putative metal-binding site [ion binding]; other site 1278073000732 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1278073000733 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 1278073000734 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1278073000735 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073000736 active site 1278073000737 ATP binding site [chemical binding]; other site 1278073000738 substrate binding site [chemical binding]; other site 1278073000739 activation loop (A-loop); other site 1278073000740 PEGA domain; Region: PEGA; pfam08308 1278073000741 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1278073000742 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1278073000743 active site 1278073000744 metal binding site [ion binding]; metal-binding site 1278073000745 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073000746 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 1278073000747 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1278073000748 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1278073000749 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1278073000750 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1278073000751 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1278073000752 TolR protein; Region: tolR; TIGR02801 1278073000753 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618 1278073000754 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1278073000755 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 1278073000756 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1278073000757 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1278073000758 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1278073000759 Ribosome-binding factor A; Region: RBFA; pfam02033 1278073000760 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1278073000761 hypothetical protein; Reviewed; Region: PRK09588 1278073000762 Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cd11375 1278073000763 active site 1278073000764 Zn binding site [ion binding]; other site 1278073000765 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 1278073000766 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 1278073000767 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1278073000768 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1278073000769 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1278073000770 Protein of unknown function (DUF2378); Region: DUF2378; cl15288 1278073000771 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1278073000772 Cysteine-rich domain; Region: CCG; pfam02754 1278073000773 Cysteine-rich domain; Region: CCG; pfam02754 1278073000774 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1278073000775 metal ion-dependent adhesion site (MIDAS); other site 1278073000776 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 1278073000777 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1278073000778 DsbD alpha interface [polypeptide binding]; other site 1278073000779 catalytic residues [active] 1278073000780 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 1278073000781 putative catalytic residue [active] 1278073000782 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1278073000783 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1278073000784 active site 1278073000785 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1278073000786 putative substrate translocation pore; other site 1278073000787 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 1278073000788 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1278073000789 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1278073000790 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1278073000791 protein binding site [polypeptide binding]; other site 1278073000792 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1278073000793 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1278073000794 protein binding site [polypeptide binding]; other site 1278073000795 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1278073000796 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1278073000797 active site 1278073000798 TDP-binding site; other site 1278073000799 acceptor substrate-binding pocket; other site 1278073000800 homodimer interface [polypeptide binding]; other site 1278073000801 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1278073000802 Ligand Binding Site [chemical binding]; other site 1278073000803 Molecular Tunnel; other site 1278073000804 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1278073000805 FeS/SAM binding site; other site 1278073000806 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1278073000807 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1278073000808 active site 1278073000809 catalytic tetrad [active] 1278073000810 PAS domain; Region: PAS_9; pfam13426 1278073000811 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1278073000812 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1278073000813 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073000814 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073000815 dimer interface [polypeptide binding]; other site 1278073000816 phosphorylation site [posttranslational modification] 1278073000817 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073000818 ATP binding site [chemical binding]; other site 1278073000819 Mg2+ binding site [ion binding]; other site 1278073000820 G-X-G motif; other site 1278073000821 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1278073000822 active site 1278073000823 AMP binding site [chemical binding]; other site 1278073000824 acyl-activating enzyme (AAE) consensus motif; other site 1278073000825 CoA binding site [chemical binding]; other site 1278073000826 MoxR-like ATPases [General function prediction only]; Region: COG0714 1278073000827 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073000828 Walker A motif; other site 1278073000829 ATP binding site [chemical binding]; other site 1278073000830 Walker B motif; other site 1278073000831 arginine finger; other site 1278073000832 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1278073000833 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1278073000834 DNA binding residues [nucleotide binding] 1278073000835 dimerization interface [polypeptide binding]; other site 1278073000836 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1278073000837 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1278073000838 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1278073000839 active site 1278073000840 PAS domain; Region: PAS_9; pfam13426 1278073000841 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1278073000842 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1278073000843 putative active site [active] 1278073000844 heme pocket [chemical binding]; other site 1278073000845 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073000846 ATP binding site [chemical binding]; other site 1278073000847 Mg2+ binding site [ion binding]; other site 1278073000848 G-X-G motif; other site 1278073000849 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1278073000850 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073000851 active site 1278073000852 phosphorylation site [posttranslational modification] 1278073000853 intermolecular recognition site; other site 1278073000854 dimerization interface [polypeptide binding]; other site 1278073000855 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1278073000856 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 1278073000857 Protein of unknown function, DUF482; Region: DUF482; pfam04339 1278073000858 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1278073000859 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1278073000860 putative di-iron ligands [ion binding]; other site 1278073000861 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1278073000862 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1278073000863 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 1278073000864 inhibitor-cofactor binding pocket; inhibition site 1278073000865 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1278073000866 catalytic residue [active] 1278073000867 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1278073000868 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 1278073000869 Phage Tail Collar Domain; Region: Collar; pfam07484 1278073000870 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 1278073000871 maltose O-acetyltransferase; Provisional; Region: PRK10092 1278073000872 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1278073000873 active site 1278073000874 substrate binding site [chemical binding]; other site 1278073000875 trimer interface [polypeptide binding]; other site 1278073000876 CoA binding site [chemical binding]; other site 1278073000877 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1278073000878 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1278073000879 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1278073000880 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1278073000881 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1278073000882 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1278073000883 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1278073000884 catalytic site [active] 1278073000885 active site 1278073000886 Right handed beta helix region; Region: Beta_helix; pfam13229 1278073000887 Right handed beta helix region; Region: Beta_helix; pfam13229 1278073000888 Cys-rich repeat, Myxococcales-type; Region: Myxo_Cys_RPT; TIGR04201 1278073000889 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1278073000890 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1278073000891 ligand binding site [chemical binding]; other site 1278073000892 5'-3' exonuclease; Region: 53EXOc; smart00475 1278073000893 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1278073000894 active site 1278073000895 metal binding site 1 [ion binding]; metal-binding site 1278073000896 putative 5' ssDNA interaction site; other site 1278073000897 metal binding site 3; metal-binding site 1278073000898 metal binding site 2 [ion binding]; metal-binding site 1278073000899 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1278073000900 putative DNA binding site [nucleotide binding]; other site 1278073000901 putative metal binding site [ion binding]; other site 1278073000902 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1278073000903 apolar tunnel; other site 1278073000904 heme binding site [chemical binding]; other site 1278073000905 dimerization interface [polypeptide binding]; other site 1278073000906 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1278073000907 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1278073000908 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1278073000909 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1278073000910 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1278073000911 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1278073000912 putative di-iron ligands [ion binding]; other site 1278073000913 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1278073000914 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 1278073000915 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1278073000916 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073000917 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1278073000918 DNA binding residues [nucleotide binding] 1278073000919 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073000920 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073000921 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073000922 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073000923 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073000924 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073000925 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073000926 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073000927 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073000928 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 1278073000929 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 1278073000930 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 1278073000931 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 1278073000932 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1278073000933 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1278073000934 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1278073000935 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1278073000936 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1278073000937 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1278073000938 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1278073000939 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1278073000940 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 1278073000941 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1278073000942 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1278073000943 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1278073000944 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 1278073000945 conserved hypothetical protein; Region: TIGR02270 1278073000946 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 1278073000947 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 1278073000948 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1278073000949 GAF domain; Region: GAF_3; pfam13492 1278073000950 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1278073000951 GAF domain; Region: GAF; pfam01590 1278073000952 PAS domain; Region: PAS_9; pfam13426 1278073000953 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1278073000954 putative active site [active] 1278073000955 heme pocket [chemical binding]; other site 1278073000956 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1278073000957 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1278073000958 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073000959 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073000960 dimer interface [polypeptide binding]; other site 1278073000961 phosphorylation site [posttranslational modification] 1278073000962 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073000963 ATP binding site [chemical binding]; other site 1278073000964 Mg2+ binding site [ion binding]; other site 1278073000965 G-X-G motif; other site 1278073000966 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 1278073000967 potassium uptake protein; Region: kup; TIGR00794 1278073000968 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1278073000969 active site 2 [active] 1278073000970 active site 1 [active] 1278073000971 Myxococcales-restricted protein, TIGR02265 family; Region: Mxa_TIGR02265 1278073000972 Deinococcus radiodurans DR1119 and related proteins, metallophosphatase domain; Region: MPP_DR1119; cd07393 1278073000973 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1278073000974 putative active site [active] 1278073000975 putative metal binding site [ion binding]; other site 1278073000976 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1278073000977 amidase catalytic site [active] 1278073000978 Zn binding residues [ion binding]; other site 1278073000979 substrate binding site [chemical binding]; other site 1278073000980 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 1278073000981 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1278073000982 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1278073000983 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1278073000984 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1278073000985 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1278073000986 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1278073000987 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 1278073000988 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1278073000989 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1278073000990 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1278073000991 phosphopeptide binding site; other site 1278073000992 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073000993 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1278073000994 Walker A motif; other site 1278073000995 ATP binding site [chemical binding]; other site 1278073000996 Walker B motif; other site 1278073000997 arginine finger; other site 1278073000998 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1278073000999 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 1278073001000 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1278073001001 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1278073001002 active site 1278073001003 HIGH motif; other site 1278073001004 nucleotide binding site [chemical binding]; other site 1278073001005 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1278073001006 active site 1278073001007 KMSKS motif; other site 1278073001008 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1278073001009 tRNA binding surface [nucleotide binding]; other site 1278073001010 anticodon binding site; other site 1278073001011 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1278073001012 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 1278073001013 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1278073001014 Domain of unknown function (DUF4114); Region: DUF4114; pfam13448 1278073001015 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 1278073001016 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 1278073001017 Uncharacterized conserved protein [Function unknown]; Region: COG1656 1278073001018 Protein of unknown function DUF82; Region: DUF82; pfam01927 1278073001019 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1278073001020 putative catalytic site [active] 1278073001021 putative metal binding site [ion binding]; other site 1278073001022 putative phosphate binding site [ion binding]; other site 1278073001023 Protein of unknown function (DUF1279); Region: DUF1279; pfam06916 1278073001024 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1278073001025 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1278073001026 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1278073001027 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 1278073001028 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073001029 active site 1278073001030 phosphorylation site [posttranslational modification] 1278073001031 intermolecular recognition site; other site 1278073001032 dimerization interface [polypeptide binding]; other site 1278073001033 LytTr DNA-binding domain; Region: LytTR; smart00850 1278073001034 Histidine kinase; Region: His_kinase; pfam06580 1278073001035 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1278073001036 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1278073001037 SWIB/MDM2 domain; Region: SWIB; cl02489 1278073001038 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 1278073001039 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1278073001040 MgtE intracellular N domain; Region: MgtE_N; smart00924 1278073001041 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1278073001042 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1278073001043 Divalent cation transporter; Region: MgtE; pfam01769 1278073001044 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1278073001045 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1278073001046 dimerization interface [polypeptide binding]; other site 1278073001047 DNA binding residues [nucleotide binding] 1278073001048 Predicted membrane protein [Function unknown]; Region: COG3503 1278073001049 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) hydroxylase; Region: Kdo_hydroxy; pfam11004 1278073001050 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 1278073001051 active site 1278073001052 catalytic triad [active] 1278073001053 oxyanion hole [active] 1278073001054 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1278073001055 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1278073001056 RibD C-terminal domain; Region: RibD_C; cl17279 1278073001057 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1278073001058 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_15; cd07264 1278073001059 HTH domain; Region: HTH_11; pfam08279 1278073001060 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1278073001061 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1278073001062 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1278073001063 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1278073001064 catalytic site [active] 1278073001065 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1278073001066 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1278073001067 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1278073001068 inhibitor-cofactor binding pocket; inhibition site 1278073001069 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1278073001070 catalytic residue [active] 1278073001071 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073001072 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073001073 active site 1278073001074 ATP binding site [chemical binding]; other site 1278073001075 substrate binding site [chemical binding]; other site 1278073001076 activation loop (A-loop); other site 1278073001077 PAS fold; Region: PAS_4; pfam08448 1278073001078 GAF domain; Region: GAF; pfam01590 1278073001079 GAF domain; Region: GAF_2; pfam13185 1278073001080 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1278073001081 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1278073001082 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073001083 dimer interface [polypeptide binding]; other site 1278073001084 phosphorylation site [posttranslational modification] 1278073001085 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073001086 ATP binding site [chemical binding]; other site 1278073001087 Mg2+ binding site [ion binding]; other site 1278073001088 G-X-G motif; other site 1278073001089 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1278073001090 substrate binding site [chemical binding]; other site 1278073001091 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 1278073001092 ATP synthase A chain; Region: ATP-synt_A; cl00413 1278073001093 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1278073001094 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1278073001095 GTP-binding protein YchF; Reviewed; Region: PRK09601 1278073001096 YchF GTPase; Region: YchF; cd01900 1278073001097 G1 box; other site 1278073001098 GTP/Mg2+ binding site [chemical binding]; other site 1278073001099 Switch I region; other site 1278073001100 G2 box; other site 1278073001101 Switch II region; other site 1278073001102 G3 box; other site 1278073001103 G4 box; other site 1278073001104 G5 box; other site 1278073001105 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1278073001106 Helix-turn-helix domain; Region: HTH_17; pfam12728 1278073001107 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 1278073001108 Citrate synthase; Region: Citrate_synt; pfam00285 1278073001109 dimer interface [polypeptide binding]; other site 1278073001110 active site 1278073001111 oxalacetate/citrate binding site [chemical binding]; other site 1278073001112 citrylCoA binding site [chemical binding]; other site 1278073001113 coenzyme A binding site [chemical binding]; other site 1278073001114 catalytic triad [active] 1278073001115 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1278073001116 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073001117 Cupin domain; Region: Cupin_2; cl17218 1278073001118 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 1278073001119 Cytochrome oxidase complex assembly protein 1; Region: Coa1; pfam08695 1278073001120 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1278073001121 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1278073001122 putative active site [active] 1278073001123 putative metal binding site [ion binding]; other site 1278073001124 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 1278073001125 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 1278073001126 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1278073001127 NlpC/P60 family; Region: NLPC_P60; cl17555 1278073001128 Uncharacterized conserved protein [Function unknown]; Region: COG1915 1278073001129 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cl04528 1278073001130 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1278073001131 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 1278073001132 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1278073001133 active site 1278073001134 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1278073001135 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1278073001136 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1278073001137 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1278073001138 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073001139 S-adenosylmethionine binding site [chemical binding]; other site 1278073001140 Double zinc ribbon; Region: DZR; pfam12773 1278073001141 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1278073001142 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1278073001143 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1278073001144 MOSC domain; Region: MOSC; pfam03473 1278073001145 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 1278073001146 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 1278073001147 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1278073001148 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1278073001149 Protein of unknown function (DUF3349); Region: DUF3349; pfam11829 1278073001150 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1278073001151 active site 1278073001152 catalytic residues [active] 1278073001153 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1278073001154 GtrA-like protein; Region: GtrA; pfam04138 1278073001155 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 1278073001156 active site 1278073001157 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 1278073001158 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 1278073001159 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1278073001160 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1278073001161 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 1278073001162 putative NAD(P) binding site [chemical binding]; other site 1278073001163 putative substrate binding site [chemical binding]; other site 1278073001164 catalytic Zn binding site [ion binding]; other site 1278073001165 structural Zn binding site [ion binding]; other site 1278073001166 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1278073001167 30S subunit binding site; other site 1278073001168 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 1278073001169 Predicted membrane protein [Function unknown]; Region: COG3463 1278073001170 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073001171 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073001172 active site 1278073001173 phosphorylation site [posttranslational modification] 1278073001174 intermolecular recognition site; other site 1278073001175 dimerization interface [polypeptide binding]; other site 1278073001176 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1278073001177 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073001178 dimer interface [polypeptide binding]; other site 1278073001179 phosphorylation site [posttranslational modification] 1278073001180 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073001181 ATP binding site [chemical binding]; other site 1278073001182 Mg2+ binding site [ion binding]; other site 1278073001183 G-X-G motif; other site 1278073001184 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073001185 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073001186 active site 1278073001187 phosphorylation site [posttranslational modification] 1278073001188 intermolecular recognition site; other site 1278073001189 dimerization interface [polypeptide binding]; other site 1278073001190 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073001191 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073001192 active site 1278073001193 phosphorylation site [posttranslational modification] 1278073001194 intermolecular recognition site; other site 1278073001195 dimerization interface [polypeptide binding]; other site 1278073001196 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073001197 ATP binding site [chemical binding]; other site 1278073001198 Mg2+ binding site [ion binding]; other site 1278073001199 G-X-G motif; other site 1278073001200 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1278073001201 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073001202 active site 1278073001203 phosphorylation site [posttranslational modification] 1278073001204 intermolecular recognition site; other site 1278073001205 SnoaL-like domain; Region: SnoaL_3; pfam13474 1278073001206 SnoaL-like domain; Region: SnoaL_2; pfam12680 1278073001207 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1278073001208 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1278073001209 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1278073001210 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 1278073001211 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03095 1278073001212 SurA N-terminal domain; Region: SurA_N; pfam09312 1278073001213 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1278073001214 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 1278073001215 SurA N-terminal domain; Region: SurA_N_3; cl07813 1278073001216 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1278073001217 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1278073001218 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1278073001219 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1278073001220 GIY-YIG motif/motif A; other site 1278073001221 putative active site [active] 1278073001222 putative metal binding site [ion binding]; other site 1278073001223 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 1278073001224 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1278073001225 FeS/SAM binding site; other site 1278073001226 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 1278073001227 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 1278073001228 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1278073001229 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1278073001230 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1278073001231 putative NADH binding site [chemical binding]; other site 1278073001232 putative active site [active] 1278073001233 nudix motif; other site 1278073001234 putative metal binding site [ion binding]; other site 1278073001235 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1278073001236 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1278073001237 dimer interface [polypeptide binding]; other site 1278073001238 active site 1278073001239 metal binding site [ion binding]; metal-binding site 1278073001240 glutathione binding site [chemical binding]; other site 1278073001241 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1278073001242 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1278073001243 FMN binding site [chemical binding]; other site 1278073001244 substrate binding site [chemical binding]; other site 1278073001245 putative catalytic residue [active] 1278073001246 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1278073001247 Coenzyme A binding pocket [chemical binding]; other site 1278073001248 TPR repeat; Region: TPR_11; pfam13414 1278073001249 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073001250 binding surface 1278073001251 TPR motif; other site 1278073001252 PEGA domain; Region: PEGA; pfam08308 1278073001253 PEGA domain; Region: PEGA; pfam08308 1278073001254 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 1278073001255 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1278073001256 N-terminal plug; other site 1278073001257 ligand-binding site [chemical binding]; other site 1278073001258 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1278073001259 putative active site [active] 1278073001260 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 1278073001261 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073001262 Walker A motif; other site 1278073001263 ATP binding site [chemical binding]; other site 1278073001264 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1278073001265 AAA domain; Region: AAA_12; pfam13087 1278073001266 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1278073001267 nucleotide binding site/active site [active] 1278073001268 HIT family signature motif; other site 1278073001269 catalytic residue [active] 1278073001270 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073001271 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073001272 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073001273 active site 1278073001274 phosphorylation site [posttranslational modification] 1278073001275 intermolecular recognition site; other site 1278073001276 dimerization interface [polypeptide binding]; other site 1278073001277 Bacterial Ig-like domain; Region: Big_5; pfam13205 1278073001278 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1278073001279 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073001280 active site 1278073001281 ATP binding site [chemical binding]; other site 1278073001282 substrate binding site [chemical binding]; other site 1278073001283 activation loop (A-loop); other site 1278073001284 AAA ATPase domain; Region: AAA_16; pfam13191 1278073001285 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1278073001286 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1278073001287 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1278073001288 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1278073001289 HlyD family secretion protein; Region: HlyD_3; pfam13437 1278073001290 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1278073001291 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 1278073001292 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 1278073001293 Putative peptidoglycan binding domain; Region: PG_binding_2; pfam08823 1278073001294 aspartate aminotransferase; Provisional; Region: PRK05764 1278073001295 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1278073001296 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1278073001297 homodimer interface [polypeptide binding]; other site 1278073001298 catalytic residue [active] 1278073001299 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1278073001300 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1278073001301 TLC ATP/ADP transporter; Region: TLC; cl03940 1278073001302 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 1278073001303 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1278073001304 putative NAD(P) binding site [chemical binding]; other site 1278073001305 active site 1278073001306 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1278073001307 Short C-terminal domain; Region: SHOCT; pfam09851 1278073001308 Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550 1278073001309 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1278073001310 active site 1278073001311 putative interdomain interaction site [polypeptide binding]; other site 1278073001312 putative metal-binding site [ion binding]; other site 1278073001313 putative nucleotide binding site [chemical binding]; other site 1278073001314 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 1278073001315 domain I; other site 1278073001316 phosphate binding site [ion binding]; other site 1278073001317 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 1278073001318 domain II; other site 1278073001319 domain III; other site 1278073001320 nucleotide binding site [chemical binding]; other site 1278073001321 DNA binding groove [nucleotide binding] 1278073001322 catalytic site [active] 1278073001323 domain IV; other site 1278073001324 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1278073001325 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1278073001326 ATP binding site [chemical binding]; other site 1278073001327 putative Mg++ binding site [ion binding]; other site 1278073001328 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1278073001329 nucleotide binding region [chemical binding]; other site 1278073001330 ATP-binding site [chemical binding]; other site 1278073001331 HRDC domain; Region: HRDC; pfam00570 1278073001332 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1278073001333 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1278073001334 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1278073001335 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 1278073001336 putative active site [active] 1278073001337 catalytic site [active] 1278073001338 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 1278073001339 putative active site [active] 1278073001340 catalytic site [active] 1278073001341 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1278073001342 active site 1278073001343 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1278073001344 active site 1278073001345 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1278073001346 active site 1278073001347 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073001348 Walker A motif; other site 1278073001349 ATP binding site [chemical binding]; other site 1278073001350 Walker B motif; other site 1278073001351 arginine finger; other site 1278073001352 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1278073001353 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 1278073001354 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1278073001355 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1278073001356 catalytic site [active] 1278073001357 active site 1278073001358 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1278073001359 hypothetical protein; Provisional; Region: PRK07907 1278073001360 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682 1278073001361 metal binding site [ion binding]; metal-binding site 1278073001362 putative dimer interface [polypeptide binding]; other site 1278073001363 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1278073001364 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1278073001365 substrate binding pocket [chemical binding]; other site 1278073001366 catalytic triad [active] 1278073001367 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1278073001368 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073001369 active site 1278073001370 ATP binding site [chemical binding]; other site 1278073001371 substrate binding site [chemical binding]; other site 1278073001372 activation loop (A-loop); other site 1278073001373 PEGA domain; Region: PEGA; pfam08308 1278073001374 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1278073001375 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1278073001376 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1278073001377 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1278073001378 Walker A/P-loop; other site 1278073001379 ATP binding site [chemical binding]; other site 1278073001380 Q-loop/lid; other site 1278073001381 ABC transporter signature motif; other site 1278073001382 Walker B; other site 1278073001383 D-loop; other site 1278073001384 H-loop/switch region; other site 1278073001385 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1278073001386 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1278073001387 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1278073001388 ABC transporter; Region: ABC_tran_2; pfam12848 1278073001389 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1278073001390 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1278073001391 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1278073001392 putative active site [active] 1278073001393 Bacterial PH domain; Region: DUF304; pfam03703 1278073001394 Bacterial PH domain; Region: DUF304; pfam03703 1278073001395 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1278073001396 Coenzyme A binding pocket [chemical binding]; other site 1278073001397 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 1278073001398 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1278073001399 Myxococcales-restricted protein, TIGR02265 family; Region: Mxa_TIGR02265 1278073001400 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1278073001401 Putative esterase; Region: Esterase; pfam00756 1278073001402 Staphylococcal nuclease homologues; Region: SNc; smart00318 1278073001403 Catalytic site; other site 1278073001404 Staphylococcal nuclease homologue; Region: SNase; pfam00565 1278073001405 PAS fold; Region: PAS_4; pfam08448 1278073001406 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1278073001407 putative active site [active] 1278073001408 heme pocket [chemical binding]; other site 1278073001409 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1278073001410 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1278073001411 putative active site [active] 1278073001412 heme pocket [chemical binding]; other site 1278073001413 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1278073001414 putative active site [active] 1278073001415 heme pocket [chemical binding]; other site 1278073001416 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073001417 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073001418 dimer interface [polypeptide binding]; other site 1278073001419 phosphorylation site [posttranslational modification] 1278073001420 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073001421 ATP binding site [chemical binding]; other site 1278073001422 Mg2+ binding site [ion binding]; other site 1278073001423 G-X-G motif; other site 1278073001424 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1278073001425 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1278073001426 active site 1278073001427 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 1278073001428 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1278073001429 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1278073001430 Walker A motif; other site 1278073001431 ATP binding site [chemical binding]; other site 1278073001432 Walker B motif; other site 1278073001433 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 1278073001434 Uncharacterized conserved protein [Function unknown]; Region: COG5361 1278073001435 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 1278073001436 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 1278073001437 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1278073001438 Coenzyme A binding pocket [chemical binding]; other site 1278073001439 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1278073001440 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1278073001441 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 1278073001442 dimer interface [polypeptide binding]; other site 1278073001443 putative metal binding site [ion binding]; other site 1278073001444 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 1278073001445 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 1278073001446 Protein of unknown function (DUF1175); Region: DUF1175; cl14898 1278073001447 MG2 domain; Region: A2M_N; pfam01835 1278073001448 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 1278073001449 Alpha-2-macroglobulin family; Region: A2M; pfam00207 1278073001450 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 1278073001451 surface patch; other site 1278073001452 thioester region; other site 1278073001453 Stage II sporulation protein; Region: SpoIID; pfam08486 1278073001454 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073001455 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1278073001456 dimerization interface [polypeptide binding]; other site 1278073001457 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073001458 dimer interface [polypeptide binding]; other site 1278073001459 phosphorylation site [posttranslational modification] 1278073001460 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073001461 ATP binding site [chemical binding]; other site 1278073001462 Mg2+ binding site [ion binding]; other site 1278073001463 G-X-G motif; other site 1278073001464 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1278073001465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073001466 active site 1278073001467 phosphorylation site [posttranslational modification] 1278073001468 intermolecular recognition site; other site 1278073001469 dimerization interface [polypeptide binding]; other site 1278073001470 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1278073001471 DNA binding site [nucleotide binding] 1278073001472 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1278073001473 Beta-lactamase; Region: Beta-lactamase; pfam00144 1278073001474 Zinc-dependent metalloprotease, pappalysin_like subfamily. The pregnancy-associated plasma protein A (PAPP-A or pappalysin-1) cleaves insulin-like growth factor-binding proteins 4 and 5, thereby promoting cell growth by releasing bound growth factor; Region: ZnMc_pappalysin_like; cd04275 1278073001475 active site 1278073001476 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 1278073001477 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073001478 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 1278073001479 Walker A/P-loop; other site 1278073001480 ATP binding site [chemical binding]; other site 1278073001481 Q-loop/lid; other site 1278073001482 ABC transporter signature motif; other site 1278073001483 Walker B; other site 1278073001484 D-loop; other site 1278073001485 H-loop/switch region; other site 1278073001486 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1278073001487 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1278073001488 dimer interface [polypeptide binding]; other site 1278073001489 conserved gate region; other site 1278073001490 ABC-ATPase subunit interface; other site 1278073001491 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1278073001492 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1278073001493 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073001494 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1278073001495 Walker A motif; other site 1278073001496 ATP binding site [chemical binding]; other site 1278073001497 Walker B motif; other site 1278073001498 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 1278073001499 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1278073001500 NAD(P) binding site [chemical binding]; other site 1278073001501 catalytic residues [active] 1278073001502 FHA domain; Region: FHA; pfam00498 1278073001503 phosphopeptide binding site; other site 1278073001504 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1278073001505 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073001506 Walker A motif; other site 1278073001507 ATP binding site [chemical binding]; other site 1278073001508 Walker B motif; other site 1278073001509 arginine finger; other site 1278073001510 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073001511 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073001512 active site 1278073001513 ATP binding site [chemical binding]; other site 1278073001514 substrate binding site [chemical binding]; other site 1278073001515 activation loop (A-loop); other site 1278073001516 PEGA domain; Region: PEGA; pfam08308 1278073001517 PEGA domain; Region: PEGA; pfam08308 1278073001518 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1278073001519 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 1278073001520 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1278073001521 active site 1278073001522 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1278073001523 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 1278073001524 putative active site [active] 1278073001525 Zn binding site [ion binding]; other site 1278073001526 serine O-acetyltransferase; Region: cysE; TIGR01172 1278073001527 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1278073001528 trimer interface [polypeptide binding]; other site 1278073001529 active site 1278073001530 substrate binding site [chemical binding]; other site 1278073001531 CoA binding site [chemical binding]; other site 1278073001532 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1278073001533 putative active site [active] 1278073001534 heme pocket [chemical binding]; other site 1278073001535 GAF domain; Region: GAF; cl17456 1278073001536 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1278073001537 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1278073001538 putative active site [active] 1278073001539 heme pocket [chemical binding]; other site 1278073001540 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073001541 dimer interface [polypeptide binding]; other site 1278073001542 phosphorylation site [posttranslational modification] 1278073001543 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073001544 ATP binding site [chemical binding]; other site 1278073001545 Mg2+ binding site [ion binding]; other site 1278073001546 G-X-G motif; other site 1278073001547 HEAT repeats; Region: HEAT_2; pfam13646 1278073001548 HEAT repeats; Region: HEAT_2; pfam13646 1278073001549 Family description; Region: VCBS; pfam13517 1278073001550 Family description; Region: VCBS; pfam13517 1278073001551 Family description; Region: VCBS; pfam13517 1278073001552 Family description; Region: VCBS; pfam13517 1278073001553 Family description; Region: VCBS; pfam13517 1278073001554 Family description; Region: VCBS; pfam13517 1278073001555 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1278073001556 putative hydrophobic ligand binding site [chemical binding]; other site 1278073001557 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1278073001558 dimerization interface [polypeptide binding]; other site 1278073001559 putative DNA binding site [nucleotide binding]; other site 1278073001560 putative Zn2+ binding site [ion binding]; other site 1278073001561 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1278073001562 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 1278073001563 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1278073001564 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1278073001565 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1278073001566 thioester formation/cholesterol transfer; other site 1278073001567 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1278073001568 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1278073001569 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1278073001570 active site 1278073001571 Zn binding site [ion binding]; other site 1278073001572 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1278073001573 Zn binding site [ion binding]; other site 1278073001574 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1278073001575 protein-splicing catalytic site; other site 1278073001576 thioester formation/cholesterol transfer; other site 1278073001577 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734 1278073001578 PilZ domain; Region: PilZ; pfam07238 1278073001579 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1278073001580 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1278073001581 RHS Repeat; Region: RHS_repeat; pfam05593 1278073001582 RHS Repeat; Region: RHS_repeat; pfam05593 1278073001583 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1278073001584 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 1278073001585 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1278073001586 DNA ligase; Provisional; Region: PRK09125 1278073001587 Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896 1278073001588 DNA binding site [nucleotide binding] 1278073001589 active site 1278073001590 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041 1278073001591 DNA binding site [nucleotide binding] 1278073001592 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073001593 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073001594 active site 1278073001595 ATP binding site [chemical binding]; other site 1278073001596 substrate binding site [chemical binding]; other site 1278073001597 activation loop (A-loop); other site 1278073001598 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1278073001599 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073001600 binding surface 1278073001601 TPR motif; other site 1278073001602 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073001603 TPR motif; other site 1278073001604 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1278073001605 binding surface 1278073001606 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073001607 binding surface 1278073001608 TPR motif; other site 1278073001609 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1278073001610 GON domain; Region: GON; pfam08685 1278073001611 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1278073001612 AAA domain; Region: AAA_33; pfam13671 1278073001613 ATP-binding site [chemical binding]; other site 1278073001614 Gluconate-6-phosphate binding site [chemical binding]; other site 1278073001615 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1278073001616 protein-splicing catalytic site; other site 1278073001617 thioester formation/cholesterol transfer; other site 1278073001618 Astacin (Peptidase family M12A); Region: Astacin; pfam01400 1278073001619 Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to...; Region: ZnMc_astacin_like; cd04280 1278073001620 active site 1278073001621 FG-GAP repeat; Region: FG-GAP; cl15299 1278073001622 Family description; Region: VCBS; pfam13517 1278073001623 FG-GAP repeat; Region: FG-GAP; cl15299 1278073001624 Family description; Region: VCBS; pfam13517 1278073001625 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 1278073001626 Family description; Region: VCBS; pfam13517 1278073001627 Phosphotransferase enzyme family; Region: APH; pfam01636 1278073001628 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1278073001629 B3/4 domain; Region: B3_4; pfam03483 1278073001630 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1278073001631 6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254 1278073001632 putative NAD(P) binding site [chemical binding]; other site 1278073001633 catalytic Zn binding site [ion binding]; other site 1278073001634 structural Zn binding site [ion binding]; other site 1278073001635 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1278073001636 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1278073001637 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1278073001638 ABC transporter; Region: ABC_tran_2; pfam12848 1278073001639 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1278073001640 Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134 1278073001641 NAD(P) binding site [chemical binding]; other site 1278073001642 catalytic residues [active] 1278073001643 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1278073001644 Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134 1278073001645 NAD(P) binding site [chemical binding]; other site 1278073001646 catalytic residues [active] 1278073001647 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1278073001648 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cd00138 1278073001649 PLD-like domain; Region: PLDc_2; pfam13091 1278073001650 putative active site [active] 1278073001651 catalytic site [active] 1278073001652 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1278073001653 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1278073001654 putative C-terminal domain interface [polypeptide binding]; other site 1278073001655 putative GSH binding site (G-site) [chemical binding]; other site 1278073001656 putative dimer interface [polypeptide binding]; other site 1278073001657 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 1278073001658 dimer interface [polypeptide binding]; other site 1278073001659 N-terminal domain interface [polypeptide binding]; other site 1278073001660 putative substrate binding pocket (H-site) [chemical binding]; other site 1278073001661 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1278073001662 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1278073001663 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1278073001664 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cd01060 1278073001665 putative di-iron ligands [ion binding]; other site 1278073001666 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1278073001667 non-specific DNA binding site [nucleotide binding]; other site 1278073001668 salt bridge; other site 1278073001669 sequence-specific DNA binding site [nucleotide binding]; other site 1278073001670 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1278073001671 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1278073001672 P-loop; other site 1278073001673 Magnesium ion binding site [ion binding]; other site 1278073001674 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1278073001675 Magnesium ion binding site [ion binding]; other site 1278073001676 Peptidase family M48; Region: Peptidase_M48; cl12018 1278073001677 CHASE2 domain; Region: CHASE2; pfam05226 1278073001678 CHASE2 domain; Region: CHASE2; pfam05226 1278073001679 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1278073001680 cyclase homology domain; Region: CHD; cd07302 1278073001681 nucleotidyl binding site; other site 1278073001682 metal binding site [ion binding]; metal-binding site 1278073001683 dimer interface [polypeptide binding]; other site 1278073001684 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 1278073001685 TspO/MBR family; Region: TspO_MBR; pfam03073 1278073001686 PAS fold; Region: PAS; pfam00989 1278073001687 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1278073001688 putative active site [active] 1278073001689 heme pocket [chemical binding]; other site 1278073001690 PAS fold; Region: PAS_4; pfam08448 1278073001691 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073001692 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073001693 dimer interface [polypeptide binding]; other site 1278073001694 phosphorylation site [posttranslational modification] 1278073001695 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073001696 ATP binding site [chemical binding]; other site 1278073001697 Mg2+ binding site [ion binding]; other site 1278073001698 G-X-G motif; other site 1278073001699 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 1278073001700 Peptidase family M1; Region: Peptidase_M1; pfam01433 1278073001701 Zn binding site [ion binding]; other site 1278073001702 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1278073001703 HEAT repeats; Region: HEAT_2; pfam13646 1278073001704 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1278073001705 HSP70 interaction site [polypeptide binding]; other site 1278073001706 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1278073001707 putative catalytic site [active] 1278073001708 putative metal binding site [ion binding]; other site 1278073001709 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1278073001710 putative catalytic site [active] 1278073001711 putative phosphate binding site [ion binding]; other site 1278073001712 putative phosphate binding site [ion binding]; other site 1278073001713 putative metal binding site [ion binding]; other site 1278073001714 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 1278073001715 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 1278073001716 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 1278073001717 catalytic triad [active] 1278073001718 putative active site [active] 1278073001719 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1278073001720 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1278073001721 Domain of unknown function (DUF4286); Region: DUF4286; pfam14114 1278073001722 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 1278073001723 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1278073001724 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1278073001725 active site 1278073001726 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1278073001727 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1278073001728 Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: NlpB; COG3317 1278073001729 ribonuclease Z; Region: RNase_Z; TIGR02651 1278073001730 Uncharacterized conserved protein (DUF2293); Region: DUF2293; pfam10056 1278073001731 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1278073001732 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1278073001733 HlyD family secretion protein; Region: HlyD_3; pfam13437 1278073001734 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1278073001735 Protein of unknown function DUF99; Region: DUF99; pfam01949 1278073001736 hypothetical protein; Provisional; Region: PRK00766 1278073001737 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1278073001738 DNA-binding site [nucleotide binding]; DNA binding site 1278073001739 RNA-binding motif; other site 1278073001740 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 1278073001741 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 1278073001742 PBP superfamily domain; Region: PBP_like_2; cl17296 1278073001743 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 1278073001744 conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806 1278073001745 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 1278073001746 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1278073001747 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1278073001748 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1278073001749 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 1278073001750 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 1278073001751 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1278073001752 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1278073001753 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1278073001754 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1278073001755 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073001756 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1278073001757 DNA binding residues [nucleotide binding] 1278073001758 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073001759 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073001760 active site 1278073001761 phosphorylation site [posttranslational modification] 1278073001762 intermolecular recognition site; other site 1278073001763 dimerization interface [polypeptide binding]; other site 1278073001764 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1278073001765 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1278073001766 dimerization interface [polypeptide binding]; other site 1278073001767 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1278073001768 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1278073001769 dimerization interface [polypeptide binding]; other site 1278073001770 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1278073001771 dimerization interface [polypeptide binding]; other site 1278073001772 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1278073001773 dimerization interface [polypeptide binding]; other site 1278073001774 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1278073001775 dimerization interface [polypeptide binding]; other site 1278073001776 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1278073001777 dimerization interface [polypeptide binding]; other site 1278073001778 GAF domain; Region: GAF_2; pfam13185 1278073001779 GAF domain; Region: GAF; pfam01590 1278073001780 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073001781 dimer interface [polypeptide binding]; other site 1278073001782 phosphorylation site [posttranslational modification] 1278073001783 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073001784 ATP binding site [chemical binding]; other site 1278073001785 Mg2+ binding site [ion binding]; other site 1278073001786 G-X-G motif; other site 1278073001787 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073001788 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073001789 active site 1278073001790 phosphorylation site [posttranslational modification] 1278073001791 intermolecular recognition site; other site 1278073001792 dimerization interface [polypeptide binding]; other site 1278073001793 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073001794 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073001795 active site 1278073001796 phosphorylation site [posttranslational modification] 1278073001797 intermolecular recognition site; other site 1278073001798 dimerization interface [polypeptide binding]; other site 1278073001799 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 1278073001800 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1278073001801 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1278073001802 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1278073001803 active site 1278073001804 catalytic tetrad [active] 1278073001805 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1278073001806 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1278073001807 GAF domain; Region: GAF; pfam01590 1278073001808 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1278073001809 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1278073001810 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1278073001811 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073001812 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073001813 dimer interface [polypeptide binding]; other site 1278073001814 phosphorylation site [posttranslational modification] 1278073001815 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073001816 ATP binding site [chemical binding]; other site 1278073001817 Mg2+ binding site [ion binding]; other site 1278073001818 G-X-G motif; other site 1278073001819 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073001820 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073001821 active site 1278073001822 ATP binding site [chemical binding]; other site 1278073001823 substrate binding site [chemical binding]; other site 1278073001824 activation loop (A-loop); other site 1278073001825 DnaJ domain; Region: DnaJ; pfam00226 1278073001826 ABC1 family; Region: ABC1; cl17513 1278073001827 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1278073001828 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1278073001829 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073001830 active site 1278073001831 phosphorylation site [posttranslational modification] 1278073001832 intermolecular recognition site; other site 1278073001833 dimerization interface [polypeptide binding]; other site 1278073001834 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073001835 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073001836 ATP binding site [chemical binding]; other site 1278073001837 Mg2+ binding site [ion binding]; other site 1278073001838 G-X-G motif; other site 1278073001839 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1278073001840 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073001841 active site 1278073001842 phosphorylation site [posttranslational modification] 1278073001843 intermolecular recognition site; other site 1278073001844 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1278073001845 DNA binding residues [nucleotide binding] 1278073001846 dimerization interface [polypeptide binding]; other site 1278073001847 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 1278073001848 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073001849 S-adenosylmethionine binding site [chemical binding]; other site 1278073001850 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 1278073001851 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 1278073001852 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1278073001853 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073001854 active site 1278073001855 phosphorylation site [posttranslational modification] 1278073001856 intermolecular recognition site; other site 1278073001857 dimerization interface [polypeptide binding]; other site 1278073001858 PAS fold; Region: PAS_4; pfam08448 1278073001859 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073001860 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073001861 dimer interface [polypeptide binding]; other site 1278073001862 phosphorylation site [posttranslational modification] 1278073001863 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073001864 ATP binding site [chemical binding]; other site 1278073001865 Mg2+ binding site [ion binding]; other site 1278073001866 G-X-G motif; other site 1278073001867 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073001868 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073001869 active site 1278073001870 phosphorylation site [posttranslational modification] 1278073001871 intermolecular recognition site; other site 1278073001872 dimerization interface [polypeptide binding]; other site 1278073001873 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1278073001874 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073001875 active site 1278073001876 phosphorylation site [posttranslational modification] 1278073001877 intermolecular recognition site; other site 1278073001878 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1278073001879 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073001880 active site 1278073001881 phosphorylation site [posttranslational modification] 1278073001882 intermolecular recognition site; other site 1278073001883 dimerization interface [polypeptide binding]; other site 1278073001884 Uncharacterized conserved protein [Function unknown]; Region: COG3287 1278073001885 FIST N domain; Region: FIST; pfam08495 1278073001886 FIST C domain; Region: FIST_C; pfam10442 1278073001887 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 1278073001888 heme-binding residues [chemical binding]; other site 1278073001889 PAS domain S-box; Region: sensory_box; TIGR00229 1278073001890 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1278073001891 putative active site [active] 1278073001892 heme pocket [chemical binding]; other site 1278073001893 GAF domain; Region: GAF; pfam01590 1278073001894 GAF domain; Region: GAF_2; pfam13185 1278073001895 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073001896 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073001897 ATP binding site [chemical binding]; other site 1278073001898 Mg2+ binding site [ion binding]; other site 1278073001899 G-X-G motif; other site 1278073001900 ATP-dependent helicase HepA; Validated; Region: PRK04914 1278073001901 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1278073001902 ATP binding site [chemical binding]; other site 1278073001903 putative Mg++ binding site [ion binding]; other site 1278073001904 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1278073001905 nucleotide binding region [chemical binding]; other site 1278073001906 ATP-binding site [chemical binding]; other site 1278073001907 TadE-like protein; Region: TadE; pfam07811 1278073001908 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1278073001909 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1278073001910 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1278073001911 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1278073001912 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073001913 Walker A/P-loop; other site 1278073001914 ATP binding site [chemical binding]; other site 1278073001915 Q-loop/lid; other site 1278073001916 ABC transporter signature motif; other site 1278073001917 Walker B; other site 1278073001918 D-loop; other site 1278073001919 H-loop/switch region; other site 1278073001920 chaperone protein DnaJ; Provisional; Region: PRK10767 1278073001921 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1278073001922 HSP70 interaction site [polypeptide binding]; other site 1278073001923 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1278073001924 substrate binding site [polypeptide binding]; other site 1278073001925 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1278073001926 Zn binding sites [ion binding]; other site 1278073001927 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1278073001928 dimer interface [polypeptide binding]; other site 1278073001929 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 1278073001930 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1278073001931 putative ligand binding site [chemical binding]; other site 1278073001932 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1278073001933 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1278073001934 structural tetrad; other site 1278073001935 WD40 repeats; Region: WD40; smart00320 1278073001936 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1278073001937 FMN reductase; Validated; Region: fre; PRK08051 1278073001938 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1278073001939 FAD binding pocket [chemical binding]; other site 1278073001940 conserved FAD binding motif [chemical binding]; other site 1278073001941 phosphate binding motif [ion binding]; other site 1278073001942 beta-alpha-beta structure motif; other site 1278073001943 NAD binding pocket [chemical binding]; other site 1278073001944 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1278073001945 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073001946 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073001947 active site 1278073001948 ATP binding site [chemical binding]; other site 1278073001949 substrate binding site [chemical binding]; other site 1278073001950 activation loop (A-loop); other site 1278073001951 Type II/IV secretion system protein; Region: T2SE; pfam00437 1278073001952 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1278073001953 ATP binding site [chemical binding]; other site 1278073001954 Walker A motif; other site 1278073001955 hexamer interface [polypeptide binding]; other site 1278073001956 Walker B motif; other site 1278073001957 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1278073001958 ligand binding site [chemical binding]; other site 1278073001959 active site 1278073001960 UGI interface [polypeptide binding]; other site 1278073001961 catalytic site [active] 1278073001962 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1278073001963 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1278073001964 active site 2 [active] 1278073001965 active site 1 [active] 1278073001966 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073001967 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073001968 active site 1278073001969 phosphorylation site [posttranslational modification] 1278073001970 intermolecular recognition site; other site 1278073001971 dimerization interface [polypeptide binding]; other site 1278073001972 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1278073001973 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1278073001974 active site 1278073001975 TPR repeat; Region: TPR_11; pfam13414 1278073001976 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073001977 TPR motif; other site 1278073001978 DNA gyrase subunit A; Validated; Region: PRK05560 1278073001979 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1278073001980 CAP-like domain; other site 1278073001981 active site 1278073001982 primary dimer interface [polypeptide binding]; other site 1278073001983 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1278073001984 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1278073001985 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1278073001986 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1278073001987 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1278073001988 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1278073001989 pfkB-type carbohydrate kinase family protein; Region: PLN02630 1278073001990 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1278073001991 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1278073001992 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1278073001993 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1278073001994 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1278073001995 dimer interface [polypeptide binding]; other site 1278073001996 conserved gate region; other site 1278073001997 putative PBP binding loops; other site 1278073001998 ABC-ATPase subunit interface; other site 1278073001999 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1278073002000 dimer interface [polypeptide binding]; other site 1278073002001 conserved gate region; other site 1278073002002 putative PBP binding loops; other site 1278073002003 ABC-ATPase subunit interface; other site 1278073002004 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1278073002005 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073002006 Walker A/P-loop; other site 1278073002007 ATP binding site [chemical binding]; other site 1278073002008 Q-loop/lid; other site 1278073002009 ABC transporter signature motif; other site 1278073002010 Walker B; other site 1278073002011 D-loop; other site 1278073002012 H-loop/switch region; other site 1278073002013 TOBE domain; Region: TOBE_2; pfam08402 1278073002014 Protein of unknown function (DUF1232); Region: DUF1232; pfam06803 1278073002015 short chain dehydrogenase; Provisional; Region: PRK06179 1278073002016 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1278073002017 NADP binding site [chemical binding]; other site 1278073002018 active site 1278073002019 steroid binding site; other site 1278073002020 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1278073002021 PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818 1278073002022 PA/protease or protease-like domain interface [polypeptide binding]; other site 1278073002023 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 1278073002024 Zn binding site [ion binding]; other site 1278073002025 TPR repeat; Region: TPR_11; pfam13414 1278073002026 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1278073002027 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1278073002028 DNA binding residues [nucleotide binding] 1278073002029 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 1278073002030 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 1278073002031 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1278073002032 metal ion-dependent adhesion site (MIDAS); other site 1278073002033 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 1278073002034 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1278073002035 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1278073002036 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 1278073002037 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 1278073002038 dimer interface [polypeptide binding]; other site 1278073002039 active site residues [active] 1278073002040 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 1278073002041 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1278073002042 Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose; Region: GT1_Trehalose_phosphorylase; cd03792 1278073002043 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1278073002044 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1278073002045 active site 1278073002046 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 1278073002047 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1278073002048 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 1278073002049 putative dimerization interface [polypeptide binding]; other site 1278073002050 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 1278073002051 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073002052 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1278073002053 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1278073002054 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073002055 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1278073002056 DNA binding residues [nucleotide binding] 1278073002057 Putative zinc-finger; Region: zf-HC2; pfam13490 1278073002058 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1278073002059 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1278073002060 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 1278073002061 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1278073002062 catalytic residues [active] 1278073002063 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1278073002064 active site residue [active] 1278073002065 Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411 1278073002066 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1278073002067 active site 1278073002068 metal binding site [ion binding]; metal-binding site 1278073002069 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1278073002070 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1278073002071 Predicted membrane protein [Function unknown]; Region: COG2855 1278073002072 Domain of unknown function (DUF2357); Region: DUF2357; pfam09823 1278073002073 Protein of unknown function (DUF524); Region: DUF524; pfam04411 1278073002074 AAA ATPase domain; Region: AAA_16; pfam13191 1278073002075 AAA domain; Region: AAA_22; pfam13401 1278073002076 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1278073002077 nucleotide binding site/active site [active] 1278073002078 HIT family signature motif; other site 1278073002079 catalytic residue [active] 1278073002080 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b3; cd09205 1278073002081 PLD-like domain; Region: PLDc_2; pfam13091 1278073002082 putative homodimer interface [polypeptide binding]; other site 1278073002083 putative active site [active] 1278073002084 catalytic site [active] 1278073002085 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1278073002086 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1278073002087 putative Mg++ binding site [ion binding]; other site 1278073002088 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1278073002089 nucleotide binding region [chemical binding]; other site 1278073002090 ATP-binding site [chemical binding]; other site 1278073002091 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1278073002092 Catalytic site [active] 1278073002093 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1278073002094 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1278073002095 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1278073002096 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1278073002097 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1278073002098 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1278073002099 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 1278073002100 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 1278073002101 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1278073002102 active site 1278073002103 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1278073002104 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1278073002105 Beta-lactamase; Region: Beta-lactamase; pfam00144 1278073002106 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1278073002107 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1278073002108 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1278073002109 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1278073002110 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1278073002111 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1278073002112 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1278073002113 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 1278073002114 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1278073002115 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1278073002116 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1278073002117 dimer interface [polypeptide binding]; other site 1278073002118 putative CheW interface [polypeptide binding]; other site 1278073002119 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1278073002120 Peptidase family M28; Region: Peptidase_M28; pfam04389 1278073002121 metal binding site [ion binding]; metal-binding site 1278073002122 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 1278073002123 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1278073002124 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1278073002125 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1278073002126 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1278073002127 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1278073002128 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1278073002129 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1278073002130 inhibitor site; inhibition site 1278073002131 active site 1278073002132 dimer interface [polypeptide binding]; other site 1278073002133 catalytic residue [active] 1278073002134 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1278073002135 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 1278073002136 dimer interface [polypeptide binding]; other site 1278073002137 NADP binding site [chemical binding]; other site 1278073002138 catalytic residues [active] 1278073002139 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 1278073002140 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1278073002141 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1278073002142 PAS fold; Region: PAS_4; pfam08448 1278073002143 Helix-turn-helix domain; Region: HTH_18; pfam12833 1278073002144 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1278073002145 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 1278073002146 TadE-like protein; Region: TadE; pfam07811 1278073002147 TadE-like protein; Region: TadE; pfam07811 1278073002148 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1278073002149 PAS fold; Region: PAS_3; pfam08447 1278073002150 putative active site [active] 1278073002151 heme pocket [chemical binding]; other site 1278073002152 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1278073002153 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1278073002154 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1278073002155 GAF domain; Region: GAF; pfam01590 1278073002156 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1278073002157 putative active site [active] 1278073002158 PAS fold; Region: PAS_3; pfam08447 1278073002159 heme pocket [chemical binding]; other site 1278073002160 GAF domain; Region: GAF; pfam01590 1278073002161 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1278073002162 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073002163 dimer interface [polypeptide binding]; other site 1278073002164 phosphorylation site [posttranslational modification] 1278073002165 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073002166 ATP binding site [chemical binding]; other site 1278073002167 Mg2+ binding site [ion binding]; other site 1278073002168 G-X-G motif; other site 1278073002169 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1278073002170 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073002171 active site 1278073002172 phosphorylation site [posttranslational modification] 1278073002173 intermolecular recognition site; other site 1278073002174 dimerization interface [polypeptide binding]; other site 1278073002175 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073002176 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073002177 dimer interface [polypeptide binding]; other site 1278073002178 phosphorylation site [posttranslational modification] 1278073002179 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073002180 ATP binding site [chemical binding]; other site 1278073002181 Mg2+ binding site [ion binding]; other site 1278073002182 G-X-G motif; other site 1278073002183 FRG domain; Region: FRG; pfam08867 1278073002184 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1278073002185 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073002186 active site 1278073002187 phosphorylation site [posttranslational modification] 1278073002188 intermolecular recognition site; other site 1278073002189 dimerization interface [polypeptide binding]; other site 1278073002190 Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279 1278073002191 active site 1278073002192 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1278073002193 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1278073002194 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1278073002195 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1278073002196 putative substrate translocation pore; other site 1278073002197 Predicted permeases [General function prediction only]; Region: COG0679 1278073002198 MG2 domain; Region: A2M_N; pfam01835 1278073002199 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073002200 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 1278073002201 Alpha-2-macroglobulin family; Region: A2M; pfam00207 1278073002202 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1278073002203 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1)-like, classical (c) SDRs; Region: 11beta-HSD1_like_SDR_c; cd05332 1278073002204 short chain dehydrogenase; Provisional; Region: PRK06181 1278073002205 NADP binding site [chemical binding]; other site 1278073002206 homodimer interface [polypeptide binding]; other site 1278073002207 substrate binding site [chemical binding]; other site 1278073002208 active site 1278073002209 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1278073002210 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1278073002211 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1278073002212 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1278073002213 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1278073002214 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1278073002215 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1278073002216 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1278073002217 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1278073002218 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1278073002219 Caspase domain; Region: Peptidase_C14; pfam00656 1278073002220 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1278073002221 Putative serine esterase (DUF676); Region: DUF676; pfam05057 1278073002222 SnoaL-like domain; Region: SnoaL_3; pfam13474 1278073002223 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 1278073002224 Ceramidase; Region: Ceramidase; pfam05875 1278073002225 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 1278073002226 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1278073002227 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1278073002228 PilZ domain; Region: PilZ; pfam07238 1278073002229 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 1278073002230 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 1278073002231 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1278073002232 Kelch motif; Region: Kelch_1; pfam01344 1278073002233 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 1278073002234 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073002235 NAD(P) binding site [chemical binding]; other site 1278073002236 short chain dehydrogenase; Validated; Region: PRK07069 1278073002237 active site 1278073002238 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1278073002239 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 1278073002240 NADP binding site [chemical binding]; other site 1278073002241 dimer interface [polypeptide binding]; other site 1278073002242 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1278073002243 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1278073002244 The MopB_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members belong to...; Region: MopB_1; cd02762 1278073002245 putative [Fe4-S4] binding site [ion binding]; other site 1278073002246 putative molybdopterin cofactor binding site [chemical binding]; other site 1278073002247 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 1278073002248 putative molybdopterin cofactor binding site; other site 1278073002249 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1278073002250 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 1278073002251 dimer interface [polypeptide binding]; other site 1278073002252 active site 1278073002253 CoA binding pocket [chemical binding]; other site 1278073002254 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1278073002255 ligand binding site [chemical binding]; other site 1278073002256 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 1278073002257 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073002258 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1278073002259 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1278073002260 Sulfatase; Region: Sulfatase; pfam00884 1278073002261 MgtC family; Region: MgtC; pfam02308 1278073002262 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 1278073002263 Predicted membrane protein [Function unknown]; Region: COG4325 1278073002264 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 1278073002265 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 1278073002266 nucleotide binding site [chemical binding]; other site 1278073002267 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1278073002268 SBD interface [polypeptide binding]; other site 1278073002269 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 1278073002270 Inorganic pyrophosphatase; Region: Pyrophosphatase; pfam00719 1278073002271 dimer interface [polypeptide binding]; other site 1278073002272 substrate binding site [chemical binding]; other site 1278073002273 metal binding sites [ion binding]; metal-binding site 1278073002274 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1278073002275 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1278073002276 WHG domain; Region: WHG; pfam13305 1278073002277 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1278073002278 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 1278073002279 putative NADP binding site [chemical binding]; other site 1278073002280 putative substrate binding site [chemical binding]; other site 1278073002281 active site 1278073002282 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1278073002283 hypothetical protein; Validated; Region: PRK00029 1278073002284 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1278073002285 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1278073002286 C-terminal domain interface [polypeptide binding]; other site 1278073002287 GSH binding site (G-site) [chemical binding]; other site 1278073002288 dimer interface [polypeptide binding]; other site 1278073002289 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1278073002290 N-terminal domain interface [polypeptide binding]; other site 1278073002291 dimer interface [polypeptide binding]; other site 1278073002292 substrate binding pocket (H-site) [chemical binding]; other site 1278073002293 short chain dehydrogenase; Provisional; Region: PRK06197 1278073002294 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1278073002295 putative NAD(P) binding site [chemical binding]; other site 1278073002296 active site 1278073002297 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1278073002298 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1278073002299 dimerization interface [polypeptide binding]; other site 1278073002300 DPS ferroxidase diiron center [ion binding]; other site 1278073002301 ion pore; other site 1278073002302 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1278073002303 Member of the Rhodanese Homology Domain superfamily. This CD includes the putative rhodanese-like protein, Psp2, of Yersinia pestis biovar Medievalis and other similar uncharacterized proteins; Region: RHOD_PspE2; cd01521 1278073002304 active site residue [active] 1278073002305 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1278073002306 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1278073002307 DNA-binding site [nucleotide binding]; DNA binding site 1278073002308 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1278073002309 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1278073002310 homodimer interface [polypeptide binding]; other site 1278073002311 catalytic residue [active] 1278073002312 Peptidase S46; Region: Peptidase_S46; pfam10459 1278073002313 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1278073002314 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073002315 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073002316 active site 1278073002317 ATP binding site [chemical binding]; other site 1278073002318 substrate binding site [chemical binding]; other site 1278073002319 activation loop (A-loop); other site 1278073002320 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1278073002321 cyclase homology domain; Region: CHD; cd07302 1278073002322 nucleotidyl binding site; other site 1278073002323 metal binding site [ion binding]; metal-binding site 1278073002324 dimer interface [polypeptide binding]; other site 1278073002325 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1278073002326 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 1278073002327 putative C-terminal domain interface [polypeptide binding]; other site 1278073002328 putative dimer interface [polypeptide binding]; other site 1278073002329 putative GSH binding site (G-site) [chemical binding]; other site 1278073002330 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 1278073002331 putative substrate binding pocket (H-site) [chemical binding]; other site 1278073002332 putative N-terminal domain interface [polypeptide binding]; other site 1278073002333 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1278073002334 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1278073002335 putative metal binding site; other site 1278073002336 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1278073002337 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 1278073002338 Protein required for attachment to host cells; Region: Host_attach; pfam10116 1278073002339 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073002340 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1278073002341 active site 1278073002342 ATP binding site [chemical binding]; other site 1278073002343 substrate binding site [chemical binding]; other site 1278073002344 activation loop (A-loop); other site 1278073002345 PEGA domain; Region: PEGA; pfam08308 1278073002346 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 1278073002347 phosphopeptide binding site; other site 1278073002348 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 1278073002349 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1278073002350 Putative esterase; Region: Esterase; pfam00756 1278073002351 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 1278073002352 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1278073002353 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073002354 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073002355 active site 1278073002356 ATP binding site [chemical binding]; other site 1278073002357 substrate binding site [chemical binding]; other site 1278073002358 activation loop (A-loop); other site 1278073002359 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 1278073002360 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1278073002361 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1278073002362 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 1278073002363 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1278073002364 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 1278073002365 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 1278073002366 generic binding surface I; other site 1278073002367 generic binding surface II; other site 1278073002368 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 1278073002369 Lamin Tail Domain; Region: LTD; pfam00932 1278073002370 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1278073002371 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1278073002372 putative active site [active] 1278073002373 putative metal binding site [ion binding]; other site 1278073002374 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073002375 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073002376 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073002377 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073002378 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073002379 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073002380 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073002381 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073002382 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073002383 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073002384 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073002385 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073002386 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073002387 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073002388 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073002389 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073002390 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073002391 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073002392 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073002393 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073002394 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073002395 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073002396 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073002397 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073002398 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073002399 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073002400 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073002401 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073002402 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 1278073002403 Putative esterase; Region: Esterase; pfam00756 1278073002404 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1278073002405 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073002406 TIGR01777 family protein; Region: yfcH 1278073002407 NAD(P) binding site [chemical binding]; other site 1278073002408 active site 1278073002409 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1278073002410 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1278073002411 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1278073002412 substrate binding pocket [chemical binding]; other site 1278073002413 chain length determination region; other site 1278073002414 substrate-Mg2+ binding site; other site 1278073002415 catalytic residues [active] 1278073002416 aspartate-rich region 1; other site 1278073002417 active site lid residues [active] 1278073002418 aspartate-rich region 2; other site 1278073002419 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1278073002420 phytoene desaturase; Region: crtI_fam; TIGR02734 1278073002421 RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678 1278073002422 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1278073002423 active site lid residues [active] 1278073002424 substrate binding pocket [chemical binding]; other site 1278073002425 catalytic residues [active] 1278073002426 substrate-Mg2+ binding site; other site 1278073002427 aspartate-rich region 1; other site 1278073002428 aspartate-rich region 2; other site 1278073002429 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1278073002430 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 1278073002431 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 1278073002432 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1278073002433 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 1278073002434 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 1278073002435 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551 1278073002436 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1278073002437 putative acyl-acceptor binding pocket; other site 1278073002438 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1278073002439 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1278073002440 DNA binding residues [nucleotide binding] 1278073002441 B12 binding domain; Region: B12-binding_2; cl03653 1278073002442 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065 1278073002443 B12 binding site [chemical binding]; other site 1278073002444 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1278073002445 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1278073002446 DNA binding residues [nucleotide binding] 1278073002447 B12 binding domain; Region: B12-binding_2; pfam02607 1278073002448 B12 binding domain; Region: B12-binding; pfam02310 1278073002449 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 1278073002450 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073002451 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073002452 active site 1278073002453 ATP binding site [chemical binding]; other site 1278073002454 substrate binding site [chemical binding]; other site 1278073002455 activation loop (A-loop); other site 1278073002456 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1278073002457 AAA ATPase domain; Region: AAA_16; pfam13191 1278073002458 PEGA domain; Region: PEGA; pfam08308 1278073002459 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1278073002460 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1278073002461 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1278073002462 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1278073002463 phosphopeptide binding site; other site 1278073002464 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1278073002465 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073002466 Walker A motif; other site 1278073002467 ATP binding site [chemical binding]; other site 1278073002468 Walker B motif; other site 1278073002469 arginine finger; other site 1278073002470 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1278073002471 Protein of unknown function (DUF690); Region: DUF690; cl04939 1278073002472 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1278073002473 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1278073002474 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1278073002475 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1278073002476 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 1278073002477 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1278073002478 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1278073002479 tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238 1278073002480 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1278073002481 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1278073002482 catalytic residue [active] 1278073002483 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1278073002484 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1278073002485 protein binding site [polypeptide binding]; other site 1278073002486 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1278073002487 Active site serine [active] 1278073002488 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1278073002489 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1278073002490 putative NAD(P) binding site [chemical binding]; other site 1278073002491 putative active site [active] 1278073002492 FAD binding domain; Region: FAD_binding_3; pfam01494 1278073002493 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1278073002494 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1278073002495 kynureninase; Region: kynureninase; TIGR01814 1278073002496 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1278073002497 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1278073002498 catalytic residue [active] 1278073002499 active site 1278073002500 Amidohydrolase; Region: Amidohydro_2; pfam04909 1278073002501 3-hydroxyanthranilic acid dioxygenase; Region: 3-HAO; cl17399 1278073002502 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1278073002503 homotrimer interaction site [polypeptide binding]; other site 1278073002504 putative active site [active] 1278073002505 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1278073002506 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 1278073002507 NAD binding site [chemical binding]; other site 1278073002508 catalytic residues [active] 1278073002509 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1278073002510 dimer interface [polypeptide binding]; other site 1278073002511 conserved gate region; other site 1278073002512 putative PBP binding loops; other site 1278073002513 ABC-ATPase subunit interface; other site 1278073002514 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1278073002515 dimer interface [polypeptide binding]; other site 1278073002516 conserved gate region; other site 1278073002517 putative PBP binding loops; other site 1278073002518 ABC-ATPase subunit interface; other site 1278073002519 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1278073002520 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1278073002521 Walker A/P-loop; other site 1278073002522 ATP binding site [chemical binding]; other site 1278073002523 Q-loop/lid; other site 1278073002524 ABC transporter signature motif; other site 1278073002525 Walker B; other site 1278073002526 D-loop; other site 1278073002527 H-loop/switch region; other site 1278073002528 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; cl15413 1278073002529 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1278073002530 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073002531 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073002532 ATP binding site [chemical binding]; other site 1278073002533 Mg2+ binding site [ion binding]; other site 1278073002534 G-X-G motif; other site 1278073002535 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1278073002536 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073002537 NAD(P) binding site [chemical binding]; other site 1278073002538 active site 1278073002539 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 1278073002540 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1278073002541 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 1278073002542 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1278073002543 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 1278073002544 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073002545 dimer interface [polypeptide binding]; other site 1278073002546 phosphorylation site [posttranslational modification] 1278073002547 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073002548 ATP binding site [chemical binding]; other site 1278073002549 Mg2+ binding site [ion binding]; other site 1278073002550 G-X-G motif; other site 1278073002551 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073002552 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073002553 active site 1278073002554 ATP binding site [chemical binding]; other site 1278073002555 substrate binding site [chemical binding]; other site 1278073002556 activation loop (A-loop); other site 1278073002557 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073002558 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073002559 active site 1278073002560 ATP binding site [chemical binding]; other site 1278073002561 substrate binding site [chemical binding]; other site 1278073002562 activation loop (A-loop); other site 1278073002563 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1278073002564 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1278073002565 phosphopeptide binding site; other site 1278073002566 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1278073002567 PAS fold; Region: PAS_3; pfam08447 1278073002568 putative active site [active] 1278073002569 heme pocket [chemical binding]; other site 1278073002570 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1278073002571 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1278073002572 putative active site [active] 1278073002573 heme pocket [chemical binding]; other site 1278073002574 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073002575 dimer interface [polypeptide binding]; other site 1278073002576 phosphorylation site [posttranslational modification] 1278073002577 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073002578 ATP binding site [chemical binding]; other site 1278073002579 Mg2+ binding site [ion binding]; other site 1278073002580 G-X-G motif; other site 1278073002581 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1278073002582 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073002583 active site 1278073002584 phosphorylation site [posttranslational modification] 1278073002585 intermolecular recognition site; other site 1278073002586 dimerization interface [polypeptide binding]; other site 1278073002587 OPT oligopeptide transporter protein; Region: OPT; cl14607 1278073002588 OPT oligopeptide transporter protein; Region: OPT; cl14607 1278073002589 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073002590 active site 1278073002591 ATP binding site [chemical binding]; other site 1278073002592 substrate binding site [chemical binding]; other site 1278073002593 activation loop (A-loop); other site 1278073002594 AAA ATPase domain; Region: AAA_16; pfam13191 1278073002595 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1278073002596 Protein of unknown function (DUF1428); Region: DUF1428; pfam07237 1278073002597 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1278073002598 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1278073002599 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1278073002600 protein binding site [polypeptide binding]; other site 1278073002601 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136 1278073002602 protein binding site [polypeptide binding]; other site 1278073002603 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073002604 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073002605 active site 1278073002606 phosphorylation site [posttranslational modification] 1278073002607 intermolecular recognition site; other site 1278073002608 dimerization interface [polypeptide binding]; other site 1278073002609 Predicted integral membrane protein [Function unknown]; Region: COG0392 1278073002610 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 1278073002611 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1278073002612 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073002613 active site 1278073002614 phosphorylation site [posttranslational modification] 1278073002615 intermolecular recognition site; other site 1278073002616 dimerization interface [polypeptide binding]; other site 1278073002617 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073002618 Walker A motif; other site 1278073002619 ATP binding site [chemical binding]; other site 1278073002620 Walker B motif; other site 1278073002621 arginine finger; other site 1278073002622 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1278073002623 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073002624 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1278073002625 dimerization interface [polypeptide binding]; other site 1278073002626 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073002627 dimer interface [polypeptide binding]; other site 1278073002628 phosphorylation site [posttranslational modification] 1278073002629 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073002630 ATP binding site [chemical binding]; other site 1278073002631 Mg2+ binding site [ion binding]; other site 1278073002632 G-X-G motif; other site 1278073002633 Stigma-specific protein, Stig1; Region: Stig1; pfam04885 1278073002634 Stigma-specific protein, Stig1; Region: Stig1; pfam04885 1278073002635 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 1278073002636 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1278073002637 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1278073002638 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 1278073002639 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 1278073002640 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 1278073002641 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 1278073002642 TPR repeat; Region: TPR_11; pfam13414 1278073002643 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073002644 TPR motif; other site 1278073002645 binding surface 1278073002646 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1278073002647 cobyric acid synthase; Provisional; Region: PRK00784 1278073002648 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1278073002649 catalytic triad [active] 1278073002650 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1278073002651 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1278073002652 intersubunit interface [polypeptide binding]; other site 1278073002653 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1278073002654 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073002655 Walker A/P-loop; other site 1278073002656 ATP binding site [chemical binding]; other site 1278073002657 Q-loop/lid; other site 1278073002658 ABC transporter signature motif; other site 1278073002659 Walker B; other site 1278073002660 D-loop; other site 1278073002661 H-loop/switch region; other site 1278073002662 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1278073002663 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1278073002664 ABC-ATPase subunit interface; other site 1278073002665 dimer interface [polypeptide binding]; other site 1278073002666 putative PBP binding regions; other site 1278073002667 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1278073002668 catalytic core [active] 1278073002669 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1278073002670 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1278073002671 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1278073002672 putative dimer interface [polypeptide binding]; other site 1278073002673 active site pocket [active] 1278073002674 putative cataytic base [active] 1278073002675 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 1278073002676 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1278073002677 MarR family; Region: MarR_2; cl17246 1278073002678 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1278073002679 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1278073002680 HlyD family secretion protein; Region: HlyD_3; pfam13437 1278073002681 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1278073002682 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1278073002683 putative substrate translocation pore; other site 1278073002684 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 1278073002685 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073002686 binding surface 1278073002687 TPR repeat; Region: TPR_11; pfam13414 1278073002688 TPR motif; other site 1278073002689 CHAT domain; Region: CHAT; cl17868 1278073002690 Cupin-like domain; Region: Cupin_8; pfam13621 1278073002691 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1278073002692 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073002693 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1278073002694 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 1278073002695 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073002696 binding surface 1278073002697 TPR motif; other site 1278073002698 TPR repeat; Region: TPR_11; pfam13414 1278073002699 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1278073002700 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 1278073002701 active site 1278073002702 acyl-activating enzyme (AAE) consensus motif; other site 1278073002703 putative CoA binding site [chemical binding]; other site 1278073002704 AMP binding site [chemical binding]; other site 1278073002705 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 1278073002706 dimerization interface [polypeptide binding]; other site 1278073002707 DNA binding residues [nucleotide binding] 1278073002708 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1278073002709 G1 box; other site 1278073002710 GTP/Mg2+ binding site [chemical binding]; other site 1278073002711 G2 box; other site 1278073002712 Switch I region; other site 1278073002713 G3 box; other site 1278073002714 Switch II region; other site 1278073002715 G4 box; other site 1278073002716 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 1278073002717 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1278073002718 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1278073002719 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1278073002720 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1278073002721 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1278073002722 motif II; other site 1278073002723 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1278073002724 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1278073002725 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1278073002726 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1278073002727 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1278073002728 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1278073002729 putative active site [active] 1278073002730 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1278073002731 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1278073002732 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1278073002733 PAN domain; Region: PAN_4; pfam14295 1278073002734 putative binding site; other site 1278073002735 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1278073002736 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1278073002737 putative acyl-acceptor binding pocket; other site 1278073002738 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1278073002739 exonuclease subunit SbcD; Provisional; Region: PRK10966 1278073002740 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1278073002741 active site 1278073002742 metal binding site [ion binding]; metal-binding site 1278073002743 DNA binding site [nucleotide binding] 1278073002744 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1278073002745 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073002746 Walker A/P-loop; other site 1278073002747 ATP binding site [chemical binding]; other site 1278073002748 Q-loop/lid; other site 1278073002749 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073002750 ABC transporter signature motif; other site 1278073002751 Walker B; other site 1278073002752 D-loop; other site 1278073002753 H-loop/switch region; other site 1278073002754 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073002755 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073002756 active site 1278073002757 ATP binding site [chemical binding]; other site 1278073002758 substrate binding site [chemical binding]; other site 1278073002759 activation loop (A-loop); other site 1278073002760 Myxococcus xanthus paralogous domain TIGR02266; Region: gmx_TIGR02266 1278073002761 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241 1278073002762 putative active site [active] 1278073002763 Zn binding site [ion binding]; other site 1278073002764 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1278073002765 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1278073002766 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1278073002767 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1278073002768 dimerization interface [polypeptide binding]; other site 1278073002769 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073002770 dimer interface [polypeptide binding]; other site 1278073002771 phosphorylation site [posttranslational modification] 1278073002772 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073002773 ATP binding site [chemical binding]; other site 1278073002774 G-X-G motif; other site 1278073002775 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1278073002776 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073002777 active site 1278073002778 phosphorylation site [posttranslational modification] 1278073002779 intermolecular recognition site; other site 1278073002780 dimerization interface [polypeptide binding]; other site 1278073002781 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073002782 Walker B motif; other site 1278073002783 arginine finger; other site 1278073002784 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1278073002785 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1278073002786 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1278073002787 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1278073002788 dimer interface [polypeptide binding]; other site 1278073002789 conserved gate region; other site 1278073002790 ABC-ATPase subunit interface; other site 1278073002791 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1278073002792 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1278073002793 Walker A/P-loop; other site 1278073002794 ATP binding site [chemical binding]; other site 1278073002795 Q-loop/lid; other site 1278073002796 ABC transporter signature motif; other site 1278073002797 Walker B; other site 1278073002798 D-loop; other site 1278073002799 H-loop/switch region; other site 1278073002800 NIL domain; Region: NIL; pfam09383 1278073002801 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1278073002802 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1278073002803 dimer interface [polypeptide binding]; other site 1278073002804 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1278073002805 catalytic residue [active] 1278073002806 cystathionine beta-lyase; Provisional; Region: PRK07671 1278073002807 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1278073002808 homodimer interface [polypeptide binding]; other site 1278073002809 substrate-cofactor binding pocket; other site 1278073002810 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1278073002811 catalytic residue [active] 1278073002812 cystathionine gamma-synthase; Reviewed; Region: PRK08247 1278073002813 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1278073002814 homodimer interface [polypeptide binding]; other site 1278073002815 substrate-cofactor binding pocket; other site 1278073002816 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1278073002817 catalytic residue [active] 1278073002818 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1278073002819 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 1278073002820 nucleotide binding site [chemical binding]; other site 1278073002821 substrate binding site [chemical binding]; other site 1278073002822 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1278073002823 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1278073002824 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1278073002825 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1278073002826 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1278073002827 structural tetrad; other site 1278073002828 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1278073002829 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 1278073002830 endonuclease subunit; Provisional; Region: 46; PHA02562 1278073002831 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1278073002832 structural tetrad; other site 1278073002833 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1278073002834 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 1278073002835 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1278073002836 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073002837 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1278073002838 DNA binding residues [nucleotide binding] 1278073002839 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 1278073002840 GIY-YIG motif/motif A; other site 1278073002841 YHS domain; Region: YHS; pfam04945 1278073002842 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1278073002843 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1278073002844 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1278073002845 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1278073002846 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1278073002847 iron-sulfur cluster [ion binding]; other site 1278073002848 [2Fe-2S] cluster binding site [ion binding]; other site 1278073002849 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1278073002850 hydrophobic ligand binding site; other site 1278073002851 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1278073002852 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1278073002853 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1278073002854 Outer membrane efflux protein; Region: OEP; pfam02321 1278073002855 Outer membrane efflux protein; Region: OEP; pfam02321 1278073002856 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1278073002857 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1278073002858 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1278073002859 amidase catalytic site [active] 1278073002860 Zn binding residues [ion binding]; other site 1278073002861 substrate binding site [chemical binding]; other site 1278073002862 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1278073002863 HlyD family secretion protein; Region: HlyD_3; pfam13437 1278073002864 Outer membrane efflux protein; Region: OEP; pfam02321 1278073002865 Outer membrane efflux protein; Region: OEP; pfam02321 1278073002866 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1278073002867 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1278073002868 dimer interface [polypeptide binding]; other site 1278073002869 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1278073002870 catalytic residue [active] 1278073002871 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1278073002872 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073002873 active site 1278073002874 phosphorylation site [posttranslational modification] 1278073002875 intermolecular recognition site; other site 1278073002876 dimerization interface [polypeptide binding]; other site 1278073002877 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1278073002878 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073002879 dimer interface [polypeptide binding]; other site 1278073002880 phosphorylation site [posttranslational modification] 1278073002881 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073002882 ATP binding site [chemical binding]; other site 1278073002883 Mg2+ binding site [ion binding]; other site 1278073002884 G-X-G motif; other site 1278073002885 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 1278073002886 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1278073002887 ATP binding site [chemical binding]; other site 1278073002888 putative Mg++ binding site [ion binding]; other site 1278073002889 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1278073002890 nucleotide binding region [chemical binding]; other site 1278073002891 ATP-binding site [chemical binding]; other site 1278073002892 DEAD/H associated; Region: DEAD_assoc; pfam08494 1278073002893 Protein of unknown function (DUF420); Region: DUF420; pfam04238 1278073002894 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 1278073002895 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 1278073002896 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 1278073002897 FG-GAP repeat; Region: FG-GAP; cl15299 1278073002898 Family description; Region: VCBS; pfam13517 1278073002899 FG-GAP repeat; Region: FG-GAP; cl15299 1278073002900 Family description; Region: VCBS; pfam13517 1278073002901 Family description; Region: VCBS; pfam13517 1278073002902 EamA-like transporter family; Region: EamA; pfam00892 1278073002903 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1278073002904 EamA-like transporter family; Region: EamA; pfam00892 1278073002905 LigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: LigD_Pol_like; cd04861 1278073002906 nucleotide binding site [chemical binding]; other site 1278073002907 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1278073002908 dinuclear metal binding motif [ion binding]; other site 1278073002909 formiminoglutamate deiminase; Region: hutF; TIGR02022 1278073002910 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 1278073002911 active site 1278073002912 acetylornithine deacetylase (ArgE); Region: AcOrn-deacetyl; TIGR01892 1278073002913 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1278073002914 metal binding site [ion binding]; metal-binding site 1278073002915 putative dimer interface [polypeptide binding]; other site 1278073002916 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1278073002917 Protein of unknown function (DUF2167); Region: DUF2167; pfam09935 1278073002918 transcription-repair coupling factor (mfd); Region: mfd; TIGR00580 1278073002919 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 1278073002920 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1278073002921 ATP binding site [chemical binding]; other site 1278073002922 putative Mg++ binding site [ion binding]; other site 1278073002923 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1278073002924 nucleotide binding region [chemical binding]; other site 1278073002925 ATP-binding site [chemical binding]; other site 1278073002926 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1278073002927 PAS domain; Region: PAS; smart00091 1278073002928 PAS fold; Region: PAS_4; pfam08448 1278073002929 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073002930 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073002931 dimer interface [polypeptide binding]; other site 1278073002932 phosphorylation site [posttranslational modification] 1278073002933 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073002934 ATP binding site [chemical binding]; other site 1278073002935 Mg2+ binding site [ion binding]; other site 1278073002936 G-X-G motif; other site 1278073002937 Cytochrome c; Region: Cytochrom_C; pfam00034 1278073002938 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1278073002939 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1278073002940 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073002941 S-adenosylmethionine binding site [chemical binding]; other site 1278073002942 Chain length determinant protein; Region: Wzz; cl15801 1278073002943 chain length determinant protein EpsF; Region: EpsF; TIGR03017 1278073002944 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1278073002945 Chain length determinant protein; Region: Wzz; cl15801 1278073002946 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1278073002947 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1278073002948 Magnesium ion binding site [ion binding]; other site 1278073002949 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1278073002950 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 1278073002951 putative ADP-binding pocket [chemical binding]; other site 1278073002952 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1278073002953 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1278073002954 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1278073002955 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1278073002956 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1278073002957 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1278073002958 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1278073002959 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1278073002960 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1278073002961 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073002962 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073002963 active site 1278073002964 ATP binding site [chemical binding]; other site 1278073002965 substrate binding site [chemical binding]; other site 1278073002966 activation loop (A-loop); other site 1278073002967 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1278073002968 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1278073002969 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1278073002970 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1278073002971 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073002972 S-adenosylmethionine binding site [chemical binding]; other site 1278073002973 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1278073002974 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1278073002975 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1278073002976 Probable Catalytic site; other site 1278073002977 metal-binding site 1278073002978 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1278073002979 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1278073002980 active site 1278073002981 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1278073002982 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1278073002983 nucleotide binding site [chemical binding]; other site 1278073002984 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1278073002985 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1278073002986 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1278073002987 active site 1278073002988 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1278073002989 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1278073002990 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1278073002991 Mg++ binding site [ion binding]; other site 1278073002992 putative catalytic motif [active] 1278073002993 substrate binding site [chemical binding]; other site 1278073002994 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1278073002995 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1278073002996 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1278073002997 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1278073002998 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1278073002999 O-Antigen ligase; Region: Wzy_C; pfam04932 1278073003000 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 1278073003001 putative deacylase active site [active] 1278073003002 succinylarginine dihydrolase; Provisional; Region: PRK13281 1278073003003 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1278073003004 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1278073003005 putative acyl-acceptor binding pocket; other site 1278073003006 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1278073003007 OstA-like protein; Region: OstA; cl00844 1278073003008 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1278073003009 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1278073003010 Walker A/P-loop; other site 1278073003011 ATP binding site [chemical binding]; other site 1278073003012 Q-loop/lid; other site 1278073003013 ABC transporter signature motif; other site 1278073003014 Walker B; other site 1278073003015 D-loop; other site 1278073003016 H-loop/switch region; other site 1278073003017 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1278073003018 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1278073003019 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1278073003020 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1278073003021 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1278073003022 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1278073003023 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1278073003024 30S subunit binding site; other site 1278073003025 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1278073003026 active site 1278073003027 phosphorylation site [posttranslational modification] 1278073003028 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1278073003029 putative active site [active] 1278073003030 dimerization interface [polypeptide binding]; other site 1278073003031 putative tRNAtyr binding site [nucleotide binding]; other site 1278073003032 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1278073003033 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1278073003034 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1278073003035 dimer interface [polypeptide binding]; other site 1278073003036 ssDNA binding site [nucleotide binding]; other site 1278073003037 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1278073003038 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1278073003039 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 1278073003040 Iron-sulfur protein interface; other site 1278073003041 proximal heme binding site [chemical binding]; other site 1278073003042 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1278073003043 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1278073003044 dimerization interface [polypeptide binding]; other site 1278073003045 domain crossover interface; other site 1278073003046 redox-dependent activation switch; other site 1278073003047 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1278073003048 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 1278073003049 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1278073003050 NAD binding site [chemical binding]; other site 1278073003051 Phe binding site; other site 1278073003052 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 1278073003053 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1278073003054 active site 1278073003055 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 1278073003056 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1278073003057 G1 box; other site 1278073003058 GTP/Mg2+ binding site [chemical binding]; other site 1278073003059 G2 box; other site 1278073003060 Switch I region; other site 1278073003061 G3 box; other site 1278073003062 Switch II region; other site 1278073003063 G4 box; other site 1278073003064 G5 box; other site 1278073003065 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 1278073003066 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 1278073003067 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 1278073003068 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 1278073003069 PAS domain; Region: PAS; smart00091 1278073003070 putative active site [active] 1278073003071 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1278073003072 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1278073003073 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073003074 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073003075 dimer interface [polypeptide binding]; other site 1278073003076 phosphorylation site [posttranslational modification] 1278073003077 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073003078 ATP binding site [chemical binding]; other site 1278073003079 Mg2+ binding site [ion binding]; other site 1278073003080 G-X-G motif; other site 1278073003081 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1278073003082 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073003083 active site 1278073003084 phosphorylation site [posttranslational modification] 1278073003085 intermolecular recognition site; other site 1278073003086 dimerization interface [polypeptide binding]; other site 1278073003087 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073003088 Walker A motif; other site 1278073003089 ATP binding site [chemical binding]; other site 1278073003090 Walker B motif; other site 1278073003091 arginine finger; other site 1278073003092 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1278073003093 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1278073003094 Coenzyme A binding pocket [chemical binding]; other site 1278073003095 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1278073003096 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1278073003097 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1278073003098 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1278073003099 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1278073003100 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1278073003101 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1278073003102 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1278073003103 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1278073003104 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1278073003105 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1278073003106 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1278073003107 SLBB domain; Region: SLBB; pfam10531 1278073003108 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 1278073003109 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 1278073003110 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1278073003111 putative dimer interface [polypeptide binding]; other site 1278073003112 [2Fe-2S] cluster binding site [ion binding]; other site 1278073003113 Myxococcus xanthus paralogous domain TIGR02266; Region: gmx_TIGR02266 1278073003114 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1278073003115 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073003116 active site 1278073003117 phosphorylation site [posttranslational modification] 1278073003118 intermolecular recognition site; other site 1278073003119 dimerization interface [polypeptide binding]; other site 1278073003120 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073003121 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073003122 active site 1278073003123 ATP binding site [chemical binding]; other site 1278073003124 substrate binding site [chemical binding]; other site 1278073003125 activation loop (A-loop); other site 1278073003126 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1278073003127 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 1278073003128 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1278073003129 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1278073003130 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1278073003131 motif II; other site 1278073003132 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1278073003133 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 1278073003134 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1278073003135 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1278073003136 putative dimer interface [polypeptide binding]; other site 1278073003137 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1278073003138 DNA binding residues [nucleotide binding] 1278073003139 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073003140 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073003141 active site 1278073003142 phosphorylation site [posttranslational modification] 1278073003143 intermolecular recognition site; other site 1278073003144 dimerization interface [polypeptide binding]; other site 1278073003145 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1278073003146 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1278073003147 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1278073003148 CTP synthetase; Validated; Region: pyrG; PRK05380 1278073003149 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1278073003150 Catalytic site [active] 1278073003151 active site 1278073003152 UTP binding site [chemical binding]; other site 1278073003153 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1278073003154 active site 1278073003155 putative oxyanion hole; other site 1278073003156 catalytic triad [active] 1278073003157 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1278073003158 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 1278073003159 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 1278073003160 Walker A/P-loop; other site 1278073003161 ATP binding site [chemical binding]; other site 1278073003162 Q-loop/lid; other site 1278073003163 ABC transporter signature motif; other site 1278073003164 Walker B; other site 1278073003165 D-loop; other site 1278073003166 H-loop/switch region; other site 1278073003167 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1278073003168 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1278073003169 active site 1278073003170 catalytic tetrad [active] 1278073003171 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1278073003172 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1278073003173 Ligand binding site; other site 1278073003174 oligomer interface; other site 1278073003175 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1278073003176 active site 1278073003177 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 1278073003178 homodimer interface [polypeptide binding]; other site 1278073003179 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1278073003180 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1278073003181 active site 1278073003182 amidophosphoribosyltransferase; Provisional; Region: PRK09123 1278073003183 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1278073003184 active site 1278073003185 tetramer interface [polypeptide binding]; other site 1278073003186 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1278073003187 active site 1278073003188 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 1278073003189 enoyl-CoA hydratase; Provisional; Region: PRK06563 1278073003190 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1278073003191 substrate binding site [chemical binding]; other site 1278073003192 oxyanion hole (OAH) forming residues; other site 1278073003193 trimer interface [polypeptide binding]; other site 1278073003194 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 1278073003195 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1278073003196 HSP70 interaction site [polypeptide binding]; other site 1278073003197 TPR repeat; Region: TPR_11; pfam13414 1278073003198 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073003199 binding surface 1278073003200 TPR motif; other site 1278073003201 hypothetical protein; Provisional; Region: PRK10621 1278073003202 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1278073003203 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 1278073003204 putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK05641 1278073003205 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1278073003206 carboxyltransferase (CT) interaction site; other site 1278073003207 biotinylation site [posttranslational modification]; other site 1278073003208 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1278073003209 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1278073003210 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1278073003211 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1278073003212 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 1278073003213 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1278073003214 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1278073003215 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 1278073003216 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 1278073003217 active site 1278073003218 putative substrate binding region [chemical binding]; other site 1278073003219 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1278073003220 methionine S-methyltransferase; Region: PLN02672 1278073003221 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1278073003222 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1278073003223 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1278073003224 catalytic residue [active] 1278073003225 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1278073003226 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1278073003227 homodimer interface [polypeptide binding]; other site 1278073003228 catalytic residue [active] 1278073003229 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1278073003230 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073003231 Walker A/P-loop; other site 1278073003232 ATP binding site [chemical binding]; other site 1278073003233 Q-loop/lid; other site 1278073003234 ABC transporter signature motif; other site 1278073003235 Walker B; other site 1278073003236 D-loop; other site 1278073003237 H-loop/switch region; other site 1278073003238 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073003239 S-adenosylmethionine binding site [chemical binding]; other site 1278073003240 PRMT5 arginine-N-methyltransferase; Region: PRMT5; cl17640 1278073003241 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1278073003242 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 1278073003243 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 1278073003244 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1278073003245 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073003246 active site 1278073003247 phosphorylation site [posttranslational modification] 1278073003248 intermolecular recognition site; other site 1278073003249 dimerization interface [polypeptide binding]; other site 1278073003250 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073003251 Walker A motif; other site 1278073003252 ATP binding site [chemical binding]; other site 1278073003253 Walker B motif; other site 1278073003254 arginine finger; other site 1278073003255 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1278073003256 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073003257 dimer interface [polypeptide binding]; other site 1278073003258 phosphorylation site [posttranslational modification] 1278073003259 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073003260 ATP binding site [chemical binding]; other site 1278073003261 Mg2+ binding site [ion binding]; other site 1278073003262 G-X-G motif; other site 1278073003263 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1278073003264 RDD family; Region: RDD; pfam06271 1278073003265 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1278073003266 RNA methyltransferase, RsmE family; Region: TIGR00046 1278073003267 Protein of unknown function (DUF962); Region: DUF962; cl01879 1278073003268 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1278073003269 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1278073003270 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1278073003271 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 1278073003272 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 1278073003273 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1278073003274 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073003275 S-adenosylmethionine binding site [chemical binding]; other site 1278073003276 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 1278073003277 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 1278073003278 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1278073003279 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1278073003280 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1278073003281 dimerization interface [polypeptide binding]; other site 1278073003282 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1278073003283 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1278073003284 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1278073003285 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1278073003286 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1278073003287 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1278073003288 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 1278073003289 HemN C-terminal domain; Region: HemN_C; pfam06969 1278073003290 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1278073003291 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 1278073003292 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073003293 binding surface 1278073003294 TPR motif; other site 1278073003295 TadE-like protein; Region: TadE; pfam07811 1278073003296 TadE-like protein; Region: TadE; pfam07811 1278073003297 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1278073003298 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 1278073003299 putative ligand binding site [chemical binding]; other site 1278073003300 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 1278073003301 Transcriptional regulator; Region: Rrf2; pfam02082 1278073003302 Transcriptional regulator; Region: Rrf2; cl17282 1278073003303 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1278073003304 putative ABC transporter; Region: ycf24; CHL00085 1278073003305 sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131 1278073003306 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1278073003307 Walker A/P-loop; other site 1278073003308 ATP binding site [chemical binding]; other site 1278073003309 Q-loop/lid; other site 1278073003310 ABC transporter signature motif; other site 1278073003311 Walker B; other site 1278073003312 D-loop; other site 1278073003313 H-loop/switch region; other site 1278073003314 FeS assembly protein SufD; Region: sufD; TIGR01981 1278073003315 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 1278073003316 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1278073003317 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1278073003318 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1278073003319 catalytic residue [active] 1278073003320 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1278073003321 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1278073003322 trimerization site [polypeptide binding]; other site 1278073003323 active site 1278073003324 probable FeS assembly SUF system protein SufT; Region: FeS_long_SufT; TIGR03406 1278073003325 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1278073003326 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1278073003327 proposed catalytic triad [active] 1278073003328 conserved cys residue [active] 1278073003329 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 1278073003330 catalytic nucleophile [active] 1278073003331 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1278073003332 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1278073003333 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1278073003334 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1278073003335 Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089 1278073003336 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 1278073003337 Domain of Unknown Function with PDB structure (DUF3858); Region: DUF3858; pfam12970 1278073003338 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073003339 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073003340 active site 1278073003341 ATP binding site [chemical binding]; other site 1278073003342 substrate binding site [chemical binding]; other site 1278073003343 activation loop (A-loop); other site 1278073003344 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1278073003345 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1278073003346 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073003347 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073003348 dimer interface [polypeptide binding]; other site 1278073003349 phosphorylation site [posttranslational modification] 1278073003350 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073003351 ATP binding site [chemical binding]; other site 1278073003352 Mg2+ binding site [ion binding]; other site 1278073003353 G-X-G motif; other site 1278073003354 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1278073003355 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073003356 active site 1278073003357 phosphorylation site [posttranslational modification] 1278073003358 intermolecular recognition site; other site 1278073003359 dimerization interface [polypeptide binding]; other site 1278073003360 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073003361 Walker A motif; other site 1278073003362 ATP binding site [chemical binding]; other site 1278073003363 Walker B motif; other site 1278073003364 arginine finger; other site 1278073003365 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1278073003366 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39A; cd02549 1278073003367 putative active site [active] 1278073003368 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1278073003369 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1278073003370 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 1278073003371 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 1278073003372 Cutinase; Region: Cutinase; pfam01083 1278073003373 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1278073003374 active site 1278073003375 trigger factor; Region: tig; TIGR00115 1278073003376 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; pfam02675 1278073003377 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 1278073003378 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1278073003379 spermidine synthase; Provisional; Region: PRK03612 1278073003380 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073003381 S-adenosylmethionine binding site [chemical binding]; other site 1278073003382 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1278073003383 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1278073003384 Sulfatase; Region: Sulfatase; pfam00884 1278073003385 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1278073003386 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1278073003387 active site 1278073003388 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1278073003389 homotrimer interaction site [polypeptide binding]; other site 1278073003390 putative active site [active] 1278073003391 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 1278073003392 SnoaL-like domain; Region: SnoaL_3; pfam13474 1278073003393 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1278073003394 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073003395 active site 1278073003396 phosphorylation site [posttranslational modification] 1278073003397 intermolecular recognition site; other site 1278073003398 dimerization interface [polypeptide binding]; other site 1278073003399 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073003400 Walker A motif; other site 1278073003401 ATP binding site [chemical binding]; other site 1278073003402 Walker B motif; other site 1278073003403 arginine finger; other site 1278073003404 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1278073003405 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073003406 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1278073003407 dimerization interface [polypeptide binding]; other site 1278073003408 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073003409 dimer interface [polypeptide binding]; other site 1278073003410 phosphorylation site [posttranslational modification] 1278073003411 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073003412 ATP binding site [chemical binding]; other site 1278073003413 Mg2+ binding site [ion binding]; other site 1278073003414 G-X-G motif; other site 1278073003415 putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional; Region: PRK14501 1278073003416 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1278073003417 active site 1278073003418 homotetramer interface [polypeptide binding]; other site 1278073003419 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1278073003420 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1278073003421 Beta-lactamase; Region: Beta-lactamase; pfam00144 1278073003422 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073003423 TPR motif; other site 1278073003424 binding surface 1278073003425 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1278073003426 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1278073003427 TPR motif; other site 1278073003428 binding surface 1278073003429 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 1278073003430 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1278073003431 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1278073003432 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1278073003433 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 1278073003434 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 1278073003435 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1278073003436 Zn binding site [ion binding]; other site 1278073003437 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1278073003438 phosphoglyceromutase; Provisional; Region: PRK05434 1278073003439 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1278073003440 hypothetical protein; Reviewed; Region: PRK09588 1278073003441 Uncharacterized protein family UPF0027; Region: UPF0027; cl17455 1278073003442 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1278073003443 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 1278073003444 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073003445 TPR motif; other site 1278073003446 TPR repeat; Region: TPR_11; pfam13414 1278073003447 binding surface 1278073003448 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 1278073003449 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1278073003450 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073003451 active site 1278073003452 phosphorylation site [posttranslational modification] 1278073003453 intermolecular recognition site; other site 1278073003454 dimerization interface [polypeptide binding]; other site 1278073003455 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073003456 Walker A motif; other site 1278073003457 ATP binding site [chemical binding]; other site 1278073003458 Walker B motif; other site 1278073003459 arginine finger; other site 1278073003460 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1278073003461 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 1278073003462 nudix motif; other site 1278073003463 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 1278073003464 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1278073003465 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1278073003466 dimer interface [polypeptide binding]; other site 1278073003467 putative CheW interface [polypeptide binding]; other site 1278073003468 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073003469 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1278073003470 dimerization interface [polypeptide binding]; other site 1278073003471 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073003472 dimer interface [polypeptide binding]; other site 1278073003473 phosphorylation site [posttranslational modification] 1278073003474 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073003475 ATP binding site [chemical binding]; other site 1278073003476 Mg2+ binding site [ion binding]; other site 1278073003477 G-X-G motif; other site 1278073003478 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1278073003479 catalytic residue [active] 1278073003480 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1278073003481 Predicted transcriptional regulator [Transcription]; Region: COG2378 1278073003482 HTH domain; Region: HTH_11; cl17392 1278073003483 WYL domain; Region: WYL; pfam13280 1278073003484 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 1278073003485 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1278073003486 CGNR zinc finger; Region: zf-CGNR; pfam11706 1278073003487 Haemolysin-III related; Region: HlyIII; pfam03006 1278073003488 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1278073003489 DoxX-like family; Region: DoxX_2; pfam13564 1278073003490 Predicted transcriptional regulators [Transcription]; Region: COG1733 1278073003491 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1278073003492 DNA repair protein RadA; Provisional; Region: PRK11823 1278073003493 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1278073003494 Walker A motif/ATP binding site; other site 1278073003495 ATP binding site [chemical binding]; other site 1278073003496 Walker B motif; other site 1278073003497 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1278073003498 biotin synthase; Region: bioB; TIGR00433 1278073003499 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1278073003500 FeS/SAM binding site; other site 1278073003501 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1278073003502 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1278073003503 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1278073003504 substrate-cofactor binding pocket; other site 1278073003505 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1278073003506 catalytic residue [active] 1278073003507 AAA domain; Region: AAA_26; pfam13500 1278073003508 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1278073003509 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1278073003510 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1278073003511 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1278073003512 homodimer interface [polypeptide binding]; other site 1278073003513 catalytic residue [active] 1278073003514 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1278073003515 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1278073003516 ligand binding site [chemical binding]; other site 1278073003517 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073003518 TPR repeat; Region: TPR_11; pfam13414 1278073003519 binding surface 1278073003520 TPR motif; other site 1278073003521 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 1278073003522 active site 1278073003523 substrate-binding site [chemical binding]; other site 1278073003524 metal-binding site [ion binding] 1278073003525 GTP binding site [chemical binding]; other site 1278073003526 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1278073003527 TrkA-C domain; Region: TrkA_C; pfam02080 1278073003528 TrkA-C domain; Region: TrkA_C; pfam02080 1278073003529 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1278073003530 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1278073003531 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 1278073003532 active site 1278073003533 dinuclear metal binding site [ion binding]; other site 1278073003534 dimerization interface [polypeptide binding]; other site 1278073003535 Predicted acetyltransferase [General function prediction only]; Region: COG3393 1278073003536 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 1278073003537 Patatin-like phospholipase; Region: Patatin; pfam01734 1278073003538 nucleophile elbow; other site 1278073003539 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1278073003540 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 1278073003541 active site 1278073003542 HIGH motif; other site 1278073003543 nucleotide binding site [chemical binding]; other site 1278073003544 active site 1278073003545 KMSKS motif; other site 1278073003546 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1278073003547 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1278073003548 active site 1278073003549 metal binding site [ion binding]; metal-binding site 1278073003550 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 1278073003551 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1278073003552 FeS/SAM binding site; other site 1278073003553 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1278073003554 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1278073003555 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 1278073003556 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073003557 active site 1278073003558 phosphorylation site [posttranslational modification] 1278073003559 intermolecular recognition site; other site 1278073003560 dimerization interface [polypeptide binding]; other site 1278073003561 LytTr DNA-binding domain; Region: LytTR; smart00850 1278073003562 Histidine kinase; Region: His_kinase; pfam06580 1278073003563 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1278073003564 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1278073003565 C factor cell-cell signaling protein; Provisional; Region: PRK09009 1278073003566 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 1278073003567 NADP binding site [chemical binding]; other site 1278073003568 homodimer interface [polypeptide binding]; other site 1278073003569 active site 1278073003570 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 1278073003571 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1278073003572 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1278073003573 glycogen synthase; Provisional; Region: glgA; PRK00654 1278073003574 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1278073003575 ADP-binding pocket [chemical binding]; other site 1278073003576 homodimer interface [polypeptide binding]; other site 1278073003577 Protein kinase domain; Region: Pkinase; pfam00069 1278073003578 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073003579 active site 1278073003580 ATP binding site [chemical binding]; other site 1278073003581 substrate binding site [chemical binding]; other site 1278073003582 activation loop (A-loop); other site 1278073003583 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 1278073003584 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1278073003585 Domain of unknown function DUF21; Region: DUF21; pfam01595 1278073003586 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1278073003587 Transporter associated domain; Region: CorC_HlyC; smart01091 1278073003588 choice-of-anchor B domain; Region: choice_anch_B; TIGR04312 1278073003589 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1278073003590 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1278073003591 structural tetrad; other site 1278073003592 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1278073003593 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 1278073003594 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 1278073003595 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1278073003596 N-terminal plug; other site 1278073003597 ligand-binding site [chemical binding]; other site 1278073003598 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105 1278073003599 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 1278073003600 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 1278073003601 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 1278073003602 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1278073003603 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1278073003604 intersubunit interface [polypeptide binding]; other site 1278073003605 FecCD transport family; Region: FecCD; pfam01032 1278073003606 putative PBP binding regions; other site 1278073003607 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 1278073003608 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1278073003609 Walker A/P-loop; other site 1278073003610 ATP binding site [chemical binding]; other site 1278073003611 Q-loop/lid; other site 1278073003612 ABC transporter signature motif; other site 1278073003613 Walker B; other site 1278073003614 D-loop; other site 1278073003615 H-loop/switch region; other site 1278073003616 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 1278073003617 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073003618 TPR motif; other site 1278073003619 binding surface 1278073003620 TPR repeat; Region: TPR_11; pfam13414 1278073003621 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073003622 binding surface 1278073003623 TPR motif; other site 1278073003624 TPR repeat; Region: TPR_11; pfam13414 1278073003625 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073003626 binding surface 1278073003627 TPR motif; other site 1278073003628 TPR repeat; Region: TPR_11; pfam13414 1278073003629 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073003630 TPR repeat; Region: TPR_11; pfam13414 1278073003631 binding surface 1278073003632 TPR motif; other site 1278073003633 TPR repeat; Region: TPR_11; pfam13414 1278073003634 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073003635 binding surface 1278073003636 TPR motif; other site 1278073003637 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 1278073003638 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 1278073003639 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1278073003640 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1278073003641 metal ion-dependent adhesion site (MIDAS); other site 1278073003642 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1278073003643 metal ion-dependent adhesion site (MIDAS); other site 1278073003644 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1278073003645 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1278073003646 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1278073003647 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 1278073003648 DEP domain, named after Dishevelled, Egl-10, and Pleckstrin, where this domain was first discovered. The function of this domain is still not clear, but it is believed to be important for the membrane association of the signaling proteins in which it is...; Region: DEP; cl02442 1278073003649 Domain of unknown function (DUF3332); Region: DUF3332; pfam11810 1278073003650 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 1278073003651 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1278073003652 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1278073003653 phosphopeptide binding site; other site 1278073003654 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073003655 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1278073003656 Walker A motif; other site 1278073003657 ATP binding site [chemical binding]; other site 1278073003658 Walker B motif; other site 1278073003659 arginine finger; other site 1278073003660 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1278073003661 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1278073003662 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 1278073003663 active site 1278073003664 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1278073003665 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1278073003666 active site 1278073003667 Methyltransferase domain; Region: Methyltransf_18; pfam12847 1278073003668 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1278073003669 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073003670 active site 1278073003671 phosphorylation site [posttranslational modification] 1278073003672 intermolecular recognition site; other site 1278073003673 dimerization interface [polypeptide binding]; other site 1278073003674 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1278073003675 DNA binding site [nucleotide binding] 1278073003676 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073003677 dimer interface [polypeptide binding]; other site 1278073003678 phosphorylation site [posttranslational modification] 1278073003679 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073003680 ATP binding site [chemical binding]; other site 1278073003681 Mg2+ binding site [ion binding]; other site 1278073003682 G-X-G motif; other site 1278073003683 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1278073003684 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 1278073003685 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1278073003686 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1278073003687 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1278073003688 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1278073003689 H+ Antiporter protein; Region: 2A0121; TIGR00900 1278073003690 putative substrate translocation pore; other site 1278073003691 acetyl-lysine deacetylase; Provisional; Region: PRK04443 1278073003692 M20 Peptidase acetylornithine deacetylase/acetyl-lysine deacetylase; Region: M20_ArgE_LysK; cd05653 1278073003693 metal binding site [ion binding]; metal-binding site 1278073003694 putative dimer interface [polypeptide binding]; other site 1278073003695 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1278073003696 nucleotide binding site [chemical binding]; other site 1278073003697 N-acetyl-L-glutamate binding site [chemical binding]; other site 1278073003698 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073003699 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1278073003700 NAD(P) binding site [chemical binding]; other site 1278073003701 active site 1278073003702 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1278073003703 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1278073003704 Lysine biosynthesis enzyme LysX; Region: LysX_arch; TIGR02144 1278073003705 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1278073003706 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1278073003707 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1278073003708 PYR/PP interface [polypeptide binding]; other site 1278073003709 dimer interface [polypeptide binding]; other site 1278073003710 TPP binding site [chemical binding]; other site 1278073003711 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1278073003712 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1278073003713 TPP-binding site [chemical binding]; other site 1278073003714 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 1278073003715 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1278073003716 acyl-activating enzyme (AAE) consensus motif; other site 1278073003717 AMP binding site [chemical binding]; other site 1278073003718 active site 1278073003719 CoA binding site [chemical binding]; other site 1278073003720 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073003721 Condensation domain; Region: Condensation; pfam00668 1278073003722 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073003723 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073003724 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073003725 acyl-activating enzyme (AAE) consensus motif; other site 1278073003726 AMP binding site [chemical binding]; other site 1278073003727 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073003728 Condensation domain; Region: Condensation; pfam00668 1278073003729 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073003730 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073003731 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1278073003732 acyl-activating enzyme (AAE) consensus motif; other site 1278073003733 AMP binding site [chemical binding]; other site 1278073003734 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073003735 Condensation domain; Region: Condensation; pfam00668 1278073003736 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073003737 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073003738 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073003739 Condensation domain; Region: Condensation; pfam00668 1278073003740 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073003741 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073003742 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073003743 acyl-activating enzyme (AAE) consensus motif; other site 1278073003744 AMP binding site [chemical binding]; other site 1278073003745 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073003746 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1278073003747 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073003748 active site 1278073003749 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1278073003750 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1278073003751 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073003752 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1278073003753 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1278073003754 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1278073003755 HflX GTPase family; Region: HflX; cd01878 1278073003756 G1 box; other site 1278073003757 GTP/Mg2+ binding site [chemical binding]; other site 1278073003758 Switch I region; other site 1278073003759 G2 box; other site 1278073003760 G3 box; other site 1278073003761 Switch II region; other site 1278073003762 G4 box; other site 1278073003763 G5 box; other site 1278073003764 gamma-glutamyl kinase; Provisional; Region: PRK05429 1278073003765 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1278073003766 nucleotide binding site [chemical binding]; other site 1278073003767 homotetrameric interface [polypeptide binding]; other site 1278073003768 putative phosphate binding site [ion binding]; other site 1278073003769 putative allosteric binding site; other site 1278073003770 PUA domain; Region: PUA; pfam01472 1278073003771 Predicted transcriptional regulator [Transcription]; Region: COG2378 1278073003772 WYL domain; Region: WYL; pfam13280 1278073003773 WYL domain; Region: WYL; pfam13280 1278073003774 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1278073003775 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1278073003776 phosphopeptide binding site; other site 1278073003777 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1278073003778 PLD-like domain; Region: PLDc_2; pfam13091 1278073003779 putative active site [active] 1278073003780 catalytic site [active] 1278073003781 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 1278073003782 PLD-like domain; Region: PLDc_2; pfam13091 1278073003783 putative active site [active] 1278073003784 catalytic site [active] 1278073003785 aconitate hydratase; Validated; Region: PRK09277 1278073003786 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1278073003787 substrate binding site [chemical binding]; other site 1278073003788 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1278073003789 ligand binding site [chemical binding]; other site 1278073003790 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1278073003791 substrate binding site [chemical binding]; other site 1278073003792 HD domain; Region: HD_4; pfam13328 1278073003793 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1278073003794 RF-1 domain; Region: RF-1; pfam00472 1278073003795 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1278073003796 Pirin-related protein [General function prediction only]; Region: COG1741 1278073003797 Pirin; Region: Pirin; pfam02678 1278073003798 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1278073003799 metal ion-dependent adhesion site (MIDAS); other site 1278073003800 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1278073003801 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1278073003802 Walker A/P-loop; other site 1278073003803 ATP binding site [chemical binding]; other site 1278073003804 Q-loop/lid; other site 1278073003805 ABC transporter signature motif; other site 1278073003806 Walker B; other site 1278073003807 D-loop; other site 1278073003808 H-loop/switch region; other site 1278073003809 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073003810 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073003811 active site 1278073003812 phosphorylation site [posttranslational modification] 1278073003813 intermolecular recognition site; other site 1278073003814 dimerization interface [polypeptide binding]; other site 1278073003815 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1278073003816 Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin; Region: M3A_TOP; cd06455 1278073003817 active site 1278073003818 Zn binding site [ion binding]; other site 1278073003819 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1278073003820 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1278073003821 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1278073003822 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1278073003823 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 1278073003824 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1278073003825 Substrate binding site; other site 1278073003826 Mg++ binding site; other site 1278073003827 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1278073003828 active site 1278073003829 substrate binding site [chemical binding]; other site 1278073003830 CoA binding site [chemical binding]; other site 1278073003831 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1278073003832 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1278073003833 glutaminase active site [active] 1278073003834 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1278073003835 dimer interface [polypeptide binding]; other site 1278073003836 active site 1278073003837 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1278073003838 dimer interface [polypeptide binding]; other site 1278073003839 active site 1278073003840 recombinase A; Provisional; Region: recA; PRK09354 1278073003841 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1278073003842 hexamer interface [polypeptide binding]; other site 1278073003843 Walker A motif; other site 1278073003844 ATP binding site [chemical binding]; other site 1278073003845 Walker B motif; other site 1278073003846 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1278073003847 putative active site [active] 1278073003848 putative metal binding site [ion binding]; other site 1278073003849 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1278073003850 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1278073003851 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1278073003852 Coenzyme A binding pocket [chemical binding]; other site 1278073003853 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1278073003854 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1278073003855 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1278073003856 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1278073003857 RNA binding site [nucleotide binding]; other site 1278073003858 HSP90 family protein; Provisional; Region: PRK14083 1278073003859 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073003860 ATP binding site [chemical binding]; other site 1278073003861 Mg2+ binding site [ion binding]; other site 1278073003862 G-X-G motif; other site 1278073003863 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1278073003864 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1278073003865 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1278073003866 Predicted membrane protein [Function unknown]; Region: COG1289 1278073003867 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1278073003868 HEAT repeats; Region: HEAT_2; pfam13646 1278073003869 HEAT repeats; Region: HEAT_2; pfam13646 1278073003870 HEAT repeats; Region: HEAT_2; pfam13646 1278073003871 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1278073003872 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1278073003873 putative active site [active] 1278073003874 substrate binding site [chemical binding]; other site 1278073003875 putative cosubstrate binding site; other site 1278073003876 catalytic site [active] 1278073003877 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1278073003878 substrate binding site [chemical binding]; other site 1278073003879 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1278073003880 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cl00505 1278073003881 trimer interface [polypeptide binding]; other site 1278073003882 active site 1278073003883 dimer interface [polypeptide binding]; other site 1278073003884 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1278073003885 NusB family; Region: NusB; pfam01029 1278073003886 putative RNA binding site [nucleotide binding]; other site 1278073003887 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 1278073003888 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1278073003889 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1278073003890 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1278073003891 dimerization interface [polypeptide binding]; other site 1278073003892 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 1278073003893 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1278073003894 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1278073003895 classical (c) SDRs; Region: SDR_c; cd05233 1278073003896 NAD(P) binding site [chemical binding]; other site 1278073003897 active site 1278073003898 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1278073003899 transaminase; Validated; Region: PRK07324 1278073003900 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1278073003901 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1278073003902 homodimer interface [polypeptide binding]; other site 1278073003903 catalytic residue [active] 1278073003904 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1278073003905 Protein phosphatase 2C; Region: PP2C; pfam00481 1278073003906 active site 1278073003907 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1278073003908 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1278073003909 dimerization interface [polypeptide binding]; other site 1278073003910 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1278073003911 dimer interface [polypeptide binding]; other site 1278073003912 putative CheW interface [polypeptide binding]; other site 1278073003913 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1278073003914 classical (c) SDRs; Region: SDR_c; cd05233 1278073003915 NAD(P) binding site [chemical binding]; other site 1278073003916 active site 1278073003917 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1278073003918 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1278073003919 active site 1278073003920 Peptidase M3-like family, a zincin metallopeptidase, includes M3 and M32 families; Region: M3_like; cd06258 1278073003921 active site 1278073003922 Zn binding site [ion binding]; other site 1278073003923 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1278073003924 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1278073003925 active site 1278073003926 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 1278073003927 Protein of unknown function (DUF3308); Region: DUF3308; cl14675 1278073003928 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1278073003929 active site 1278073003930 tetramer interface; other site 1278073003931 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 1278073003932 glutathione S-transferase; Region: PLN02395 1278073003933 GST_N family, Class Phi subfamily; composed of plant-specific class Phi GSTs and related fungal and bacterial proteins. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide...; Region: GST_N_Phi; cd03053 1278073003934 C-terminal domain interface [polypeptide binding]; other site 1278073003935 GSH binding site (G-site) [chemical binding]; other site 1278073003936 dimer interface [polypeptide binding]; other site 1278073003937 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1278073003938 N-terminal domain interface [polypeptide binding]; other site 1278073003939 dimer interface [polypeptide binding]; other site 1278073003940 substrate binding pocket (H-site) [chemical binding]; other site 1278073003941 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1278073003942 GST_N family, Class Phi subfamily; composed of plant-specific class Phi GSTs and related fungal and bacterial proteins. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide...; Region: GST_N_Phi; cd03053 1278073003943 C-terminal domain interface [polypeptide binding]; other site 1278073003944 GSH binding site (G-site) [chemical binding]; other site 1278073003945 dimer interface [polypeptide binding]; other site 1278073003946 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1278073003947 N-terminal domain interface [polypeptide binding]; other site 1278073003948 dimer interface [polypeptide binding]; other site 1278073003949 substrate binding pocket (H-site) [chemical binding]; other site 1278073003950 primosome assembly protein PriA; Validated; Region: PRK05580 1278073003951 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1278073003952 ATP binding site [chemical binding]; other site 1278073003953 putative Mg++ binding site [ion binding]; other site 1278073003954 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1278073003955 ATP-binding site [chemical binding]; other site 1278073003956 cheY-homologous receiver domain; Region: REC; smart00448 1278073003957 active site 1278073003958 phosphorylation site [posttranslational modification] 1278073003959 intermolecular recognition site; other site 1278073003960 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1278073003961 HSP70 interaction site [polypeptide binding]; other site 1278073003962 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1278073003963 active site 1278073003964 catalytic residues [active] 1278073003965 metal binding site [ion binding]; metal-binding site 1278073003966 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1278073003967 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1278073003968 minor groove reading motif; other site 1278073003969 helix-hairpin-helix signature motif; other site 1278073003970 substrate binding pocket [chemical binding]; other site 1278073003971 active site 1278073003972 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1278073003973 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1278073003974 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1278073003975 tetramer interface [polypeptide binding]; other site 1278073003976 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1278073003977 catalytic residue [active] 1278073003978 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1278073003979 Peptidase family M23; Region: Peptidase_M23; pfam01551 1278073003980 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1278073003981 IHF dimer interface [polypeptide binding]; other site 1278073003982 IHF - DNA interface [nucleotide binding]; other site 1278073003983 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1278073003984 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1278073003985 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1278073003986 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1278073003987 competence damage-inducible protein A; Provisional; Region: PRK00549 1278073003988 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1278073003989 putative MPT binding site; other site 1278073003990 Competence-damaged protein; Region: CinA; pfam02464 1278073003991 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 1278073003992 recombinase A; Provisional; Region: recA; PRK09354 1278073003993 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1278073003994 hexamer interface [polypeptide binding]; other site 1278073003995 Walker A motif; other site 1278073003996 ATP binding site [chemical binding]; other site 1278073003997 Walker B motif; other site 1278073003998 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1278073003999 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1278073004000 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1278073004001 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1278073004002 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1278073004003 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1278073004004 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073004005 Walker A motif; other site 1278073004006 ATP binding site [chemical binding]; other site 1278073004007 Walker B motif; other site 1278073004008 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1278073004009 Myxococcales-restricted protein, TIGR02265 family; Region: Mxa_TIGR02265 1278073004010 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1278073004011 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 1278073004012 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1278073004013 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1278073004014 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1278073004015 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1278073004016 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073004017 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1278073004018 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1278073004019 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 1278073004020 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1278073004021 FeS/SAM binding site; other site 1278073004022 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 1278073004023 membrane protein; Provisional; Region: PRK14400 1278073004024 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1278073004025 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1278073004026 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1278073004027 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1278073004028 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1278073004029 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1278073004030 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1278073004031 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1278073004032 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1278073004033 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 1278073004034 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1278073004035 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1278073004036 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1278073004037 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1278073004038 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1278073004039 GatB domain; Region: GatB_Yqey; smart00845 1278073004040 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1278073004041 active site 1278073004042 catalytic triad [active] 1278073004043 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1278073004044 active site 1278073004045 catalytic triad [active] 1278073004046 dimer interface [polypeptide binding]; other site 1278073004047 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 1278073004048 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1278073004049 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1278073004050 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073004051 Protein kinase domain; Region: Pkinase; pfam00069 1278073004052 active site 1278073004053 ATP binding site [chemical binding]; other site 1278073004054 substrate binding site [chemical binding]; other site 1278073004055 activation loop (A-loop); other site 1278073004056 PilZ domain; Region: PilZ; pfam07238 1278073004057 Tetratricopeptide repeat; Region: TPR_2; pfam07719 1278073004058 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1278073004059 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1278073004060 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1278073004061 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 1278073004062 GTP1/OBG; Region: GTP1_OBG; pfam01018 1278073004063 Obg GTPase; Region: Obg; cd01898 1278073004064 G1 box; other site 1278073004065 GTP/Mg2+ binding site [chemical binding]; other site 1278073004066 Switch I region; other site 1278073004067 G2 box; other site 1278073004068 G3 box; other site 1278073004069 Switch II region; other site 1278073004070 G4 box; other site 1278073004071 G5 box; other site 1278073004072 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1278073004073 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1278073004074 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 1278073004075 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1278073004076 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 1278073004077 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1278073004078 FeS/SAM binding site; other site 1278073004079 TRAM domain; Region: TRAM; pfam01938 1278073004080 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1278073004081 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1278073004082 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1278073004083 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1278073004084 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1278073004085 Putative catalytic NodB homology domain of uncharacterized prokaryotic polysaccharide deacetylases which consist of a 6-stranded beta/alpha barrel; Region: CE4_DAC_u1_6s; cd10970 1278073004086 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1278073004087 putative active site [active] 1278073004088 putative metal binding site [ion binding]; other site 1278073004089 CARDB; Region: CARDB; pfam07705 1278073004090 CARDB; Region: CARDB; pfam07705 1278073004091 CARDB; Region: CARDB; pfam07705 1278073004092 CARDB; Region: CARDB; pfam07705 1278073004093 CARDB; Region: CARDB; pfam07705 1278073004094 CARDB; Region: CARDB; pfam07705 1278073004095 CARDB; Region: CARDB; pfam07705 1278073004096 CARDB; Region: CARDB; pfam07705 1278073004097 CARDB; Region: CARDB; pfam07705 1278073004098 CARDB; Region: CARDB; pfam07705 1278073004099 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073004100 Walker A motif; other site 1278073004101 ATP binding site [chemical binding]; other site 1278073004102 Walker B motif; other site 1278073004103 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1278073004104 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073004105 Walker A motif; other site 1278073004106 ATP binding site [chemical binding]; other site 1278073004107 Walker B motif; other site 1278073004108 arginine finger; other site 1278073004109 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1278073004110 peptide chain release factor 2; Provisional; Region: PRK05589 1278073004111 PCRF domain; Region: PCRF; cl17745 1278073004112 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1278073004113 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1278073004114 active site 1278073004115 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 1278073004116 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1278073004117 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1278073004118 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1278073004119 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1278073004120 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1278073004121 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1278073004122 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1278073004123 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1278073004124 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1278073004125 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1278073004126 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1278073004127 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1278073004128 P-loop; other site 1278073004129 Magnesium ion binding site [ion binding]; other site 1278073004130 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1278073004131 Magnesium ion binding site [ion binding]; other site 1278073004132 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1278073004133 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1278073004134 phosphopeptide binding site; other site 1278073004135 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1278073004136 metal binding site [ion binding]; metal-binding site 1278073004137 I-site; other site 1278073004138 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073004139 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1278073004140 Walker A motif; other site 1278073004141 ATP binding site [chemical binding]; other site 1278073004142 Walker B motif; other site 1278073004143 arginine finger; other site 1278073004144 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1278073004145 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073004146 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073004147 active site 1278073004148 ATP binding site [chemical binding]; other site 1278073004149 substrate binding site [chemical binding]; other site 1278073004150 activation loop (A-loop); other site 1278073004151 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1278073004152 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 1278073004153 Integrase core domain; Region: rve; pfam00665 1278073004154 transposase/IS protein; Provisional; Region: PRK09183 1278073004155 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073004156 Walker A motif; other site 1278073004157 ATP binding site [chemical binding]; other site 1278073004158 Walker B motif; other site 1278073004159 Domain of unknown function (DUF4375); Region: DUF4375; pfam14300 1278073004160 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1278073004161 trimer interface [polypeptide binding]; other site 1278073004162 active site 1278073004163 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1278073004164 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1278073004165 Transposase domain (DUF772); Region: DUF772; pfam05598 1278073004166 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1278073004167 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1278073004168 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1278073004169 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073004170 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1278073004171 DNA binding residues [nucleotide binding] 1278073004172 Putative zinc-finger; Region: zf-HC2; pfam13490 1278073004173 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1278073004174 Helix-turn-helix domain; Region: HTH_18; pfam12833 1278073004175 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 1278073004176 TPR repeat; Region: TPR_11; pfam13414 1278073004177 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1278073004178 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1278073004179 phosphopeptide binding site; other site 1278073004180 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1278073004181 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073004182 Walker A motif; other site 1278073004183 ATP binding site [chemical binding]; other site 1278073004184 Walker B motif; other site 1278073004185 arginine finger; other site 1278073004186 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1278073004187 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073004188 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073004189 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073004190 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073004191 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073004192 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073004193 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073004194 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073004195 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073004196 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073004197 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073004198 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073004199 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073004200 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073004201 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073004202 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073004203 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073004204 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1278073004205 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 1278073004206 calcium binding site 2 [ion binding]; other site 1278073004207 active site 1278073004208 catalytic triad [active] 1278073004209 calcium binding site 1 [ion binding]; other site 1278073004210 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1278073004211 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1278073004212 protein-splicing catalytic site; other site 1278073004213 thioester formation/cholesterol transfer; other site 1278073004214 HEAT repeats; Region: HEAT_2; pfam13646 1278073004215 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073004216 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073004217 active site 1278073004218 ATP binding site [chemical binding]; other site 1278073004219 substrate binding site [chemical binding]; other site 1278073004220 activation loop (A-loop); other site 1278073004221 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1278073004222 Tetratricopeptide repeat; Region: TPR_10; cl17452 1278073004223 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1278073004224 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073004225 binding surface 1278073004226 TPR motif; other site 1278073004227 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1278073004228 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1278073004229 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1278073004230 HEAT repeats; Region: HEAT_2; pfam13646 1278073004231 HEAT repeats; Region: HEAT_2; pfam13646 1278073004232 HEAT repeats; Region: HEAT_2; pfam13646 1278073004233 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1278073004234 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1278073004235 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1278073004236 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 1278073004237 Helix-turn-helix domain; Region: HTH_18; pfam12833 1278073004238 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1278073004239 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1278073004240 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1278073004241 Domain of unknown function (DUF1993); Region: DUF1993; cl01567 1278073004242 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1278073004243 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 1278073004244 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 1278073004245 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1278073004246 Coenzyme A binding pocket [chemical binding]; other site 1278073004247 Dual-action HEIGH metallo-peptidase; Region: Peptidase_M57; pfam12388 1278073004248 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 1278073004249 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1278073004250 NAD(P) binding site [chemical binding]; other site 1278073004251 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1278073004252 putative trimer interface [polypeptide binding]; other site 1278073004253 putative CoA binding site [chemical binding]; other site 1278073004254 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 1278073004255 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1278073004256 active site 1278073004257 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1278073004258 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073004259 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1278073004260 NAD(P) binding site [chemical binding]; other site 1278073004261 active site 1278073004262 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 1278073004263 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1278073004264 dimer interface [polypeptide binding]; other site 1278073004265 active site 1278073004266 CoA binding pocket [chemical binding]; other site 1278073004267 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1278073004268 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1278073004269 acyl-activating enzyme (AAE) consensus motif; other site 1278073004270 AMP binding site [chemical binding]; other site 1278073004271 active site 1278073004272 CoA binding site [chemical binding]; other site 1278073004273 Dual-action HEIGH metallo-peptidase; Region: Peptidase_M57; pfam12388 1278073004274 Family description; Region: VCBS; pfam13517 1278073004275 Family description; Region: VCBS; pfam13517 1278073004276 Family description; Region: VCBS; pfam13517 1278073004277 Family description; Region: VCBS; pfam13517 1278073004278 Family description; Region: VCBS; pfam13517 1278073004279 Family description; Region: VCBS; pfam13517 1278073004280 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 1278073004281 NlpC/P60 family; Region: NLPC_P60; cl17555 1278073004282 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1278073004283 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 1278073004284 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1278073004285 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 1278073004286 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1278073004287 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 1278073004288 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1278073004289 PA14 domain; Region: PA14; cl08459 1278073004290 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 1278073004291 Predicted integral membrane protein [Function unknown]; Region: COG5658 1278073004292 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1278073004293 SdpI/YhfL protein family; Region: SdpI; pfam13630 1278073004294 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1278073004295 dimerization interface [polypeptide binding]; other site 1278073004296 putative DNA binding site [nucleotide binding]; other site 1278073004297 putative Zn2+ binding site [ion binding]; other site 1278073004298 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1278073004299 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073004300 NAD(P) binding site [chemical binding]; other site 1278073004301 active site 1278073004302 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1278073004303 active site 1278073004304 catalytic triad [active] 1278073004305 oxyanion hole [active] 1278073004306 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1278073004307 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1278073004308 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1278073004309 putative effector binding pocket; other site 1278073004310 dimerization interface [polypeptide binding]; other site 1278073004311 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073004312 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1278073004313 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1278073004314 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1278073004315 Dual-action HEIGH metallo-peptidase; Region: Peptidase_M57; pfam12388 1278073004316 hypothetical protein; Provisional; Region: PRK06834 1278073004317 hypothetical protein; Provisional; Region: PRK07236 1278073004318 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1278073004319 cytokinin dehydrogenase; Region: PLN02441 1278073004320 FAD binding domain; Region: FAD_binding_4; pfam01565 1278073004321 Cytokinin dehydrogenase 1, FAD and cytokinin binding; Region: Cytokin-bind; pfam09265 1278073004322 Protein of unknown function (DUF4241); Region: DUF4241; pfam14025 1278073004323 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1278073004324 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1278073004325 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1278073004326 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1278073004327 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1278073004328 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1278073004329 catalytic residues [active] 1278073004330 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 1278073004331 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073004332 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073004333 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073004334 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073004335 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073004336 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073004337 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1278073004338 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1278073004339 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1278073004340 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1278073004341 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1278073004342 putative C-terminal domain interface [polypeptide binding]; other site 1278073004343 putative GSH binding site (G-site) [chemical binding]; other site 1278073004344 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1278073004345 putative dimer interface [polypeptide binding]; other site 1278073004346 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 1278073004347 dimer interface [polypeptide binding]; other site 1278073004348 N-terminal domain interface [polypeptide binding]; other site 1278073004349 putative substrate binding pocket (H-site) [chemical binding]; other site 1278073004350 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 1278073004351 glutathione S-transferase; Region: PLN02395 1278073004352 putative C-terminal domain interface [polypeptide binding]; other site 1278073004353 putative GSH binding site (G-site) [chemical binding]; other site 1278073004354 putative dimer interface [polypeptide binding]; other site 1278073004355 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 1278073004356 dimer interface [polypeptide binding]; other site 1278073004357 N-terminal domain interface [polypeptide binding]; other site 1278073004358 putative substrate binding pocket (H-site) [chemical binding]; other site 1278073004359 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1278073004360 DNA-binding site [nucleotide binding]; DNA binding site 1278073004361 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1278073004362 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1278073004363 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1278073004364 hypothetical protein; Provisional; Region: PRK07236 1278073004365 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1278073004366 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1278073004367 ThiF family; Region: ThiF; pfam00899 1278073004368 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 1278073004369 ATP binding site [chemical binding]; other site 1278073004370 substrate interface [chemical binding]; other site 1278073004371 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1278073004372 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1278073004373 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 1278073004374 calcium binding site 2 [ion binding]; other site 1278073004375 active site 1278073004376 catalytic triad [active] 1278073004377 calcium binding site 1 [ion binding]; other site 1278073004378 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1278073004379 Active_site [active] 1278073004380 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 1278073004381 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1278073004382 metal ion-dependent adhesion site (MIDAS); other site 1278073004383 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 1278073004384 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 1278073004385 active site 1278073004386 metal binding site [ion binding]; metal-binding site 1278073004387 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1278073004388 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073004389 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1278073004390 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1278073004391 DNA binding residues [nucleotide binding] 1278073004392 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1278073004393 CoenzymeA binding site [chemical binding]; other site 1278073004394 subunit interaction site [polypeptide binding]; other site 1278073004395 PHB binding site; other site 1278073004396 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1278073004397 Part of AAA domain; Region: AAA_19; pfam13245 1278073004398 Family description; Region: UvrD_C_2; pfam13538 1278073004399 PQQ-like domain; Region: PQQ_2; pfam13360 1278073004400 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1278073004401 active site 1278073004402 Trp docking motif [polypeptide binding]; other site 1278073004403 PQQ-like domain; Region: PQQ_2; pfam13360 1278073004404 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1278073004405 active site 1278073004406 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1278073004407 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1278073004408 active site 1278073004409 purine riboside binding site [chemical binding]; other site 1278073004410 short chain dehydrogenase; Provisional; Region: PRK07062 1278073004411 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1278073004412 putative NAD(P) binding site [chemical binding]; other site 1278073004413 putative active site [active] 1278073004414 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1278073004415 hypothetical protein; Reviewed; Region: PRK09588 1278073004416 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1278073004417 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1278073004418 Coenzyme A binding pocket [chemical binding]; other site 1278073004419 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1278073004420 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1278073004421 ligand binding site; other site 1278073004422 oligomer interface; other site 1278073004423 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1278073004424 dimer interface [polypeptide binding]; other site 1278073004425 N-terminal domain interface [polypeptide binding]; other site 1278073004426 sulfate 1 binding site; other site 1278073004427 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1278073004428 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1278073004429 phosphopeptide binding site; other site 1278073004430 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1278073004431 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1278073004432 metal binding site [ion binding]; metal-binding site 1278073004433 active site 1278073004434 I-site; other site 1278073004435 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1278073004436 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073004437 NAD(P) binding site [chemical binding]; other site 1278073004438 active site 1278073004439 fatty acyl-CoA reductase; Region: PLN02996 1278073004440 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073004441 NAD(P) binding site [chemical binding]; other site 1278073004442 active site 1278073004443 C-terminal domain of fatty acyl CoA reductases; Region: FAR_C; cd09071 1278073004444 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1278073004445 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1278073004446 acyl-activating enzyme (AAE) consensus motif; other site 1278073004447 putative AMP binding site [chemical binding]; other site 1278073004448 putative active site [active] 1278073004449 putative CoA binding site [chemical binding]; other site 1278073004450 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1278073004451 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1278073004452 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1278073004453 putative acyl-acceptor binding pocket; other site 1278073004454 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 1278073004455 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1278073004456 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1278073004457 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1278073004458 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073004459 NAD(P) binding site [chemical binding]; other site 1278073004460 active site 1278073004461 SWI complex, BAF60b domains; Region: SWIB; smart00151 1278073004462 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 1278073004463 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1278073004464 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 1278073004465 active site 1278073004466 catalytic site [active] 1278073004467 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1278073004468 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1278073004469 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1278073004470 active site 1278073004471 catalytic site [active] 1278073004472 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1278073004473 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 1278073004474 ferrochelatase; Reviewed; Region: hemH; PRK00035 1278073004475 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1278073004476 C-terminal domain interface [polypeptide binding]; other site 1278073004477 active site 1278073004478 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1278073004479 active site 1278073004480 N-terminal domain interface [polypeptide binding]; other site 1278073004481 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1278073004482 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1278073004483 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 1278073004484 putative hydrophobic ligand binding site [chemical binding]; other site 1278073004485 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073004486 TIGR01777 family protein; Region: yfcH 1278073004487 NAD(P) binding site [chemical binding]; other site 1278073004488 active site 1278073004489 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1278073004490 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1278073004491 Walker A/P-loop; other site 1278073004492 ATP binding site [chemical binding]; other site 1278073004493 Q-loop/lid; other site 1278073004494 ABC transporter signature motif; other site 1278073004495 Walker B; other site 1278073004496 D-loop; other site 1278073004497 H-loop/switch region; other site 1278073004498 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 1278073004499 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1278073004500 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 1278073004501 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 1278073004502 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 1278073004503 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 1278073004504 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073004505 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073004506 active site 1278073004507 phosphorylation site [posttranslational modification] 1278073004508 intermolecular recognition site; other site 1278073004509 dimerization interface [polypeptide binding]; other site 1278073004510 PAS domain; Region: PAS; smart00091 1278073004511 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1278073004512 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1278073004513 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073004514 dimer interface [polypeptide binding]; other site 1278073004515 phosphorylation site [posttranslational modification] 1278073004516 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073004517 ATP binding site [chemical binding]; other site 1278073004518 Mg2+ binding site [ion binding]; other site 1278073004519 G-X-G motif; other site 1278073004520 Gas vesicle protein; Region: Gas_vesicle; cl02954 1278073004521 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1278073004522 endonuclease III; Region: ENDO3c; smart00478 1278073004523 minor groove reading motif; other site 1278073004524 helix-hairpin-helix signature motif; other site 1278073004525 substrate binding pocket [chemical binding]; other site 1278073004526 active site 1278073004527 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1278073004528 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1278073004529 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003 1278073004530 muropeptide transporter; Reviewed; Region: ampG; PRK11902 1278073004531 muropeptide transporter; Validated; Region: ampG; cl17669 1278073004532 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1278073004533 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1278073004534 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1278073004535 homodimer interface [polypeptide binding]; other site 1278073004536 catalytic residue [active] 1278073004537 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1278073004538 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1278073004539 dimerization interface [polypeptide binding]; other site 1278073004540 DPS ferroxidase diiron center [ion binding]; other site 1278073004541 ion pore; other site 1278073004542 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 1278073004543 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; cl09775 1278073004544 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1278073004545 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1278073004546 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1278073004547 dimer interface [polypeptide binding]; other site 1278073004548 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1278073004549 catalytic triad [active] 1278073004550 peroxidatic and resolving cysteines [active] 1278073004551 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 1278073004552 GAF domain; Region: GAF_3; pfam13492 1278073004553 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073004554 Walker A motif; other site 1278073004555 ATP binding site [chemical binding]; other site 1278073004556 Walker B motif; other site 1278073004557 arginine finger; other site 1278073004558 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1278073004559 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1278073004560 substrate binding pocket [chemical binding]; other site 1278073004561 membrane-bound complex binding site; other site 1278073004562 hinge residues; other site 1278073004563 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1278073004564 dimer interface [polypeptide binding]; other site 1278073004565 conserved gate region; other site 1278073004566 putative PBP binding loops; other site 1278073004567 ABC-ATPase subunit interface; other site 1278073004568 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1278073004569 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1278073004570 Walker A/P-loop; other site 1278073004571 ATP binding site [chemical binding]; other site 1278073004572 Q-loop/lid; other site 1278073004573 ABC transporter signature motif; other site 1278073004574 Walker B; other site 1278073004575 D-loop; other site 1278073004576 H-loop/switch region; other site 1278073004577 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1278073004578 GAF domain; Region: GAF; pfam01590 1278073004579 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073004580 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073004581 dimer interface [polypeptide binding]; other site 1278073004582 phosphorylation site [posttranslational modification] 1278073004583 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073004584 ATP binding site [chemical binding]; other site 1278073004585 Mg2+ binding site [ion binding]; other site 1278073004586 G-X-G motif; other site 1278073004587 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1278073004588 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1278073004589 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 1278073004590 uncharacterized proteins similar to the Aspergillus nidulans lactam utilization protein LamB; Region: LamB_YcsF_like_1; cd10801 1278073004591 putative active site [active] 1278073004592 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1278073004593 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1278073004594 Cytochrome c; Region: Cytochrom_C; pfam00034 1278073004595 Cytochrome c; Region: Cytochrom_C; cl11414 1278073004596 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1278073004597 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1278073004598 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1278073004599 catalytic residue [active] 1278073004600 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1278073004601 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1278073004602 dimer interface [polypeptide binding]; other site 1278073004603 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1278073004604 catalytic residue [active] 1278073004605 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1278073004606 serine O-acetyltransferase; Region: cysE; TIGR01172 1278073004607 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1278073004608 trimer interface [polypeptide binding]; other site 1278073004609 active site 1278073004610 substrate binding site [chemical binding]; other site 1278073004611 CoA binding site [chemical binding]; other site 1278073004612 AMP-binding domain protein; Validated; Region: PRK08315 1278073004613 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 1278073004614 acyl-activating enzyme (AAE) consensus motif; other site 1278073004615 putative AMP binding site [chemical binding]; other site 1278073004616 putative active site [active] 1278073004617 putative CoA binding site [chemical binding]; other site 1278073004618 TfoX N-terminal domain; Region: TfoX_N; pfam04993 1278073004619 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1278073004620 putative catalytic site [active] 1278073004621 putative metal binding site [ion binding]; other site 1278073004622 putative phosphate binding site [ion binding]; other site 1278073004623 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1278073004624 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1278073004625 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1278073004626 dimerization interface [polypeptide binding]; other site 1278073004627 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1278073004628 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1278073004629 putative substrate translocation pore; other site 1278073004630 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1278073004631 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073004632 active site 1278073004633 ATP binding site [chemical binding]; other site 1278073004634 substrate binding site [chemical binding]; other site 1278073004635 activation loop (A-loop); other site 1278073004636 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1278073004637 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1278073004638 Predicted membrane protein [Function unknown]; Region: COG1238 1278073004639 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1278073004640 putative catalytic site [active] 1278073004641 putative phosphate binding site [ion binding]; other site 1278073004642 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 1278073004643 Lamin Tail Domain; Region: LTD; pfam00932 1278073004644 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1278073004645 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1278073004646 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1278073004647 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1278073004648 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 1278073004649 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1278073004650 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1278073004651 active site 1278073004652 Serine hydrolase; Region: Ser_hydrolase; cl17834 1278073004653 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1278073004654 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1278073004655 Aminotransferase class IV; Region: Aminotran_4; pfam01063 1278073004656 substrate-cofactor binding pocket; other site 1278073004657 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1278073004658 homodimer interface [polypeptide binding]; other site 1278073004659 catalytic residue [active] 1278073004660 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1278073004661 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1278073004662 glutamine binding [chemical binding]; other site 1278073004663 catalytic triad [active] 1278073004664 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1278073004665 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1278073004666 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1278073004667 AAA ATPase domain; Region: AAA_16; pfam13191 1278073004668 Walker A motif; other site 1278073004669 ATP binding site [chemical binding]; other site 1278073004670 AAA-like domain; Region: AAA_10; pfam12846 1278073004671 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 1278073004672 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1278073004673 putative active site [active] 1278073004674 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073004675 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1278073004676 NAD(P) binding site [chemical binding]; other site 1278073004677 active site 1278073004678 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1278073004679 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1278073004680 putative acyl-acceptor binding pocket; other site 1278073004681 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1278073004682 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 1278073004683 Walker A/P-loop; other site 1278073004684 ATP binding site [chemical binding]; other site 1278073004685 Q-loop/lid; other site 1278073004686 ABC transporter signature motif; other site 1278073004687 Walker B; other site 1278073004688 D-loop; other site 1278073004689 H-loop/switch region; other site 1278073004690 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1278073004691 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1278073004692 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1278073004693 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 1278073004694 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073004695 S-adenosylmethionine binding site [chemical binding]; other site 1278073004696 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1278073004697 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 1278073004698 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073004699 S-adenosylmethionine binding site [chemical binding]; other site 1278073004700 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1278073004701 FtsX-like permease family; Region: FtsX; pfam02687 1278073004702 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1278073004703 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1278073004704 acyl-activating enzyme (AAE) consensus motif; other site 1278073004705 AMP binding site [chemical binding]; other site 1278073004706 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073004707 Condensation domain; Region: Condensation; pfam00668 1278073004708 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073004709 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073004710 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073004711 acyl-activating enzyme (AAE) consensus motif; other site 1278073004712 AMP binding site [chemical binding]; other site 1278073004713 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073004714 Condensation domain; Region: Condensation; pfam00668 1278073004715 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073004716 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073004717 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073004718 acyl-activating enzyme (AAE) consensus motif; other site 1278073004719 AMP binding site [chemical binding]; other site 1278073004720 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073004721 Condensation domain; Region: Condensation; pfam00668 1278073004722 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073004723 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073004724 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073004725 acyl-activating enzyme (AAE) consensus motif; other site 1278073004726 AMP binding site [chemical binding]; other site 1278073004727 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073004728 Condensation domain; Region: Condensation; pfam00668 1278073004729 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073004730 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073004731 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073004732 acyl-activating enzyme (AAE) consensus motif; other site 1278073004733 AMP binding site [chemical binding]; other site 1278073004734 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1278073004735 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1278073004736 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1278073004737 iron-sulfur cluster [ion binding]; other site 1278073004738 [2Fe-2S] cluster binding site [ion binding]; other site 1278073004739 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1278073004740 hydrophobic ligand binding site; other site 1278073004741 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1278073004742 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 1278073004743 heme-binding residues [chemical binding]; other site 1278073004744 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1278073004745 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1278073004746 Pirin-related protein [General function prediction only]; Region: COG1741 1278073004747 Pirin; Region: Pirin; pfam02678 1278073004748 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1278073004749 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1278073004750 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1278073004751 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1278073004752 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1278073004753 DNA-binding site [nucleotide binding]; DNA binding site 1278073004754 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1278073004755 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1278073004756 homodimer interface [polypeptide binding]; other site 1278073004757 catalytic residue [active] 1278073004758 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1278073004759 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1278073004760 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1278073004761 DNA-binding site [nucleotide binding]; DNA binding site 1278073004762 RNA-binding motif; other site 1278073004763 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1278073004764 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073004765 Walker A/P-loop; other site 1278073004766 ATP binding site [chemical binding]; other site 1278073004767 Q-loop/lid; other site 1278073004768 ABC transporter signature motif; other site 1278073004769 Walker B; other site 1278073004770 D-loop; other site 1278073004771 H-loop/switch region; other site 1278073004772 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1278073004773 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1278073004774 Zn binding site [ion binding]; other site 1278073004775 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 1278073004776 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1278073004777 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1278073004778 acyl-activating enzyme (AAE) consensus motif; other site 1278073004779 putative AMP binding site [chemical binding]; other site 1278073004780 putative active site [active] 1278073004781 putative CoA binding site [chemical binding]; other site 1278073004782 HTH domain; Region: HTH_11; pfam08279 1278073004783 WYL domain; Region: WYL; pfam13280 1278073004784 DNA polymerase elongation subunit (family B) [DNA replication, recombination, and repair]; Region: PolB; COG0417 1278073004785 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1278073004786 active site 1278073004787 catalytic site [active] 1278073004788 substrate binding site [chemical binding]; other site 1278073004789 DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both...; Region: POLBc; cl10023 1278073004790 active site 1278073004791 metal-binding site 1278073004792 Histidine kinase; Region: His_kinase; pfam06580 1278073004793 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073004794 ATP binding site [chemical binding]; other site 1278073004795 Mg2+ binding site [ion binding]; other site 1278073004796 G-X-G motif; other site 1278073004797 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1278073004798 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073004799 active site 1278073004800 phosphorylation site [posttranslational modification] 1278073004801 intermolecular recognition site; other site 1278073004802 dimerization interface [polypeptide binding]; other site 1278073004803 LytTr DNA-binding domain; Region: LytTR; smart00850 1278073004804 The C-terminal domain of uncharacterized bacterial proteins; Region: Bvu_2165_C_like; cd12843 1278073004805 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1278073004806 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1278073004807 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 1278073004808 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 1278073004809 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1278073004810 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1278073004811 FtsX-like permease family; Region: FtsX; pfam02687 1278073004812 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1278073004813 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1278073004814 short chain dehydrogenase; Provisional; Region: PRK06500 1278073004815 classical (c) SDRs; Region: SDR_c; cd05233 1278073004816 NAD(P) binding site [chemical binding]; other site 1278073004817 active site 1278073004818 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1278073004819 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1278073004820 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1278073004821 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1278073004822 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1278073004823 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1278073004824 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1278073004825 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1278073004826 active site 1278073004827 Zn binding site [ion binding]; other site 1278073004828 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1278073004829 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 1278073004830 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1278073004831 catalytic residue [active] 1278073004832 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1278073004833 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 1278073004834 putative hydrophobic ligand binding site [chemical binding]; other site 1278073004835 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1278073004836 Peptidase family M23; Region: Peptidase_M23; pfam01551 1278073004837 Cellulose binding domain; Region: CBM_2; cl17741 1278073004838 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1278073004839 Interdomain contacts; other site 1278073004840 Cytokine receptor motif; other site 1278073004841 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1278073004842 active site 1278073004843 Penicillinase repressor; Region: Pencillinase_R; cl17580 1278073004844 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 1278073004845 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 1278073004846 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073004847 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073004848 Erythromycin esterase; Region: Erythro_esteras; pfam05139 1278073004849 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073004850 Erythromycin esterase; Region: Erythro_esteras; pfam05139 1278073004851 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1278073004852 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1278073004853 putative active site [active] 1278073004854 heme pocket [chemical binding]; other site 1278073004855 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073004856 ATP binding site [chemical binding]; other site 1278073004857 Mg2+ binding site [ion binding]; other site 1278073004858 G-X-G motif; other site 1278073004859 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1278073004860 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1278073004861 active site 1278073004862 Spore Coat Protein U domain; Region: SCPU; pfam05229 1278073004863 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1278073004864 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1278073004865 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1278073004866 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1278073004867 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1278073004868 Spore Coat Protein U domain; Region: SCPU; pfam05229 1278073004869 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 1278073004870 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1278073004871 Glyco_18 domain; Region: Glyco_18; smart00636 1278073004872 active site 1278073004873 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1278073004874 homotrimer interaction site [polypeptide binding]; other site 1278073004875 putative active site [active] 1278073004876 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1278073004877 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 1278073004878 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1278073004879 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 1278073004880 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1278073004881 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1278073004882 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1278073004883 Kelch domain; Region: Kelch; smart00612 1278073004884 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1278073004885 Kelch domain; Region: Kelch; smart00612 1278073004886 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1278073004887 HYR domain; Region: HYR; pfam02494 1278073004888 HYR domain; Region: HYR; pfam02494 1278073004889 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1278073004890 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1278073004891 ligand binding site [chemical binding]; other site 1278073004892 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1278073004893 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1278073004894 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1278073004895 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1278073004896 dimerization interface [polypeptide binding]; other site 1278073004897 substrate binding pocket [chemical binding]; other site 1278073004898 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 1278073004899 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 1278073004900 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 1278073004901 SnoaL-like domain; Region: SnoaL_3; pfam13474 1278073004902 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1278073004903 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1278073004904 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1278073004905 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1278073004906 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1278073004907 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073004908 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1278073004909 DNA binding residues [nucleotide binding] 1278073004910 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1278073004911 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 1278073004912 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1278073004913 putative di-iron ligands [ion binding]; other site 1278073004914 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1278073004915 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1278073004916 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073004917 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1278073004918 Walker A/P-loop; other site 1278073004919 ATP binding site [chemical binding]; other site 1278073004920 Q-loop/lid; other site 1278073004921 ABC transporter signature motif; other site 1278073004922 Walker B; other site 1278073004923 D-loop; other site 1278073004924 H-loop/switch region; other site 1278073004925 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1278073004926 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1278073004927 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073004928 Walker A/P-loop; other site 1278073004929 ATP binding site [chemical binding]; other site 1278073004930 Q-loop/lid; other site 1278073004931 ABC transporter signature motif; other site 1278073004932 Walker B; other site 1278073004933 D-loop; other site 1278073004934 H-loop/switch region; other site 1278073004935 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 1278073004936 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1278073004937 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1278073004938 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073004939 active site 1278073004940 phosphorylation site [posttranslational modification] 1278073004941 intermolecular recognition site; other site 1278073004942 dimerization interface [polypeptide binding]; other site 1278073004943 LytTr DNA-binding domain; Region: LytTR; smart00850 1278073004944 Histidine kinase; Region: His_kinase; pfam06580 1278073004945 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073004946 ATP binding site [chemical binding]; other site 1278073004947 Mg2+ binding site [ion binding]; other site 1278073004948 G-X-G motif; other site 1278073004949 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1278073004950 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1278073004951 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1278073004952 homodimer interface [polypeptide binding]; other site 1278073004953 catalytic residue [active] 1278073004954 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1278073004955 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1278073004956 MepB protein; Region: MepB; cl01985 1278073004957 TAP-like protein; Region: Abhydrolase_4; pfam08386 1278073004958 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1278073004959 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1278073004960 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1278073004961 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1278073004962 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1278073004963 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1278073004964 DNA-binding site [nucleotide binding]; DNA binding site 1278073004965 RNA-binding motif; other site 1278073004966 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1278073004967 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1278073004968 PhnA protein; Region: PhnA; pfam03831 1278073004969 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 1278073004970 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073004971 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073004972 active site 1278073004973 substrate binding site [chemical binding]; other site 1278073004974 ATP binding site [chemical binding]; other site 1278073004975 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1278073004976 substrate binding site [chemical binding]; other site 1278073004977 activation loop (A-loop); other site 1278073004978 activation loop (A-loop); other site 1278073004979 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1278073004980 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1278073004981 non-specific DNA binding site [nucleotide binding]; other site 1278073004982 sequence-specific DNA binding site [nucleotide binding]; other site 1278073004983 salt bridge; other site 1278073004984 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1278073004985 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1278073004986 non-specific DNA binding site [nucleotide binding]; other site 1278073004987 salt bridge; other site 1278073004988 sequence-specific DNA binding site [nucleotide binding]; other site 1278073004989 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073004990 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073004991 active site 1278073004992 ATP binding site [chemical binding]; other site 1278073004993 substrate binding site [chemical binding]; other site 1278073004994 activation loop (A-loop); other site 1278073004995 Protein of unknown function (DUF2381); Region: DUF2381; pfam09544 1278073004996 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1278073004997 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 1278073004998 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1278073004999 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 1278073005000 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1278073005001 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 1278073005002 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1278073005003 violacein biosynthesis enzyme VioE; Region: violacein_E; TIGR03650 1278073005004 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1278073005005 hypothetical protein; Provisional; Region: PRK07236 1278073005006 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1278073005007 Ferritin-like; Region: Ferritin-like; pfam12902 1278073005008 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1278073005009 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1278073005010 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1278073005011 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1278073005012 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1278073005013 putative effector binding pocket; other site 1278073005014 putative dimerization interface [polypeptide binding]; other site 1278073005015 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1278073005016 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1278073005017 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1278073005018 Sulfatase; Region: Sulfatase; pfam00884 1278073005019 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1278073005020 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073005021 Walker A motif; other site 1278073005022 ATP binding site [chemical binding]; other site 1278073005023 Walker B motif; other site 1278073005024 arginine finger; other site 1278073005025 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1278073005026 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1278073005027 catalytic residue [active] 1278073005028 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1278073005029 B12-binding domain/radical SAM domain protein, Ta0216 family; Region: B12_SAM_Ta0216; TIGR04190 1278073005030 B12 binding site [chemical binding]; other site 1278073005031 G8 domain; Region: G8; pfam10162 1278073005032 Right handed beta helix region; Region: Beta_helix; pfam13229 1278073005033 Right handed beta helix region; Region: Beta_helix; pfam13229 1278073005034 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1278073005035 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 1278073005036 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1278073005037 catalytic residue [active] 1278073005038 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 1278073005039 Pleckstrin homology-like domain; Region: PH-like; cl17171 1278073005040 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 1278073005041 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1278073005042 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1278073005043 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 1278073005044 HlyD family secretion protein; Region: HlyD_3; pfam13437 1278073005045 Outer membrane efflux protein; Region: OEP; pfam02321 1278073005046 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1278073005047 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1278073005048 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1278073005049 NlpC/P60 family; Region: NLPC_P60; cl17555 1278073005050 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 1278073005051 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073005052 Walker A motif; other site 1278073005053 ATP binding site [chemical binding]; other site 1278073005054 Walker B motif; other site 1278073005055 arginine finger; other site 1278073005056 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 1278073005057 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1278073005058 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1278073005059 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1278073005060 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1278073005061 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1278073005062 phosphopeptide binding site; other site 1278073005063 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1278073005064 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073005065 Walker A motif; other site 1278073005066 ATP binding site [chemical binding]; other site 1278073005067 Walker B motif; other site 1278073005068 arginine finger; other site 1278073005069 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073005070 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073005071 active site 1278073005072 ATP binding site [chemical binding]; other site 1278073005073 substrate binding site [chemical binding]; other site 1278073005074 activation loop (A-loop); other site 1278073005075 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1278073005076 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1278073005077 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1278073005078 dimerization interface [polypeptide binding]; other site 1278073005079 Predicted membrane protein [Function unknown]; Region: COG2855 1278073005080 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1278073005081 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1278073005082 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1278073005083 putative dimerization interface [polypeptide binding]; other site 1278073005084 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1278073005085 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1278073005086 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1278073005087 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1278073005088 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1278073005089 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1278073005090 Di-iron ligands [ion binding]; other site 1278073005091 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1278073005092 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 1278073005093 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1278073005094 nucleophilic elbow; other site 1278073005095 catalytic triad; other site 1278073005096 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1278073005097 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1278073005098 putative di-iron ligands [ion binding]; other site 1278073005099 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1278073005100 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1278073005101 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1278073005102 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1278073005103 putative NADP binding site [chemical binding]; other site 1278073005104 active site 1278073005105 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1278073005106 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073005107 S-adenosylmethionine binding site [chemical binding]; other site 1278073005108 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1278073005109 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1278073005110 substrate binding site [chemical binding]; other site 1278073005111 oxyanion hole (OAH) forming residues; other site 1278073005112 trimer interface [polypeptide binding]; other site 1278073005113 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073005114 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073005115 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1278073005116 active site 1278073005117 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1278073005118 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1278073005119 putative NADP binding site [chemical binding]; other site 1278073005120 active site 1278073005121 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073005122 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073005123 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1278073005124 active site 1278073005125 acyl-CoA synthetase; Validated; Region: PRK05850 1278073005126 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1278073005127 acyl-activating enzyme (AAE) consensus motif; other site 1278073005128 active site 1278073005129 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1278073005130 EamA-like transporter family; Region: EamA; pfam00892 1278073005131 EamA-like transporter family; Region: EamA; pfam00892 1278073005132 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1278073005133 Helix-turn-helix domain; Region: HTH_18; pfam12833 1278073005134 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1278073005135 SnoaL-like domain; Region: SnoaL_2; pfam12680 1278073005136 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1278073005137 short chain dehydrogenase; Provisional; Region: PRK12744 1278073005138 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073005139 NAD(P) binding site [chemical binding]; other site 1278073005140 active site 1278073005141 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1278073005142 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1278073005143 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1278073005144 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1278073005145 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1278073005146 conserved cys residue [active] 1278073005147 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1278073005148 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 1278073005149 Arginine methyltransferase-interacting protein, contains RING Zn-finger [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: AIR1; COG5082 1278073005150 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1278073005151 catalytic residues [active] 1278073005152 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 1278073005153 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 1278073005154 Phage protein GP46; Region: GP46; pfam07409 1278073005155 Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; cl15410 1278073005156 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1278073005157 DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157 1278073005158 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 1278073005159 Phage tail tube protein; Region: Tail_tube; pfam10618 1278073005160 Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386 1278073005161 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 1278073005162 Protein of unknown function (DUF2635); Region: DUF2635; pfam10948 1278073005163 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; cl05094 1278073005164 Uncharacterized conserved protein (DUF2190); Region: DUF2190; pfam09956 1278073005165 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 1278073005166 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 1278073005167 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 1278073005168 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 1278073005169 Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720 1278073005170 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1278073005171 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1278073005172 active site 1278073005173 HIGH motif; other site 1278073005174 dimer interface [polypeptide binding]; other site 1278073005175 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1278073005176 KMSKS motif; other site 1278073005177 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 1278073005178 polymerase nucleotide-binding site; other site 1278073005179 DNA-binding residues [nucleotide binding]; DNA binding site 1278073005180 nucleotide binding site [chemical binding]; other site 1278073005181 primase nucleotide-binding site [nucleotide binding]; other site 1278073005182 VRR-NUC domain; Region: VRR_NUC; pfam08774 1278073005183 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1278073005184 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1278073005185 ATP binding site [chemical binding]; other site 1278073005186 putative Mg++ binding site [ion binding]; other site 1278073005187 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1278073005188 nucleotide binding region [chemical binding]; other site 1278073005189 ATP-binding site [chemical binding]; other site 1278073005190 Domain of Unknown Function with PDB structure (DUF3850); Region: DUF3850; pfam12961 1278073005191 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1278073005192 putative DNA binding site [nucleotide binding]; other site 1278073005193 putative Zn2+ binding site [ion binding]; other site 1278073005194 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1278073005195 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1278073005196 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 1278073005197 DNA binding site [nucleotide binding] 1278073005198 active site 1278073005199 catalytic site [active] 1278073005200 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 1278073005201 HD domain; Region: HD_3; cl17350 1278073005202 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1278073005203 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1278073005204 active site 1278073005205 catalytic site [active] 1278073005206 substrate binding site [chemical binding]; other site 1278073005207 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; cl05442 1278073005208 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1278073005209 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1278073005210 cofactor binding site; other site 1278073005211 DNA binding site [nucleotide binding] 1278073005212 substrate interaction site [chemical binding]; other site 1278073005213 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1278073005214 Helix-turn-helix domain; Region: HTH_17; cl17695 1278073005215 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1278073005216 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1278073005217 active site 1278073005218 catalytic residues [active] 1278073005219 DNA binding site [nucleotide binding] 1278073005220 Int/Topo IB signature motif; other site 1278073005221 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1278073005222 PemK-like protein; Region: PemK; pfam02452 1278073005223 Uncharacterized conserved protein [Function unknown]; Region: COG5276 1278073005224 Uncharacterized conserved protein [Function unknown]; Region: COG5276 1278073005225 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1278073005226 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1278073005227 catalytic loop [active] 1278073005228 iron binding site [ion binding]; other site 1278073005229 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1278073005230 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1278073005231 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1278073005232 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1278073005233 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1278073005234 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1278073005235 multidrug efflux protein; Reviewed; Region: PRK09579 1278073005236 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1278073005237 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1278073005238 HlyD family secretion protein; Region: HlyD_3; pfam13437 1278073005239 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1278073005240 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1278073005241 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1278073005242 active site 1278073005243 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 1278073005244 Cytochrome c; Region: Cytochrom_C; pfam00034 1278073005245 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1278073005246 putative acyltransferase; Provisional; Region: PRK05790 1278073005247 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1278073005248 dimer interface [polypeptide binding]; other site 1278073005249 active site 1278073005250 Coenzyme A transferase; Region: CoA_trans; cl17247 1278073005251 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1278073005252 4-aminobutyrate aminotransferase; Provisional; Region: PRK05769 1278073005253 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1278073005254 inhibitor-cofactor binding pocket; inhibition site 1278073005255 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1278073005256 catalytic residue [active] 1278073005257 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1278073005258 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1278073005259 NAD(P) binding site [chemical binding]; other site 1278073005260 catalytic residues [active] 1278073005261 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 1278073005262 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1278073005263 inhibitor-cofactor binding pocket; inhibition site 1278073005264 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1278073005265 catalytic residue [active] 1278073005266 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 1278073005267 active site 1 [active] 1278073005268 dimer interface [polypeptide binding]; other site 1278073005269 hexamer interface [polypeptide binding]; other site 1278073005270 active site 2 [active] 1278073005271 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 1278073005272 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1278073005273 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1278073005274 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1278073005275 putative effector binding pocket; other site 1278073005276 dimerization interface [polypeptide binding]; other site 1278073005277 Pectic acid lyase; Region: Pec_lyase; pfam09492 1278073005278 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1278073005279 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073005280 S-adenosylmethionine binding site [chemical binding]; other site 1278073005281 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1278073005282 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1278073005283 DNA binding residues [nucleotide binding] 1278073005284 drug binding residues [chemical binding]; other site 1278073005285 dimer interface [polypeptide binding]; other site 1278073005286 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1278073005287 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1278073005288 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; cl17321 1278073005289 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1278073005290 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1278073005291 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1278073005292 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1278073005293 dimerization interface [polypeptide binding]; other site 1278073005294 substrate binding pocket [chemical binding]; other site 1278073005295 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1278073005296 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1278073005297 TPR motif; other site 1278073005298 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 1278073005299 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 1278073005300 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1278073005301 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1278073005302 DNA binding residues [nucleotide binding] 1278073005303 dimerization interface [polypeptide binding]; other site 1278073005304 RibD C-terminal domain; Region: RibD_C; cl17279 1278073005305 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1278073005306 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1278073005307 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073005308 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1278073005309 DNA binding residues [nucleotide binding] 1278073005310 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1278073005311 dimer interface [polypeptide binding]; other site 1278073005312 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1278073005313 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1278073005314 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1278073005315 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1278073005316 active site 1278073005317 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1278073005318 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1278073005319 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1278073005320 putative effector binding pocket; other site 1278073005321 dimerization interface [polypeptide binding]; other site 1278073005322 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1278073005323 homotrimer interaction site [polypeptide binding]; other site 1278073005324 putative active site [active] 1278073005325 putative dehydratase; Provisional; Region: PRK08211 1278073005326 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1278073005327 putative catalytic site [active] 1278073005328 putative metal binding site [ion binding]; other site 1278073005329 putative phosphate binding site [ion binding]; other site 1278073005330 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1278073005331 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1278073005332 active site 1278073005333 catalytic tetrad [active] 1278073005334 YCII-related domain; Region: YCII; cl00999 1278073005335 YCII-related domain; Region: YCII; cl00999 1278073005336 Protein of unknown function (DUF808); Region: DUF808; pfam05661 1278073005337 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1278073005338 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1278073005339 DNA-binding site [nucleotide binding]; DNA binding site 1278073005340 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1278073005341 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1278073005342 Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417 1278073005343 AAA domain; Region: AAA_28; pfam13521 1278073005344 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073005345 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073005346 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073005347 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073005348 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073005349 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073005350 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073005351 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073005352 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073005353 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073005354 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073005355 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073005356 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073005357 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073005358 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1278073005359 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073005360 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1278073005361 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1278073005362 N-terminal plug; other site 1278073005363 ligand-binding site [chemical binding]; other site 1278073005364 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1278073005365 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1278073005366 FeS/SAM binding site; other site 1278073005367 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1278073005368 nudix motif; other site 1278073005369 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1278073005370 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1278073005371 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1278073005372 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1278073005373 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1278073005374 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1278073005375 HlyD family secretion protein; Region: HlyD_3; pfam13437 1278073005376 Cytochrome c; Region: Cytochrom_C; cl11414 1278073005377 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1278073005378 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1278073005379 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1278073005380 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1278073005381 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1278073005382 catalytic residue [active] 1278073005383 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1278073005384 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1278073005385 C factor cell-cell signaling protein; Provisional; Region: PRK09009 1278073005386 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 1278073005387 NADP binding site [chemical binding]; other site 1278073005388 homodimer interface [polypeptide binding]; other site 1278073005389 active site 1278073005390 Poly (ADP-ribose) glycohydrolase (PARG); Region: PARG_cat; pfam05028 1278073005391 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 1278073005392 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1278073005393 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1278073005394 H+ Antiporter protein; Region: 2A0121; TIGR00900 1278073005395 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1278073005396 putative substrate translocation pore; other site 1278073005397 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768 1278073005398 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1278073005399 acyl-activating enzyme (AAE) consensus motif; other site 1278073005400 AMP binding site [chemical binding]; other site 1278073005401 active site 1278073005402 CoA binding site [chemical binding]; other site 1278073005403 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073005404 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1278073005405 Condensation domain; Region: Condensation; pfam00668 1278073005406 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073005407 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 1278073005408 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1278073005409 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1278073005410 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073005411 acyl-activating enzyme (AAE) consensus motif; other site 1278073005412 AMP binding site [chemical binding]; other site 1278073005413 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073005414 Thioesterase; Region: PKS_TE; smart00824 1278073005415 Condensation domain; Region: Condensation; pfam00668 1278073005416 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073005417 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073005418 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1278073005419 acyl-activating enzyme (AAE) consensus motif; other site 1278073005420 AMP binding site [chemical binding]; other site 1278073005421 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073005422 Condensation domain; Region: Condensation; pfam00668 1278073005423 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073005424 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1278073005425 acyl-activating enzyme (AAE) consensus motif; other site 1278073005426 AMP binding site [chemical binding]; other site 1278073005427 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073005428 Condensation domain; Region: Condensation; pfam00668 1278073005429 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073005430 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073005431 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073005432 acyl-activating enzyme (AAE) consensus motif; other site 1278073005433 AMP binding site [chemical binding]; other site 1278073005434 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073005435 Condensation domain; Region: Condensation; pfam00668 1278073005436 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073005437 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073005438 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 1278073005439 acyl-activating enzyme (AAE) consensus motif; other site 1278073005440 AMP binding site [chemical binding]; other site 1278073005441 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073005442 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1278073005443 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073005444 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 1278073005445 acyl-activating enzyme (AAE) consensus motif; other site 1278073005446 AMP binding site [chemical binding]; other site 1278073005447 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073005448 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1278073005449 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073005450 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1278073005451 active site 1278073005452 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1278073005453 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1278073005454 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1278073005455 putative NADP binding site [chemical binding]; other site 1278073005456 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1278073005457 active site 1278073005458 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1278073005459 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073005460 Condensation domain; Region: Condensation; pfam00668 1278073005461 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1278073005462 Condensation domain; Region: Condensation; pfam00668 1278073005463 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073005464 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1278073005465 acyl-activating enzyme (AAE) consensus motif; other site 1278073005466 AMP binding site [chemical binding]; other site 1278073005467 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073005468 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1278073005469 acyl-CoA synthetase; Validated; Region: PRK05850 1278073005470 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1278073005471 acyl-activating enzyme (AAE) consensus motif; other site 1278073005472 active site 1278073005473 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1278073005474 Condensation domain; Region: Condensation; pfam00668 1278073005475 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073005476 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073005477 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 1278073005478 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 1278073005479 HEAT repeats; Region: HEAT_2; pfam13646 1278073005480 Glycosyl hydrolase family 45; Region: Glyco_hydro_45; pfam02015 1278073005481 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 1278073005482 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 1278073005483 acyl-CoA synthetase; Validated; Region: PRK05850 1278073005484 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1278073005485 acyl-activating enzyme (AAE) consensus motif; other site 1278073005486 active site 1278073005487 H+ Antiporter protein; Region: 2A0121; TIGR00900 1278073005488 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1278073005489 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073005490 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073005491 acyl-activating enzyme (AAE) consensus motif; other site 1278073005492 AMP binding site [chemical binding]; other site 1278073005493 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073005494 Condensation domain; Region: Condensation; pfam00668 1278073005495 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073005496 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073005497 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073005498 acyl-activating enzyme (AAE) consensus motif; other site 1278073005499 AMP binding site [chemical binding]; other site 1278073005500 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073005501 Condensation domain; Region: Condensation; pfam00668 1278073005502 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073005503 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1278073005504 acyl-activating enzyme (AAE) consensus motif; other site 1278073005505 AMP binding site [chemical binding]; other site 1278073005506 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073005507 Condensation domain; Region: Condensation; pfam00668 1278073005508 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073005509 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073005510 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073005511 acyl-activating enzyme (AAE) consensus motif; other site 1278073005512 AMP binding site [chemical binding]; other site 1278073005513 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073005514 Condensation domain; Region: Condensation; pfam00668 1278073005515 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073005516 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1278073005517 Condensation domain; Region: Condensation; pfam00668 1278073005518 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073005519 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073005520 acyl-activating enzyme (AAE) consensus motif; other site 1278073005521 AMP binding site [chemical binding]; other site 1278073005522 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073005523 Condensation domain; Region: Condensation; pfam00668 1278073005524 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073005525 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073005526 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 1278073005527 acyl-activating enzyme (AAE) consensus motif; other site 1278073005528 AMP binding site [chemical binding]; other site 1278073005529 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073005530 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1278073005531 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1278073005532 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073005533 active site 1278073005534 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1278073005535 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1278073005536 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073005537 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 1278073005538 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1278073005539 inhibitor-cofactor binding pocket; inhibition site 1278073005540 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1278073005541 catalytic residue [active] 1278073005542 Condensation domain; Region: Condensation; pfam00668 1278073005543 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073005544 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073005545 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073005546 acyl-activating enzyme (AAE) consensus motif; other site 1278073005547 AMP binding site [chemical binding]; other site 1278073005548 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073005549 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1278073005550 Amidinotransferase; Region: Amidinotransf; cl12043 1278073005551 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1278073005552 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1278073005553 DNA binding residues [nucleotide binding] 1278073005554 dimerization interface [polypeptide binding]; other site 1278073005555 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 1278073005556 putative diguanylate cyclase; Provisional; Region: PRK09776 1278073005557 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 1278073005558 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073005559 Walker A/P-loop; other site 1278073005560 ATP binding site [chemical binding]; other site 1278073005561 Q-loop/lid; other site 1278073005562 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1278073005563 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073005564 Walker A/P-loop; other site 1278073005565 ATP binding site [chemical binding]; other site 1278073005566 Q-loop/lid; other site 1278073005567 ABC transporter signature motif; other site 1278073005568 Walker B; other site 1278073005569 D-loop; other site 1278073005570 H-loop/switch region; other site 1278073005571 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1278073005572 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1278073005573 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1278073005574 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1278073005575 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1278073005576 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1278073005577 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1278073005578 Condensation domain; Region: Condensation; pfam00668 1278073005579 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073005580 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073005581 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073005582 acyl-activating enzyme (AAE) consensus motif; other site 1278073005583 AMP binding site [chemical binding]; other site 1278073005584 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073005585 Condensation domain; Region: Condensation; pfam00668 1278073005586 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1278073005587 Condensation domain; Region: Condensation; pfam00668 1278073005588 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073005589 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073005590 acyl-activating enzyme (AAE) consensus motif; other site 1278073005591 AMP binding site [chemical binding]; other site 1278073005592 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073005593 Condensation domain; Region: Condensation; pfam00668 1278073005594 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073005595 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073005596 acyl-activating enzyme (AAE) consensus motif; other site 1278073005597 AMP binding site [chemical binding]; other site 1278073005598 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073005599 Condensation domain; Region: Condensation; pfam00668 1278073005600 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073005601 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073005602 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073005603 acyl-activating enzyme (AAE) consensus motif; other site 1278073005604 AMP binding site [chemical binding]; other site 1278073005605 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073005606 peptide synthase; Provisional; Region: PRK12467 1278073005607 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073005608 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073005609 acyl-activating enzyme (AAE) consensus motif; other site 1278073005610 AMP binding site [chemical binding]; other site 1278073005611 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073005612 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073005613 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073005614 acyl-activating enzyme (AAE) consensus motif; other site 1278073005615 AMP binding site [chemical binding]; other site 1278073005616 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073005617 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1278073005618 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1278073005619 acyl-activating enzyme (AAE) consensus motif; other site 1278073005620 AMP binding site [chemical binding]; other site 1278073005621 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073005622 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073005623 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073005624 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073005625 acyl-activating enzyme (AAE) consensus motif; other site 1278073005626 AMP binding site [chemical binding]; other site 1278073005627 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073005628 Condensation domain; Region: Condensation; pfam00668 1278073005629 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073005630 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073005631 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1278073005632 acyl-activating enzyme (AAE) consensus motif; other site 1278073005633 AMP binding site [chemical binding]; other site 1278073005634 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073005635 Condensation domain; Region: Condensation; pfam00668 1278073005636 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073005637 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073005638 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1278073005639 CoA binding site [chemical binding]; other site 1278073005640 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073005641 Condensation domain; Region: Condensation; pfam00668 1278073005642 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073005643 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073005644 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073005645 acyl-activating enzyme (AAE) consensus motif; other site 1278073005646 AMP binding site [chemical binding]; other site 1278073005647 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073005648 Condensation domain; Region: Condensation; pfam00668 1278073005649 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073005650 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073005651 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073005652 acyl-activating enzyme (AAE) consensus motif; other site 1278073005653 AMP binding site [chemical binding]; other site 1278073005654 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073005655 Condensation domain; Region: Condensation; pfam00668 1278073005656 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073005657 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073005658 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073005659 acyl-activating enzyme (AAE) consensus motif; other site 1278073005660 AMP binding site [chemical binding]; other site 1278073005661 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073005662 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1278073005663 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073005664 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073005665 acyl-activating enzyme (AAE) consensus motif; other site 1278073005666 AMP binding site [chemical binding]; other site 1278073005667 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073005668 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1278073005669 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1278073005670 TAP-like protein; Region: Abhydrolase_4; pfam08386 1278073005671 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; pfam13930 1278073005672 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1278073005673 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1278073005674 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073005675 active site 1278073005676 phosphorylation site [posttranslational modification] 1278073005677 intermolecular recognition site; other site 1278073005678 dimerization interface [polypeptide binding]; other site 1278073005679 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1278073005680 DNA binding site [nucleotide binding] 1278073005681 sensor protein RstB; Provisional; Region: PRK10604 1278073005682 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1278073005683 dimerization interface [polypeptide binding]; other site 1278073005684 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1278073005685 dimer interface [polypeptide binding]; other site 1278073005686 phosphorylation site [posttranslational modification] 1278073005687 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073005688 ATP binding site [chemical binding]; other site 1278073005689 Mg2+ binding site [ion binding]; other site 1278073005690 G-X-G motif; other site 1278073005691 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1278073005692 Beta-lactamase; Region: Beta-lactamase; pfam00144 1278073005693 SnoaL-like domain; Region: SnoaL_2; pfam12680 1278073005694 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1278073005695 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1278073005696 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 1278073005697 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 1278073005698 NAD-dependent deacetylase; Provisional; Region: PRK00481 1278073005699 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 1278073005700 NAD+ binding site [chemical binding]; other site 1278073005701 substrate binding site [chemical binding]; other site 1278073005702 Zn binding site [ion binding]; other site 1278073005703 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1278073005704 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1278073005705 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1278073005706 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1278073005707 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1278073005708 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1278073005709 active site 1278073005710 active site 1278073005711 Cupin; Region: Cupin_6; pfam12852 1278073005712 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1278073005713 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1278073005714 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1278073005715 FMN binding site [chemical binding]; other site 1278073005716 active site 1278073005717 substrate binding site [chemical binding]; other site 1278073005718 catalytic residue [active] 1278073005719 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1278073005720 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1278073005721 active site 1278073005722 dimerization interface [polypeptide binding]; other site 1278073005723 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1278073005724 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1278073005725 catalytic residues [active] 1278073005726 UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773 1278073005727 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1278073005728 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1278073005729 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1278073005730 Beta-lactamase; Region: Beta-lactamase; pfam00144 1278073005731 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1278073005732 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1278073005733 dimer interface [polypeptide binding]; other site 1278073005734 catalytic triad [active] 1278073005735 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 1278073005736 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 1278073005737 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1278073005738 HTH-like domain; Region: HTH_21; pfam13276 1278073005739 Integrase core domain; Region: rve; pfam00665 1278073005740 Integrase core domain; Region: rve_3; cl15866 1278073005741 putative transposase OrfB; Reviewed; Region: PHA02517 1278073005742 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1278073005743 Transposase; Region: HTH_Tnp_1; pfam01527 1278073005744 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1278073005745 Domain of unknown function (DUF4267); Region: DUF4267; pfam14087 1278073005746 Cupin; Region: Cupin_6; pfam12852 1278073005747 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1278073005748 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1278073005749 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1278073005750 Tyrosine kinase, catalytic domain; Region: TyrKc; smart00219 1278073005751 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073005752 active site 1278073005753 ATP binding site [chemical binding]; other site 1278073005754 substrate binding site [chemical binding]; other site 1278073005755 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1278073005756 substrate binding site [chemical binding]; other site 1278073005757 activation loop (A-loop); other site 1278073005758 activation loop (A-loop); other site 1278073005759 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1278073005760 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1278073005761 DNA-binding site [nucleotide binding]; DNA binding site 1278073005762 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1278073005763 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1278073005764 homodimer interface [polypeptide binding]; other site 1278073005765 catalytic residue [active] 1278073005766 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1278073005767 Interdomain contacts; other site 1278073005768 Cytokine receptor motif; other site 1278073005769 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1278073005770 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1278073005771 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1278073005772 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1278073005773 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1278073005774 minor groove reading motif; other site 1278073005775 helix-hairpin-helix signature motif; other site 1278073005776 substrate binding pocket [chemical binding]; other site 1278073005777 active site 1278073005778 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1278073005779 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1278073005780 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1278073005781 DNA binding site [nucleotide binding] 1278073005782 active site 1278073005783 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1278073005784 active site 1278073005785 ATP binding site [chemical binding]; other site 1278073005786 substrate binding site [chemical binding]; other site 1278073005787 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1278073005788 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 1278073005789 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073005790 Walker A/P-loop; other site 1278073005791 ATP binding site [chemical binding]; other site 1278073005792 Q-loop/lid; other site 1278073005793 ABC transporter signature motif; other site 1278073005794 Walker B; other site 1278073005795 D-loop; other site 1278073005796 H-loop/switch region; other site 1278073005797 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1278073005798 putative active site [active] 1278073005799 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1278073005800 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073005801 Walker A/P-loop; other site 1278073005802 ATP binding site [chemical binding]; other site 1278073005803 Q-loop/lid; other site 1278073005804 ABC transporter signature motif; other site 1278073005805 Walker B; other site 1278073005806 D-loop; other site 1278073005807 H-loop/switch region; other site 1278073005808 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1278073005809 HlyD family secretion protein; Region: HlyD_3; pfam13437 1278073005810 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 1278073005811 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 1278073005812 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 1278073005813 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 1278073005814 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 1278073005815 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 1278073005816 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1278073005817 Predicted transcriptional regulator [Transcription]; Region: COG2378 1278073005818 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1278073005819 active site 1278073005820 Fungal fucose-specific lectin; Region: Fungal_lectin; pfam07938 1278073005821 Predicted transcriptional regulators [Transcription]; Region: COG1733 1278073005822 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1278073005823 putative DNA binding site [nucleotide binding]; other site 1278073005824 putative Zn2+ binding site [ion binding]; other site 1278073005825 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1278073005826 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488 1278073005827 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 1278073005828 Putative collagen-binding domain of a collagenase; Region: Collagen_bind_2; pfam12904 1278073005829 HEAT repeats; Region: HEAT_2; pfam13646 1278073005830 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1278073005831 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1278073005832 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1278073005833 dimerization interface [polypeptide binding]; other site 1278073005834 substrate binding pocket [chemical binding]; other site 1278073005835 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1278073005836 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1278073005837 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1278073005838 catalytic residue [active] 1278073005839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1278073005840 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1278073005841 putative substrate translocation pore; other site 1278073005842 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1278073005843 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1278073005844 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1278073005845 CHRD domain; Region: CHRD; cl06473 1278073005846 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1278073005847 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1278073005848 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1278073005849 dimerization interface [polypeptide binding]; other site 1278073005850 SnoaL-like domain; Region: SnoaL_3; pfam13474 1278073005851 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1278073005852 Beta-lactamase; Region: Beta-lactamase; pfam00144 1278073005853 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 1278073005854 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1278073005855 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1278073005856 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1278073005857 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1278073005858 conserved cys residue [active] 1278073005859 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1278073005860 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1278073005861 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 1278073005862 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1278073005863 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1278073005864 FtsX-like permease family; Region: FtsX; pfam02687 1278073005865 YCII-related domain; Region: YCII; cl00999 1278073005866 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1278073005867 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1278073005868 active site 1278073005869 substrate binding site [chemical binding]; other site 1278073005870 trimer interface [polypeptide binding]; other site 1278073005871 CoA binding site [chemical binding]; other site 1278073005872 Condensation domain; Region: Condensation; pfam00668 1278073005873 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073005874 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073005875 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073005876 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073005877 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073005878 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073005879 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073005880 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073005881 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073005882 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073005883 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073005884 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073005885 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073005886 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073005887 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073005888 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073005889 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073005890 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073005891 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073005892 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073005893 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073005894 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073005895 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073005896 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073005897 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073005898 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073005899 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1278073005900 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1278073005901 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1278073005902 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1278073005903 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1278073005904 dimerization interface [polypeptide binding]; other site 1278073005905 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1278073005906 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1278073005907 Predicted membrane protein [Function unknown]; Region: COG2311 1278073005908 Protein of unknown function (DUF418); Region: DUF418; cl12135 1278073005909 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 1278073005910 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1278073005911 MAEBL; Provisional; Region: PTZ00121 1278073005912 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1278073005913 Predicted ATPase [General function prediction only]; Region: COG3911 1278073005914 AAA domain; Region: AAA_28; pfam13521 1278073005915 Dual-action HEIGH metallo-peptidase; Region: Peptidase_M57; pfam12388 1278073005916 Predicted transcriptional regulators [Transcription]; Region: COG1733 1278073005917 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1278073005918 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1278073005919 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1278073005920 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1278073005921 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 1278073005922 SLBB domain; Region: SLBB; pfam10531 1278073005923 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1278073005924 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073005925 binding surface 1278073005926 TPR motif; other site 1278073005927 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1278073005928 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073005929 TPR motif; other site 1278073005930 binding surface 1278073005931 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1278073005932 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073005933 TPR motif; other site 1278073005934 binding surface 1278073005935 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1278073005936 TPR repeat; Region: TPR_11; pfam13414 1278073005937 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073005938 binding surface 1278073005939 TPR motif; other site 1278073005940 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1278073005941 binding surface 1278073005942 TPR motif; other site 1278073005943 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1278073005944 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073005945 binding surface 1278073005946 TPR motif; other site 1278073005947 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1278073005948 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073005949 binding surface 1278073005950 TPR motif; other site 1278073005951 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 1278073005952 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1278073005953 G1 box; other site 1278073005954 GTP/Mg2+ binding site [chemical binding]; other site 1278073005955 G2 box; other site 1278073005956 Switch I region; other site 1278073005957 G3 box; other site 1278073005958 Switch II region; other site 1278073005959 G4 box; other site 1278073005960 G5 box; other site 1278073005961 Roadblock/LC7 domain; Region: Robl_LC7; pfam03259 1278073005962 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073005963 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1278073005964 FecR protein; Region: FecR; pfam04773 1278073005965 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073005966 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073005967 active site 1278073005968 ATP binding site [chemical binding]; other site 1278073005969 substrate binding site [chemical binding]; other site 1278073005970 activation loop (A-loop); other site 1278073005971 recombination protein RecR; Reviewed; Region: recR; PRK00076 1278073005972 RecR protein; Region: RecR; pfam02132 1278073005973 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1278073005974 putative active site [active] 1278073005975 putative metal-binding site [ion binding]; other site 1278073005976 tetramer interface [polypeptide binding]; other site 1278073005977 hypothetical protein; Validated; Region: PRK00153 1278073005978 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14965 1278073005979 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1278073005980 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073005981 Walker A motif; other site 1278073005982 ATP binding site [chemical binding]; other site 1278073005983 Walker B motif; other site 1278073005984 arginine finger; other site 1278073005985 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1278073005986 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1278073005987 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1278073005988 Alg9-like mannosyltransferase family; Region: Glyco_transf_22; cl17751 1278073005989 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1278073005990 nucleoside/Zn binding site; other site 1278073005991 dimer interface [polypeptide binding]; other site 1278073005992 catalytic motif [active] 1278073005993 seryl-tRNA synthetase; Provisional; Region: PRK05431 1278073005994 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1278073005995 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1278073005996 dimer interface [polypeptide binding]; other site 1278073005997 active site 1278073005998 motif 1; other site 1278073005999 motif 2; other site 1278073006000 motif 3; other site 1278073006001 zinc-ribbon domain; Region: zinc_ribbon_4; pfam13717 1278073006002 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1278073006003 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073006004 TPR motif; other site 1278073006005 binding surface 1278073006006 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073006007 binding surface 1278073006008 TPR motif; other site 1278073006009 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073006010 TPR motif; other site 1278073006011 binding surface 1278073006012 TPR repeat; Region: TPR_11; pfam13414 1278073006013 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073006014 binding surface 1278073006015 TPR motif; other site 1278073006016 TPR repeat; Region: TPR_11; pfam13414 1278073006017 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073006018 TPR motif; other site 1278073006019 binding surface 1278073006020 TPR repeat; Region: TPR_11; pfam13414 1278073006021 Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232 1278073006022 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1278073006023 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1278073006024 Ligand binding site; other site 1278073006025 Putative Catalytic site; other site 1278073006026 DXD motif; other site 1278073006027 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1278073006028 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1278073006029 Lipase (class 2); Region: Lipase_2; pfam01674 1278073006030 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1278073006031 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1278073006032 putative acyl-acceptor binding pocket; other site 1278073006033 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1278073006034 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 1278073006035 putative NAD(P) binding site [chemical binding]; other site 1278073006036 active site 1278073006037 putative substrate binding site [chemical binding]; other site 1278073006038 TPR repeat; Region: TPR_11; pfam13414 1278073006039 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073006040 binding surface 1278073006041 TPR motif; other site 1278073006042 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1278073006043 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1278073006044 TPR motif; other site 1278073006045 binding surface 1278073006046 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073006047 binding surface 1278073006048 TPR motif; other site 1278073006049 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073006050 TPR motif; other site 1278073006051 binding surface 1278073006052 TPR repeat; Region: TPR_11; pfam13414 1278073006053 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073006054 binding surface 1278073006055 TPR motif; other site 1278073006056 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1278073006057 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1278073006058 ATP binding site [chemical binding]; other site 1278073006059 putative Mg++ binding site [ion binding]; other site 1278073006060 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1278073006061 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1278073006062 nucleotide binding region [chemical binding]; other site 1278073006063 ATP-binding site [chemical binding]; other site 1278073006064 HRDC domain; Region: HRDC; pfam00570 1278073006065 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 1278073006066 hypothetical protein; Reviewed; Region: PRK00024 1278073006067 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1278073006068 MPN+ (JAMM) motif; other site 1278073006069 Zinc-binding site [ion binding]; other site 1278073006070 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1278073006071 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1278073006072 ligand binding site [chemical binding]; other site 1278073006073 flexible hinge region; other site 1278073006074 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1278073006075 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1278073006076 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1278073006077 O-succinylhomoserine sulfhydrylase; Validated; Region: PRK08133 1278073006078 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1278073006079 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1278073006080 catalytic residue [active] 1278073006081 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1278073006082 trimer interface [polypeptide binding]; other site 1278073006083 dimer interface [polypeptide binding]; other site 1278073006084 putative active site [active] 1278073006085 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1278073006086 dimer interface [polypeptide binding]; other site 1278073006087 ADP-ribose binding site [chemical binding]; other site 1278073006088 active site 1278073006089 nudix motif; other site 1278073006090 metal binding site [ion binding]; metal-binding site 1278073006091 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 1278073006092 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 1278073006093 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 1278073006094 CoA binding domain; Region: CoA_binding_2; pfam13380 1278073006095 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1278073006096 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1278073006097 active site 1278073006098 nucleophile elbow; other site 1278073006099 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1278073006100 dimerization interface [polypeptide binding]; other site 1278073006101 putative DNA binding site [nucleotide binding]; other site 1278073006102 putative Zn2+ binding site [ion binding]; other site 1278073006103 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073006104 S-adenosylmethionine binding site [chemical binding]; other site 1278073006105 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1278073006106 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 1278073006107 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1278073006108 substrate binding pocket [chemical binding]; other site 1278073006109 dimer interface [polypeptide binding]; other site 1278073006110 inhibitor binding site; inhibition site 1278073006111 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1278073006112 B12 binding site [chemical binding]; other site 1278073006113 cobalt ligand [ion binding]; other site 1278073006114 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1278073006115 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 1278073006116 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 1278073006117 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 1278073006118 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1278073006119 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1278073006120 minor groove reading motif; other site 1278073006121 helix-hairpin-helix signature motif; other site 1278073006122 substrate binding pocket [chemical binding]; other site 1278073006123 active site 1278073006124 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1278073006125 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1278073006126 DNA binding and oxoG recognition site [nucleotide binding] 1278073006127 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1278073006128 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073006129 NAD(P) binding site [chemical binding]; other site 1278073006130 active site 1278073006131 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1278073006132 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1278073006133 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1278073006134 Transposase domain (DUF772); Region: DUF772; pfam05598 1278073006135 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1278073006136 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1278073006137 putative ATP binding site [chemical binding]; other site 1278073006138 putative substrate interface [chemical binding]; other site 1278073006139 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1278073006140 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1278073006141 active site 1278073006142 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 1278073006143 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1278073006144 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1278073006145 Maf-like protein; Region: Maf; pfam02545 1278073006146 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1278073006147 active site 1278073006148 dimer interface [polypeptide binding]; other site 1278073006149 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073006150 binding surface 1278073006151 TPR motif; other site 1278073006152 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1278073006153 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1278073006154 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1278073006155 putative RNA binding site [nucleotide binding]; other site 1278073006156 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073006157 S-adenosylmethionine binding site [chemical binding]; other site 1278073006158 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 1278073006159 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1278073006160 Part of AAA domain; Region: AAA_19; pfam13245 1278073006161 Family description; Region: UvrD_C_2; pfam13538 1278073006162 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1278073006163 23S rRNA interface [nucleotide binding]; other site 1278073006164 L3 interface [polypeptide binding]; other site 1278073006165 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1278073006166 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1278073006167 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1278073006168 Walker A motif; other site 1278073006169 ATP binding site [chemical binding]; other site 1278073006170 Walker B motif; other site 1278073006171 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1278073006172 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 1278073006173 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073006174 binding surface 1278073006175 TPR repeat; Region: TPR_11; pfam13414 1278073006176 TPR motif; other site 1278073006177 TPR repeat; Region: TPR_11; pfam13414 1278073006178 TPR repeat; Region: TPR_11; pfam13414 1278073006179 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073006180 binding surface 1278073006181 TPR motif; other site 1278073006182 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1278073006183 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1278073006184 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1278073006185 phosphopeptide binding site; other site 1278073006186 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 1278073006187 selenophosphate synthetase; Provisional; Region: PRK00943 1278073006188 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1278073006189 dimerization interface [polypeptide binding]; other site 1278073006190 putative ATP binding site [chemical binding]; other site 1278073006191 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1278073006192 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1278073006193 active site 1278073006194 metal binding site [ion binding]; metal-binding site 1278073006195 ribonuclease PH; Reviewed; Region: rph; PRK00173 1278073006196 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1278073006197 hexamer interface [polypeptide binding]; other site 1278073006198 active site 1278073006199 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1278073006200 active site 1278073006201 dimerization interface [polypeptide binding]; other site 1278073006202 Family description; Region: VCBS; pfam13517 1278073006203 Family description; Region: VCBS; pfam13517 1278073006204 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 1278073006205 RecT family; Region: RecT; pfam03837 1278073006206 trigger factor; Region: tig; TIGR00115 1278073006207 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1278073006208 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1278073006209 Clp protease; Region: CLP_protease; pfam00574 1278073006210 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1278073006211 oligomer interface [polypeptide binding]; other site 1278073006212 active site residues [active] 1278073006213 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1278073006214 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1278073006215 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073006216 Walker A motif; other site 1278073006217 ATP binding site [chemical binding]; other site 1278073006218 Walker B motif; other site 1278073006219 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1278073006220 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1278073006221 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1278073006222 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1278073006223 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1278073006224 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1278073006225 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073006226 Walker A motif; other site 1278073006227 ATP binding site [chemical binding]; other site 1278073006228 Walker B motif; other site 1278073006229 arginine finger; other site 1278073006230 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1278073006231 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1278073006232 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1278073006233 peptide binding site [polypeptide binding]; other site 1278073006234 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1278073006235 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1278073006236 dimer interface [polypeptide binding]; other site 1278073006237 conserved gate region; other site 1278073006238 putative PBP binding loops; other site 1278073006239 ABC-ATPase subunit interface; other site 1278073006240 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1278073006241 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1278073006242 dimer interface [polypeptide binding]; other site 1278073006243 conserved gate region; other site 1278073006244 putative PBP binding loops; other site 1278073006245 ABC-ATPase subunit interface; other site 1278073006246 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073006247 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073006248 active site 1278073006249 phosphorylation site [posttranslational modification] 1278073006250 intermolecular recognition site; other site 1278073006251 dimerization interface [polypeptide binding]; other site 1278073006252 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 1278073006253 BolA-like protein; Region: BolA; pfam01722 1278073006254 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1278073006255 putative GSH binding site [chemical binding]; other site 1278073006256 catalytic residues [active] 1278073006257 Protein of unknown function (DUF2914); Region: DUF2914; pfam11141 1278073006258 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1278073006259 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 1278073006260 proline aminopeptidase P II; Provisional; Region: PRK10879 1278073006261 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1278073006262 active site 1278073006263 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1278073006264 RNA methyltransferase, RsmE family; Region: TIGR00046 1278073006265 DTW domain; Region: DTW; pfam03942 1278073006266 FecR protein; Region: FecR; pfam04773 1278073006267 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1278073006268 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073006269 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1278073006270 DNA binding residues [nucleotide binding] 1278073006271 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1278073006272 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073006273 S-adenosylmethionine binding site [chemical binding]; other site 1278073006274 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1278073006275 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1278073006276 substrate binding site [chemical binding]; other site 1278073006277 oxyanion hole (OAH) forming residues; other site 1278073006278 trimer interface [polypeptide binding]; other site 1278073006279 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 1278073006280 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1278073006281 homodimer interface [polypeptide binding]; other site 1278073006282 substrate-cofactor binding pocket; other site 1278073006283 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1278073006284 catalytic residue [active] 1278073006285 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 1278073006286 trimer interface [polypeptide binding]; other site 1278073006287 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 1278073006288 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 1278073006289 putative active site [active] 1278073006290 putative catalytic site [active] 1278073006291 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1278073006292 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1278073006293 tetramer interface [polypeptide binding]; other site 1278073006294 active site 1278073006295 Mg2+/Mn2+ binding site [ion binding]; other site 1278073006296 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 1278073006297 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1278073006298 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1278073006299 DNA binding site [nucleotide binding] 1278073006300 active site 1278073006301 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1278073006302 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1278073006303 AlkA N-terminal domain; Region: AlkA_N; pfam06029 1278073006304 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 1278073006305 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1278073006306 minor groove reading motif; other site 1278073006307 helix-hairpin-helix signature motif; other site 1278073006308 substrate binding pocket [chemical binding]; other site 1278073006309 active site 1278073006310 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 1278073006311 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1278073006312 dimer interface [polypeptide binding]; other site 1278073006313 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1278073006314 catalytic residue [active] 1278073006315 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 1278073006316 Phosphotransferase enzyme family; Region: APH; pfam01636 1278073006317 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1278073006318 substrate binding site [chemical binding]; other site 1278073006319 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1278073006320 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 1278073006321 Substrate binding site; other site 1278073006322 metal-binding site 1278073006323 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1278073006324 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1278073006325 active site 1278073006326 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 1278073006327 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1278073006328 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1278073006329 HSP70 interaction site [polypeptide binding]; other site 1278073006330 TPR repeat; Region: TPR_11; pfam13414 1278073006331 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073006332 binding surface 1278073006333 TPR motif; other site 1278073006334 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073006335 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073006336 active site 1278073006337 phosphorylation site [posttranslational modification] 1278073006338 intermolecular recognition site; other site 1278073006339 dimerization interface [polypeptide binding]; other site 1278073006340 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 1278073006341 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073006342 binding surface 1278073006343 TPR motif; other site 1278073006344 UGMP family protein; Validated; Region: PRK09604 1278073006345 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1278073006346 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1278073006347 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073006348 S-adenosylmethionine binding site [chemical binding]; other site 1278073006349 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1278073006350 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1278073006351 Substrate-binding site [chemical binding]; other site 1278073006352 Substrate specificity [chemical binding]; other site 1278073006353 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1278073006354 oligomerization interface [polypeptide binding]; other site 1278073006355 active site 1278073006356 metal binding site [ion binding]; metal-binding site 1278073006357 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1278073006358 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1278073006359 active site 1278073006360 ATP-binding site [chemical binding]; other site 1278073006361 pantoate-binding site; other site 1278073006362 HXXH motif; other site 1278073006363 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1278073006364 SmpB-tmRNA interface; other site 1278073006365 Stringent starvation protein B; Region: SspB; cl01120 1278073006366 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073006367 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073006368 active site 1278073006369 ATP binding site [chemical binding]; other site 1278073006370 substrate binding site [chemical binding]; other site 1278073006371 activation loop (A-loop); other site 1278073006372 PEGA domain; Region: PEGA; pfam08308 1278073006373 Protein of unknown function (DUF971); Region: DUF971; pfam06155 1278073006374 Cache domain; Region: Cache_1; pfam02743 1278073006375 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1278073006376 dimerization interface [polypeptide binding]; other site 1278073006377 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1278073006378 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1278073006379 Zn2+ binding site [ion binding]; other site 1278073006380 Mg2+ binding site [ion binding]; other site 1278073006381 FecR protein; Region: FecR; pfam04773 1278073006382 nitrilase; Region: PLN02798 1278073006383 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 1278073006384 putative active site [active] 1278073006385 catalytic triad [active] 1278073006386 dimer interface [polypeptide binding]; other site 1278073006387 Sm and related proteins; Region: Sm_like; cl00259 1278073006388 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1278073006389 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1278073006390 putative oligomer interface [polypeptide binding]; other site 1278073006391 putative RNA binding site [nucleotide binding]; other site 1278073006392 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1278073006393 NusA N-terminal domain; Region: NusA_N; pfam08529 1278073006394 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1278073006395 RNA binding site [nucleotide binding]; other site 1278073006396 homodimer interface [polypeptide binding]; other site 1278073006397 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1278073006398 G-X-X-G motif; other site 1278073006399 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1278073006400 G-X-X-G motif; other site 1278073006401 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1278073006402 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1278073006403 putative RNA binding cleft [nucleotide binding]; other site 1278073006404 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1278073006405 translation initiation factor IF-2; Region: IF-2; TIGR00487 1278073006406 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1278073006407 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1278073006408 G1 box; other site 1278073006409 putative GEF interaction site [polypeptide binding]; other site 1278073006410 GTP/Mg2+ binding site [chemical binding]; other site 1278073006411 Switch I region; other site 1278073006412 G2 box; other site 1278073006413 G3 box; other site 1278073006414 Switch II region; other site 1278073006415 G4 box; other site 1278073006416 G5 box; other site 1278073006417 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1278073006418 Translation-initiation factor 2; Region: IF-2; pfam11987 1278073006419 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1278073006420 Protein of unknown function (DUF503); Region: DUF503; pfam04456 1278073006421 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1278073006422 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 1278073006423 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1278073006424 RNA binding site [nucleotide binding]; other site 1278073006425 active site 1278073006426 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1278073006427 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1278073006428 16S/18S rRNA binding site [nucleotide binding]; other site 1278073006429 S13e-L30e interaction site [polypeptide binding]; other site 1278073006430 25S rRNA binding site [nucleotide binding]; other site 1278073006431 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1278073006432 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1278073006433 RNase E interface [polypeptide binding]; other site 1278073006434 trimer interface [polypeptide binding]; other site 1278073006435 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1278073006436 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1278073006437 RNase E interface [polypeptide binding]; other site 1278073006438 trimer interface [polypeptide binding]; other site 1278073006439 active site 1278073006440 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1278073006441 putative nucleic acid binding region [nucleotide binding]; other site 1278073006442 G-X-X-G motif; other site 1278073006443 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1278073006444 RNA binding site [nucleotide binding]; other site 1278073006445 domain interface; other site 1278073006446 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1278073006447 Peptidase family M23; Region: Peptidase_M23; pfam01551 1278073006448 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1278073006449 trimer interface [polypeptide binding]; other site 1278073006450 active site 1278073006451 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073006452 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073006453 active site 1278073006454 ATP binding site [chemical binding]; other site 1278073006455 substrate binding site [chemical binding]; other site 1278073006456 activation loop (A-loop); other site 1278073006457 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1278073006458 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1278073006459 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1278073006460 adenylosuccinate lyase; Provisional; Region: PRK07492 1278073006461 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1278073006462 tetramer interface [polypeptide binding]; other site 1278073006463 active site 1278073006464 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1278073006465 ATP binding site [chemical binding]; other site 1278073006466 active site 1278073006467 substrate binding site [chemical binding]; other site 1278073006468 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1278073006469 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1278073006470 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1278073006471 protein binding site [polypeptide binding]; other site 1278073006472 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1278073006473 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1278073006474 catalytic residues [active] 1278073006475 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1278073006476 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1278073006477 ligand binding site [chemical binding]; other site 1278073006478 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1278073006479 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1278073006480 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1278073006481 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1278073006482 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1278073006483 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1278073006484 Group XII secretory phospholipase A2 precursor (PLA2G12); Region: PLA2G12; pfam06951 1278073006485 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1278073006486 metal ion-dependent adhesion site (MIDAS); other site 1278073006487 Protein phosphatase 2C; Region: PP2C_2; pfam13672 1278073006488 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 1278073006489 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1278073006490 active site 1278073006491 ATP binding site [chemical binding]; other site 1278073006492 substrate binding site [chemical binding]; other site 1278073006493 activation loop (A-loop); other site 1278073006494 Bacterial SH3 domain; Region: SH3_3; cl17532 1278073006495 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1278073006496 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1278073006497 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1278073006498 ATP binding site [chemical binding]; other site 1278073006499 putative Mg++ binding site [ion binding]; other site 1278073006500 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1278073006501 nucleotide binding region [chemical binding]; other site 1278073006502 ATP-binding site [chemical binding]; other site 1278073006503 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1278073006504 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1278073006505 ATP-binding site [chemical binding]; other site 1278073006506 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1278073006507 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1278073006508 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1278073006509 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1278073006510 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1278073006511 DNA-binding site [nucleotide binding]; DNA binding site 1278073006512 RNA-binding motif; other site 1278073006513 AAA ATPase domain; Region: AAA_16; pfam13191 1278073006514 AAA domain; Region: AAA_22; pfam13401 1278073006515 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073006516 Protein kinase domain; Region: Pkinase; pfam00069 1278073006517 active site 1278073006518 ATP binding site [chemical binding]; other site 1278073006519 substrate binding site [chemical binding]; other site 1278073006520 activation loop (A-loop); other site 1278073006521 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1278073006522 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1278073006523 Catalytic site [active] 1278073006524 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1278073006525 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 1278073006526 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073006527 DNA binding residues [nucleotide binding] 1278073006528 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1278073006529 Caspase domain; Region: Peptidase_C14; pfam00656 1278073006530 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 1278073006531 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1278073006532 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 1278073006533 putative dimer interface [polypeptide binding]; other site 1278073006534 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1278073006535 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1278073006536 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1278073006537 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1278073006538 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1278073006539 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1278073006540 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1278073006541 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1278073006542 Uncharacterized conserved protein (DUF2181); Region: DUF2181; pfam10223 1278073006543 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 1278073006544 Domain of unknown function (DUF3291); Region: DUF3291; pfam11695 1278073006545 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4460 1278073006546 tyrosine decarboxylase; Region: PLN02880 1278073006547 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1278073006548 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1278073006549 catalytic residue [active] 1278073006550 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1278073006551 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1278073006552 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1278073006553 putative di-iron ligands [ion binding]; other site 1278073006554 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1278073006555 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 1278073006556 active site 1 [active] 1278073006557 dimer interface [polypeptide binding]; other site 1278073006558 hexamer interface [polypeptide binding]; other site 1278073006559 active site 2 [active] 1278073006560 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 1278073006561 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1278073006562 ATP binding site [chemical binding]; other site 1278073006563 putative Mg++ binding site [ion binding]; other site 1278073006564 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1278073006565 nucleotide binding region [chemical binding]; other site 1278073006566 ATP-binding site [chemical binding]; other site 1278073006567 Helicase associated domain (HA2); Region: HA2; pfam04408 1278073006568 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1278073006569 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1278073006570 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1278073006571 Helix-turn-helix domain; Region: HTH_18; pfam12833 1278073006572 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1278073006573 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1278073006574 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073006575 binding surface 1278073006576 TPR motif; other site 1278073006577 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1278073006578 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1278073006579 CoenzymeA binding site [chemical binding]; other site 1278073006580 subunit interaction site [polypeptide binding]; other site 1278073006581 PHB binding site; other site 1278073006582 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 1278073006583 Cytochrome c; Region: Cytochrom_C; pfam00034 1278073006584 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 1278073006585 Uncharacterized protein family (UPF0259); Region: UPF0259; cl11642 1278073006586 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 1278073006587 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 1278073006588 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1278073006589 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1278073006590 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1278073006591 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1278073006592 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1278073006593 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464 1278073006594 putative substrate binding pocket [chemical binding]; other site 1278073006595 putative dimerization interface [polypeptide binding]; other site 1278073006596 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1278073006597 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1278073006598 active site 1278073006599 catalytic tetrad [active] 1278073006600 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1278073006601 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1278073006602 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1278073006603 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1278073006604 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073006605 von Willebrand factor; Region: vWF_A; pfam12450 1278073006606 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1278073006607 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 1278073006608 metal ion-dependent adhesion site (MIDAS); other site 1278073006609 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 1278073006610 Winged helix-turn helix; Region: HTH_29; pfam13551 1278073006611 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073006612 binding surface 1278073006613 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1278073006614 TPR motif; other site 1278073006615 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1278073006616 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1278073006617 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073006618 S-adenosylmethionine binding site [chemical binding]; other site 1278073006619 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1278073006620 Predicted transcriptional regulators [Transcription]; Region: COG1378 1278073006621 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 1278073006622 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 1278073006623 C-terminal domain interface [polypeptide binding]; other site 1278073006624 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 1278073006625 catalytic motif [active] 1278073006626 Catalytic residue [active] 1278073006627 Aspartyl protease; Region: Asp_protease_2; pfam13650 1278073006628 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1278073006629 protein binding site [polypeptide binding]; other site 1278073006630 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1278073006631 Coenzyme A binding pocket [chemical binding]; other site 1278073006632 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1278073006633 Protein of unknown function (DUF1428); Region: DUF1428; pfam07237 1278073006634 MarR family; Region: MarR; pfam01047 1278073006635 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1278073006636 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1278073006637 active site 1278073006638 catalytic tetrad [active] 1278073006639 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1278073006640 Kelch domain; Region: Kelch; smart00612 1278073006641 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1278073006642 Kelch motif; Region: Kelch_1; pfam01344 1278073006643 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1278073006644 Kelch domain; Region: Kelch; smart00612 1278073006645 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1278073006646 Kelch domain; Region: Kelch; smart00612 1278073006647 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1278073006648 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 1278073006649 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1278073006650 Kelch domain; Region: Kelch; smart00612 1278073006651 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1278073006652 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1278073006653 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1278073006654 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073006655 S-adenosylmethionine binding site [chemical binding]; other site 1278073006656 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 1278073006657 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 1278073006658 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1278073006659 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073006660 TPR motif; other site 1278073006661 binding surface 1278073006662 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 1278073006663 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1278073006664 potential catalytic triad [active] 1278073006665 conserved cys residue [active] 1278073006666 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1278073006667 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1278073006668 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073006669 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1278073006670 DNA binding residues [nucleotide binding] 1278073006671 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1278073006672 Protein of unknown function (DUF2378); Region: DUF2378; cl15288 1278073006673 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1278073006674 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073006675 NAD(P) binding site [chemical binding]; other site 1278073006676 active site 1278073006677 Peptidase M35 domain of peptidyl-Lys metalloendopeptidases; Region: M35_peptidyl-Lys; cd11306 1278073006678 active site 1278073006679 Zn binding site [ion binding]; other site 1278073006680 Peptidase M35 domain of peptidyl-Lys metalloendopeptidases; Region: M35_peptidyl-Lys; cd11306 1278073006681 active site 1278073006682 Zn binding site [ion binding]; other site 1278073006683 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1278073006684 active site 1278073006685 catalytic residues [active] 1278073006686 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 1278073006687 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 1278073006688 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 1278073006689 HEPN domain; Region: HEPN; cl00824 1278073006690 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 1278073006691 Phosphotransferase enzyme family; Region: APH; pfam01636 1278073006692 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1278073006693 HflX GTPase family; Region: HflX; cd01878 1278073006694 Ferrous iron transport protein B; Region: FeoB_N; pfam02421 1278073006695 G1 box; other site 1278073006696 GTP/Mg2+ binding site [chemical binding]; other site 1278073006697 Switch I region; other site 1278073006698 G2 box; other site 1278073006699 G3 box; other site 1278073006700 Switch II region; other site 1278073006701 G4 box; other site 1278073006702 G5 box; other site 1278073006703 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1278073006704 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1278073006705 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1278073006706 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1278073006707 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1278073006708 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1278073006709 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073006710 Condensation domain; Region: Condensation; pfam00668 1278073006711 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073006712 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073006713 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1278073006714 acyl-activating enzyme (AAE) consensus motif; other site 1278073006715 AMP binding site [chemical binding]; other site 1278073006716 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073006717 Condensation domain; Region: Condensation; pfam00668 1278073006718 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073006719 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073006720 AMP-binding enzyme; Region: AMP-binding; pfam00501 1278073006721 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1278073006722 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1278073006723 acyl-activating enzyme (AAE) consensus motif; other site 1278073006724 acyl-activating enzyme (AAE) consensus motif; other site 1278073006725 active site 1278073006726 AMP binding site [chemical binding]; other site 1278073006727 CoA binding site [chemical binding]; other site 1278073006728 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1278073006729 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1278073006730 dimer interface [polypeptide binding]; other site 1278073006731 active site 1278073006732 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1278073006733 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1278073006734 active site 1278073006735 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1278073006736 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 1278073006737 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1278073006738 catalytic residue [active] 1278073006739 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1278073006740 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1278073006741 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1278073006742 NAD(P) binding site [chemical binding]; other site 1278073006743 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1278073006744 putative active site [active] 1278073006745 putative catalytic site [active] 1278073006746 hypothetical protein; Provisional; Region: PRK07505 1278073006747 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1278073006748 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1278073006749 catalytic residue [active] 1278073006750 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1278073006751 Erythromycin esterase; Region: Erythro_esteras; cl17110 1278073006752 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 1278073006753 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1278073006754 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1278073006755 RNA ligase; Region: RNA_ligase; pfam09414 1278073006756 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 1278073006757 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 1278073006758 AsmA family; Region: AsmA; pfam05170 1278073006759 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1278073006760 Predicted peptidase [General function prediction only]; Region: COG4099 1278073006761 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 1278073006762 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 1278073006763 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 1278073006764 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1278073006765 Dual-action HEIGH metallo-peptidase; Region: Peptidase_M57; pfam12388 1278073006766 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1278073006767 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1278073006768 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1278073006769 Protein of unknown function (DUF3703); Region: DUF3703; pfam12487 1278073006770 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 1278073006771 PA/protease or protease-like domain interface [polypeptide binding]; other site 1278073006772 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1278073006773 Peptidase family M28; Region: Peptidase_M28; pfam04389 1278073006774 metal binding site [ion binding]; metal-binding site 1278073006775 Protein of unknown function, DUF488; Region: DUF488; cl01246 1278073006776 Carboxylesterase family; Region: COesterase; pfam00135 1278073006777 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1278073006778 substrate binding pocket [chemical binding]; other site 1278073006779 catalytic triad [active] 1278073006780 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1278073006781 Peptidase family M48; Region: Peptidase_M48; cl12018 1278073006782 Protein of unknown function (DUF1036); Region: DUF1036; cl02296 1278073006783 Peptide N-acetyl-beta-D-glucosaminyl asparaginase amidase A; Region: PNGaseA; pfam12222 1278073006784 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1278073006785 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1278073006786 HSP70 interaction site [polypeptide binding]; other site 1278073006787 Family description; Region: VCBS; pfam13517 1278073006788 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 1278073006789 metal binding site [ion binding]; metal-binding site 1278073006790 active site 1278073006791 Family description; Region: VCBS; pfam13517 1278073006792 Family description; Region: VCBS; pfam13517 1278073006793 HYR domain; Region: HYR; pfam02494 1278073006794 DinB superfamily; Region: DinB_2; pfam12867 1278073006795 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1278073006796 ATP binding site [chemical binding]; other site 1278073006797 putative Mg++ binding site [ion binding]; other site 1278073006798 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1278073006799 nucleotide binding region [chemical binding]; other site 1278073006800 ATP-binding site [chemical binding]; other site 1278073006801 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 1278073006802 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1278073006803 tetrameric interface [polypeptide binding]; other site 1278073006804 activator binding site; other site 1278073006805 NADP binding site [chemical binding]; other site 1278073006806 substrate binding site [chemical binding]; other site 1278073006807 catalytic residues [active] 1278073006808 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1278073006809 Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; Region: EGF_CA; cd00054 1278073006810 Ca2+ binding site [ion binding]; other site 1278073006811 Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; Region: EGF_CA; cd00054 1278073006812 Ca2+ binding site [ion binding]; other site 1278073006813 Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; Region: EGF_CA; cd00054 1278073006814 Ca2+ binding site [ion binding]; other site 1278073006815 Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; Region: EGF_CA; cd00054 1278073006816 Ca2+ binding site [ion binding]; other site 1278073006817 Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; Region: EGF_CA; cl09941 1278073006818 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 1278073006819 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 1278073006820 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 1278073006821 PEGA domain; Region: PEGA; pfam08308 1278073006822 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 1278073006823 conserved hypothetical protein; Region: TIGR02231 1278073006824 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 1278073006825 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 1278073006826 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073006827 NAD(P) binding site [chemical binding]; other site 1278073006828 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1278073006829 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073006830 active site 1278073006831 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 1278073006832 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 1278073006833 4-coumarate--CoA ligase-like; Region: PLN02574 1278073006834 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1278073006835 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 1278073006836 putative active site [active] 1278073006837 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1278073006838 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 1278073006839 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1278073006840 Leucine rich repeat; Region: LRR_8; pfam13855 1278073006841 Predicted membrane protein [Function unknown]; Region: COG1289 1278073006842 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1278073006843 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 1278073006844 active site 1278073006845 catalytic triad [active] 1278073006846 oxyanion hole [active] 1278073006847 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1278073006848 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1278073006849 putative di-iron ligands [ion binding]; other site 1278073006850 Cytochrome P450; Region: p450; cl12078 1278073006851 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1278073006852 PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and...; Region: PLAT; cd00113 1278073006853 Lipoxygenase; Region: Lipoxygenase; pfam00305 1278073006854 Transthyretin-like family; Region: DUF290; pfam01060 1278073006855 Lipoxygenase; Region: Lipoxygenase; pfam00305 1278073006856 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 1278073006857 recombination factor protein RarA; Reviewed; Region: PRK13342 1278073006858 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073006859 Walker A motif; other site 1278073006860 ATP binding site [chemical binding]; other site 1278073006861 Walker B motif; other site 1278073006862 arginine finger; other site 1278073006863 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1278073006864 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1278073006865 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073006866 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 1278073006867 aldehyde dehydrogenase family 7 member; Region: PLN02315 1278073006868 NAD+-dependent alpha-aminoadipic semialdehyde dehydrogenase, ALDH family members 7A1 and 7B; Region: ALDH_F7_AASADH; cd07130 1278073006869 tetrameric interface [polypeptide binding]; other site 1278073006870 NAD binding site [chemical binding]; other site 1278073006871 catalytic residues [active] 1278073006872 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1278073006873 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1278073006874 dimerization interface [polypeptide binding]; other site 1278073006875 substrate binding pocket [chemical binding]; other site 1278073006876 EamA-like transporter family; Region: EamA; pfam00892 1278073006877 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1278073006878 EamA-like transporter family; Region: EamA; pfam00892 1278073006879 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073006880 S-adenosylmethionine binding site [chemical binding]; other site 1278073006881 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1278073006882 RNA/DNA hybrid binding site [nucleotide binding]; other site 1278073006883 active site 1278073006884 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1278073006885 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1278073006886 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1278073006887 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 1278073006888 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 1278073006889 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 1278073006890 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1278073006891 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1278073006892 Walker A/P-loop; other site 1278073006893 ATP binding site [chemical binding]; other site 1278073006894 Q-loop/lid; other site 1278073006895 ABC transporter signature motif; other site 1278073006896 Walker B; other site 1278073006897 D-loop; other site 1278073006898 H-loop/switch region; other site 1278073006899 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1278073006900 putative active site [active] 1278073006901 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1278073006902 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073006903 Walker A/P-loop; other site 1278073006904 ATP binding site [chemical binding]; other site 1278073006905 Q-loop/lid; other site 1278073006906 ABC transporter signature motif; other site 1278073006907 Walker B; other site 1278073006908 D-loop; other site 1278073006909 H-loop/switch region; other site 1278073006910 HlyD family secretion protein; Region: HlyD_3; pfam13437 1278073006911 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1278073006912 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1278073006913 putative effector binding pocket; other site 1278073006914 dimerization interface [polypeptide binding]; other site 1278073006915 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1278073006916 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1278073006917 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1278073006918 Leucine-rich repeats; other site 1278073006919 Substrate binding site [chemical binding]; other site 1278073006920 Leucine rich repeat; Region: LRR_8; pfam13855 1278073006921 Leucine rich repeat; Region: LRR_8; pfam13855 1278073006922 PilZ domain; Region: PilZ; cl01260 1278073006923 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1278073006924 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1278073006925 putative amidase; Provisional; Region: PRK06169 1278073006926 Amidase; Region: Amidase; cl11426 1278073006927 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1278073006928 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 1278073006929 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241 1278073006930 putative active site [active] 1278073006931 Zn binding site [ion binding]; other site 1278073006932 Histidine kinase; Region: His_kinase; pfam06580 1278073006933 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073006934 Mg2+ binding site [ion binding]; other site 1278073006935 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1278073006936 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073006937 active site 1278073006938 phosphorylation site [posttranslational modification] 1278073006939 intermolecular recognition site; other site 1278073006940 dimerization interface [polypeptide binding]; other site 1278073006941 LytTr DNA-binding domain; Region: LytTR; smart00850 1278073006942 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1278073006943 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1278073006944 substrate binding pocket [chemical binding]; other site 1278073006945 membrane-bound complex binding site; other site 1278073006946 GTPase RsgA; Reviewed; Region: PRK01889 1278073006947 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1278073006948 RNA binding site [nucleotide binding]; other site 1278073006949 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1278073006950 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1278073006951 GTP/Mg2+ binding site [chemical binding]; other site 1278073006952 G4 box; other site 1278073006953 G5 box; other site 1278073006954 G1 box; other site 1278073006955 Switch I region; other site 1278073006956 G2 box; other site 1278073006957 G3 box; other site 1278073006958 Switch II region; other site 1278073006959 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1278073006960 PAS domain; Region: PAS_9; pfam13426 1278073006961 putative active site [active] 1278073006962 heme pocket [chemical binding]; other site 1278073006963 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1278073006964 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1278073006965 putative active site [active] 1278073006966 heme pocket [chemical binding]; other site 1278073006967 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1278073006968 putative active site [active] 1278073006969 heme pocket [chemical binding]; other site 1278073006970 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1278073006971 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1278073006972 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073006973 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073006974 dimer interface [polypeptide binding]; other site 1278073006975 phosphorylation site [posttranslational modification] 1278073006976 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073006977 ATP binding site [chemical binding]; other site 1278073006978 Mg2+ binding site [ion binding]; other site 1278073006979 G-X-G motif; other site 1278073006980 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 1278073006981 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1278073006982 nucleotide binding site [chemical binding]; other site 1278073006983 substrate binding site [chemical binding]; other site 1278073006984 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 1278073006985 dimer interface [polypeptide binding]; other site 1278073006986 putative threonine allosteric regulatory site; other site 1278073006987 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 1278073006988 putative threonine allosteric regulatory site; other site 1278073006989 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1278073006990 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1278073006991 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1278073006992 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1278073006993 phosphopeptide binding site; other site 1278073006994 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1278073006995 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1278073006996 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1278073006997 cyclase homology domain; Region: CHD; cd07302 1278073006998 nucleotidyl binding site; other site 1278073006999 metal binding site [ion binding]; metal-binding site 1278073007000 dimer interface [polypeptide binding]; other site 1278073007001 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1278073007002 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1278073007003 conserved cys residue [active] 1278073007004 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1278073007005 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1278073007006 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1278073007007 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1278073007008 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1278073007009 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1278073007010 catalytic residues [active] 1278073007011 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1278073007012 LysR family transcriptional regulator; Provisional; Region: PRK14997 1278073007013 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1278073007014 putative effector binding pocket; other site 1278073007015 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1278073007016 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1278073007017 FMN binding site [chemical binding]; other site 1278073007018 active site 1278073007019 catalytic residues [active] 1278073007020 substrate binding site [chemical binding]; other site 1278073007021 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 1278073007022 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1278073007023 CGNR zinc finger; Region: zf-CGNR; pfam11706 1278073007024 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 1278073007025 active site 1278073007026 Mn binding site [ion binding]; other site 1278073007027 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073007028 TPR motif; other site 1278073007029 binding surface 1278073007030 TPR repeat; Region: TPR_11; pfam13414 1278073007031 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073007032 binding surface 1278073007033 TPR motif; other site 1278073007034 TPR repeat; Region: TPR_11; pfam13414 1278073007035 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1278073007036 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1278073007037 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1278073007038 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1278073007039 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1278073007040 active site 1278073007041 Zn binding site [ion binding]; other site 1278073007042 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1278073007043 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1278073007044 Interdomain contacts; other site 1278073007045 Cytokine receptor motif; other site 1278073007046 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1278073007047 Glyco_18 domain; Region: Glyco_18; smart00636 1278073007048 active site 1278073007049 hypothetical protein; Provisional; Region: PRK08262 1278073007050 M20 Peptidase, carboxypeptidase yscS; Region: M20_yscS; cd05674 1278073007051 metal binding site [ion binding]; metal-binding site 1278073007052 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1278073007053 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1278073007054 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 1278073007055 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1278073007056 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 1278073007057 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1278073007058 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 1278073007059 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1278073007060 PA14 domain; Region: PA14; cl08459 1278073007061 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1278073007062 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073007063 TPR motif; other site 1278073007064 binding surface 1278073007065 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 1278073007066 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1278073007067 Kelch domain; Region: Kelch; smart00612 1278073007068 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1278073007069 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073007070 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073007071 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073007072 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073007073 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073007074 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073007075 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073007076 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073007077 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073007078 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073007079 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073007080 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073007081 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073007082 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073007083 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073007084 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073007085 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073007086 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073007087 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073007088 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073007089 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073007090 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073007091 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073007092 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073007093 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073007094 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073007095 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1278073007096 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 1278073007097 putative dimer interface [polypeptide binding]; other site 1278073007098 putative anticodon binding site; other site 1278073007099 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1278073007100 homodimer interface [polypeptide binding]; other site 1278073007101 motif 1; other site 1278073007102 motif 2; other site 1278073007103 active site 1278073007104 motif 3; other site 1278073007105 CotH protein; Region: CotH; pfam08757 1278073007106 Protein of unknown function (DUF2743); Region: DUF2743; pfam10899 1278073007107 TonB C terminal; Region: TonB_2; pfam13103 1278073007108 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1278073007109 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1278073007110 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1278073007111 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1278073007112 Caspase domain; Region: Peptidase_C14; pfam00656 1278073007113 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 1278073007114 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1278073007115 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073007116 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1278073007117 DNA binding residues [nucleotide binding] 1278073007118 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 1278073007119 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 1278073007120 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1278073007121 ATP binding site [chemical binding]; other site 1278073007122 Mg++ binding site [ion binding]; other site 1278073007123 motif III; other site 1278073007124 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1278073007125 nucleotide binding region [chemical binding]; other site 1278073007126 ATP-binding site [chemical binding]; other site 1278073007127 PIN domain; Region: PIN_3; pfam13470 1278073007128 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 1278073007129 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1278073007130 putative NAD(P) binding site [chemical binding]; other site 1278073007131 RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248 1278073007132 ATP binding site [chemical binding]; other site 1278073007133 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 1278073007134 EF-hand domain pair; Region: EF_hand_5; pfam13499 1278073007135 Ca2+ binding site [ion binding]; other site 1278073007136 PAS fold; Region: PAS; pfam00989 1278073007137 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1278073007138 putative active site [active] 1278073007139 heme pocket [chemical binding]; other site 1278073007140 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1278073007141 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1278073007142 putative active site [active] 1278073007143 heme pocket [chemical binding]; other site 1278073007144 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073007145 dimer interface [polypeptide binding]; other site 1278073007146 phosphorylation site [posttranslational modification] 1278073007147 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073007148 ATP binding site [chemical binding]; other site 1278073007149 Mg2+ binding site [ion binding]; other site 1278073007150 G-X-G motif; other site 1278073007151 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1278073007152 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073007153 active site 1278073007154 phosphorylation site [posttranslational modification] 1278073007155 intermolecular recognition site; other site 1278073007156 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073007157 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073007158 active site 1278073007159 phosphorylation site [posttranslational modification] 1278073007160 intermolecular recognition site; other site 1278073007161 dimerization interface [polypeptide binding]; other site 1278073007162 Hpt domain; Region: Hpt; pfam01627 1278073007163 putative binding surface; other site 1278073007164 active site 1278073007165 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 1278073007166 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 1278073007167 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 1278073007168 Phosphodiesterase domain of human TDP2, a 5'-tyrosyl DNA phosphodiesterase, and related domains; Region: TDP2; cd09080 1278073007169 putative catalytic site [active] 1278073007170 putative metal binding site [ion binding]; other site 1278073007171 putative phosphate binding site [ion binding]; other site 1278073007172 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 1278073007173 Poly(A) polymerase central domain; Region: PAP_central; pfam04928 1278073007174 Nucleotidyltransferase (NT) domain of poly(A) polymerases and terminal uridylyl transferases; Region: NT_PAP_TUTase; cd05402 1278073007175 active site 1278073007176 putative primer-binding pocket; other site 1278073007177 metal binding triad [ion binding]; metal-binding site 1278073007178 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1278073007179 Surface antigen; Region: Bac_surface_Ag; pfam01103 1278073007180 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1278073007181 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1278073007182 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1278073007183 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1278073007184 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 1278073007185 pantothenate kinase; Provisional; Region: PRK05439 1278073007186 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1278073007187 ATP-binding site [chemical binding]; other site 1278073007188 CoA-binding site [chemical binding]; other site 1278073007189 Mg2+-binding site [ion binding]; other site 1278073007190 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1278073007191 NAD-dependent deacetylase; Provisional; Region: PRK05333 1278073007192 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 1278073007193 NAD+ binding site [chemical binding]; other site 1278073007194 substrate binding site [chemical binding]; other site 1278073007195 Zn binding site [ion binding]; other site 1278073007196 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1278073007197 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1278073007198 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1278073007199 dimerization interface [polypeptide binding]; other site 1278073007200 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1278073007201 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1278073007202 putative substrate translocation pore; other site 1278073007203 HD domain; Region: HD_3; pfam13023 1278073007204 sulfite reductase subunit beta; Provisional; Region: PRK13504 1278073007205 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1278073007206 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1278073007207 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 1278073007208 Flavodoxin; Region: Flavodoxin_1; pfam00258 1278073007209 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1278073007210 FAD binding pocket [chemical binding]; other site 1278073007211 FAD binding motif [chemical binding]; other site 1278073007212 catalytic residues [active] 1278073007213 NAD binding pocket [chemical binding]; other site 1278073007214 phosphate binding motif [ion binding]; other site 1278073007215 beta-alpha-beta structure motif; other site 1278073007216 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 1278073007217 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1278073007218 CysD dimerization site [polypeptide binding]; other site 1278073007219 G1 box; other site 1278073007220 putative GEF interaction site [polypeptide binding]; other site 1278073007221 GTP/Mg2+ binding site [chemical binding]; other site 1278073007222 Switch I region; other site 1278073007223 G2 box; other site 1278073007224 G3 box; other site 1278073007225 Switch II region; other site 1278073007226 G4 box; other site 1278073007227 G5 box; other site 1278073007228 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1278073007229 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1278073007230 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1278073007231 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1278073007232 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1278073007233 Active Sites [active] 1278073007234 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1278073007235 active site 1278073007236 SAM binding site [chemical binding]; other site 1278073007237 homodimer interface [polypeptide binding]; other site 1278073007238 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1278073007239 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1278073007240 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1278073007241 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1278073007242 Active Sites [active] 1278073007243 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1278073007244 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 1278073007245 phosphate binding site [ion binding]; other site 1278073007246 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 1278073007247 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1278073007248 active site 1278073007249 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 1278073007250 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1278073007251 CoA binding site [chemical binding]; other site 1278073007252 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073007253 Condensation domain; Region: Condensation; pfam00668 1278073007254 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073007255 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073007256 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073007257 acyl-activating enzyme (AAE) consensus motif; other site 1278073007258 AMP binding site [chemical binding]; other site 1278073007259 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073007260 Condensation domain; Region: Condensation; pfam00668 1278073007261 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073007262 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073007263 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1278073007264 acyl-activating enzyme (AAE) consensus motif; other site 1278073007265 AMP binding site [chemical binding]; other site 1278073007266 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073007267 Condensation domain; Region: Condensation; pfam00668 1278073007268 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073007269 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073007270 AMP binding site [chemical binding]; other site 1278073007271 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073007272 Condensation domain; Region: Condensation; pfam00668 1278073007273 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073007274 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073007275 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073007276 acyl-activating enzyme (AAE) consensus motif; other site 1278073007277 AMP binding site [chemical binding]; other site 1278073007278 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073007279 Condensation domain; Region: Condensation; pfam00668 1278073007280 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073007281 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073007282 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1278073007283 acyl-activating enzyme (AAE) consensus motif; other site 1278073007284 AMP binding site [chemical binding]; other site 1278073007285 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073007286 Condensation domain; Region: Condensation; pfam00668 1278073007287 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073007288 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073007289 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073007290 acyl-activating enzyme (AAE) consensus motif; other site 1278073007291 AMP binding site [chemical binding]; other site 1278073007292 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073007293 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1278073007294 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073007295 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1278073007296 acyl-activating enzyme (AAE) consensus motif; other site 1278073007297 AMP binding site [chemical binding]; other site 1278073007298 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073007299 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1278073007300 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1278073007301 Condensation domain; Region: Condensation; pfam00668 1278073007302 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073007303 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073007304 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1278073007305 acyl-activating enzyme (AAE) consensus motif; other site 1278073007306 AMP binding site [chemical binding]; other site 1278073007307 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073007308 Condensation domain; Region: Condensation; pfam00668 1278073007309 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073007310 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073007311 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1278073007312 acyl-activating enzyme (AAE) consensus motif; other site 1278073007313 CoA binding site [chemical binding]; other site 1278073007314 H+ Antiporter protein; Region: 2A0121; TIGR00900 1278073007315 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1278073007316 putative substrate translocation pore; other site 1278073007317 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1278073007318 dinuclear metal binding motif [ion binding]; other site 1278073007319 Protein of unknown function (DUF2378); Region: DUF2378; pfam09536 1278073007320 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1278073007321 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1278073007322 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1278073007323 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1278073007324 ligand binding site [chemical binding]; other site 1278073007325 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1278073007326 putative substrate translocation pore; other site 1278073007327 Helix-turn-helix domain; Region: HTH_18; pfam12833 1278073007328 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1278073007329 Atrophin-1 family; Region: Atrophin-1; pfam03154 1278073007330 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 1278073007331 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1278073007332 metal ion-dependent adhesion site (MIDAS); other site 1278073007333 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073007334 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073007335 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073007336 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073007337 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073007338 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073007339 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073007340 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073007341 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073007342 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073007343 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073007344 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073007345 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073007346 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073007347 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073007348 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073007349 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073007350 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073007351 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 1278073007352 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 1278073007353 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1278073007354 atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265 1278073007355 putative NAD(P) binding site [chemical binding]; other site 1278073007356 active site 1278073007357 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 1278073007358 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1278073007359 dimerization interface [polypeptide binding]; other site 1278073007360 ATP binding site [chemical binding]; other site 1278073007361 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1278073007362 dimerization interface [polypeptide binding]; other site 1278073007363 ATP binding site [chemical binding]; other site 1278073007364 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1278073007365 putative active site [active] 1278073007366 catalytic triad [active] 1278073007367 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1278073007368 SelR domain; Region: SelR; pfam01641 1278073007369 FOG: CBS domain [General function prediction only]; Region: COG0517 1278073007370 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1278073007371 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1278073007372 active site 1278073007373 dimer interface [polypeptide binding]; other site 1278073007374 motif 1; other site 1278073007375 motif 2; other site 1278073007376 motif 3; other site 1278073007377 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1278073007378 anticodon binding site; other site 1278073007379 OPT oligopeptide transporter protein; Region: OPT; cl14607 1278073007380 OPT oligopeptide transporter protein; Region: OPT; cl14607 1278073007381 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1278073007382 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1278073007383 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1278073007384 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1278073007385 catalytic residue [active] 1278073007386 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1278073007387 active site 1278073007388 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 1278073007389 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 1278073007390 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 1278073007391 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1278073007392 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1278073007393 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1278073007394 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1278073007395 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1278073007396 putative ADP-binding pocket [chemical binding]; other site 1278073007397 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1278073007398 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1278073007399 active site 1278073007400 HIGH motif; other site 1278073007401 nucleotide binding site [chemical binding]; other site 1278073007402 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1278073007403 KMSKS motif; other site 1278073007404 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1278073007405 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1278073007406 Beta-lactamase; Region: Beta-lactamase; pfam00144 1278073007407 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1278073007408 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073007409 active site 1278073007410 phosphorylation site [posttranslational modification] 1278073007411 intermolecular recognition site; other site 1278073007412 dimerization interface [polypeptide binding]; other site 1278073007413 LytTr DNA-binding domain; Region: LytTR; smart00850 1278073007414 Histidine kinase; Region: His_kinase; pfam06580 1278073007415 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 1278073007416 TAP-like protein; Region: Abhydrolase_4; pfam08386 1278073007417 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1278073007418 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 1278073007419 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1278073007420 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1278073007421 DNA binding residues [nucleotide binding] 1278073007422 dimerization interface [polypeptide binding]; other site 1278073007423 Methyltransferase domain; Region: Methyltransf_32; pfam13679 1278073007424 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 1278073007425 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 1278073007426 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 1278073007427 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1278073007428 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1278073007429 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1278073007430 active site 1278073007431 Zn binding site [ion binding]; other site 1278073007432 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1278073007433 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1278073007434 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1278073007435 Coenzyme A binding pocket [chemical binding]; other site 1278073007436 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1278073007437 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1278073007438 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1278073007439 active site 1278073007440 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 1278073007441 active site 1278073007442 SUMO-1 interface [polypeptide binding]; other site 1278073007443 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1278073007444 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1278073007445 putative substrate binding site [chemical binding]; other site 1278073007446 putative ATP binding site [chemical binding]; other site 1278073007447 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1278073007448 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1278073007449 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1278073007450 active site 1278073007451 Protein of unknown function (DUF423); Region: DUF423; pfam04241 1278073007452 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 1278073007453 Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168 1278073007454 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1278073007455 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1278073007456 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 1278073007457 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 1278073007458 active site 1278073007459 metal binding site [ion binding]; metal-binding site 1278073007460 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073007461 S-adenosylmethionine binding site [chemical binding]; other site 1278073007462 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1278073007463 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 1278073007464 Ligand binding site; other site 1278073007465 DXD motif; other site 1278073007466 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 1278073007467 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 1278073007468 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1278073007469 active site 1278073007470 phosphorylation site [posttranslational modification] 1278073007471 intermolecular recognition site; other site 1278073007472 dimerization interface [polypeptide binding]; other site 1278073007473 PAS domain S-box; Region: sensory_box; TIGR00229 1278073007474 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1278073007475 putative active site [active] 1278073007476 heme pocket [chemical binding]; other site 1278073007477 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1278073007478 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1278073007479 putative active site [active] 1278073007480 heme pocket [chemical binding]; other site 1278073007481 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073007482 dimer interface [polypeptide binding]; other site 1278073007483 phosphorylation site [posttranslational modification] 1278073007484 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073007485 ATP binding site [chemical binding]; other site 1278073007486 Mg2+ binding site [ion binding]; other site 1278073007487 G-X-G motif; other site 1278073007488 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073007489 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073007490 active site 1278073007491 phosphorylation site [posttranslational modification] 1278073007492 intermolecular recognition site; other site 1278073007493 dimerization interface [polypeptide binding]; other site 1278073007494 Protein of unknown function (DUF2378); Region: DUF2378; pfam09536 1278073007495 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1278073007496 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 1278073007497 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073007498 Walker A/P-loop; other site 1278073007499 ATP binding site [chemical binding]; other site 1278073007500 Q-loop/lid; other site 1278073007501 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073007502 ABC transporter signature motif; other site 1278073007503 Walker B; other site 1278073007504 D-loop; other site 1278073007505 H-loop/switch region; other site 1278073007506 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073007507 Walker A/P-loop; other site 1278073007508 ATP binding site [chemical binding]; other site 1278073007509 Q-loop/lid; other site 1278073007510 ABC transporter signature motif; other site 1278073007511 Walker B; other site 1278073007512 D-loop; other site 1278073007513 H-loop/switch region; other site 1278073007514 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1278073007515 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 1278073007516 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 1278073007517 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1278073007518 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073007519 Walker A/P-loop; other site 1278073007520 ATP binding site [chemical binding]; other site 1278073007521 Q-loop/lid; other site 1278073007522 ABC transporter signature motif; other site 1278073007523 Walker B; other site 1278073007524 D-loop; other site 1278073007525 H-loop/switch region; other site 1278073007526 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1278073007527 catalytic residues [active] 1278073007528 dimer interface [polypeptide binding]; other site 1278073007529 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 1278073007530 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1278073007531 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073007532 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1278073007533 Protein of unknown function (DUF2378); Region: DUF2378; cl15288 1278073007534 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1278073007535 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1278073007536 catalytic triad [active] 1278073007537 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073007538 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073007539 active site 1278073007540 ATP binding site [chemical binding]; other site 1278073007541 substrate binding site [chemical binding]; other site 1278073007542 activation loop (A-loop); other site 1278073007543 Protein of unknown function (DUF2381); Region: DUF2381; cl15442 1278073007544 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1278073007545 DNA methylase; Region: N6_N4_Mtase; pfam01555 1278073007546 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304 1278073007547 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1278073007548 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1278073007549 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 1278073007550 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1278073007551 oligopeptide transporter, OPT superfamily; Region: OPT_sfam; TIGR00728 1278073007552 OPT oligopeptide transporter protein; Region: OPT; pfam03169 1278073007553 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 1278073007554 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1278073007555 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1278073007556 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1278073007557 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073007558 Walker A/P-loop; other site 1278073007559 ATP binding site [chemical binding]; other site 1278073007560 Q-loop/lid; other site 1278073007561 ABC transporter signature motif; other site 1278073007562 Walker B; other site 1278073007563 D-loop; other site 1278073007564 H-loop/switch region; other site 1278073007565 ABC transporter; Region: ABC_tran_2; pfam12848 1278073007566 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1278073007567 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1278073007568 elongation factor G; Reviewed; Region: PRK12740 1278073007569 G1 box; other site 1278073007570 putative GEF interaction site [polypeptide binding]; other site 1278073007571 GTP/Mg2+ binding site [chemical binding]; other site 1278073007572 Switch I region; other site 1278073007573 G2 box; other site 1278073007574 G3 box; other site 1278073007575 Switch II region; other site 1278073007576 G4 box; other site 1278073007577 G5 box; other site 1278073007578 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091 1278073007579 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1278073007580 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_C; cd04097 1278073007581 SnoaL-like domain; Region: SnoaL_2; pfam12680 1278073007582 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1278073007583 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 1278073007584 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1278073007585 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1278073007586 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1278073007587 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1278073007588 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1278073007589 Right handed beta helix region; Region: Beta_helix; pfam13229 1278073007590 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1278073007591 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 1278073007592 RNA binding surface [nucleotide binding]; other site 1278073007593 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1278073007594 active site 1278073007595 uracil binding [chemical binding]; other site 1278073007596 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 1278073007597 cleavage site 1278073007598 active site 1278073007599 substrate binding sites [chemical binding]; other site 1278073007600 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 1278073007601 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1278073007602 Uncharacterized conserved protein [Function unknown]; Region: COG3342 1278073007603 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 1278073007604 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 1278073007605 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1278073007606 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1278073007607 MG2 domain; Region: A2M_N; pfam01835 1278073007608 Alpha-2-macroglobulin family; Region: A2M; pfam00207 1278073007609 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 1278073007610 surface patch; other site 1278073007611 thioester region; other site 1278073007612 specificity defining residues; other site 1278073007613 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 1278073007614 Transglycosylase; Region: Transgly; pfam00912 1278073007615 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1278073007616 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 1278073007617 CotH protein; Region: CotH; pfam08757 1278073007618 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1278073007619 Surface antigen; Region: Bac_surface_Ag; pfam01103 1278073007620 LVIVD repeat; Region: LVIVD; pfam08309 1278073007621 Uncharacterized conserved protein [Function unknown]; Region: COG5276 1278073007622 LVIVD repeat; Region: LVIVD; pfam08309 1278073007623 Vta1 like; Region: DUF605; pfam04652 1278073007624 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1278073007625 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1278073007626 FtsX-like permease family; Region: FtsX; pfam02687 1278073007627 FtsX-like permease family; Region: FtsX; pfam02687 1278073007628 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1278073007629 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1278073007630 Walker A/P-loop; other site 1278073007631 ATP binding site [chemical binding]; other site 1278073007632 Q-loop/lid; other site 1278073007633 ABC transporter signature motif; other site 1278073007634 Walker B; other site 1278073007635 D-loop; other site 1278073007636 H-loop/switch region; other site 1278073007637 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1278073007638 putative DNA binding site [nucleotide binding]; other site 1278073007639 putative Zn2+ binding site [ion binding]; other site 1278073007640 TPR repeat; Region: TPR_11; pfam13414 1278073007641 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073007642 binding surface 1278073007643 TPR motif; other site 1278073007644 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1278073007645 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 1278073007646 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073007647 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1278073007648 DNA binding residues [nucleotide binding] 1278073007649 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1278073007650 hypothetical protein; Provisional; Region: PRK09946 1278073007651 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 1278073007652 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1278073007653 Flagellar assembly protein FliH; Region: FliH; pfam02108 1278073007654 type III secretion apparatus H+-transporting two-sector ATPase; Region: III_secr_ATP; TIGR02546 1278073007655 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1278073007656 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1278073007657 Walker A motif/ATP binding site; other site 1278073007658 Walker B motif; other site 1278073007659 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1278073007660 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 1278073007661 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 1278073007662 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 1278073007663 FliP family; Region: FliP; cl00593 1278073007664 Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987 1278073007665 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1278073007666 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1278073007667 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1278073007668 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1278073007669 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 1278073007670 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073007671 binding surface 1278073007672 TPR motif; other site 1278073007673 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073007674 TPR motif; other site 1278073007675 binding surface 1278073007676 TPR repeat; Region: TPR_11; pfam13414 1278073007677 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 1278073007678 FHIPEP family; Region: FHIPEP; pfam00771 1278073007679 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1278073007680 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1278073007681 phosphopeptide binding site; other site 1278073007682 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1278073007683 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1278073007684 phosphopeptide binding site; other site 1278073007685 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073007686 TPR motif; other site 1278073007687 TPR repeat; Region: TPR_11; pfam13414 1278073007688 binding surface 1278073007689 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073007690 binding surface 1278073007691 TPR repeat; Region: TPR_11; pfam13414 1278073007692 TPR motif; other site 1278073007693 TPR repeat; Region: TPR_11; pfam13414 1278073007694 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073007695 binding surface 1278073007696 TPR motif; other site 1278073007697 RDD family; Region: RDD; pfam06271 1278073007698 HEAT repeats; Region: HEAT_2; pfam13646 1278073007699 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1278073007700 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1278073007701 ligand binding site [chemical binding]; other site 1278073007702 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1278073007703 active site 1278073007704 metal binding site [ion binding]; metal-binding site 1278073007705 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1278073007706 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1278073007707 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1278073007708 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073007709 binding surface 1278073007710 TPR motif; other site 1278073007711 Integral membrane protein DUF95; Region: DUF95; pfam01944 1278073007712 Inorganic pyrophosphatase; Region: Pyrophosphatase; pfam00719 1278073007713 dimer interface [polypeptide binding]; other site 1278073007714 metal binding sites [ion binding]; metal-binding site 1278073007715 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1278073007716 Protein of unknown function DUF58; Region: DUF58; pfam01882 1278073007717 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1278073007718 MoxR-like ATPases [General function prediction only]; Region: COG0714 1278073007719 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073007720 Walker A motif; other site 1278073007721 ATP binding site [chemical binding]; other site 1278073007722 Walker B motif; other site 1278073007723 arginine finger; other site 1278073007724 transcription termination factor Rho; Provisional; Region: PRK12608 1278073007725 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1278073007726 Walker A motif; other site 1278073007727 ATP binding site [chemical binding]; other site 1278073007728 Walker B motif; other site 1278073007729 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1278073007730 tandem repeat interface [polypeptide binding]; other site 1278073007731 oligomer interface [polypeptide binding]; other site 1278073007732 active site residues [active] 1278073007733 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1278073007734 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1278073007735 tandem repeat interface [polypeptide binding]; other site 1278073007736 oligomer interface [polypeptide binding]; other site 1278073007737 active site residues [active] 1278073007738 PEGA domain; Region: PEGA; pfam08308 1278073007739 PEGA domain; Region: PEGA; pfam08308 1278073007740 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1278073007741 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073007742 Mg2+ binding site [ion binding]; other site 1278073007743 G-X-G motif; other site 1278073007744 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1278073007745 anchoring element; other site 1278073007746 dimer interface [polypeptide binding]; other site 1278073007747 ATP binding site [chemical binding]; other site 1278073007748 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1278073007749 active site 1278073007750 putative metal-binding site [ion binding]; other site 1278073007751 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1278073007752 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1278073007753 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1278073007754 CAP-like domain; other site 1278073007755 active site 1278073007756 primary dimer interface [polypeptide binding]; other site 1278073007757 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1278073007758 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1278073007759 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073007760 NAD(P) binding site [chemical binding]; other site 1278073007761 active site 1278073007762 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1278073007763 Predicted peptidase [General function prediction only]; Region: COG4099 1278073007764 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 1278073007765 Peptidase S46; Region: Peptidase_S46; pfam10459 1278073007766 Bacteriophage peptidoglycan hydrolase; Region: Amidase_5; pfam05382 1278073007767 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1278073007768 High potential iron-sulfur protein; Region: HIPIP; pfam01355 1278073007769 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1278073007770 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1278073007771 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073007772 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1278073007773 DNA binding residues [nucleotide binding] 1278073007774 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1278073007775 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1278073007776 active site 1278073007777 metal binding site [ion binding]; metal-binding site 1278073007778 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1278073007779 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073007780 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073007781 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1278073007782 phosphopeptide binding site; other site 1278073007783 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1278073007784 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1278073007785 phosphopeptide binding site; other site 1278073007786 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1278073007787 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073007788 Walker A motif; other site 1278073007789 ATP binding site [chemical binding]; other site 1278073007790 Walker B motif; other site 1278073007791 arginine finger; other site 1278073007792 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1278073007793 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1278073007794 Type II secretion system (T2SS), protein M; Region: T2SM; cl01222 1278073007795 Competence protein A; Region: Competence_A; pfam11104 1278073007796 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1278073007797 PilX N-terminal; Region: PilX_N; pfam14341 1278073007798 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 1278073007799 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1278073007800 type II secretion system protein J; Region: gspJ; TIGR01711 1278073007801 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 1278073007802 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1278073007803 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1278073007804 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1278073007805 type II secretion system protein F; Region: GspF; TIGR02120 1278073007806 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1278073007807 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1278073007808 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1278073007809 type II secretion system protein E; Region: type_II_gspE; TIGR02533 1278073007810 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1278073007811 Walker A motif; other site 1278073007812 ATP binding site [chemical binding]; other site 1278073007813 Walker B motif; other site 1278073007814 type II secretion system protein D; Region: type_II_gspD; TIGR02517 1278073007815 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1278073007816 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1278073007817 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1278073007818 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1278073007819 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 1278073007820 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1278073007821 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1278073007822 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073007823 active site 1278073007824 phosphorylation site [posttranslational modification] 1278073007825 intermolecular recognition site; other site 1278073007826 dimerization interface [polypeptide binding]; other site 1278073007827 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073007828 Walker A motif; other site 1278073007829 ATP binding site [chemical binding]; other site 1278073007830 Walker B motif; other site 1278073007831 arginine finger; other site 1278073007832 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1278073007833 ParB-like nuclease domain; Region: ParB; smart00470 1278073007834 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1278073007835 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1278073007836 protease TldD; Provisional; Region: tldD; PRK10735 1278073007837 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1278073007838 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1278073007839 phosphopeptide binding site; other site 1278073007840 TPR repeat; Region: TPR_11; pfam13414 1278073007841 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073007842 binding surface 1278073007843 TPR motif; other site 1278073007844 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1278073007845 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1278073007846 ligand binding site [chemical binding]; other site 1278073007847 flexible hinge region; other site 1278073007848 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1278073007849 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1278073007850 ligand binding site [chemical binding]; other site 1278073007851 flexible hinge region; other site 1278073007852 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1278073007853 TPR motif; other site 1278073007854 binding surface 1278073007855 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073007856 TPR repeat; Region: TPR_11; pfam13414 1278073007857 TPR motif; other site 1278073007858 binding surface 1278073007859 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1278073007860 Phosphotransferase enzyme family; Region: APH; pfam01636 1278073007861 active site 1278073007862 substrate binding site [chemical binding]; other site 1278073007863 ATP binding site [chemical binding]; other site 1278073007864 SnoaL-like domain; Region: SnoaL_3; pfam13474 1278073007865 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1278073007866 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073007867 TPR motif; other site 1278073007868 binding surface 1278073007869 Myxococcus xanthus paralogous domain TIGR02266; Region: gmx_TIGR02266 1278073007870 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 1278073007871 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 1278073007872 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1278073007873 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1278073007874 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1278073007875 2-enoyl thioester reductase (ETR) like proteins, child 1; Region: ETR_like_1; cd08291 1278073007876 NADP binding site [chemical binding]; other site 1278073007877 dimer interface [polypeptide binding]; other site 1278073007878 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1278073007879 putative deacylase active site [active] 1278073007880 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1278073007881 ATP-grasp domain; Region: ATP-grasp; pfam02222 1278073007882 AIR carboxylase; Region: AIRC; pfam00731 1278073007883 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1278073007884 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1278073007885 metal ion-dependent adhesion site (MIDAS); other site 1278073007886 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1278073007887 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1278073007888 putative substrate translocation pore; other site 1278073007889 putative phosphate acyltransferase; Provisional; Region: PRK05331 1278073007890 Uncharacterized conserved protein [Function unknown]; Region: COG4850 1278073007891 poly(A) polymerase; Region: pcnB; TIGR01942 1278073007892 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1278073007893 active site 1278073007894 NTP binding site [chemical binding]; other site 1278073007895 metal binding triad [ion binding]; metal-binding site 1278073007896 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1278073007897 EamA-like transporter family; Region: EamA; cl17759 1278073007898 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1278073007899 EamA-like transporter family; Region: EamA; pfam00892 1278073007900 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1278073007901 active site 1278073007902 DNA polymerase IV; Validated; Region: PRK02406 1278073007903 DNA binding site [nucleotide binding] 1278073007904 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1278073007905 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1278073007906 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1278073007907 motif II; other site 1278073007908 PS-10 peptidase S37; Region: Peptidase_S37; pfam05576 1278073007909 PS-10 peptidase S37; Region: Peptidase_S37; pfam05576 1278073007910 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1278073007911 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1278073007912 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1278073007913 RNA binding surface [nucleotide binding]; other site 1278073007914 Uncharacterized conserved protein [Function unknown]; Region: COG0432 1278073007915 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1278073007916 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1278073007917 active site 1278073007918 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1278073007919 active site 1278073007920 ATP binding site [chemical binding]; other site 1278073007921 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1278073007922 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073007923 substrate binding site [chemical binding]; other site 1278073007924 activation loop (A-loop); other site 1278073007925 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073007926 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073007927 active site 1278073007928 ATP binding site [chemical binding]; other site 1278073007929 substrate binding site [chemical binding]; other site 1278073007930 activation loop (A-loop); other site 1278073007931 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1278073007932 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 1278073007933 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 1278073007934 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 1278073007935 Predicted transcriptional regulator [Transcription]; Region: COG2378 1278073007936 HTH domain; Region: HTH_11; pfam08279 1278073007937 WYL domain; Region: WYL; pfam13280 1278073007938 short chain dehydrogenase; Provisional; Region: PRK08303 1278073007939 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073007940 NAD(P) binding site [chemical binding]; other site 1278073007941 active site 1278073007942 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1278073007943 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1278073007944 catalytic residue [active] 1278073007945 putative FPP diphosphate binding site; other site 1278073007946 putative FPP binding hydrophobic cleft; other site 1278073007947 dimer interface [polypeptide binding]; other site 1278073007948 putative IPP diphosphate binding site; other site 1278073007949 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1278073007950 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1278073007951 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1278073007952 active site 1278073007953 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1278073007954 protein binding site [polypeptide binding]; other site 1278073007955 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1278073007956 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1278073007957 protein binding site [polypeptide binding]; other site 1278073007958 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1278073007959 putative substrate binding region [chemical binding]; other site 1278073007960 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 1278073007961 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1278073007962 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1278073007963 Glycoprotease family; Region: Peptidase_M22; pfam00814 1278073007964 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1278073007965 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1278073007966 PKD domain; Region: PKD; pfam00801 1278073007967 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1278073007968 MoaE interaction surface [polypeptide binding]; other site 1278073007969 MoeB interaction surface [polypeptide binding]; other site 1278073007970 thiocarboxylated glycine; other site 1278073007971 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1278073007972 MoaE homodimer interface [polypeptide binding]; other site 1278073007973 MoaD interaction [polypeptide binding]; other site 1278073007974 active site residues [active] 1278073007975 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1278073007976 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1278073007977 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1278073007978 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1278073007979 nudix motif; other site 1278073007980 acetyl-CoA synthetase; Provisional; Region: PRK00174 1278073007981 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1278073007982 active site 1278073007983 CoA binding site [chemical binding]; other site 1278073007984 acyl-activating enzyme (AAE) consensus motif; other site 1278073007985 AMP binding site [chemical binding]; other site 1278073007986 acetate binding site [chemical binding]; other site 1278073007987 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1278073007988 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1278073007989 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1278073007990 catalytic residue [active] 1278073007991 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1278073007992 catalytic core [active] 1278073007993 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1278073007994 RNA/DNA hybrid binding site [nucleotide binding]; other site 1278073007995 active site 1278073007996 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 1278073007997 B-box zinc finger; Region: zf-B_box; pfam00643 1278073007998 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 1278073007999 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 1278073008000 PDZ domain; Region: PDZ_2; pfam13180 1278073008001 protein binding site [polypeptide binding]; other site 1278073008002 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1278073008003 16S rRNA methyltransferase B; Provisional; Region: PRK14904 1278073008004 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073008005 S-adenosylmethionine binding site [chemical binding]; other site 1278073008006 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1278073008007 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1278073008008 active site 1278073008009 metal binding site [ion binding]; metal-binding site 1278073008010 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 1278073008011 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1278073008012 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1278073008013 TMP-binding site; other site 1278073008014 ATP-binding site [chemical binding]; other site 1278073008015 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 1278073008016 putative active site; other site 1278073008017 putative metal binding residues [ion binding]; other site 1278073008018 signature motif; other site 1278073008019 putative triphosphate binding site [ion binding]; other site 1278073008020 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1278073008021 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073008022 active site 1278073008023 ATP binding site [chemical binding]; other site 1278073008024 substrate binding site [chemical binding]; other site 1278073008025 activation loop (A-loop); other site 1278073008026 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1278073008027 active site residue [active] 1278073008028 molybdopterin biosynthesis protein MoeB; Validated; Region: PRK08762 1278073008029 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1278073008030 active site residue [active] 1278073008031 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1278073008032 ATP binding site [chemical binding]; other site 1278073008033 substrate interface [chemical binding]; other site 1278073008034 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 1278073008035 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1278073008036 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1278073008037 active site 1278073008038 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1278073008039 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 1278073008040 putative active site [active] 1278073008041 catalytic site [active] 1278073008042 putative metal binding site [ion binding]; other site 1278073008043 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1278073008044 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073008045 active site 1278073008046 ATP binding site [chemical binding]; other site 1278073008047 substrate binding site [chemical binding]; other site 1278073008048 activation loop (A-loop); other site 1278073008049 Protein of unknown function DUF45; Region: DUF45; cl00636 1278073008050 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1278073008051 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073008052 S-adenosylmethionine binding site [chemical binding]; other site 1278073008053 quinolinate synthetase; Provisional; Region: PRK09375 1278073008054 PilZ domain; Region: PilZ; pfam07238 1278073008055 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1278073008056 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073008057 S-adenosylmethionine binding site [chemical binding]; other site 1278073008058 V4R domain; Region: V4R; cl15268 1278073008059 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073008060 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073008061 ATP binding site [chemical binding]; other site 1278073008062 Mg2+ binding site [ion binding]; other site 1278073008063 G-X-G motif; other site 1278073008064 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073008065 active site 1278073008066 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073008067 phosphorylation site [posttranslational modification] 1278073008068 intermolecular recognition site; other site 1278073008069 dimerization interface [polypeptide binding]; other site 1278073008070 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073008071 dimer interface [polypeptide binding]; other site 1278073008072 phosphorylation site [posttranslational modification] 1278073008073 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073008074 ATP binding site [chemical binding]; other site 1278073008075 Mg2+ binding site [ion binding]; other site 1278073008076 G-X-G motif; other site 1278073008077 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 1278073008078 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1278073008079 putative substrate translocation pore; other site 1278073008080 POT family; Region: PTR2; cl17359 1278073008081 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1278073008082 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1278073008083 POT family; Region: PTR2; cl17359 1278073008084 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1278073008085 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1278073008086 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1278073008087 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1278073008088 EamA-like transporter family; Region: EamA; pfam00892 1278073008089 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1278073008090 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1278073008091 active site 1278073008092 metal binding site [ion binding]; metal-binding site 1278073008093 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 1278073008094 active site 1278073008095 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1278073008096 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1278073008097 catalytic residues [active] 1278073008098 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 1278073008099 TPR repeat; Region: TPR_11; pfam13414 1278073008100 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1278073008101 TPR motif; other site 1278073008102 binding surface 1278073008103 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1278073008104 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1278073008105 phosphopeptide binding site; other site 1278073008106 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1278073008107 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1278073008108 Coenzyme A binding pocket [chemical binding]; other site 1278073008109 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1278073008110 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1278073008111 nucleotide binding site [chemical binding]; other site 1278073008112 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1278073008113 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 1278073008114 Family description; Region: UvrD_C_2; pfam13538 1278073008115 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1278073008116 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1278073008117 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1278073008118 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073008119 TPR repeat; Region: TPR_11; pfam13414 1278073008120 binding surface 1278073008121 TPR motif; other site 1278073008122 TPR repeat; Region: TPR_11; pfam13414 1278073008123 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073008124 binding surface 1278073008125 TPR motif; other site 1278073008126 TPR repeat; Region: TPR_11; pfam13414 1278073008127 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073008128 binding surface 1278073008129 TPR motif; other site 1278073008130 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1278073008131 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1278073008132 phosphopeptide binding site; other site 1278073008133 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 1278073008134 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 1278073008135 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 1278073008136 putative ligand binding site [chemical binding]; other site 1278073008137 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1278073008138 Competence protein; Region: Competence; pfam03772 1278073008139 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1278073008140 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 1278073008141 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1278073008142 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1278073008143 phosphopeptide binding site; other site 1278073008144 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1278073008145 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073008146 binding surface 1278073008147 TPR motif; other site 1278073008148 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1278073008149 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1278073008150 active site 1278073008151 HIGH motif; other site 1278073008152 nucleotide binding site [chemical binding]; other site 1278073008153 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1278073008154 KMSKS motif; other site 1278073008155 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1278073008156 tRNA binding surface [nucleotide binding]; other site 1278073008157 anticodon binding site; other site 1278073008158 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1278073008159 PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821 1278073008160 PA/protease or protease-like domain interface [polypeptide binding]; other site 1278073008161 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660 1278073008162 Peptidase family M28; Region: Peptidase_M28; pfam04389 1278073008163 metal binding site [ion binding]; metal-binding site 1278073008164 excinuclease ABC subunit B; Provisional; Region: PRK05298 1278073008165 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1278073008166 ATP binding site [chemical binding]; other site 1278073008167 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1278073008168 nucleotide binding region [chemical binding]; other site 1278073008169 ATP-binding site [chemical binding]; other site 1278073008170 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1278073008171 UvrB/uvrC motif; Region: UVR; pfam02151 1278073008172 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1278073008173 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1278073008174 GIY-YIG motif/motif A; other site 1278073008175 active site 1278073008176 catalytic site [active] 1278073008177 putative DNA binding site [nucleotide binding]; other site 1278073008178 metal binding site [ion binding]; metal-binding site 1278073008179 UvrB/uvrC motif; Region: UVR; pfam02151 1278073008180 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1278073008181 Protein of unknown function (DUF507); Region: DUF507; pfam04368 1278073008182 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1278073008183 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073008184 NAD(P) binding site [chemical binding]; other site 1278073008185 active site 1278073008186 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1278073008187 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1278073008188 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1278073008189 putative effector binding pocket; other site 1278073008190 dimerization interface [polypeptide binding]; other site 1278073008191 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 1278073008192 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 1278073008193 Imelysin; Region: Peptidase_M75; pfam09375 1278073008194 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 1278073008195 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 1278073008196 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 1278073008197 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1278073008198 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1278073008199 catalytic residue [active] 1278073008200 Maf-like protein; Region: Maf; pfam02545 1278073008201 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1278073008202 active site 1278073008203 dimer interface [polypeptide binding]; other site 1278073008204 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1278073008205 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1278073008206 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1278073008207 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1278073008208 metal binding site [ion binding]; metal-binding site 1278073008209 active site 1278073008210 I-site; other site 1278073008211 SurA N-terminal domain; Region: SurA_N_3; cl07813 1278073008212 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1278073008213 rod shape-determining protein MreC; Provisional; Region: PRK13922 1278073008214 rod shape-determining protein MreC; Region: MreC; pfam04085 1278073008215 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1278073008216 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1278073008217 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1278073008218 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1278073008219 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1278073008220 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1278073008221 catalytic residues [active] 1278073008222 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1278073008223 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1278073008224 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1278073008225 tRNA; other site 1278073008226 putative tRNA binding site [nucleotide binding]; other site 1278073008227 putative NADP binding site [chemical binding]; other site 1278073008228 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1278073008229 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1278073008230 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 1278073008231 domain interfaces; other site 1278073008232 active site 1278073008233 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1278073008234 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1278073008235 active site 1278073008236 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1278073008237 active site 1278073008238 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1278073008239 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1278073008240 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1278073008241 Walker A motif; other site 1278073008242 ATP binding site [chemical binding]; other site 1278073008243 Walker B motif; other site 1278073008244 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1278073008245 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1278073008246 active site 1278073008247 metal binding site [ion binding]; metal-binding site 1278073008248 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1278073008249 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1278073008250 nudix motif; other site 1278073008251 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1278073008252 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 1278073008253 putative substrate translocation pore; other site 1278073008254 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1278073008255 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1278073008256 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 1278073008257 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1278073008258 tetramer interface [polypeptide binding]; other site 1278073008259 TPP-binding site [chemical binding]; other site 1278073008260 heterodimer interface [polypeptide binding]; other site 1278073008261 phosphorylation loop region [posttranslational modification] 1278073008262 pyruvate dehydrogenase subunit beta; Validated; Region: PRK09212 1278073008263 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1278073008264 alpha subunit interface [polypeptide binding]; other site 1278073008265 TPP binding site [chemical binding]; other site 1278073008266 heterodimer interface [polypeptide binding]; other site 1278073008267 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1278073008268 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1278073008269 E3 interaction surface; other site 1278073008270 lipoyl attachment site [posttranslational modification]; other site 1278073008271 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1278073008272 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1278073008273 E3 interaction surface; other site 1278073008274 lipoyl attachment site [posttranslational modification]; other site 1278073008275 e3 binding domain; Region: E3_binding; pfam02817 1278073008276 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1278073008277 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073008278 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073008279 active site 1278073008280 phosphorylation site [posttranslational modification] 1278073008281 intermolecular recognition site; other site 1278073008282 dimerization interface [polypeptide binding]; other site 1278073008283 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073008284 ATP binding site [chemical binding]; other site 1278073008285 Mg2+ binding site [ion binding]; other site 1278073008286 G-X-G motif; other site 1278073008287 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073008288 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073008289 active site 1278073008290 phosphorylation site [posttranslational modification] 1278073008291 intermolecular recognition site; other site 1278073008292 dimerization interface [polypeptide binding]; other site 1278073008293 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1278073008294 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1278073008295 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1278073008296 active site 1278073008297 KMSKS motif; other site 1278073008298 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1278073008299 active site 1278073008300 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1278073008301 active site 1278073008302 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073008303 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073008304 active site 1278073008305 ATP binding site [chemical binding]; other site 1278073008306 substrate binding site [chemical binding]; other site 1278073008307 activation loop (A-loop); other site 1278073008308 PEGA domain; Region: PEGA; pfam08308 1278073008309 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1278073008310 CheW-like domain; Region: CheW; pfam01584 1278073008311 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1278073008312 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073008313 S-adenosylmethionine binding site [chemical binding]; other site 1278073008314 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073008315 TPR repeat; Region: TPR_11; pfam13414 1278073008316 binding surface 1278073008317 TPR motif; other site 1278073008318 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1278073008319 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1278073008320 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1278073008321 dimerization interface [polypeptide binding]; other site 1278073008322 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1278073008323 dimer interface [polypeptide binding]; other site 1278073008324 putative CheW interface [polypeptide binding]; other site 1278073008325 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1278073008326 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073008327 active site 1278073008328 phosphorylation site [posttranslational modification] 1278073008329 intermolecular recognition site; other site 1278073008330 dimerization interface [polypeptide binding]; other site 1278073008331 CheW-like domain; Region: CheW; pfam01584 1278073008332 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1278073008333 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1278073008334 putative binding surface; other site 1278073008335 active site 1278073008336 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073008337 ATP binding site [chemical binding]; other site 1278073008338 Mg2+ binding site [ion binding]; other site 1278073008339 G-X-G motif; other site 1278073008340 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1278073008341 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073008342 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073008343 active site 1278073008344 phosphorylation site [posttranslational modification] 1278073008345 intermolecular recognition site; other site 1278073008346 dimerization interface [polypeptide binding]; other site 1278073008347 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073008348 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073008349 dimer interface [polypeptide binding]; other site 1278073008350 phosphorylation site [posttranslational modification] 1278073008351 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 1278073008352 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 1278073008353 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1278073008354 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1278073008355 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 1278073008356 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1278073008357 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1278073008358 ligand binding site [chemical binding]; other site 1278073008359 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1278073008360 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073008361 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073008362 dimer interface [polypeptide binding]; other site 1278073008363 phosphorylation site [posttranslational modification] 1278073008364 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073008365 ATP binding site [chemical binding]; other site 1278073008366 G-X-G motif; other site 1278073008367 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073008368 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073008369 active site 1278073008370 phosphorylation site [posttranslational modification] 1278073008371 intermolecular recognition site; other site 1278073008372 dimerization interface [polypeptide binding]; other site 1278073008373 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1278073008374 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 1278073008375 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 1278073008376 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 1278073008377 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1278073008378 G1 box; other site 1278073008379 GTP/Mg2+ binding site [chemical binding]; other site 1278073008380 G2 box; other site 1278073008381 Switch I region; other site 1278073008382 G3 box; other site 1278073008383 Switch II region; other site 1278073008384 G4 box; other site 1278073008385 G5 box; other site 1278073008386 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 1278073008387 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 1278073008388 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1278073008389 putative active site [active] 1278073008390 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1278073008391 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1278073008392 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1278073008393 motif I; other site 1278073008394 active site 1278073008395 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 1278073008396 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1278073008397 substrate binding site [chemical binding]; other site 1278073008398 oxyanion hole (OAH) forming residues; other site 1278073008399 trimer interface [polypeptide binding]; other site 1278073008400 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 1278073008401 Protein of unknown function (DUF523); Region: DUF523; pfam04463 1278073008402 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1278073008403 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1278073008404 active site 1278073008405 substrate binding site [chemical binding]; other site 1278073008406 cosubstrate binding site; other site 1278073008407 catalytic site [active] 1278073008408 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1278073008409 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1278073008410 dimerization interface [polypeptide binding]; other site 1278073008411 putative ATP binding site [chemical binding]; other site 1278073008412 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1278073008413 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 1278073008414 ligand binding site [chemical binding]; other site 1278073008415 flexible hinge region; other site 1278073008416 cAMP phosphodiesterases class-II; Region: PDEase_II; cl17776 1278073008417 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1278073008418 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1278073008419 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1278073008420 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1278073008421 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1278073008422 AMIN domain; Region: AMIN; pfam11741 1278073008423 AMIN domain; Region: AMIN; pfam11741 1278073008424 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 1278073008425 OstA-like protein; Region: OstA; cl00844 1278073008426 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1278073008427 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1278073008428 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1278073008429 non-specific DNA binding site [nucleotide binding]; other site 1278073008430 salt bridge; other site 1278073008431 sequence-specific DNA binding site [nucleotide binding]; other site 1278073008432 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1278073008433 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1278073008434 enoyl-CoA hydratase; Validated; Region: PRK08139 1278073008435 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1278073008436 substrate binding site [chemical binding]; other site 1278073008437 oxyanion hole (OAH) forming residues; other site 1278073008438 trimer interface [polypeptide binding]; other site 1278073008439 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1278073008440 Peptidase family M23; Region: Peptidase_M23; pfam01551 1278073008441 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1278073008442 putative catalytic site [active] 1278073008443 putative metal binding site [ion binding]; other site 1278073008444 putative phosphate binding site [ion binding]; other site 1278073008445 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 1278073008446 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 1278073008447 Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888 1278073008448 CHASE2 domain; Region: CHASE2; cl01732 1278073008449 CHASE2 domain; Region: CHASE2; pfam05226 1278073008450 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 1278073008451 cyclase homology domain; Region: CHD; cd07302 1278073008452 nucleotidyl binding site; other site 1278073008453 metal binding site [ion binding]; metal-binding site 1278073008454 dimer interface [polypeptide binding]; other site 1278073008455 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1278073008456 dimer interface [polypeptide binding]; other site 1278073008457 [2Fe-2S] cluster binding site [ion binding]; other site 1278073008458 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1278073008459 4Fe-4S binding domain; Region: Fer4; pfam00037 1278073008460 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1278073008461 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1278073008462 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1278073008463 catalytic loop [active] 1278073008464 iron binding site [ion binding]; other site 1278073008465 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1278073008466 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1278073008467 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1278073008468 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1278073008469 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 1278073008470 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 1278073008471 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1278073008472 cyclase homology domain; Region: CHD; cd07302 1278073008473 nucleotidyl binding site; other site 1278073008474 metal binding site [ion binding]; metal-binding site 1278073008475 dimer interface [polypeptide binding]; other site 1278073008476 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1278073008477 Sulfatase; Region: Sulfatase; cl17466 1278073008478 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1278073008479 CoenzymeA binding site [chemical binding]; other site 1278073008480 subunit interaction site [polypeptide binding]; other site 1278073008481 PHB binding site; other site 1278073008482 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl17194 1278073008483 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1278073008484 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1278073008485 dimer interface [polypeptide binding]; other site 1278073008486 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1278073008487 putative CheW interface [polypeptide binding]; other site 1278073008488 amphi-Trp domain; Region: amphi-Trp; TIGR04354 1278073008489 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1278073008490 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1278073008491 catalytic residue [active] 1278073008492 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1278073008493 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1278073008494 active site 1278073008495 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1278073008496 Predicted transcriptional regulator [Transcription]; Region: COG1959 1278073008497 Transcriptional regulator; Region: Rrf2; pfam02082 1278073008498 Deoxyhypusine synthase; Region: DS; cl00826 1278073008499 deoxyhypusine synthase; Region: dhys; TIGR00321 1278073008500 OsmC-like protein; Region: OsmC; pfam02566 1278073008501 arginine decarboxylase; Provisional; Region: PRK05354 1278073008502 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1278073008503 active site 1278073008504 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1278073008505 catalytic residues [active] 1278073008506 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1278073008507 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1278073008508 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073008509 Walker A motif; other site 1278073008510 ATP binding site [chemical binding]; other site 1278073008511 Walker B motif; other site 1278073008512 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 1278073008513 Colicin V production protein; Region: Colicin_V; pfam02674 1278073008514 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1278073008515 HSP70 interaction site [polypeptide binding]; other site 1278073008516 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1278073008517 nucleotide binding site [chemical binding]; other site 1278073008518 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1278073008519 putative dimer interface [polypeptide binding]; other site 1278073008520 putative active site [active] 1278073008521 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1278073008522 ATP binding site [chemical binding]; other site 1278073008523 Mg2+ binding site [ion binding]; other site 1278073008524 G-X-G motif; other site 1278073008525 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1278073008526 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073008527 ATP binding site [chemical binding]; other site 1278073008528 Mg2+ binding site [ion binding]; other site 1278073008529 G-X-G motif; other site 1278073008530 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1278073008531 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 1278073008532 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1278073008533 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1278073008534 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1278073008535 ligand binding site [chemical binding]; other site 1278073008536 hypothetical protein; Provisional; Region: PRK12472 1278073008537 DTW domain; Region: DTW; cl01221 1278073008538 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 1278073008539 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 1278073008540 Bacterial protein of unknown function (DUF879); Region: DUF879; cl15462 1278073008541 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 1278073008542 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 1278073008543 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1278073008544 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 1278073008545 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1278073008546 Protein of unknown function (DUF770); Region: DUF770; cl01402 1278073008547 Protein of unknown function (DUF1305); Region: DUF1305; cl01404 1278073008548 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 1278073008549 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1278073008550 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1278073008551 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1278073008552 ligand binding site [chemical binding]; other site 1278073008553 homodimer interface [polypeptide binding]; other site 1278073008554 NAD(P) binding site [chemical binding]; other site 1278073008555 trimer interface B [polypeptide binding]; other site 1278073008556 trimer interface A [polypeptide binding]; other site 1278073008557 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1278073008558 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1278073008559 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1278073008560 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 1278073008561 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 1278073008562 PS-10 peptidase S37; Region: Peptidase_S37; pfam05576 1278073008563 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1278073008564 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 1278073008565 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1278073008566 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1278073008567 active site 1278073008568 Zn binding site [ion binding]; other site 1278073008569 RDD family; Region: RDD; pfam06271 1278073008570 RDD family; Region: RDD; pfam06271 1278073008571 CAAX protease self-immunity; Region: Abi; pfam02517 1278073008572 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1278073008573 hypothetical protein; Provisional; Region: PRK08609 1278073008574 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 1278073008575 active site 1278073008576 primer binding site [nucleotide binding]; other site 1278073008577 NTP binding site [chemical binding]; other site 1278073008578 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1278073008579 active site 1278073008580 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1278073008581 iron-sulfur cluster [ion binding]; other site 1278073008582 [2Fe-2S] cluster binding site [ion binding]; other site 1278073008583 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1278073008584 MPT binding site; other site 1278073008585 trimer interface [polypeptide binding]; other site 1278073008586 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1278073008587 Peptidase family M28; Region: Peptidase_M28; pfam04389 1278073008588 metal binding site [ion binding]; metal-binding site 1278073008589 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 1278073008590 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 1278073008591 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1278073008592 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1278073008593 putative active site [active] 1278073008594 heme pocket [chemical binding]; other site 1278073008595 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073008596 dimer interface [polypeptide binding]; other site 1278073008597 phosphorylation site [posttranslational modification] 1278073008598 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073008599 ATP binding site [chemical binding]; other site 1278073008600 G-X-G motif; other site 1278073008601 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073008602 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073008603 active site 1278073008604 phosphorylation site [posttranslational modification] 1278073008605 intermolecular recognition site; other site 1278073008606 dimerization interface [polypeptide binding]; other site 1278073008607 acetyl esterase; Provisional; Region: PRK10162 1278073008608 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073008609 binding surface 1278073008610 TPR repeat; Region: TPR_11; pfam13414 1278073008611 TPR motif; other site 1278073008612 TPR repeat; Region: TPR_11; pfam13414 1278073008613 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1278073008614 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1278073008615 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073008616 active site 1278073008617 phosphorylation site [posttranslational modification] 1278073008618 intermolecular recognition site; other site 1278073008619 dimerization interface [polypeptide binding]; other site 1278073008620 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1278073008621 DNA binding site [nucleotide binding] 1278073008622 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073008623 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073008624 dimer interface [polypeptide binding]; other site 1278073008625 phosphorylation site [posttranslational modification] 1278073008626 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073008627 ATP binding site [chemical binding]; other site 1278073008628 Mg2+ binding site [ion binding]; other site 1278073008629 G-X-G motif; other site 1278073008630 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1278073008631 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1278073008632 PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818 1278073008633 PA/protease or protease-like domain interface [polypeptide binding]; other site 1278073008634 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 1278073008635 Zn binding site [ion binding]; other site 1278073008636 REJ domain; Region: REJ; pfam02010 1278073008637 HEAT repeats; Region: HEAT_2; pfam13646 1278073008638 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1278073008639 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1278073008640 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 1278073008641 putative active site [active] 1278073008642 NAD synthetase; Reviewed; Region: nadE; PRK00876 1278073008643 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1278073008644 Ligand Binding Site [chemical binding]; other site 1278073008645 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1278073008646 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1278073008647 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1278073008648 acyl-activating enzyme (AAE) consensus motif; other site 1278073008649 AMP binding site [chemical binding]; other site 1278073008650 active site 1278073008651 CoA binding site [chemical binding]; other site 1278073008652 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 1278073008653 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1278073008654 active site 1278073008655 dimer interface [polypeptide binding]; other site 1278073008656 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1278073008657 Ligand Binding Site [chemical binding]; other site 1278073008658 Molecular Tunnel; other site 1278073008659 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1278073008660 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1278073008661 trimer interface [polypeptide binding]; other site 1278073008662 active site 1278073008663 substrate binding site [chemical binding]; other site 1278073008664 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1278073008665 CoA binding site [chemical binding]; other site 1278073008666 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1278073008667 trimer interface [polypeptide binding]; other site 1278073008668 active site 1278073008669 substrate binding site [chemical binding]; other site 1278073008670 CoA binding site [chemical binding]; other site 1278073008671 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 1278073008672 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1278073008673 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1278073008674 FtsX-like permease family; Region: FtsX; pfam02687 1278073008675 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1278073008676 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1278073008677 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1278073008678 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1278073008679 ligand binding site [chemical binding]; other site 1278073008680 flexible hinge region; other site 1278073008681 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 1278073008682 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1278073008683 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1278073008684 DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466 1278073008685 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1278073008686 NRDE protein; Region: NRDE; cl01315 1278073008687 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 1278073008688 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1278073008689 active site 1278073008690 HIGH motif; other site 1278073008691 KMSKS motif; other site 1278073008692 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1278073008693 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1278073008694 putative tRNA-binding site [nucleotide binding]; other site 1278073008695 dimer interface [polypeptide binding]; other site 1278073008696 putative lyase; Provisional; Region: PRK09687 1278073008697 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1278073008698 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1278073008699 active site 1278073008700 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1278073008701 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1278073008702 Zn2+ binding site [ion binding]; other site 1278073008703 Mg2+ binding site [ion binding]; other site 1278073008704 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1278073008705 active site 1278073008706 phosphorylation site [posttranslational modification] 1278073008707 intermolecular recognition site; other site 1278073008708 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1278073008709 generic binding surface II; other site 1278073008710 generic binding surface I; other site 1278073008711 HD domain; Region: HD; pfam01966 1278073008712 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1278073008713 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 1278073008714 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1278073008715 putative RNA binding site [nucleotide binding]; other site 1278073008716 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073008717 S-adenosylmethionine binding site [chemical binding]; other site 1278073008718 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 1278073008719 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1278073008720 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1278073008721 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 1278073008722 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 1278073008723 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1278073008724 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1278073008725 active site 1278073008726 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1278073008727 Interdomain contacts; other site 1278073008728 Cytokine receptor motif; other site 1278073008729 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1278073008730 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1278073008731 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1278073008732 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1278073008733 Phosphoglycerate kinase; Region: PGK; pfam00162 1278073008734 substrate binding site [chemical binding]; other site 1278073008735 hinge regions; other site 1278073008736 ADP binding site [chemical binding]; other site 1278073008737 catalytic site [active] 1278073008738 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1278073008739 triosephosphate isomerase; Provisional; Region: PRK14565 1278073008740 substrate binding site [chemical binding]; other site 1278073008741 dimer interface [polypeptide binding]; other site 1278073008742 catalytic triad [active] 1278073008743 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1278073008744 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1278073008745 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1278073008746 Int/Topo IB signature motif; other site 1278073008747 Helix-turn-helix domain; Region: HTH_17; pfam12728 1278073008748 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 1278073008749 active site 1278073008750 DNA binding site [nucleotide binding] 1278073008751 catalytic site [active] 1278073008752 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1278073008753 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1278073008754 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1278073008755 DNA methylase; Region: N6_N4_Mtase; cl17433 1278073008756 DNA methylase; Region: N6_N4_Mtase; pfam01555 1278073008757 Virulence-associated protein E; Region: VirE; pfam05272 1278073008758 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1278073008759 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073008760 Phosphonate metabolism protein PhnJ; Region: PhnJ; cl01457 1278073008761 Uncharacterized conserved protein [Function unknown]; Region: COG5323 1278073008762 Terminase-like family; Region: Terminase_6; pfam03237 1278073008763 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1278073008764 Phage portal protein; Region: Phage_portal; pfam04860 1278073008765 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1278073008766 cyclase homology domain; Region: CHD; cd07302 1278073008767 nucleotidyl binding site; other site 1278073008768 metal binding site [ion binding]; metal-binding site 1278073008769 dimer interface [polypeptide binding]; other site 1278073008770 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1278073008771 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1278073008772 ligand binding site [chemical binding]; other site 1278073008773 flexible hinge region; other site 1278073008774 Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; cl17861 1278073008775 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 1278073008776 Phage capsid family; Region: Phage_capsid; pfam05065 1278073008777 Phage major tail protein 2; Region: Phage_tail_2; cl11463 1278073008778 Putative phage tail protein; Region: Phage-tail_3; pfam13550 1278073008779 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1278073008780 Interdomain contacts; other site 1278073008781 Cytokine receptor motif; other site 1278073008782 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073008783 active site 1278073008784 ATP binding site [chemical binding]; other site 1278073008785 substrate binding site [chemical binding]; other site 1278073008786 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1278073008787 activation loop (A-loop); other site 1278073008788 activation loop (A-loop); other site 1278073008789 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1278073008790 non-specific DNA binding site [nucleotide binding]; other site 1278073008791 salt bridge; other site 1278073008792 sequence-specific DNA binding site [nucleotide binding]; other site 1278073008793 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1278073008794 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073008795 active site 1278073008796 ATP binding site [chemical binding]; other site 1278073008797 substrate binding site [chemical binding]; other site 1278073008798 activation loop (A-loop); other site 1278073008799 Protein of unknown function (DUF2381); Region: DUF2381; pfam09544 1278073008800 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 1278073008801 NMT1-like family; Region: NMT1_2; pfam13379 1278073008802 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1278073008803 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1278073008804 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1278073008805 dimer interface [polypeptide binding]; other site 1278073008806 conserved gate region; other site 1278073008807 putative PBP binding loops; other site 1278073008808 ABC-ATPase subunit interface; other site 1278073008809 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1278073008810 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1278073008811 Walker A/P-loop; other site 1278073008812 ATP binding site [chemical binding]; other site 1278073008813 Q-loop/lid; other site 1278073008814 ABC transporter signature motif; other site 1278073008815 Walker B; other site 1278073008816 D-loop; other site 1278073008817 H-loop/switch region; other site 1278073008818 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1278073008819 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1278073008820 dimer interface [polypeptide binding]; other site 1278073008821 conserved gate region; other site 1278073008822 putative PBP binding loops; other site 1278073008823 ABC-ATPase subunit interface; other site 1278073008824 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 1278073008825 AIR carboxylase; Region: AIRC; cl00310 1278073008826 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 1278073008827 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1278073008828 dimer interface [polypeptide binding]; other site 1278073008829 active site 1278073008830 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073008831 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 1278073008832 NAD(P) binding site [chemical binding]; other site 1278073008833 active site 1278073008834 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 1278073008835 putative active site 1 [active] 1278073008836 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 1278073008837 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1278073008838 dimer interface [polypeptide binding]; other site 1278073008839 active site 1278073008840 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 1278073008841 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1278073008842 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1278073008843 Predicted exporter [General function prediction only]; Region: COG4258 1278073008844 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1278073008845 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 1278073008846 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1278073008847 active site 1278073008848 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1278073008849 active sites [active] 1278073008850 tetramer interface [polypeptide binding]; other site 1278073008851 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1278073008852 putative acyl-acceptor binding pocket; other site 1278073008853 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1278073008854 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1278073008855 Ligand binding site; other site 1278073008856 Putative Catalytic site; other site 1278073008857 DXD motif; other site 1278073008858 AMP-binding enzyme; Region: AMP-binding; pfam00501 1278073008859 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1278073008860 acyl-activating enzyme (AAE) consensus motif; other site 1278073008861 AMP binding site [chemical binding]; other site 1278073008862 active site 1278073008863 CoA binding site [chemical binding]; other site 1278073008864 FabA/Z, beta-hydroxyacyl-acyl carrier protein (ACP)-dehydratases: One of several distinct enzyme types of the dissociative, type II, fatty acid synthase system (found in bacteria and plants) required to complete successive cycles of fatty acid elongation; Region: FabA_FabZ; cd00493 1278073008865 active site 2 [active] 1278073008866 dimer interface [polypeptide binding]; other site 1278073008867 active site 1 [active] 1278073008868 Predicted membrane protein [Function unknown]; Region: COG4648 1278073008869 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1278073008870 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1278073008871 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1278073008872 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1278073008873 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1278073008874 putative acyl-acceptor binding pocket; other site 1278073008875 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 1278073008876 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1278073008877 Putative zinc-finger; Region: zf-HC2; pfam13490 1278073008878 Protein kinase; unclassified specificity; Region: STYKc; smart00221 1278073008879 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073008880 active site 1278073008881 ATP binding site [chemical binding]; other site 1278073008882 substrate binding site [chemical binding]; other site 1278073008883 activation loop (A-loop); other site 1278073008884 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073008885 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1278073008886 binding surface 1278073008887 TPR motif; other site 1278073008888 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1278073008889 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073008890 binding surface 1278073008891 TPR motif; other site 1278073008892 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1278073008893 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1278073008894 Tetratricopeptide repeat; Region: TPR_10; pfam13374 1278073008895 RNA polymerase sigma-70 factor, Myxococcales family 1; Region: Sig-70_gmx1; TIGR03001 1278073008896 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1278073008897 DNA binding residues [nucleotide binding] 1278073008898 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1278073008899 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 1278073008900 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1278073008901 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1278073008902 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 1278073008903 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1278073008904 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1278073008905 dimerization interface [polypeptide binding]; other site 1278073008906 acetolactate synthase; Reviewed; Region: PRK08322 1278073008907 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1278073008908 PYR/PP interface [polypeptide binding]; other site 1278073008909 dimer interface [polypeptide binding]; other site 1278073008910 TPP binding site [chemical binding]; other site 1278073008911 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1278073008912 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1278073008913 TPP-binding site [chemical binding]; other site 1278073008914 dimer interface [polypeptide binding]; other site 1278073008915 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1278073008916 Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147 1278073008917 NAD(P) binding site [chemical binding]; other site 1278073008918 catalytic residues [active] 1278073008919 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1278073008920 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1278073008921 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 1278073008922 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase; Region: M28_AAP; cd03879 1278073008923 Peptidase family M28; Region: Peptidase_M28; pfam04389 1278073008924 active site 1278073008925 metal binding site [ion binding]; metal-binding site 1278073008926 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1278073008927 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1278073008928 active site 1278073008929 ATP binding site [chemical binding]; other site 1278073008930 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1278073008931 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1278073008932 Amidase; Region: Amidase; pfam01425 1278073008933 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1278073008934 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1278073008935 putative acyl-acceptor binding pocket; other site 1278073008936 active site 1278073008937 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1278073008938 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1278073008939 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1278073008940 ATP binding site [chemical binding]; other site 1278073008941 putative Mg++ binding site [ion binding]; other site 1278073008942 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1278073008943 nucleotide binding region [chemical binding]; other site 1278073008944 ATP-binding site [chemical binding]; other site 1278073008945 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 1278073008946 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 1278073008947 homodimer interface [polypeptide binding]; other site 1278073008948 homotetramer interface [polypeptide binding]; other site 1278073008949 active site pocket [active] 1278073008950 cleavage site 1278073008951 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 1278073008952 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 1278073008953 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 1278073008954 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073008955 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1278073008956 Walker A motif; other site 1278073008957 Walker A/P-loop; other site 1278073008958 ATP binding site [chemical binding]; other site 1278073008959 ATP binding site [chemical binding]; other site 1278073008960 Walker B motif; other site 1278073008961 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 1278073008962 active site 1278073008963 metal binding site [ion binding]; metal-binding site 1278073008964 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 1278073008965 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1278073008966 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1278073008967 Zn binding site [ion binding]; other site 1278073008968 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1278073008969 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1278073008970 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_2; cd07805 1278073008971 N- and C-terminal domain interface [polypeptide binding]; other site 1278073008972 active site 1278073008973 MgATP binding site [chemical binding]; other site 1278073008974 catalytic site [active] 1278073008975 metal binding site [ion binding]; metal-binding site 1278073008976 xylulose binding site [chemical binding]; other site 1278073008977 putative homodimer interface [polypeptide binding]; other site 1278073008978 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 1278073008979 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1278073008980 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1278073008981 catalytic residue [active] 1278073008982 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1278073008983 active site 1278073008984 dimer interface [polypeptide binding]; other site 1278073008985 motif 2; other site 1278073008986 motif 3; other site 1278073008987 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 1278073008988 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1278073008989 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183 1278073008990 putative active site [active] 1278073008991 metal binding site [ion binding]; metal-binding site 1278073008992 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1278073008993 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1278073008994 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 1278073008995 AAA ATPase domain; Region: AAA_16; pfam13191 1278073008996 TPR repeat; Region: TPR_11; pfam13414 1278073008997 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073008998 TPR motif; other site 1278073008999 binding surface 1278073009000 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1278073009001 Peptidase family M23; Region: Peptidase_M23; pfam01551 1278073009002 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1278073009003 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1278073009004 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1278073009005 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1278073009006 motif II; other site 1278073009007 coproporphyrinogen III oxidase; Validated; Region: PRK08208 1278073009008 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1278073009009 FeS/SAM binding site; other site 1278073009010 HemN C-terminal domain; Region: HemN_C; pfam06969 1278073009011 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1278073009012 FeS/SAM binding site; other site 1278073009013 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1278073009014 repeat-companion domain TIGR02996; Region: rpt_mate_G_obs 1278073009015 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 1278073009016 repeat-companion domain TIGR02996; Region: rpt_mate_G_obs 1278073009017 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1278073009018 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1278073009019 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 1278073009020 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073009021 S-adenosylmethionine binding site [chemical binding]; other site 1278073009022 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1278073009023 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073009024 Walker A motif; other site 1278073009025 ATP binding site [chemical binding]; other site 1278073009026 Walker B motif; other site 1278073009027 arginine finger; other site 1278073009028 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073009029 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1278073009030 Walker A motif; other site 1278073009031 ATP binding site [chemical binding]; other site 1278073009032 Walker B motif; other site 1278073009033 arginine finger; other site 1278073009034 Peptidase family M41; Region: Peptidase_M41; pfam01434 1278073009035 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1278073009036 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1278073009037 FeS/SAM binding site; other site 1278073009038 PilZ domain; Region: PilZ; pfam07238 1278073009039 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073009040 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1278073009041 Walker A motif; other site 1278073009042 ATP binding site [chemical binding]; other site 1278073009043 Walker B motif; other site 1278073009044 arginine finger; other site 1278073009045 hypothetical protein; Validated; Region: PRK08223 1278073009046 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 1278073009047 ATP binding site [chemical binding]; other site 1278073009048 substrate interface [chemical binding]; other site 1278073009049 Penicillin amidase; Region: Penicil_amidase; pfam01804 1278073009050 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1278073009051 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1278073009052 active site 1278073009053 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1278073009054 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1278073009055 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1278073009056 Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; cl02268 1278073009057 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1278073009058 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073009059 active site 1278073009060 ATP binding site [chemical binding]; other site 1278073009061 substrate binding site [chemical binding]; other site 1278073009062 activation loop (A-loop); other site 1278073009063 PEGA domain; Region: PEGA; pfam08308 1278073009064 PEGA domain; Region: PEGA; pfam08308 1278073009065 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073009066 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073009067 active site 1278073009068 ATP binding site [chemical binding]; other site 1278073009069 substrate binding site [chemical binding]; other site 1278073009070 activation loop (A-loop); other site 1278073009071 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1278073009072 DNA binding residues [nucleotide binding] 1278073009073 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1278073009074 DNA binding residues [nucleotide binding] 1278073009075 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1278073009076 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1278073009077 purine monophosphate binding site [chemical binding]; other site 1278073009078 dimer interface [polypeptide binding]; other site 1278073009079 putative catalytic residues [active] 1278073009080 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1278073009081 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1278073009082 zinc-ribbon domain; Region: zinc_ribbon_4; pfam13717 1278073009083 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073009084 TPR motif; other site 1278073009085 binding surface 1278073009086 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1278073009087 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1278073009088 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1278073009089 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1278073009090 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1278073009091 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1278073009092 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1278073009093 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1278073009094 O-Antigen ligase; Region: Wzy_C; pfam04932 1278073009095 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1278073009096 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1278073009097 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1278073009098 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 1278073009099 putative ADP-binding pocket [chemical binding]; other site 1278073009100 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 1278073009101 CoA binding domain; Region: CoA_binding; smart00881 1278073009102 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1278073009103 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1278073009104 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1278073009105 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1278073009106 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1278073009107 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 1278073009108 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 1278073009109 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1278073009110 active site 1278073009111 dimer interface [polypeptide binding]; other site 1278073009112 effector binding site; other site 1278073009113 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1278073009114 TSCPD domain; Region: TSCPD; pfam12637 1278073009115 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1278073009116 dimer interface [polypeptide binding]; other site 1278073009117 [2Fe-2S] cluster binding site [ion binding]; other site 1278073009118 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1278073009119 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1278073009120 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1278073009121 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 1278073009122 MerC mercury resistance protein; Region: MerC; pfam03203 1278073009123 Isochorismatase family; Region: Isochorismatase; pfam00857 1278073009124 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1278073009125 catalytic triad [active] 1278073009126 dimer interface [polypeptide binding]; other site 1278073009127 conserved cis-peptide bond; other site 1278073009128 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1278073009129 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1278073009130 ABC-ATPase subunit interface; other site 1278073009131 dimer interface [polypeptide binding]; other site 1278073009132 putative PBP binding regions; other site 1278073009133 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1278073009134 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073009135 Walker A/P-loop; other site 1278073009136 ATP binding site [chemical binding]; other site 1278073009137 Q-loop/lid; other site 1278073009138 ABC transporter signature motif; other site 1278073009139 Walker B; other site 1278073009140 D-loop; other site 1278073009141 H-loop/switch region; other site 1278073009142 Periplasmic binding protein TroA_c. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_c; cd01145 1278073009143 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1278073009144 putative ligand binding site [chemical binding]; other site 1278073009145 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1278073009146 iron-sulfur cluster [ion binding]; other site 1278073009147 [2Fe-2S] cluster binding site [ion binding]; other site 1278073009148 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 1278073009149 active site 1278073009150 FAD binding domain; Region: FAD_binding_4; pfam01565 1278073009151 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1278073009152 HisG, C-terminal domain; Region: HisG_C; cl06867 1278073009153 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1278073009154 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1278073009155 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073009156 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1278073009157 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1278073009158 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1278073009159 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1278073009160 acyl-activating enzyme (AAE) consensus motif; other site 1278073009161 acyl-activating enzyme (AAE) consensus motif; other site 1278073009162 putative AMP binding site [chemical binding]; other site 1278073009163 putative active site [active] 1278073009164 putative CoA binding site [chemical binding]; other site 1278073009165 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1278073009166 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073009167 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073009168 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073009169 active site 1278073009170 phosphorylation site [posttranslational modification] 1278073009171 intermolecular recognition site; other site 1278073009172 dimerization interface [polypeptide binding]; other site 1278073009173 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1278073009174 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 1278073009175 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1278073009176 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1278073009177 MarR family; Region: MarR; pfam01047 1278073009178 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1278073009179 Protein export membrane protein; Region: SecD_SecF; cl14618 1278073009180 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1278073009181 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1278073009182 E3 interaction surface; other site 1278073009183 lipoyl attachment site [posttranslational modification]; other site 1278073009184 HlyD family secretion protein; Region: HlyD_3; pfam13437 1278073009185 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1278073009186 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1278073009187 active site 1278073009188 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1278073009189 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1278073009190 MG2 domain; Region: A2M_N; pfam01835 1278073009191 Alpha-2-macroglobulin family; Region: A2M; pfam00207 1278073009192 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1278073009193 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 1278073009194 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1278073009195 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1278073009196 active site 1278073009197 HIGH motif; other site 1278073009198 dimer interface [polypeptide binding]; other site 1278073009199 KMSKS motif; other site 1278073009200 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1278073009201 RNA binding surface [nucleotide binding]; other site 1278073009202 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1278073009203 putative active site [active] 1278073009204 metal binding site [ion binding]; metal-binding site 1278073009205 homodimer binding site [polypeptide binding]; other site 1278073009206 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1278073009207 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1278073009208 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073009209 binding surface 1278073009210 TPR motif; other site 1278073009211 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1278073009212 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073009213 active site 1278073009214 ATP binding site [chemical binding]; other site 1278073009215 substrate binding site [chemical binding]; other site 1278073009216 activation loop (A-loop); other site 1278073009217 Right handed beta helix region; Region: Beta_helix; pfam13229 1278073009218 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1278073009219 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1278073009220 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1278073009221 catalytic residue [active] 1278073009222 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1278073009223 DHH family; Region: DHH; pfam01368 1278073009224 Fic family protein [Function unknown]; Region: COG3177 1278073009225 Fic/DOC family; Region: Fic; pfam02661 1278073009226 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073009227 Walker A motif; other site 1278073009228 ATP binding site [chemical binding]; other site 1278073009229 Walker B motif; other site 1278073009230 arginine finger; other site 1278073009231 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1278073009232 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1278073009233 homodimer interface [polypeptide binding]; other site 1278073009234 substrate-cofactor binding pocket; other site 1278073009235 catalytic residue [active] 1278073009236 Patatin-like phospholipase; Region: Patatin; pfam01734 1278073009237 active site 1278073009238 nucleophile elbow; other site 1278073009239 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073009240 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1278073009241 Walker A motif; other site 1278073009242 ATP binding site [chemical binding]; other site 1278073009243 Walker B motif; other site 1278073009244 arginine finger; other site 1278073009245 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073009246 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073009247 active site 1278073009248 phosphorylation site [posttranslational modification] 1278073009249 intermolecular recognition site; other site 1278073009250 dimerization interface [polypeptide binding]; other site 1278073009251 chromosome segregation protein; Provisional; Region: PRK02224 1278073009252 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1278073009253 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1278073009254 Rhoptry-associated protein 1 (RAP-1); Region: RAP1; pfam07218 1278073009255 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 1278073009256 Uncharacterized conserved protein [Function unknown]; Region: COG1543 1278073009257 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 1278073009258 active site 1278073009259 substrate binding site [chemical binding]; other site 1278073009260 catalytic site [active] 1278073009261 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 1278073009262 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1278073009263 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1278073009264 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1278073009265 protein binding site [polypeptide binding]; other site 1278073009266 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1278073009267 protein binding site [polypeptide binding]; other site 1278073009268 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1278073009269 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1278073009270 dimerization interface [polypeptide binding]; other site 1278073009271 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1278073009272 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1278073009273 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1278073009274 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1278073009275 metal binding site [ion binding]; metal-binding site 1278073009276 active site 1278073009277 I-site; other site 1278073009278 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1278073009279 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1278073009280 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1278073009281 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1278073009282 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1278073009283 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1278073009284 DNA protecting protein DprA; Region: dprA; TIGR00732 1278073009285 DNA topoisomerase I; Validated; Region: PRK06599 1278073009286 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1278073009287 active site 1278073009288 interdomain interaction site; other site 1278073009289 putative metal-binding site [ion binding]; other site 1278073009290 nucleotide binding site [chemical binding]; other site 1278073009291 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1278073009292 domain I; other site 1278073009293 DNA binding groove [nucleotide binding] 1278073009294 phosphate binding site [ion binding]; other site 1278073009295 domain II; other site 1278073009296 domain III; other site 1278073009297 nucleotide binding site [chemical binding]; other site 1278073009298 catalytic site [active] 1278073009299 domain IV; other site 1278073009300 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1278073009301 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1278073009302 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1278073009303 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1278073009304 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1278073009305 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1278073009306 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1278073009307 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1278073009308 Glucose inhibited division protein A; Region: GIDA; pfam01134 1278073009309 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 1278073009310 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1278073009311 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1278073009312 active site 1278073009313 DNA binding site [nucleotide binding] 1278073009314 Int/Topo IB signature motif; other site 1278073009315 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1278073009316 active site 1278073009317 HslU subunit interaction site [polypeptide binding]; other site 1278073009318 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1278073009319 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073009320 Walker A motif; other site 1278073009321 ATP binding site [chemical binding]; other site 1278073009322 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1278073009323 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1278073009324 acetylornithine aminotransferase; Provisional; Region: PRK02627 1278073009325 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1278073009326 inhibitor-cofactor binding pocket; inhibition site 1278073009327 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1278073009328 catalytic residue [active] 1278073009329 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1278073009330 HSP70 interaction site [polypeptide binding]; other site 1278073009331 TPR repeat; Region: TPR_11; pfam13414 1278073009332 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1278073009333 TPR motif; other site 1278073009334 binding surface 1278073009335 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1278073009336 nucleotide binding site [chemical binding]; other site 1278073009337 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1278073009338 active site 1278073009339 metal binding site [ion binding]; metal-binding site 1278073009340 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1278073009341 active site 1278073009342 catalytic site [active] 1278073009343 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1278073009344 active site 2 [active] 1278073009345 active site 1 [active] 1278073009346 thioester reductase domain; Region: Thioester-redct; TIGR01746 1278073009347 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 1278073009348 putative NAD(P) binding site [chemical binding]; other site 1278073009349 active site 1278073009350 putative substrate binding site [chemical binding]; other site 1278073009351 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1278073009352 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1278073009353 CoA-binding site [chemical binding]; other site 1278073009354 ATP-binding [chemical binding]; other site 1278073009355 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 1278073009356 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1278073009357 G1 box; other site 1278073009358 GTP/Mg2+ binding site [chemical binding]; other site 1278073009359 Switch I region; other site 1278073009360 G2 box; other site 1278073009361 G3 box; other site 1278073009362 Switch II region; other site 1278073009363 G4 box; other site 1278073009364 G5 box; other site 1278073009365 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1278073009366 O-Antigen ligase; Region: Wzy_C; cl04850 1278073009367 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1278073009368 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1278073009369 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1278073009370 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1278073009371 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1278073009372 quinone interaction residues [chemical binding]; other site 1278073009373 active site 1278073009374 catalytic residues [active] 1278073009375 FMN binding site [chemical binding]; other site 1278073009376 substrate binding site [chemical binding]; other site 1278073009377 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1278073009378 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1278073009379 active site 1278073009380 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 1278073009381 Smr domain; Region: Smr; pfam01713 1278073009382 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1278073009383 HSP70 interaction site [polypeptide binding]; other site 1278073009384 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 1278073009385 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1278073009386 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1278073009387 homodimer interface [polypeptide binding]; other site 1278073009388 NADP binding site [chemical binding]; other site 1278073009389 substrate binding site [chemical binding]; other site 1278073009390 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1278073009391 PGAP1-like protein; Region: PGAP1; pfam07819 1278073009392 Protein of unknown function (DUF2378); Region: DUF2378; pfam09536 1278073009393 Bacterial protein of unknown function (DUF937); Region: DUF937; pfam06078 1278073009394 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1278073009395 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1278073009396 ligand binding site [chemical binding]; other site 1278073009397 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1278073009398 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073009399 ATP binding site [chemical binding]; other site 1278073009400 Mg2+ binding site [ion binding]; other site 1278073009401 G-X-G motif; other site 1278073009402 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1278073009403 FAD binding site [chemical binding]; other site 1278073009404 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1278073009405 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1278073009406 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1278073009407 lipoyl attachment site [posttranslational modification]; other site 1278073009408 glycine dehydrogenase; Provisional; Region: PRK05367 1278073009409 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1278073009410 tetramer interface [polypeptide binding]; other site 1278073009411 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1278073009412 catalytic residue [active] 1278073009413 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1278073009414 tetramer interface [polypeptide binding]; other site 1278073009415 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1278073009416 catalytic residue [active] 1278073009417 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1278073009418 Cation efflux family; Region: Cation_efflux; pfam01545 1278073009419 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 1278073009420 Stage II sporulation protein; Region: SpoIID; pfam08486 1278073009421 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1278073009422 Right handed beta helix region; Region: Beta_helix; pfam13229 1278073009423 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1278073009424 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1278073009425 active site 1278073009426 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1278073009427 active site residue [active] 1278073009428 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 1278073009429 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1278073009430 Ferredoxin [Energy production and conversion]; Region: COG1146 1278073009431 4Fe-4S binding domain; Region: Fer4; pfam00037 1278073009432 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 1278073009433 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 1278073009434 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1278073009435 Coenzyme A binding pocket [chemical binding]; other site 1278073009436 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 1278073009437 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1278073009438 ATP binding site [chemical binding]; other site 1278073009439 putative Mg++ binding site [ion binding]; other site 1278073009440 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1278073009441 nucleotide binding region [chemical binding]; other site 1278073009442 Helicase associated domain (HA2); Region: HA2; pfam04408 1278073009443 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1278073009444 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1278073009445 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1278073009446 motif II; other site 1278073009447 HEAT repeats; Region: HEAT_2; pfam13646 1278073009448 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 1278073009449 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1278073009450 metal ion-dependent adhesion site (MIDAS); other site 1278073009451 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 1278073009452 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1278073009453 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1278073009454 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1278073009455 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1278073009456 elongation factor Tu; Reviewed; Region: PRK00049 1278073009457 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1278073009458 G1 box; other site 1278073009459 GEF interaction site [polypeptide binding]; other site 1278073009460 GTP/Mg2+ binding site [chemical binding]; other site 1278073009461 Switch I region; other site 1278073009462 G2 box; other site 1278073009463 G3 box; other site 1278073009464 Switch II region; other site 1278073009465 G4 box; other site 1278073009466 G5 box; other site 1278073009467 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1278073009468 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1278073009469 Antibiotic Binding Site [chemical binding]; other site 1278073009470 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1278073009471 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 1278073009472 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1278073009473 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1278073009474 putative homodimer interface [polypeptide binding]; other site 1278073009475 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1278073009476 heterodimer interface [polypeptide binding]; other site 1278073009477 homodimer interface [polypeptide binding]; other site 1278073009478 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1278073009479 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1278073009480 23S rRNA interface [nucleotide binding]; other site 1278073009481 L7/L12 interface [polypeptide binding]; other site 1278073009482 putative thiostrepton binding site; other site 1278073009483 L25 interface [polypeptide binding]; other site 1278073009484 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1278073009485 mRNA/rRNA interface [nucleotide binding]; other site 1278073009486 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1278073009487 23S rRNA interface [nucleotide binding]; other site 1278073009488 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1278073009489 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1278073009490 core dimer interface [polypeptide binding]; other site 1278073009491 peripheral dimer interface [polypeptide binding]; other site 1278073009492 L10 interface [polypeptide binding]; other site 1278073009493 L11 interface [polypeptide binding]; other site 1278073009494 putative EF-Tu interaction site [polypeptide binding]; other site 1278073009495 putative EF-G interaction site [polypeptide binding]; other site 1278073009496 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1278073009497 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1278073009498 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1278073009499 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1278073009500 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1278073009501 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1278073009502 RPB3 interaction site [polypeptide binding]; other site 1278073009503 RPB1 interaction site [polypeptide binding]; other site 1278073009504 RPB11 interaction site [polypeptide binding]; other site 1278073009505 RPB10 interaction site [polypeptide binding]; other site 1278073009506 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1278073009507 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1278073009508 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1278073009509 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1278073009510 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1278073009511 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1278073009512 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1278073009513 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1278073009514 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1278073009515 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1278073009516 DNA binding site [nucleotide binding] 1278073009517 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1278073009518 seryl-tRNA synthetase; Provisional; Region: PRK05431 1278073009519 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 1278073009520 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1278073009521 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1278073009522 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1278073009523 catalytic residue [active] 1278073009524 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 1278073009525 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073009526 binding surface 1278073009527 TPR motif; other site 1278073009528 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073009529 binding surface 1278073009530 TPR motif; other site 1278073009531 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073009532 binding surface 1278073009533 TPR motif; other site 1278073009534 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1278073009535 non-specific DNA binding site [nucleotide binding]; other site 1278073009536 salt bridge; other site 1278073009537 sequence-specific DNA binding site [nucleotide binding]; other site 1278073009538 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1278073009539 Recombination protein O N terminal; Region: RecO_N; pfam11967 1278073009540 Recombination protein O C terminal; Region: RecO_C; pfam02565 1278073009541 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1278073009542 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1278073009543 putative substrate binding site [chemical binding]; other site 1278073009544 putative ATP binding site [chemical binding]; other site 1278073009545 oligopeptide transporter, OPT superfamily; Region: OPT_sfam; TIGR00728 1278073009546 OPT oligopeptide transporter protein; Region: OPT; pfam03169 1278073009547 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073009548 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073009549 active site 1278073009550 ATP binding site [chemical binding]; other site 1278073009551 substrate binding site [chemical binding]; other site 1278073009552 activation loop (A-loop); other site 1278073009553 AAA ATPase domain; Region: AAA_16; pfam13191 1278073009554 AAA domain; Region: AAA_22; pfam13401 1278073009555 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1278073009556 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073009557 active site 1278073009558 ATP binding site [chemical binding]; other site 1278073009559 substrate binding site [chemical binding]; other site 1278073009560 Protein kinase domain; Region: Pkinase; pfam00069 1278073009561 activation loop (A-loop); other site 1278073009562 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1278073009563 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1278073009564 phosphopeptide binding site; other site 1278073009565 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1278073009566 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073009567 Walker A motif; other site 1278073009568 ATP binding site [chemical binding]; other site 1278073009569 Walker B motif; other site 1278073009570 arginine finger; other site 1278073009571 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1278073009572 Putative cyclase; Region: Cyclase; pfam04199 1278073009573 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1278073009574 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1278073009575 dimerization interface [polypeptide binding]; other site 1278073009576 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 1278073009577 Glutaminase; Region: Glutaminase; cl00907 1278073009578 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1278073009579 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1278073009580 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1278073009581 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1278073009582 catalytic residue [active] 1278073009583 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1278073009584 Protein of unknown function (DUF3969); Region: DUF3969; pfam13108 1278073009585 PAS domain S-box; Region: sensory_box; TIGR00229 1278073009586 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1278073009587 putative active site [active] 1278073009588 heme pocket [chemical binding]; other site 1278073009589 PAS domain S-box; Region: sensory_box; TIGR00229 1278073009590 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1278073009591 putative active site [active] 1278073009592 heme pocket [chemical binding]; other site 1278073009593 GAF domain; Region: GAF; pfam01590 1278073009594 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073009595 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073009596 dimer interface [polypeptide binding]; other site 1278073009597 phosphorylation site [posttranslational modification] 1278073009598 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073009599 ATP binding site [chemical binding]; other site 1278073009600 Mg2+ binding site [ion binding]; other site 1278073009601 G-X-G motif; other site 1278073009602 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1278073009603 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1278073009604 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1278073009605 HlyD family secretion protein; Region: HlyD_3; pfam13437 1278073009606 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1278073009607 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1278073009608 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1278073009609 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1278073009610 ligand binding site [chemical binding]; other site 1278073009611 flexible hinge region; other site 1278073009612 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073009613 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073009614 active site 1278073009615 ATP binding site [chemical binding]; other site 1278073009616 substrate binding site [chemical binding]; other site 1278073009617 activation loop (A-loop); other site 1278073009618 PEGA domain; Region: PEGA; pfam08308 1278073009619 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1278073009620 dimer interface [polypeptide binding]; other site 1278073009621 motif 1; other site 1278073009622 active site 1278073009623 motif 2; other site 1278073009624 motif 3; other site 1278073009625 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1278073009626 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1278073009627 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1278073009628 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1278073009629 phosphopeptide binding site; other site 1278073009630 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1278073009631 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 1278073009632 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1278073009633 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1278073009634 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1278073009635 phosphopeptide binding site; other site 1278073009636 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1278073009637 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1278073009638 ATP binding site [chemical binding]; other site 1278073009639 Walker A motif; other site 1278073009640 hexamer interface [polypeptide binding]; other site 1278073009641 Walker B motif; other site 1278073009642 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1278073009643 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1278073009644 phosphopeptide binding site; other site 1278073009645 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1278073009646 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1278073009647 phosphopeptide binding site; other site 1278073009648 DNA polymerase I; Provisional; Region: PRK05755 1278073009649 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1278073009650 active site 1278073009651 metal binding site 1 [ion binding]; metal-binding site 1278073009652 putative 5' ssDNA interaction site; other site 1278073009653 metal binding site 3; metal-binding site 1278073009654 metal binding site 2 [ion binding]; metal-binding site 1278073009655 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1278073009656 putative DNA binding site [nucleotide binding]; other site 1278073009657 putative metal binding site [ion binding]; other site 1278073009658 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1278073009659 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1278073009660 active site 1278073009661 DNA binding site [nucleotide binding] 1278073009662 catalytic site [active] 1278073009663 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1278073009664 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 1278073009665 DivIVA protein; Region: DivIVA; pfam05103 1278073009666 DivIVA domain; Region: DivI1A_domain; TIGR03544 1278073009667 HEAT repeats; Region: HEAT_2; pfam13646 1278073009668 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1278073009669 HSP70 interaction site [polypeptide binding]; other site 1278073009670 Integral membrane protein DUF95; Region: DUF95; pfam01944 1278073009671 RDD family; Region: RDD; pfam06271 1278073009672 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073009673 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1278073009674 active site 1278073009675 phosphorylation site [posttranslational modification] 1278073009676 intermolecular recognition site; other site 1278073009677 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1278073009678 DNA binding residues [nucleotide binding] 1278073009679 dimerization interface [polypeptide binding]; other site 1278073009680 MbtH-like protein; Region: MbtH; cl01279 1278073009681 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073009682 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1278073009683 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1278073009684 acyl-activating enzyme (AAE) consensus motif; other site 1278073009685 AMP binding site [chemical binding]; other site 1278073009686 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073009687 Condensation domain; Region: Condensation; pfam00668 1278073009688 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073009689 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073009690 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073009691 acyl-activating enzyme (AAE) consensus motif; other site 1278073009692 AMP binding site [chemical binding]; other site 1278073009693 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073009694 Condensation domain; Region: Condensation; pfam00668 1278073009695 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073009696 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073009697 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073009698 acyl-activating enzyme (AAE) consensus motif; other site 1278073009699 AMP binding site [chemical binding]; other site 1278073009700 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073009701 Condensation domain; Region: Condensation; pfam00668 1278073009702 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073009703 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073009704 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073009705 acyl-activating enzyme (AAE) consensus motif; other site 1278073009706 AMP binding site [chemical binding]; other site 1278073009707 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073009708 Condensation domain; Region: Condensation; pfam00668 1278073009709 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073009710 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073009711 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073009712 acyl-activating enzyme (AAE) consensus motif; other site 1278073009713 AMP binding site [chemical binding]; other site 1278073009714 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073009715 Condensation domain; Region: Condensation; pfam00668 1278073009716 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073009717 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073009718 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073009719 acyl-activating enzyme (AAE) consensus motif; other site 1278073009720 AMP binding site [chemical binding]; other site 1278073009721 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073009722 Condensation domain; Region: Condensation; pfam00668 1278073009723 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073009724 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073009725 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073009726 acyl-activating enzyme (AAE) consensus motif; other site 1278073009727 AMP binding site [chemical binding]; other site 1278073009728 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073009729 Condensation domain; Region: Condensation; pfam00668 1278073009730 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073009731 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073009732 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073009733 acyl-activating enzyme (AAE) consensus motif; other site 1278073009734 AMP binding site [chemical binding]; other site 1278073009735 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073009736 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1278073009737 CoA binding site [chemical binding]; other site 1278073009738 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073009739 Condensation domain; Region: Condensation; pfam00668 1278073009740 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073009741 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073009742 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073009743 acyl-activating enzyme (AAE) consensus motif; other site 1278073009744 AMP binding site [chemical binding]; other site 1278073009745 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073009746 Condensation domain; Region: Condensation; pfam00668 1278073009747 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073009748 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1278073009749 Condensation domain; Region: Condensation; pfam00668 1278073009750 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073009751 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073009752 acyl-activating enzyme (AAE) consensus motif; other site 1278073009753 AMP binding site [chemical binding]; other site 1278073009754 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073009755 Condensation domain; Region: Condensation; pfam00668 1278073009756 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073009757 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073009758 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1278073009759 acyl-activating enzyme (AAE) consensus motif; other site 1278073009760 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1278073009761 CoA binding site [chemical binding]; other site 1278073009762 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073009763 Condensation domain; Region: Condensation; pfam00668 1278073009764 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073009765 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073009766 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1278073009767 acyl-activating enzyme (AAE) consensus motif; other site 1278073009768 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073009769 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1278073009770 active site 1278073009771 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1278073009772 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1278073009773 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1278073009774 putative NADP binding site [chemical binding]; other site 1278073009775 active site 1278073009776 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073009777 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 1278073009778 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1278073009779 homodimer interface [polypeptide binding]; other site 1278073009780 active site 1278073009781 TDP-binding site; other site 1278073009782 acceptor substrate-binding pocket; other site 1278073009783 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1278073009784 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073009785 active site 1278073009786 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1278073009787 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073009788 NAD(P) binding site [chemical binding]; other site 1278073009789 KR domain; Region: KR; pfam08659 1278073009790 active site 1278073009791 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073009792 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1278073009793 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073009794 active site 1278073009795 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1278073009796 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1278073009797 putative NADP binding site [chemical binding]; other site 1278073009798 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1278073009799 active site 1278073009800 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073009801 acyl-CoA synthetase; Validated; Region: PRK05850 1278073009802 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1278073009803 acyl-activating enzyme (AAE) consensus motif; other site 1278073009804 active site 1278073009805 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1278073009806 Condensation domain; Region: Condensation; pfam00668 1278073009807 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073009808 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073009809 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1278073009810 acyl-activating enzyme (AAE) consensus motif; other site 1278073009811 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 1278073009812 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1278073009813 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1278073009814 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073009815 AMP binding site [chemical binding]; other site 1278073009816 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073009817 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1278073009818 Cytochrome P450; Region: p450; cl12078 1278073009819 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 1278073009820 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1278073009821 dimer interface [polypeptide binding]; other site 1278073009822 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1278073009823 active site 1278073009824 Fe binding site [ion binding]; other site 1278073009825 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 1278073009826 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1278073009827 Walker A/P-loop; other site 1278073009828 ATP binding site [chemical binding]; other site 1278073009829 Q-loop/lid; other site 1278073009830 ABC transporter signature motif; other site 1278073009831 Walker B; other site 1278073009832 D-loop; other site 1278073009833 H-loop/switch region; other site 1278073009834 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 1278073009835 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1278073009836 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1278073009837 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1278073009838 TIR domain; Region: TIR_2; cl17458 1278073009839 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1278073009840 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820 1278073009841 dimer interface [polypeptide binding]; other site 1278073009842 active site 1278073009843 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1278073009844 substrate binding site [chemical binding]; other site 1278073009845 catalytic residue [active] 1278073009846 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1278073009847 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1278073009848 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1278073009849 Bacterial SH3 domain; Region: SH3_3; cl17532 1278073009850 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1278073009851 Sulfatase; Region: Sulfatase; cl17466 1278073009852 Sulfatase; Region: Sulfatase; cl17466 1278073009853 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1278073009854 Putative exonuclease, RdgC; Region: RdgC; cl01122 1278073009855 Cupin-like domain; Region: Cupin_8; pfam13621 1278073009856 Cupin-like domain; Region: Cupin_8; pfam13621 1278073009857 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073009858 binding surface 1278073009859 TPR motif; other site 1278073009860 TPR repeat; Region: TPR_11; pfam13414 1278073009861 CHAT domain; Region: CHAT; cl17868 1278073009862 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1278073009863 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1278073009864 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1278073009865 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1278073009866 active site 1278073009867 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1278073009868 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1278073009869 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1278073009870 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1278073009871 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1278073009872 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1278073009873 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1278073009874 putative catalytic site [active] 1278073009875 putative metal binding site [ion binding]; other site 1278073009876 putative phosphate binding site [ion binding]; other site 1278073009877 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1278073009878 exosortase A system-associated hydrolase 2; Region: hydr2_PEP; TIGR03101 1278073009879 exosortase A system-associated hydrolase 1; Region: hydr1_PEP; TIGR03100 1278073009880 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 1278073009881 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1278073009882 catalytic loop [active] 1278073009883 iron binding site [ion binding]; other site 1278073009884 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1278073009885 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1278073009886 Xanthine dehydrogenase, molybdopterin-binding subunit B [Nucleotide transport and metabolism]; Region: XdhB; COG4631 1278073009887 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1278073009888 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1278073009889 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1278073009890 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 1278073009891 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1278073009892 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1278073009893 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1278073009894 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_7; cd08476 1278073009895 putative effector binding pocket; other site 1278073009896 putative dimerization interface [polypeptide binding]; other site 1278073009897 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1278073009898 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1278073009899 putative substrate translocation pore; other site 1278073009900 Predicted membrane protein [Function unknown]; Region: COG2311 1278073009901 Protein of unknown function (DUF418); Region: DUF418; cl12135 1278073009902 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1278073009903 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1278073009904 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1278073009905 minor groove reading motif; other site 1278073009906 helix-hairpin-helix signature motif; other site 1278073009907 substrate binding pocket [chemical binding]; other site 1278073009908 active site 1278073009909 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1278073009910 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1278073009911 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1278073009912 ligand binding site [chemical binding]; other site 1278073009913 flexible hinge region; other site 1278073009914 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 1278073009915 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1278073009916 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1278073009917 substrate binding site [chemical binding]; other site 1278073009918 oxyanion hole (OAH) forming residues; other site 1278073009919 trimer interface [polypeptide binding]; other site 1278073009920 Helix-turn-helix domain; Region: HTH_28; pfam13518 1278073009921 putative transposase OrfB; Reviewed; Region: PHA02517 1278073009922 HTH-like domain; Region: HTH_21; pfam13276 1278073009923 Integrase core domain; Region: rve; pfam00665 1278073009924 Integrase core domain; Region: rve_3; pfam13683 1278073009925 TIR domain; Region: TIR_2; pfam13676 1278073009926 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1278073009927 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1278073009928 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1278073009929 G3 box; other site 1278073009930 Switch II region; other site 1278073009931 GTP/Mg2+ binding site [chemical binding]; other site 1278073009932 G4 box; other site 1278073009933 G5 box; other site 1278073009934 cyclase homology domain; Region: CHD; cd07302 1278073009935 nucleotidyl binding site; other site 1278073009936 metal binding site [ion binding]; metal-binding site 1278073009937 dimer interface [polypeptide binding]; other site 1278073009938 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1278073009939 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1278073009940 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1278073009941 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1278073009942 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1278073009943 DHHC palmitoyltransferase; Region: zf-DHHC; pfam01529 1278073009944 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 1278073009945 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1278073009946 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1278073009947 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1278073009948 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1278073009949 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1278073009950 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 1278073009951 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1278073009952 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1278073009953 active site 1278073009954 Zn binding site [ion binding]; other site 1278073009955 fumarate hydratase; Provisional; Region: PRK15389 1278073009956 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 1278073009957 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1278073009958 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 1278073009959 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1278073009960 ligand binding site [chemical binding]; other site 1278073009961 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 1278073009962 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1278073009963 amino acid transporter; Region: 2A0306; TIGR00909 1278073009964 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1278073009965 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1278073009966 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1278073009967 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1278073009968 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1278073009969 dimerization interface [polypeptide binding]; other site 1278073009970 light-dependent protochlorophyllide reductase; Region: LPOR; TIGR01289 1278073009971 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073009972 NAD(P) binding site [chemical binding]; other site 1278073009973 active site 1278073009974 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1278073009975 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073009976 binding surface 1278073009977 TPR repeat; Region: TPR_11; pfam13414 1278073009978 TPR motif; other site 1278073009979 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1278073009980 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1278073009981 substrate binding site [chemical binding]; other site 1278073009982 oxyanion hole (OAH) forming residues; other site 1278073009983 trimer interface [polypeptide binding]; other site 1278073009984 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1278073009985 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1278073009986 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1278073009987 dimer interface [polypeptide binding]; other site 1278073009988 putative CheW interface [polypeptide binding]; other site 1278073009989 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1278073009990 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073009991 active site 1278073009992 ATP binding site [chemical binding]; other site 1278073009993 substrate binding site [chemical binding]; other site 1278073009994 activation loop (A-loop); other site 1278073009995 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1278073009996 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1278073009997 putative NAD(P) binding site [chemical binding]; other site 1278073009998 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 1278073009999 Endonuclease I; Region: Endonuclease_1; cl01003 1278073010000 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073010001 NAD(P) binding site [chemical binding]; other site 1278073010002 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1278073010003 active site 1278073010004 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 1278073010005 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1278073010006 dimer interface [polypeptide binding]; other site 1278073010007 active site 1278073010008 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1278073010009 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1278073010010 NAD(P) binding site [chemical binding]; other site 1278073010011 Coenzyme A transferase; Region: CoA_trans; cl17247 1278073010012 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1278073010013 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1278073010014 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1278073010015 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1278073010016 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1278073010017 substrate binding site [chemical binding]; other site 1278073010018 ATP binding site [chemical binding]; other site 1278073010019 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073010020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073010021 active site 1278073010022 phosphorylation site [posttranslational modification] 1278073010023 intermolecular recognition site; other site 1278073010024 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1278073010025 GAF domain; Region: GAF; pfam01590 1278073010026 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1278073010027 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1278073010028 metal binding site [ion binding]; metal-binding site 1278073010029 active site 1278073010030 I-site; other site 1278073010031 CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080 1278073010032 FecR protein; Region: FecR; pfam04773 1278073010033 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 1278073010034 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1278073010035 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1278073010036 ligand binding site [chemical binding]; other site 1278073010037 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073010038 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073010039 active site 1278073010040 phosphorylation site [posttranslational modification] 1278073010041 intermolecular recognition site; other site 1278073010042 dimerization interface [polypeptide binding]; other site 1278073010043 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1278073010044 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073010045 active site 1278073010046 phosphorylation site [posttranslational modification] 1278073010047 intermolecular recognition site; other site 1278073010048 dimerization interface [polypeptide binding]; other site 1278073010049 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073010050 Walker A motif; other site 1278073010051 ATP binding site [chemical binding]; other site 1278073010052 Walker B motif; other site 1278073010053 arginine finger; other site 1278073010054 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1278073010055 PAS fold; Region: PAS_4; pfam08448 1278073010056 PAS fold; Region: PAS_3; pfam08447 1278073010057 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1278073010058 heme pocket [chemical binding]; other site 1278073010059 putative active site [active] 1278073010060 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1278073010061 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073010062 phosphorylation site [posttranslational modification] 1278073010063 dimer interface [polypeptide binding]; other site 1278073010064 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073010065 ATP binding site [chemical binding]; other site 1278073010066 Mg2+ binding site [ion binding]; other site 1278073010067 G-X-G motif; other site 1278073010068 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1278073010069 active site 1278073010070 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 1278073010071 putative hydrophobic ligand binding site [chemical binding]; other site 1278073010072 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1278073010073 heme-binding site [chemical binding]; other site 1278073010074 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073010075 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073010076 dimer interface [polypeptide binding]; other site 1278073010077 phosphorylation site [posttranslational modification] 1278073010078 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073010079 ATP binding site [chemical binding]; other site 1278073010080 Mg2+ binding site [ion binding]; other site 1278073010081 G-X-G motif; other site 1278073010082 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073010083 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073010084 active site 1278073010085 phosphorylation site [posttranslational modification] 1278073010086 intermolecular recognition site; other site 1278073010087 dimerization interface [polypeptide binding]; other site 1278073010088 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073010089 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073010090 active site 1278073010091 phosphorylation site [posttranslational modification] 1278073010092 intermolecular recognition site; other site 1278073010093 dimerization interface [polypeptide binding]; other site 1278073010094 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073010095 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073010096 active site 1278073010097 phosphorylation site [posttranslational modification] 1278073010098 intermolecular recognition site; other site 1278073010099 dimerization interface [polypeptide binding]; other site 1278073010100 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073010101 dimer interface [polypeptide binding]; other site 1278073010102 phosphorylation site [posttranslational modification] 1278073010103 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073010104 ATP binding site [chemical binding]; other site 1278073010105 Mg2+ binding site [ion binding]; other site 1278073010106 G-X-G motif; other site 1278073010107 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 1278073010108 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1278073010109 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1278073010110 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1278073010111 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073010112 active site 1278073010113 phosphorylation site [posttranslational modification] 1278073010114 intermolecular recognition site; other site 1278073010115 dimerization interface [polypeptide binding]; other site 1278073010116 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073010117 Walker A motif; other site 1278073010118 ATP binding site [chemical binding]; other site 1278073010119 Walker B motif; other site 1278073010120 arginine finger; other site 1278073010121 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1278073010122 OsmC-like protein; Region: OsmC; cl00767 1278073010123 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1278073010124 FOG: CBS domain [General function prediction only]; Region: COG0517 1278073010125 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1278073010126 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1278073010127 ThiC-associated domain; Region: ThiC-associated; pfam13667 1278073010128 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1278073010129 Tic20-like protein; Region: Tic20; pfam09685 1278073010130 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 1278073010131 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1278073010132 FeS/SAM binding site; other site 1278073010133 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1278073010134 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073010135 active site 1278073010136 phosphorylation site [posttranslational modification] 1278073010137 intermolecular recognition site; other site 1278073010138 dimerization interface [polypeptide binding]; other site 1278073010139 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1278073010140 Zn2+ binding site [ion binding]; other site 1278073010141 Mg2+ binding site [ion binding]; other site 1278073010142 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1278073010143 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1278073010144 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1278073010145 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1278073010146 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1278073010147 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1278073010148 histidinol dehydrogenase; Region: hisD; TIGR00069 1278073010149 NAD binding site [chemical binding]; other site 1278073010150 dimerization interface [polypeptide binding]; other site 1278073010151 product binding site; other site 1278073010152 substrate binding site [chemical binding]; other site 1278073010153 zinc binding site [ion binding]; other site 1278073010154 catalytic residues [active] 1278073010155 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 1278073010156 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1278073010157 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1278073010158 homodimer interface [polypeptide binding]; other site 1278073010159 catalytic residue [active] 1278073010160 Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118 1278073010161 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1278073010162 conserved cys residue [active] 1278073010163 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1278073010164 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1278073010165 catalytic residues [active] 1278073010166 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cl00341 1278073010167 4-fold oligomerization interface [polypeptide binding]; other site 1278073010168 putative active site pocket [active] 1278073010169 metal binding residues [ion binding]; metal-binding site 1278073010170 3-fold/trimer interface [polypeptide binding]; other site 1278073010171 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1278073010172 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1278073010173 substrate binding site [chemical binding]; other site 1278073010174 glutamase interaction surface [polypeptide binding]; other site 1278073010175 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1278073010176 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 1278073010177 active site 1278073010178 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1278073010179 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1278073010180 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1278073010181 metal binding site [ion binding]; metal-binding site 1278073010182 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1278073010183 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1278073010184 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1278073010185 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1278073010186 lipoyl synthase; Provisional; Region: PRK05481 1278073010187 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1278073010188 FeS/SAM binding site; other site 1278073010189 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1278073010190 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1278073010191 E3 interaction surface; other site 1278073010192 lipoyl attachment site [posttranslational modification]; other site 1278073010193 e3 binding domain; Region: E3_binding; pfam02817 1278073010194 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1278073010195 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 1278073010196 AAA ATPase domain; Region: AAA_16; pfam13191 1278073010197 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1278073010198 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 1278073010199 nudix motif; other site 1278073010200 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1278073010201 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1278073010202 dimerization interface [polypeptide binding]; other site 1278073010203 active site 1278073010204 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1278073010205 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1278073010206 dimer interface [polypeptide binding]; other site 1278073010207 putative functional site; other site 1278073010208 putative MPT binding site; other site 1278073010209 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 1278073010210 ribonuclease R; Region: RNase_R; TIGR02063 1278073010211 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1278073010212 RNB domain; Region: RNB; pfam00773 1278073010213 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1278073010214 RNA binding site [nucleotide binding]; other site 1278073010215 Protein of unknown function (DUF3185); Region: DUF3185; pfam11381 1278073010216 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 1278073010217 amphipathic channel; other site 1278073010218 Asn-Pro-Ala signature motifs; other site 1278073010219 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 1278073010220 S-formylglutathione hydrolase; Region: PLN02442 1278073010221 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1278073010222 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1278073010223 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1278073010224 substrate binding site [chemical binding]; other site 1278073010225 catalytic Zn binding site [ion binding]; other site 1278073010226 NAD binding site [chemical binding]; other site 1278073010227 structural Zn binding site [ion binding]; other site 1278073010228 dimer interface [polypeptide binding]; other site 1278073010229 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073010230 binding surface 1278073010231 TPR motif; other site 1278073010232 TPR repeat; Region: TPR_11; pfam13414 1278073010233 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073010234 binding surface 1278073010235 TPR motif; other site 1278073010236 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 1278073010237 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1278073010238 putative active site [active] 1278073010239 putative metal binding site [ion binding]; other site 1278073010240 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1278073010241 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1278073010242 putative active site [active] 1278073010243 putative metal binding site [ion binding]; other site 1278073010244 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073010245 NAD(P) binding site [chemical binding]; other site 1278073010246 active site 1278073010247 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1278073010248 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1278073010249 FtsX-like permease family; Region: FtsX; pfam02687 1278073010250 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1278073010251 HlyD family secretion protein; Region: HlyD_3; pfam13437 1278073010252 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1278073010253 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1278073010254 Walker A/P-loop; other site 1278073010255 ATP binding site [chemical binding]; other site 1278073010256 Q-loop/lid; other site 1278073010257 ABC transporter signature motif; other site 1278073010258 Walker B; other site 1278073010259 D-loop; other site 1278073010260 H-loop/switch region; other site 1278073010261 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1278073010262 sensor protein ZraS; Provisional; Region: PRK10364 1278073010263 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073010264 dimer interface [polypeptide binding]; other site 1278073010265 phosphorylation site [posttranslational modification] 1278073010266 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073010267 ATP binding site [chemical binding]; other site 1278073010268 Mg2+ binding site [ion binding]; other site 1278073010269 G-X-G motif; other site 1278073010270 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1278073010271 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073010272 active site 1278073010273 phosphorylation site [posttranslational modification] 1278073010274 intermolecular recognition site; other site 1278073010275 dimerization interface [polypeptide binding]; other site 1278073010276 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073010277 Walker A motif; other site 1278073010278 ATP binding site [chemical binding]; other site 1278073010279 Walker B motif; other site 1278073010280 arginine finger; other site 1278073010281 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1278073010282 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073010283 binding surface 1278073010284 TPR motif; other site 1278073010285 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1278073010286 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1278073010287 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1278073010288 active site 1278073010289 Zn binding site [ion binding]; other site 1278073010290 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1278073010291 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1278073010292 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 1278073010293 active site 1278073010294 catalytic site [active] 1278073010295 putative metal binding site [ion binding]; other site 1278073010296 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 1278073010297 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1278073010298 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1278073010299 MutS domain III; Region: MutS_III; pfam05192 1278073010300 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073010301 Walker A/P-loop; other site 1278073010302 ATP binding site [chemical binding]; other site 1278073010303 Q-loop/lid; other site 1278073010304 ABC transporter signature motif; other site 1278073010305 Walker B; other site 1278073010306 D-loop; other site 1278073010307 H-loop/switch region; other site 1278073010308 Smr domain; Region: Smr; pfam01713 1278073010309 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073010310 binding surface 1278073010311 TPR motif; other site 1278073010312 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1278073010313 cyclase homology domain; Region: CHD; cd07302 1278073010314 nucleotidyl binding site; other site 1278073010315 metal binding site [ion binding]; metal-binding site 1278073010316 dimer interface [polypeptide binding]; other site 1278073010317 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 1278073010318 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1278073010319 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1278073010320 active site 1278073010321 (T/H)XGH motif; other site 1278073010322 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1278073010323 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 1278073010324 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073010325 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1278073010326 Walker A motif; other site 1278073010327 ATP binding site [chemical binding]; other site 1278073010328 Walker B motif; other site 1278073010329 arginine finger; other site 1278073010330 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073010331 Walker A motif; other site 1278073010332 ATP binding site [chemical binding]; other site 1278073010333 Walker B motif; other site 1278073010334 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1278073010335 Yip1 domain; Region: Yip1; pfam04893 1278073010336 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1278073010337 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1278073010338 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1278073010339 HlyD family secretion protein; Region: HlyD_3; pfam13437 1278073010340 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1278073010341 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1278073010342 Walker A/P-loop; other site 1278073010343 ATP binding site [chemical binding]; other site 1278073010344 Q-loop/lid; other site 1278073010345 ABC transporter signature motif; other site 1278073010346 Walker B; other site 1278073010347 D-loop; other site 1278073010348 H-loop/switch region; other site 1278073010349 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1278073010350 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1278073010351 FtsX-like permease family; Region: FtsX; pfam02687 1278073010352 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1278073010353 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1278073010354 FtsX-like permease family; Region: FtsX; pfam02687 1278073010355 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1278073010356 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1278073010357 dimer interface [polypeptide binding]; other site 1278073010358 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1278073010359 catalytic residue [active] 1278073010360 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073010361 dimer interface [polypeptide binding]; other site 1278073010362 phosphorylation site [posttranslational modification] 1278073010363 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073010364 ATP binding site [chemical binding]; other site 1278073010365 Mg2+ binding site [ion binding]; other site 1278073010366 G-X-G motif; other site 1278073010367 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1278073010368 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073010369 active site 1278073010370 phosphorylation site [posttranslational modification] 1278073010371 intermolecular recognition site; other site 1278073010372 dimerization interface [polypeptide binding]; other site 1278073010373 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1278073010374 DNA binding site [nucleotide binding] 1278073010375 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1278073010376 Coenzyme A binding pocket [chemical binding]; other site 1278073010377 von Willebrand factor; Region: vWF_A; pfam12450 1278073010378 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1278073010379 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 1278073010380 metal ion-dependent adhesion site (MIDAS); other site 1278073010381 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 1278073010382 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1278073010383 Protein of unknown function (DUF692); Region: DUF692; cl01263 1278073010384 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1278073010385 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1278073010386 ATP-binding site [chemical binding]; other site 1278073010387 Sugar specificity; other site 1278073010388 Pyrimidine base specificity; other site 1278073010389 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1278073010390 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 1278073010391 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1278073010392 active site 1278073010393 PQQ-like domain; Region: PQQ_2; pfam13360 1278073010394 Restriction endonuclease; Region: Mrr_cat; pfam04471 1278073010395 HEAT repeats; Region: HEAT_2; pfam13646 1278073010396 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1278073010397 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1278073010398 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1278073010399 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1278073010400 pantothenate kinase; Reviewed; Region: PRK13321 1278073010401 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073010402 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073010403 active site 1278073010404 phosphorylation site [posttranslational modification] 1278073010405 intermolecular recognition site; other site 1278073010406 dimerization interface [polypeptide binding]; other site 1278073010407 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 1278073010408 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1278073010409 Putative zinc-finger; Region: zf-HC2; pfam13490 1278073010410 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1278073010411 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073010412 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1278073010413 DNA binding residues [nucleotide binding] 1278073010414 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1278073010415 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1278073010416 hexamer interface [polypeptide binding]; other site 1278073010417 ligand binding site [chemical binding]; other site 1278073010418 putative active site [active] 1278073010419 NAD(P) binding site [chemical binding]; other site 1278073010420 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1278073010421 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1278073010422 FeS/SAM binding site; other site 1278073010423 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1278073010424 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073010425 active site 1278073010426 phosphorylation site [posttranslational modification] 1278073010427 intermolecular recognition site; other site 1278073010428 dimerization interface [polypeptide binding]; other site 1278073010429 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073010430 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073010431 active site 1278073010432 phosphorylation site [posttranslational modification] 1278073010433 intermolecular recognition site; other site 1278073010434 dimerization interface [polypeptide binding]; other site 1278073010435 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1278073010436 putative CheA interaction surface; other site 1278073010437 Two component signalling adaptor domain; Region: CheW; smart00260 1278073010438 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1278073010439 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1278073010440 dimer interface [polypeptide binding]; other site 1278073010441 putative CheW interface [polypeptide binding]; other site 1278073010442 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1278073010443 putative binding surface; other site 1278073010444 active site 1278073010445 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073010446 ATP binding site [chemical binding]; other site 1278073010447 Mg2+ binding site [ion binding]; other site 1278073010448 G-X-G motif; other site 1278073010449 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1278073010450 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1278073010451 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073010452 active site 1278073010453 phosphorylation site [posttranslational modification] 1278073010454 intermolecular recognition site; other site 1278073010455 dimerization interface [polypeptide binding]; other site 1278073010456 CheB methylesterase; Region: CheB_methylest; pfam01339 1278073010457 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 1278073010458 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1278073010459 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1278073010460 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073010461 TPR motif; other site 1278073010462 binding surface 1278073010463 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073010464 binding surface 1278073010465 TPR repeat; Region: TPR_11; pfam13414 1278073010466 TPR motif; other site 1278073010467 TPR repeat; Region: TPR_11; pfam13414 1278073010468 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865 1278073010469 photolyase PhrII; Region: phr2; TIGR00591 1278073010470 DNA photolyase; Region: DNA_photolyase; pfam00875 1278073010471 envelope glycoprotein C; Provisional; Region: PHA03269 1278073010472 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 1278073010473 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073010474 S-adenosylmethionine binding site [chemical binding]; other site 1278073010475 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1278073010476 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1278073010477 Walker A/P-loop; other site 1278073010478 ATP binding site [chemical binding]; other site 1278073010479 Q-loop/lid; other site 1278073010480 ABC transporter signature motif; other site 1278073010481 Walker B; other site 1278073010482 D-loop; other site 1278073010483 H-loop/switch region; other site 1278073010484 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1278073010485 dimer interface [polypeptide binding]; other site 1278073010486 active site 1278073010487 Schiff base residues; other site 1278073010488 RDD family; Region: RDD; pfam06271 1278073010489 D-alanine--D-alanine ligase; Region: D_ala_D_alaTIGR; TIGR01205 1278073010490 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1278073010491 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1278073010492 D-alanine--D-alanine ligase; Region: D_ala_D_alaTIGR; TIGR01205 1278073010493 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1278073010494 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 1278073010495 homodimer interface [polypeptide binding]; other site 1278073010496 homotetramer interface [polypeptide binding]; other site 1278073010497 active site pocket [active] 1278073010498 cleavage site 1278073010499 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1278073010500 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1278073010501 cell division protein ZipA; Provisional; Region: PRK03427 1278073010502 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1278073010503 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 1278073010504 putative active site [active] 1278073010505 Antirepressor CarS; Region: CarS; cd12840 1278073010506 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1278073010507 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073010508 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1278073010509 DNA binding residues [nucleotide binding] 1278073010510 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1278073010511 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1278073010512 putative active site [active] 1278073010513 putative metal binding site [ion binding]; other site 1278073010514 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1278073010515 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1278073010516 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1278073010517 ligand binding site [chemical binding]; other site 1278073010518 flexible hinge region; other site 1278073010519 elongation factor G; Reviewed; Region: PRK00007 1278073010520 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1278073010521 G1 box; other site 1278073010522 putative GEF interaction site [polypeptide binding]; other site 1278073010523 GTP/Mg2+ binding site [chemical binding]; other site 1278073010524 Switch I region; other site 1278073010525 G2 box; other site 1278073010526 G3 box; other site 1278073010527 Switch II region; other site 1278073010528 G4 box; other site 1278073010529 G5 box; other site 1278073010530 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1278073010531 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 1278073010532 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1278073010533 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1278073010534 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1278073010535 ATP binding site [chemical binding]; other site 1278073010536 Mg++ binding site [ion binding]; other site 1278073010537 motif III; other site 1278073010538 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1278073010539 nucleotide binding region [chemical binding]; other site 1278073010540 ATP-binding site [chemical binding]; other site 1278073010541 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1278073010542 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1278073010543 CoenzymeA binding site [chemical binding]; other site 1278073010544 subunit interaction site [polypeptide binding]; other site 1278073010545 PHB binding site; other site 1278073010546 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1278073010547 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1278073010548 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1278073010549 putative catalytic site [active] 1278073010550 putative metal binding site [ion binding]; other site 1278073010551 putative phosphate binding site [ion binding]; other site 1278073010552 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1278073010553 B12 binding site [chemical binding]; other site 1278073010554 cobalt ligand [ion binding]; other site 1278073010555 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 1278073010556 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1278073010557 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 1278073010558 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1278073010559 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1278073010560 Walker A; other site 1278073010561 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1278073010562 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1278073010563 active site 1278073010564 substrate binding site [chemical binding]; other site 1278073010565 coenzyme B12 binding site [chemical binding]; other site 1278073010566 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1278073010567 B12 binding site [chemical binding]; other site 1278073010568 cobalt ligand [ion binding]; other site 1278073010569 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 1278073010570 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 1278073010571 heterodimer interface [polypeptide binding]; other site 1278073010572 substrate interaction site [chemical binding]; other site 1278073010573 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1278073010574 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1278073010575 Protein of unknown function (DUF2378); Region: DUF2378; cl15288 1278073010576 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1278073010577 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1278073010578 Zn binding site [ion binding]; other site 1278073010579 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1278073010580 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 1278073010581 Walker A/P-loop; other site 1278073010582 ATP binding site [chemical binding]; other site 1278073010583 Q-loop/lid; other site 1278073010584 ABC transporter signature motif; other site 1278073010585 Walker B; other site 1278073010586 D-loop; other site 1278073010587 H-loop/switch region; other site 1278073010588 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1278073010589 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1278073010590 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1278073010591 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1278073010592 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073010593 active site 1278073010594 phosphorylation site [posttranslational modification] 1278073010595 intermolecular recognition site; other site 1278073010596 dimerization interface [polypeptide binding]; other site 1278073010597 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1278073010598 DNA binding residues [nucleotide binding] 1278073010599 dimerization interface [polypeptide binding]; other site 1278073010600 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1278073010601 Histidine kinase; Region: HisKA_3; pfam07730 1278073010602 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073010603 ATP binding site [chemical binding]; other site 1278073010604 Mg2+ binding site [ion binding]; other site 1278073010605 G-X-G motif; other site 1278073010606 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1278073010607 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 1278073010608 ATP binding site [chemical binding]; other site 1278073010609 substrate interface [chemical binding]; other site 1278073010610 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1278073010611 CPxP motif; other site 1278073010612 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1278073010613 MoaE interaction surface [polypeptide binding]; other site 1278073010614 thiocarboxylated glycine; other site 1278073010615 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 1278073010616 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 1278073010617 MPN+ (JAMM) motif; other site 1278073010618 Zinc-binding site [ion binding]; other site 1278073010619 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1278073010620 ligand-binding site [chemical binding]; other site 1278073010621 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 1278073010622 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 1278073010623 Ligand Binding Site [chemical binding]; other site 1278073010624 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 1278073010625 Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101 1278073010626 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1278073010627 active site 1278073010628 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1278073010629 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1278073010630 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1278073010631 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073010632 Walker A motif; other site 1278073010633 ATP binding site [chemical binding]; other site 1278073010634 Walker B motif; other site 1278073010635 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1278073010636 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073010637 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073010638 active site 1278073010639 ATP binding site [chemical binding]; other site 1278073010640 substrate binding site [chemical binding]; other site 1278073010641 activation loop (A-loop); other site 1278073010642 AAA ATPase domain; Region: AAA_16; pfam13191 1278073010643 Predicted ATPase [General function prediction only]; Region: COG3899 1278073010644 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1278073010645 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1278073010646 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073010647 ATP binding site [chemical binding]; other site 1278073010648 Mg2+ binding site [ion binding]; other site 1278073010649 G-X-G motif; other site 1278073010650 phytoene desaturase; Region: crtI_fam; TIGR02734 1278073010651 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1278073010652 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 1278073010653 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073010654 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073010655 active site 1278073010656 ATP binding site [chemical binding]; other site 1278073010657 substrate binding site [chemical binding]; other site 1278073010658 activation loop (A-loop); other site 1278073010659 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073010660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073010661 active site 1278073010662 phosphorylation site [posttranslational modification] 1278073010663 intermolecular recognition site; other site 1278073010664 dimerization interface [polypeptide binding]; other site 1278073010665 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1278073010666 cyclase homology domain; Region: CHD; cd07302 1278073010667 nucleotidyl binding site; other site 1278073010668 metal binding site [ion binding]; metal-binding site 1278073010669 dimer interface [polypeptide binding]; other site 1278073010670 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1278073010671 MreB/Mbl protein; Region: MreB_Mbl; pfam06723 1278073010672 nucleotide binding site [chemical binding]; other site 1278073010673 PrkA AAA domain; Region: AAA_PrkA; smart00763 1278073010674 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1278073010675 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1278073010676 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1278073010677 catalytic motif [active] 1278073010678 Zn binding site [ion binding]; other site 1278073010679 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073010680 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073010681 dimer interface [polypeptide binding]; other site 1278073010682 phosphorylation site [posttranslational modification] 1278073010683 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1278073010684 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073010685 active site 1278073010686 phosphorylation site [posttranslational modification] 1278073010687 intermolecular recognition site; other site 1278073010688 dimerization interface [polypeptide binding]; other site 1278073010689 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073010690 Walker A motif; other site 1278073010691 ATP binding site [chemical binding]; other site 1278073010692 Walker B motif; other site 1278073010693 arginine finger; other site 1278073010694 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1278073010695 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 1278073010696 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1278073010697 DTAP/Switch II; other site 1278073010698 Switch I; other site 1278073010699 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 1278073010700 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1278073010701 P loop; other site 1278073010702 Nucleotide binding site [chemical binding]; other site 1278073010703 DTAP/Switch II; other site 1278073010704 Switch I; other site 1278073010705 TPR repeat; Region: TPR_11; pfam13414 1278073010706 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073010707 binding surface 1278073010708 TPR motif; other site 1278073010709 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1278073010710 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1278073010711 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1278073010712 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1278073010713 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1278073010714 homodimer interface [polypeptide binding]; other site 1278073010715 catalytic residue [active] 1278073010716 cytidylate kinase; Provisional; Region: cmk; PRK00023 1278073010717 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1278073010718 CMP-binding site; other site 1278073010719 The sites determining sugar specificity; other site 1278073010720 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1278073010721 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1278073010722 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1278073010723 catalytic residue [active] 1278073010724 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1278073010725 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1278073010726 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1278073010727 Protein of unknown function (DUF721); Region: DUF721; pfam05258 1278073010728 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1278073010729 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1278073010730 phosphopeptide binding site; other site 1278073010731 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1278073010732 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1278073010733 metal binding site [ion binding]; metal-binding site 1278073010734 active site 1278073010735 I-site; other site 1278073010736 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1278073010737 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1278073010738 putative acyl-acceptor binding pocket; other site 1278073010739 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 1278073010740 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1278073010741 putative NAD(P) binding site [chemical binding]; other site 1278073010742 active site 1278073010743 putative substrate binding site [chemical binding]; other site 1278073010744 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1278073010745 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073010746 ATP binding site [chemical binding]; other site 1278073010747 Mg2+ binding site [ion binding]; other site 1278073010748 G-X-G motif; other site 1278073010749 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1278073010750 ATP binding site [chemical binding]; other site 1278073010751 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 1278073010752 WAP-type (Whey Acidic Protein) 'four-disulfide core' Region: WAP; pfam00095 1278073010753 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1278073010754 FHA domain; Region: FHA; pfam00498 1278073010755 phosphopeptide binding site; other site 1278073010756 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 1278073010757 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1278073010758 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073010759 Walker A motif; other site 1278073010760 ATP binding site [chemical binding]; other site 1278073010761 Walker B motif; other site 1278073010762 arginine finger; other site 1278073010763 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1278073010764 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1278073010765 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1278073010766 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073010767 active site 1278073010768 ATP binding site [chemical binding]; other site 1278073010769 substrate binding site [chemical binding]; other site 1278073010770 activation loop (A-loop); other site 1278073010771 phosphofructokinase; Region: PFK_mixed; TIGR02483 1278073010772 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1278073010773 active site 1278073010774 ADP/pyrophosphate binding site [chemical binding]; other site 1278073010775 dimerization interface [polypeptide binding]; other site 1278073010776 allosteric effector site; other site 1278073010777 fructose-1,6-bisphosphate binding site; other site 1278073010778 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1278073010779 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1278073010780 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1278073010781 phosphopeptide binding site; other site 1278073010782 Domain of unknown function (DUF4130; Region: DUF4130; cl14836 1278073010783 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1278073010784 active site 1278073010785 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1278073010786 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1278073010787 active site 1278073010788 catalytic tetrad [active] 1278073010789 acyl-CoA synthetase; Validated; Region: PRK05850 1278073010790 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1278073010791 acyl-activating enzyme (AAE) consensus motif; other site 1278073010792 active site 1278073010793 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1278073010794 Condensation domain; Region: Condensation; pfam00668 1278073010795 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073010796 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073010797 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073010798 acyl-activating enzyme (AAE) consensus motif; other site 1278073010799 AMP binding site [chemical binding]; other site 1278073010800 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073010801 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073010802 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1278073010803 active site 1278073010804 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1278073010805 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1278073010806 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073010807 Condensation domain; Region: Condensation; pfam00668 1278073010808 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073010809 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073010810 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1278073010811 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 1278073010812 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1278073010813 Condensation domain; Region: Condensation; pfam00668 1278073010814 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073010815 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073010816 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073010817 acyl-activating enzyme (AAE) consensus motif; other site 1278073010818 AMP binding site [chemical binding]; other site 1278073010819 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073010820 Condensation domain; Region: Condensation; pfam00668 1278073010821 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1278073010822 Condensation domain; Region: Condensation; pfam00668 1278073010823 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073010824 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073010825 acyl-activating enzyme (AAE) consensus motif; other site 1278073010826 AMP binding site [chemical binding]; other site 1278073010827 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073010828 Condensation domain; Region: Condensation; pfam00668 1278073010829 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1278073010830 Condensation domain; Region: Condensation; pfam00668 1278073010831 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073010832 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073010833 acyl-activating enzyme (AAE) consensus motif; other site 1278073010834 AMP binding site [chemical binding]; other site 1278073010835 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073010836 Condensation domain; Region: Condensation; pfam00668 1278073010837 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073010838 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073010839 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1278073010840 acyl-activating enzyme (AAE) consensus motif; other site 1278073010841 AMP binding site [chemical binding]; other site 1278073010842 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073010843 Condensation domain; Region: Condensation; pfam00668 1278073010844 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073010845 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073010846 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073010847 acyl-activating enzyme (AAE) consensus motif; other site 1278073010848 AMP binding site [chemical binding]; other site 1278073010849 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073010850 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1278073010851 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073010852 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1278073010853 acyl-activating enzyme (AAE) consensus motif; other site 1278073010854 AMP binding site [chemical binding]; other site 1278073010855 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073010856 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1278073010857 active site 1278073010858 metal binding site [ion binding]; metal-binding site 1278073010859 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1278073010860 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1278073010861 ATP binding site [chemical binding]; other site 1278073010862 putative Mg++ binding site [ion binding]; other site 1278073010863 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1278073010864 nucleotide binding region [chemical binding]; other site 1278073010865 ATP-binding site [chemical binding]; other site 1278073010866 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1278073010867 ATP-dependent protease La; Region: lon; TIGR00763 1278073010868 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073010869 Walker A motif; other site 1278073010870 ATP binding site [chemical binding]; other site 1278073010871 Walker B motif; other site 1278073010872 arginine finger; other site 1278073010873 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1278073010874 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 1278073010875 recA bacterial DNA recombination protein; Region: RecA; cl17211 1278073010876 DNA Polymerase Y-family; Region: PolY_like; cd03468 1278073010877 active site 1278073010878 DNA binding site [nucleotide binding] 1278073010879 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1278073010880 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1278073010881 phosphopeptide binding site; other site 1278073010882 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1278073010883 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073010884 NAD(P) binding site [chemical binding]; other site 1278073010885 active site 1278073010886 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1278073010887 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1278073010888 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1278073010889 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1278073010890 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1278073010891 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1278073010892 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1278073010893 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 1278073010894 putative active site [active] 1278073010895 putative PHP Thumb interface [polypeptide binding]; other site 1278073010896 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1278073010897 generic binding surface II; other site 1278073010898 generic binding surface I; other site 1278073010899 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1278073010900 putative active site [active] 1278073010901 catalytic site [active] 1278073010902 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1278073010903 putative active site [active] 1278073010904 catalytic site [active] 1278073010905 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1278073010906 Active site serine [active] 1278073010907 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1278073010908 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073010909 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073010910 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073010911 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073010912 PDZ domain; Region: PDZ_2; pfam13180 1278073010913 protein binding site [polypeptide binding]; other site 1278073010914 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1278073010915 WbqC-like protein family; Region: WbqC; pfam08889 1278073010916 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1278073010917 active site 1278073010918 phosphorylation site [posttranslational modification] 1278073010919 dimerization interface [polypeptide binding]; other site 1278073010920 GAF domain; Region: GAF; pfam01590 1278073010921 GAF domain; Region: GAF_2; pfam13185 1278073010922 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1278073010923 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073010924 phosphorylation site [posttranslational modification] 1278073010925 dimer interface [polypeptide binding]; other site 1278073010926 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073010927 ATP binding site [chemical binding]; other site 1278073010928 Mg2+ binding site [ion binding]; other site 1278073010929 G-X-G motif; other site 1278073010930 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1278073010931 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1278073010932 TAP-like protein; Region: Abhydrolase_4; pfam08386 1278073010933 Amidohydrolase; Region: Amidohydro_4; pfam13147 1278073010934 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1278073010935 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 1278073010936 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 1278073010937 generic binding surface I; other site 1278073010938 generic binding surface II; other site 1278073010939 Lamin Tail Domain; Region: LTD; pfam00932 1278073010940 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1278073010941 putative catalytic site [active] 1278073010942 putative metal binding site [ion binding]; other site 1278073010943 putative phosphate binding site [ion binding]; other site 1278073010944 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1278073010945 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1278073010946 putative acyl-acceptor binding pocket; other site 1278073010947 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1278073010948 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1278073010949 Ligand Binding Site [chemical binding]; other site 1278073010950 classical (c) SDRs; Region: SDR_c; cd05233 1278073010951 NAD(P) binding site [chemical binding]; other site 1278073010952 active site 1278073010953 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1278073010954 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1278073010955 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1278073010956 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 1278073010957 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1278073010958 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1278073010959 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073010960 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1278073010961 DNA binding residues [nucleotide binding] 1278073010962 Uncharacterized conserved protein [Function unknown]; Region: COG0585 1278073010963 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1278073010964 active site 1278073010965 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1278073010966 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1278073010967 phosphopeptide binding site; other site 1278073010968 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1278073010969 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1278073010970 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1278073010971 cyclase homology domain; Region: CHD; cd07302 1278073010972 nucleotidyl binding site; other site 1278073010973 metal binding site [ion binding]; metal-binding site 1278073010974 dimer interface [polypeptide binding]; other site 1278073010975 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073010976 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073010977 active site 1278073010978 ATP binding site [chemical binding]; other site 1278073010979 substrate binding site [chemical binding]; other site 1278073010980 activation loop (A-loop); other site 1278073010981 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 1278073010982 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1278073010983 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073010984 Walker A motif; other site 1278073010985 ATP binding site [chemical binding]; other site 1278073010986 Walker B motif; other site 1278073010987 arginine finger; other site 1278073010988 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1278073010989 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1278073010990 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1278073010991 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1278073010992 P-loop; other site 1278073010993 Magnesium ion binding site [ion binding]; other site 1278073010994 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1278073010995 Magnesium ion binding site [ion binding]; other site 1278073010996 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 1278073010997 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1278073010998 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1278073010999 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1278073011000 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1278073011001 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1278073011002 active site 1278073011003 dimer interface [polypeptide binding]; other site 1278073011004 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1278073011005 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1278073011006 active site 1278073011007 FMN binding site [chemical binding]; other site 1278073011008 substrate binding site [chemical binding]; other site 1278073011009 3Fe-4S cluster binding site [ion binding]; other site 1278073011010 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1278073011011 domain interface; other site 1278073011012 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1278073011013 putative active site [active] 1278073011014 nucleotide binding site [chemical binding]; other site 1278073011015 nudix motif; other site 1278073011016 putative metal binding site [ion binding]; other site 1278073011017 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1278073011018 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 1278073011019 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1278073011020 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 1278073011021 Outer membrane receptor for monomeric catechols [Inorganic ion transport and metabolism]; Region: Fiu; COG4774 1278073011022 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1278073011023 N-terminal plug; other site 1278073011024 ligand-binding site [chemical binding]; other site 1278073011025 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 1278073011026 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1278073011027 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1278073011028 ATP binding site [chemical binding]; other site 1278073011029 Mg++ binding site [ion binding]; other site 1278073011030 motif III; other site 1278073011031 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1278073011032 nucleotide binding region [chemical binding]; other site 1278073011033 ATP-binding site [chemical binding]; other site 1278073011034 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 1278073011035 RNA binding site [nucleotide binding]; other site 1278073011036 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1278073011037 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1278073011038 active site 1278073011039 metal binding site [ion binding]; metal-binding site 1278073011040 Universal stress protein family; Region: Usp; pfam00582 1278073011041 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1278073011042 PLD-like domain; Region: PLDc_2; pfam13091 1278073011043 putative active site [active] 1278073011044 catalytic site [active] 1278073011045 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1278073011046 PLD-like domain; Region: PLDc_2; pfam13091 1278073011047 putative active site [active] 1278073011048 catalytic site [active] 1278073011049 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1278073011050 mce related protein; Region: MCE; pfam02470 1278073011051 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1278073011052 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073011053 Walker A/P-loop; other site 1278073011054 ATP binding site [chemical binding]; other site 1278073011055 Q-loop/lid; other site 1278073011056 ABC transporter signature motif; other site 1278073011057 Walker B; other site 1278073011058 D-loop; other site 1278073011059 H-loop/switch region; other site 1278073011060 Permease; Region: Permease; pfam02405 1278073011061 Permease; Region: Permease; pfam02405 1278073011062 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1278073011063 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073011064 Walker A/P-loop; other site 1278073011065 ATP binding site [chemical binding]; other site 1278073011066 Q-loop/lid; other site 1278073011067 ABC transporter signature motif; other site 1278073011068 Walker B; other site 1278073011069 D-loop; other site 1278073011070 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 1278073011071 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 1278073011072 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1278073011073 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1278073011074 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1278073011075 HlyD family secretion protein; Region: HlyD_3; pfam13437 1278073011076 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1278073011077 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1278073011078 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 1278073011079 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1278073011080 catalytic residues [active] 1278073011081 dimer interface [polypeptide binding]; other site 1278073011082 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1278073011083 ABC1 family; Region: ABC1; cl17513 1278073011084 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1278073011085 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1278073011086 MutS domain I; Region: MutS_I; pfam01624 1278073011087 MutS domain II; Region: MutS_II; pfam05188 1278073011088 MutS domain III; Region: MutS_III; pfam05192 1278073011089 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1278073011090 Walker A/P-loop; other site 1278073011091 ATP binding site [chemical binding]; other site 1278073011092 Q-loop/lid; other site 1278073011093 ABC transporter signature motif; other site 1278073011094 Walker B; other site 1278073011095 D-loop; other site 1278073011096 H-loop/switch region; other site 1278073011097 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1278073011098 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1278073011099 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1278073011100 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1278073011101 active site 1278073011102 metal binding site [ion binding]; metal-binding site 1278073011103 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 1278073011104 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073011105 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1278073011106 NAD(P) binding site [chemical binding]; other site 1278073011107 active site 1278073011108 Cupin; Region: Cupin_6; pfam12852 1278073011109 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1278073011110 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1278073011111 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1278073011112 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1278073011113 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1278073011114 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1278073011115 AAA domain; Region: AAA_17; pfam13207 1278073011116 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1278073011117 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1278073011118 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1278073011119 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1278073011120 HlyD family secretion protein; Region: HlyD_3; pfam13437 1278073011121 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1278073011122 Protein export membrane protein; Region: SecD_SecF; cl14618 1278073011123 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1278073011124 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1278073011125 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1278073011126 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1278073011127 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1278073011128 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1278073011129 putative active site [active] 1278073011130 putative CoA binding site [chemical binding]; other site 1278073011131 putative AMP binding site [chemical binding]; other site 1278073011132 Helix-turn-helix domain; Region: HTH_18; pfam12833 1278073011133 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1278073011134 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1278073011135 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1278073011136 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1278073011137 N-terminal domain interface [polypeptide binding]; other site 1278073011138 dimer interface [polypeptide binding]; other site 1278073011139 substrate binding pocket (H-site) [chemical binding]; other site 1278073011140 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1278073011141 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1278073011142 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1278073011143 putative effector binding pocket; other site 1278073011144 dimerization interface [polypeptide binding]; other site 1278073011145 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1278073011146 nucleophilic elbow; other site 1278073011147 catalytic triad; other site 1278073011148 Beta-lactamase; Region: Beta-lactamase; pfam00144 1278073011149 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1278073011150 major facilitator superfamily transporter; Provisional; Region: PRK05122 1278073011151 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1278073011152 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1278073011153 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1278073011154 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 1278073011155 putative substrate binding pocket [chemical binding]; other site 1278073011156 putative dimerization interface [polypeptide binding]; other site 1278073011157 Synapsin, ATP binding domain; Region: Synapsin_C; pfam02750 1278073011158 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1278073011159 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1278073011160 putative sugar binding sites [chemical binding]; other site 1278073011161 Q-X-W motif; other site 1278073011162 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 1278073011163 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1278073011164 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073011165 dimer interface [polypeptide binding]; other site 1278073011166 phosphorylation site [posttranslational modification] 1278073011167 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073011168 ATP binding site [chemical binding]; other site 1278073011169 Mg2+ binding site [ion binding]; other site 1278073011170 G-X-G motif; other site 1278073011171 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 1278073011172 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073011173 active site 1278073011174 phosphorylation site [posttranslational modification] 1278073011175 intermolecular recognition site; other site 1278073011176 dimerization interface [polypeptide binding]; other site 1278073011177 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1278073011178 DNA binding residues [nucleotide binding] 1278073011179 dimerization interface [polypeptide binding]; other site 1278073011180 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1278073011181 Kelch domain; Region: Kelch; smart00612 1278073011182 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1278073011183 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1278073011184 Kelch domain; Region: Kelch; smart00612 1278073011185 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 1278073011186 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 1278073011187 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 1278073011188 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 1278073011189 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1278073011190 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073011191 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1278073011192 DNA binding residues [nucleotide binding] 1278073011193 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 1278073011194 Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135 1278073011195 Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135 1278073011196 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1278073011197 WHG domain; Region: WHG; pfam13305 1278073011198 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1278073011199 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 1278073011200 putative active site [active] 1278073011201 putative FMN binding site [chemical binding]; other site 1278073011202 putative substrate binding site [chemical binding]; other site 1278073011203 putative catalytic residue [active] 1278073011204 Histidine kinase; Region: His_kinase; pfam06580 1278073011205 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073011206 ATP binding site [chemical binding]; other site 1278073011207 Mg2+ binding site [ion binding]; other site 1278073011208 G-X-G motif; other site 1278073011209 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1278073011210 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073011211 active site 1278073011212 phosphorylation site [posttranslational modification] 1278073011213 intermolecular recognition site; other site 1278073011214 dimerization interface [polypeptide binding]; other site 1278073011215 LytTr DNA-binding domain; Region: LytTR; pfam04397 1278073011216 Predicted peptidase [General function prediction only]; Region: COG4099 1278073011217 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1278073011218 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1278073011219 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1278073011220 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 1278073011221 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 1278073011222 PA/protease or protease-like domain interface [polypeptide binding]; other site 1278073011223 M28 Zn-Peptidases containing a PA domain insert and associated with a PDZ domain; Region: M28_like_PA_PDZ_associated; cd05663 1278073011224 Peptidase family M28; Region: Peptidase_M28; pfam04389 1278073011225 metal binding site [ion binding]; metal-binding site 1278073011226 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1278073011227 pyruvate carboxylase; Reviewed; Region: PRK12999 1278073011228 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1278073011229 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1278073011230 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1278073011231 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 1278073011232 active site 1278073011233 catalytic residues [active] 1278073011234 metal binding site [ion binding]; metal-binding site 1278073011235 homodimer binding site [polypeptide binding]; other site 1278073011236 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1278073011237 carboxyltransferase (CT) interaction site; other site 1278073011238 biotinylation site [posttranslational modification]; other site 1278073011239 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1278073011240 Cytochrome P450; Region: p450; pfam00067 1278073011241 benzoate transport; Region: 2A0115; TIGR00895 1278073011242 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1278073011243 putative substrate translocation pore; other site 1278073011244 Beta-propeller repeat; Region: SBBP; pfam06739 1278073011245 Predicted integral membrane protein [Function unknown]; Region: COG5616 1278073011246 Predicted integral membrane protein [Function unknown]; Region: COG5616 1278073011247 Histidine kinase; Region: His_kinase; pfam06580 1278073011248 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1278073011249 Mg2+ binding site [ion binding]; other site 1278073011250 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1278073011251 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073011252 active site 1278073011253 phosphorylation site [posttranslational modification] 1278073011254 intermolecular recognition site; other site 1278073011255 dimerization interface [polypeptide binding]; other site 1278073011256 LytTr DNA-binding domain; Region: LytTR; smart00850 1278073011257 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 1278073011258 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1278073011259 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 1278073011260 active site 1278073011261 nucleophile elbow; other site 1278073011262 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1278073011263 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1278073011264 Small hydrophilic plant seed protein; Region: LEA_5; pfam00477 1278073011265 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1278073011266 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1278073011267 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1278073011268 active site 1278073011269 Int/Topo IB signature motif; other site 1278073011270 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1278073011271 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1278073011272 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1278073011273 active site 1278073011274 HIGH motif; other site 1278073011275 dimer interface [polypeptide binding]; other site 1278073011276 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1278073011277 KMSKS motif; other site 1278073011278 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1278073011279 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1278073011280 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1278073011281 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1278073011282 RNA binding surface [nucleotide binding]; other site 1278073011283 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1278073011284 active site 1278073011285 HEAT repeats; Region: HEAT_2; pfam13646 1278073011286 TPR repeat; Region: TPR_11; pfam13414 1278073011287 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073011288 binding surface 1278073011289 TPR motif; other site 1278073011290 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1278073011291 bacteriocin-type transport-associated protein; Region: cyc_nuc_ocin; TIGR03896 1278073011292 ligand binding site [chemical binding]; other site 1278073011293 flexible hinge region; other site 1278073011294 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1278073011295 ligand binding site [chemical binding]; other site 1278073011296 flexible hinge region; other site 1278073011297 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1278073011298 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1278073011299 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 1278073011300 transmembrane helices; other site 1278073011301 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 1278073011302 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1278073011303 ATP binding site [chemical binding]; other site 1278073011304 putative Mg++ binding site [ion binding]; other site 1278073011305 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1278073011306 nucleotide binding region [chemical binding]; other site 1278073011307 ATP-binding site [chemical binding]; other site 1278073011308 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1278073011309 RNase_H superfamily; Region: RNase_H_2; pfam13482 1278073011310 active site 1278073011311 substrate binding site [chemical binding]; other site 1278073011312 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1278073011313 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1278073011314 bile acid transporter; Region: bass; TIGR00841 1278073011315 Sodium Bile acid symporter family; Region: SBF; pfam01758 1278073011316 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1278073011317 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1278073011318 active site 1278073011319 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1278073011320 catalytic triad [active] 1278073011321 dimer interface [polypeptide binding]; other site 1278073011322 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1278073011323 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1278073011324 catalytic triad [active] 1278073011325 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1278073011326 dimerization interface [polypeptide binding]; other site 1278073011327 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1278073011328 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1278073011329 dimer interface [polypeptide binding]; other site 1278073011330 putative CheW interface [polypeptide binding]; other site 1278073011331 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1278073011332 Zn binding site [ion binding]; other site 1278073011333 MarR family; Region: MarR_2; pfam12802 1278073011334 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1278073011335 SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133 1278073011336 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1278073011337 Coenzyme A binding pocket [chemical binding]; other site 1278073011338 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1278073011339 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1278073011340 Endonuclease/Exonuclease/phosphatase family; Region: Exo_endo_phos; pfam03372 1278073011341 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1278073011342 putative catalytic site [active] 1278073011343 putative phosphate binding site [ion binding]; other site 1278073011344 putative metal binding site [ion binding]; other site 1278073011345 H+ Antiporter protein; Region: 2A0121; TIGR00900 1278073011346 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1278073011347 putative substrate translocation pore; other site 1278073011348 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1278073011349 Glycerate kinase family; Region: Gly_kinase; cl00841 1278073011350 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1278073011351 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1278073011352 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1278073011353 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1278073011354 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1278073011355 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073011356 Walker A/P-loop; other site 1278073011357 ATP binding site [chemical binding]; other site 1278073011358 Q-loop/lid; other site 1278073011359 ABC transporter signature motif; other site 1278073011360 Walker B; other site 1278073011361 D-loop; other site 1278073011362 H-loop/switch region; other site 1278073011363 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1278073011364 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1278073011365 Walker A/P-loop; other site 1278073011366 ATP binding site [chemical binding]; other site 1278073011367 Q-loop/lid; other site 1278073011368 ABC transporter signature motif; other site 1278073011369 Walker B; other site 1278073011370 D-loop; other site 1278073011371 H-loop/switch region; other site 1278073011372 HlyD family secretion protein; Region: HlyD_3; pfam13437 1278073011373 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1278073011374 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1278073011375 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073011376 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073011377 dimer interface [polypeptide binding]; other site 1278073011378 phosphorylation site [posttranslational modification] 1278073011379 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073011380 ATP binding site [chemical binding]; other site 1278073011381 Mg2+ binding site [ion binding]; other site 1278073011382 G-X-G motif; other site 1278073011383 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1278073011384 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073011385 active site 1278073011386 phosphorylation site [posttranslational modification] 1278073011387 intermolecular recognition site; other site 1278073011388 dimerization interface [polypeptide binding]; other site 1278073011389 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073011390 Walker A motif; other site 1278073011391 ATP binding site [chemical binding]; other site 1278073011392 Walker B motif; other site 1278073011393 arginine finger; other site 1278073011394 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1278073011395 Predicted acyl esterases [General function prediction only]; Region: COG2936 1278073011396 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 1278073011397 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 1278073011398 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 1278073011399 putative active site [active] 1278073011400 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1278073011401 tandem repeat interface [polypeptide binding]; other site 1278073011402 oligomer interface [polypeptide binding]; other site 1278073011403 active site residues [active] 1278073011404 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1278073011405 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1278073011406 tandem repeat interface [polypeptide binding]; other site 1278073011407 oligomer interface [polypeptide binding]; other site 1278073011408 active site residues [active] 1278073011409 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 1278073011410 Domain of unknown function DUF59; Region: DUF59; pfam01883 1278073011411 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1278073011412 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1278073011413 Walker A motif; other site 1278073011414 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 1278073011415 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1278073011416 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1278073011417 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 1278073011418 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1278073011419 substrate binding site [chemical binding]; other site 1278073011420 oxyanion hole (OAH) forming residues; other site 1278073011421 trimer interface [polypeptide binding]; other site 1278073011422 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1278073011423 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 1278073011424 FAD binding site [chemical binding]; other site 1278073011425 homotetramer interface [polypeptide binding]; other site 1278073011426 substrate binding pocket [chemical binding]; other site 1278073011427 catalytic base [active] 1278073011428 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1278073011429 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1278073011430 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1278073011431 active site 1278073011432 hypothetical protein; Provisional; Region: PHA03169 1278073011433 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1278073011434 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1278073011435 RNA binding site [nucleotide binding]; other site 1278073011436 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1278073011437 RNA binding site [nucleotide binding]; other site 1278073011438 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1278073011439 RNA binding site [nucleotide binding]; other site 1278073011440 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1278073011441 RNA binding site [nucleotide binding]; other site 1278073011442 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1278073011443 RNA binding site [nucleotide binding]; other site 1278073011444 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1278073011445 RNA binding site [nucleotide binding]; other site 1278073011446 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1278073011447 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1278073011448 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1278073011449 putative acyltransferase; Provisional; Region: PRK05790 1278073011450 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1278073011451 dimer interface [polypeptide binding]; other site 1278073011452 active site 1278073011453 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1278073011454 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1278073011455 Myxococcus xanthus paralogous domain TIGR02266; Region: gmx_TIGR02266 1278073011456 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1278073011457 TRAM domain; Region: TRAM; cl01282 1278073011458 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073011459 S-adenosylmethionine binding site [chemical binding]; other site 1278073011460 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 1278073011461 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 1278073011462 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1278073011463 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1278073011464 cofactor binding site; other site 1278073011465 DNA binding site [nucleotide binding] 1278073011466 substrate interaction site [chemical binding]; other site 1278073011467 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1278073011468 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1278073011469 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1278073011470 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1278073011471 FeS/SAM binding site; other site 1278073011472 TRAM domain; Region: TRAM; cl01282 1278073011473 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1278073011474 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1278073011475 trimer interface [polypeptide binding]; other site 1278073011476 putative metal binding site [ion binding]; other site 1278073011477 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1278073011478 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1278073011479 ligand binding site [chemical binding]; other site 1278073011480 flexible hinge region; other site 1278073011481 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1278073011482 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1278073011483 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1278073011484 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 1278073011485 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1278073011486 acyl-CoA synthetase; Validated; Region: PRK05850 1278073011487 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1278073011488 acyl-activating enzyme (AAE) consensus motif; other site 1278073011489 active site 1278073011490 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073011491 Condensation domain; Region: Condensation; pfam00668 1278073011492 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073011493 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073011494 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073011495 acyl-activating enzyme (AAE) consensus motif; other site 1278073011496 AMP binding site [chemical binding]; other site 1278073011497 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1278073011498 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073011499 S-adenosylmethionine binding site [chemical binding]; other site 1278073011500 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1278073011501 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073011502 Condensation domain; Region: Condensation; pfam00668 1278073011503 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073011504 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073011505 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073011506 acyl-activating enzyme (AAE) consensus motif; other site 1278073011507 AMP binding site [chemical binding]; other site 1278073011508 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073011509 Condensation domain; Region: Condensation; pfam00668 1278073011510 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073011511 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073011512 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1278073011513 acyl-activating enzyme (AAE) consensus motif; other site 1278073011514 AMP binding site [chemical binding]; other site 1278073011515 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073011516 Condensation domain; Region: Condensation; pfam00668 1278073011517 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073011518 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073011519 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073011520 acyl-activating enzyme (AAE) consensus motif; other site 1278073011521 AMP binding site [chemical binding]; other site 1278073011522 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073011523 Condensation domain; Region: Condensation; pfam00668 1278073011524 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073011525 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073011526 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073011527 acyl-activating enzyme (AAE) consensus motif; other site 1278073011528 AMP binding site [chemical binding]; other site 1278073011529 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073011530 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1278073011531 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073011532 active site 1278073011533 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1278073011534 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1278073011535 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073011536 Condensation domain; Region: Condensation; pfam00668 1278073011537 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073011538 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073011539 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1278073011540 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 1278073011541 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1278073011542 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1278073011543 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1278073011544 Condensation domain; Region: Condensation; pfam00668 1278073011545 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073011546 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073011547 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073011548 acyl-activating enzyme (AAE) consensus motif; other site 1278073011549 AMP binding site [chemical binding]; other site 1278073011550 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073011551 Condensation domain; Region: Condensation; pfam00668 1278073011552 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073011553 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073011554 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1278073011555 acyl-activating enzyme (AAE) consensus motif; other site 1278073011556 AMP binding site [chemical binding]; other site 1278073011557 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073011558 Condensation domain; Region: Condensation; pfam00668 1278073011559 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073011560 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073011561 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1278073011562 acyl-activating enzyme (AAE) consensus motif; other site 1278073011563 AMP binding site [chemical binding]; other site 1278073011564 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073011565 Condensation domain; Region: Condensation; pfam00668 1278073011566 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073011567 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073011568 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073011569 acyl-activating enzyme (AAE) consensus motif; other site 1278073011570 AMP binding site [chemical binding]; other site 1278073011571 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073011572 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1278073011573 PilZ domain; Region: PilZ; cl01260 1278073011574 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1278073011575 nucleotide binding site [chemical binding]; other site 1278073011576 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1278073011577 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1278073011578 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1278073011579 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1278073011580 active site 1278073011581 GMP synthase; Reviewed; Region: guaA; PRK00074 1278073011582 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1278073011583 AMP/PPi binding site [chemical binding]; other site 1278073011584 candidate oxyanion hole; other site 1278073011585 catalytic triad [active] 1278073011586 potential glutamine specificity residues [chemical binding]; other site 1278073011587 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1278073011588 ATP Binding subdomain [chemical binding]; other site 1278073011589 Ligand Binding sites [chemical binding]; other site 1278073011590 Dimerization subdomain; other site 1278073011591 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1278073011592 Peptidase S46; Region: Peptidase_S46; pfam10459 1278073011593 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1278073011594 Domain of unknown function DUF87; Region: DUF87; pfam01935 1278073011595 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1278073011596 catalytic residue [active] 1278073011597 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1278073011598 Protein of unknown function (DUF3014); Region: DUF3014; pfam11219 1278073011599 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 1278073011600 RNase_H superfamily; Region: RNase_H_2; pfam13482 1278073011601 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1278073011602 active site 1278073011603 8-oxo-dGMP binding site [chemical binding]; other site 1278073011604 nudix motif; other site 1278073011605 metal binding site [ion binding]; metal-binding site 1278073011606 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 1278073011607 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1278073011608 Trp docking motif [polypeptide binding]; other site 1278073011609 active site 1278073011610 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1278073011611 GTP-binding protein Der; Reviewed; Region: PRK00093 1278073011612 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1278073011613 G1 box; other site 1278073011614 GTP/Mg2+ binding site [chemical binding]; other site 1278073011615 Switch I region; other site 1278073011616 G2 box; other site 1278073011617 Switch II region; other site 1278073011618 G3 box; other site 1278073011619 G4 box; other site 1278073011620 G5 box; other site 1278073011621 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1278073011622 G1 box; other site 1278073011623 GTP/Mg2+ binding site [chemical binding]; other site 1278073011624 Switch I region; other site 1278073011625 G2 box; other site 1278073011626 G3 box; other site 1278073011627 Switch II region; other site 1278073011628 G4 box; other site 1278073011629 G5 box; other site 1278073011630 GTPase Era; Reviewed; Region: era; PRK00089 1278073011631 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1278073011632 G1 box; other site 1278073011633 GTP/Mg2+ binding site [chemical binding]; other site 1278073011634 Switch I region; other site 1278073011635 G2 box; other site 1278073011636 Switch II region; other site 1278073011637 G3 box; other site 1278073011638 G4 box; other site 1278073011639 G5 box; other site 1278073011640 KH domain; Region: KH_2; pfam07650 1278073011641 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 1278073011642 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1278073011643 active site 1278073011644 ribonuclease III; Reviewed; Region: rnc; PRK00102 1278073011645 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1278073011646 dimerization interface [polypeptide binding]; other site 1278073011647 active site 1278073011648 metal binding site [ion binding]; metal-binding site 1278073011649 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1278073011650 dsRNA binding site [nucleotide binding]; other site 1278073011651 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1278073011652 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1278073011653 active site 1278073011654 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1278073011655 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1278073011656 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1278073011657 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1278073011658 enoyl-CoA hydratase; Provisional; Region: PRK07657 1278073011659 substrate binding site [chemical binding]; other site 1278073011660 oxyanion hole (OAH) forming residues; other site 1278073011661 trimer interface [polypeptide binding]; other site 1278073011662 Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978 1278073011663 tellurium resistance terB-like protein; Region: terB_like; cd07177 1278073011664 metal binding site [ion binding]; metal-binding site 1278073011665 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1278073011666 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1278073011667 dimer interface [polypeptide binding]; other site 1278073011668 putative CheW interface [polypeptide binding]; other site 1278073011669 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 1278073011670 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 1278073011671 active site 1278073011672 catalytic residues [active] 1278073011673 metal binding site [ion binding]; metal-binding site 1278073011674 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073011675 S-adenosylmethionine binding site [chemical binding]; other site 1278073011676 aminotransferase; Validated; Region: PRK07777 1278073011677 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1278073011678 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1278073011679 homodimer interface [polypeptide binding]; other site 1278073011680 catalytic residue [active] 1278073011681 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1278073011682 active site 1278073011683 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 1278073011684 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 1278073011685 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1278073011686 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1278073011687 substrate-cofactor binding pocket; other site 1278073011688 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1278073011689 catalytic residue [active] 1278073011690 Ubiquitin-like proteins; Region: UBQ; cl00155 1278073011691 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1278073011692 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073011693 NAD(P) binding site [chemical binding]; other site 1278073011694 active site 1278073011695 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 1278073011696 Outer membrane efflux protein; Region: OEP; pfam02321 1278073011697 Outer membrane efflux protein; Region: OEP; pfam02321 1278073011698 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 1278073011699 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 1278073011700 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073011701 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073011702 active site 1278073011703 phosphorylation site [posttranslational modification] 1278073011704 intermolecular recognition site; other site 1278073011705 dimerization interface [polypeptide binding]; other site 1278073011706 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1278073011707 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073011708 TPR motif; other site 1278073011709 binding surface 1278073011710 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073011711 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073011712 active site 1278073011713 phosphorylation site [posttranslational modification] 1278073011714 intermolecular recognition site; other site 1278073011715 dimerization interface [polypeptide binding]; other site 1278073011716 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1278073011717 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1278073011718 metal binding site [ion binding]; metal-binding site 1278073011719 active site 1278073011720 I-site; other site 1278073011721 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073011722 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073011723 active site 1278073011724 phosphorylation site [posttranslational modification] 1278073011725 intermolecular recognition site; other site 1278073011726 dimerization interface [polypeptide binding]; other site 1278073011727 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1278073011728 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1278073011729 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1278073011730 HprK-related kinase A; Region: HprK_rel_A; TIGR04352 1278073011731 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 1278073011732 PQQ-like domain; Region: PQQ_2; pfam13360 1278073011733 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1278073011734 active site 1278073011735 Trp docking motif [polypeptide binding]; other site 1278073011736 outer membrane lipoprotein Blc; Provisional; Region: PRK10477 1278073011737 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 1278073011738 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 1278073011739 Catalytic site [active] 1278073011740 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1278073011741 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1278073011742 dimer interface [polypeptide binding]; other site 1278073011743 motif 1; other site 1278073011744 active site 1278073011745 motif 2; other site 1278073011746 motif 3; other site 1278073011747 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1278073011748 anticodon binding site; other site 1278073011749 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 1278073011750 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1278073011751 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 1278073011752 active site 1278073011753 metal binding site [ion binding]; metal-binding site 1278073011754 Myxococcus xanthus paralogous domain TIGR02266; Region: gmx_TIGR02266 1278073011755 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1278073011756 substrate binding site [chemical binding]; other site 1278073011757 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1278073011758 ATP binding site [chemical binding]; other site 1278073011759 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1278073011760 mce related protein; Region: MCE; pfam02470 1278073011761 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1278073011762 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1278073011763 Walker A/P-loop; other site 1278073011764 ATP binding site [chemical binding]; other site 1278073011765 Q-loop/lid; other site 1278073011766 ABC transporter signature motif; other site 1278073011767 Walker B; other site 1278073011768 D-loop; other site 1278073011769 H-loop/switch region; other site 1278073011770 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1278073011771 Permease; Region: Permease; pfam02405 1278073011772 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1278073011773 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1278073011774 active site 1278073011775 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1278073011776 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1278073011777 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1278073011778 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1278073011779 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1278073011780 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1278073011781 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1278073011782 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073011783 active site 1278073011784 phosphorylation site [posttranslational modification] 1278073011785 intermolecular recognition site; other site 1278073011786 dimerization interface [polypeptide binding]; other site 1278073011787 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1278073011788 DNA binding residues [nucleotide binding] 1278073011789 dimerization interface [polypeptide binding]; other site 1278073011790 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073011791 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073011792 active site 1278073011793 ATP binding site [chemical binding]; other site 1278073011794 substrate binding site [chemical binding]; other site 1278073011795 activation loop (A-loop); other site 1278073011796 PEGA domain; Region: PEGA; pfam08308 1278073011797 5' nucleotidase family; Region: 5_nucleotid; pfam05761 1278073011798 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 1278073011799 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1278073011800 GAF domain; Region: GAF; pfam01590 1278073011801 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1278073011802 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1278073011803 metal binding site [ion binding]; metal-binding site 1278073011804 active site 1278073011805 I-site; other site 1278073011806 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1278073011807 Septum formation initiator; Region: DivIC; pfam04977 1278073011808 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1278073011809 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1278073011810 catalytic residues [active] 1278073011811 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1278073011812 metal binding site 2 [ion binding]; metal-binding site 1278073011813 putative DNA binding helix; other site 1278073011814 metal binding site 1 [ion binding]; metal-binding site 1278073011815 dimer interface [polypeptide binding]; other site 1278073011816 structural Zn2+ binding site [ion binding]; other site 1278073011817 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 1278073011818 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 1278073011819 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 1278073011820 active site 1278073011821 PHP-associated; Region: PHP_C; pfam13263 1278073011822 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 1278073011823 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 1278073011824 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1278073011825 active site 1278073011826 catalytic site [active] 1278073011827 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073011828 active site 1278073011829 ATP binding site [chemical binding]; other site 1278073011830 substrate binding site [chemical binding]; other site 1278073011831 activation loop (A-loop); other site 1278073011832 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1278073011833 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073011834 TPR motif; other site 1278073011835 Protein kinase domain; Region: Pkinase; pfam00069 1278073011836 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073011837 active site 1278073011838 ATP binding site [chemical binding]; other site 1278073011839 substrate binding site [chemical binding]; other site 1278073011840 activation loop (A-loop); other site 1278073011841 Protein kinase domain; Region: Pkinase; pfam00069 1278073011842 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073011843 active site 1278073011844 ATP binding site [chemical binding]; other site 1278073011845 substrate binding site [chemical binding]; other site 1278073011846 activation loop (A-loop); other site 1278073011847 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073011848 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073011849 active site 1278073011850 ATP binding site [chemical binding]; other site 1278073011851 substrate binding site [chemical binding]; other site 1278073011852 activation loop (A-loop); other site 1278073011853 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1278073011854 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073011855 binding surface 1278073011856 TPR motif; other site 1278073011857 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1278073011858 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1278073011859 phosphopeptide binding site; other site 1278073011860 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1278073011861 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073011862 Walker A motif; other site 1278073011863 ATP binding site [chemical binding]; other site 1278073011864 Walker B motif; other site 1278073011865 arginine finger; other site 1278073011866 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1278073011867 Domain of unknown function (DUF4382); Region: DUF4382; pfam14321 1278073011868 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073011869 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073011870 dimer interface [polypeptide binding]; other site 1278073011871 phosphorylation site [posttranslational modification] 1278073011872 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073011873 ATP binding site [chemical binding]; other site 1278073011874 Mg2+ binding site [ion binding]; other site 1278073011875 G-X-G motif; other site 1278073011876 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1278073011877 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073011878 active site 1278073011879 phosphorylation site [posttranslational modification] 1278073011880 intermolecular recognition site; other site 1278073011881 dimerization interface [polypeptide binding]; other site 1278073011882 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1278073011883 DNA binding site [nucleotide binding] 1278073011884 RNA polymerase sigma factor; Provisional; Region: PRK12519 1278073011885 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073011886 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1278073011887 DNA binding residues [nucleotide binding] 1278073011888 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1278073011889 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 1278073011890 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1278073011891 active site 1278073011892 homodimer interface [polypeptide binding]; other site 1278073011893 catalytic site [active] 1278073011894 acceptor binding site [chemical binding]; other site 1278073011895 trehalose synthase; Region: treS_nterm; TIGR02456 1278073011896 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 1278073011897 active site 1278073011898 catalytic site [active] 1278073011899 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 1278073011900 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 1278073011901 glycogen branching enzyme; Provisional; Region: PRK05402 1278073011902 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 1278073011903 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1278073011904 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1278073011905 active site 1278073011906 catalytic site [active] 1278073011907 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1278073011908 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 1278073011909 active site 1278073011910 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1278073011911 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1278073011912 active site 1278073011913 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1278073011914 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1278073011915 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1278073011916 substrate binding pocket [chemical binding]; other site 1278073011917 dimerization interface [polypeptide binding]; other site 1278073011918 dimerization interface [polypeptide binding]; other site 1278073011919 AIG2-like family; Region: AIG2_2; pfam13772 1278073011920 putative catalytic residue [active] 1278073011921 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1278073011922 dimerization interface [polypeptide binding]; other site 1278073011923 putative Zn2+ binding site [ion binding]; other site 1278073011924 putative DNA binding site [nucleotide binding]; other site 1278073011925 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1278073011926 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1278073011927 substrate binding pocket [chemical binding]; other site 1278073011928 chain length determination region; other site 1278073011929 substrate-Mg2+ binding site; other site 1278073011930 catalytic residues [active] 1278073011931 aspartate-rich region 1; other site 1278073011932 active site lid residues [active] 1278073011933 aspartate-rich region 2; other site 1278073011934 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1278073011935 dimerization interface [polypeptide binding]; other site 1278073011936 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1278073011937 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1278073011938 dimer interface [polypeptide binding]; other site 1278073011939 putative CheW interface [polypeptide binding]; other site 1278073011940 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1278073011941 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 1278073011942 metal binding site [ion binding]; metal-binding site 1278073011943 putative dimer interface [polypeptide binding]; other site 1278073011944 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 1278073011945 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1278073011946 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1278073011947 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1278073011948 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1278073011949 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 1278073011950 Predicted Permease Membrane Region; Region: Asp-Al_Ex; cl06061 1278073011951 TrkA-C domain; Region: TrkA_C; pfam02080 1278073011952 TrkA-C domain; Region: TrkA_C; pfam02080 1278073011953 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1278073011954 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1278073011955 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1278073011956 motif II; other site 1278073011957 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1278073011958 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1278073011959 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 1278073011960 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1278073011961 non-specific DNA binding site [nucleotide binding]; other site 1278073011962 salt bridge; other site 1278073011963 sequence-specific DNA binding site [nucleotide binding]; other site 1278073011964 Sodium Bile acid symporter family; Region: SBF; cl17470 1278073011965 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1278073011966 active site 1278073011967 homotetramer interface [polypeptide binding]; other site 1278073011968 homodimer interface [polypeptide binding]; other site 1278073011969 aspartate 4-decarboxylase; Region: asp_4_decarbox; TIGR03801 1278073011970 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1278073011971 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1278073011972 homodimer interface [polypeptide binding]; other site 1278073011973 catalytic residue [active] 1278073011974 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1278073011975 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1278073011976 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1278073011977 Ornithine cyclodeaminase/mu-crystallin family; Region: OCD_Mu_crystall; pfam02423 1278073011978 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1278073011979 HTH-like domain; Region: HTH_21; pfam13276 1278073011980 Integrase core domain; Region: rve; pfam00665 1278073011981 Helix-turn-helix domain; Region: HTH_28; pfam13518 1278073011982 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1278073011983 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1278073011984 Terminase small subunit; Region: Terminase_2; cl01513 1278073011985 Helix-turn-helix domain; Region: HTH_28; pfam13518 1278073011986 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1278073011987 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1278073011988 NAD(P) binding site [chemical binding]; other site 1278073011989 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 1278073011990 putative active site [active] 1278073011991 putative catalytic site [active] 1278073011992 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 1278073011993 hypothetical protein; Provisional; Region: PRK07505 1278073011994 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 1278073011995 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1278073011996 catalytic residue [active] 1278073011997 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073011998 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073011999 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1278073012000 acyl-activating enzyme (AAE) consensus motif; other site 1278073012001 AMP binding site [chemical binding]; other site 1278073012002 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073012003 Condensation domain; Region: Condensation; pfam00668 1278073012004 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073012005 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073012006 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 1278073012007 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1278073012008 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1278073012009 ligand binding site [chemical binding]; other site 1278073012010 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1278073012011 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1278073012012 ligand binding site [chemical binding]; other site 1278073012013 flexible hinge region; other site 1278073012014 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1278073012015 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1278073012016 ligand binding site [chemical binding]; other site 1278073012017 flexible hinge region; other site 1278073012018 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1278073012019 putative switch regulator; other site 1278073012020 non-specific DNA interactions [nucleotide binding]; other site 1278073012021 DNA binding site [nucleotide binding] 1278073012022 sequence specific DNA binding site [nucleotide binding]; other site 1278073012023 putative cAMP binding site [chemical binding]; other site 1278073012024 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073012025 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316 1278073012026 NAD(P) binding site [chemical binding]; other site 1278073012027 active site 1278073012028 isochorismate synthase DhbC; Validated; Region: PRK06923 1278073012029 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1278073012030 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 1278073012031 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1278073012032 acyl-activating enzyme (AAE) consensus motif; other site 1278073012033 active site 1278073012034 AMP binding site [chemical binding]; other site 1278073012035 substrate binding site [chemical binding]; other site 1278073012036 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1278073012037 Isochorismatase family; Region: Isochorismatase; pfam00857 1278073012038 catalytic triad [active] 1278073012039 conserved cis-peptide bond; other site 1278073012040 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1278073012041 Condensation domain; Region: Condensation; pfam00668 1278073012042 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1278073012043 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1278073012044 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073012045 acyl-activating enzyme (AAE) consensus motif; other site 1278073012046 AMP binding site [chemical binding]; other site 1278073012047 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073012048 thioester reductase domain; Region: Thioester-redct; TIGR01746 1278073012049 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1278073012050 putative NAD(P) binding site [chemical binding]; other site 1278073012051 active site 1278073012052 putative substrate binding site [chemical binding]; other site 1278073012053 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 1278073012054 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1278073012055 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1278073012056 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1278073012057 N-terminal plug; other site 1278073012058 ligand-binding site [chemical binding]; other site 1278073012059 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1278073012060 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1278073012061 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1278073012062 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1278073012063 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1278073012064 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1278073012065 putative substrate translocation pore; other site 1278073012066 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 1278073012067 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1278073012068 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1278073012069 catalytic residue [active] 1278073012070 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1278073012071 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1278073012072 FAD binding pocket [chemical binding]; other site 1278073012073 FAD binding motif [chemical binding]; other site 1278073012074 phosphate binding motif [ion binding]; other site 1278073012075 NAD binding pocket [chemical binding]; other site 1278073012076 Condensation domain; Region: Condensation; pfam00668 1278073012077 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073012078 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073012079 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 1278073012080 acyl-activating enzyme (AAE) consensus motif; other site 1278073012081 AMP binding site [chemical binding]; other site 1278073012082 thioester reductase domain; Region: Thioester-redct; TIGR01746 1278073012083 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1278073012084 putative NAD(P) binding site [chemical binding]; other site 1278073012085 active site 1278073012086 putative substrate binding site [chemical binding]; other site 1278073012087 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1278073012088 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073012089 active site 1278073012090 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1278073012091 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1278073012092 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073012093 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1278073012094 NAD(P) binding site [chemical binding]; other site 1278073012095 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1278073012096 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1278073012097 putative NADP binding site [chemical binding]; other site 1278073012098 active site 1278073012099 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1278073012100 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1278073012101 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073012102 active site 1278073012103 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1278073012104 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1278073012105 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1278073012106 KR domain; Region: KR; pfam08659 1278073012107 putative NADP binding site [chemical binding]; other site 1278073012108 active site 1278073012109 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1278073012110 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073012111 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1278073012112 active site 1278073012113 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1278073012114 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1278073012115 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1278073012116 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1278073012117 putative NADP binding site [chemical binding]; other site 1278073012118 active site 1278073012119 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1278073012120 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073012121 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1278073012122 active site 1278073012123 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1278073012124 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1278073012125 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1278073012126 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1278073012127 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1278073012128 putative NADP binding site [chemical binding]; other site 1278073012129 active site 1278073012130 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1278073012131 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1278073012132 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073012133 active site 1278073012134 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1278073012135 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1278073012136 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1278073012137 KR domain; Region: KR; pfam08659 1278073012138 putative NADP binding site [chemical binding]; other site 1278073012139 active site 1278073012140 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1278073012141 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073012142 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1278073012143 active site 1278073012144 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1278073012145 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1278073012146 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1278073012147 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1278073012148 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1278073012149 putative NADP binding site [chemical binding]; other site 1278073012150 active site 1278073012151 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1278073012152 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1278073012153 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073012154 active site 1278073012155 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1278073012156 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1278073012157 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1278073012158 KR domain; Region: KR; pfam08659 1278073012159 putative NADP binding site [chemical binding]; other site 1278073012160 active site 1278073012161 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1278073012162 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1278073012163 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073012164 active site 1278073012165 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1278073012166 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1278073012167 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073012168 Enoylreductase; Region: PKS_ER; smart00829 1278073012169 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 1278073012170 NAD(P) binding site [chemical binding]; other site 1278073012171 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1278073012172 KR domain; Region: KR; pfam08659 1278073012173 putative NADP binding site [chemical binding]; other site 1278073012174 active site 1278073012175 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1278073012176 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1278073012177 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1278073012178 E3 interaction surface; other site 1278073012179 lipoyl attachment site [posttranslational modification]; other site 1278073012180 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1278073012181 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1278073012182 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1278073012183 alpha subunit interface [polypeptide binding]; other site 1278073012184 TPP binding site [chemical binding]; other site 1278073012185 heterodimer interface [polypeptide binding]; other site 1278073012186 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1278073012187 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1278073012188 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1278073012189 TPP-binding site [chemical binding]; other site 1278073012190 tetramer interface [polypeptide binding]; other site 1278073012191 heterodimer interface [polypeptide binding]; other site 1278073012192 phosphorylation loop region [posttranslational modification] 1278073012193 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1278073012194 Nuclease-related domain; Region: NERD; pfam08378 1278073012195 Part of AAA domain; Region: AAA_19; pfam13245 1278073012196 Family description; Region: UvrD_C_2; pfam13538 1278073012197 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1278073012198 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1278073012199 ATP-binding site [chemical binding]; other site 1278073012200 Part of AAA domain; Region: AAA_19; pfam13245 1278073012201 Family description; Region: UvrD_C_2; pfam13538 1278073012202 Domain of unknown function (DUF4420); Region: DUF4420; pfam14390 1278073012203 Z1 domain; Region: Z1; pfam10593 1278073012204 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 1278073012205 ATP binding site [chemical binding]; other site 1278073012206 Mg2+ binding site [ion binding]; other site 1278073012207 G-X-G motif; other site 1278073012208 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1278073012209 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1278073012210 cofactor binding site; other site 1278073012211 DNA binding site [nucleotide binding] 1278073012212 substrate interaction site [chemical binding]; other site 1278073012213 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1278073012214 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1278073012215 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 1278073012216 additional DNA contacts [nucleotide binding]; other site 1278073012217 mismatch recognition site; other site 1278073012218 active site 1278073012219 zinc binding site [ion binding]; other site 1278073012220 DNA intercalation site [nucleotide binding]; other site 1278073012221 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1278073012222 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1278073012223 Predicted membrane protein (DUF2070); Region: DUF2070; pfam09843 1278073012224 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1278073012225 acyl-CoA synthetase; Validated; Region: PRK05850 1278073012226 acyl-activating enzyme (AAE) consensus motif; other site 1278073012227 active site 1278073012228 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1278073012229 peptide synthase; Provisional; Region: PRK12316 1278073012230 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073012231 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073012232 acyl-activating enzyme (AAE) consensus motif; other site 1278073012233 AMP binding site [chemical binding]; other site 1278073012234 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073012235 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1278073012236 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073012237 acyl-activating enzyme (AAE) consensus motif; other site 1278073012238 AMP binding site [chemical binding]; other site 1278073012239 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073012240 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073012241 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073012242 acyl-activating enzyme (AAE) consensus motif; other site 1278073012243 AMP binding site [chemical binding]; other site 1278073012244 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073012245 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1278073012246 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1278073012247 acyl-activating enzyme (AAE) consensus motif; other site 1278073012248 AMP binding site [chemical binding]; other site 1278073012249 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073012250 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1278073012251 substrate binding pocket [chemical binding]; other site 1278073012252 active site 1278073012253 iron coordination sites [ion binding]; other site 1278073012254 Cytochrome P450; Region: p450; pfam00067 1278073012255 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1278073012256 Condensation domain; Region: Condensation; pfam00668 1278073012257 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073012258 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073012259 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073012260 acyl-activating enzyme (AAE) consensus motif; other site 1278073012261 AMP binding site [chemical binding]; other site 1278073012262 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073012263 Condensation domain; Region: Condensation; pfam00668 1278073012264 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073012265 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1278073012266 Condensation domain; Region: Condensation; pfam00668 1278073012267 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073012268 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1278073012269 acyl-activating enzyme (AAE) consensus motif; other site 1278073012270 AMP binding site [chemical binding]; other site 1278073012271 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073012272 Condensation domain; Region: Condensation; pfam00668 1278073012273 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073012274 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073012275 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073012276 acyl-activating enzyme (AAE) consensus motif; other site 1278073012277 AMP binding site [chemical binding]; other site 1278073012278 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073012279 Condensation domain; Region: Condensation; pfam00668 1278073012280 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073012281 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073012282 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073012283 acyl-activating enzyme (AAE) consensus motif; other site 1278073012284 AMP binding site [chemical binding]; other site 1278073012285 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073012286 Condensation domain; Region: Condensation; pfam00668 1278073012287 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073012288 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073012289 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1278073012290 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1278073012291 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 1278073012292 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1278073012293 active site 1278073012294 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1278073012295 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1278073012296 active site 1278073012297 TDP-binding site; other site 1278073012298 acceptor substrate-binding pocket; other site 1278073012299 homodimer interface [polypeptide binding]; other site 1278073012300 cyclic peptide transporter; Region: cyc_pep_trnsptr; TIGR01194 1278073012301 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073012302 Walker A/P-loop; other site 1278073012303 ATP binding site [chemical binding]; other site 1278073012304 ABC transporter signature motif; other site 1278073012305 Walker B; other site 1278073012306 D-loop; other site 1278073012307 H-loop/switch region; other site 1278073012308 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 1278073012309 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1278073012310 ATP binding site [chemical binding]; other site 1278073012311 putative Mg++ binding site [ion binding]; other site 1278073012312 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1278073012313 ATP-binding site [chemical binding]; other site 1278073012314 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1278073012315 IHF dimer interface [polypeptide binding]; other site 1278073012316 IHF - DNA interface [nucleotide binding]; other site 1278073012317 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1278073012318 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1278073012319 putative tRNA-binding site [nucleotide binding]; other site 1278073012320 B3/4 domain; Region: B3_4; pfam03483 1278073012321 tRNA synthetase B5 domain; Region: B5; smart00874 1278073012322 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1278073012323 dimer interface [polypeptide binding]; other site 1278073012324 motif 1; other site 1278073012325 motif 3; other site 1278073012326 motif 2; other site 1278073012327 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1278073012328 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1278073012329 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1278073012330 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1278073012331 dimer interface [polypeptide binding]; other site 1278073012332 motif 1; other site 1278073012333 active site 1278073012334 motif 2; other site 1278073012335 motif 3; other site 1278073012336 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1278073012337 23S rRNA binding site [nucleotide binding]; other site 1278073012338 L21 binding site [polypeptide binding]; other site 1278073012339 L13 binding site [polypeptide binding]; other site 1278073012340 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1278073012341 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1278073012342 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1278073012343 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1278073012344 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1278073012345 active site 1278073012346 dimer interface [polypeptide binding]; other site 1278073012347 motif 1; other site 1278073012348 motif 2; other site 1278073012349 motif 3; other site 1278073012350 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1278073012351 anticodon binding site; other site 1278073012352 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 1278073012353 Fe-S cluster binding site [ion binding]; other site 1278073012354 DNA binding site [nucleotide binding] 1278073012355 active site 1278073012356 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1278073012357 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1278073012358 PEGA domain; Region: PEGA; pfam08308 1278073012359 LPP20 lipoprotein; Region: LPP20; pfam02169 1278073012360 PilZ domain; Region: PilZ; pfam07238 1278073012361 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1278073012362 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1278073012363 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1278073012364 Methyltransferase domain; Region: Methyltransf_24; pfam13578 1278073012365 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1278073012366 Zn binding site [ion binding]; other site 1278073012367 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1278073012368 DNA-binding site [nucleotide binding]; DNA binding site 1278073012369 RNA-binding motif; other site 1278073012370 Peptidase family M2 Angiotensin converting enzyme (ACE); Region: M2_ACE; cd06461 1278073012371 active site 1278073012372 Zn binding site [ion binding]; other site 1278073012373 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 1278073012374 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 1278073012375 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 1278073012376 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1278073012377 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1278073012378 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 1278073012379 Baseplate J-like protein; Region: Baseplate_J; cl01294 1278073012380 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 1278073012381 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 1278073012382 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1278073012383 putative transporter; Provisional; Region: PRK10504 1278073012384 putative substrate translocation pore; other site 1278073012385 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1278073012386 Pirin; Region: Pirin; pfam02678 1278073012387 Pirin-related protein [General function prediction only]; Region: COG1741 1278073012388 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1278073012389 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 1278073012390 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1278073012391 dimer interface [polypeptide binding]; other site 1278073012392 substrate binding site [chemical binding]; other site 1278073012393 von Willebrand factor; Region: vWF_A; pfam12450 1278073012394 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1278073012395 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 1278073012396 metal ion-dependent adhesion site (MIDAS); other site 1278073012397 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 1278073012398 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1278073012399 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1278073012400 active site residue [active] 1278073012401 ATPase involved in DNA repair; Region: DUF3686; pfam12458 1278073012402 AAA domain; Region: AAA_22; pfam13401 1278073012403 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073012404 Walker A motif; other site 1278073012405 ATP binding site [chemical binding]; other site 1278073012406 Walker B motif; other site 1278073012407 arginine finger; other site 1278073012408 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1278073012409 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1278073012410 O-methyltransferase; Region: Methyltransf_2; pfam00891 1278073012411 Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; cl17879 1278073012412 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1278073012413 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1278073012414 active site 1278073012415 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 1278073012416 amidase; Provisional; Region: PRK08137 1278073012417 Amidase; Region: Amidase; cl11426 1278073012418 putative cation:proton antiport protein; Provisional; Region: PRK10669 1278073012419 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1278073012420 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1278073012421 TrkA-N domain; Region: TrkA_N; pfam02254 1278073012422 TrkA-C domain; Region: TrkA_C; pfam02080 1278073012423 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 1278073012424 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1278073012425 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1278073012426 PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818 1278073012427 PA/protease or protease-like domain interface [polypeptide binding]; other site 1278073012428 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 1278073012429 Zn binding site [ion binding]; other site 1278073012430 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 1278073012431 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1278073012432 30S ribosomal protein S1; Provisional; Region: rpsA; PRK13806 1278073012433 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1278073012434 RNA binding site [nucleotide binding]; other site 1278073012435 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1278073012436 RNA binding site [nucleotide binding]; other site 1278073012437 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1278073012438 RNA binding site [nucleotide binding]; other site 1278073012439 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1278073012440 RNA binding site [nucleotide binding]; other site 1278073012441 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1278073012442 RNA binding site [nucleotide binding]; other site 1278073012443 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 1278073012444 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1278073012445 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1278073012446 dinuclear metal binding motif [ion binding]; other site 1278073012447 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 1278073012448 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1278073012449 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073012450 active site 1278073012451 phosphorylation site [posttranslational modification] 1278073012452 intermolecular recognition site; other site 1278073012453 dimerization interface [polypeptide binding]; other site 1278073012454 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073012455 Walker A motif; other site 1278073012456 ATP binding site [chemical binding]; other site 1278073012457 Walker B motif; other site 1278073012458 arginine finger; other site 1278073012459 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1278073012460 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1278073012461 Peptidase family M23; Region: Peptidase_M23; pfam01551 1278073012462 Predicted methyltransferases [General function prediction only]; Region: COG0313 1278073012463 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1278073012464 putative SAM binding site [chemical binding]; other site 1278073012465 putative homodimer interface [polypeptide binding]; other site 1278073012466 hypothetical protein; Reviewed; Region: PRK12497 1278073012467 AAA domain; Region: AAA_27; pfam13514 1278073012468 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1278073012469 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1278073012470 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1278073012471 RimM N-terminal domain; Region: RimM; pfam01782 1278073012472 PRC-barrel domain; Region: PRC; pfam05239 1278073012473 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1278073012474 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1278073012475 G-X-X-G motif; other site 1278073012476 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 1278073012477 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 1278073012478 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1278073012479 FeS/SAM binding site; other site 1278073012480 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1278073012481 active site 1278073012482 multimer interface [polypeptide binding]; other site 1278073012483 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1278073012484 CoA binding domain; Region: CoA_binding; pfam02629 1278073012485 CoA-ligase; Region: Ligase_CoA; pfam00549 1278073012486 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1278073012487 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1278073012488 CoA-ligase; Region: Ligase_CoA; pfam00549 1278073012489 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 1278073012490 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1278073012491 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1278073012492 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 1278073012493 L-aspartate oxidase; Provisional; Region: PRK06175 1278073012494 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1278073012495 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1278073012496 malate dehydrogenase; Reviewed; Region: PRK06223 1278073012497 dimer interface [polypeptide binding]; other site 1278073012498 NAD(P) binding site [chemical binding]; other site 1278073012499 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1278073012500 substrate binding site [chemical binding]; other site 1278073012501 isocitrate dehydrogenase; Validated; Region: PRK07362 1278073012502 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1278073012503 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073012504 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1278073012505 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1278073012506 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 1278073012507 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 1278073012508 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1278073012509 acyl-activating enzyme (AAE) consensus motif; other site 1278073012510 putative AMP binding site [chemical binding]; other site 1278073012511 putative active site [active] 1278073012512 putative CoA binding site [chemical binding]; other site 1278073012513 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1278073012514 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1278073012515 metal binding site [ion binding]; metal-binding site 1278073012516 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1278073012517 UbiA prenyltransferase family; Region: UbiA; pfam01040 1278073012518 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 1278073012519 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1278073012520 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1278073012521 dimer interface [polypeptide binding]; other site 1278073012522 tetramer interface [polypeptide binding]; other site 1278073012523 PYR/PP interface [polypeptide binding]; other site 1278073012524 TPP binding site [chemical binding]; other site 1278073012525 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1278073012526 TPP-binding site; other site 1278073012527 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 1278073012528 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1278073012529 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 1278073012530 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 1278073012531 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1278073012532 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073012533 S-adenosylmethionine binding site [chemical binding]; other site 1278073012534 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1278073012535 active site 1278073012536 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 1278073012537 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1278073012538 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1278073012539 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1278073012540 Tetramer interface [polypeptide binding]; other site 1278073012541 active site 1278073012542 FMN-binding site [chemical binding]; other site 1278073012543 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1278073012544 active site 1278073012545 NAD binding site [chemical binding]; other site 1278073012546 metal binding site [ion binding]; metal-binding site 1278073012547 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 1278073012548 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 1278073012549 putative active site [active] 1278073012550 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1278073012551 Citrate synthase; Region: Citrate_synt; pfam00285 1278073012552 oxalacetate binding site [chemical binding]; other site 1278073012553 citrylCoA binding site [chemical binding]; other site 1278073012554 coenzyme A binding site [chemical binding]; other site 1278073012555 catalytic triad [active] 1278073012556 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1278073012557 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1278073012558 acyl-activating enzyme (AAE) consensus motif; other site 1278073012559 putative AMP binding site [chemical binding]; other site 1278073012560 putative active site [active] 1278073012561 putative CoA binding site [chemical binding]; other site 1278073012562 Bifunctional nuclease; Region: DNase-RNase; cl00553 1278073012563 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 1278073012564 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1278073012565 domain interfaces; other site 1278073012566 active site 1278073012567 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1278073012568 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1278073012569 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1278073012570 catalytic site [active] 1278073012571 subunit interface [polypeptide binding]; other site 1278073012572 dihydroorotase; Validated; Region: pyrC; PRK09357 1278073012573 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1278073012574 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1278073012575 active site 1278073012576 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1278073012577 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1278073012578 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1278073012579 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1278073012580 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1278073012581 Catalytic site [active] 1278073012582 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1278073012583 GTP-binding protein LepA; Provisional; Region: PRK05433 1278073012584 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1278073012585 G1 box; other site 1278073012586 putative GEF interaction site [polypeptide binding]; other site 1278073012587 GTP/Mg2+ binding site [chemical binding]; other site 1278073012588 Switch I region; other site 1278073012589 G2 box; other site 1278073012590 G3 box; other site 1278073012591 Switch II region; other site 1278073012592 G4 box; other site 1278073012593 G5 box; other site 1278073012594 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1278073012595 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1278073012596 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1278073012597 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1278073012598 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073012599 NAD(P) binding site [chemical binding]; other site 1278073012600 active site 1278073012601 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1278073012602 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 1278073012603 NAD binding site [chemical binding]; other site 1278073012604 putative substrate binding site 2 [chemical binding]; other site 1278073012605 putative substrate binding site 1 [chemical binding]; other site 1278073012606 active site 1278073012607 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 1278073012608 Cupin domain; Region: Cupin_2; cl17218 1278073012609 Sporulation related domain; Region: SPOR; pfam05036 1278073012610 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1278073012611 IHF dimer interface [polypeptide binding]; other site 1278073012612 IHF - DNA interface [nucleotide binding]; other site 1278073012613 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 1278073012614 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1278073012615 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1278073012616 Ligand Binding Site [chemical binding]; other site 1278073012617 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1278073012618 active site 1278073012619 NTP binding site [chemical binding]; other site 1278073012620 metal binding triad [ion binding]; metal-binding site 1278073012621 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1278073012622 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 1278073012623 SurA N-terminal domain; Region: SurA_N_3; cl07813 1278073012624 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1278073012625 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1278073012626 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1278073012627 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1278073012628 homodimer interface [polypeptide binding]; other site 1278073012629 catalytic residue [active] 1278073012630 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1278073012631 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1278073012632 Predicted membrane protein (DUF2070); Region: DUF2070; pfam09843 1278073012633 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1278073012634 ligand-binding site [chemical binding]; other site 1278073012635 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 1278073012636 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1278073012637 CysD dimerization site [polypeptide binding]; other site 1278073012638 G1 box; other site 1278073012639 putative GEF interaction site [polypeptide binding]; other site 1278073012640 GTP/Mg2+ binding site [chemical binding]; other site 1278073012641 Switch I region; other site 1278073012642 G2 box; other site 1278073012643 G3 box; other site 1278073012644 Switch II region; other site 1278073012645 G4 box; other site 1278073012646 G5 box; other site 1278073012647 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1278073012648 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1278073012649 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1278073012650 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1278073012651 Active Sites [active] 1278073012652 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1278073012653 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1278073012654 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 1278073012655 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1278073012656 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1278073012657 DXD motif; other site 1278073012658 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1278073012659 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1278073012660 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1278073012661 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1278073012662 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1278073012663 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1278073012664 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1278073012665 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1278073012666 iron-sulfur cluster [ion binding]; other site 1278073012667 [2Fe-2S] cluster binding site [ion binding]; other site 1278073012668 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1278073012669 SCP-2 sterol transfer family; Region: SCP2; cl01225 1278073012670 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1278073012671 MreB/Mbl protein; Region: MreB_Mbl; pfam06723 1278073012672 nucleotide binding site [chemical binding]; other site 1278073012673 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1278073012674 Part of AAA domain; Region: AAA_19; pfam13245 1278073012675 Family description; Region: UvrD_C_2; pfam13538 1278073012676 HEAT repeats; Region: HEAT_2; pfam13646 1278073012677 CHAP domain; Region: CHAP; cl17642 1278073012678 CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439 1278073012679 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1278073012680 DXD motif; other site 1278073012681 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 1278073012682 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 1278073012683 linker region; other site 1278073012684 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1278073012685 aspartate kinase; Reviewed; Region: PRK06635 1278073012686 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 1278073012687 putative catalytic residues [active] 1278073012688 putative nucleotide binding site [chemical binding]; other site 1278073012689 putative aspartate binding site [chemical binding]; other site 1278073012690 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1278073012691 putative allosteric regulatory site; other site 1278073012692 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1278073012693 putative allosteric regulatory residue; other site 1278073012694 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1278073012695 active sites [active] 1278073012696 tetramer interface [polypeptide binding]; other site 1278073012697 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 1278073012698 Pirin-related protein [General function prediction only]; Region: COG1741 1278073012699 Pirin; Region: Pirin; pfam02678 1278073012700 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1278073012701 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1278073012702 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1278073012703 Cytochrome c; Region: Cytochrom_C; pfam00034 1278073012704 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1278073012705 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1278073012706 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073012707 TPR motif; other site 1278073012708 binding surface 1278073012709 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073012710 binding surface 1278073012711 TPR motif; other site 1278073012712 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 1278073012713 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1278073012714 putative MPT binding site; other site 1278073012715 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1278073012716 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1278073012717 TMP-binding site; other site 1278073012718 ATP-binding site [chemical binding]; other site 1278073012719 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1278073012720 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1278073012721 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 1278073012722 dimerization interface [polypeptide binding]; other site 1278073012723 active site 1278073012724 threonine synthase; Validated; Region: PRK06260 1278073012725 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1278073012726 homodimer interface [polypeptide binding]; other site 1278073012727 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1278073012728 catalytic residue [active] 1278073012729 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 1278073012730 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073012731 S-adenosylmethionine binding site [chemical binding]; other site 1278073012732 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1278073012733 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1278073012734 ssDNA binding site; other site 1278073012735 generic binding surface II; other site 1278073012736 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1278073012737 ATP binding site [chemical binding]; other site 1278073012738 putative Mg++ binding site [ion binding]; other site 1278073012739 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1278073012740 nucleotide binding region [chemical binding]; other site 1278073012741 ATP-binding site [chemical binding]; other site 1278073012742 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1278073012743 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1278073012744 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1278073012745 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1278073012746 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1278073012747 phosphopeptide binding site; other site 1278073012748 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1278073012749 DNA binding site [nucleotide binding] 1278073012750 active site 1278073012751 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1278073012752 TIGR04222 domain; Region: near_uncomplex 1278073012753 hypothetical protein; Provisional; Region: PRK05409 1278073012754 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 1278073012755 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 1278073012756 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 1278073012757 conserved hypothetical protein; Region: TIGR02231 1278073012758 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 1278073012759 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 1278073012760 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1278073012761 substrate binding pocket [chemical binding]; other site 1278073012762 membrane-bound complex binding site; other site 1278073012763 hinge residues; other site 1278073012764 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1278073012765 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1278073012766 substrate binding pocket [chemical binding]; other site 1278073012767 membrane-bound complex binding site; other site 1278073012768 hinge residues; other site 1278073012769 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1278073012770 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1278073012771 catalytic residue [active] 1278073012772 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 1278073012773 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1278073012774 active site 1278073012775 catalytic site [active] 1278073012776 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432 1278073012777 ligand binding surface [chemical binding]; other site 1278073012778 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432 1278073012779 ligand binding surface [chemical binding]; other site 1278073012780 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432 1278073012781 ligand binding surface [chemical binding]; other site 1278073012782 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432 1278073012783 ligand binding surface [chemical binding]; other site 1278073012784 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1278073012785 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1278073012786 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1278073012787 active site 1278073012788 catalytic residues [active] 1278073012789 metal binding site [ion binding]; metal-binding site 1278073012790 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1278073012791 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1278073012792 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1278073012793 putative di-iron ligands [ion binding]; other site 1278073012794 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1278073012795 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1278073012796 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1278073012797 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1278073012798 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1278073012799 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1278073012800 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1278073012801 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1278073012802 IMP binding site; other site 1278073012803 dimer interface [polypeptide binding]; other site 1278073012804 interdomain contacts; other site 1278073012805 partial ornithine binding site; other site 1278073012806 aspartate aminotransferase; Provisional; Region: PRK05764 1278073012807 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1278073012808 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1278073012809 homodimer interface [polypeptide binding]; other site 1278073012810 catalytic residue [active] 1278073012811 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1278073012812 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1278073012813 active site 1278073012814 (T/H)XGH motif; other site 1278073012815 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1278073012816 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073012817 S-adenosylmethionine binding site [chemical binding]; other site 1278073012818 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1278073012819 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1278073012820 Sensory domain found in PocR; Region: PocR; pfam10114 1278073012821 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1278073012822 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073012823 Walker A motif; other site 1278073012824 ATP binding site [chemical binding]; other site 1278073012825 Walker B motif; other site 1278073012826 arginine finger; other site 1278073012827 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1278073012828 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1278073012829 TAP-like protein; Region: Abhydrolase_4; pfam08386 1278073012830 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1278073012831 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1278073012832 G1 box; other site 1278073012833 putative GEF interaction site [polypeptide binding]; other site 1278073012834 GTP/Mg2+ binding site [chemical binding]; other site 1278073012835 Switch I region; other site 1278073012836 G2 box; other site 1278073012837 G3 box; other site 1278073012838 Switch II region; other site 1278073012839 G4 box; other site 1278073012840 G5 box; other site 1278073012841 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1278073012842 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1278073012843 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1278073012844 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1278073012845 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1278073012846 classical (c) SDRs; Region: SDR_c; cd05233 1278073012847 NAD(P) binding site [chemical binding]; other site 1278073012848 active site 1278073012849 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 1278073012850 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1278073012851 phosphopeptide binding site; other site 1278073012852 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1278073012853 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1278073012854 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073012855 binding surface 1278073012856 TPR motif; other site 1278073012857 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1278073012858 TPR repeat; Region: TPR_11; pfam13414 1278073012859 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073012860 binding surface 1278073012861 TPR motif; other site 1278073012862 TPR repeat; Region: TPR_11; pfam13414 1278073012863 TPR repeat; Region: TPR_11; pfam13414 1278073012864 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 1278073012865 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073012866 TPR motif; other site 1278073012867 binding surface 1278073012868 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 1278073012869 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 1278073012870 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951 1278073012871 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1278073012872 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1278073012873 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 1278073012874 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1278073012875 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1278073012876 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1278073012877 catalytic residue [active] 1278073012878 Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604 1278073012879 MoxR-like ATPases [General function prediction only]; Region: COG0714 1278073012880 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073012881 Walker A motif; other site 1278073012882 ATP binding site [chemical binding]; other site 1278073012883 Walker B motif; other site 1278073012884 arginine finger; other site 1278073012885 Protein of unknown function DUF58; Region: DUF58; pfam01882 1278073012886 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 1278073012887 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1278073012888 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1278073012889 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1278073012890 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1278073012891 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1278073012892 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073012893 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1278073012894 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1278073012895 DNA binding residues [nucleotide binding] 1278073012896 OPT oligopeptide transporter protein; Region: OPT; cl14607 1278073012897 OPT oligopeptide transporter protein; Region: OPT; cl14607 1278073012898 HEAT repeats; Region: HEAT_2; pfam13646 1278073012899 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1278073012900 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 1278073012901 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1278073012902 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1278073012903 RNA binding surface [nucleotide binding]; other site 1278073012904 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1278073012905 active site 1278073012906 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1278073012907 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 1278073012908 HSP70 interaction site [polypeptide binding]; other site 1278073012909 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1278073012910 non-specific DNA binding site [nucleotide binding]; other site 1278073012911 salt bridge; other site 1278073012912 sequence-specific DNA binding site [nucleotide binding]; other site 1278073012913 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1278073012914 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1278073012915 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1278073012916 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1278073012917 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1278073012918 active site 1278073012919 seryl-tRNA(sec) selenium transferase; Region: selA; TIGR00474 1278073012920 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 1278073012921 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1278073012922 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1278073012923 YceG-like family; Region: YceG; pfam02618 1278073012924 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1278073012925 dimerization interface [polypeptide binding]; other site 1278073012926 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1278073012927 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1278073012928 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1278073012929 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1278073012930 putative dimer interface [polypeptide binding]; other site 1278073012931 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1278073012932 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1278073012933 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1278073012934 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1278073012935 catalytic residue [active] 1278073012936 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1278073012937 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1278073012938 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1278073012939 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073012940 phosphorylation site [posttranslational modification] 1278073012941 dimer interface [polypeptide binding]; other site 1278073012942 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073012943 ATP binding site [chemical binding]; other site 1278073012944 Mg2+ binding site [ion binding]; other site 1278073012945 G-X-G motif; other site 1278073012946 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1278073012947 Interdomain contacts; other site 1278073012948 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1278073012949 Interdomain contacts; other site 1278073012950 Cytokine receptor motif; other site 1278073012951 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1278073012952 Interdomain contacts; other site 1278073012953 Cytokine receptor motif; other site 1278073012954 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1278073012955 Interdomain contacts; other site 1278073012956 Cytokine receptor motif; other site 1278073012957 Family description; Region: VCBS; pfam13517 1278073012958 Family description; Region: VCBS; pfam13517 1278073012959 Family description; Region: VCBS; pfam13517 1278073012960 Family description; Region: VCBS; pfam13517 1278073012961 Family description; Region: VCBS; pfam13517 1278073012962 Family description; Region: VCBS; pfam13517 1278073012963 Family description; Region: VCBS; pfam13517 1278073012964 Family description; Region: VCBS; pfam13517 1278073012965 Family description; Region: VCBS; pfam13517 1278073012966 Family description; Region: VCBS; pfam13517 1278073012967 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1278073012968 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1278073012969 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1278073012970 ABC transporter; Region: ABC_tran_2; pfam12848 1278073012971 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1278073012972 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1278073012973 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073012974 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073012975 active site 1278073012976 ATP binding site [chemical binding]; other site 1278073012977 substrate binding site [chemical binding]; other site 1278073012978 activation loop (A-loop); other site 1278073012979 NAD-dependent deacetylase; Provisional; Region: PRK00481 1278073012980 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1278073012981 NAD+ binding site [chemical binding]; other site 1278073012982 substrate binding site [chemical binding]; other site 1278073012983 Zn binding site [ion binding]; other site 1278073012984 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1278073012985 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 1278073012986 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1278073012987 EamA-like transporter family; Region: EamA; pfam00892 1278073012988 EamA-like transporter family; Region: EamA; pfam00892 1278073012989 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1278073012990 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1278073012991 phosphopeptide binding site; other site 1278073012992 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1278073012993 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073012994 Walker A motif; other site 1278073012995 ATP binding site [chemical binding]; other site 1278073012996 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1278073012997 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1278073012998 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1278073012999 Substrate-binding site [chemical binding]; other site 1278073013000 Substrate specificity [chemical binding]; other site 1278073013001 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1278073013002 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1278073013003 putative acyl-acceptor binding pocket; other site 1278073013004 TPR repeat; Region: TPR_11; pfam13414 1278073013005 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073013006 TPR motif; other site 1278073013007 binding surface 1278073013008 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073013009 TPR motif; other site 1278073013010 TPR repeat; Region: TPR_11; pfam13414 1278073013011 binding surface 1278073013012 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073013013 binding surface 1278073013014 TPR motif; other site 1278073013015 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1278073013016 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1278073013017 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1278073013018 alphaNTD homodimer interface [polypeptide binding]; other site 1278073013019 alphaNTD - beta interaction site [polypeptide binding]; other site 1278073013020 alphaNTD - beta' interaction site [polypeptide binding]; other site 1278073013021 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1278073013022 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1278073013023 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1278073013024 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1278073013025 RNA binding surface [nucleotide binding]; other site 1278073013026 30S ribosomal protein S11; Validated; Region: PRK05309 1278073013027 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1278073013028 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1278073013029 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 1278073013030 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1278073013031 rRNA binding site [nucleotide binding]; other site 1278073013032 predicted 30S ribosome binding site; other site 1278073013033 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1278073013034 active site 1278073013035 adenylate kinase; Reviewed; Region: adk; PRK00279 1278073013036 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1278073013037 AMP-binding site [chemical binding]; other site 1278073013038 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1278073013039 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1278073013040 SecY translocase; Region: SecY; pfam00344 1278073013041 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1278073013042 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1278073013043 23S rRNA binding site [nucleotide binding]; other site 1278073013044 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1278073013045 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1278073013046 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1278073013047 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1278073013048 23S rRNA interface [nucleotide binding]; other site 1278073013049 5S rRNA interface [nucleotide binding]; other site 1278073013050 L27 interface [polypeptide binding]; other site 1278073013051 L5 interface [polypeptide binding]; other site 1278073013052 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1278073013053 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1278073013054 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1278073013055 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1278073013056 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1278073013057 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1278073013058 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1278073013059 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1278073013060 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1278073013061 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1278073013062 RNA binding site [nucleotide binding]; other site 1278073013063 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1278073013064 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1278073013065 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1278073013066 23S rRNA interface [nucleotide binding]; other site 1278073013067 putative translocon interaction site; other site 1278073013068 signal recognition particle (SRP54) interaction site; other site 1278073013069 L23 interface [polypeptide binding]; other site 1278073013070 trigger factor interaction site; other site 1278073013071 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1278073013072 23S rRNA interface [nucleotide binding]; other site 1278073013073 5S rRNA interface [nucleotide binding]; other site 1278073013074 putative antibiotic binding site [chemical binding]; other site 1278073013075 L25 interface [polypeptide binding]; other site 1278073013076 L27 interface [polypeptide binding]; other site 1278073013077 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1278073013078 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1278073013079 G-X-X-G motif; other site 1278073013080 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1278073013081 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1278073013082 putative translocon binding site; other site 1278073013083 protein-rRNA interface [nucleotide binding]; other site 1278073013084 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1278073013085 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1278073013086 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1278073013087 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1278073013088 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1278073013089 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1278073013090 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1278073013091 elongation factor Tu; Reviewed; Region: PRK00049 1278073013092 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1278073013093 G1 box; other site 1278073013094 GEF interaction site [polypeptide binding]; other site 1278073013095 GTP/Mg2+ binding site [chemical binding]; other site 1278073013096 Switch I region; other site 1278073013097 G2 box; other site 1278073013098 G3 box; other site 1278073013099 Switch II region; other site 1278073013100 G4 box; other site 1278073013101 G5 box; other site 1278073013102 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1278073013103 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1278073013104 Antibiotic Binding Site [chemical binding]; other site 1278073013105 elongation factor G; Reviewed; Region: PRK00007 1278073013106 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1278073013107 G1 box; other site 1278073013108 putative GEF interaction site [polypeptide binding]; other site 1278073013109 GTP/Mg2+ binding site [chemical binding]; other site 1278073013110 Switch I region; other site 1278073013111 G2 box; other site 1278073013112 G3 box; other site 1278073013113 Switch II region; other site 1278073013114 G4 box; other site 1278073013115 G5 box; other site 1278073013116 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1278073013117 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1278073013118 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1278073013119 30S ribosomal protein S7; Validated; Region: PRK05302 1278073013120 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1278073013121 S17 interaction site [polypeptide binding]; other site 1278073013122 S8 interaction site; other site 1278073013123 16S rRNA interaction site [nucleotide binding]; other site 1278073013124 streptomycin interaction site [chemical binding]; other site 1278073013125 23S rRNA interaction site [nucleotide binding]; other site 1278073013126 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1278073013127 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1278073013128 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1278073013129 Coenzyme A binding pocket [chemical binding]; other site 1278073013130 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 1278073013131 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1278073013132 HSP70 interaction site [polypeptide binding]; other site 1278073013133 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1278073013134 substrate binding site [polypeptide binding]; other site 1278073013135 dimer interface [polypeptide binding]; other site 1278073013136 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073013137 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073013138 dimer interface [polypeptide binding]; other site 1278073013139 phosphorylation site [posttranslational modification] 1278073013140 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073013141 ATP binding site [chemical binding]; other site 1278073013142 Mg2+ binding site [ion binding]; other site 1278073013143 G-X-G motif; other site 1278073013144 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073013145 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073013146 active site 1278073013147 phosphorylation site [posttranslational modification] 1278073013148 intermolecular recognition site; other site 1278073013149 dimerization interface [polypeptide binding]; other site 1278073013150 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 1278073013151 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1278073013152 active site 1278073013153 HIGH motif; other site 1278073013154 KMSK motif region; other site 1278073013155 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1278073013156 tRNA binding surface [nucleotide binding]; other site 1278073013157 anticodon binding site; other site 1278073013158 glycerol-3-phosphate acyltransferase; Reviewed; Region: PRK11915 1278073013159 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1278073013160 putative acyl-acceptor binding pocket; other site 1278073013161 Bacterial Ig-like domain; Region: Big_5; pfam13205 1278073013162 c(7)-type cytochrome triheme domain; Region: nanowire_3heme; TIGR04257 1278073013163 CAAX protease self-immunity; Region: Abi; pfam02517 1278073013164 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 1278073013165 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 1278073013166 active site 1278073013167 catalytic triad [active] 1278073013168 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 1278073013169 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 1278073013170 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1278073013171 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1278073013172 putative RNA binding site [nucleotide binding]; other site 1278073013173 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073013174 S-adenosylmethionine binding site [chemical binding]; other site 1278073013175 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 1278073013176 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1278073013177 active site 1278073013178 motif I; other site 1278073013179 motif II; other site 1278073013180 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1278073013181 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1278073013182 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 1278073013183 oligomer interface [polypeptide binding]; other site 1278073013184 metal binding site [ion binding]; metal-binding site 1278073013185 metal binding site [ion binding]; metal-binding site 1278073013186 putative Cl binding site [ion binding]; other site 1278073013187 aspartate ring; other site 1278073013188 basic sphincter; other site 1278073013189 hydrophobic gate; other site 1278073013190 periplasmic entrance; other site 1278073013191 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1278073013192 TAP-like protein; Region: Abhydrolase_4; pfam08386 1278073013193 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 1278073013194 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1278073013195 active site 1278073013196 dimer interface [polypeptide binding]; other site 1278073013197 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073013198 active site 1278073013199 substrate binding site [chemical binding]; other site 1278073013200 ATP binding site [chemical binding]; other site 1278073013201 activation loop (A-loop); other site 1278073013202 Cytochrome c; Region: Cytochrom_C; pfam00034 1278073013203 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1278073013204 thiS-thiF/thiG interaction site; other site 1278073013205 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1278073013206 ThiS interaction site; other site 1278073013207 putative active site [active] 1278073013208 tetramer interface [polypeptide binding]; other site 1278073013209 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1278073013210 thiamine phosphate binding site [chemical binding]; other site 1278073013211 active site 1278073013212 pyrophosphate binding site [ion binding]; other site 1278073013213 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 1278073013214 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 1278073013215 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1278073013216 putative homodimer interface [polypeptide binding]; other site 1278073013217 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1278073013218 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1278073013219 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 1278073013220 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1278073013221 active site 1278073013222 substrate binding site [chemical binding]; other site 1278073013223 trimer interface [polypeptide binding]; other site 1278073013224 CoA binding site [chemical binding]; other site 1278073013225 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 1278073013226 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1278073013227 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1278073013228 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1278073013229 putative active site [active] 1278073013230 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 1278073013231 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073013232 Walker A/P-loop; other site 1278073013233 ATP binding site [chemical binding]; other site 1278073013234 Q-loop/lid; other site 1278073013235 ABC transporter signature motif; other site 1278073013236 Walker B; other site 1278073013237 D-loop; other site 1278073013238 H-loop/switch region; other site 1278073013239 ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CcmB; COG2386 1278073013240 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1278073013241 CcmE; Region: CcmE; pfam03100 1278073013242 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 1278073013243 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1278073013244 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1278073013245 catalytic residues [active] 1278073013246 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1278073013247 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1278073013248 Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862 1278073013249 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 1278073013250 Beta-lactamase; Region: Beta-lactamase; pfam00144 1278073013251 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1278073013252 TPR repeat; Region: TPR_11; pfam13414 1278073013253 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073013254 binding surface 1278073013255 TPR motif; other site 1278073013256 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1278073013257 Beta-lactamase; Region: Beta-lactamase; pfam00144 1278073013258 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073013259 binding surface 1278073013260 TPR repeat; Region: TPR_11; pfam13414 1278073013261 TPR motif; other site 1278073013262 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 1278073013263 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073013264 TPR motif; other site 1278073013265 binding surface 1278073013266 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 1278073013267 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1278073013268 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1278073013269 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1278073013270 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1278073013271 catalytic residue [active] 1278073013272 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 1278073013273 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1278073013274 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1278073013275 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1278073013276 phosphate binding site [ion binding]; other site 1278073013277 putative substrate binding pocket [chemical binding]; other site 1278073013278 dimer interface [polypeptide binding]; other site 1278073013279 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1278073013280 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1278073013281 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 1278073013282 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1278073013283 Chain length determinant protein; Region: Wzz; pfam02706 1278073013284 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 1278073013285 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1278073013286 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 1278073013287 SLBB domain; Region: SLBB; pfam10531 1278073013288 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1278073013289 classical (c) SDRs; Region: SDR_c; cd05233 1278073013290 NAD(P) binding site [chemical binding]; other site 1278073013291 active site 1278073013292 EVE domain; Region: EVE; pfam01878 1278073013293 amino acid permease (GABA permease); Region: 2A0304; TIGR00907 1278073013294 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 1278073013295 dimer interface [polypeptide binding]; other site 1278073013296 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1278073013297 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073013298 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1278073013299 DNA binding residues [nucleotide binding] 1278073013300 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1278073013301 Chorismate mutase type II; Region: CM_2; smart00830 1278073013302 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1278073013303 Prephenate dehydratase; Region: PDT; pfam00800 1278073013304 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1278073013305 putative L-Phe binding site [chemical binding]; other site 1278073013306 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1278073013307 Prephenate dehydratase; Region: PDT; pfam00800 1278073013308 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1278073013309 putative L-Phe binding site [chemical binding]; other site 1278073013310 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroA; COG2876 1278073013311 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 1278073013312 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073013313 binding surface 1278073013314 TPR repeat; Region: TPR_11; pfam13414 1278073013315 TPR motif; other site 1278073013316 Caspase domain; Region: Peptidase_C14; pfam00656 1278073013317 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1278073013318 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 1278073013319 putative NAD(P) binding site [chemical binding]; other site 1278073013320 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1278073013321 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073013322 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073013323 active site 1278073013324 phosphorylation site [posttranslational modification] 1278073013325 intermolecular recognition site; other site 1278073013326 dimerization interface [polypeptide binding]; other site 1278073013327 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073013328 Walker A motif; other site 1278073013329 ATP binding site [chemical binding]; other site 1278073013330 Walker B motif; other site 1278073013331 arginine finger; other site 1278073013332 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1278073013333 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1278073013334 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073013335 active site 1278073013336 phosphorylation site [posttranslational modification] 1278073013337 intermolecular recognition site; other site 1278073013338 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1278073013339 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1278073013340 metal binding site [ion binding]; metal-binding site 1278073013341 active site 1278073013342 I-site; other site 1278073013343 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 1278073013344 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 1278073013345 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1278073013346 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 1278073013347 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1278073013348 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1278073013349 Walker A/P-loop; other site 1278073013350 ATP binding site [chemical binding]; other site 1278073013351 Q-loop/lid; other site 1278073013352 ABC transporter signature motif; other site 1278073013353 Walker B; other site 1278073013354 D-loop; other site 1278073013355 H-loop/switch region; other site 1278073013356 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1278073013357 CPxP motif; other site 1278073013358 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1278073013359 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1278073013360 Thioredoxin; Region: Thioredoxin_4; pfam13462 1278073013361 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1278073013362 Thioredoxin; Region: Thioredoxin_4; pfam13462 1278073013363 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1278073013364 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1278073013365 homotrimer interaction site [polypeptide binding]; other site 1278073013366 putative active site [active] 1278073013367 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1278073013368 HD domain; Region: HD_4; pfam13328 1278073013369 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1278073013370 synthetase active site [active] 1278073013371 NTP binding site [chemical binding]; other site 1278073013372 metal binding site [ion binding]; metal-binding site 1278073013373 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1278073013374 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1278073013375 FHA domain; Region: FHA; pfam00498 1278073013376 phosphopeptide binding site; other site 1278073013377 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1278073013378 phosphopeptide binding site; other site 1278073013379 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1278073013380 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073013381 active site 1278073013382 ATP binding site [chemical binding]; other site 1278073013383 substrate binding site [chemical binding]; other site 1278073013384 activation loop (A-loop); other site 1278073013385 TPR repeat; Region: TPR_11; pfam13414 1278073013386 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1278073013387 Double zinc ribbon; Region: DZR; pfam12773 1278073013388 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1278073013389 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1278073013390 phosphopeptide binding site; other site 1278073013391 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 1278073013392 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1278073013393 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1278073013394 metal ion-dependent adhesion site (MIDAS); other site 1278073013395 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073013396 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1278073013397 Walker A motif; other site 1278073013398 ATP binding site [chemical binding]; other site 1278073013399 Walker B motif; other site 1278073013400 arginine finger; other site 1278073013401 Protein of unknown function, DUF393; Region: DUF393; pfam04134 1278073013402 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1278073013403 hydrophobic ligand binding site; other site 1278073013404 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1278073013405 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1278073013406 nucleotide binding site [chemical binding]; other site 1278073013407 NEF interaction site [polypeptide binding]; other site 1278073013408 SBD interface [polypeptide binding]; other site 1278073013409 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1278073013410 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1278073013411 Protein of unknown function (DUF493); Region: DUF493; pfam04359 1278073013412 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1278073013413 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1278073013414 putative active site [active] 1278073013415 PhoH-like protein; Region: PhoH; pfam02562 1278073013416 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 1278073013417 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1278073013418 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1278073013419 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1278073013420 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1278073013421 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1278073013422 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1278073013423 phosphopeptide binding site; other site 1278073013424 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 1278073013425 Clp amino terminal domain; Region: Clp_N; pfam02861 1278073013426 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073013427 Walker A motif; other site 1278073013428 ATP binding site [chemical binding]; other site 1278073013429 Walker B motif; other site 1278073013430 arginine finger; other site 1278073013431 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073013432 Walker A motif; other site 1278073013433 ATP binding site [chemical binding]; other site 1278073013434 Walker B motif; other site 1278073013435 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1278073013436 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 1278073013437 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 1278073013438 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 1278073013439 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 1278073013440 Protein of unknown function (DUF796); Region: DUF796; cl01226 1278073013441 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 1278073013442 Protein of unknown function (DUF877); Region: DUF877; pfam05943 1278073013443 Protein of unknown function (DUF770); Region: DUF770; pfam05591 1278073013444 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 1278073013445 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 1278073013446 Uncharacterized protein conserved in bacteria (DUF2094); Region: DUF2094; cl01611 1278073013447 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 1278073013448 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1278073013449 G1 box; other site 1278073013450 GTP/Mg2+ binding site [chemical binding]; other site 1278073013451 G2 box; other site 1278073013452 Switch I region; other site 1278073013453 G3 box; other site 1278073013454 Switch II region; other site 1278073013455 G4 box; other site 1278073013456 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 1278073013457 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 1278073013458 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 1278073013459 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 1278073013460 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 1278073013461 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 1278073013462 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1278073013463 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1278073013464 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 1278073013465 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1278073013466 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073013467 active site 1278073013468 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073013469 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1278073013470 active site 1278073013471 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1278073013472 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1278073013473 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073013474 active site 1278073013475 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073013476 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1278073013477 active site 1278073013478 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1278073013479 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1278073013480 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1278073013481 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 1278073013482 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1278073013483 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073013484 polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103 1278073013485 active site 1278073013486 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073013487 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1278073013488 active site 1278073013489 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417 1278073013490 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1278073013491 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1278073013492 putative NADP binding site [chemical binding]; other site 1278073013493 KR domain; Region: KR; pfam08659 1278073013494 active site 1278073013495 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1278073013496 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073013497 active site 1278073013498 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073013499 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1278073013500 active site 1278073013501 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1278073013502 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1278073013503 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1278073013504 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 1278073013505 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1278073013506 Cytochrome P450; Region: p450; cl12078 1278073013507 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1278073013508 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1278073013509 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1278073013510 Cytochrome P450; Region: p450; cl12078 1278073013511 Cupin domain; Region: Cupin_2; cl17218 1278073013512 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 1278073013513 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1278073013514 FeS/SAM binding site; other site 1278073013515 HemN C-terminal domain; Region: HemN_C; pfam06969 1278073013516 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 1278073013517 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1278073013518 FeS/SAM binding site; other site 1278073013519 HemN C-terminal domain; Region: HemN_C; pfam06969 1278073013520 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1278073013521 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073013522 S-adenosylmethionine binding site [chemical binding]; other site 1278073013523 Amidohydrolase; Region: Amidohydro_2; pfam04909 1278073013524 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 1278073013525 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1278073013526 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1278073013527 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1278073013528 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1278073013529 active site 1278073013530 catalytic residues [active] 1278073013531 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1278073013532 Cytochrome P450; Region: p450; cl12078 1278073013533 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1278073013534 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1278073013535 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1278073013536 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1278073013537 FeS/SAM binding site; other site 1278073013538 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1278073013539 Aromatic prenyltransferase Orf2; Region: PTase_Orf2; pfam11468 1278073013540 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1278073013541 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 1278073013542 HEAT repeats; Region: HEAT_2; pfam13646 1278073013543 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1278073013544 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1278073013545 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1278073013546 Cytochrome P450; Region: p450; cl12078 1278073013547 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1278073013548 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 1278073013549 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1278073013550 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 1278073013551 acyl-activating enzyme (AAE) consensus motif; other site 1278073013552 acyl-activating enzyme (AAE) consensus motif; other site 1278073013553 putative AMP binding site [chemical binding]; other site 1278073013554 putative active site [active] 1278073013555 putative CoA binding site [chemical binding]; other site 1278073013556 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1278073013557 DUF35 OB-fold domain; Region: DUF35; pfam01796 1278073013558 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 1278073013559 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 1278073013560 DUF35 OB-fold domain; Region: DUF35; pfam01796 1278073013561 lipid-transfer protein; Provisional; Region: PRK07937 1278073013562 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1278073013563 active site 1278073013564 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 1278073013565 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 1278073013566 active site 1278073013567 acyl-CoA synthetase; Validated; Region: PRK07798 1278073013568 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1278073013569 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_5; cd05924 1278073013570 acyl-activating enzyme (AAE) consensus motif; other site 1278073013571 acyl-activating enzyme (AAE) consensus motif; other site 1278073013572 putative AMP binding site [chemical binding]; other site 1278073013573 putative active site [active] 1278073013574 putative CoA binding site [chemical binding]; other site 1278073013575 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1278073013576 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1278073013577 active site 1278073013578 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1278073013579 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1278073013580 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1278073013581 active site 1278073013582 Nitronate monooxygenase; Region: NMO; pfam03060 1278073013583 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1278073013584 FMN binding site [chemical binding]; other site 1278073013585 substrate binding site [chemical binding]; other site 1278073013586 putative catalytic residue [active] 1278073013587 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1278073013588 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1278073013589 [2Fe-2S] cluster binding site [ion binding]; other site 1278073013590 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK12844 1278073013591 Predicted oxidoreductase [General function prediction only]; Region: COG3573 1278073013592 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1278073013593 classical (c) SDRs; Region: SDR_c; cd05233 1278073013594 NAD(P) binding site [chemical binding]; other site 1278073013595 active site 1278073013596 enoyl-CoA hydratase; Provisional; Region: PRK07799 1278073013597 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1278073013598 substrate binding site [chemical binding]; other site 1278073013599 oxyanion hole (OAH) forming residues; other site 1278073013600 trimer interface [polypeptide binding]; other site 1278073013601 Cytochrome P450; Region: p450; cl12078 1278073013602 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1278073013603 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1278073013604 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 1278073013605 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1278073013606 active site 1278073013607 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1278073013608 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1278073013609 active site 1278073013610 Necrosis inducing protein (NPP1); Region: NPP1; pfam05630 1278073013611 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1278073013612 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 1278073013613 dimer interface [polypeptide binding]; other site 1278073013614 metal binding site [ion binding]; metal-binding site 1278073013615 glutamate dehydrogenase; Region: PLN02477 1278073013616 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1278073013617 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1278073013618 NAD(P) binding site [chemical binding]; other site 1278073013619 PilZ domain; Region: PilZ; pfam07238 1278073013620 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1278073013621 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1278073013622 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1278073013623 protein binding site [polypeptide binding]; other site 1278073013624 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1278073013625 protein binding site [polypeptide binding]; other site 1278073013626 GrpE; Region: GrpE; pfam01025 1278073013627 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1278073013628 dimer interface [polypeptide binding]; other site 1278073013629 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1278073013630 anthranilate synthase component I; Provisional; Region: PRK13572 1278073013631 FtsH Extracellular; Region: FtsH_ext; pfam06480 1278073013632 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1278073013633 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073013634 Walker A motif; other site 1278073013635 ATP binding site [chemical binding]; other site 1278073013636 Walker B motif; other site 1278073013637 arginine finger; other site 1278073013638 Peptidase family M41; Region: Peptidase_M41; pfam01434 1278073013639 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1278073013640 active site 1278073013641 8-oxo-dGMP binding site [chemical binding]; other site 1278073013642 nudix motif; other site 1278073013643 metal binding site [ion binding]; metal-binding site 1278073013644 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1278073013645 non-specific DNA binding site [nucleotide binding]; other site 1278073013646 salt bridge; other site 1278073013647 sequence-specific DNA binding site [nucleotide binding]; other site 1278073013648 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 1278073013649 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1278073013650 Beta-Casp domain; Region: Beta-Casp; smart01027 1278073013651 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1278073013652 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DedD; COG3147 1278073013653 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1278073013654 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1278073013655 putative molybdopterin cofactor binding site [chemical binding]; other site 1278073013656 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1278073013657 putative molybdopterin cofactor binding site; other site 1278073013658 BON domain; Region: BON; pfam04972 1278073013659 urocanate hydratase; Provisional; Region: PRK05414 1278073013660 imidazolonepropionase; Validated; Region: PRK09356 1278073013661 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1278073013662 active site 1278073013663 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 1278073013664 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1278073013665 putative active site [active] 1278073013666 putative dimer interface [polypeptide binding]; other site 1278073013667 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1278073013668 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 1278073013669 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1278073013670 putative substrate binding site [chemical binding]; other site 1278073013671 putative ATP binding site [chemical binding]; other site 1278073013672 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1278073013673 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1278073013674 active site 1278073013675 hydrophilic channel; other site 1278073013676 dimerization interface [polypeptide binding]; other site 1278073013677 catalytic residues [active] 1278073013678 active site lid [active] 1278073013679 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 1278073013680 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1278073013681 active site 1278073013682 substrate binding site [chemical binding]; other site 1278073013683 metal binding site [ion binding]; metal-binding site 1278073013684 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1278073013685 dihydropteroate synthase; Region: DHPS; TIGR01496 1278073013686 substrate binding pocket [chemical binding]; other site 1278073013687 dimer interface [polypeptide binding]; other site 1278073013688 inhibitor binding site; inhibition site 1278073013689 FtsH Extracellular; Region: FtsH_ext; pfam06480 1278073013690 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1278073013691 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1278073013692 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073013693 Walker A motif; other site 1278073013694 ATP binding site [chemical binding]; other site 1278073013695 Walker B motif; other site 1278073013696 arginine finger; other site 1278073013697 Peptidase family M41; Region: Peptidase_M41; pfam01434 1278073013698 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1278073013699 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1278073013700 Ligand Binding Site [chemical binding]; other site 1278073013701 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1278073013702 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1278073013703 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1278073013704 N-terminal plug; other site 1278073013705 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 1278073013706 ligand-binding site [chemical binding]; other site 1278073013707 Protein of unknown function, DUF399; Region: DUF399; cl01139 1278073013708 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073013709 classical (c) SDRs; Region: SDR_c; cd05233 1278073013710 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1278073013711 NAD(P) binding site [chemical binding]; other site 1278073013712 active site 1278073013713 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 1278073013714 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1278073013715 active site 2 [active] 1278073013716 active site 1 [active] 1278073013717 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 1278073013718 B12 binding domain (B12-BD). This domain binds different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide, it is found in several enzymes, such as glutamate mutase, methionine synthase...; Region: B12-binding; cd02067 1278073013719 B12 binding site [chemical binding]; other site 1278073013720 cobalt ligand [ion binding]; other site 1278073013721 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 1278073013722 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1278073013723 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 1278073013724 tetramer interface [polypeptide binding]; other site 1278073013725 heme binding pocket [chemical binding]; other site 1278073013726 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1278073013727 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1278073013728 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1278073013729 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1278073013730 NAD(P) binding site [chemical binding]; other site 1278073013731 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1278073013732 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1278073013733 Fe-S cluster binding site [ion binding]; other site 1278073013734 active site 1278073013735 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1278073013736 Flavoprotein; Region: Flavoprotein; pfam02441 1278073013737 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1278073013738 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073013739 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073013740 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073013741 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073013742 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073013743 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073013744 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073013745 Transmembrane protein; Region: Macoilin; pfam09726 1278073013746 Protein phosphatase 2C; Region: PP2C; pfam00481 1278073013747 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1278073013748 active site 1278073013749 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1278073013750 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1278073013751 ligand binding site [chemical binding]; other site 1278073013752 flexible hinge region; other site 1278073013753 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1278073013754 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1278073013755 phosphopeptide binding site; other site 1278073013756 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 1278073013757 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1278073013758 Outer membrane efflux protein; Region: OEP; pfam02321 1278073013759 Outer membrane efflux protein; Region: OEP; pfam02321 1278073013760 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 1278073013761 HlyD family secretion protein; Region: HlyD_3; pfam13437 1278073013762 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1278073013763 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1278073013764 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073013765 active site 1278073013766 phosphorylation site [posttranslational modification] 1278073013767 intermolecular recognition site; other site 1278073013768 dimerization interface [polypeptide binding]; other site 1278073013769 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073013770 Walker A motif; other site 1278073013771 ATP binding site [chemical binding]; other site 1278073013772 Walker B motif; other site 1278073013773 arginine finger; other site 1278073013774 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1278073013775 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1278073013776 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1278073013777 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1278073013778 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1278073013779 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1278073013780 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 1278073013781 RHS Repeat; Region: RHS_repeat; pfam05593 1278073013782 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1278073013783 RHS Repeat; Region: RHS_repeat; cl11982 1278073013784 RHS Repeat; Region: RHS_repeat; pfam05593 1278073013785 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1278073013786 RHS Repeat; Region: RHS_repeat; pfam05593 1278073013787 RHS Repeat; Region: RHS_repeat; cl11982 1278073013788 RHS Repeat; Region: RHS_repeat; pfam05593 1278073013789 RHS protein; Region: RHS; pfam03527 1278073013790 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1278073013791 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1278073013792 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1278073013793 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1278073013794 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 1278073013795 PAAR motif; Region: PAAR_motif; pfam05488 1278073013796 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 1278073013797 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1278073013798 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1278073013799 Domain of unknown function (DUF329); Region: DUF329; pfam03884 1278073013800 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 1278073013801 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 1278073013802 NAD(P) binding site [chemical binding]; other site 1278073013803 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073013804 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073013805 active site 1278073013806 ATP binding site [chemical binding]; other site 1278073013807 substrate binding site [chemical binding]; other site 1278073013808 activation loop (A-loop); other site 1278073013809 AAA ATPase domain; Region: AAA_16; pfam13191 1278073013810 TPR repeat; Region: TPR_11; pfam13414 1278073013811 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073013812 binding surface 1278073013813 TPR motif; other site 1278073013814 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1278073013815 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1278073013816 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1278073013817 agmatinase; Region: agmatinase; TIGR01230 1278073013818 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 1278073013819 putative active site [active] 1278073013820 Mn binding site [ion binding]; other site 1278073013821 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073013822 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073013823 active site 1278073013824 phosphorylation site [posttranslational modification] 1278073013825 intermolecular recognition site; other site 1278073013826 dimerization interface [polypeptide binding]; other site 1278073013827 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1278073013828 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1278073013829 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1278073013830 protein binding site [polypeptide binding]; other site 1278073013831 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1278073013832 protein binding site [polypeptide binding]; other site 1278073013833 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1278073013834 active site 1278073013835 ATP binding site [chemical binding]; other site 1278073013836 substrate binding site [chemical binding]; other site 1278073013837 activation loop (A-loop); other site 1278073013838 PEGA domain; Region: PEGA; pfam08308 1278073013839 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073013840 HAMP domain; Region: HAMP; pfam00672 1278073013841 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 1278073013842 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073013843 ATP binding site [chemical binding]; other site 1278073013844 Mg2+ binding site [ion binding]; other site 1278073013845 G-X-G motif; other site 1278073013846 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073013847 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073013848 active site 1278073013849 intermolecular recognition site; other site 1278073013850 dimerization interface [polypeptide binding]; other site 1278073013851 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1278073013852 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1278073013853 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1278073013854 active site 1278073013855 metal binding site [ion binding]; metal-binding site 1278073013856 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073013857 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073013858 active site 1278073013859 phosphorylation site [posttranslational modification] 1278073013860 intermolecular recognition site; other site 1278073013861 dimerization interface [polypeptide binding]; other site 1278073013862 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 1278073013863 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1278073013864 FecR protein; Region: FecR; pfam04773 1278073013865 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073013866 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1278073013867 dimerization interface [polypeptide binding]; other site 1278073013868 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073013869 phosphorylation site [posttranslational modification] 1278073013870 dimer interface [polypeptide binding]; other site 1278073013871 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073013872 ATP binding site [chemical binding]; other site 1278073013873 Mg2+ binding site [ion binding]; other site 1278073013874 G-X-G motif; other site 1278073013875 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073013876 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073013877 active site 1278073013878 phosphorylation site [posttranslational modification] 1278073013879 intermolecular recognition site; other site 1278073013880 dimerization interface [polypeptide binding]; other site 1278073013881 GAF domain; Region: GAF_3; pfam13492 1278073013882 GAF domain; Region: GAF_2; pfam13185 1278073013883 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1278073013884 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073013885 dimer interface [polypeptide binding]; other site 1278073013886 phosphorylation site [posttranslational modification] 1278073013887 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073013888 ATP binding site [chemical binding]; other site 1278073013889 G-X-G motif; other site 1278073013890 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073013891 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073013892 active site 1278073013893 phosphorylation site [posttranslational modification] 1278073013894 intermolecular recognition site; other site 1278073013895 dimerization interface [polypeptide binding]; other site 1278073013896 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073013897 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073013898 active site 1278073013899 phosphorylation site [posttranslational modification] 1278073013900 intermolecular recognition site; other site 1278073013901 dimerization interface [polypeptide binding]; other site 1278073013902 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1278073013903 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1278073013904 metal binding site [ion binding]; metal-binding site 1278073013905 active site 1278073013906 I-site; other site 1278073013907 LexA repressor; Validated; Region: PRK00215 1278073013908 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1278073013909 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1278073013910 Catalytic site [active] 1278073013911 TPR repeat; Region: TPR_11; pfam13414 1278073013912 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073013913 TPR motif; other site 1278073013914 binding surface 1278073013915 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1278073013916 Predicted integral membrane protein [Function unknown]; Region: COG5616 1278073013917 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1278073013918 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1278073013919 Peptidase family M23; Region: Peptidase_M23; pfam01551 1278073013920 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1278073013921 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1278073013922 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 1278073013923 hydrophobic ligand binding site; other site 1278073013924 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1278073013925 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1278073013926 putative active site [active] 1278073013927 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1278073013928 active site 1278073013929 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1278073013930 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1278073013931 HTH domain; Region: HTH_11; pfam08279 1278073013932 WYL domain; Region: WYL; pfam13280 1278073013933 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 1278073013934 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1278073013935 dimerization interface [polypeptide binding]; other site 1278073013936 active site 1278073013937 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1278073013938 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1278073013939 HIGH motif; other site 1278073013940 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1278073013941 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1278073013942 active site 1278073013943 KMSKS motif; other site 1278073013944 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1278073013945 tRNA binding surface [nucleotide binding]; other site 1278073013946 anticodon binding site; other site 1278073013947 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1278073013948 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073013949 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073013950 active site 1278073013951 phosphorylation site [posttranslational modification] 1278073013952 intermolecular recognition site; other site 1278073013953 dimerization interface [polypeptide binding]; other site 1278073013954 CheW-like domain; Region: CheW; pfam01584 1278073013955 CheW-like domain; Region: CheW; pfam01584 1278073013956 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073013957 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073013958 active site 1278073013959 phosphorylation site [posttranslational modification] 1278073013960 intermolecular recognition site; other site 1278073013961 dimerization interface [polypeptide binding]; other site 1278073013962 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1278073013963 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1278073013964 metal binding site [ion binding]; metal-binding site 1278073013965 active site 1278073013966 I-site; other site 1278073013967 Uncharacterized conserved protein [Function unknown]; Region: COG3461 1278073013968 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073013969 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073013970 dimer interface [polypeptide binding]; other site 1278073013971 phosphorylation site [posttranslational modification] 1278073013972 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073013973 ATP binding site [chemical binding]; other site 1278073013974 Mg2+ binding site [ion binding]; other site 1278073013975 G-X-G motif; other site 1278073013976 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073013977 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073013978 active site 1278073013979 phosphorylation site [posttranslational modification] 1278073013980 intermolecular recognition site; other site 1278073013981 dimerization interface [polypeptide binding]; other site 1278073013982 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1278073013983 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1278073013984 ring oligomerisation interface [polypeptide binding]; other site 1278073013985 ATP/Mg binding site [chemical binding]; other site 1278073013986 stacking interactions; other site 1278073013987 hinge regions; other site 1278073013988 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073013989 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073013990 active site 1278073013991 phosphorylation site [posttranslational modification] 1278073013992 intermolecular recognition site; other site 1278073013993 dimerization interface [polypeptide binding]; other site 1278073013994 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1278073013995 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073013996 binding surface 1278073013997 TPR motif; other site 1278073013998 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073013999 binding surface 1278073014000 TPR motif; other site 1278073014001 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1278073014002 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1278073014003 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1278073014004 atypical (a) SDRs, subgroup 3; Region: SDR_a3; cd05229 1278073014005 putative NAD(P) binding site [chemical binding]; other site 1278073014006 putative active site [active] 1278073014007 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1278073014008 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1278073014009 WHG domain; Region: WHG; pfam13305 1278073014010 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 1278073014011 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 1278073014012 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1278073014013 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 1278073014014 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 1278073014015 active site 1278073014016 catalytic triad [active] 1278073014017 dimer interface [polypeptide binding]; other site 1278073014018 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 1278073014019 methyltransferase, TIGR00027 family; Region: mthyl_TIGR00027 1278073014020 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1278073014021 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1278073014022 Condensation domain; Region: Condensation; pfam00668 1278073014023 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073014024 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073014025 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1278073014026 acyl-activating enzyme (AAE) consensus motif; other site 1278073014027 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1278073014028 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 1278073014029 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1278073014030 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073014031 AMP binding site [chemical binding]; other site 1278073014032 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073014033 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1278073014034 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073014035 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1278073014036 active site 1278073014037 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1278073014038 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1278073014039 Methyltransferase in polyketide synthase (PKS) enzymes; Region: PKS_MT; smart00828 1278073014040 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073014041 S-adenosylmethionine binding site [chemical binding]; other site 1278073014042 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073014043 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1278073014044 active site 1278073014045 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1278073014046 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1278073014047 Methyltransferase in polyketide synthase (PKS) enzymes; Region: PKS_MT; smart00828 1278073014048 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073014049 S-adenosylmethionine binding site [chemical binding]; other site 1278073014050 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1278073014051 KR domain; Region: KR; pfam08659 1278073014052 putative NADP binding site [chemical binding]; other site 1278073014053 active site 1278073014054 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1278073014055 Condensation domain; Region: Condensation; pfam00668 1278073014056 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073014057 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1278073014058 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1278073014059 acyl-activating enzyme (AAE) consensus motif; other site 1278073014060 AMP binding site [chemical binding]; other site 1278073014061 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1278073014062 putative FMN binding site [chemical binding]; other site 1278073014063 NADPH bind site [chemical binding]; other site 1278073014064 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1278073014065 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073014066 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1278073014067 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073014068 active site 1278073014069 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1278073014070 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1278073014071 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1278073014072 KR domain; Region: KR; pfam08659 1278073014073 putative NADP binding site [chemical binding]; other site 1278073014074 active site 1278073014075 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1278073014076 Condensation domain; Region: Condensation; pfam00668 1278073014077 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073014078 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1278073014079 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1278073014080 acyl-activating enzyme (AAE) consensus motif; other site 1278073014081 AMP binding site [chemical binding]; other site 1278073014082 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073014083 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1278073014084 NADPH bind site [chemical binding]; other site 1278073014085 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1278073014086 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1278073014087 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1278073014088 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1278073014089 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1278073014090 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1278073014091 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073014092 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1278073014093 active site 1278073014094 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1278073014095 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1278073014096 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1278073014097 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1278073014098 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1278073014099 homotetramer interface [polypeptide binding]; other site 1278073014100 ligand binding site [chemical binding]; other site 1278073014101 catalytic site [active] 1278073014102 NAD binding site [chemical binding]; other site 1278073014103 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 1278073014104 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1278073014105 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1278073014106 homodimer interface [polypeptide binding]; other site 1278073014107 NADP binding site [chemical binding]; other site 1278073014108 substrate binding site [chemical binding]; other site 1278073014109 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 1278073014110 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1278073014111 dimer interface [polypeptide binding]; other site 1278073014112 active site 1278073014113 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1278073014114 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1278073014115 substrate binding site [chemical binding]; other site 1278073014116 oxyanion hole (OAH) forming residues; other site 1278073014117 trimer interface [polypeptide binding]; other site 1278073014118 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1278073014119 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1278073014120 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073014121 S-adenosylmethionine binding site [chemical binding]; other site 1278073014122 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1278073014123 lysine biosynthesis protein LysW; Region: lysW; TIGR01206 1278073014124 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1278073014125 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073014126 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1278073014127 acyl-activating enzyme (AAE) consensus motif; other site 1278073014128 AMP binding site [chemical binding]; other site 1278073014129 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073014130 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1278073014131 enolase; Provisional; Region: eno; PRK00077 1278073014132 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1278073014133 dimer interface [polypeptide binding]; other site 1278073014134 metal binding site [ion binding]; metal-binding site 1278073014135 substrate binding pocket [chemical binding]; other site 1278073014136 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 1278073014137 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 1278073014138 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1278073014139 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 1278073014140 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 1278073014141 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 1278073014142 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 1278073014143 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1278073014144 Domain of unknown function (DUF955); Region: DUF955; cl01076 1278073014145 HerA helicase [Replication, recombination, and repair]; Region: COG0433 1278073014146 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1278073014147 putative catalytic site [active] 1278073014148 putative metal binding site [ion binding]; other site 1278073014149 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1278073014150 putative catalytic site [active] 1278073014151 putative phosphate binding site [ion binding]; other site 1278073014152 putative phosphate binding site [ion binding]; other site 1278073014153 putative metal binding site [ion binding]; other site 1278073014154 YceI-like domain; Region: YceI; smart00867 1278073014155 cyclase homology domain; Region: CHD; cd07302 1278073014156 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1278073014157 nucleotidyl binding site; other site 1278073014158 metal binding site [ion binding]; metal-binding site 1278073014159 dimer interface [polypeptide binding]; other site 1278073014160 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1278073014161 cyclase homology domain; Region: CHD; cd07302 1278073014162 dimer interface [polypeptide binding]; other site 1278073014163 nucleotidyl binding site; other site 1278073014164 metal binding site [ion binding]; metal-binding site 1278073014165 Predicted ATPase [General function prediction only]; Region: COG3899 1278073014166 AAA ATPase domain; Region: AAA_16; pfam13191 1278073014167 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073014168 binding surface 1278073014169 TPR motif; other site 1278073014170 TPR repeat; Region: TPR_11; pfam13414 1278073014171 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1278073014172 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1278073014173 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073014174 active site 1278073014175 ATP binding site [chemical binding]; other site 1278073014176 substrate binding site [chemical binding]; other site 1278073014177 activation loop (A-loop); other site 1278073014178 AAA ATPase domain; Region: AAA_16; pfam13191 1278073014179 Predicted ATPase [General function prediction only]; Region: COG3899 1278073014180 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1278073014181 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1278073014182 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1278073014183 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1278073014184 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073014185 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073014186 dimer interface [polypeptide binding]; other site 1278073014187 phosphorylation site [posttranslational modification] 1278073014188 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073014189 ATP binding site [chemical binding]; other site 1278073014190 Mg2+ binding site [ion binding]; other site 1278073014191 G-X-G motif; other site 1278073014192 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 1278073014193 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1278073014194 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 1278073014195 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 1278073014196 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 1278073014197 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 1278073014198 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1278073014199 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073014200 active site 1278073014201 ATP binding site [chemical binding]; other site 1278073014202 substrate binding site [chemical binding]; other site 1278073014203 activation loop (A-loop); other site 1278073014204 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 1278073014205 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1278073014206 N-terminal plug; other site 1278073014207 ligand-binding site [chemical binding]; other site 1278073014208 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1278073014209 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073014210 TPR motif; other site 1278073014211 binding surface 1278073014212 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073014213 binding surface 1278073014214 TPR motif; other site 1278073014215 TPR repeat; Region: TPR_11; pfam13414 1278073014216 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073014217 TPR motif; other site 1278073014218 binding surface 1278073014219 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1278073014220 dimerization interface [polypeptide binding]; other site 1278073014221 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1278073014222 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 1278073014223 Peptidase family M50; Region: Peptidase_M50; pfam02163 1278073014224 active site 1278073014225 putative substrate binding region [chemical binding]; other site 1278073014226 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1278073014227 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1278073014228 tetramer interface [polypeptide binding]; other site 1278073014229 TPP-binding site [chemical binding]; other site 1278073014230 heterodimer interface [polypeptide binding]; other site 1278073014231 phosphorylation loop region [posttranslational modification] 1278073014232 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1278073014233 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1278073014234 PYR/PP interface [polypeptide binding]; other site 1278073014235 dimer interface [polypeptide binding]; other site 1278073014236 TPP binding site [chemical binding]; other site 1278073014237 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1278073014238 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1278073014239 Coenzyme A binding pocket [chemical binding]; other site 1278073014240 PilZ domain; Region: PilZ; cl01260 1278073014241 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1278073014242 active site 1278073014243 catalytic triad [active] 1278073014244 oxyanion hole [active] 1278073014245 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 1278073014246 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 1278073014247 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1278073014248 ATP binding site [chemical binding]; other site 1278073014249 putative Mg++ binding site [ion binding]; other site 1278073014250 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1278073014251 nucleotide binding region [chemical binding]; other site 1278073014252 ATP-binding site [chemical binding]; other site 1278073014253 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 1278073014254 Glyoxal oxidase N-terminus; Region: Glyoxal_oxid_N; pfam07250 1278073014255 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1278073014256 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1278073014257 Kelch motif; Region: Kelch_6; pfam13964 1278073014258 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 1278073014259 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 1278073014260 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1278073014261 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1278073014262 CoA binding domain; Region: CoA_binding_2; pfam13380 1278073014263 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1278073014264 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1278073014265 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1278073014266 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1278073014267 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1278073014268 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1278073014269 FAD binding pocket [chemical binding]; other site 1278073014270 conserved FAD binding motif [chemical binding]; other site 1278073014271 phosphate binding motif [ion binding]; other site 1278073014272 beta-alpha-beta structure motif; other site 1278073014273 NAD binding pocket [chemical binding]; other site 1278073014274 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1278073014275 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1278073014276 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1278073014277 putative effector binding pocket; other site 1278073014278 putative dimerization interface [polypeptide binding]; other site 1278073014279 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 1278073014280 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1278073014281 active sites [active] 1278073014282 tetramer interface [polypeptide binding]; other site 1278073014283 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073014284 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1278073014285 active site 1278073014286 ATP binding site [chemical binding]; other site 1278073014287 substrate binding site [chemical binding]; other site 1278073014288 activation loop (A-loop); other site 1278073014289 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1278073014290 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1278073014291 Tetratricopeptide repeat; Region: TPR_10; pfam13374 1278073014292 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1278073014293 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1278073014294 Tetratricopeptide repeat; Region: TPR_10; pfam13374 1278073014295 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1278073014296 NmrA (a transcriptional regulator) and triphenylmethane reductase (TMR) like proteins, subgroup 1, atypical (a) SDRs; Region: NmrA_TMR_like_1_SDR_a; cd05231 1278073014297 putative NADP binding site [chemical binding]; other site 1278073014298 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1278073014299 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1278073014300 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1278073014301 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1278073014302 substrate binding pocket [chemical binding]; other site 1278073014303 dimerization interface [polypeptide binding]; other site 1278073014304 Myxococcales-restricted protein, TIGR02265 family; Region: Mxa_TIGR02265 1278073014305 Protein of unknown function (DUF3014); Region: DUF3014; pfam11219 1278073014306 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1278073014307 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073014308 dimer interface [polypeptide binding]; other site 1278073014309 phosphorylation site [posttranslational modification] 1278073014310 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073014311 ATP binding site [chemical binding]; other site 1278073014312 G-X-G motif; other site 1278073014313 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1278073014314 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073014315 active site 1278073014316 phosphorylation site [posttranslational modification] 1278073014317 intermolecular recognition site; other site 1278073014318 dimerization interface [polypeptide binding]; other site 1278073014319 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073014320 Walker A motif; other site 1278073014321 ATP binding site [chemical binding]; other site 1278073014322 Walker B motif; other site 1278073014323 arginine finger; other site 1278073014324 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1278073014325 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 1278073014326 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1278073014327 ligand binding site [chemical binding]; other site 1278073014328 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1278073014329 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 1278073014330 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1278073014331 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1278073014332 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1278073014333 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073014334 Walker A/P-loop; other site 1278073014335 ATP binding site [chemical binding]; other site 1278073014336 Q-loop/lid; other site 1278073014337 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1278073014338 ABC transporter signature motif; other site 1278073014339 Walker B; other site 1278073014340 D-loop; other site 1278073014341 ABC transporter; Region: ABC_tran_2; pfam12848 1278073014342 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1278073014343 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1278073014344 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073014345 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1278073014346 SnoaL-like domain; Region: SnoaL_2; pfam12680 1278073014347 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 1278073014348 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1278073014349 Transcriptional regulator; Region: Rrf2; pfam02082 1278073014350 Rrf2 family protein; Region: rrf2_super; TIGR00738 1278073014351 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 1278073014352 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 1278073014353 Fn3 associated; Region: Fn3_assoc; pfam13287 1278073014354 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 1278073014355 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 1278073014356 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 1278073014357 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1278073014358 PEGA domain; Region: PEGA; pfam08308 1278073014359 PEGA domain; Region: PEGA; pfam08308 1278073014360 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1278073014361 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073014362 active site 1278073014363 ATP binding site [chemical binding]; other site 1278073014364 substrate binding site [chemical binding]; other site 1278073014365 activation loop (A-loop); other site 1278073014366 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1278073014367 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1278073014368 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1278073014369 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1278073014370 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 1278073014371 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1278073014372 dimerization interface [polypeptide binding]; other site 1278073014373 putative DNA binding site [nucleotide binding]; other site 1278073014374 putative Zn2+ binding site [ion binding]; other site 1278073014375 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1278073014376 hydrophobic ligand binding site; other site 1278073014377 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1278073014378 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1278073014379 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1278073014380 substrate binding site; other site 1278073014381 tetramer interface; other site 1278073014382 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1278073014383 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1278073014384 NADP binding site [chemical binding]; other site 1278073014385 active site 1278073014386 putative substrate binding site [chemical binding]; other site 1278073014387 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1278073014388 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1278073014389 NAD binding site [chemical binding]; other site 1278073014390 substrate binding site [chemical binding]; other site 1278073014391 homodimer interface [polypeptide binding]; other site 1278073014392 active site 1278073014393 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1278073014394 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1278073014395 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1278073014396 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1278073014397 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1278073014398 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1278073014399 active site 1278073014400 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1278073014401 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1278073014402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073014403 S-adenosylmethionine binding site [chemical binding]; other site 1278073014404 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1278073014405 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1278073014406 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 1278073014407 Probable Catalytic site; other site 1278073014408 metal-binding site 1278073014409 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1278073014410 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1278073014411 Probable Catalytic site; other site 1278073014412 metal-binding site 1278073014413 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1278073014414 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1278073014415 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1278073014416 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1278073014417 Walker A/P-loop; other site 1278073014418 ATP binding site [chemical binding]; other site 1278073014419 Q-loop/lid; other site 1278073014420 ABC transporter signature motif; other site 1278073014421 Walker B; other site 1278073014422 D-loop; other site 1278073014423 H-loop/switch region; other site 1278073014424 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 1278073014425 putative carbohydrate binding site [chemical binding]; other site 1278073014426 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1278073014427 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1278073014428 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1278073014429 TPR repeat; Region: TPR_11; pfam13414 1278073014430 TPR repeat; Region: TPR_11; pfam13414 1278073014431 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073014432 binding surface 1278073014433 TPR motif; other site 1278073014434 TPR repeat; Region: TPR_11; pfam13414 1278073014435 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 1278073014436 Domain of unknown function (DUF4124); Region: DUF4124; pfam13511 1278073014437 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1278073014438 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1278073014439 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1278073014440 catalytic residue [active] 1278073014441 L-aspartate oxidase; Provisional; Region: PRK09077 1278073014442 L-aspartate oxidase; Provisional; Region: PRK06175 1278073014443 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1278073014444 Rhomboid family; Region: Rhomboid; pfam01694 1278073014445 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1278073014446 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1278073014447 active site 1278073014448 ParB-like nuclease domain; Region: ParBc; pfam02195 1278073014449 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1278073014450 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1278073014451 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1278073014452 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1278073014453 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1278073014454 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1278073014455 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073014456 TPR motif; other site 1278073014457 binding surface 1278073014458 TPR repeat; Region: TPR_11; pfam13414 1278073014459 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073014460 binding surface 1278073014461 TPR motif; other site 1278073014462 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1278073014463 TPR motif; other site 1278073014464 binding surface 1278073014465 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073014466 TPR repeat; Region: TPR_11; pfam13414 1278073014467 binding surface 1278073014468 TPR motif; other site 1278073014469 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1278073014470 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1278073014471 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 1278073014472 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073014473 ATP binding site [chemical binding]; other site 1278073014474 Mg2+ binding site [ion binding]; other site 1278073014475 G-X-G motif; other site 1278073014476 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073014477 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073014478 active site 1278073014479 phosphorylation site [posttranslational modification] 1278073014480 intermolecular recognition site; other site 1278073014481 dimerization interface [polypeptide binding]; other site 1278073014482 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1278073014483 I-site; other site 1278073014484 active site 1278073014485 metal binding site [ion binding]; metal-binding site 1278073014486 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1278073014487 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1278073014488 RNA binding surface [nucleotide binding]; other site 1278073014489 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1278073014490 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1278073014491 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1278073014492 TPP-binding site; other site 1278073014493 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1278073014494 PYR/PP interface [polypeptide binding]; other site 1278073014495 dimer interface [polypeptide binding]; other site 1278073014496 TPP binding site [chemical binding]; other site 1278073014497 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1278073014498 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1278073014499 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1278073014500 substrate binding pocket [chemical binding]; other site 1278073014501 chain length determination region; other site 1278073014502 substrate-Mg2+ binding site; other site 1278073014503 catalytic residues [active] 1278073014504 aspartate-rich region 1; other site 1278073014505 active site lid residues [active] 1278073014506 aspartate-rich region 2; other site 1278073014507 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073014508 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073014509 active site 1278073014510 phosphorylation site [posttranslational modification] 1278073014511 intermolecular recognition site; other site 1278073014512 dimerization interface [polypeptide binding]; other site 1278073014513 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1278073014514 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1278073014515 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1278073014516 generic binding surface II; other site 1278073014517 generic binding surface I; other site 1278073014518 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1278073014519 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1278073014520 phosphopeptide binding site; other site 1278073014521 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1278073014522 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1278073014523 phosphopeptide binding site; other site 1278073014524 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 1278073014525 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1278073014526 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1278073014527 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1278073014528 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 1278073014529 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1278073014530 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 1278073014531 TadE-like protein; Region: TadE; pfam07811 1278073014532 TadE-like protein; Region: TadE; pfam07811 1278073014533 Putative zinc-finger; Region: zf-HC2; pfam13490 1278073014534 RNA polymerase sigma factor; Provisional; Region: PRK12513 1278073014535 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073014536 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1278073014537 DNA binding residues [nucleotide binding] 1278073014538 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1278073014539 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1278073014540 Walker A/P-loop; other site 1278073014541 ATP binding site [chemical binding]; other site 1278073014542 Q-loop/lid; other site 1278073014543 ABC transporter signature motif; other site 1278073014544 Walker B; other site 1278073014545 D-loop; other site 1278073014546 H-loop/switch region; other site 1278073014547 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1278073014548 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1278073014549 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1278073014550 Walker A/P-loop; other site 1278073014551 ATP binding site [chemical binding]; other site 1278073014552 Q-loop/lid; other site 1278073014553 ABC transporter signature motif; other site 1278073014554 Walker B; other site 1278073014555 D-loop; other site 1278073014556 H-loop/switch region; other site 1278073014557 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1278073014558 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1278073014559 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1278073014560 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125 1278073014561 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1278073014562 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1278073014563 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1278073014564 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1278073014565 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1278073014566 active site 1278073014567 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 1278073014568 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 1278073014569 active site 1278073014570 catalytic site [active] 1278073014571 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 1278073014572 active site 1278073014573 catalytic site [active] 1278073014574 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1278073014575 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1278073014576 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 1278073014577 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073014578 active site 1278073014579 phosphorylation site [posttranslational modification] 1278073014580 intermolecular recognition site; other site 1278073014581 dimerization interface [polypeptide binding]; other site 1278073014582 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1278073014583 Zn2+ binding site [ion binding]; other site 1278073014584 Mg2+ binding site [ion binding]; other site 1278073014585 HEAT repeats; Region: HEAT_2; pfam13646 1278073014586 HEAT repeats; Region: HEAT_2; pfam13646 1278073014587 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1278073014588 active site 1278073014589 MoxR-like ATPases [General function prediction only]; Region: COG0714 1278073014590 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073014591 Walker A motif; other site 1278073014592 ATP binding site [chemical binding]; other site 1278073014593 Walker B motif; other site 1278073014594 arginine finger; other site 1278073014595 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1278073014596 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1278073014597 metal ion-dependent adhesion site (MIDAS); other site 1278073014598 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1278073014599 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1278073014600 ATP binding site [chemical binding]; other site 1278073014601 putative Mg++ binding site [ion binding]; other site 1278073014602 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1278073014603 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1278073014604 nucleotide binding region [chemical binding]; other site 1278073014605 ATP-binding site [chemical binding]; other site 1278073014606 Smr domain; Region: Smr; pfam01713 1278073014607 Protein of unknown function DUF72; Region: DUF72; pfam01904 1278073014608 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1278073014609 twin-arg-translocated uncharacterized repeat protein; Region: RR_plus_rpt_1; TIGR03808 1278073014610 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1278073014611 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1278073014612 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1278073014613 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1278073014614 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1278073014615 DNA-binding site [nucleotide binding]; DNA binding site 1278073014616 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1278073014617 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1278073014618 homodimer interface [polypeptide binding]; other site 1278073014619 catalytic residue [active] 1278073014620 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1278073014621 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1278073014622 dimer interface [polypeptide binding]; other site 1278073014623 anticodon binding site; other site 1278073014624 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1278073014625 homodimer interface [polypeptide binding]; other site 1278073014626 motif 1; other site 1278073014627 active site 1278073014628 motif 2; other site 1278073014629 GAD domain; Region: GAD; pfam02938 1278073014630 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1278073014631 active site 1278073014632 motif 3; other site 1278073014633 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1278073014634 Zn binding site [ion binding]; other site 1278073014635 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 1278073014636 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1278073014637 DHH family; Region: DHH; pfam01368 1278073014638 DHHA1 domain; Region: DHHA1; pfam02272 1278073014639 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1278073014640 protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966 1278073014641 Protein export membrane protein; Region: SecD_SecF; pfam02355 1278073014642 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 1278073014643 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1278073014644 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1278073014645 Preprotein translocase subunit; Region: YajC; pfam02699 1278073014646 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1278073014647 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1278073014648 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1278073014649 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1278073014650 Stage II sporulation protein; Region: SpoIID; pfam08486 1278073014651 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1278073014652 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 1278073014653 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1278073014654 FeS/SAM binding site; other site 1278073014655 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 1278073014656 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 1278073014657 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1278073014658 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1278073014659 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073014660 active site 1278073014661 ATP binding site [chemical binding]; other site 1278073014662 substrate binding site [chemical binding]; other site 1278073014663 activation loop (A-loop); other site 1278073014664 PEGA domain; Region: PEGA; pfam08308 1278073014665 PEGA domain; Region: PEGA; pfam08308 1278073014666 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1278073014667 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1278073014668 catalytic site [active] 1278073014669 G-X2-G-X-G-K; other site 1278073014670 hypothetical protein; Provisional; Region: PRK11820 1278073014671 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1278073014672 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1278073014673 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1278073014674 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1278073014675 putative active site [active] 1278073014676 Trm112p-like protein; Region: Trm112p; cl01066 1278073014677 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1278073014678 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 1278073014679 active site 1278073014680 nucleotide binding site [chemical binding]; other site 1278073014681 HIGH motif; other site 1278073014682 KMSKS motif; other site 1278073014683 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1278073014684 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 1278073014685 substrate binding site [chemical binding]; other site 1278073014686 ATP binding site [chemical binding]; other site 1278073014687 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 1278073014688 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1278073014689 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1278073014690 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1278073014691 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1278073014692 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1278073014693 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1278073014694 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1278073014695 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 1278073014696 active site 1278073014697 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1278073014698 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1278073014699 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073014700 Walker A/P-loop; other site 1278073014701 ATP binding site [chemical binding]; other site 1278073014702 Q-loop/lid; other site 1278073014703 ABC transporter signature motif; other site 1278073014704 Walker B; other site 1278073014705 D-loop; other site 1278073014706 H-loop/switch region; other site 1278073014707 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073014708 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073014709 active site 1278073014710 phosphorylation site [posttranslational modification] 1278073014711 intermolecular recognition site; other site 1278073014712 dimerization interface [polypeptide binding]; other site 1278073014713 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 1278073014714 DnaJ domain; Region: DnaJ; pfam00226 1278073014715 TPR repeat; Region: TPR_11; pfam13414 1278073014716 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1278073014717 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1278073014718 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1278073014719 Ligand binding site; other site 1278073014720 Putative Catalytic site; other site 1278073014721 DXD motif; other site 1278073014722 MarC family integral membrane protein; Region: MarC; pfam01914 1278073014723 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1278073014724 ligand binding site [chemical binding]; other site 1278073014725 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 1278073014726 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1278073014727 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1278073014728 active site 1278073014729 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1278073014730 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1278073014731 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1278073014732 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1278073014733 trimer interface [polypeptide binding]; other site 1278073014734 active site 1278073014735 UDP-GlcNAc binding site [chemical binding]; other site 1278073014736 lipid binding site [chemical binding]; lipid-binding site 1278073014737 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 1278073014738 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 1278073014739 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1278073014740 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1278073014741 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1278073014742 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1278073014743 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1278073014744 Surface antigen; Region: Bac_surface_Ag; pfam01103 1278073014745 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1278073014746 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1278073014747 Walker A/P-loop; other site 1278073014748 ATP binding site [chemical binding]; other site 1278073014749 Q-loop/lid; other site 1278073014750 ABC transporter signature motif; other site 1278073014751 Walker B; other site 1278073014752 D-loop; other site 1278073014753 H-loop/switch region; other site 1278073014754 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1278073014755 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1278073014756 FtsX-like permease family; Region: FtsX; pfam02687 1278073014757 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1278073014758 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1278073014759 dimer interface [polypeptide binding]; other site 1278073014760 putative anticodon binding site; other site 1278073014761 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1278073014762 motif 1; other site 1278073014763 active site 1278073014764 motif 2; other site 1278073014765 motif 3; other site 1278073014766 Putative zinc-finger; Region: zf-HC2; pfam13490 1278073014767 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1278073014768 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073014769 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1278073014770 DNA binding residues [nucleotide binding] 1278073014771 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1278073014772 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1278073014773 RF-1 domain; Region: RF-1; pfam00472 1278073014774 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 1278073014775 Cupin domain; Region: Cupin_2; pfam07883 1278073014776 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 1278073014777 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 1278073014778 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 1278073014779 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1278073014780 Zn2+ binding site [ion binding]; other site 1278073014781 Mg2+ binding site [ion binding]; other site 1278073014782 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1278073014783 PhoH-like protein; Region: PhoH; pfam02562 1278073014784 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 1278073014785 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073014786 binding surface 1278073014787 TPR repeat; Region: TPR_11; pfam13414 1278073014788 TPR motif; other site 1278073014789 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1278073014790 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1278073014791 homodimer interface [polypeptide binding]; other site 1278073014792 metal binding site [ion binding]; metal-binding site 1278073014793 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1278073014794 homodimer interface [polypeptide binding]; other site 1278073014795 active site 1278073014796 putative chemical substrate binding site [chemical binding]; other site 1278073014797 metal binding site [ion binding]; metal-binding site 1278073014798 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1278073014799 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1278073014800 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1278073014801 HIGH motif; other site 1278073014802 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1278073014803 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1278073014804 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1278073014805 active site 1278073014806 KMSKS motif; other site 1278073014807 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1278073014808 tRNA binding surface [nucleotide binding]; other site 1278073014809 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 1278073014810 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1278073014811 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 1278073014812 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1278073014813 starch binding outer membrane protein SusD; Region: SusD; cd08977 1278073014814 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1278073014815 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1278073014816 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1278073014817 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1278073014818 Walker A/P-loop; other site 1278073014819 ATP binding site [chemical binding]; other site 1278073014820 Q-loop/lid; other site 1278073014821 ABC transporter signature motif; other site 1278073014822 Walker B; other site 1278073014823 D-loop; other site 1278073014824 H-loop/switch region; other site 1278073014825 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073014826 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073014827 active site 1278073014828 phosphorylation site [posttranslational modification] 1278073014829 intermolecular recognition site; other site 1278073014830 dimerization interface [polypeptide binding]; other site 1278073014831 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1278073014832 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073014833 active site 1278073014834 phosphorylation site [posttranslational modification] 1278073014835 intermolecular recognition site; other site 1278073014836 dimerization interface [polypeptide binding]; other site 1278073014837 CheB methylesterase; Region: CheB_methylest; pfam01339 1278073014838 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1278073014839 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1278073014840 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1278073014841 HEAT repeats; Region: HEAT_2; pfam13646 1278073014842 HEAT repeats; Region: HEAT_2; pfam13646 1278073014843 HEAT repeats; Region: HEAT_2; pfam13646 1278073014844 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1278073014845 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1278073014846 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1278073014847 putative binding surface; other site 1278073014848 active site 1278073014849 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1278073014850 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1278073014851 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073014852 ATP binding site [chemical binding]; other site 1278073014853 Mg2+ binding site [ion binding]; other site 1278073014854 G-X-G motif; other site 1278073014855 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1278073014856 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073014857 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073014858 active site 1278073014859 phosphorylation site [posttranslational modification] 1278073014860 intermolecular recognition site; other site 1278073014861 dimerization interface [polypeptide binding]; other site 1278073014862 Cytosol aminopeptidase family, N-terminal domain; Region: Peptidase_M17_N; pfam02789 1278073014863 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1278073014864 putative RNA binding site [nucleotide binding]; other site 1278073014865 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1278073014866 homopentamer interface [polypeptide binding]; other site 1278073014867 active site 1278073014868 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1278073014869 Lumazine binding domain; Region: Lum_binding; pfam00677 1278073014870 Lumazine binding domain; Region: Lum_binding; pfam00677 1278073014871 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1278073014872 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1278073014873 catalytic motif [active] 1278073014874 Zn binding site [ion binding]; other site 1278073014875 RibD C-terminal domain; Region: RibD_C; cl17279 1278073014876 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1278073014877 ATP cone domain; Region: ATP-cone; pfam03477 1278073014878 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1278073014879 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1278073014880 dimer interface [polypeptide binding]; other site 1278073014881 active site 1278073014882 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1278073014883 folate binding site [chemical binding]; other site 1278073014884 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 1278073014885 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1278073014886 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1278073014887 dimer interface [polypeptide binding]; other site 1278073014888 active site 1278073014889 acyl carrier protein; Provisional; Region: acpP; PRK00982 1278073014890 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1278073014891 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1278073014892 NAD(P) binding site [chemical binding]; other site 1278073014893 homotetramer interface [polypeptide binding]; other site 1278073014894 homodimer interface [polypeptide binding]; other site 1278073014895 active site 1278073014896 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1278073014897 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1278073014898 putative phosphate acyltransferase; Provisional; Region: PRK05331 1278073014899 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1278073014900 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 1278073014901 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1278073014902 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073014903 active site 1278073014904 phosphorylation site [posttranslational modification] 1278073014905 intermolecular recognition site; other site 1278073014906 dimerization interface [polypeptide binding]; other site 1278073014907 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1278073014908 DNA binding site [nucleotide binding] 1278073014909 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1278073014910 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1278073014911 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073014912 dimer interface [polypeptide binding]; other site 1278073014913 phosphorylation site [posttranslational modification] 1278073014914 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073014915 ATP binding site [chemical binding]; other site 1278073014916 Mg2+ binding site [ion binding]; other site 1278073014917 G-X-G motif; other site 1278073014918 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 1278073014919 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1278073014920 active site 1278073014921 metal binding site [ion binding]; metal-binding site 1278073014922 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1278073014923 catalytic core [active] 1278073014924 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 1278073014925 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1278073014926 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 1278073014927 active site clefts [active] 1278073014928 zinc binding site [ion binding]; other site 1278073014929 dimer interface [polypeptide binding]; other site 1278073014930 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1278073014931 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1278073014932 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1278073014933 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1278073014934 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1278073014935 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1278073014936 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073014937 active site 1278073014938 phosphorylation site [posttranslational modification] 1278073014939 intermolecular recognition site; other site 1278073014940 dimerization interface [polypeptide binding]; other site 1278073014941 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073014942 Walker A motif; other site 1278073014943 ATP binding site [chemical binding]; other site 1278073014944 Walker B motif; other site 1278073014945 arginine finger; other site 1278073014946 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1278073014947 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073014948 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1278073014949 phosphorylation site [posttranslational modification] 1278073014950 dimer interface [polypeptide binding]; other site 1278073014951 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073014952 ATP binding site [chemical binding]; other site 1278073014953 Mg2+ binding site [ion binding]; other site 1278073014954 G-X-G motif; other site 1278073014955 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 1278073014956 homodimer interface [polypeptide binding]; other site 1278073014957 catalytic residues [active] 1278073014958 NAD binding site [chemical binding]; other site 1278073014959 substrate binding pocket [chemical binding]; other site 1278073014960 flexible flap; other site 1278073014961 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 1278073014962 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073014963 active site 1278073014964 phosphorylation site [posttranslational modification] 1278073014965 intermolecular recognition site; other site 1278073014966 dimerization interface [polypeptide binding]; other site 1278073014967 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1278073014968 DNA binding site [nucleotide binding] 1278073014969 PBP superfamily domain; Region: PBP_like_2; cl17296 1278073014970 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1278073014971 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1278073014972 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1278073014973 dimer interface [polypeptide binding]; other site 1278073014974 conserved gate region; other site 1278073014975 putative PBP binding loops; other site 1278073014976 ABC-ATPase subunit interface; other site 1278073014977 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 1278073014978 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1278073014979 ABC-ATPase subunit interface; other site 1278073014980 phosphate transporter ATP-binding protein; Provisional; Region: PRK14242 1278073014981 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1278073014982 Walker A/P-loop; other site 1278073014983 ATP binding site [chemical binding]; other site 1278073014984 Q-loop/lid; other site 1278073014985 ABC transporter signature motif; other site 1278073014986 Walker B; other site 1278073014987 D-loop; other site 1278073014988 H-loop/switch region; other site 1278073014989 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1278073014990 PhoU domain; Region: PhoU; pfam01895 1278073014991 PhoU domain; Region: PhoU; pfam01895 1278073014992 hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472 1278073014993 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 1278073014994 ligand binding site; other site 1278073014995 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1278073014996 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1278073014997 active site 1278073014998 metal binding site [ion binding]; metal-binding site 1278073014999 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073015000 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073015001 active site 1278073015002 phosphorylation site [posttranslational modification] 1278073015003 intermolecular recognition site; other site 1278073015004 dimerization interface [polypeptide binding]; other site 1278073015005 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1278073015006 Domain of unknown function DUF21; Region: DUF21; pfam01595 1278073015007 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1278073015008 Transporter associated domain; Region: CorC_HlyC; smart01091 1278073015009 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1278073015010 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1278073015011 HlyD family secretion protein; Region: HlyD_3; pfam13437 1278073015012 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1278073015013 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1278073015014 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1278073015015 Helix-turn-helix domain; Region: HTH_28; pfam13518 1278073015016 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1278073015017 rod shape-determining protein MreC; Provisional; Region: PRK13922 1278073015018 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 1278073015019 30S subunit binding site; other site 1278073015020 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1278073015021 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1278073015022 catalytic residues [active] 1278073015023 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1278073015024 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1278073015025 Walker A/P-loop; other site 1278073015026 ATP binding site [chemical binding]; other site 1278073015027 Q-loop/lid; other site 1278073015028 ABC transporter signature motif; other site 1278073015029 Walker B; other site 1278073015030 D-loop; other site 1278073015031 H-loop/switch region; other site 1278073015032 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1278073015033 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1278073015034 dimer interface [polypeptide binding]; other site 1278073015035 conserved gate region; other site 1278073015036 putative PBP binding loops; other site 1278073015037 ABC-ATPase subunit interface; other site 1278073015038 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1278073015039 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1278073015040 dimer interface [polypeptide binding]; other site 1278073015041 conserved gate region; other site 1278073015042 putative PBP binding loops; other site 1278073015043 ABC-ATPase subunit interface; other site 1278073015044 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1278073015045 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1278073015046 substrate binding pocket [chemical binding]; other site 1278073015047 membrane-bound complex binding site; other site 1278073015048 hinge residues; other site 1278073015049 Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746 1278073015050 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 1278073015051 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1278073015052 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1278073015053 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1278073015054 catalytic residue [active] 1278073015055 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1278073015056 Walker A motif; other site 1278073015057 ATP binding site [chemical binding]; other site 1278073015058 Walker B motif; other site 1278073015059 arginine finger; other site 1278073015060 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1278073015061 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073015062 Walker A motif; other site 1278073015063 ATP binding site [chemical binding]; other site 1278073015064 Walker B motif; other site 1278073015065 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1278073015066 peptide chain release factor 2; Region: prfB; TIGR00020 1278073015067 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073015068 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1278073015069 Walker A motif; other site 1278073015070 ATP binding site [chemical binding]; other site 1278073015071 Walker B motif; other site 1278073015072 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073015073 Walker A motif; other site 1278073015074 ATP binding site [chemical binding]; other site 1278073015075 Walker B motif; other site 1278073015076 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1278073015077 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073015078 Walker A motif; other site 1278073015079 ATP binding site [chemical binding]; other site 1278073015080 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1278073015081 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073015082 Walker A motif; other site 1278073015083 ATP binding site [chemical binding]; other site 1278073015084 Walker B motif; other site 1278073015085 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1278073015086 Beta-lactamase; Region: Beta-lactamase; cl17358 1278073015087 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1278073015088 Putative zinc-finger; Region: zf-HC2; pfam13490 1278073015089 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073015090 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073015091 active site 1278073015092 ATP binding site [chemical binding]; other site 1278073015093 substrate binding site [chemical binding]; other site 1278073015094 activation loop (A-loop); other site 1278073015095 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1278073015096 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1278073015097 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073015098 binding surface 1278073015099 TPR motif; other site 1278073015100 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1278073015101 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1278073015102 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 1278073015103 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1278073015104 Peptidase family M28; Region: Peptidase_M28; pfam04389 1278073015105 metal binding site [ion binding]; metal-binding site 1278073015106 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1278073015107 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1278073015108 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1278073015109 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1278073015110 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1278073015111 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1278073015112 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1278073015113 catalytic loop [active] 1278073015114 iron binding site [ion binding]; other site 1278073015115 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1278073015116 Eukaryotic protein of unknown function (DUF866); Region: DUF866; pfam05907 1278073015117 conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806 1278073015118 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073015119 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073015120 active site 1278073015121 phosphorylation site [posttranslational modification] 1278073015122 intermolecular recognition site; other site 1278073015123 dimerization interface [polypeptide binding]; other site 1278073015124 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073015125 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1278073015126 phosphorylation site [posttranslational modification] 1278073015127 dimer interface [polypeptide binding]; other site 1278073015128 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073015129 ATP binding site [chemical binding]; other site 1278073015130 Mg2+ binding site [ion binding]; other site 1278073015131 G-X-G motif; other site 1278073015132 HEAT repeats; Region: HEAT_2; pfam13646 1278073015133 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1278073015134 dimer interface [polypeptide binding]; other site 1278073015135 substrate binding site [chemical binding]; other site 1278073015136 ATP binding site [chemical binding]; other site 1278073015137 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 1278073015138 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073015139 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1278073015140 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1278073015141 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 1278073015142 calcium binding site 2 [ion binding]; other site 1278073015143 active site 1278073015144 catalytic triad [active] 1278073015145 calcium binding site 1 [ion binding]; other site 1278073015146 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1278073015147 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1278073015148 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1278073015149 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 1278073015150 active site triad [active] 1278073015151 Beta-propeller repeat; Region: SBBP; pfam06739 1278073015152 Beta-propeller repeat; Region: SBBP; pfam06739 1278073015153 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1278073015154 DNA-binding site [nucleotide binding]; DNA binding site 1278073015155 RNA-binding motif; other site 1278073015156 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1278073015157 substrate binding pocket [chemical binding]; other site 1278073015158 substrate-Mg2+ binding site; other site 1278073015159 aspartate-rich region 1; other site 1278073015160 aspartate-rich region 2; other site 1278073015161 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1278073015162 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1278073015163 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1278073015164 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 1278073015165 putative transposase OrfB; Reviewed; Region: PHA02517 1278073015166 HTH-like domain; Region: HTH_21; pfam13276 1278073015167 Integrase core domain; Region: rve; pfam00665 1278073015168 Integrase core domain; Region: rve_3; pfam13683 1278073015169 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1278073015170 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1278073015171 active site 1278073015172 DNA binding site [nucleotide binding] 1278073015173 Int/Topo IB signature motif; other site 1278073015174 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1278073015175 ABC1 family; Region: ABC1; cl17513 1278073015176 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1278073015177 active site 1278073015178 ATP binding site [chemical binding]; other site 1278073015179 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1278073015180 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1278073015181 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1278073015182 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1278073015183 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1278073015184 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1278073015185 putative NADP binding site [chemical binding]; other site 1278073015186 active site 1278073015187 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073015188 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073015189 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1278073015190 active site 1278073015191 Methyltransferase in polyketide synthase (PKS) enzymes; Region: PKS_MT; smart00828 1278073015192 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073015193 S-adenosylmethionine binding site [chemical binding]; other site 1278073015194 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073015195 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073015196 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1278073015197 active site 1278073015198 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1278073015199 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1278073015200 putative NADP binding site [chemical binding]; other site 1278073015201 active site 1278073015202 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073015203 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073015204 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1278073015205 active site 1278073015206 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073015207 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1278073015208 Condensation domain; Region: Condensation; pfam00668 1278073015209 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073015210 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1278073015211 Condensation domain; Region: Condensation; pfam00668 1278073015212 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073015213 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073015214 acyl-activating enzyme (AAE) consensus motif; other site 1278073015215 AMP binding site [chemical binding]; other site 1278073015216 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073015217 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1278073015218 putative FMN binding site [chemical binding]; other site 1278073015219 NADPH bind site [chemical binding]; other site 1278073015220 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1278073015221 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073015222 active site 1278073015223 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1278073015224 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073015225 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1278073015226 active site 1278073015227 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1278073015228 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1278073015229 putative NADP binding site [chemical binding]; other site 1278073015230 active site 1278073015231 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1278073015232 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073015233 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1278073015234 active site 1278073015235 Methyltransferase in polyketide synthase (PKS) enzymes; Region: PKS_MT; smart00828 1278073015236 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073015237 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073015238 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1278073015239 active site 1278073015240 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1278073015241 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073015242 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073015243 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1278073015244 active site 1278073015245 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1278073015246 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1278073015247 putative NADP binding site [chemical binding]; other site 1278073015248 KR domain; Region: KR; pfam08659 1278073015249 active site 1278073015250 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1278073015251 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073015252 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1278073015253 active site 1278073015254 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1278073015255 substrate binding site [chemical binding]; other site 1278073015256 active site 1278073015257 cosubstrate binding site; other site 1278073015258 catalytic site [active] 1278073015259 C-terminal subdomain of the Formyltransferase-like domain found in OzmH-like proteins; Region: FMT_C_OzmH_like; cd08700 1278073015260 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1278073015261 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073015262 S-adenosylmethionine binding site [chemical binding]; other site 1278073015263 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 1278073015264 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1278073015265 acyl-activating enzyme (AAE) consensus motif; other site 1278073015266 AMP binding site [chemical binding]; other site 1278073015267 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073015268 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073015269 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1278073015270 active site 1278073015271 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1278073015272 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1278073015273 putative NADP binding site [chemical binding]; other site 1278073015274 KR domain; Region: KR; pfam08659 1278073015275 active site 1278073015276 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073015277 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1278073015278 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073015279 active site 1278073015280 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1278073015281 putative NADP binding site [chemical binding]; other site 1278073015282 KR domain; Region: KR; pfam08659 1278073015283 active site 1278073015284 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1278073015285 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073015286 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073015287 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1278073015288 active site 1278073015289 Methyltransferase in polyketide synthase (PKS) enzymes; Region: PKS_MT; smart00828 1278073015290 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073015291 S-adenosylmethionine binding site [chemical binding]; other site 1278073015292 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073015293 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073015294 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1278073015295 active site 1278073015296 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1278073015297 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073015298 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1278073015299 active site 1278073015300 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1278073015301 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1278073015302 putative NADP binding site [chemical binding]; other site 1278073015303 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1278073015304 active site 1278073015305 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1278073015306 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073015307 S-adenosylmethionine binding site [chemical binding]; other site 1278073015308 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1278073015309 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1278073015310 Enoylreductase; Region: PKS_ER; smart00829 1278073015311 NAD(P) binding site [chemical binding]; other site 1278073015312 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073015313 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1278073015314 active site 1278073015315 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1278073015316 putative NADP binding site [chemical binding]; other site 1278073015317 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1278073015318 active site 1278073015319 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1278073015320 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073015321 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1278073015322 active site 1278073015323 Methyltransferase in polyketide synthase (PKS) enzymes; Region: PKS_MT; smart00828 1278073015324 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073015325 S-adenosylmethionine binding site [chemical binding]; other site 1278073015326 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073015327 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073015328 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1278073015329 active site 1278073015330 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1278073015331 putative NADP binding site [chemical binding]; other site 1278073015332 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1278073015333 active site 1278073015334 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1278073015335 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1278073015336 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1278073015337 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073015338 active site 1278073015339 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1278073015340 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1278073015341 putative NADP binding site [chemical binding]; other site 1278073015342 active site 1278073015343 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073015344 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073015345 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1278073015346 active site 1278073015347 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073015348 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1278073015349 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1278073015350 ABC1 family; Region: ABC1; cl17513 1278073015351 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1278073015352 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 1278073015353 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1278073015354 metal ion-dependent adhesion site (MIDAS); other site 1278073015355 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1278073015356 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1278073015357 ligand binding site [chemical binding]; other site 1278073015358 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1278073015359 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1278073015360 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1278073015361 Walker A/P-loop; other site 1278073015362 ATP binding site [chemical binding]; other site 1278073015363 Q-loop/lid; other site 1278073015364 ABC transporter signature motif; other site 1278073015365 Walker B; other site 1278073015366 D-loop; other site 1278073015367 H-loop/switch region; other site 1278073015368 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073015369 Walker A/P-loop; other site 1278073015370 ATP binding site [chemical binding]; other site 1278073015371 Q-loop/lid; other site 1278073015372 ABC transporter signature motif; other site 1278073015373 Walker B; other site 1278073015374 D-loop; other site 1278073015375 H-loop/switch region; other site 1278073015376 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1278073015377 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1278073015378 active site 1278073015379 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1278073015380 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1278073015381 acyl-activating enzyme (AAE) consensus motif; other site 1278073015382 AMP binding site [chemical binding]; other site 1278073015383 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1278073015384 Condensation domain; Region: Condensation; pfam00668 1278073015385 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073015386 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073015387 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1278073015388 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 1278073015389 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1278073015390 NAD(P) binding site [chemical binding]; other site 1278073015391 signal recognition particle protein; Provisional; Region: PRK10867 1278073015392 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1278073015393 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1278073015394 P loop; other site 1278073015395 GTP binding site [chemical binding]; other site 1278073015396 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1278073015397 Bacterial Ig-like domain; Region: Big_5; pfam13205 1278073015398 Bacterial Ig-like domain; Region: Big_5; pfam13205 1278073015399 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 1278073015400 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 1278073015401 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 1278073015402 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1278073015403 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073015404 binding surface 1278073015405 TPR motif; other site 1278073015406 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073015407 binding surface 1278073015408 TPR motif; other site 1278073015409 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073015410 binding surface 1278073015411 TPR motif; other site 1278073015412 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073015413 binding surface 1278073015414 TPR motif; other site 1278073015415 Region in Clathrin and VPS; Region: Clathrin; pfam00637 1278073015416 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1278073015417 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1278073015418 phosphopeptide binding site; other site 1278073015419 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073015420 binding surface 1278073015421 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1278073015422 TPR motif; other site 1278073015423 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1278073015424 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073015425 TPR motif; other site 1278073015426 binding surface 1278073015427 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073015428 TPR motif; other site 1278073015429 TPR repeat; Region: TPR_11; pfam13414 1278073015430 binding surface 1278073015431 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073015432 binding surface 1278073015433 TPR motif; other site 1278073015434 hypothetical protein; Validated; Region: PRK08116 1278073015435 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073015436 Walker A motif; other site 1278073015437 ATP binding site [chemical binding]; other site 1278073015438 Walker B motif; other site 1278073015439 CutA1 divalent ion tolerance protein; Region: CutA1; pfam03091 1278073015440 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1278073015441 Clp amino terminal domain; Region: Clp_N; pfam02861 1278073015442 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073015443 Walker A motif; other site 1278073015444 ATP binding site [chemical binding]; other site 1278073015445 Walker B motif; other site 1278073015446 arginine finger; other site 1278073015447 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073015448 Walker A motif; other site 1278073015449 ATP binding site [chemical binding]; other site 1278073015450 Walker B motif; other site 1278073015451 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1278073015452 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 1278073015453 Right handed beta helix region; Region: Beta_helix; pfam13229 1278073015454 aspartate kinase; Reviewed; Region: PRK06635 1278073015455 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 1278073015456 putative catalytic residues [active] 1278073015457 putative nucleotide binding site [chemical binding]; other site 1278073015458 putative aspartate binding site [chemical binding]; other site 1278073015459 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1278073015460 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1278073015461 Walker A/P-loop; other site 1278073015462 ATP binding site [chemical binding]; other site 1278073015463 Q-loop/lid; other site 1278073015464 ABC transporter signature motif; other site 1278073015465 Walker B; other site 1278073015466 D-loop; other site 1278073015467 H-loop/switch region; other site 1278073015468 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 1278073015469 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 1278073015470 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 1278073015471 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 1278073015472 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 1278073015473 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 1278073015474 dimer interface [polypeptide binding]; other site 1278073015475 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 1278073015476 active site 1278073015477 Fe binding site [ion binding]; other site 1278073015478 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 1278073015479 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1278073015480 iron-sulfur cluster [ion binding]; other site 1278073015481 [2Fe-2S] cluster binding site [ion binding]; other site 1278073015482 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073015483 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1278073015484 NAD(P) binding site [chemical binding]; other site 1278073015485 active site 1278073015486 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 1278073015487 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1278073015488 active site 1278073015489 metal binding site [ion binding]; metal-binding site 1278073015490 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 1278073015491 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1278073015492 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073015493 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1278073015494 DNA binding residues [nucleotide binding] 1278073015495 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1278073015496 putative substrate translocation pore; other site 1278073015497 siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718 1278073015498 phosphoglucomutase; Validated; Region: PRK07564 1278073015499 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1278073015500 active site 1278073015501 substrate binding site [chemical binding]; other site 1278073015502 metal binding site [ion binding]; metal-binding site 1278073015503 Predicted membrane protein [Function unknown]; Region: COG4270 1278073015504 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1278073015505 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1278073015506 active site 1278073015507 Ap6A binding site [chemical binding]; other site 1278073015508 nudix motif; other site 1278073015509 metal binding site [ion binding]; metal-binding site 1278073015510 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1278073015511 oligomerisation interface [polypeptide binding]; other site 1278073015512 mobile loop; other site 1278073015513 roof hairpin; other site 1278073015514 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1278073015515 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1278073015516 ring oligomerisation interface [polypeptide binding]; other site 1278073015517 ATP/Mg binding site [chemical binding]; other site 1278073015518 stacking interactions; other site 1278073015519 hinge regions; other site 1278073015520 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1278073015521 GSH binding site [chemical binding]; other site 1278073015522 catalytic residues [active] 1278073015523 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1278073015524 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1278073015525 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1278073015526 phosphopeptide binding site; other site 1278073015527 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1278073015528 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073015529 Walker A motif; other site 1278073015530 ATP binding site [chemical binding]; other site 1278073015531 Walker B motif; other site 1278073015532 arginine finger; other site 1278073015533 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 1278073015534 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1278073015535 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1278073015536 Walker A/P-loop; other site 1278073015537 ATP binding site [chemical binding]; other site 1278073015538 Q-loop/lid; other site 1278073015539 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 1278073015540 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1278073015541 ABC transporter signature motif; other site 1278073015542 Walker B; other site 1278073015543 D-loop; other site 1278073015544 H-loop/switch region; other site 1278073015545 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 1278073015546 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1278073015547 Domain of unknown function DUF21; Region: DUF21; pfam01595 1278073015548 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1278073015549 Transporter associated domain; Region: CorC_HlyC; smart01091 1278073015550 TPR repeat; Region: TPR_11; pfam13414 1278073015551 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073015552 binding surface 1278073015553 TPR motif; other site 1278073015554 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073015555 binding surface 1278073015556 TPR motif; other site 1278073015557 TPR repeat; Region: TPR_11; pfam13414 1278073015558 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073015559 binding surface 1278073015560 TPR motif; other site 1278073015561 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1278073015562 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1278073015563 putative active site [active] 1278073015564 putative metal binding site [ion binding]; other site 1278073015565 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1278073015566 PCRF domain; Region: PCRF; pfam03462 1278073015567 RF-1 domain; Region: RF-1; pfam00472 1278073015568 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1278073015569 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073015570 S-adenosylmethionine binding site [chemical binding]; other site 1278073015571 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1278073015572 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1278073015573 hinge; other site 1278073015574 active site 1278073015575 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 1278073015576 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 1278073015577 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817 1278073015578 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 1278073015579 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 1278073015580 substrate interface [chemical binding]; other site 1278073015581 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 1278073015582 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1278073015583 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1278073015584 phosphopeptide binding site; other site 1278073015585 Prokaryotic RING finger family 1; Region: Prok-RING_1; pfam14446 1278073015586 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1278073015587 Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin...; Region: UBCc; cl00154 1278073015588 E3 interaction residues; other site 1278073015589 Ub thioester intermediate interaction residues; other site 1278073015590 active site cysteine 1278073015591 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1278073015592 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1278073015593 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1278073015594 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1278073015595 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1278073015596 DNA-binding site [nucleotide binding]; DNA binding site 1278073015597 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1278073015598 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1278073015599 homodimer interface [polypeptide binding]; other site 1278073015600 catalytic residue [active] 1278073015601 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1278073015602 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1278073015603 catalytic residue [active] 1278073015604 Protein tyrosine kinase; Region: Pkinase_Tyr; pfam07714 1278073015605 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073015606 active site 1278073015607 ATP binding site [chemical binding]; other site 1278073015608 substrate binding site [chemical binding]; other site 1278073015609 activation loop (A-loop); other site 1278073015610 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1278073015611 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1278073015612 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073015613 binding surface 1278073015614 TPR motif; other site 1278073015615 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1278073015616 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1278073015617 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1278073015618 haloalkane dehalogenase; Provisional; Region: PRK03592 1278073015619 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1278073015620 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073015621 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1278073015622 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 1278073015623 Dual-action HEIGH metallo-peptidase; Region: Peptidase_M57; pfam12388 1278073015624 LCCL domain; Region: LCCL; pfam03815 1278073015625 LCCL domain; Region: LCCL; pfam03815 1278073015626 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1278073015627 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1278073015628 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1278073015629 putative effector binding pocket; other site 1278073015630 dimerization interface [polypeptide binding]; other site 1278073015631 short chain dehydrogenase; Provisional; Region: PRK07041 1278073015632 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073015633 NAD(P) binding site [chemical binding]; other site 1278073015634 active site 1278073015635 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1278073015636 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1278073015637 Cupin domain; Region: Cupin_2; cl17218 1278073015638 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1278073015639 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1278073015640 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1278073015641 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1278073015642 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073015643 NACHT domain; Region: NACHT; pfam05729 1278073015644 Walker A motif; other site 1278073015645 ATP binding site [chemical binding]; other site 1278073015646 Walker B motif; other site 1278073015647 arginine finger; other site 1278073015648 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1278073015649 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1278073015650 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1278073015651 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1278073015652 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1278073015653 structural tetrad; other site 1278073015654 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1278073015655 structural tetrad; other site 1278073015656 WD40 repeats; Region: WD40; smart00320 1278073015657 Helix-turn-helix domain; Region: HTH_28; pfam13518 1278073015658 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1278073015659 Fungalysin metallopeptidase (M36); Region: Peptidase_M36; pfam02128 1278073015660 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 1278073015661 Zn binding site [ion binding]; other site 1278073015662 Patatin-like phospholipase; Region: Patatin; pfam01734 1278073015663 active site 1278073015664 nucleophile elbow; other site 1278073015665 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1278073015666 Predicted membrane protein [Function unknown]; Region: COG2261 1278073015667 Chalcone-flavanone isomerase; Region: Chalcone; cl03589 1278073015668 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 1278073015669 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1278073015670 catalytic residue [active] 1278073015671 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1278073015672 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073015673 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1278073015674 DNA binding residues [nucleotide binding] 1278073015675 Caspase domain; Region: Peptidase_C14; pfam00656 1278073015676 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073015677 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 1278073015678 hypothetical protein; Provisional; Region: PRK05409 1278073015679 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1278073015680 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1278073015681 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1278073015682 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1278073015683 CoenzymeA binding site [chemical binding]; other site 1278073015684 subunit interaction site [polypeptide binding]; other site 1278073015685 PHB binding site; other site 1278073015686 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1278073015687 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1278073015688 dimer interface [polypeptide binding]; other site 1278073015689 active site 1278073015690 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1278073015691 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1278073015692 non-specific DNA binding site [nucleotide binding]; other site 1278073015693 salt bridge; other site 1278073015694 sequence-specific DNA binding site [nucleotide binding]; other site 1278073015695 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 1278073015696 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1278073015697 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 1278073015698 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1278073015699 binding surface 1278073015700 TPR motif; other site 1278073015701 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1278073015702 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1278073015703 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1278073015704 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1278073015705 interface (dimer of trimers) [polypeptide binding]; other site 1278073015706 Substrate-binding/catalytic site; other site 1278073015707 Zn-binding sites [ion binding]; other site 1278073015708 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 1278073015709 Thioredoxin; Region: Thioredoxin_4; pfam13462 1278073015710 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1278073015711 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1278073015712 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1278073015713 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1278073015714 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073015715 Walker A motif; other site 1278073015716 ATP binding site [chemical binding]; other site 1278073015717 Walker B motif; other site 1278073015718 arginine finger; other site 1278073015719 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1278073015720 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1278073015721 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1278073015722 RuvA N terminal domain; Region: RuvA_N; pfam01330 1278073015723 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1278073015724 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 1278073015725 active site 1278073015726 putative DNA-binding cleft [nucleotide binding]; other site 1278073015727 dimer interface [polypeptide binding]; other site 1278073015728 hypothetical protein; Validated; Region: PRK00110 1278073015729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073015730 active site 1278073015731 phosphorylation site [posttranslational modification] 1278073015732 intermolecular recognition site; other site 1278073015733 dimerization interface [polypeptide binding]; other site 1278073015734 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1278073015735 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073015736 active site 1278073015737 phosphorylation site [posttranslational modification] 1278073015738 intermolecular recognition site; other site 1278073015739 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073015740 Walker A motif; other site 1278073015741 ATP binding site [chemical binding]; other site 1278073015742 Walker B motif; other site 1278073015743 arginine finger; other site 1278073015744 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1278073015745 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 1278073015746 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 1278073015747 putative active site [active] 1278073015748 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1278073015749 hypothetical protein; Reviewed; Region: PRK09588 1278073015750 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 1278073015751 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 1278073015752 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073015753 Walker A motif; other site 1278073015754 ATP binding site [chemical binding]; other site 1278073015755 Walker B motif; other site 1278073015756 arginine finger; other site 1278073015757 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1278073015758 active site 1278073015759 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 1278073015760 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073015761 binding surface 1278073015762 TPR motif; other site 1278073015763 TPR repeat; Region: TPR_11; pfam13414 1278073015764 CHAT domain; Region: CHAT; cl17868 1278073015765 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1278073015766 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073015767 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1278073015768 DNA binding residues [nucleotide binding] 1278073015769 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1278073015770 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1278073015771 NAD(P) binding site [chemical binding]; other site 1278073015772 CHAT domain; Region: CHAT; cl17868 1278073015773 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 1278073015774 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073015775 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1278073015776 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073015777 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073015778 dimer interface [polypeptide binding]; other site 1278073015779 phosphorylation site [posttranslational modification] 1278073015780 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073015781 ATP binding site [chemical binding]; other site 1278073015782 Mg2+ binding site [ion binding]; other site 1278073015783 G-X-G motif; other site 1278073015784 EamA-like transporter family; Region: EamA; pfam00892 1278073015785 DTW domain; Region: DTW; cl01221 1278073015786 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1278073015787 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 1278073015788 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1278073015789 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1278073015790 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1278073015791 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cd02106 1278073015792 cysteine desulfurase; Provisional; Region: PRK14012 1278073015793 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1278073015794 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1278073015795 catalytic residue [active] 1278073015796 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1278073015797 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1278073015798 trimerization site [polypeptide binding]; other site 1278073015799 active site 1278073015800 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1278073015801 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1278073015802 HSP70 interaction site [polypeptide binding]; other site 1278073015803 chaperone protein HscA; Provisional; Region: hscA; PRK05183 1278073015804 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 1278073015805 nucleotide binding site [chemical binding]; other site 1278073015806 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1278073015807 SBD interface [polypeptide binding]; other site 1278073015808 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1278073015809 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1278073015810 catalytic loop [active] 1278073015811 iron binding site [ion binding]; other site 1278073015812 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1278073015813 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1278073015814 Surface antigen; Region: Bac_surface_Ag; pfam01103 1278073015815 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 1278073015816 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1278073015817 diphosphomevalonate decarboxylase; Region: PLN02407 1278073015818 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 1278073015819 mevalonate kinase; Region: mevalon_kin; TIGR00549 1278073015820 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1278073015821 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 1278073015822 homodimer interface [polypeptide binding]; other site 1278073015823 catalytic residues [active] 1278073015824 NAD binding site [chemical binding]; other site 1278073015825 substrate binding pocket [chemical binding]; other site 1278073015826 flexible flap; other site 1278073015827 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1278073015828 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1278073015829 homotetramer interface [polypeptide binding]; other site 1278073015830 FMN binding site [chemical binding]; other site 1278073015831 homodimer contacts [polypeptide binding]; other site 1278073015832 putative active site [active] 1278073015833 putative substrate binding site [chemical binding]; other site 1278073015834 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 1278073015835 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1278073015836 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1278073015837 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1278073015838 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1278073015839 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1278073015840 Imelysin; Region: Peptidase_M75; pfam09375 1278073015841 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 1278073015842 Peptidase family M48; Region: Peptidase_M48; cl12018 1278073015843 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 1278073015844 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1278073015845 MarR family; Region: MarR; pfam01047 1278073015846 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 1278073015847 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1278073015848 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1278073015849 HlyD family secretion protein; Region: HlyD_3; pfam13437 1278073015850 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1278073015851 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1278073015852 glutaminase; Provisional; Region: PRK00971 1278073015853 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3826 1278073015854 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1278073015855 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1278073015856 Ion transport protein; Region: Ion_trans; pfam00520 1278073015857 Ion channel; Region: Ion_trans_2; pfam07885 1278073015858 Double zinc ribbon; Region: DZR; pfam12773 1278073015859 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1278073015860 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1278073015861 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1278073015862 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1278073015863 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1278073015864 active site 1278073015865 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1278073015866 classical (c) SDRs; Region: SDR_c; cd05233 1278073015867 NAD(P) binding site [chemical binding]; other site 1278073015868 active site 1278073015869 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1278073015870 active site 1278073015871 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1278073015872 Beta-lactamase; Region: Beta-lactamase; pfam00144 1278073015873 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1278073015874 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1278073015875 dimerization interface [polypeptide binding]; other site 1278073015876 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073015877 dimer interface [polypeptide binding]; other site 1278073015878 phosphorylation site [posttranslational modification] 1278073015879 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073015880 ATP binding site [chemical binding]; other site 1278073015881 Mg2+ binding site [ion binding]; other site 1278073015882 G-X-G motif; other site 1278073015883 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1278073015884 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1278073015885 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1278073015886 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1278073015887 binding surface 1278073015888 TPR motif; other site 1278073015889 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073015890 TPR motif; other site 1278073015891 binding surface 1278073015892 Protein of unknown function (DUF779); Region: DUF779; pfam05610 1278073015893 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1278073015894 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1278073015895 NAD(P) binding site [chemical binding]; other site 1278073015896 catalytic residues [active] 1278073015897 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 1278073015898 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073015899 Walker A motif; other site 1278073015900 ATP binding site [chemical binding]; other site 1278073015901 Walker B motif; other site 1278073015902 arginine finger; other site 1278073015903 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1278073015904 Ferritin-like domain; Region: Ferritin; pfam00210 1278073015905 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1278073015906 dinuclear metal binding motif [ion binding]; other site 1278073015907 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1278073015908 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1278073015909 putative di-iron ligands [ion binding]; other site 1278073015910 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1278073015911 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073015912 active site 1278073015913 phosphorylation site [posttranslational modification] 1278073015914 intermolecular recognition site; other site 1278073015915 dimerization interface [polypeptide binding]; other site 1278073015916 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 1278073015917 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073015918 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073015919 active site 1278073015920 phosphorylation site [posttranslational modification] 1278073015921 intermolecular recognition site; other site 1278073015922 dimerization interface [polypeptide binding]; other site 1278073015923 GAF domain; Region: GAF_3; pfam13492 1278073015924 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1278073015925 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1278073015926 metal binding site [ion binding]; metal-binding site 1278073015927 active site 1278073015928 I-site; other site 1278073015929 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1278073015930 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1278073015931 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1278073015932 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1278073015933 ribonucleoside--diphosphate reductase large subunit; Region: PLN02437 1278073015934 ATP cone domain; Region: ATP-cone; pfam03477 1278073015935 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1278073015936 active site 1278073015937 dimer interface [polypeptide binding]; other site 1278073015938 catalytic residues [active] 1278073015939 effector binding site; other site 1278073015940 R2 peptide binding site; other site 1278073015941 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1278073015942 dimer interface [polypeptide binding]; other site 1278073015943 putative radical transfer pathway; other site 1278073015944 diiron center [ion binding]; other site 1278073015945 tyrosyl radical; other site 1278073015946 Family description; Region: VCBS; pfam13517 1278073015947 Insecticide toxin TcdB middle/N-terminal region; Region: TcdB_toxin_midN; pfam12256 1278073015948 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1278073015949 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1278073015950 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1278073015951 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1278073015952 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1278073015953 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 1278073015954 amphipathic channel; other site 1278073015955 Asn-Pro-Ala signature motifs; other site 1278073015956 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1278073015957 active site 1278073015958 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1278073015959 active site 1278073015960 thymidine kinase; Provisional; Region: PRK04296 1278073015961 regulatory protein SpoVG; Reviewed; Region: PRK13259 1278073015962 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1278073015963 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1278073015964 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1278073015965 active site 1278073015966 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1278073015967 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 1278073015968 5S rRNA interface [nucleotide binding]; other site 1278073015969 CTC domain interface [polypeptide binding]; other site 1278073015970 L16 interface [polypeptide binding]; other site 1278073015971 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1278073015972 putative active site [active] 1278073015973 catalytic residue [active] 1278073015974 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 1278073015975 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1278073015976 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1278073015977 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1278073015978 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1278073015979 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1278073015980 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 1278073015981 Histidine kinase; Region: His_kinase; pfam06580 1278073015982 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073015983 Mg2+ binding site [ion binding]; other site 1278073015984 G-X-G motif; other site 1278073015985 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 1278073015986 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073015987 active site 1278073015988 phosphorylation site [posttranslational modification] 1278073015989 intermolecular recognition site; other site 1278073015990 dimerization interface [polypeptide binding]; other site 1278073015991 LytTr DNA-binding domain; Region: LytTR; smart00850 1278073015992 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1278073015993 replicative DNA helicase; Region: DnaB; TIGR00665 1278073015994 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1278073015995 Walker A motif; other site 1278073015996 ATP binding site [chemical binding]; other site 1278073015997 Walker B motif; other site 1278073015998 DNA binding loops [nucleotide binding] 1278073015999 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1278073016000 substrate binding site [chemical binding]; other site 1278073016001 ATP binding site [chemical binding]; other site 1278073016002 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1278073016003 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1278073016004 catalytic triad [active] 1278073016005 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1278073016006 active site 1278073016007 thiamine phosphate binding site [chemical binding]; other site 1278073016008 pyrophosphate binding site [ion binding]; other site 1278073016009 Domain of unknown function (DUF1844); Region: DUF1844; pfam08899 1278073016010 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1278073016011 Clp amino terminal domain; Region: Clp_N; pfam02861 1278073016012 Clp amino terminal domain; Region: Clp_N; pfam02861 1278073016013 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073016014 Walker A motif; other site 1278073016015 ATP binding site [chemical binding]; other site 1278073016016 Walker B motif; other site 1278073016017 arginine finger; other site 1278073016018 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073016019 Walker A motif; other site 1278073016020 ATP binding site [chemical binding]; other site 1278073016021 Walker B motif; other site 1278073016022 arginine finger; other site 1278073016023 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1278073016024 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 1278073016025 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1278073016026 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1278073016027 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1278073016028 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1278073016029 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073016030 NAD(P) binding site [chemical binding]; other site 1278073016031 active site 1278073016032 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1278073016033 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 1278073016034 metal binding site [ion binding]; metal-binding site 1278073016035 putative dimer interface [polypeptide binding]; other site 1278073016036 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 1278073016037 Predicted transcriptional regulator [Transcription]; Region: COG3655 1278073016038 non-specific DNA binding site [nucleotide binding]; other site 1278073016039 salt bridge; other site 1278073016040 sequence-specific DNA binding site [nucleotide binding]; other site 1278073016041 Erythromycin esterase; Region: Erythro_esteras; cl17110 1278073016042 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 1278073016043 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073016044 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073016045 dimer interface [polypeptide binding]; other site 1278073016046 phosphorylation site [posttranslational modification] 1278073016047 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073016048 ATP binding site [chemical binding]; other site 1278073016049 Mg2+ binding site [ion binding]; other site 1278073016050 G-X-G motif; other site 1278073016051 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1278073016052 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073016053 active site 1278073016054 phosphorylation site [posttranslational modification] 1278073016055 intermolecular recognition site; other site 1278073016056 dimerization interface [polypeptide binding]; other site 1278073016057 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1278073016058 DNA binding site [nucleotide binding] 1278073016059 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1278073016060 metal ion-dependent adhesion site (MIDAS); other site 1278073016061 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1278073016062 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1278073016063 N-acetylornithine carbamoyltransferase; Reviewed; Region: PRK04523 1278073016064 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1278073016065 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1278073016066 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1278073016067 nucleotide binding site [chemical binding]; other site 1278073016068 substrate binding site [chemical binding]; other site 1278073016069 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 1278073016070 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1278073016071 metal binding site [ion binding]; metal-binding site 1278073016072 Lyase; Region: Lyase_1; pfam00206 1278073016073 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1278073016074 active sites [active] 1278073016075 tetramer interface [polypeptide binding]; other site 1278073016076 argininosuccinate synthase; Provisional; Region: PRK13820 1278073016077 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1278073016078 Ligand Binding Site [chemical binding]; other site 1278073016079 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1278073016080 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1278073016081 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1278073016082 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 1278073016083 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1278073016084 RNA polymerase II transcription mediator complex subunit 9; Region: Med9; pfam07544 1278073016085 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1278073016086 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1278073016087 dimerization interface 3.5A [polypeptide binding]; other site 1278073016088 active site 1278073016089 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1278073016090 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073016091 active site 1278073016092 ATP binding site [chemical binding]; other site 1278073016093 substrate binding site [chemical binding]; other site 1278073016094 activation loop (A-loop); other site 1278073016095 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1278073016096 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1278073016097 putative RNA binding site [nucleotide binding]; other site 1278073016098 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073016099 S-adenosylmethionine binding site [chemical binding]; other site 1278073016100 putative selenium metabolism protein SsnA; Region: Se_ssnA; TIGR03314 1278073016101 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1278073016102 active site 1278073016103 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 1278073016104 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1278073016105 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1278073016106 DNA binding residues [nucleotide binding] 1278073016107 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1278073016108 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073016109 S-adenosylmethionine binding site [chemical binding]; other site 1278073016110 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073016111 S-adenosylmethionine binding site [chemical binding]; other site 1278073016112 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073016113 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073016114 dimer interface [polypeptide binding]; other site 1278073016115 phosphorylation site [posttranslational modification] 1278073016116 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1278073016117 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1278073016118 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073016119 active site 1278073016120 phosphorylation site [posttranslational modification] 1278073016121 intermolecular recognition site; other site 1278073016122 dimerization interface [polypeptide binding]; other site 1278073016123 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073016124 Walker A motif; other site 1278073016125 ATP binding site [chemical binding]; other site 1278073016126 Walker B motif; other site 1278073016127 arginine finger; other site 1278073016128 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1278073016129 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1278073016130 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 1278073016131 ligand binding site [chemical binding]; other site 1278073016132 flexible hinge region; other site 1278073016133 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1278073016134 putative switch regulator; other site 1278073016135 non-specific DNA interactions [nucleotide binding]; other site 1278073016136 DNA binding site [nucleotide binding] 1278073016137 sequence specific DNA binding site [nucleotide binding]; other site 1278073016138 putative cAMP binding site [chemical binding]; other site 1278073016139 phenylalanine 4-monooxygenase; Provisional; Region: PRK14056 1278073016140 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 1278073016141 cofactor binding site; other site 1278073016142 metal binding site [ion binding]; metal-binding site 1278073016143 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1278073016144 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1278073016145 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1278073016146 dimerization interface [polypeptide binding]; other site 1278073016147 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 1278073016148 Sulfatase; Region: Sulfatase; cl17466 1278073016149 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1278073016150 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1278073016151 active site 1278073016152 metal binding site [ion binding]; metal-binding site 1278073016153 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 1278073016154 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 1278073016155 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1278073016156 active site 1278073016157 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1278073016158 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1278073016159 active site 1278073016160 active site 1278073016161 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1278073016162 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1278073016163 active site 1278073016164 active site 1278073016165 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1278073016166 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1278073016167 active site 1278073016168 active site 1278073016169 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1278073016170 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1278073016171 active site 1278073016172 active site 1278073016173 MutS domain III; Region: MutS_III; pfam05192 1278073016174 ATP-binding cassette domain of MutS-like homolog; Region: ABC_MutS-like; cd03283 1278073016175 Walker A/P-loop; other site 1278073016176 ATP binding site [chemical binding]; other site 1278073016177 Q-loop/lid; other site 1278073016178 ABC transporter signature motif; other site 1278073016179 Walker B; other site 1278073016180 D-loop; other site 1278073016181 H-loop/switch region; other site 1278073016182 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1278073016183 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 1278073016184 dimer interface [polypeptide binding]; other site 1278073016185 active site 1278073016186 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1278073016187 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1278073016188 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1278073016189 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1278073016190 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1278073016191 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1278073016192 substrate binding site [chemical binding]; other site 1278073016193 oxyanion hole (OAH) forming residues; other site 1278073016194 trimer interface [polypeptide binding]; other site 1278073016195 leukotriene A-4 hydrolase/aminopeptidase; Region: leuko_A4_hydro; TIGR02411 1278073016196 Peptidase M1 family contains leukotriene A4 hydrolase; Region: M1_LTA4H; cd09599 1278073016197 active site 1278073016198 Zn binding site [ion binding]; other site 1278073016199 Leukotriene A4 hydrolase, C-terminal; Region: Leuk-A4-hydro_C; pfam09127 1278073016200 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1278073016201 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1278073016202 DNA methylase; Region: N6_N4_Mtase; pfam01555 1278073016203 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1278073016204 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1278073016205 active site 1278073016206 metal binding site [ion binding]; metal-binding site 1278073016207 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1278073016208 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1278073016209 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 1278073016210 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073016211 S-adenosylmethionine binding site [chemical binding]; other site 1278073016212 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1278073016213 TPR repeat; Region: TPR_11; pfam13414 1278073016214 TPR motif; other site 1278073016215 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1278073016216 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073016217 active site 1278073016218 phosphorylation site [posttranslational modification] 1278073016219 intermolecular recognition site; other site 1278073016220 dimerization interface [polypeptide binding]; other site 1278073016221 CheB methylesterase; Region: CheB_methylest; pfam01339 1278073016222 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1278073016223 putative binding surface; other site 1278073016224 active site 1278073016225 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073016226 ATP binding site [chemical binding]; other site 1278073016227 Mg2+ binding site [ion binding]; other site 1278073016228 G-X-G motif; other site 1278073016229 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1278073016230 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073016231 active site 1278073016232 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073016233 phosphorylation site [posttranslational modification] 1278073016234 intermolecular recognition site; other site 1278073016235 dimerization interface [polypeptide binding]; other site 1278073016236 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1278073016237 dimerization interface [polypeptide binding]; other site 1278073016238 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1278073016239 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1278073016240 dimer interface [polypeptide binding]; other site 1278073016241 putative CheW interface [polypeptide binding]; other site 1278073016242 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1278073016243 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1278073016244 dimer interface [polypeptide binding]; other site 1278073016245 putative CheW interface [polypeptide binding]; other site 1278073016246 CheW-like domain; Region: CheW; pfam01584 1278073016247 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1278073016248 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1278073016249 ligand binding site [chemical binding]; other site 1278073016250 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1278073016251 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073016252 active site 1278073016253 phosphorylation site [posttranslational modification] 1278073016254 intermolecular recognition site; other site 1278073016255 dimerization interface [polypeptide binding]; other site 1278073016256 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073016257 Walker A motif; other site 1278073016258 ATP binding site [chemical binding]; other site 1278073016259 Walker B motif; other site 1278073016260 arginine finger; other site 1278073016261 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1278073016262 Terminase small subunit; Region: Terminase_2; cl01513 1278073016263 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1278073016264 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1278073016265 AzlC protein; Region: AzlC; pfam03591 1278073016266 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1278073016267 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1278073016268 non-specific DNA binding site [nucleotide binding]; other site 1278073016269 salt bridge; other site 1278073016270 sequence-specific DNA binding site [nucleotide binding]; other site 1278073016271 Cupin domain; Region: Cupin_2; cl17218 1278073016272 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 1278073016273 MreB/Mbl protein; Region: MreB_Mbl; pfam06723 1278073016274 nucleotide binding site [chemical binding]; other site 1278073016275 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1278073016276 SBD interface [polypeptide binding]; other site 1278073016277 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 1278073016278 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1278073016279 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 1278073016280 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073016281 active site 1278073016282 phosphorylation site [posttranslational modification] 1278073016283 intermolecular recognition site; other site 1278073016284 dimerization interface [polypeptide binding]; other site 1278073016285 LytTr DNA-binding domain; Region: LytTR; smart00850 1278073016286 Histidine kinase; Region: His_kinase; pfam06580 1278073016287 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073016288 ATP binding site [chemical binding]; other site 1278073016289 Mg2+ binding site [ion binding]; other site 1278073016290 G-X-G motif; other site 1278073016291 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1278073016292 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1278073016293 active site 1278073016294 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 1278073016295 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1278073016296 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1278073016297 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1278073016298 ligand binding site [chemical binding]; other site 1278073016299 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1278073016300 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1278073016301 Predicted esterase [General function prediction only]; Region: COG0400 1278073016302 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1278073016303 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1278073016304 putative catalytic site [active] 1278073016305 putative phosphate binding site [ion binding]; other site 1278073016306 active site 1278073016307 DNA binding site [nucleotide binding] 1278073016308 metal binding site A [ion binding]; metal-binding site 1278073016309 putative AP binding site [nucleotide binding]; other site 1278073016310 putative metal binding site B [ion binding]; other site 1278073016311 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073016312 TPR motif; other site 1278073016313 TPR repeat; Region: TPR_11; pfam13414 1278073016314 binding surface 1278073016315 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073016316 TPR motif; other site 1278073016317 binding surface 1278073016318 Transglycosylase; Region: Transgly; pfam00912 1278073016319 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1278073016320 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1278073016321 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1278073016322 dimerization interface [polypeptide binding]; other site 1278073016323 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1278073016324 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073016325 dimer interface [polypeptide binding]; other site 1278073016326 phosphorylation site [posttranslational modification] 1278073016327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073016328 ATP binding site [chemical binding]; other site 1278073016329 Mg2+ binding site [ion binding]; other site 1278073016330 G-X-G motif; other site 1278073016331 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 1278073016332 30S subunit binding site; other site 1278073016333 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073016334 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073016335 active site 1278073016336 phosphorylation site [posttranslational modification] 1278073016337 intermolecular recognition site; other site 1278073016338 dimerization interface [polypeptide binding]; other site 1278073016339 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 1278073016340 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 1278073016341 HEAT repeats; Region: HEAT_2; pfam13646 1278073016342 HEAT repeats; Region: HEAT_2; pfam13646 1278073016343 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1278073016344 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1278073016345 ligand binding site [chemical binding]; other site 1278073016346 tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142 1278073016347 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 1278073016348 Permutation of conserved domain; other site 1278073016349 active site 1278073016350 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1278073016351 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 1278073016352 Thioredoxin; Region: Thioredoxin_4; pfam13462 1278073016353 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1278073016354 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1278073016355 homodimer interface [polypeptide binding]; other site 1278073016356 active site 1278073016357 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1278073016358 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1278073016359 phosphopeptide binding site; other site 1278073016360 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1278073016361 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1278073016362 metal binding site [ion binding]; metal-binding site 1278073016363 active site 1278073016364 I-site; other site 1278073016365 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1278073016366 Yqey-like protein; Region: YqeY; pfam09424 1278073016367 DNA primase, catalytic core; Region: dnaG; TIGR01391 1278073016368 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1278073016369 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1278073016370 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1278073016371 active site 1278073016372 metal binding site [ion binding]; metal-binding site 1278073016373 interdomain interaction site; other site 1278073016374 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1278073016375 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1278073016376 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1278073016377 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1278073016378 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073016379 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1278073016380 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1278073016381 DNA binding residues [nucleotide binding] 1278073016382 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1278073016383 DNA binding site [nucleotide binding] 1278073016384 active site 1278073016385 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 1278073016386 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1278073016387 Serine hydrolase (FSH1); Region: FSH1; pfam03959 1278073016388 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1278073016389 Zn binding site [ion binding]; other site 1278073016390 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 1278073016391 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 1278073016392 Family description; Region: VCBS; pfam13517 1278073016393 Family description; Region: VCBS; pfam13517 1278073016394 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1278073016395 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1278073016396 active site 1278073016397 metal binding site [ion binding]; metal-binding site 1278073016398 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1278073016399 Yersinia/Haemophilus virulence surface antigen; Region: Peptidase_C58; cl04145 1278073016400 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 1278073016401 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 1278073016402 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1278073016403 PA_M28_1_1: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 1. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_1; cd04820 1278073016404 PA/protease or protease-like domain interface [polypeptide binding]; other site 1278073016405 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_2; cd05661 1278073016406 Peptidase family M28; Region: Peptidase_M28; pfam04389 1278073016407 metal binding site [ion binding]; metal-binding site 1278073016408 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1278073016409 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1278073016410 Cl- selectivity filter; other site 1278073016411 Cl- binding residues [ion binding]; other site 1278073016412 pore gating glutamate residue; other site 1278073016413 dimer interface [polypeptide binding]; other site 1278073016414 FOG: CBS domain [General function prediction only]; Region: COG0517 1278073016415 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 1278073016416 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1278073016417 MarR family; Region: MarR_2; pfam12802 1278073016418 Predicted transcriptional regulators [Transcription]; Region: COG1733 1278073016419 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1278073016420 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1278073016421 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1278073016422 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 1278073016423 Ribosomal_L32_L32e: L32 is a protein from the large subunit that contains a surface-exposed globular domain and a finger-like projection that extends into the RNA core to stabilize the tertiary structure. L32 does not appear to play a role in forming the...; Region: Ribosomal_L32_L32e; cl00748 1278073016424 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1278073016425 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073016426 TPR motif; other site 1278073016427 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1278073016428 active site 1278073016429 DinB family; Region: DinB; cl17821 1278073016430 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1278073016431 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1278073016432 active site 1278073016433 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 1278073016434 putative hydrophobic ligand binding site [chemical binding]; other site 1278073016435 protein interface [polypeptide binding]; other site 1278073016436 gate; other site 1278073016437 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1278073016438 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1278073016439 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1278073016440 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073016441 binding surface 1278073016442 TPR motif; other site 1278073016443 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1278073016444 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073016445 TPR repeat; Region: TPR_11; pfam13414 1278073016446 binding surface 1278073016447 TPR motif; other site 1278073016448 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1278073016449 Beta-lactamase; Region: Beta-lactamase; pfam00144 1278073016450 Beta-lactamase; Region: Beta-lactamase; pfam00144 1278073016451 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1278073016452 Predicted membrane protein (DUF2306); Region: DUF2306; pfam10067 1278073016453 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073016454 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073016455 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073016456 putative lipoprotein, rSAM/lipoprotein system; Region: lipo_with_rSAM; TIGR04134 1278073016457 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073016458 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073016459 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 1278073016460 short chain dehydrogenase; Provisional; Region: PRK06172 1278073016461 classical (c) SDRs; Region: SDR_c; cd05233 1278073016462 NAD(P) binding site [chemical binding]; other site 1278073016463 active site 1278073016464 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1278073016465 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1278073016466 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1278073016467 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1278073016468 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1278073016469 Coenzyme A binding pocket [chemical binding]; other site 1278073016470 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1278073016471 dinuclear metal binding motif [ion binding]; other site 1278073016472 Fibronectin type 3 domain; Region: FN3; smart00060 1278073016473 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1278073016474 Interdomain contacts; other site 1278073016475 Cytokine receptor motif; other site 1278073016476 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1278073016477 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1278073016478 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1278073016479 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1278073016480 active site 1278073016481 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1278073016482 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1278073016483 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1278073016484 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 1278073016485 short chain dehydrogenase; Provisional; Region: PRK07774 1278073016486 classical (c) SDRs; Region: SDR_c; cd05233 1278073016487 NAD(P) binding site [chemical binding]; other site 1278073016488 active site 1278073016489 O-methyltransferase; Region: Methyltransf_2; pfam00891 1278073016490 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1278073016491 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 1278073016492 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073016493 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1278073016494 DNA binding residues [nucleotide binding] 1278073016495 NAD-dependent deacetylase; Provisional; Region: PRK00481 1278073016496 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 1278073016497 NAD+ binding site [chemical binding]; other site 1278073016498 substrate binding site [chemical binding]; other site 1278073016499 Zn binding site [ion binding]; other site 1278073016500 acyl-CoA synthetase; Validated; Region: PRK08308 1278073016501 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1278073016502 putative active site [active] 1278073016503 catalytic site [active] 1278073016504 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1278073016505 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1278073016506 ATP binding site [chemical binding]; other site 1278073016507 putative Mg++ binding site [ion binding]; other site 1278073016508 nucleotide binding region [chemical binding]; other site 1278073016509 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 1278073016510 ATP-binding site [chemical binding]; other site 1278073016511 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 1278073016512 Domain of unknown function (DUF4375); Region: DUF4375; pfam14300 1278073016513 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1278073016514 Isochorismatase family; Region: Isochorismatase; pfam00857 1278073016515 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1278073016516 catalytic triad [active] 1278073016517 conserved cis-peptide bond; other site 1278073016518 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1278073016519 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 1278073016520 conserved cys residue [active] 1278073016521 Putative peptidase family; Region: Metallopep; pfam12044 1278073016522 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1278073016523 binding surface 1278073016524 TPR motif; other site 1278073016525 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1278073016526 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1278073016527 active site 1278073016528 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1278073016529 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1278073016530 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073016531 S-adenosylmethionine binding site [chemical binding]; other site 1278073016532 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1278073016533 Beta-lactamase; Region: Beta-lactamase; pfam00144 1278073016534 MEKHLA domain; Region: MEKHLA; pfam08670 1278073016535 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1278073016536 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1278073016537 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1278073016538 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1278073016539 TPP-binding site [chemical binding]; other site 1278073016540 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1278073016541 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1278073016542 Coenzyme A binding pocket [chemical binding]; other site 1278073016543 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073016544 S-adenosylmethionine binding site [chemical binding]; other site 1278073016545 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073016546 S-adenosylmethionine binding site [chemical binding]; other site 1278073016547 Beta-lactamase; Region: Beta-lactamase; pfam00144 1278073016548 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1278073016549 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 1278073016550 WGR domain; Region: WGR; cl01581 1278073016551 Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279 1278073016552 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1278073016553 active site 1278073016554 active site 1278073016555 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1278073016556 homotrimer interaction site [polypeptide binding]; other site 1278073016557 putative active site [active] 1278073016558 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1278073016559 TAP-like protein; Region: Abhydrolase_4; pfam08386 1278073016560 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 1278073016561 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 1278073016562 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 1278073016563 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 1278073016564 choice-of-anchor C domain; Region: choice_anch_C; TIGR04362 1278073016565 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1278073016566 Amidinotransferase; Region: Amidinotransf; cl12043 1278073016567 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073016568 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073016569 active site 1278073016570 ATP binding site [chemical binding]; other site 1278073016571 substrate binding site [chemical binding]; other site 1278073016572 activation loop (A-loop); other site 1278073016573 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1278073016574 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 1278073016575 CotH protein; Region: CotH; pfam08757 1278073016576 OpgC protein; Region: OpgC_C; cl17858 1278073016577 Fn3 associated; Region: Fn3_assoc; pfam13287 1278073016578 CotH protein; Region: CotH; pfam08757 1278073016579 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1278073016580 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 1278073016581 putative active site [active] 1278073016582 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 1278073016583 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 1278073016584 Cytochrome c552; Region: Cytochrom_C552; pfam02335 1278073016585 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1278073016586 repeat-companion domain TIGR02996; Region: rpt_mate_G_obs 1278073016587 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 1278073016588 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1278073016589 putative active site [active] 1278073016590 putative NTP binding site [chemical binding]; other site 1278073016591 putative nucleic acid binding site [nucleotide binding]; other site 1278073016592 HEAT repeats; Region: HEAT_2; pfam13646 1278073016593 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1278073016594 active site 1278073016595 catalytic tetrad [active] 1278073016596 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1278073016597 amidase catalytic site [active] 1278073016598 Zn binding residues [ion binding]; other site 1278073016599 substrate binding site [chemical binding]; other site 1278073016600 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1278073016601 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1278073016602 Peptidase family M23; Region: Peptidase_M23; pfam01551 1278073016603 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1278073016604 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1278073016605 PA_M28_1_1: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 1. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_1; cd04820 1278073016606 PA/protease or protease-like domain interface [polypeptide binding]; other site 1278073016607 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_2; cd05661 1278073016608 Peptidase family M28; Region: Peptidase_M28; pfam04389 1278073016609 metal binding site [ion binding]; metal-binding site 1278073016610 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 1278073016611 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 1278073016612 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1278073016613 classical (c) SDRs; Region: SDR_c; cd05233 1278073016614 NAD(P) binding site [chemical binding]; other site 1278073016615 active site 1278073016616 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1278073016617 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1278073016618 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1278073016619 Class I hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classI; cd00643 1278073016620 tetramerization interface [polypeptide binding]; other site 1278073016621 substrate binding pocket [chemical binding]; other site 1278073016622 catalytic residues [active] 1278073016623 inhibitor binding sites; inhibition site 1278073016624 NADP(H) binding site [chemical binding]; other site 1278073016625 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1278073016626 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1278073016627 TPR motif; other site 1278073016628 binding surface 1278073016629 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073016630 TPR motif; other site 1278073016631 TPR repeat; Region: TPR_11; pfam13414 1278073016632 binding surface 1278073016633 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1278073016634 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073016635 S-adenosylmethionine binding site [chemical binding]; other site 1278073016636 aminoglycoside resistance protein; Provisional; Region: PRK13746 1278073016637 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1278073016638 active site 1278073016639 NTP binding site [chemical binding]; other site 1278073016640 metal binding triad [ion binding]; metal-binding site 1278073016641 antibiotic binding site [chemical binding]; other site 1278073016642 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 1278073016643 Tubby C 2; Region: Tub_2; cl02043 1278073016644 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1278073016645 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1278073016646 catalytic site [active] 1278073016647 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1278073016648 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073016649 active site 1278073016650 phosphorylation site [posttranslational modification] 1278073016651 intermolecular recognition site; other site 1278073016652 dimerization interface [polypeptide binding]; other site 1278073016653 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1278073016654 DNA binding site [nucleotide binding] 1278073016655 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073016656 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073016657 dimer interface [polypeptide binding]; other site 1278073016658 phosphorylation site [posttranslational modification] 1278073016659 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073016660 ATP binding site [chemical binding]; other site 1278073016661 Mg2+ binding site [ion binding]; other site 1278073016662 G-X-G motif; other site 1278073016663 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 1278073016664 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1278073016665 Beta-lactamase; Region: Beta-lactamase; pfam00144 1278073016666 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1278073016667 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1278073016668 active site 1278073016669 Zn binding site [ion binding]; other site 1278073016670 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1278073016671 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1278073016672 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1278073016673 dimerization interface [polypeptide binding]; other site 1278073016674 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1278073016675 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1278073016676 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1278073016677 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1278073016678 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1278073016679 nucleoside/Zn binding site; other site 1278073016680 dimer interface [polypeptide binding]; other site 1278073016681 catalytic motif [active] 1278073016682 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 1278073016683 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1278073016684 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1278073016685 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1278073016686 active site 1278073016687 HTH domain; Region: HTH_11; pfam08279 1278073016688 WYL domain; Region: WYL; pfam13280 1278073016689 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073016690 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1278073016691 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1278073016692 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1278073016693 active site 1278073016694 metal binding site [ion binding]; metal-binding site 1278073016695 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1278073016696 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1278073016697 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1278073016698 structural tetrad; other site 1278073016699 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1278073016700 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1278073016701 structural tetrad; other site 1278073016702 TPR repeat; Region: TPR_11; pfam13414 1278073016703 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073016704 binding surface 1278073016705 TPR motif; other site 1278073016706 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 1278073016707 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1278073016708 active site 1278073016709 homotetramer interface [polypeptide binding]; other site 1278073016710 HflC protein; Region: hflC; TIGR01932 1278073016711 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1278073016712 HflK protein; Region: hflK; TIGR01933 1278073016713 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1278073016714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1278073016715 putative substrate translocation pore; other site 1278073016716 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1278073016717 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 1278073016718 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1278073016719 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1278073016720 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1278073016721 substrate binding pocket [chemical binding]; other site 1278073016722 substrate-Mg2+ binding site; other site 1278073016723 aspartate-rich region 1; other site 1278073016724 aspartate-rich region 2; other site 1278073016725 DTW domain; Region: DTW; cl01221 1278073016726 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 1278073016727 dinuclear metal binding motif [ion binding]; other site 1278073016728 Annexin; Region: Annexin; pfam00191 1278073016729 Annexin; Region: Annexin; pfam00191 1278073016730 Annexin; Region: Annexin; pfam00191 1278073016731 Family description; Region: VCBS; pfam13517 1278073016732 Family description; Region: VCBS; pfam13517 1278073016733 Family description; Region: VCBS; pfam13517 1278073016734 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1278073016735 Beta-lactamase; Region: Beta-lactamase; pfam00144 1278073016736 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073016737 S-adenosylmethionine binding site [chemical binding]; other site 1278073016738 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 1278073016739 Cupin domain; Region: Cupin_2; cl17218 1278073016740 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1278073016741 DNA-binding site [nucleotide binding]; DNA binding site 1278073016742 RNA-binding motif; other site 1278073016743 Heavy-metal resistance; Region: Metal_resist; pfam13801 1278073016744 dimer interface [polypeptide binding]; other site 1278073016745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1278073016746 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073016747 active site 1278073016748 phosphorylation site [posttranslational modification] 1278073016749 intermolecular recognition site; other site 1278073016750 dimerization interface [polypeptide binding]; other site 1278073016751 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1278073016752 DNA binding site [nucleotide binding] 1278073016753 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1278073016754 dimerization interface [polypeptide binding]; other site 1278073016755 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073016756 dimer interface [polypeptide binding]; other site 1278073016757 phosphorylation site [posttranslational modification] 1278073016758 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073016759 ATP binding site [chemical binding]; other site 1278073016760 Mg2+ binding site [ion binding]; other site 1278073016761 G-X-G motif; other site 1278073016762 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073016763 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1278073016764 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1278073016765 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1278073016766 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073016767 Walker A/P-loop; other site 1278073016768 ATP binding site [chemical binding]; other site 1278073016769 Q-loop/lid; other site 1278073016770 ABC transporter signature motif; other site 1278073016771 Walker B; other site 1278073016772 D-loop; other site 1278073016773 H-loop/switch region; other site 1278073016774 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1278073016775 UbiA prenyltransferase family; Region: UbiA; pfam01040 1278073016776 TPR repeat; Region: TPR_11; pfam13414 1278073016777 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073016778 binding surface 1278073016779 TPR motif; other site 1278073016780 TPR repeat; Region: TPR_11; pfam13414 1278073016781 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073016782 binding surface 1278073016783 TPR motif; other site 1278073016784 TPR repeat; Region: TPR_11; pfam13414 1278073016785 TPR repeat; Region: TPR_11; pfam13414 1278073016786 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073016787 TPR motif; other site 1278073016788 binding surface 1278073016789 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1278073016790 Domain of unknown function (DUF2760); Region: DUF2760; pfam10816 1278073016791 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 1278073016792 nucleotide binding site [chemical binding]; other site 1278073016793 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1278073016794 SBD interface [polypeptide binding]; other site 1278073016795 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 1278073016796 nucleotide binding site [chemical binding]; other site 1278073016797 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1278073016798 SBD interface [polypeptide binding]; other site 1278073016799 DNA-K related protein; Region: DUF3731; pfam12531 1278073016800 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1278073016801 active site 1278073016802 metal binding site [ion binding]; metal-binding site 1278073016803 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1278073016804 Phytase; Region: Phytase; cl17685 1278073016805 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1278073016806 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1278073016807 NADP-binding site; other site 1278073016808 homotetramer interface [polypeptide binding]; other site 1278073016809 substrate binding site [chemical binding]; other site 1278073016810 homodimer interface [polypeptide binding]; other site 1278073016811 active site 1278073016812 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1278073016813 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1278073016814 NADP-binding site; other site 1278073016815 homotetramer interface [polypeptide binding]; other site 1278073016816 substrate binding site [chemical binding]; other site 1278073016817 homodimer interface [polypeptide binding]; other site 1278073016818 active site 1278073016819 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 1278073016820 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1278073016821 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1278073016822 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1278073016823 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1278073016824 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1278073016825 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1278073016826 putative bifunctional glutamate synthase subunit beta/2-polyprenylphenol hydroxylase; Validated; Region: PRK06567 1278073016827 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192 1278073016828 FAD binding pocket [chemical binding]; other site 1278073016829 FAD binding motif [chemical binding]; other site 1278073016830 phosphate binding motif [ion binding]; other site 1278073016831 beta-alpha-beta structure motif; other site 1278073016832 NAD binding pocket [chemical binding]; other site 1278073016833 Iron coordination center [ion binding]; other site 1278073016834 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1278073016835 catalytic core [active] 1278073016836 iron donor protein CyaY; Region: FeS_CyaY; TIGR03421 1278073016837 putative iron binding site [ion binding]; other site 1278073016838 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1278073016839 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1278073016840 metal binding site [ion binding]; metal-binding site 1278073016841 I-site; other site 1278073016842 active site 1278073016843 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1278073016844 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1278073016845 hinge region; other site 1278073016846 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1278073016847 putative nucleotide binding site [chemical binding]; other site 1278073016848 uridine monophosphate binding site [chemical binding]; other site 1278073016849 homohexameric interface [polypeptide binding]; other site 1278073016850 elongation factor Ts; Reviewed; Region: tsf; PRK12332 1278073016851 UBA/TS-N domain; Region: UBA; pfam00627 1278073016852 Elongation factor TS; Region: EF_TS; pfam00889 1278073016853 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1278073016854 rRNA interaction site [nucleotide binding]; other site 1278073016855 S8 interaction site; other site 1278073016856 putative laminin-1 binding site; other site 1278073016857 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1278073016858 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1278073016859 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1278073016860 nucleotide binding region [chemical binding]; other site 1278073016861 SEC-C motif; Region: SEC-C; pfam02810 1278073016862 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073016863 S-adenosylmethionine binding site [chemical binding]; other site 1278073016864 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1278073016865 metal binding site [ion binding]; metal-binding site 1278073016866 nucleotidyl binding site; other site 1278073016867 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1278073016868 Peptidase family M23; Region: Peptidase_M23; pfam01551 1278073016869 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1278073016870 active site 1278073016871 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1278073016872 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1278073016873 Walker A/P-loop; other site 1278073016874 ATP binding site [chemical binding]; other site 1278073016875 Q-loop/lid; other site 1278073016876 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1278073016877 ABC transporter signature motif; other site 1278073016878 Walker B; other site 1278073016879 D-loop; other site 1278073016880 H-loop/switch region; other site 1278073016881 SWIM zinc finger; Region: SWIM; pfam04434 1278073016882 SNF2 Helicase protein; Region: DUF3670; pfam12419 1278073016883 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1278073016884 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1278073016885 ATP binding site [chemical binding]; other site 1278073016886 putative Mg++ binding site [ion binding]; other site 1278073016887 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1278073016888 nucleotide binding region [chemical binding]; other site 1278073016889 ATP-binding site [chemical binding]; other site 1278073016890 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1278073016891 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1278073016892 dimerization interface [polypeptide binding]; other site 1278073016893 ligand binding site [chemical binding]; other site 1278073016894 NADP binding site [chemical binding]; other site 1278073016895 catalytic site [active] 1278073016896 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1278073016897 active site 1278073016898 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1278073016899 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1278073016900 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1278073016901 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1278073016902 muropeptide transporter; Validated; Region: ampG; cl17669 1278073016903 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1278073016904 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1278073016905 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1278073016906 active site 1278073016907 (T/H)XGH motif; other site 1278073016908 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1278073016909 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 1278073016910 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 1278073016911 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1278073016912 catalytic site [active] 1278073016913 active site 1278073016914 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1278073016915 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 1278073016916 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1278073016917 active site 1278073016918 metal binding site [ion binding]; metal-binding site 1278073016919 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1278073016920 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 1278073016921 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1278073016922 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 1278073016923 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1278073016924 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1278073016925 putative active site [active] 1278073016926 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 1278073016927 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1278073016928 recombination factor protein RarA; Reviewed; Region: PRK13342 1278073016929 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073016930 Walker A motif; other site 1278073016931 ATP binding site [chemical binding]; other site 1278073016932 Walker B motif; other site 1278073016933 arginine finger; other site 1278073016934 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1278073016935 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073016936 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1278073016937 active site 1278073016938 phosphorylation site [posttranslational modification] 1278073016939 intermolecular recognition site; other site 1278073016940 dimerization interface [polypeptide binding]; other site 1278073016941 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073016942 Walker A motif; other site 1278073016943 ATP binding site [chemical binding]; other site 1278073016944 Walker B motif; other site 1278073016945 arginine finger; other site 1278073016946 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1278073016947 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073016948 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073016949 active site 1278073016950 phosphorylation site [posttranslational modification] 1278073016951 intermolecular recognition site; other site 1278073016952 dimerization interface [polypeptide binding]; other site 1278073016953 PAS domain; Region: PAS_9; pfam13426 1278073016954 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073016955 dimer interface [polypeptide binding]; other site 1278073016956 phosphorylation site [posttranslational modification] 1278073016957 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073016958 ATP binding site [chemical binding]; other site 1278073016959 G-X-G motif; other site 1278073016960 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1278073016961 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1278073016962 metal binding site [ion binding]; metal-binding site 1278073016963 active site 1278073016964 I-site; other site 1278073016965 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1278073016966 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1278073016967 Ligand binding site; other site 1278073016968 Putative Catalytic site; other site 1278073016969 DXD motif; other site 1278073016970 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1278073016971 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1278073016972 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073016973 S-adenosylmethionine binding site [chemical binding]; other site 1278073016974 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1278073016975 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1278073016976 substrate binding site [chemical binding]; other site 1278073016977 oxyanion hole (OAH) forming residues; other site 1278073016978 trimer interface [polypeptide binding]; other site 1278073016979 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1278073016980 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1278073016981 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1278073016982 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 1278073016983 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1278073016984 dimer interface [polypeptide binding]; other site 1278073016985 active site 1278073016986 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1278073016987 substrate binding site [chemical binding]; other site 1278073016988 active site 1278073016989 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 1278073016990 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1278073016991 active site 1278073016992 catalytic site [active] 1278073016993 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 1278073016994 starch-binding site 1 [chemical binding]; other site 1278073016995 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1278073016996 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1278073016997 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1278073016998 active site 1278073016999 catalytic site [active] 1278073017000 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1278073017001 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1278073017002 Walker A/P-loop; other site 1278073017003 ATP binding site [chemical binding]; other site 1278073017004 Q-loop/lid; other site 1278073017005 ABC transporter signature motif; other site 1278073017006 Walker B; other site 1278073017007 D-loop; other site 1278073017008 H-loop/switch region; other site 1278073017009 TOBE domain; Region: TOBE_2; pfam08402 1278073017010 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1278073017011 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1278073017012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1278073017013 dimer interface [polypeptide binding]; other site 1278073017014 conserved gate region; other site 1278073017015 putative PBP binding loops; other site 1278073017016 ABC-ATPase subunit interface; other site 1278073017017 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1278073017018 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1278073017019 dimer interface [polypeptide binding]; other site 1278073017020 conserved gate region; other site 1278073017021 putative PBP binding loops; other site 1278073017022 ABC-ATPase subunit interface; other site 1278073017023 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1278073017024 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1278073017025 cofactor binding site; other site 1278073017026 DNA binding site [nucleotide binding] 1278073017027 substrate interaction site [chemical binding]; other site 1278073017028 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073017029 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1278073017030 Walker A motif; other site 1278073017031 ATP binding site [chemical binding]; other site 1278073017032 Walker B motif; other site 1278073017033 arginine finger; other site 1278073017034 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 1278073017035 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1278073017036 putative active site [active] 1278073017037 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1278073017038 Transposase; Region: HTH_Tnp_1; pfam01527 1278073017039 HTH-like domain; Region: HTH_21; pfam13276 1278073017040 Integrase core domain; Region: rve; pfam00665 1278073017041 Integrase core domain; Region: rve_3; pfam13683 1278073017042 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1278073017043 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1278073017044 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1278073017045 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1278073017046 Di-iron ligands [ion binding]; other site 1278073017047 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1278073017048 Glutamine cyclotransferase [Posttranslational modification, protein turnover, chaperones]; Region: COG3823 1278073017049 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 1278073017050 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1278073017051 binding surface 1278073017052 TPR motif; other site 1278073017053 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1278073017054 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073017055 active site 1278073017056 phosphorylation site [posttranslational modification] 1278073017057 intermolecular recognition site; other site 1278073017058 dimerization interface [polypeptide binding]; other site 1278073017059 LytTr DNA-binding domain; Region: LytTR; smart00850 1278073017060 Histidine kinase; Region: His_kinase; pfam06580 1278073017061 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073017062 ATP binding site [chemical binding]; other site 1278073017063 Mg2+ binding site [ion binding]; other site 1278073017064 G-X-G motif; other site 1278073017065 Stigma-specific protein, Stig1; Region: Stig1; pfam04885 1278073017066 Uncharacterized conserved protein [Function unknown]; Region: COG4748 1278073017067 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 1278073017068 SIR2-like domain; Region: SIR2_2; pfam13289 1278073017069 C2 domain; Region: C2; cl14603 1278073017070 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1278073017071 intermolecular salt bridges; other site 1278073017072 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1278073017073 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1278073017074 active site 1278073017075 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1278073017076 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1278073017077 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1278073017078 substrate binding pocket [chemical binding]; other site 1278073017079 dimerization interface [polypeptide binding]; other site 1278073017080 haloalkane dehalogenase; Provisional; Region: PRK03592 1278073017081 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1278073017082 active site 1278073017083 catalytic residues [active] 1278073017084 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1278073017085 Fungalysin metallopeptidase (M36); Region: Peptidase_M36; pfam02128 1278073017086 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 1278073017087 Zn binding site [ion binding]; other site 1278073017088 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1278073017089 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1278073017090 active site 1278073017091 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1278073017092 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 1278073017093 Phage-related protein [Function unknown]; Region: COG5412 1278073017094 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1278073017095 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073017096 Walker A motif; other site 1278073017097 ATP binding site [chemical binding]; other site 1278073017098 Walker B motif; other site 1278073017099 arginine finger; other site 1278073017100 tRNA dimethylallyltransferase; Region: miaA; TIGR00174 1278073017101 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 1278073017102 PAAR motif; Region: PAAR_motif; pfam05488 1278073017103 Phage protein D [General function prediction only]; Region: COG3500 1278073017104 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 1278073017105 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1278073017106 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 1278073017107 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 1278073017108 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 1278073017109 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 1278073017110 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 1278073017111 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1278073017112 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1278073017113 putative sugar binding sites [chemical binding]; other site 1278073017114 Q-X-W motif; other site 1278073017115 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1278073017116 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073017117 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1278073017118 active site 1278073017119 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1278073017120 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1278073017121 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073017122 active site 1278073017123 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1278073017124 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1278073017125 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1278073017126 KR domain; Region: KR; pfam08659 1278073017127 putative NADP binding site [chemical binding]; other site 1278073017128 active site 1278073017129 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1278073017130 bacteriocin maturation radical SAM protein 1; Region: rSAM_ocin_1; TIGR03975 1278073017131 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1278073017132 B12 binding site [chemical binding]; other site 1278073017133 Methyltransferase in polyketide synthase (PKS) enzymes; Region: PKS_MT; smart00828 1278073017134 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1278073017135 KR domain; Region: KR; pfam08659 1278073017136 putative NADP binding site [chemical binding]; other site 1278073017137 active site 1278073017138 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1278073017139 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 1278073017140 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 1278073017141 nucleophile elbow; other site 1278073017142 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1278073017143 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073017144 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073017145 acyl-activating enzyme (AAE) consensus motif; other site 1278073017146 AMP binding site [chemical binding]; other site 1278073017147 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073017148 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1278073017149 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1278073017150 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073017151 active site 1278073017152 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1278073017153 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1278073017154 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1278073017155 putative NADP binding site [chemical binding]; other site 1278073017156 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1278073017157 active site 1278073017158 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1278073017159 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1278073017160 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073017161 active site 1278073017162 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1278073017163 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1278073017164 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1278073017165 putative NADP binding site [chemical binding]; other site 1278073017166 KR domain; Region: KR; pfam08659 1278073017167 active site 1278073017168 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1278073017169 Condensation domain; Region: Condensation; pfam00668 1278073017170 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073017171 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1278073017172 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1278073017173 acyl-activating enzyme (AAE) consensus motif; other site 1278073017174 AMP binding site [chemical binding]; other site 1278073017175 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073017176 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073017177 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1278073017178 active site 1278073017179 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1278073017180 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1278073017181 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1278073017182 putative NADP binding site [chemical binding]; other site 1278073017183 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1278073017184 active site 1278073017185 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1278073017186 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073017187 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1278073017188 active site 1278073017189 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1278073017190 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1278073017191 KR domain; Region: KR; pfam08659 1278073017192 putative NADP binding site [chemical binding]; other site 1278073017193 active site 1278073017194 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073017195 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073017196 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1278073017197 active site 1278073017198 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1278073017199 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1278073017200 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1278073017201 active site 1278073017202 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1278073017203 AMP-binding enzyme; Region: AMP-binding; pfam00501 1278073017204 acyl-activating enzyme (AAE) consensus motif; other site 1278073017205 AMP binding site [chemical binding]; other site 1278073017206 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1278073017207 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 1278073017208 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1278073017209 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 1278073017210 active site 1278073017211 FMN binding site [chemical binding]; other site 1278073017212 substrate binding site [chemical binding]; other site 1278073017213 putative catalytic residue [active] 1278073017214 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1278073017215 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 1278073017216 putative di-iron ligands [ion binding]; other site 1278073017217 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1278073017218 active site 1278073017219 Acyl transferase domain; Region: Acyl_transf_1; cl08282 1278073017220 Beta-ketoacyl synthase, N-terminal domain; Region: ketoacyl-synt; pfam00109 1278073017221 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1278073017222 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1278073017223 active site 1278073017224 active site 1278073017225 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1278073017226 active site 1278073017227 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073017228 NAD(P) binding site [chemical binding]; other site 1278073017229 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1278073017230 active site 1278073017231 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1278073017232 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1278073017233 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 1278073017234 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 1278073017235 putative NAD(P) binding site [chemical binding]; other site 1278073017236 active site 1278073017237 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 1278073017238 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 1278073017239 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1278073017240 Interdomain contacts; other site 1278073017241 Cytokine receptor motif; other site 1278073017242 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 1278073017243 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 1278073017244 putative active site [active] 1278073017245 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1278073017246 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1278073017247 ATP binding site [chemical binding]; other site 1278073017248 putative Mg++ binding site [ion binding]; other site 1278073017249 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1278073017250 nucleotide binding region [chemical binding]; other site 1278073017251 ATP-binding site [chemical binding]; other site 1278073017252 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073017253 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1278073017254 active site 1278073017255 ATP binding site [chemical binding]; other site 1278073017256 substrate binding site [chemical binding]; other site 1278073017257 activation loop (A-loop); other site 1278073017258 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1278073017259 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1278073017260 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1278073017261 TPR motif; other site 1278073017262 binding surface 1278073017263 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1278073017264 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1278073017265 RNA polymerase sigma-70 factor, Myxococcales family 1; Region: Sig-70_gmx1; TIGR03001 1278073017266 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1278073017267 DNA binding residues [nucleotide binding] 1278073017268 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 1278073017269 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1278073017270 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1278073017271 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1278073017272 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1278073017273 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cl00089 1278073017274 active site 1278073017275 substrate binding site [chemical binding]; other site 1278073017276 Mg2+ binding site [ion binding]; other site 1278073017277 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 1278073017278 dimerization interface [polypeptide binding]; other site 1278073017279 putative catalytic residue [active] 1278073017280 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1278073017281 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1278073017282 Peptidase family M28; Region: Peptidase_M28; pfam04389 1278073017283 metal binding site [ion binding]; metal-binding site 1278073017284 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1278073017285 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1278073017286 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1278073017287 dimerization interface [polypeptide binding]; other site 1278073017288 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1278073017289 SnoaL-like domain; Region: SnoaL_3; pfam13474 1278073017290 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1278073017291 SnoaL-like domain; Region: SnoaL_3; pfam13474 1278073017292 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073017293 S-adenosylmethionine binding site [chemical binding]; other site 1278073017294 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1278073017295 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1278073017296 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1278073017297 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 1278073017298 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1278073017299 metal ion-dependent adhesion site (MIDAS); other site 1278073017300 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073017301 binding surface 1278073017302 TPR motif; other site 1278073017303 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1278073017304 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1278073017305 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1278073017306 GMC oxidoreductase; Region: GMC_oxred_N; pfam00732 1278073017307 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1278073017308 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 1278073017309 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1278073017310 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1278073017311 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1278073017312 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1278073017313 Family description; Region: UvrD_C_2; pfam13538 1278073017314 PAS fold; Region: PAS_4; pfam08448 1278073017315 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1278073017316 putative active site [active] 1278073017317 heme pocket [chemical binding]; other site 1278073017318 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1278073017319 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1278073017320 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073017321 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073017322 dimer interface [polypeptide binding]; other site 1278073017323 phosphorylation site [posttranslational modification] 1278073017324 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073017325 ATP binding site [chemical binding]; other site 1278073017326 Mg2+ binding site [ion binding]; other site 1278073017327 G-X-G motif; other site 1278073017328 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073017329 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073017330 dimer interface [polypeptide binding]; other site 1278073017331 phosphorylation site [posttranslational modification] 1278073017332 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073017333 ATP binding site [chemical binding]; other site 1278073017334 Mg2+ binding site [ion binding]; other site 1278073017335 G-X-G motif; other site 1278073017336 Pectinacetylesterase; Region: PAE; pfam03283 1278073017337 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 1278073017338 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 1278073017339 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 1278073017340 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 1278073017341 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 1278073017342 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 1278073017343 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1278073017344 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1278073017345 active site 1278073017346 dimer interface [polypeptide binding]; other site 1278073017347 Beta-propeller repeat; Region: SBBP; pfam06739 1278073017348 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 1278073017349 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1278073017350 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1278073017351 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1278073017352 dimerization interface [polypeptide binding]; other site 1278073017353 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 1278073017354 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1278073017355 ArsC family; Region: ArsC; pfam03960 1278073017356 putative ArsC-like catalytic residues; other site 1278073017357 putative TRX-like catalytic residues [active] 1278073017358 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1278073017359 SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829 1278073017360 active site 1278073017361 catalytic triad [active] 1278073017362 oxyanion hole [active] 1278073017363 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1278073017364 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1278073017365 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073017366 Walker A/P-loop; other site 1278073017367 ATP binding site [chemical binding]; other site 1278073017368 Q-loop/lid; other site 1278073017369 ABC transporter signature motif; other site 1278073017370 Walker B; other site 1278073017371 D-loop; other site 1278073017372 H-loop/switch region; other site 1278073017373 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1278073017374 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1278073017375 substrate binding pocket [chemical binding]; other site 1278073017376 membrane-bound complex binding site; other site 1278073017377 hinge residues; other site 1278073017378 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1278073017379 dimer interface [polypeptide binding]; other site 1278073017380 conserved gate region; other site 1278073017381 ABC-ATPase subunit interface; other site 1278073017382 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073017383 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073017384 active site 1278073017385 phosphorylation site [posttranslational modification] 1278073017386 intermolecular recognition site; other site 1278073017387 dimerization interface [polypeptide binding]; other site 1278073017388 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073017389 dimer interface [polypeptide binding]; other site 1278073017390 phosphorylation site [posttranslational modification] 1278073017391 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073017392 ATP binding site [chemical binding]; other site 1278073017393 Mg2+ binding site [ion binding]; other site 1278073017394 G-X-G motif; other site 1278073017395 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1278073017396 Cytochrome P450; Region: p450; cl12078 1278073017397 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 1278073017398 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1278073017399 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1278073017400 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073017401 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1278073017402 DNA binding residues [nucleotide binding] 1278073017403 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073017404 binding surface 1278073017405 TPR motif; other site 1278073017406 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1278073017407 TPR repeat; Region: TPR_11; pfam13414 1278073017408 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073017409 binding surface 1278073017410 TPR motif; other site 1278073017411 CHAT domain; Region: CHAT; cl17868 1278073017412 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1278073017413 Part of AAA domain; Region: AAA_19; pfam13245 1278073017414 AAA domain; Region: AAA_30; pfam13604 1278073017415 AAA domain; Region: AAA_12; pfam13087 1278073017416 Family description; Region: UvrD_C_2; pfam13538 1278073017417 uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904 1278073017418 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 1278073017419 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 1278073017420 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 1278073017421 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1278073017422 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1278073017423 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1278073017424 RNA binding surface [nucleotide binding]; other site 1278073017425 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1278073017426 active site 1278073017427 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1278073017428 protein-splicing catalytic site; other site 1278073017429 thioester formation/cholesterol transfer; other site 1278073017430 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1278073017431 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1278073017432 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1278073017433 FAD binding domain; Region: FAD_binding_4; pfam01565 1278073017434 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073017435 NAD(P) binding site [chemical binding]; other site 1278073017436 active site 1278073017437 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1278073017438 putative acyl-acceptor binding pocket; other site 1278073017439 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1278073017440 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073017441 NAD(P) binding site [chemical binding]; other site 1278073017442 active site 1278073017443 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 1278073017444 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073017445 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073017446 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073017447 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 1278073017448 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1278073017449 protein binding site [polypeptide binding]; other site 1278073017450 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 1278073017451 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1278073017452 active site 1278073017453 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1278073017454 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1278073017455 putative di-iron ligands [ion binding]; other site 1278073017456 Protein of unknown function (DUF3419); Region: DUF3419; cl15422 1278073017457 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1278073017458 Coenzyme A binding pocket [chemical binding]; other site 1278073017459 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1278073017460 catalytic core [active] 1278073017461 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1278073017462 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1278073017463 FeS/SAM binding site; other site 1278073017464 HemN C-terminal domain; Region: HemN_C; pfam06969 1278073017465 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 1278073017466 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1278073017467 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 1278073017468 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 1278073017469 Cytochrome c; Region: Cytochrom_C; pfam00034 1278073017470 putative bifunctional cbb3-type cytochrome c oxidase subunit I/II; Provisional; Region: PRK14485 1278073017471 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 1278073017472 Putative water exit pathway; other site 1278073017473 Binuclear center (active site) [active] 1278073017474 Putative proton exit pathway; other site 1278073017475 Low-spin heme binding site [chemical binding]; other site 1278073017476 cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487 1278073017477 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 1278073017478 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1278073017479 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1278073017480 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1278073017481 Family description; Region: DsbD_2; pfam13386 1278073017482 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 1278073017483 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 1278073017484 putative hydrophobic ligand binding site [chemical binding]; other site 1278073017485 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 1278073017486 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1278073017487 dimer interface [polypeptide binding]; other site 1278073017488 active site 1278073017489 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1278073017490 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1278073017491 SEC-C motif; Region: SEC-C; pfam02810 1278073017492 putative oxidoreductase; Provisional; Region: PRK11579 1278073017493 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1278073017494 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1278073017495 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1278073017496 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 1278073017497 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 1278073017498 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 1278073017499 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1278073017500 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1278073017501 molybdopterin cofactor binding site; other site 1278073017502 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 1278073017503 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 1278073017504 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 1278073017505 heme-binding residues [chemical binding]; other site 1278073017506 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 1278073017507 Cytochrome c; Region: Cytochrom_C; pfam00034 1278073017508 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 1278073017509 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1278073017510 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1278073017511 proposed catalytic triad [active] 1278073017512 conserved cys residue [active] 1278073017513 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1278073017514 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 1278073017515 putative active site [active] 1278073017516 putative metal binding site [ion binding]; other site 1278073017517 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1278073017518 RibD C-terminal domain; Region: RibD_C; cl17279 1278073017519 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1278073017520 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073017521 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073017522 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073017523 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073017524 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073017525 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073017526 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073017527 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073017528 spermidine synthase; Provisional; Region: PRK03612 1278073017529 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073017530 S-adenosylmethionine binding site [chemical binding]; other site 1278073017531 H+ Antiporter protein; Region: 2A0121; TIGR00900 1278073017532 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1278073017533 putative substrate translocation pore; other site 1278073017534 Arginase family; Region: Arginase; pfam00491 1278073017535 active site 1278073017536 metal binding site [ion binding]; metal-binding site 1278073017537 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1278073017538 Peptidase family M28; Region: Peptidase_M28; pfam04389 1278073017539 metal binding site [ion binding]; metal-binding site 1278073017540 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 1278073017541 putative ligand binding site [chemical binding]; other site 1278073017542 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 1278073017543 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 1278073017544 Condensation domain; Region: Condensation; pfam00668 1278073017545 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073017546 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073017547 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 1278073017548 acyl-activating enzyme (AAE) consensus motif; other site 1278073017549 AMP binding site [chemical binding]; other site 1278073017550 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073017551 Condensation domain; Region: Condensation; pfam00668 1278073017552 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073017553 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073017554 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 1278073017555 acyl-activating enzyme (AAE) consensus motif; other site 1278073017556 AMP binding site [chemical binding]; other site 1278073017557 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073017558 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1278073017559 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073017560 acyl-activating enzyme (AAE) consensus motif; other site 1278073017561 AMP binding site [chemical binding]; other site 1278073017562 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073017563 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1278073017564 [2Fe-2S] cluster binding site [ion binding]; other site 1278073017565 iron-sulfur cluster [ion binding]; other site 1278073017566 Condensation domain; Region: Condensation; pfam00668 1278073017567 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073017568 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073017569 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073017570 acyl-activating enzyme (AAE) consensus motif; other site 1278073017571 AMP binding site [chemical binding]; other site 1278073017572 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073017573 Condensation domain; Region: Condensation; pfam00668 1278073017574 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073017575 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073017576 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073017577 acyl-activating enzyme (AAE) consensus motif; other site 1278073017578 AMP binding site [chemical binding]; other site 1278073017579 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073017580 Condensation domain; Region: Condensation; pfam00668 1278073017581 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073017582 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073017583 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1278073017584 acyl-activating enzyme (AAE) consensus motif; other site 1278073017585 AMP binding site [chemical binding]; other site 1278073017586 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1278073017587 hexokinase; Region: PLN02914 1278073017588 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 1278073017589 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1278073017590 putative di-iron ligands [ion binding]; other site 1278073017591 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1278073017592 B3/4 domain; Region: B3_4; pfam03483 1278073017593 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1278073017594 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1278073017595 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1278073017596 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 1278073017597 Predicted periplasmic lipoprotein (DUF2279); Region: DUF2279; cl11574 1278073017598 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 1278073017599 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1278073017600 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 1278073017601 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1278073017602 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1278073017603 putative RNA binding site [nucleotide binding]; other site 1278073017604 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073017605 S-adenosylmethionine binding site [chemical binding]; other site 1278073017606 Flagellin N-methylase; Region: FliB; pfam03692 1278073017607 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1278073017608 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1278073017609 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 1278073017610 active site 1278073017611 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1278073017612 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1278073017613 dimer interface [polypeptide binding]; other site 1278073017614 substrate binding site [chemical binding]; other site 1278073017615 metal binding sites [ion binding]; metal-binding site 1278073017616 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1278073017617 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1278073017618 putative acyl-acceptor binding pocket; other site 1278073017619 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1278073017620 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 1278073017621 motif 1; other site 1278073017622 dimer interface [polypeptide binding]; other site 1278073017623 active site 1278073017624 motif 2; other site 1278073017625 motif 3; other site 1278073017626 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1278073017627 Zn binding site [ion binding]; other site 1278073017628 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1278073017629 Short C-terminal domain; Region: SHOCT; pfam09851 1278073017630 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1278073017631 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1278073017632 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1278073017633 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1278073017634 Walker A/P-loop; other site 1278073017635 ATP binding site [chemical binding]; other site 1278073017636 Q-loop/lid; other site 1278073017637 ABC transporter signature motif; other site 1278073017638 Walker B; other site 1278073017639 D-loop; other site 1278073017640 H-loop/switch region; other site 1278073017641 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1278073017642 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1278073017643 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1278073017644 putative RNA ligase; Region: PHA02142 1278073017645 RNA ligase; Region: RNA_ligase; pfam09414 1278073017646 Rhomboid family; Region: Rhomboid; cl11446 1278073017647 MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane...; Region: MATH; cl02446 1278073017648 putative substrate binding site [chemical binding]; other site 1278073017649 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1278073017650 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1278073017651 phosphopeptide binding site; other site 1278073017652 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1278073017653 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1278073017654 phosphopeptide binding site; other site 1278073017655 TPR repeat; Region: TPR_11; pfam13414 1278073017656 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073017657 binding surface 1278073017658 TPR motif; other site 1278073017659 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073017660 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073017661 active site 1278073017662 phosphorylation site [posttranslational modification] 1278073017663 intermolecular recognition site; other site 1278073017664 dimerization interface [polypeptide binding]; other site 1278073017665 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1278073017666 non-specific DNA binding site [nucleotide binding]; other site 1278073017667 salt bridge; other site 1278073017668 sequence-specific DNA binding site [nucleotide binding]; other site 1278073017669 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1278073017670 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1278073017671 substrate binding site [chemical binding]; other site 1278073017672 oxyanion hole (OAH) forming residues; other site 1278073017673 trimer interface [polypeptide binding]; other site 1278073017674 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 1278073017675 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1278073017676 carboxyltransferase (CT) interaction site; other site 1278073017677 biotinylation site [posttranslational modification]; other site 1278073017678 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1278073017679 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1278073017680 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1278073017681 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1278073017682 cell division protein FtsZ; Validated; Region: PRK09330 1278073017683 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1278073017684 nucleotide binding site [chemical binding]; other site 1278073017685 SulA interaction site; other site 1278073017686 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1278073017687 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1278073017688 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 1278073017689 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1278073017690 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1278073017691 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1278073017692 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1278073017693 ligand binding site [chemical binding]; other site 1278073017694 cell division protein FtsA; Region: ftsA; TIGR01174 1278073017695 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1278073017696 nucleotide binding site [chemical binding]; other site 1278073017697 Cell division protein FtsA; Region: FtsA; pfam14450 1278073017698 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1278073017699 Cell division protein FtsQ; Region: FtsQ; pfam03799 1278073017700 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1278073017701 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1278073017702 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1278073017703 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK14652 1278073017704 FAD binding domain; Region: FAD_binding_4; pfam01565 1278073017705 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1278073017706 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1278073017707 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1278073017708 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1278073017709 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1278073017710 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 1278073017711 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1278073017712 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1278073017713 active site 1278073017714 homodimer interface [polypeptide binding]; other site 1278073017715 cell division protein FtsW; Region: ftsW; TIGR02614 1278073017716 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 1278073017717 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 1278073017718 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1278073017719 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1278073017720 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1278073017721 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1278073017722 Mg++ binding site [ion binding]; other site 1278073017723 putative catalytic motif [active] 1278073017724 putative substrate binding site [chemical binding]; other site 1278073017725 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1278073017726 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1278073017727 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1278073017728 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1278073017729 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1278073017730 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1278073017731 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1278073017732 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1278073017733 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1278073017734 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1278073017735 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1278073017736 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1278073017737 Cell division protein FtsL; Region: FtsL; pfam04999 1278073017738 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1278073017739 MraW methylase family; Region: Methyltransf_5; cl17771 1278073017740 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1278073017741 anti sigma factor interaction site; other site 1278073017742 regulatory phosphorylation site [posttranslational modification]; other site 1278073017743 cell division protein MraZ; Reviewed; Region: PRK00326 1278073017744 MraZ protein; Region: MraZ; pfam02381 1278073017745 MraZ protein; Region: MraZ; pfam02381 1278073017746 PilZ domain; Region: PilZ; cl01260 1278073017747 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1278073017748 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1278073017749 active site 1278073017750 Uncharacterized conserved protein [Function unknown]; Region: COG4850 1278073017751 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 1278073017752 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1278073017753 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073017754 active site 1278073017755 ATP binding site [chemical binding]; other site 1278073017756 substrate binding site [chemical binding]; other site 1278073017757 activation loop (A-loop); other site 1278073017758 Herpesvirus large structural phosphoprotein UL32; Region: Herpes_UL32; pfam06070 1278073017759 PEGA domain; Region: PEGA; pfam08308 1278073017760 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 1278073017761 Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cl17349 1278073017762 active site 1278073017763 Zn binding site [ion binding]; other site 1278073017764 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1278073017765 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1278073017766 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1278073017767 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1278073017768 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1278073017769 active site 1278073017770 TDP-binding site; other site 1278073017771 acceptor substrate-binding pocket; other site 1278073017772 homodimer interface [polypeptide binding]; other site 1278073017773 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1278073017774 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 1278073017775 putative active site [active] 1278073017776 metal binding site [ion binding]; metal-binding site 1278073017777 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1278073017778 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1278073017779 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1278073017780 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1278073017781 NAD(P) binding site [chemical binding]; other site 1278073017782 catalytic residues [active] 1278073017783 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1278073017784 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1278073017785 catalytic triad [active] 1278073017786 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073017787 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073017788 ATP binding site [chemical binding]; other site 1278073017789 G-X-G motif; other site 1278073017790 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1278073017791 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1278073017792 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1278073017793 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1278073017794 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1278073017795 RNA binding site [nucleotide binding]; other site 1278073017796 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1278073017797 multimer interface [polypeptide binding]; other site 1278073017798 Walker A motif; other site 1278073017799 ATP binding site [chemical binding]; other site 1278073017800 Walker B motif; other site 1278073017801 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1278073017802 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1278073017803 nucleotide binding pocket [chemical binding]; other site 1278073017804 K-X-D-G motif; other site 1278073017805 catalytic site [active] 1278073017806 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1278073017807 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1278073017808 UDP-glycosyltransferase family protein; Region: PLN02554 1278073017809 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1278073017810 Dimer interface [polypeptide binding]; other site 1278073017811 BRCT sequence motif; other site 1278073017812 Acylphosphatase; Region: Acylphosphatase; pfam00708 1278073017813 Trehalose-6-phosphate synthase [Carbohydrate transport and metabolism]; Region: OtsA; COG0380 1278073017814 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1278073017815 homodimer interface [polypeptide binding]; other site 1278073017816 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1278073017817 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 1278073017818 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1278073017819 MarR family; Region: MarR_2; pfam12802 1278073017820 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1278073017821 IHF dimer interface [polypeptide binding]; other site 1278073017822 IHF - DNA interface [nucleotide binding]; other site 1278073017823 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 1278073017824 FHIPEP family; Region: FHIPEP; pfam00771 1278073017825 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1278073017826 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1278073017827 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 1278073017828 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1278073017829 FliP family; Region: FliP; cl00593 1278073017830 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 1278073017831 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 1278073017832 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1278073017833 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1278073017834 PilZ domain; Region: PilZ; pfam07238 1278073017835 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073017836 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073017837 active site 1278073017838 phosphorylation site [posttranslational modification] 1278073017839 intermolecular recognition site; other site 1278073017840 dimerization interface [polypeptide binding]; other site 1278073017841 TPR repeat; Region: TPR_11; pfam13414 1278073017842 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073017843 binding surface 1278073017844 TPR motif; other site 1278073017845 TPR repeat; Region: TPR_11; pfam13414 1278073017846 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073017847 binding surface 1278073017848 TPR motif; other site 1278073017849 Oxygen tolerance; Region: BatD; pfam13584 1278073017850 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073017851 binding surface 1278073017852 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1278073017853 TPR motif; other site 1278073017854 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1278073017855 metal ion-dependent adhesion site (MIDAS); other site 1278073017856 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 1278073017857 metal ion-dependent adhesion site (MIDAS); other site 1278073017858 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1278073017859 Protein of unknown function DUF58; Region: DUF58; pfam01882 1278073017860 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1278073017861 metal ion-dependent adhesion site (MIDAS); other site 1278073017862 MoxR-like ATPases [General function prediction only]; Region: COG0714 1278073017863 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073017864 Walker A motif; other site 1278073017865 ATP binding site [chemical binding]; other site 1278073017866 Walker B motif; other site 1278073017867 arginine finger; other site 1278073017868 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1278073017869 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_2; cd06239 1278073017870 putative active site [active] 1278073017871 Zn binding site [ion binding]; other site 1278073017872 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 1278073017873 Domain of unknown function (DUF4401); Region: DUF4401; pfam14351 1278073017874 Protein of unknown function (DUF3260); Region: DUF3260; cl11881 1278073017875 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 1278073017876 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 1278073017877 heme binding pocket [chemical binding]; other site 1278073017878 heme ligand [chemical binding]; other site 1278073017879 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 1278073017880 classical (c) SDRs; Region: SDR_c; cd05233 1278073017881 NAD(P) binding site [chemical binding]; other site 1278073017882 active site 1278073017883 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073017884 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1278073017885 Walker A motif; other site 1278073017886 ATP binding site [chemical binding]; other site 1278073017887 Walker B motif; other site 1278073017888 arginine finger; other site 1278073017889 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073017890 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073017891 active site 1278073017892 ATP binding site [chemical binding]; other site 1278073017893 substrate binding site [chemical binding]; other site 1278073017894 activation loop (A-loop); other site 1278073017895 AAA ATPase domain; Region: AAA_16; pfam13191 1278073017896 Uncharacterized conserved protein [Function unknown]; Region: COG1944 1278073017897 YcaO-like family; Region: YcaO; pfam02624 1278073017898 Uncharacterized conserved protein [Function unknown]; Region: COG3482 1278073017899 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073017900 S-adenosylmethionine binding site [chemical binding]; other site 1278073017901 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1278073017902 FOG: CBS domain [General function prediction only]; Region: COG0517 1278073017903 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1278073017904 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 1278073017905 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 1278073017906 uncharacterized proteobacterial lipoprotein; Region: lp_; TIGR02722 1278073017907 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1278073017908 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1278073017909 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073017910 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073017911 active site 1278073017912 phosphorylation site [posttranslational modification] 1278073017913 intermolecular recognition site; other site 1278073017914 dimerization interface [polypeptide binding]; other site 1278073017915 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1278073017916 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1278073017917 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 1278073017918 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1278073017919 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1278073017920 catalytic residue [active] 1278073017921 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1278073017922 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1278073017923 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1278073017924 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1278073017925 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1278073017926 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1278073017927 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 1278073017928 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073017929 Walker A motif; other site 1278073017930 ATP binding site [chemical binding]; other site 1278073017931 Walker B motif; other site 1278073017932 arginine finger; other site 1278073017933 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1278073017934 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073017935 active site 1278073017936 ATP binding site [chemical binding]; other site 1278073017937 substrate binding site [chemical binding]; other site 1278073017938 activation loop (A-loop); other site 1278073017939 PEGA domain; Region: PEGA; pfam08308 1278073017940 FtsX-like permease family; Region: FtsX; pfam02687 1278073017941 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1278073017942 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1278073017943 Walker A/P-loop; other site 1278073017944 ATP binding site [chemical binding]; other site 1278073017945 Q-loop/lid; other site 1278073017946 ABC transporter signature motif; other site 1278073017947 Walker B; other site 1278073017948 D-loop; other site 1278073017949 H-loop/switch region; other site 1278073017950 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1278073017951 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1278073017952 PspA/IM30 family; Region: PspA_IM30; pfam04012 1278073017953 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073017954 pinin/SDK/memA/ protein conserved region; Region: Pinin_SDK_memA; pfam04696 1278073017955 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073017956 dimer interface [polypeptide binding]; other site 1278073017957 phosphorylation site [posttranslational modification] 1278073017958 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073017959 ATP binding site [chemical binding]; other site 1278073017960 Mg2+ binding site [ion binding]; other site 1278073017961 G-X-G motif; other site 1278073017962 N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228 1278073017963 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1278073017964 active site 1278073017965 putative substrate binding pocket [chemical binding]; other site 1278073017966 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1278073017967 active site 1278073017968 catalytic motif [active] 1278073017969 Zn binding site [ion binding]; other site 1278073017970 PilZ domain; Region: PilZ; cl01260 1278073017971 SET domain; Region: SET; pfam00856 1278073017972 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1278073017973 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1278073017974 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1278073017975 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073017976 NAD(P) binding site [chemical binding]; other site 1278073017977 active site 1278073017978 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 1278073017979 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1278073017980 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1278073017981 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 1278073017982 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1278073017983 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1278073017984 ligand binding site [chemical binding]; other site 1278073017985 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1278073017986 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1278073017987 Walker A/P-loop; other site 1278073017988 ATP binding site [chemical binding]; other site 1278073017989 Q-loop/lid; other site 1278073017990 ABC transporter signature motif; other site 1278073017991 Walker B; other site 1278073017992 D-loop; other site 1278073017993 H-loop/switch region; other site 1278073017994 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1278073017995 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1278073017996 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1278073017997 TM-ABC transporter signature motif; other site 1278073017998 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1278073017999 TM-ABC transporter signature motif; other site 1278073018000 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073018001 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073018002 active site 1278073018003 phosphorylation site [posttranslational modification] 1278073018004 intermolecular recognition site; other site 1278073018005 dimerization interface [polypeptide binding]; other site 1278073018006 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073018007 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073018008 ATP binding site [chemical binding]; other site 1278073018009 Mg2+ binding site [ion binding]; other site 1278073018010 G-X-G motif; other site 1278073018011 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1278073018012 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1278073018013 active site 1278073018014 substrate binding site [chemical binding]; other site 1278073018015 metal binding site [ion binding]; metal-binding site 1278073018016 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1278073018017 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1278073018018 intersubunit interface [polypeptide binding]; other site 1278073018019 active site 1278073018020 catalytic residue [active] 1278073018021 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1278073018022 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1278073018023 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1278073018024 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1278073018025 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 1278073018026 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 1278073018027 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 1278073018028 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 1278073018029 TIGR02300 family protein; Region: FYDLN_acid 1278073018030 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1278073018031 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1278073018032 Putative zinc ribbon domain; Region: DUF164; pfam02591 1278073018033 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 1278073018034 RNA/DNA hybrid binding site [nucleotide binding]; other site 1278073018035 active site 1278073018036 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1278073018037 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1278073018038 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1278073018039 GTP binding site [chemical binding]; other site 1278073018040 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1278073018041 Zn binding site [ion binding]; other site 1278073018042 PEGA domain; Region: PEGA; pfam08308 1278073018043 Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex; Region: CESA_CaSu_A2; cd06437 1278073018044 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1278073018045 DXD motif; other site 1278073018046 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1278073018047 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1278073018048 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1278073018049 PEGA domain; Region: PEGA; pfam08308 1278073018050 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 1278073018051 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1278073018052 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1278073018053 protein binding site [polypeptide binding]; other site 1278073018054 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1278073018055 Catalytic dyad [active] 1278073018056 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1278073018057 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 1278073018058 Peptidase family M23; Region: Peptidase_M23; pfam01551 1278073018059 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1278073018060 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1278073018061 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1278073018062 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073018063 Walker A/P-loop; other site 1278073018064 ATP binding site [chemical binding]; other site 1278073018065 Q-loop/lid; other site 1278073018066 ABC transporter signature motif; other site 1278073018067 Walker B; other site 1278073018068 D-loop; other site 1278073018069 H-loop/switch region; other site 1278073018070 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1278073018071 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1278073018072 transmembrane helices; other site 1278073018073 Kua-ubiquitin conjugating enzyme hybrid localisation domain; Region: Kua-UEV1_localn; pfam10520 1278073018074 glutamate racemase; Provisional; Region: PRK00865 1278073018075 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1278073018076 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1278073018077 TolR protein; Region: tolR; TIGR02801 1278073018078 TolA protein; Region: tolA_full; TIGR02794 1278073018079 TonB C terminal; Region: TonB_2; pfam13103 1278073018080 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 1278073018081 TolB amino-terminal domain; Region: TolB_N; pfam04052 1278073018082 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1278073018083 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1278073018084 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1278073018085 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1278073018086 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1278073018087 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1278073018088 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1278073018089 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1278073018090 catalytic residue [active] 1278073018091 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1278073018092 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1278073018093 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1278073018094 D-galactonate transporter; Region: 2A0114; TIGR00893 1278073018095 putative substrate translocation pore; other site 1278073018096 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1278073018097 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Region: LPLAT_AAK14816-like; cd07992 1278073018098 putative acyl-acceptor binding pocket; other site 1278073018099 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 1278073018100 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1278073018101 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1278073018102 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1278073018103 Surface antigen; Region: Bac_surface_Ag; pfam01103 1278073018104 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1278073018105 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1278073018106 Family of unknown function (DUF490); Region: DUF490; pfam04357 1278073018107 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 1278073018108 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073018109 Walker A motif; other site 1278073018110 ATP binding site [chemical binding]; other site 1278073018111 Walker B motif; other site 1278073018112 arginine finger; other site 1278073018113 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073018114 binding surface 1278073018115 TPR motif; other site 1278073018116 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073018117 TPR motif; other site 1278073018118 binding surface 1278073018119 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1278073018120 TPR motif; other site 1278073018121 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1278073018122 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1278073018123 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1278073018124 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1278073018125 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1278073018126 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1278073018127 carboxyltransferase (CT) interaction site; other site 1278073018128 biotinylation site [posttranslational modification]; other site 1278073018129 elongation factor P; Validated; Region: PRK00529 1278073018130 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1278073018131 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1278073018132 RNA binding site [nucleotide binding]; other site 1278073018133 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1278073018134 RNA binding site [nucleotide binding]; other site 1278073018135 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 1278073018136 AMIN domain; Region: AMIN; pfam11741 1278073018137 AMIN domain; Region: AMIN; pfam11741 1278073018138 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 1278073018139 Secretin and TonB N terminus short domain; Region: STN; smart00965 1278073018140 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1278073018141 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1278073018142 Pilus assembly protein, PilP; Region: PilP; pfam04351 1278073018143 Pilus assembly protein, PilO; Region: PilO; cl01234 1278073018144 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 1278073018145 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1278073018146 Competence protein A; Region: Competence_A; pfam11104 1278073018147 Cell division protein FtsA; Region: FtsA; cl17206 1278073018148 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1278073018149 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1278073018150 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073018151 active site 1278073018152 phosphorylation site [posttranslational modification] 1278073018153 intermolecular recognition site; other site 1278073018154 dimerization interface [polypeptide binding]; other site 1278073018155 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073018156 Walker A motif; other site 1278073018157 ATP binding site [chemical binding]; other site 1278073018158 Walker B motif; other site 1278073018159 arginine finger; other site 1278073018160 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1278073018161 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073018162 dimer interface [polypeptide binding]; other site 1278073018163 phosphorylation site [posttranslational modification] 1278073018164 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073018165 ATP binding site [chemical binding]; other site 1278073018166 G-X-G motif; other site 1278073018167 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1278073018168 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1278073018169 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1278073018170 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1278073018171 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 1278073018172 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1278073018173 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1278073018174 Walker A/P-loop; other site 1278073018175 ATP binding site [chemical binding]; other site 1278073018176 Q-loop/lid; other site 1278073018177 ABC transporter signature motif; other site 1278073018178 Walker B; other site 1278073018179 D-loop; other site 1278073018180 H-loop/switch region; other site 1278073018181 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1278073018182 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 1278073018183 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073018184 binding surface 1278073018185 TPR motif; other site 1278073018186 TPR repeat; Region: TPR_11; pfam13414 1278073018187 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1278073018188 WbqC-like protein family; Region: WbqC; pfam08889 1278073018189 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1278073018190 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1278073018191 inhibitor-cofactor binding pocket; inhibition site 1278073018192 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1278073018193 catalytic residue [active] 1278073018194 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1278073018195 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1278073018196 Ligand binding site; other site 1278073018197 Putative Catalytic site; other site 1278073018198 DXD motif; other site 1278073018199 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1278073018200 hypothetical protein; Provisional; Region: PRK07208 1278073018201 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1278073018202 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1278073018203 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073018204 active site 1278073018205 phosphorylation site [posttranslational modification] 1278073018206 intermolecular recognition site; other site 1278073018207 dimerization interface [polypeptide binding]; other site 1278073018208 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073018209 Walker A motif; other site 1278073018210 ATP binding site [chemical binding]; other site 1278073018211 Walker B motif; other site 1278073018212 arginine finger; other site 1278073018213 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1278073018214 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1278073018215 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1278073018216 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073018217 phosphorylation site [posttranslational modification] 1278073018218 dimer interface [polypeptide binding]; other site 1278073018219 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073018220 ATP binding site [chemical binding]; other site 1278073018221 Mg2+ binding site [ion binding]; other site 1278073018222 G-X-G motif; other site 1278073018223 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1278073018224 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1278073018225 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1278073018226 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 1278073018227 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1278073018228 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 1278073018229 Walker A motif; other site 1278073018230 ATP binding site [chemical binding]; other site 1278073018231 Walker B motif; other site 1278073018232 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 1278073018233 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1278073018234 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1278073018235 Walker A motif; other site 1278073018236 ATP binding site [chemical binding]; other site 1278073018237 Walker B motif; other site 1278073018238 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1278073018239 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1278073018240 active site 1278073018241 Riboflavin kinase; Region: Flavokinase; pfam01687 1278073018242 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073018243 S-adenosylmethionine binding site [chemical binding]; other site 1278073018244 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073018245 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073018246 active site 1278073018247 phosphorylation site [posttranslational modification] 1278073018248 intermolecular recognition site; other site 1278073018249 dimerization interface [polypeptide binding]; other site 1278073018250 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1278073018251 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1278073018252 metal binding site [ion binding]; metal-binding site 1278073018253 active site 1278073018254 I-site; other site 1278073018255 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1278073018256 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 1278073018257 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1278073018258 active site 1278073018259 catalytic site [active] 1278073018260 substrate binding site [chemical binding]; other site 1278073018261 CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460 1278073018262 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1278073018263 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1278073018264 putative active site [active] 1278073018265 sensory histidine kinase CreC; Provisional; Region: PRK11100 1278073018266 HEAT repeats; Region: HEAT_2; pfam13646 1278073018267 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1278073018268 putative CoA binding site [chemical binding]; other site 1278073018269 putative trimer interface [polypeptide binding]; other site 1278073018270 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1278073018271 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1278073018272 motif 1; other site 1278073018273 active site 1278073018274 motif 2; other site 1278073018275 motif 3; other site 1278073018276 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1278073018277 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1278073018278 Myxococcus xanthus paralogous domain TIGR02266; Region: gmx_TIGR02266 1278073018279 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 1278073018280 nucleotide binding site [chemical binding]; other site 1278073018281 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1278073018282 SBD interface [polypeptide binding]; other site 1278073018283 glutamate--cysteine ligase; Region: PLN02611 1278073018284 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 1278073018285 putative carboxyl-terminal-processing protease, deltaproteobacterial; Region: prc_long_Delta; TIGR03900 1278073018286 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1278073018287 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1278073018288 protein binding site [polypeptide binding]; other site 1278073018289 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1278073018290 Catalytic dyad [active] 1278073018291 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1278073018292 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1278073018293 active site 1278073018294 catalytic site [active] 1278073018295 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1278073018296 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 1278073018297 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 1278073018298 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1278073018299 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1278073018300 P-loop; other site 1278073018301 Magnesium ion binding site [ion binding]; other site 1278073018302 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1278073018303 Magnesium ion binding site [ion binding]; other site 1278073018304 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 1278073018305 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1278073018306 DTAP/Switch II; other site 1278073018307 Switch I; other site 1278073018308 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1278073018309 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1278073018310 P loop; other site 1278073018311 Nucleotide binding site [chemical binding]; other site 1278073018312 DTAP/Switch II; other site 1278073018313 Switch I; other site 1278073018314 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1278073018315 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073018316 binding surface 1278073018317 TPR motif; other site 1278073018318 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1278073018319 Peptidase family M48; Region: Peptidase_M48; cl12018 1278073018320 TPR repeat; Region: TPR_11; pfam13414 1278073018321 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073018322 TPR motif; other site 1278073018323 binding surface 1278073018324 TPR repeat; Region: TPR_11; pfam13414 1278073018325 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 1278073018326 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1278073018327 PrkA AAA domain; Region: AAA_PrkA; smart00763 1278073018328 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1278073018329 hypothetical protein; Provisional; Region: PRK05325 1278073018330 SpoVR like protein; Region: SpoVR; pfam04293 1278073018331 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1278073018332 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073018333 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073018334 active site 1278073018335 ATP binding site [chemical binding]; other site 1278073018336 substrate binding site [chemical binding]; other site 1278073018337 activation loop (A-loop); other site 1278073018338 RNA polymerase sigma-70 factor, Myxococcales family 1; Region: Sig-70_gmx1; TIGR03001 1278073018339 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1278073018340 DNA binding residues [nucleotide binding] 1278073018341 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1278073018342 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1278073018343 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 1278073018344 calcium binding site 2 [ion binding]; other site 1278073018345 active site 1278073018346 catalytic triad [active] 1278073018347 calcium binding site 1 [ion binding]; other site 1278073018348 Somatomedin B domain; Region: Somatomedin_B; pfam01033 1278073018349 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1278073018350 protein-splicing catalytic site; other site 1278073018351 thioester formation/cholesterol transfer; other site 1278073018352 PGAP1-like protein; Region: PGAP1; pfam07819 1278073018353 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 1278073018354 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1278073018355 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 1278073018356 PA/protease or protease-like domain interface [polypeptide binding]; other site 1278073018357 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 1278073018358 Zn binding site [ion binding]; other site 1278073018359 Peptidase family M23; Region: Peptidase_M23; pfam01551 1278073018360 Protein of unknown function (DUF2378); Region: DUF2378; pfam09536 1278073018361 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1278073018362 homodimer interface [polypeptide binding]; other site 1278073018363 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1278073018364 active site pocket [active] 1278073018365 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1278073018366 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1278073018367 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1278073018368 Walker A/P-loop; other site 1278073018369 ATP binding site [chemical binding]; other site 1278073018370 Q-loop/lid; other site 1278073018371 ABC transporter signature motif; other site 1278073018372 Walker B; other site 1278073018373 D-loop; other site 1278073018374 H-loop/switch region; other site 1278073018375 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1278073018376 ABC-ATPase subunit interface; other site 1278073018377 dimer interface [polypeptide binding]; other site 1278073018378 putative PBP binding regions; other site 1278073018379 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1278073018380 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1278073018381 ABC-ATPase subunit interface; other site 1278073018382 dimer interface [polypeptide binding]; other site 1278073018383 putative PBP binding regions; other site 1278073018384 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1278073018385 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1278073018386 putative ligand binding residues [chemical binding]; other site 1278073018387 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1278073018388 Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin; Region: M3A_TOP; cd06455 1278073018389 active site 1278073018390 Zn binding site [ion binding]; other site 1278073018391 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 1278073018392 Fibronectin type 3 domain; Region: FN3; smart00060 1278073018393 short chain dehydrogenase; Provisional; Region: PRK07576 1278073018394 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 1278073018395 NAD(P) binding site [chemical binding]; other site 1278073018396 substrate binding site [chemical binding]; other site 1278073018397 homotetramer interface [polypeptide binding]; other site 1278073018398 active site 1278073018399 homodimer interface [polypeptide binding]; other site 1278073018400 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1278073018401 Peptidase family U32; Region: Peptidase_U32; pfam01136 1278073018402 Collagenase; Region: DUF3656; pfam12392 1278073018403 Peptidase family U32; Region: Peptidase_U32; cl03113 1278073018404 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 1278073018405 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain; Region: 2-Hacid_dh_C; pfam02826 1278073018406 prephenate dehydrogenase; Validated; Region: PRK08507 1278073018407 Chorismate mutase type II; Region: CM_2; smart00830 1278073018408 enoyl-CoA hydratase; Provisional; Region: PRK06142 1278073018409 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1278073018410 substrate binding site [chemical binding]; other site 1278073018411 oxyanion hole (OAH) forming residues; other site 1278073018412 trimer interface [polypeptide binding]; other site 1278073018413 Protein of unknown function (Gmx_para_CXXCG); Region: Gmx_para_CXXCG; pfam09535 1278073018414 Predicted lipoprotein of unknown function (DUF2380); Region: DUF2380; cl15289 1278073018415 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1278073018416 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1278073018417 active site 1278073018418 PHP Thumb interface [polypeptide binding]; other site 1278073018419 metal binding site [ion binding]; metal-binding site 1278073018420 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1278073018421 generic binding surface II; other site 1278073018422 generic binding surface I; other site 1278073018423 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1278073018424 dimer interface [polypeptide binding]; other site 1278073018425 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1278073018426 active site 1278073018427 Zn binding site [ion binding]; other site 1278073018428 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 1278073018429 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1278073018430 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1278073018431 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073018432 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1278073018433 DNA binding residues [nucleotide binding] 1278073018434 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 1278073018435 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1278073018436 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1278073018437 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 1278073018438 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1278073018439 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073018440 NAD(P) binding site [chemical binding]; other site 1278073018441 active site 1278073018442 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 1278073018443 Sterol carrier protein domain; Region: SCP2_2; pfam13530 1278073018444 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1278073018445 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1278073018446 phosphopeptide binding site; other site 1278073018447 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1278073018448 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1278073018449 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1278073018450 Walker A motif; other site 1278073018451 ATP binding site [chemical binding]; other site 1278073018452 Walker B motif; other site 1278073018453 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1278073018454 PAS domain; Region: PAS; smart00091 1278073018455 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1278073018456 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073018457 dimer interface [polypeptide binding]; other site 1278073018458 phosphorylation site [posttranslational modification] 1278073018459 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073018460 ATP binding site [chemical binding]; other site 1278073018461 Mg2+ binding site [ion binding]; other site 1278073018462 G-X-G motif; other site 1278073018463 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1278073018464 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073018465 active site 1278073018466 phosphorylation site [posttranslational modification] 1278073018467 intermolecular recognition site; other site 1278073018468 dimerization interface [polypeptide binding]; other site 1278073018469 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073018470 Walker A motif; other site 1278073018471 ATP binding site [chemical binding]; other site 1278073018472 Walker B motif; other site 1278073018473 arginine finger; other site 1278073018474 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 1278073018475 acetyl-CoA synthetase; Provisional; Region: PRK00174 1278073018476 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1278073018477 active site 1278073018478 CoA binding site [chemical binding]; other site 1278073018479 acyl-activating enzyme (AAE) consensus motif; other site 1278073018480 AMP binding site [chemical binding]; other site 1278073018481 acetate binding site [chemical binding]; other site 1278073018482 Protein of unknown function, DUF485; Region: DUF485; pfam04341 1278073018483 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1278073018484 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1278073018485 Na binding site [ion binding]; other site 1278073018486 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1278073018487 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073018488 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1278073018489 DNA binding residues [nucleotide binding] 1278073018490 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 1278073018491 Predicted transporter component [General function prediction only]; Region: COG2391 1278073018492 Predicted transporter component [General function prediction only]; Region: COG2391 1278073018493 Sulphur transport; Region: Sulf_transp; pfam04143 1278073018494 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1278073018495 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073018496 S-adenosylmethionine binding site [chemical binding]; other site 1278073018497 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 1278073018498 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1278073018499 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1278073018500 E-class dimer interface [polypeptide binding]; other site 1278073018501 P-class dimer interface [polypeptide binding]; other site 1278073018502 active site 1278073018503 Cu2+ binding site [ion binding]; other site 1278073018504 Zn2+ binding site [ion binding]; other site 1278073018505 Beta-lactamase; Region: Beta-lactamase; pfam00144 1278073018506 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1278073018507 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 1278073018508 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1278073018509 metal ion-dependent adhesion site (MIDAS); other site 1278073018510 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 1278073018511 Filamin/ABP280 repeat; Region: Filamin; pfam00630 1278073018512 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 1278073018513 Farnesoic acid 0-methyl transferase; Region: Methyltransf_FA; pfam12248 1278073018514 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1278073018515 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1278073018516 active site 1278073018517 alternative sigma factor RpoH; Region: rpoH_proteo; TIGR02392 1278073018518 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073018519 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1278073018520 DNA binding residues [nucleotide binding] 1278073018521 helicase 45; Provisional; Region: PTZ00424 1278073018522 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1278073018523 ATP binding site [chemical binding]; other site 1278073018524 Mg++ binding site [ion binding]; other site 1278073018525 motif III; other site 1278073018526 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1278073018527 nucleotide binding region [chemical binding]; other site 1278073018528 ATP-binding site [chemical binding]; other site 1278073018529 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 1278073018530 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1278073018531 sequence-specific DNA binding site [nucleotide binding]; other site 1278073018532 salt bridge; other site 1278073018533 glutamate dehydrogenase; Region: PLN02477 1278073018534 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1278073018535 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1278073018536 NAD(P) binding site [chemical binding]; other site 1278073018537 threonine dehydratase; Provisional; Region: PRK08198 1278073018538 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1278073018539 tetramer interface [polypeptide binding]; other site 1278073018540 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1278073018541 catalytic residue [active] 1278073018542 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 1278073018543 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1278073018544 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 1278073018545 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 1278073018546 Uncharacterized conserved protein [Function unknown]; Region: COG2353 1278073018547 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1278073018548 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1278073018549 putative active site [active] 1278073018550 metal binding site [ion binding]; metal-binding site 1278073018551 Activator of aromatic catabolism; Region: XylR_N; pfam06505 1278073018552 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 1278073018553 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1278073018554 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073018555 Walker A motif; other site 1278073018556 ATP binding site [chemical binding]; other site 1278073018557 Walker B motif; other site 1278073018558 arginine finger; other site 1278073018559 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1278073018560 Eukaryotic integral membrane protein (DUF1751); Region: DUF1751; pfam08551 1278073018561 putative acyltransferase; Provisional; Region: PRK05790 1278073018562 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1278073018563 dimer interface [polypeptide binding]; other site 1278073018564 active site 1278073018565 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 1278073018566 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 1278073018567 putative catalytic residue [active] 1278073018568 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073018569 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073018570 active site 1278073018571 ATP binding site [chemical binding]; other site 1278073018572 substrate binding site [chemical binding]; other site 1278073018573 activation loop (A-loop); other site 1278073018574 AAA ATPase domain; Region: AAA_16; pfam13191 1278073018575 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1278073018576 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073018577 active site 1278073018578 phosphorylation site [posttranslational modification] 1278073018579 intermolecular recognition site; other site 1278073018580 dimerization interface [polypeptide binding]; other site 1278073018581 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 1278073018582 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 1278073018583 Glutamate binding site [chemical binding]; other site 1278073018584 NAD binding site [chemical binding]; other site 1278073018585 catalytic residues [active] 1278073018586 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 1278073018587 active site 1278073018588 catalytic residues [active] 1278073018589 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1278073018590 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1278073018591 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1278073018592 substrate binding pocket [chemical binding]; other site 1278073018593 dimerization interface [polypeptide binding]; other site 1278073018594 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1278073018595 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1278073018596 active site 1278073018597 Phosphotransferase enzyme family; Region: APH; pfam01636 1278073018598 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 1278073018599 putative active site [active] 1278073018600 putative substrate binding site [chemical binding]; other site 1278073018601 ATP binding site [chemical binding]; other site 1278073018602 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1278073018603 catalytic core [active] 1278073018604 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1278073018605 catalytic core [active] 1278073018606 short chain dehydrogenase; Provisional; Region: PRK08251 1278073018607 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073018608 NAD(P) binding site [chemical binding]; other site 1278073018609 active site 1278073018610 Dienelactone hydrolase family; Region: DLH; pfam01738 1278073018611 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1278073018612 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1278073018613 Helix-turn-helix domain; Region: HTH_18; pfam12833 1278073018614 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1278073018615 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1278073018616 DNA binding site [nucleotide binding] 1278073018617 active site 1278073018618 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1278073018619 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 1278073018620 putative C-terminal domain interface [polypeptide binding]; other site 1278073018621 putative GSH binding site (G-site) [chemical binding]; other site 1278073018622 putative dimer interface [polypeptide binding]; other site 1278073018623 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1278073018624 N-terminal domain interface [polypeptide binding]; other site 1278073018625 dimer interface [polypeptide binding]; other site 1278073018626 substrate binding pocket (H-site) [chemical binding]; other site 1278073018627 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1278073018628 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1278073018629 TrkA-N domain; Region: TrkA_N; pfam02254 1278073018630 TrkA-C domain; Region: TrkA_C; pfam02080 1278073018631 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 1278073018632 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 1278073018633 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 1278073018634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1278073018635 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1278073018636 putative substrate translocation pore; other site 1278073018637 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1278073018638 dimerization interface [polypeptide binding]; other site 1278073018639 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1278073018640 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1278073018641 dimer interface [polypeptide binding]; other site 1278073018642 putative CheW interface [polypeptide binding]; other site 1278073018643 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1278073018644 dimer interface [polypeptide binding]; other site 1278073018645 putative CheW interface [polypeptide binding]; other site 1278073018646 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1278073018647 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 1278073018648 active site 1278073018649 Zn binding site [ion binding]; other site 1278073018650 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1278073018651 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 1278073018652 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1278073018653 Sulfatase; Region: Sulfatase; pfam00884 1278073018654 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1278073018655 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073018656 NAD(P) binding site [chemical binding]; other site 1278073018657 active site 1278073018658 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1278073018659 active site 1278073018660 dimer interface [polypeptide binding]; other site 1278073018661 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 1278073018662 Transglycosylase; Region: Transgly; pfam00912 1278073018663 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1278073018664 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1278073018665 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1278073018666 RNA binding surface [nucleotide binding]; other site 1278073018667 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1278073018668 active site 1278073018669 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1278073018670 Pentapeptide repeats (9 copies); Region: Pentapeptide_3; pfam13576 1278073018671 MOSC domain; Region: MOSC; pfam03473 1278073018672 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 1278073018673 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1278073018674 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1278073018675 EamA-like transporter family; Region: EamA; pfam00892 1278073018676 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1278073018677 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1278073018678 Coenzyme A binding pocket [chemical binding]; other site 1278073018679 Cytochrome oxidase complex assembly protein 1; Region: Coa1; pfam08695 1278073018680 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1278073018681 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 1278073018682 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1278073018683 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1278073018684 Ligand binding site [chemical binding]; other site 1278073018685 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1278073018686 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1278073018687 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1278073018688 active site 1278073018689 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1278073018690 active site 1278073018691 intersubunit interactions; other site 1278073018692 catalytic residue [active] 1278073018693 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 1278073018694 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1278073018695 putative active site [active] 1278073018696 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1278073018697 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073018698 binding surface 1278073018699 TPR motif; other site 1278073018700 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1278073018701 catalytic center binding site [active] 1278073018702 ATP binding site [chemical binding]; other site 1278073018703 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1278073018704 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1278073018705 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1278073018706 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1278073018707 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1278073018708 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1278073018709 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1278073018710 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1278073018711 dimer interface [polypeptide binding]; other site 1278073018712 active site 1278073018713 catalytic residue [active] 1278073018714 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1278073018715 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1278073018716 active site 1278073018717 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1278073018718 substrate binding site [chemical binding]; other site 1278073018719 catalytic residues [active] 1278073018720 dimer interface [polypeptide binding]; other site 1278073018721 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1278073018722 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1278073018723 DNA binding site [nucleotide binding] 1278073018724 catalytic residue [active] 1278073018725 H2TH interface [polypeptide binding]; other site 1278073018726 putative catalytic residues [active] 1278073018727 turnover-facilitating residue; other site 1278073018728 intercalation triad [nucleotide binding]; other site 1278073018729 8OG recognition residue [nucleotide binding]; other site 1278073018730 putative reading head residues; other site 1278073018731 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1278073018732 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1278073018733 Ku-core domain; includes the central DNA-binding beta-barrels, polypeptide rings, and the C-terminal arm of Ku proteins. The Ku protein consists of two tightly associated homologous subunits, Ku70 and Ku80, and was originally identified as an autoantigen...; Region: KU; cl02666 1278073018734 DNA binding site [nucleotide binding] 1278073018735 heterodimer interface [polypeptide binding]; other site 1278073018736 Peptidase family M48; Region: Peptidase_M48; pfam01435 1278073018737 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1278073018738 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1278073018739 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1278073018740 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1278073018741 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1278073018742 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 1278073018743 TM1410 hypothetical-related protein; Region: DUF297; cl00997 1278073018744 EamA-like transporter family; Region: EamA; pfam00892 1278073018745 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1278073018746 EamA-like transporter family; Region: EamA; pfam00892 1278073018747 epoxyqueuosine reductase; Region: TIGR00276 1278073018748 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1278073018749 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 1278073018750 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1278073018751 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1278073018752 dimerization interface [polypeptide binding]; other site 1278073018753 active site 1278073018754 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1278073018755 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1278073018756 folate binding site [chemical binding]; other site 1278073018757 NADP+ binding site [chemical binding]; other site 1278073018758 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1278073018759 Cytochrome c; Region: Cytochrom_C; pfam00034 1278073018760 Iron permease FTR1 family; Region: FTR1; cl00475 1278073018761 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1278073018762 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1278073018763 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1278073018764 Zn2+ binding site [ion binding]; other site 1278073018765 Mg2+ binding site [ion binding]; other site 1278073018766 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1278073018767 putative acetyltransferase; Provisional; Region: PRK03624 1278073018768 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1278073018769 Coenzyme A binding pocket [chemical binding]; other site 1278073018770 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1278073018771 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1278073018772 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1278073018773 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1278073018774 catalytic residues [active] 1278073018775 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1278073018776 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1278073018777 tRNAHis guanylyltransferase; Region: Thg1; pfam04446 1278073018778 Uncharacterized conserved protein [Function unknown]; Region: COG4021 1278073018779 Thg1 C terminal domain; Region: Thg1C; pfam14413 1278073018780 AAA domain; Region: AAA_33; pfam13671 1278073018781 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1278073018782 active site 1278073018783 catalytic residues [active] 1278073018784 AAA domain; Region: AAA_11; pfam13086 1278073018785 AAA domain; Region: AAA_30; pfam13604 1278073018786 AAA domain; Region: AAA_12; pfam13087 1278073018787 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1278073018788 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1278073018789 catalytic site [active] 1278073018790 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1278073018791 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073018792 active site 1278073018793 ATP binding site [chemical binding]; other site 1278073018794 substrate binding site [chemical binding]; other site 1278073018795 activation loop (A-loop); other site 1278073018796 Uncharacterized conserved protein [Function unknown]; Region: COG3791 1278073018797 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1278073018798 tellurite resistance protein terB; Region: terB; cd07176 1278073018799 putative metal binding site [ion binding]; other site 1278073018800 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1278073018801 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1278073018802 Ligand Binding Site [chemical binding]; other site 1278073018803 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1278073018804 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1278073018805 catalytic site [active] 1278073018806 putative active site [active] 1278073018807 putative substrate binding site [chemical binding]; other site 1278073018808 HRDC domain; Region: HRDC; pfam00570 1278073018809 HRDC domain; Region: HRDC; pfam00570 1278073018810 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 1278073018811 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 1278073018812 Zn binding site [ion binding]; other site 1278073018813 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1278073018814 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073018815 S-adenosylmethionine binding site [chemical binding]; other site 1278073018816 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 1278073018817 dimerization interface [polypeptide binding]; other site 1278073018818 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1278073018819 Beta-lactamase; Region: Beta-lactamase; pfam00144 1278073018820 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1278073018821 Transposase; Region: HTH_Tnp_1; pfam01527 1278073018822 MULE transposase domain; Region: MULE; pfam10551 1278073018823 HTH-like domain; Region: HTH_21; pfam13276 1278073018824 Integrase core domain; Region: rve; pfam00665 1278073018825 Integrase core domain; Region: rve_3; pfam13683 1278073018826 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1278073018827 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1278073018828 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 1278073018829 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 1278073018830 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1278073018831 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 1278073018832 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 1278073018833 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1278073018834 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1278073018835 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1278073018836 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1278073018837 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1278073018838 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1278073018839 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1278073018840 Transposase; Region: HTH_Tnp_1; pfam01527 1278073018841 HTH-like domain; Region: HTH_21; pfam13276 1278073018842 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1278073018843 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1278073018844 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1278073018845 Winged helix-turn helix; Region: HTH_29; pfam13551 1278073018846 Homeodomain-like domain; Region: HTH_32; pfam13565 1278073018847 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 1278073018848 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 1278073018849 active site 1278073018850 Zn binding site [ion binding]; other site 1278073018851 short chain dehydrogenase; Provisional; Region: PRK12937 1278073018852 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 1278073018853 NADP binding site [chemical binding]; other site 1278073018854 homodimer interface [polypeptide binding]; other site 1278073018855 active site 1278073018856 substrate binding site [chemical binding]; other site 1278073018857 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1278073018858 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1278073018859 G1 box; other site 1278073018860 putative GEF interaction site [polypeptide binding]; other site 1278073018861 GTP/Mg2+ binding site [chemical binding]; other site 1278073018862 Switch I region; other site 1278073018863 G2 box; other site 1278073018864 G3 box; other site 1278073018865 Switch II region; other site 1278073018866 G4 box; other site 1278073018867 G5 box; other site 1278073018868 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1278073018869 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 1278073018870 homotrimer interaction site [polypeptide binding]; other site 1278073018871 putative active site [active] 1278073018872 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1278073018873 Putative addiction module component; Region: Unstab_antitox; cl09921 1278073018874 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1278073018875 Kelch domain; Region: Kelch; smart00612 1278073018876 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1278073018877 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 1278073018878 Kelch motif; Region: Kelch_1; pfam01344 1278073018879 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1278073018880 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1278073018881 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1278073018882 Kelch domain; Region: Kelch; smart00612 1278073018883 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1278073018884 Kelch domain; Region: Kelch; smart00612 1278073018885 Kelch domain; Region: Kelch; smart00612 1278073018886 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1278073018887 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 1278073018888 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1278073018889 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 1278073018890 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073018891 Walker A/P-loop; other site 1278073018892 ATP binding site [chemical binding]; other site 1278073018893 Q-loop/lid; other site 1278073018894 ABC transporter signature motif; other site 1278073018895 Walker B; other site 1278073018896 D-loop; other site 1278073018897 H-loop/switch region; other site 1278073018898 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073018899 S-adenosylmethionine binding site [chemical binding]; other site 1278073018900 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 1278073018901 TAP-like protein; Region: Abhydrolase_4; pfam08386 1278073018902 Peptidase family M23; Region: Peptidase_M23; pfam01551 1278073018903 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1278073018904 hypothetical protein; Provisional; Region: PRK07907 1278073018905 active site 1278073018906 metal binding site [ion binding]; metal-binding site 1278073018907 dimer interface [polypeptide binding]; other site 1278073018908 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073018909 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073018910 active site 1278073018911 phosphorylation site [posttranslational modification] 1278073018912 intermolecular recognition site; other site 1278073018913 dimerization interface [polypeptide binding]; other site 1278073018914 Myxococcus xanthus paralogous domain TIGR02266; Region: gmx_TIGR02266 1278073018915 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073018916 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073018917 dimer interface [polypeptide binding]; other site 1278073018918 phosphorylation site [posttranslational modification] 1278073018919 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073018920 ATP binding site [chemical binding]; other site 1278073018921 Mg2+ binding site [ion binding]; other site 1278073018922 G-X-G motif; other site 1278073018923 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1278073018924 FAD binding pocket [chemical binding]; other site 1278073018925 conserved FAD binding motif [chemical binding]; other site 1278073018926 phosphate binding motif [ion binding]; other site 1278073018927 beta-alpha-beta structure motif; other site 1278073018928 NAD binding pocket [chemical binding]; other site 1278073018929 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1278073018930 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1278073018931 putative acyl-acceptor binding pocket; other site 1278073018932 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1278073018933 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1278073018934 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1278073018935 amino acid transporter; Region: 2A0306; TIGR00909 1278073018936 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1278073018937 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1278073018938 active site 1278073018939 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 1278073018940 Methyltransferase domain; Region: Methyltransf_32; pfam13679 1278073018941 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 1278073018942 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1278073018943 Protein of unknown function (DUF2378); Region: DUF2378; pfam09536 1278073018944 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 1278073018945 Protein of unknown function, DUF482; Region: DUF482; pfam04339 1278073018946 Uncharacterized conserved protein [Function unknown]; Region: COG2127 1278073018947 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 1278073018948 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073018949 Walker A motif; other site 1278073018950 ATP binding site [chemical binding]; other site 1278073018951 Walker B motif; other site 1278073018952 arginine finger; other site 1278073018953 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073018954 Walker A motif; other site 1278073018955 ATP binding site [chemical binding]; other site 1278073018956 Walker B motif; other site 1278073018957 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1278073018958 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1278073018959 dimerization interface [polypeptide binding]; other site 1278073018960 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1278073018961 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1278073018962 dimer interface [polypeptide binding]; other site 1278073018963 putative CheW interface [polypeptide binding]; other site 1278073018964 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 1278073018965 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073018966 active site 1278073018967 phosphorylation site [posttranslational modification] 1278073018968 intermolecular recognition site; other site 1278073018969 dimerization interface [polypeptide binding]; other site 1278073018970 CheB methylesterase; Region: CheB_methylest; pfam01339 1278073018971 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1278073018972 putative binding surface; other site 1278073018973 active site 1278073018974 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073018975 ATP binding site [chemical binding]; other site 1278073018976 Mg2+ binding site [ion binding]; other site 1278073018977 G-X-G motif; other site 1278073018978 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1278073018979 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073018980 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073018981 active site 1278073018982 phosphorylation site [posttranslational modification] 1278073018983 intermolecular recognition site; other site 1278073018984 CheW-like domain; Region: CheW; pfam01584 1278073018985 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1278073018986 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073018987 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073018988 active site 1278073018989 phosphorylation site [posttranslational modification] 1278073018990 intermolecular recognition site; other site 1278073018991 dimerization interface [polypeptide binding]; other site 1278073018992 CheW-like domain; Region: CheW; pfam01584 1278073018993 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073018994 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073018995 active site 1278073018996 phosphorylation site [posttranslational modification] 1278073018997 intermolecular recognition site; other site 1278073018998 dimerization interface [polypeptide binding]; other site 1278073018999 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 1278073019000 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1278073019001 NAD binding site [chemical binding]; other site 1278073019002 homotetramer interface [polypeptide binding]; other site 1278073019003 homodimer interface [polypeptide binding]; other site 1278073019004 substrate binding site [chemical binding]; other site 1278073019005 active site 1278073019006 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1278073019007 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1278073019008 TPP-binding site [chemical binding]; other site 1278073019009 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1278073019010 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1278073019011 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1278073019012 E3 interaction surface; other site 1278073019013 lipoyl attachment site [posttranslational modification]; other site 1278073019014 e3 binding domain; Region: E3_binding; pfam02817 1278073019015 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1278073019016 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1278073019017 DNA-binding site [nucleotide binding]; DNA binding site 1278073019018 RNA-binding motif; other site 1278073019019 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 1278073019020 Dienelactone hydrolase family; Region: DLH; pfam01738 1278073019021 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1278073019022 UPF0489 domain; Region: UPF0489; pfam12640 1278073019023 Surface antigen; Region: Bac_surface_Ag; pfam01103 1278073019024 Predicted transcriptional regulators [Transcription]; Region: COG1733 1278073019025 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1278073019026 sulfotransferase; Region: PLN02164 1278073019027 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1278073019028 OsmC-like protein; Region: OsmC; pfam02566 1278073019029 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 1278073019030 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1278073019031 cobalamin binding residues [chemical binding]; other site 1278073019032 putative BtuC binding residues; other site 1278073019033 dimer interface [polypeptide binding]; other site 1278073019034 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073019035 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073019036 active site 1278073019037 ATP binding site [chemical binding]; other site 1278073019038 substrate binding site [chemical binding]; other site 1278073019039 activation loop (A-loop); other site 1278073019040 PEGA domain; Region: PEGA; pfam08308 1278073019041 TPR repeat; Region: TPR_11; pfam13414 1278073019042 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073019043 binding surface 1278073019044 TPR motif; other site 1278073019045 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 1278073019046 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1278073019047 N-terminal plug; other site 1278073019048 ligand-binding site [chemical binding]; other site 1278073019049 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073019050 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073019051 active site 1278073019052 phosphorylation site [posttranslational modification] 1278073019053 intermolecular recognition site; other site 1278073019054 dimerization interface [polypeptide binding]; other site 1278073019055 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 1278073019056 TMAO/DMSO reductase; Reviewed; Region: PRK05363 1278073019057 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1278073019058 Moco binding site; other site 1278073019059 metal coordination site [ion binding]; other site 1278073019060 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1278073019061 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1278073019062 putative di-iron ligands [ion binding]; other site 1278073019063 Nudix hydrolase homolog; Region: PLN02791 1278073019064 Putative phosphatase regulatory subunit; Region: CBM_21; pfam03370 1278073019065 Putative phosphatase regulatory subunit; Region: CBM_21; pfam03370 1278073019066 heat shock protein 90; Provisional; Region: PRK05218 1278073019067 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073019068 ATP binding site [chemical binding]; other site 1278073019069 Mg2+ binding site [ion binding]; other site 1278073019070 G-X-G motif; other site 1278073019071 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1278073019072 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1278073019073 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 1278073019074 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 1278073019075 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1278073019076 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1278073019077 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1278073019078 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1278073019079 active site 1278073019080 ribulose/triose binding site [chemical binding]; other site 1278073019081 phosphate binding site [ion binding]; other site 1278073019082 substrate (anthranilate) binding pocket [chemical binding]; other site 1278073019083 product (indole) binding pocket [chemical binding]; other site 1278073019084 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1278073019085 active site 1278073019086 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1278073019087 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1278073019088 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1278073019089 catalytic residue [active] 1278073019090 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1278073019091 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1278073019092 substrate binding site [chemical binding]; other site 1278073019093 active site 1278073019094 catalytic residues [active] 1278073019095 heterodimer interface [polypeptide binding]; other site 1278073019096 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1278073019097 catalytic core [active] 1278073019098 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1278073019099 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1278073019100 glutamine binding [chemical binding]; other site 1278073019101 catalytic triad [active] 1278073019102 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1278073019103 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1278073019104 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1278073019105 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1278073019106 active site 1278073019107 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 1278073019108 heme-binding residues [chemical binding]; other site 1278073019109 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1278073019110 molybdopterin cofactor binding site; other site 1278073019111 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 1278073019112 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 1278073019113 4Fe-4S binding domain; Region: Fer4_2; pfam12797 1278073019114 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 1278073019115 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 1278073019116 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 1278073019117 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1278073019118 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1278073019119 Cu(I) binding site [ion binding]; other site 1278073019120 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 1278073019121 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1278073019122 Cytochrome c; Region: Cytochrom_C; pfam00034 1278073019123 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1278073019124 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 1278073019125 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 1278073019126 Subunit I/III interface [polypeptide binding]; other site 1278073019127 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626 1278073019128 Protein of unknown function, DUF481; Region: DUF481; pfam04338 1278073019129 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1278073019130 Flagellin N-methylase; Region: FliB; cl00497 1278073019131 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 1278073019132 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1278073019133 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1278073019134 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1278073019135 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1278073019136 ATP binding site [chemical binding]; other site 1278073019137 putative Mg++ binding site [ion binding]; other site 1278073019138 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1278073019139 nucleotide binding region [chemical binding]; other site 1278073019140 ATP-binding site [chemical binding]; other site 1278073019141 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372 1278073019142 Protein of unknown function (DUF790); Region: DUF790; pfam05626 1278073019143 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1278073019144 sequence-specific DNA binding site [nucleotide binding]; other site 1278073019145 salt bridge; other site 1278073019146 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1278073019147 phosphorylation site [posttranslational modification] 1278073019148 intermolecular recognition site; other site 1278073019149 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1278073019150 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1278073019151 active site 1278073019152 metal binding site [ion binding]; metal-binding site 1278073019153 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1278073019154 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1278073019155 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1278073019156 active site 1278073019157 Zn binding site [ion binding]; other site 1278073019158 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1278073019159 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1278073019160 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1278073019161 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1278073019162 NAD(P) binding site [chemical binding]; other site 1278073019163 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1278073019164 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1278073019165 Right handed beta helix region; Region: Beta_helix; pfam13229 1278073019166 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1278073019167 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1278073019168 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1278073019169 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1278073019170 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1278073019171 Ligand binding site; other site 1278073019172 metal-binding site 1278073019173 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 1278073019174 PAS fold; Region: PAS_3; pfam08447 1278073019175 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1278073019176 putative active site [active] 1278073019177 heme pocket [chemical binding]; other site 1278073019178 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073019179 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073019180 dimer interface [polypeptide binding]; other site 1278073019181 phosphorylation site [posttranslational modification] 1278073019182 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073019183 ATP binding site [chemical binding]; other site 1278073019184 Mg2+ binding site [ion binding]; other site 1278073019185 G-X-G motif; other site 1278073019186 TIGR02452 family protein; Region: TIGR02452 1278073019187 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 1278073019188 glutathionine S-transferase; Provisional; Region: PRK10542 1278073019189 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1278073019190 C-terminal domain interface [polypeptide binding]; other site 1278073019191 GSH binding site (G-site) [chemical binding]; other site 1278073019192 dimer interface [polypeptide binding]; other site 1278073019193 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1278073019194 dimer interface [polypeptide binding]; other site 1278073019195 N-terminal domain interface [polypeptide binding]; other site 1278073019196 substrate binding pocket (H-site) [chemical binding]; other site 1278073019197 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1278073019198 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1278073019199 active site 1278073019200 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1278073019201 hypothetical protein; Validated; Region: PRK07883 1278073019202 GIY-YIG motif/motif A; other site 1278073019203 active site 1278073019204 catalytic site [active] 1278073019205 putative DNA binding site [nucleotide binding]; other site 1278073019206 metal binding site [ion binding]; metal-binding site 1278073019207 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1278073019208 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1278073019209 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1278073019210 Coenzyme A binding pocket [chemical binding]; other site 1278073019211 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073019212 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073019213 active site 1278073019214 ATP binding site [chemical binding]; other site 1278073019215 substrate binding site [chemical binding]; other site 1278073019216 activation loop (A-loop); other site 1278073019217 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1278073019218 nucleoside/Zn binding site; other site 1278073019219 dimer interface [polypeptide binding]; other site 1278073019220 catalytic motif [active] 1278073019221 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1278073019222 metal ion-dependent adhesion site (MIDAS); other site 1278073019223 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1278073019224 metal ion-dependent adhesion site (MIDAS); other site 1278073019225 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 1278073019226 metal ion-dependent adhesion site (MIDAS); other site 1278073019227 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1278073019228 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1278073019229 metal-binding site [ion binding] 1278073019230 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1278073019231 Porin subfamily; Region: Porin_2; pfam02530 1278073019232 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1278073019233 substrate binding site [chemical binding]; other site 1278073019234 Domain of unknown function (DUF4041); Region: DUF4041; pfam13250 1278073019235 This entry represents the putative helicase A859L; Region: T5orf172; smart00974 1278073019236 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1278073019237 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1278073019238 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1278073019239 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 1278073019240 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 1278073019241 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 1278073019242 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 1278073019243 putative hydrophobic ligand binding site [chemical binding]; other site 1278073019244 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1278073019245 Coenzyme A binding pocket [chemical binding]; other site 1278073019246 Non-plant Terpene Cyclases, Class 1; Region: Terpene_cyclase_nonplant_C1; cd00687 1278073019247 substrate binding pocket [chemical binding]; other site 1278073019248 substrate-Mg2+ binding site; other site 1278073019249 aspartate-rich region 1; other site 1278073019250 active site lid residues [active] 1278073019251 aspartate-rich region 2; other site 1278073019252 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1278073019253 substrate binding pocket [chemical binding]; other site 1278073019254 substrate-Mg2+ binding site; other site 1278073019255 aspartate-rich region 1; other site 1278073019256 aspartate-rich region 2; other site 1278073019257 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1278073019258 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1278073019259 ligand binding site [chemical binding]; other site 1278073019260 flexible hinge region; other site 1278073019261 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1278073019262 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1278073019263 ligand binding site [chemical binding]; other site 1278073019264 flexible hinge region; other site 1278073019265 HEAT repeats; Region: HEAT_2; pfam13646 1278073019266 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u2; cd11494 1278073019267 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1278073019268 Na binding site [ion binding]; other site 1278073019269 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 1278073019270 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 1278073019271 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 1278073019272 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 1278073019273 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 1278073019274 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 1278073019275 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 1278073019276 Tetratricopeptide repeat; Region: TPR_9; pfam13371 1278073019277 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073019278 Walker A/P-loop; other site 1278073019279 ATP binding site [chemical binding]; other site 1278073019280 AAA domain; Region: AAA_21; pfam13304 1278073019281 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073019282 ABC transporter signature motif; other site 1278073019283 Walker B; other site 1278073019284 D-loop; other site 1278073019285 H-loop/switch region; other site 1278073019286 Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606 1278073019287 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1278073019288 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1278073019289 Cu(I) binding site [ion binding]; other site 1278073019290 YtkA-like; Region: YtkA; pfam13115 1278073019291 GIY-YIG type nucleases (URI domain); Region: GIYc; smart00465 1278073019292 Predicted transcriptional regulators [Transcription]; Region: COG1695 1278073019293 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1278073019294 Protein of unknown function (DUF1048); Region: DUF1048; cl01986 1278073019295 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1278073019296 Beta-lactamase; Region: Beta-lactamase; pfam00144 1278073019297 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1278073019298 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1278073019299 catalytic residues [active] 1278073019300 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1278073019301 alternative sigma factor RpoH; Region: rpoH_proteo; TIGR02392 1278073019302 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073019303 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1278073019304 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1278073019305 DNA binding residues [nucleotide binding] 1278073019306 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1278073019307 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1278073019308 ligand binding site [chemical binding]; other site 1278073019309 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1278073019310 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1278073019311 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1278073019312 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1278073019313 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 1278073019314 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1278073019315 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 1278073019316 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1278073019317 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 1278073019318 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1278073019319 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 1278073019320 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1278073019321 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 1278073019322 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1278073019323 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 1278073019324 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1278073019325 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 1278073019326 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1278073019327 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 1278073019328 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1278073019329 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 1278073019330 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1278073019331 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073019332 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073019333 active site 1278073019334 ATP binding site [chemical binding]; other site 1278073019335 substrate binding site [chemical binding]; other site 1278073019336 activation loop (A-loop); other site 1278073019337 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1278073019338 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073019339 TPR motif; other site 1278073019340 binding surface 1278073019341 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073019342 TPR motif; other site 1278073019343 binding surface 1278073019344 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1278073019345 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073019346 Walker A motif; other site 1278073019347 ATP binding site [chemical binding]; other site 1278073019348 Walker B motif; other site 1278073019349 arginine finger; other site 1278073019350 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1278073019351 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1278073019352 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1278073019353 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1278073019354 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1278073019355 Nitronate monooxygenase; Region: NMO; pfam03060 1278073019356 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1278073019357 FMN binding site [chemical binding]; other site 1278073019358 substrate binding site [chemical binding]; other site 1278073019359 putative catalytic residue [active] 1278073019360 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 1278073019361 Beta-lactamase; Region: Beta-lactamase; pfam00144 1278073019362 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1278073019363 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1278073019364 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 1278073019365 Predicted peptidase [General function prediction only]; Region: COG4099 1278073019366 Right handed beta helix region; Region: Beta_helix; pfam13229 1278073019367 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 1278073019368 O-methyltransferase; Region: Methyltransf_2; pfam00891 1278073019369 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1278073019370 Zn binding site [ion binding]; other site 1278073019371 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1278073019372 Interdomain contacts; other site 1278073019373 Cytokine receptor motif; other site 1278073019374 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1278073019375 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1278073019376 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1278073019377 Surface antigen; Region: Bac_surface_Ag; pfam01103 1278073019378 tRNA synthetases class I (I, L, M and V); Region: tRNA-synt_1; pfam00133 1278073019379 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1278073019380 active site 1278073019381 HIGH motif; other site 1278073019382 nucleotide binding site [chemical binding]; other site 1278073019383 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1278073019384 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1278073019385 active site 1278073019386 KMSKS motif; other site 1278073019387 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1278073019388 tRNA binding surface [nucleotide binding]; other site 1278073019389 anticodon binding site; other site 1278073019390 Anticodon-binding domain of tRNA; Region: Anticodon_1; pfam08264 1278073019391 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1278073019392 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 1278073019393 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1278073019394 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1278073019395 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 1278073019396 Domain of unknown function (DUF4040); Region: DUF4040; pfam13244 1278073019397 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1278073019398 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1278073019399 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 1278073019400 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 1278073019401 Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899 1278073019402 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1278073019403 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1278073019404 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073019405 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1278073019406 NAD(P) binding site [chemical binding]; other site 1278073019407 active site 1278073019408 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1278073019409 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1278073019410 short chain dehydrogenase; Provisional; Region: PRK06197 1278073019411 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1278073019412 putative NAD(P) binding site [chemical binding]; other site 1278073019413 active site 1278073019414 NHL repeat; Region: NHL; pfam01436 1278073019415 NHL repeat; Region: NHL; pfam01436 1278073019416 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 1278073019417 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1278073019418 Condensation domain; Region: Condensation; pfam00668 1278073019419 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1278073019420 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1278073019421 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 1278073019422 active site clefts [active] 1278073019423 zinc binding site [ion binding]; other site 1278073019424 dimer interface [polypeptide binding]; other site 1278073019425 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1278073019426 SWIM zinc finger; Region: SWIM; pfam04434 1278073019427 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1278073019428 putative active site [active] 1278073019429 transaldolase; Provisional; Region: PRK03903 1278073019430 catalytic residue [active] 1278073019431 transketolase; Reviewed; Region: PRK05899 1278073019432 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1278073019433 TPP-binding site [chemical binding]; other site 1278073019434 dimer interface [polypeptide binding]; other site 1278073019435 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1278073019436 PYR/PP interface [polypeptide binding]; other site 1278073019437 dimer interface [polypeptide binding]; other site 1278073019438 TPP binding site [chemical binding]; other site 1278073019439 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1278073019440 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1278073019441 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 1278073019442 structural tetrad; other site 1278073019443 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1278073019444 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1278073019445 structural tetrad; other site 1278073019446 Uncharacterized conserved protein (DUF2181); Region: DUF2181; pfam10223 1278073019447 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1278073019448 sugar binding site [chemical binding]; other site 1278073019449 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1278073019450 Predicted peptidase [General function prediction only]; Region: COG4099 1278073019451 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1278073019452 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 1278073019453 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1278073019454 dimerization interface [polypeptide binding]; other site 1278073019455 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1278073019456 cyclase homology domain; Region: CHD; cd07302 1278073019457 nucleotidyl binding site; other site 1278073019458 metal binding site [ion binding]; metal-binding site 1278073019459 dimer interface [polypeptide binding]; other site 1278073019460 glutathionine S-transferase; Provisional; Region: PRK10542 1278073019461 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1278073019462 C-terminal domain interface [polypeptide binding]; other site 1278073019463 GSH binding site (G-site) [chemical binding]; other site 1278073019464 dimer interface [polypeptide binding]; other site 1278073019465 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1278073019466 dimer interface [polypeptide binding]; other site 1278073019467 N-terminal domain interface [polypeptide binding]; other site 1278073019468 substrate binding pocket (H-site) [chemical binding]; other site 1278073019469 Predicted transcriptional regulators [Transcription]; Region: COG1733 1278073019470 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1278073019471 Uncharacterized conserved protein [Function unknown]; Region: COG5276 1278073019472 LVIVD repeat; Region: LVIVD; pfam08309 1278073019473 Uncharacterized conserved protein [Function unknown]; Region: COG5276 1278073019474 LVIVD repeat; Region: LVIVD; pfam08309 1278073019475 Uncharacterized conserved protein [Function unknown]; Region: COG5276 1278073019476 LVIVD repeat; Region: LVIVD; pfam08309 1278073019477 LVIVD repeat; Region: LVIVD; pfam08309 1278073019478 choice-of-anchor B domain; Region: choice_anch_B; TIGR04312 1278073019479 LVIVD repeat; Region: LVIVD; pfam08309 1278073019480 LVIVD repeat; Region: LVIVD; pfam08309 1278073019481 Uncharacterized conserved protein [Function unknown]; Region: COG5276 1278073019482 LVIVD repeat; Region: LVIVD; pfam08309 1278073019483 LVIVD repeat; Region: LVIVD; pfam08309 1278073019484 Uncharacterized conserved protein [Function unknown]; Region: COG5276 1278073019485 LVIVD repeat; Region: LVIVD; pfam08309 1278073019486 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 1278073019487 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1278073019488 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1278073019489 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 1278073019490 Restriction endonuclease EcoRV; Region: Endonuc-EcoRV; pfam09233 1278073019491 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 1278073019492 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 1278073019493 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1278073019494 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1278073019495 DNA binding residues [nucleotide binding] 1278073019496 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 1278073019497 YCII-related domain; Region: YCII; cl00999 1278073019498 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1278073019499 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1278073019500 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1278073019501 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1278073019502 NAD(P) binding site [chemical binding]; other site 1278073019503 substrate binding site [chemical binding]; other site 1278073019504 dimer interface [polypeptide binding]; other site 1278073019505 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1278073019506 Phosphoesterase family; Region: Phosphoesterase; pfam04185 1278073019507 Scramblase; Region: Scramblase; pfam03803 1278073019508 Beta-lactamase; Region: Beta-lactamase; pfam00144 1278073019509 D-aminopeptidase; Reviewed; Region: PRK13128 1278073019510 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 1278073019511 LysR family transcriptional regulator; Provisional; Region: PRK14997 1278073019512 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1278073019513 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1278073019514 putative effector binding pocket; other site 1278073019515 dimerization interface [polypeptide binding]; other site 1278073019516 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1278073019517 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1278073019518 FMN binding site [chemical binding]; other site 1278073019519 active site 1278073019520 substrate binding site [chemical binding]; other site 1278073019521 catalytic residue [active] 1278073019522 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1278073019523 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 1278073019524 putative hydrophobic ligand binding site [chemical binding]; other site 1278073019525 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1278073019526 dimerization interface [polypeptide binding]; other site 1278073019527 putative DNA binding site [nucleotide binding]; other site 1278073019528 putative Zn2+ binding site [ion binding]; other site 1278073019529 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 1278073019530 serpin-like protein; Provisional; Region: PHA02660 1278073019531 reactive center loop; other site 1278073019532 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1278073019533 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1278073019534 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1278073019535 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1278073019536 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1278073019537 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1278073019538 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1278073019539 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1278073019540 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1278073019541 conserved hypothetical protein; Region: TIGR02270 1278073019542 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 1278073019543 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 1278073019544 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1278073019545 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 1278073019546 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1278073019547 Isochorismatase family; Region: Isochorismatase; pfam00857 1278073019548 catalytic triad [active] 1278073019549 conserved cis-peptide bond; other site 1278073019550 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 1278073019551 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 1278073019552 conserved cys residue [active] 1278073019553 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1278073019554 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1278073019555 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 1278073019556 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 1278073019557 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 1278073019558 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 1278073019559 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 1278073019560 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1278073019561 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073019562 Walker A motif; other site 1278073019563 ATP binding site [chemical binding]; other site 1278073019564 Walker B motif; other site 1278073019565 arginine finger; other site 1278073019566 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 1278073019567 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 1278073019568 The Death Domain Superfamily of protein-protein interaction domains; Region: DD_superfamily; cl14633 1278073019569 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1278073019570 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1278073019571 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1278073019572 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1278073019573 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1278073019574 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1278073019575 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1278073019576 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1278073019577 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1278073019578 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1278073019579 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 1278073019580 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 1278073019581 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 1278073019582 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 1278073019583 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 1278073019584 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 1278073019585 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 1278073019586 phage tail protein domain; Region: tail_TIGR02242 1278073019587 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 1278073019588 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 1278073019589 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 1278073019590 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 1278073019591 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1278073019592 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1278073019593 structural tetrad; other site 1278073019594 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073019595 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073019596 active site 1278073019597 phosphorylation site [posttranslational modification] 1278073019598 intermolecular recognition site; other site 1278073019599 dimerization interface [polypeptide binding]; other site 1278073019600 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1278073019601 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1278073019602 substrate binding site [chemical binding]; other site 1278073019603 hexamer interface [polypeptide binding]; other site 1278073019604 metal binding site [ion binding]; metal-binding site 1278073019605 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1278073019606 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 1278073019607 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1278073019608 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 1278073019609 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1278073019610 active site 1278073019611 domain interfaces; other site 1278073019612 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 1278073019613 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1278073019614 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1278073019615 beta-galactosidase; Region: BGL; TIGR03356 1278073019616 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1278073019617 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1278073019618 FMN binding site [chemical binding]; other site 1278073019619 active site 1278073019620 catalytic residues [active] 1278073019621 substrate binding site [chemical binding]; other site 1278073019622 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 1278073019623 Peptidase family M50; Region: Peptidase_M50; pfam02163 1278073019624 active site 1278073019625 putative substrate binding region [chemical binding]; other site 1278073019626 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1278073019627 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1278073019628 Di-iron ligands [ion binding]; other site 1278073019629 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1278073019630 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073019631 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1278073019632 DNA binding residues [nucleotide binding] 1278073019633 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1278073019634 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1278073019635 Cl- selectivity filter; other site 1278073019636 Cl- binding residues [ion binding]; other site 1278073019637 pore gating glutamate residue; other site 1278073019638 dimer interface [polypeptide binding]; other site 1278073019639 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1278073019640 Predicted acetyltransferase [General function prediction only]; Region: COG5628 1278073019641 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1278073019642 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1278073019643 catalytic triad [active] 1278073019644 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1278073019645 putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203 1278073019646 active site 1278073019647 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073019648 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073019649 active site 1278073019650 ATP binding site [chemical binding]; other site 1278073019651 substrate binding site [chemical binding]; other site 1278073019652 activation loop (A-loop); other site 1278073019653 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073019654 binding surface 1278073019655 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1278073019656 TPR motif; other site 1278073019657 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073019658 binding surface 1278073019659 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1278073019660 TPR motif; other site 1278073019661 YdjC-like protein; Region: YdjC; pfam04794 1278073019662 GAF domain; Region: GAF_3; pfam13492 1278073019663 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073019664 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1278073019665 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073019666 ATP binding site [chemical binding]; other site 1278073019667 Mg2+ binding site [ion binding]; other site 1278073019668 G-X-G motif; other site 1278073019669 7-cyano-7-deazaguanine reductase; Region: QueF-II; TIGR03139 1278073019670 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1278073019671 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073019672 active site 1278073019673 ATP binding site [chemical binding]; other site 1278073019674 substrate binding site [chemical binding]; other site 1278073019675 activation loop (A-loop); other site 1278073019676 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1278073019677 PLD-like domain; Region: PLDc_2; pfam13091 1278073019678 putative active site [active] 1278073019679 catalytic site [active] 1278073019680 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 1278073019681 PLD-like domain; Region: PLDc_2; pfam13091 1278073019682 putative active site [active] 1278073019683 catalytic site [active] 1278073019684 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 1278073019685 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1278073019686 HD domain; Region: HD; pfam01966 1278073019687 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1278073019688 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1278073019689 NAD binding site [chemical binding]; other site 1278073019690 catalytic Zn binding site [ion binding]; other site 1278073019691 structural Zn binding site [ion binding]; other site 1278073019692 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 1278073019693 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1278073019694 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1278073019695 classical (c) SDRs; Region: SDR_c; cd05233 1278073019696 NAD(P) binding site [chemical binding]; other site 1278073019697 active site 1278073019698 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1278073019699 non-specific DNA binding site [nucleotide binding]; other site 1278073019700 salt bridge; other site 1278073019701 sequence-specific DNA binding site [nucleotide binding]; other site 1278073019702 Cupin domain; Region: Cupin_2; pfam07883 1278073019703 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 1278073019704 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 1278073019705 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1278073019706 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 1278073019707 Right handed beta helix region; Region: Beta_helix; pfam13229 1278073019708 Right handed beta helix region; Region: Beta_helix; pfam13229 1278073019709 Cys-rich repeat, Myxococcales-type; Region: Myxo_Cys_RPT; TIGR04201 1278073019710 Right handed beta helix region; Region: Beta_helix; pfam13229 1278073019711 Right handed beta helix region; Region: Beta_helix; pfam13229 1278073019712 Cys-rich repeat, Myxococcales-type; Region: Myxo_Cys_RPT; TIGR04201 1278073019713 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1278073019714 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 1278073019715 putative effector binding pocket; other site 1278073019716 putative dimerization interface [polypeptide binding]; other site 1278073019717 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 1278073019718 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1278073019719 putative NAD(P) binding site [chemical binding]; other site 1278073019720 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1278073019721 conserved cys residue [active] 1278073019722 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1278073019723 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1278073019724 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1278073019725 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1278073019726 PAS domain; Region: PAS_9; pfam13426 1278073019727 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073019728 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073019729 ATP binding site [chemical binding]; other site 1278073019730 Mg2+ binding site [ion binding]; other site 1278073019731 G-X-G motif; other site 1278073019732 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073019733 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073019734 active site 1278073019735 phosphorylation site [posttranslational modification] 1278073019736 intermolecular recognition site; other site 1278073019737 dimerization interface [polypeptide binding]; other site 1278073019738 Predicted integral membrane protein (DUF2270); Region: DUF2270; pfam10028 1278073019739 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1278073019740 tartrate dehydrogenase; Region: TTC; TIGR02089 1278073019741 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 1278073019742 putative rRNA binding site [nucleotide binding]; other site 1278073019743 Vitamin K epoxide reductase family in bacteria; Region: VKOR_3; cd12920 1278073019744 putative active site [active] 1278073019745 redox center [active] 1278073019746 Thioredoxin; Region: Thioredoxin_4; cl17273 1278073019747 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1278073019748 Cupin domain; Region: Cupin_2; cl17218 1278073019749 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 1278073019750 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1278073019751 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1278073019752 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 1278073019753 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1278073019754 Chromate transporter; Region: Chromate_transp; pfam02417 1278073019755 OsmC-like protein; Region: OsmC; pfam02566 1278073019756 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 1278073019757 maleylacetoacetate isomerase; Region: maiA; TIGR01262 1278073019758 C-terminal domain interface [polypeptide binding]; other site 1278073019759 GSH binding site (G-site) [chemical binding]; other site 1278073019760 putative dimer interface [polypeptide binding]; other site 1278073019761 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 1278073019762 dimer interface [polypeptide binding]; other site 1278073019763 N-terminal domain interface [polypeptide binding]; other site 1278073019764 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 1278073019765 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1278073019766 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1278073019767 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073019768 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073019769 active site 1278073019770 ATP binding site [chemical binding]; other site 1278073019771 substrate binding site [chemical binding]; other site 1278073019772 activation loop (A-loop); other site 1278073019773 AAA ATPase domain; Region: AAA_16; pfam13191 1278073019774 Predicted ATPase [General function prediction only]; Region: COG3899 1278073019775 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073019776 binding surface 1278073019777 TPR motif; other site 1278073019778 GAF domain; Region: GAF; pfam01590 1278073019779 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073019780 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073019781 dimer interface [polypeptide binding]; other site 1278073019782 phosphorylation site [posttranslational modification] 1278073019783 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073019784 ATP binding site [chemical binding]; other site 1278073019785 Mg2+ binding site [ion binding]; other site 1278073019786 G-X-G motif; other site 1278073019787 Protein kinase domain; Region: Pkinase; pfam00069 1278073019788 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073019789 active site 1278073019790 ATP binding site [chemical binding]; other site 1278073019791 substrate binding site [chemical binding]; other site 1278073019792 activation loop (A-loop); other site 1278073019793 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1278073019794 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1278073019795 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1278073019796 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1278073019797 ligand binding site [chemical binding]; other site 1278073019798 NAD binding site [chemical binding]; other site 1278073019799 tetramer interface [polypeptide binding]; other site 1278073019800 catalytic site [active] 1278073019801 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1278073019802 L-serine binding site [chemical binding]; other site 1278073019803 ACT domain interface; other site 1278073019804 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1278073019805 FAD binding domain; Region: FAD_binding_4; pfam01565 1278073019806 RibD C-terminal domain; Region: RibD_C; cl17279 1278073019807 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1278073019808 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 1278073019809 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 1278073019810 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073019811 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1278073019812 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1278073019813 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1278073019814 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1278073019815 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1278073019816 catalytic residue [active] 1278073019817 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1278073019818 Beta-lactamase; Region: Beta-lactamase; pfam00144 1278073019819 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1278073019820 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073019821 active site 1278073019822 phosphorylation site [posttranslational modification] 1278073019823 intermolecular recognition site; other site 1278073019824 dimerization interface [polypeptide binding]; other site 1278073019825 LytTr DNA-binding domain; Region: LytTR; smart00850 1278073019826 Histidine kinase; Region: His_kinase; pfam06580 1278073019827 HEAT repeats; Region: HEAT_2; pfam13646 1278073019828 von Willebrand factor; Region: vWF_A; pfam12450 1278073019829 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1278073019830 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 1278073019831 metal ion-dependent adhesion site (MIDAS); other site 1278073019832 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 1278073019833 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1278073019834 Amidase; Region: Amidase; cl11426 1278073019835 6-phosphofructokinase; Provisional; Region: PRK03202 1278073019836 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1278073019837 active site 1278073019838 ADP/pyrophosphate binding site [chemical binding]; other site 1278073019839 dimerization interface [polypeptide binding]; other site 1278073019840 allosteric effector site; other site 1278073019841 fructose-1,6-bisphosphate binding site; other site 1278073019842 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 1278073019843 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 1278073019844 dimer interface [polypeptide binding]; other site 1278073019845 acyl-activating enzyme (AAE) consensus motif; other site 1278073019846 putative active site [active] 1278073019847 AMP binding site [chemical binding]; other site 1278073019848 putative CoA binding site [chemical binding]; other site 1278073019849 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1278073019850 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1278073019851 phosphopeptide binding site; other site 1278073019852 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1278073019853 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1278073019854 putative active site [active] 1278073019855 putative metal binding site [ion binding]; other site 1278073019856 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1278073019857 intersubunit interface [polypeptide binding]; other site 1278073019858 active site 1278073019859 Zn2+ binding site [ion binding]; other site 1278073019860 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1278073019861 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 1278073019862 5'-methylthioadenosine phosphorylase; Provisional; Region: PRK08931 1278073019863 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1278073019864 dimerization interface [polypeptide binding]; other site 1278073019865 putative DNA binding site [nucleotide binding]; other site 1278073019866 putative Zn2+ binding site [ion binding]; other site 1278073019867 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 1278073019868 putative hydrophobic ligand binding site [chemical binding]; other site 1278073019869 FOG: CBS domain [General function prediction only]; Region: COG0517 1278073019870 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1278073019871 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1278073019872 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1278073019873 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073019874 active site 1278073019875 phosphorylation site [posttranslational modification] 1278073019876 intermolecular recognition site; other site 1278073019877 dimerization interface [polypeptide binding]; other site 1278073019878 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1278073019879 DNA binding site [nucleotide binding] 1278073019880 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073019881 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073019882 dimer interface [polypeptide binding]; other site 1278073019883 phosphorylation site [posttranslational modification] 1278073019884 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073019885 ATP binding site [chemical binding]; other site 1278073019886 G-X-G motif; other site 1278073019887 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073019888 von Willebrand factor; Region: vWF_A; pfam12450 1278073019889 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 1278073019890 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 1278073019891 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1278073019892 Ligand Binding Site [chemical binding]; other site 1278073019893 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073019894 binding surface 1278073019895 TPR motif; other site 1278073019896 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073019897 TPR motif; other site 1278073019898 binding surface 1278073019899 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073019900 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073019901 active site 1278073019902 ATP binding site [chemical binding]; other site 1278073019903 substrate binding site [chemical binding]; other site 1278073019904 activation loop (A-loop); other site 1278073019905 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1278073019906 cyclase homology domain; Region: CHD; cd07302 1278073019907 nucleotidyl binding site; other site 1278073019908 metal binding site [ion binding]; metal-binding site 1278073019909 dimer interface [polypeptide binding]; other site 1278073019910 HEAT repeats; Region: HEAT_2; pfam13646 1278073019911 NlpC/P60 family; Region: NLPC_P60; cl17555 1278073019912 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1278073019913 Coenzyme A binding pocket [chemical binding]; other site 1278073019914 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1278073019915 endonuclease III; Region: ENDO3c; smart00478 1278073019916 minor groove reading motif; other site 1278073019917 helix-hairpin-helix signature motif; other site 1278073019918 substrate binding pocket [chemical binding]; other site 1278073019919 active site 1278073019920 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1278073019921 acyl-coenzyme A oxidase; Region: PLN02636 1278073019922 active site 1278073019923 Protein of unknown function (DUF3293); Region: DUF3293; pfam11697 1278073019924 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 1278073019925 NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530 1278073019926 putative active site [active] 1278073019927 putative metal binding site [ion binding]; other site 1278073019928 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1278073019929 Clp protease; Region: CLP_protease; pfam00574 1278073019930 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1278073019931 oligomer interface [polypeptide binding]; other site 1278073019932 active site residues [active] 1278073019933 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1278073019934 Class II fumarases; Region: Fumarase_classII; cd01362 1278073019935 active site 1278073019936 tetramer interface [polypeptide binding]; other site 1278073019937 PspC domain; Region: PspC; pfam04024 1278073019938 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 1278073019939 malate synthase A; Region: malate_syn_A; TIGR01344 1278073019940 active site 1278073019941 isocitrate lyase; Provisional; Region: PRK15063 1278073019942 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1278073019943 tetramer interface [polypeptide binding]; other site 1278073019944 active site 1278073019945 Mg2+/Mn2+ binding site [ion binding]; other site 1278073019946 Low affinity iron permease; Region: Iron_permease; cl12096 1278073019947 B12-binding domain/radical SAM domain protein, MJ_1487 family; Region: B12_SAM_MJ_1487; TIGR04013 1278073019948 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 1278073019949 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1278073019950 FeS/SAM binding site; other site 1278073019951 tyrosine decarboxylase; Region: PLN02880 1278073019952 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1278073019953 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1278073019954 catalytic residue [active] 1278073019955 GAF domain; Region: GAF; pfam01590 1278073019956 GAF domain; Region: GAF_2; pfam13185 1278073019957 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073019958 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1278073019959 Walker A motif; other site 1278073019960 ATP binding site [chemical binding]; other site 1278073019961 Walker B motif; other site 1278073019962 arginine finger; other site 1278073019963 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 1278073019964 SnoaL-like domain; Region: SnoaL_2; pfam12680 1278073019965 Family description; Region: VCBS; pfam13517 1278073019966 Family description; Region: VCBS; pfam13517 1278073019967 Family description; Region: VCBS; pfam13517 1278073019968 Family description; Region: VCBS; pfam13517 1278073019969 Family description; Region: VCBS; pfam13517 1278073019970 Family description; Region: VCBS; pfam13517 1278073019971 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 1278073019972 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 1278073019973 SnoaL-like domain; Region: SnoaL_2; pfam12680 1278073019974 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1278073019975 MarR family; Region: MarR_2; pfam12802 1278073019976 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1278073019977 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1278073019978 catalytic residues [active] 1278073019979 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1278073019980 HlyD family secretion protein; Region: HlyD_3; pfam13437 1278073019981 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1278073019982 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073019983 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073019984 active site 1278073019985 ATP binding site [chemical binding]; other site 1278073019986 substrate binding site [chemical binding]; other site 1278073019987 activation loop (A-loop); other site 1278073019988 PEGA domain; Region: PEGA; pfam08308 1278073019989 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1278073019990 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 1278073019991 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1278073019992 Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958 1278073019993 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1278073019994 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1278073019995 dimer interface [polypeptide binding]; other site 1278073019996 putative CheW interface [polypeptide binding]; other site 1278073019997 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1278073019998 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1278073019999 Dictyostelium (slime mold) repeat; Region: Dicty_CTDC; pfam00526 1278073020000 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1278073020001 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1278073020002 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cl00364 1278073020003 L11 interface [polypeptide binding]; other site 1278073020004 putative EF-Tu interaction site [polypeptide binding]; other site 1278073020005 putative EF-G interaction site [polypeptide binding]; other site 1278073020006 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14470 1278073020007 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1278073020008 FeS/SAM binding site; other site 1278073020009 Putative zinc-finger; Region: zf-HC2; pfam13490 1278073020010 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1278073020011 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073020012 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1278073020013 DNA binding residues [nucleotide binding] 1278073020014 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1278073020015 active site 1278073020016 DNA binding site [nucleotide binding] 1278073020017 4-alpha-glucanotransferase; Provisional; Region: PRK14508 1278073020018 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1278073020019 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1278073020020 Surface antigen; Region: Bac_surface_Ag; pfam01103 1278073020021 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1278073020022 Family of unknown function (DUF490); Region: DUF490; pfam04357 1278073020023 Protein of unknown function (Gmx_para_CXXCG); Region: Gmx_para_CXXCG; cl15282 1278073020024 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1278073020025 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 1278073020026 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1278073020027 metal ion-dependent adhesion site (MIDAS); other site 1278073020028 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 1278073020029 Protein of unknown function DUF58; Region: DUF58; pfam01882 1278073020030 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1278073020031 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1278073020032 Walker A/P-loop; other site 1278073020033 ATP binding site [chemical binding]; other site 1278073020034 Q-loop/lid; other site 1278073020035 ABC transporter signature motif; other site 1278073020036 Walker B; other site 1278073020037 D-loop; other site 1278073020038 H-loop/switch region; other site 1278073020039 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1278073020040 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073020041 Walker A motif; other site 1278073020042 ATP binding site [chemical binding]; other site 1278073020043 Walker B motif; other site 1278073020044 arginine finger; other site 1278073020045 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1278073020046 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 1278073020047 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 1278073020048 catalytic site [active] 1278073020049 active site 1278073020050 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1278073020051 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1278073020052 Predicted membrane protein [Function unknown]; Region: COG4270 1278073020053 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1278073020054 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1278073020055 active site 1278073020056 catalytic tetrad [active] 1278073020057 NLI interacting factor-like phosphatase; Region: NIF; pfam03031 1278073020058 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1278073020059 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1278073020060 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1278073020061 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1278073020062 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1278073020063 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 1278073020064 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1278073020065 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1278073020066 MarR family; Region: MarR; pfam01047 1278073020067 Outer membrane efflux protein; Region: OEP; pfam02321 1278073020068 Outer membrane efflux protein; Region: OEP; pfam02321 1278073020069 Phospholipid methyltransferase; Region: PEMT; cl17370 1278073020070 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1278073020071 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1278073020072 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1278073020073 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1278073020074 iron-sulfur cluster [ion binding]; other site 1278073020075 [2Fe-2S] cluster binding site [ion binding]; other site 1278073020076 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1278073020077 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1278073020078 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1278073020079 motif II; other site 1278073020080 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1278073020081 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1278073020082 Domain of unknown function (DUF3943); Region: DUF3943; pfam13084 1278073020083 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073020084 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1278073020085 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1278073020086 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1278073020087 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1278073020088 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1278073020089 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1278073020090 Protein of unknown function, DUF547; Region: DUF547; pfam04784 1278073020091 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1278073020092 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1278073020093 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1278073020094 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1278073020095 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1278073020096 motif II; other site 1278073020097 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1278073020098 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1278073020099 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1278073020100 non-specific DNA binding site [nucleotide binding]; other site 1278073020101 salt bridge; other site 1278073020102 sequence-specific DNA binding site [nucleotide binding]; other site 1278073020103 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1278073020104 dimer interface [polypeptide binding]; other site 1278073020105 catalytic triad [active] 1278073020106 peroxidatic and resolving cysteines [active] 1278073020107 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1278073020108 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1278073020109 nucleotide binding site [chemical binding]; other site 1278073020110 Predicted flavoprotein [General function prediction only]; Region: COG0431 1278073020111 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1278073020112 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1278073020113 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1278073020114 active site 1278073020115 substrate binding site [chemical binding]; other site 1278073020116 metal binding site [ion binding]; metal-binding site 1278073020117 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1278073020118 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073020119 active site 1278073020120 ATP binding site [chemical binding]; other site 1278073020121 substrate binding site [chemical binding]; other site 1278073020122 activation loop (A-loop); other site 1278073020123 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 1278073020124 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1278073020125 Substrate binding site; other site 1278073020126 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1278073020127 oxyanion hole [active] 1278073020128 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1278073020129 active site 1278073020130 oxyanion hole [active] 1278073020131 catalytic triad [active] 1278073020132 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1278073020133 SGNH_peri1; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri1; cd01825 1278073020134 active site 1278073020135 oxyanion hole [active] 1278073020136 catalytic triad [active] 1278073020137 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 1278073020138 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1278073020139 putative active site [active] 1278073020140 putative CoA binding site [chemical binding]; other site 1278073020141 nudix motif; other site 1278073020142 metal binding site [ion binding]; metal-binding site 1278073020143 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 1278073020144 hypothetical protein; Provisional; Region: PRK04233 1278073020145 SEC-C motif; Region: SEC-C; pfam02810 1278073020146 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 1278073020147 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1278073020148 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1278073020149 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1278073020150 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1278073020151 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 1278073020152 Site-specific recombinase; Region: SpecificRecomb; pfam10136 1278073020153 Domain of unknown function (DUF368); Region: DUF368; cl00893 1278073020154 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1278073020155 MgtC family; Region: MgtC; pfam02308 1278073020156 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1278073020157 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1278073020158 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1278073020159 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1278073020160 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1278073020161 dimerization domain swap beta strand [polypeptide binding]; other site 1278073020162 regulatory protein interface [polypeptide binding]; other site 1278073020163 active site 1278073020164 regulatory phosphorylation site [posttranslational modification]; other site 1278073020165 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 1278073020166 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 1278073020167 active site 1278073020168 phosphorylation site [posttranslational modification] 1278073020169 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1278073020170 active pocket/dimerization site; other site 1278073020171 active site 1278073020172 phosphorylation site [posttranslational modification] 1278073020173 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1278073020174 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1278073020175 catalytic triad [active] 1278073020176 Peptidase M35 domain of peptidyl-Lys metalloendopeptidases; Region: M35_peptidyl-Lys; cd11306 1278073020177 active site 1278073020178 Zn binding site [ion binding]; other site 1278073020179 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1278073020180 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1278073020181 putative active site [active] 1278073020182 putative metal binding site [ion binding]; other site 1278073020183 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073020184 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073020185 active site 1278073020186 ATP binding site [chemical binding]; other site 1278073020187 substrate binding site [chemical binding]; other site 1278073020188 activation loop (A-loop); other site 1278073020189 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 1278073020190 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1278073020191 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 1278073020192 active site 1278073020193 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073020194 short chain dehydrogenase; Provisional; Region: PRK05650 1278073020195 NAD(P) binding site [chemical binding]; other site 1278073020196 active site 1278073020197 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 1278073020198 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1278073020199 Predicted membrane protein [Function unknown]; Region: COG1971 1278073020200 Domain of unknown function DUF; Region: DUF204; pfam02659 1278073020201 Domain of unknown function DUF; Region: DUF204; pfam02659 1278073020202 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1278073020203 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1278073020204 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1278073020205 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1278073020206 Hpr binding site; other site 1278073020207 active site 1278073020208 homohexamer subunit interaction site [polypeptide binding]; other site 1278073020209 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1278073020210 nucleotide binding site/active site [active] 1278073020211 HIT family signature motif; other site 1278073020212 catalytic residue [active] 1278073020213 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1278073020214 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1278073020215 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1278073020216 Carbon starvation protein CstA; Region: CstA; pfam02554 1278073020217 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1278073020218 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073020219 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073020220 active site 1278073020221 ATP binding site [chemical binding]; other site 1278073020222 substrate binding site [chemical binding]; other site 1278073020223 activation loop (A-loop); other site 1278073020224 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1278073020225 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1278073020226 phosphopeptide binding site; other site 1278073020227 GAF domain; Region: GAF; cl17456 1278073020228 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1278073020229 cyclase homology domain; Region: CHD; cd07302 1278073020230 nucleotidyl binding site; other site 1278073020231 metal binding site [ion binding]; metal-binding site 1278073020232 dimer interface [polypeptide binding]; other site 1278073020233 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1278073020234 iron-sulfur cluster [ion binding]; other site 1278073020235 [2Fe-2S] cluster binding site [ion binding]; other site 1278073020236 Herpesvirus latent membrane protein 1 (LMP1); Region: Herpes_LMP1; pfam05297 1278073020237 Stigma-specific protein, Stig1; Region: Stig1; pfam04885 1278073020238 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 1278073020239 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1278073020240 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1278073020241 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1278073020242 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1278073020243 phosphopeptide binding site; other site 1278073020244 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1278073020245 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073020246 binding surface 1278073020247 TPR motif; other site 1278073020248 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1278073020249 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073020250 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1278073020251 DNA binding residues [nucleotide binding] 1278073020252 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 1278073020253 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1278073020254 active site 1278073020255 dimer interface [polypeptide binding]; other site 1278073020256 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1278073020257 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1278073020258 Peptidase family C69; Region: Peptidase_C69; cl17793 1278073020259 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1278073020260 MarR family; Region: MarR_2; pfam12802 1278073020261 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 1278073020262 linker region; other site 1278073020263 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1278073020264 Zn binding site [ion binding]; other site 1278073020265 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073020266 binding surface 1278073020267 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1278073020268 TPR motif; other site 1278073020269 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 1278073020270 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1278073020271 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1278073020272 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1278073020273 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1278073020274 catalytic residues [active] 1278073020275 Myxococcus xanthus paralogous domain TIGR02266; Region: gmx_TIGR02266 1278073020276 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1278073020277 nucleotide binding site [chemical binding]; other site 1278073020278 MoxR-like ATPases [General function prediction only]; Region: COG0714 1278073020279 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073020280 Walker A motif; other site 1278073020281 ATP binding site [chemical binding]; other site 1278073020282 Walker B motif; other site 1278073020283 arginine finger; other site 1278073020284 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1278073020285 Protein of unknown function DUF58; Region: DUF58; pfam01882 1278073020286 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1278073020287 metal ion-dependent adhesion site (MIDAS); other site 1278073020288 N-terminal double-transmembrane domain; Region: two_anch; TIGR02226 1278073020289 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1278073020290 CARDB; Region: CARDB; pfam07705 1278073020291 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1278073020292 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1278073020293 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1278073020294 DNA binding residues [nucleotide binding] 1278073020295 dimerization interface [polypeptide binding]; other site 1278073020296 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 1278073020297 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1278073020298 ATP binding site [chemical binding]; other site 1278073020299 Mg++ binding site [ion binding]; other site 1278073020300 motif III; other site 1278073020301 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1278073020302 nucleotide binding region [chemical binding]; other site 1278073020303 ATP-binding site [chemical binding]; other site 1278073020304 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 1278073020305 putative RNA binding site [nucleotide binding]; other site 1278073020306 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1278073020307 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1278073020308 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1278073020309 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1278073020310 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1278073020311 catalytic triad [active] 1278073020312 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 1278073020313 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073020314 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073020315 active site 1278073020316 phosphorylation site [posttranslational modification] 1278073020317 intermolecular recognition site; other site 1278073020318 dimerization interface [polypeptide binding]; other site 1278073020319 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 1278073020320 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 1278073020321 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073020322 S-adenosylmethionine binding site [chemical binding]; other site 1278073020323 hypothetical protein; Validated; Region: PRK08238 1278073020324 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 1278073020325 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1278073020326 FAD binding domain; Region: FAD_binding_4; pfam01565 1278073020327 short chain dehydrogenase; Provisional; Region: PRK07102 1278073020328 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1278073020329 NAD(P) binding site [chemical binding]; other site 1278073020330 active site 1278073020331 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1278073020332 putative active site [active] 1278073020333 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1278073020334 putative active site [active] 1278073020335 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1278073020336 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1278073020337 active site 1278073020338 catalytic tetrad [active] 1278073020339 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1278073020340 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1278073020341 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1278073020342 putative effector binding pocket; other site 1278073020343 putative dimerization interface [polypeptide binding]; other site 1278073020344 RecX family; Region: RecX; pfam02631 1278073020345 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1278073020346 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1278073020347 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1278073020348 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1278073020349 acyl-CoA synthetase; Validated; Region: PRK09192 1278073020350 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1278073020351 acyl-activating enzyme (AAE) consensus motif; other site 1278073020352 active site 1278073020353 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1278073020354 Phospholipid methyltransferase; Region: PEMT; cl17370 1278073020355 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1278073020356 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1278073020357 malonyl-CoA binding site [chemical binding]; other site 1278073020358 dimer interface [polypeptide binding]; other site 1278073020359 active site 1278073020360 product binding site; other site 1278073020361 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1278073020362 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105 1278073020363 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1278073020364 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1278073020365 FAD binding pocket [chemical binding]; other site 1278073020366 FAD binding motif [chemical binding]; other site 1278073020367 phosphate binding motif [ion binding]; other site 1278073020368 NAD binding pocket [chemical binding]; other site 1278073020369 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1278073020370 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1278073020371 ligand binding site; other site 1278073020372 oligomer interface; other site 1278073020373 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1278073020374 dimer interface [polypeptide binding]; other site 1278073020375 N-terminal domain interface [polypeptide binding]; other site 1278073020376 sulfate 1 binding site; other site 1278073020377 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1278073020378 active site 1278073020379 catalytic residues [active] 1278073020380 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1278073020381 Beta-lactamase; Region: Beta-lactamase; pfam00144 1278073020382 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1278073020383 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1278073020384 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1278073020385 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1278073020386 Cytochrome P450; Region: p450; cl12078 1278073020387 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1278073020388 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 1278073020389 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1278073020390 Interdomain contacts; other site 1278073020391 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 1278073020392 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 1278073020393 active site 1278073020394 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1278073020395 Chitinase C; Region: ChiC; pfam06483 1278073020396 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1278073020397 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073020398 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1278073020399 DNA binding residues [nucleotide binding] 1278073020400 Putative carbohydrate binding domain; Region: CHB_HEX; cl03918 1278073020401 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 1278073020402 active site 1278073020403 C-terminal Early set domain associated with the catalytic domain of chitobiase (also called N-acetylglucosaminidase); Region: E_set_Chitobiase_C; cd02847 1278073020404 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1278073020405 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1278073020406 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1278073020407 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1278073020408 active site turn [active] 1278073020409 phosphorylation site [posttranslational modification] 1278073020410 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1278073020411 active site turn [active] 1278073020412 phosphorylation site [posttranslational modification] 1278073020413 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1278073020414 HPr interaction site; other site 1278073020415 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1278073020416 active site 1278073020417 phosphorylation site [posttranslational modification] 1278073020418 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1278073020419 dimerization domain swap beta strand [polypeptide binding]; other site 1278073020420 regulatory protein interface [polypeptide binding]; other site 1278073020421 active site 1278073020422 regulatory phosphorylation site [posttranslational modification]; other site 1278073020423 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1278073020424 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1278073020425 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1278073020426 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1278073020427 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 1278073020428 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1278073020429 putative active site [active] 1278073020430 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1278073020431 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1278073020432 DNA-binding site [nucleotide binding]; DNA binding site 1278073020433 UTRA domain; Region: UTRA; pfam07702 1278073020434 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1278073020435 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1278073020436 dimer interface [polypeptide binding]; other site 1278073020437 active site 1278073020438 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1278073020439 dimer interface [polypeptide binding]; other site 1278073020440 active site 1278073020441 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1278073020442 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1278073020443 active site 1278073020444 dimer interface [polypeptide binding]; other site 1278073020445 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 1278073020446 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 1278073020447 Glyco_18 domain; Region: Glyco_18; smart00636 1278073020448 active site 1278073020449 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 1278073020450 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073020451 Walker A/P-loop; other site 1278073020452 ATP binding site [chemical binding]; other site 1278073020453 Q-loop/lid; other site 1278073020454 ABC transporter signature motif; other site 1278073020455 Walker B; other site 1278073020456 D-loop; other site 1278073020457 H-loop/switch region; other site 1278073020458 TOBE domain; Region: TOBE; cl01440 1278073020459 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1278073020460 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1278073020461 dimer interface [polypeptide binding]; other site 1278073020462 conserved gate region; other site 1278073020463 putative PBP binding loops; other site 1278073020464 ABC-ATPase subunit interface; other site 1278073020465 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1278073020466 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1278073020467 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1278073020468 MarR family; Region: MarR; pfam01047 1278073020469 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1278073020470 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1278073020471 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1278073020472 protein binding site [polypeptide binding]; other site 1278073020473 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1278073020474 protein binding site [polypeptide binding]; other site 1278073020475 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1278073020476 putative active site [active] 1278073020477 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 1278073020478 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 1278073020479 prolyl-tRNA synthetase; Provisional; Region: PRK08661 1278073020480 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 1278073020481 dimer interface [polypeptide binding]; other site 1278073020482 motif 1; other site 1278073020483 active site 1278073020484 motif 2; other site 1278073020485 motif 3; other site 1278073020486 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 1278073020487 anticodon binding site; other site 1278073020488 zinc-binding site [ion binding]; other site 1278073020489 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1278073020490 cyclase homology domain; Region: CHD; cd07302 1278073020491 nucleotidyl binding site; other site 1278073020492 metal binding site [ion binding]; metal-binding site 1278073020493 dimer interface [polypeptide binding]; other site 1278073020494 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073020495 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 1278073020496 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073020497 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 1278073020498 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1278073020499 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1278073020500 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 1278073020501 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 1278073020502 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 1278073020503 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 1278073020504 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 1278073020505 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073020506 S-adenosylmethionine binding site [chemical binding]; other site 1278073020507 BNR repeat-like domain; Region: BNR_2; pfam13088 1278073020508 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1278073020509 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1278073020510 Walker A/P-loop; other site 1278073020511 ATP binding site [chemical binding]; other site 1278073020512 Q-loop/lid; other site 1278073020513 ABC transporter signature motif; other site 1278073020514 Walker B; other site 1278073020515 D-loop; other site 1278073020516 H-loop/switch region; other site 1278073020517 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1278073020518 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1278073020519 Walker A/P-loop; other site 1278073020520 ATP binding site [chemical binding]; other site 1278073020521 Q-loop/lid; other site 1278073020522 ABC transporter signature motif; other site 1278073020523 Walker B; other site 1278073020524 D-loop; other site 1278073020525 H-loop/switch region; other site 1278073020526 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1278073020527 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1278073020528 TM-ABC transporter signature motif; other site 1278073020529 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1278073020530 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1278073020531 TM-ABC transporter signature motif; other site 1278073020532 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1278073020533 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 1278073020534 putative ligand binding site [chemical binding]; other site 1278073020535 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 1278073020536 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1278073020537 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073020538 active site 1278073020539 ATP binding site [chemical binding]; other site 1278073020540 substrate binding site [chemical binding]; other site 1278073020541 activation loop (A-loop); other site 1278073020542 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1278073020543 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1278073020544 nucleotide binding site [chemical binding]; other site 1278073020545 NEF interaction site [polypeptide binding]; other site 1278073020546 SBD interface [polypeptide binding]; other site 1278073020547 GrpE; Region: GrpE; pfam01025 1278073020548 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1278073020549 dimer interface [polypeptide binding]; other site 1278073020550 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1278073020551 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1278073020552 putative catalytic site [active] 1278073020553 putative metal binding site [ion binding]; other site 1278073020554 putative phosphate binding site [ion binding]; other site 1278073020555 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1278073020556 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 1278073020557 Receptor L domain; Region: Recep_L_domain; pfam01030 1278073020558 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1278073020559 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073020560 active site 1278073020561 phosphorylation site [posttranslational modification] 1278073020562 intermolecular recognition site; other site 1278073020563 dimerization interface [polypeptide binding]; other site 1278073020564 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1278073020565 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1278073020566 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1278073020567 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1278073020568 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073020569 ATP binding site [chemical binding]; other site 1278073020570 Mg2+ binding site [ion binding]; other site 1278073020571 G-X-G motif; other site 1278073020572 Predicted transcriptional regulators [Transcription]; Region: COG1733 1278073020573 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1278073020574 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1278073020575 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073020576 NAD(P) binding site [chemical binding]; other site 1278073020577 active site 1278073020578 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1278073020579 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1278073020580 ligand binding site [chemical binding]; other site 1278073020581 flexible hinge region; other site 1278073020582 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073020583 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073020584 ATP binding site [chemical binding]; other site 1278073020585 Mg2+ binding site [ion binding]; other site 1278073020586 G-X-G motif; other site 1278073020587 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1278073020588 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1278073020589 ligand binding site [chemical binding]; other site 1278073020590 flexible hinge region; other site 1278073020591 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073020592 ATP binding site [chemical binding]; other site 1278073020593 Mg2+ binding site [ion binding]; other site 1278073020594 G-X-G motif; other site 1278073020595 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 1278073020596 Ycf46; Provisional; Region: ycf46; CHL00195 1278073020597 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073020598 ATP binding site [chemical binding]; other site 1278073020599 Walker A motif; other site 1278073020600 Walker B motif; other site 1278073020601 arginine finger; other site 1278073020602 Protein of unknown function DUF111; Region: DUF111; pfam01969 1278073020603 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 1278073020604 AIR carboxylase; Region: AIRC; smart01001 1278073020605 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 1278073020606 CheC-like family; Region: CheC; pfam04509 1278073020607 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1278073020608 putative binding surface; other site 1278073020609 active site 1278073020610 P2 response regulator binding domain; Region: P2; pfam07194 1278073020611 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1278073020612 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073020613 ATP binding site [chemical binding]; other site 1278073020614 Mg2+ binding site [ion binding]; other site 1278073020615 G-X-G motif; other site 1278073020616 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1278073020617 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073020618 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073020619 active site 1278073020620 phosphorylation site [posttranslational modification] 1278073020621 intermolecular recognition site; other site 1278073020622 dimerization interface [polypeptide binding]; other site 1278073020623 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 1278073020624 Protein of unknown function (DUF419); Region: DUF419; pfam04237 1278073020625 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1278073020626 dimerization interface [polypeptide binding]; other site 1278073020627 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1278073020628 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1278073020629 dimer interface [polypeptide binding]; other site 1278073020630 putative CheW interface [polypeptide binding]; other site 1278073020631 thiamine monophosphate kinase; Provisional; Region: PRK05731 1278073020632 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1278073020633 ATP binding site [chemical binding]; other site 1278073020634 dimerization interface [polypeptide binding]; other site 1278073020635 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 1278073020636 protein-splicing catalytic site; other site 1278073020637 thioester formation/cholesterol transfer; other site 1278073020638 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1278073020639 hydrophobic ligand binding site; other site 1278073020640 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1278073020641 dimerization interface [polypeptide binding]; other site 1278073020642 putative DNA binding site [nucleotide binding]; other site 1278073020643 putative Zn2+ binding site [ion binding]; other site 1278073020644 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 1278073020645 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1278073020646 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073020647 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073020648 active site 1278073020649 ATP binding site [chemical binding]; other site 1278073020650 substrate binding site [chemical binding]; other site 1278073020651 activation loop (A-loop); other site 1278073020652 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073020653 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1278073020654 binding surface 1278073020655 TPR motif; other site 1278073020656 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1278073020657 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1278073020658 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1278073020659 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073020660 binding surface 1278073020661 TPR motif; other site 1278073020662 RNA polymerase sigma-70 factor, Myxococcales family 1; Region: Sig-70_gmx1; TIGR03001 1278073020663 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1278073020664 DNA binding residues [nucleotide binding] 1278073020665 LabA_like proteins; Region: LabA_like; cd06167 1278073020666 putative metal binding site [ion binding]; other site 1278073020667 Sensory domain found in PocR; Region: PocR; pfam10114 1278073020668 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073020669 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073020670 dimer interface [polypeptide binding]; other site 1278073020671 phosphorylation site [posttranslational modification] 1278073020672 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073020673 ATP binding site [chemical binding]; other site 1278073020674 Mg2+ binding site [ion binding]; other site 1278073020675 G-X-G motif; other site 1278073020676 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 1278073020677 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1278073020678 G1 box; other site 1278073020679 GTP/Mg2+ binding site [chemical binding]; other site 1278073020680 G2 box; other site 1278073020681 Switch I region; other site 1278073020682 G3 box; other site 1278073020683 Switch II region; other site 1278073020684 G4 box; other site 1278073020685 G5 box; other site 1278073020686 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1278073020687 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1278073020688 Coenzyme A binding pocket [chemical binding]; other site 1278073020689 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1278073020690 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1278073020691 Walker A motif; other site 1278073020692 ATP binding site [chemical binding]; other site 1278073020693 Walker B motif; other site 1278073020694 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1278073020695 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1278073020696 Walker A motif; other site 1278073020697 ATP binding site [chemical binding]; other site 1278073020698 Walker B motif; other site 1278073020699 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1278073020700 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1278073020701 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1278073020702 active site 1278073020703 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1278073020704 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1278073020705 N-terminal plug; other site 1278073020706 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 1278073020707 ligand-binding site [chemical binding]; other site 1278073020708 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1278073020709 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1278073020710 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1278073020711 Peptidase family M50; Region: Peptidase_M50; pfam02163 1278073020712 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 1278073020713 active site 1278073020714 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1278073020715 putative substrate binding region [chemical binding]; other site 1278073020716 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1278073020717 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1278073020718 motif II; other site 1278073020719 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1278073020720 putative lipid kinase; Reviewed; Region: PRK13057 1278073020721 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1278073020722 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1278073020723 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1278073020724 EamA-like transporter family; Region: EamA; pfam00892 1278073020725 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073020726 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073020727 active site 1278073020728 phosphorylation site [posttranslational modification] 1278073020729 intermolecular recognition site; other site 1278073020730 dimerization interface [polypeptide binding]; other site 1278073020731 PAS domain S-box; Region: sensory_box; TIGR00229 1278073020732 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1278073020733 putative active site [active] 1278073020734 heme pocket [chemical binding]; other site 1278073020735 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1278073020736 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1278073020737 putative active site [active] 1278073020738 heme pocket [chemical binding]; other site 1278073020739 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073020740 phosphorylation site [posttranslational modification] 1278073020741 dimer interface [polypeptide binding]; other site 1278073020742 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073020743 ATP binding site [chemical binding]; other site 1278073020744 Mg2+ binding site [ion binding]; other site 1278073020745 G-X-G motif; other site 1278073020746 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1278073020747 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1278073020748 dimerization interface [polypeptide binding]; other site 1278073020749 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1278073020750 dimerization interface [polypeptide binding]; other site 1278073020751 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1278073020752 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1278073020753 dimerization interface [polypeptide binding]; other site 1278073020754 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1278073020755 dimerization interface [polypeptide binding]; other site 1278073020756 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1278073020757 dimerization interface [polypeptide binding]; other site 1278073020758 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1278073020759 dimerization interface [polypeptide binding]; other site 1278073020760 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1278073020761 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1278073020762 dimerization interface [polypeptide binding]; other site 1278073020763 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1278073020764 dimerization interface [polypeptide binding]; other site 1278073020765 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1278073020766 dimerization interface [polypeptide binding]; other site 1278073020767 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1278073020768 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1278073020769 dimerization interface [polypeptide binding]; other site 1278073020770 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1278073020771 dimerization interface [polypeptide binding]; other site 1278073020772 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1278073020773 dimerization interface [polypeptide binding]; other site 1278073020774 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1278073020775 dimerization interface [polypeptide binding]; other site 1278073020776 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1278073020777 dimerization interface [polypeptide binding]; other site 1278073020778 GAF domain; Region: GAF_2; pfam13185 1278073020779 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073020780 dimer interface [polypeptide binding]; other site 1278073020781 phosphorylation site [posttranslational modification] 1278073020782 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073020783 ATP binding site [chemical binding]; other site 1278073020784 Mg2+ binding site [ion binding]; other site 1278073020785 G-X-G motif; other site 1278073020786 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073020787 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073020788 active site 1278073020789 phosphorylation site [posttranslational modification] 1278073020790 intermolecular recognition site; other site 1278073020791 dimerization interface [polypeptide binding]; other site 1278073020792 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073020793 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073020794 phosphorylation site [posttranslational modification] 1278073020795 intermolecular recognition site; other site 1278073020796 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073020797 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073020798 active site 1278073020799 phosphorylation site [posttranslational modification] 1278073020800 intermolecular recognition site; other site 1278073020801 dimerization interface [polypeptide binding]; other site 1278073020802 trigger factor; Region: tig; TIGR00115 1278073020803 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1278073020804 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1278073020805 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 1278073020806 trigger factor; Region: tig; TIGR00115 1278073020807 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1278073020808 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1278073020809 proposed catalytic triad [active] 1278073020810 conserved cys residue [active] 1278073020811 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1278073020812 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1278073020813 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1278073020814 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1278073020815 TrkA-N domain; Region: TrkA_N; pfam02254 1278073020816 TrkA-C domain; Region: TrkA_C; pfam02080 1278073020817 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1278073020818 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1278073020819 ligand binding site [chemical binding]; other site 1278073020820 flexible hinge region; other site 1278073020821 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1278073020822 TPR motif; other site 1278073020823 binding surface 1278073020824 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073020825 TPR motif; other site 1278073020826 TPR repeat; Region: TPR_11; pfam13414 1278073020827 binding surface 1278073020828 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1278073020829 catalytic residues [active] 1278073020830 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 1278073020831 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 1278073020832 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1278073020833 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1278073020834 PAS fold; Region: PAS_3; pfam08447 1278073020835 putative active site [active] 1278073020836 heme pocket [chemical binding]; other site 1278073020837 PAS domain; Region: PAS_8; pfam13188 1278073020838 PAS fold; Region: PAS_7; pfam12860 1278073020839 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1278073020840 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073020841 ATP binding site [chemical binding]; other site 1278073020842 Mg2+ binding site [ion binding]; other site 1278073020843 G-X-G motif; other site 1278073020844 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 1278073020845 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 1278073020846 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1278073020847 putative active site [active] 1278073020848 putative active site [active] 1278073020849 catalytic site [active] 1278073020850 catalytic site [active] 1278073020851 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 1278073020852 putative active site [active] 1278073020853 catalytic site [active] 1278073020854 Putative zinc-finger; Region: zf-HC2; pfam13490 1278073020855 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1278073020856 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073020857 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1278073020858 DNA binding residues [nucleotide binding] 1278073020859 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1278073020860 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1278073020861 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 1278073020862 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1278073020863 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1278073020864 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1278073020865 Walker A/P-loop; other site 1278073020866 ATP binding site [chemical binding]; other site 1278073020867 Q-loop/lid; other site 1278073020868 ABC transporter signature motif; other site 1278073020869 Walker B; other site 1278073020870 D-loop; other site 1278073020871 H-loop/switch region; other site 1278073020872 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1278073020873 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1278073020874 FtsX-like permease family; Region: FtsX; pfam02687 1278073020875 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 1278073020876 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1278073020877 active site 1278073020878 glycerol kinase; Provisional; Region: glpK; PRK00047 1278073020879 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1278073020880 N- and C-terminal domain interface [polypeptide binding]; other site 1278073020881 active site 1278073020882 MgATP binding site [chemical binding]; other site 1278073020883 catalytic site [active] 1278073020884 metal binding site [ion binding]; metal-binding site 1278073020885 glycerol binding site [chemical binding]; other site 1278073020886 homotetramer interface [polypeptide binding]; other site 1278073020887 homodimer interface [polypeptide binding]; other site 1278073020888 FBP binding site [chemical binding]; other site 1278073020889 protein IIAGlc interface [polypeptide binding]; other site 1278073020890 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1278073020891 aromatic arch; other site 1278073020892 DCoH dimer interaction site [polypeptide binding]; other site 1278073020893 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1278073020894 DCoH tetramer interaction site [polypeptide binding]; other site 1278073020895 substrate binding site [chemical binding]; other site 1278073020896 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1278073020897 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 1278073020898 metal binding site [ion binding]; metal-binding site 1278073020899 putative dimer interface [polypeptide binding]; other site 1278073020900 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1278073020901 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1278073020902 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 1278073020903 Domain of unknown function (DUF2828); Region: DUF2828; pfam11443 1278073020904 anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451 1278073020905 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 1278073020906 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 1278073020907 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1278073020908 trimer interface [polypeptide binding]; other site 1278073020909 active site 1278073020910 substrate binding site [chemical binding]; other site 1278073020911 CoA binding site [chemical binding]; other site 1278073020912 Rdx family; Region: Rdx; pfam10262 1278073020913 tyrosine decarboxylase; Region: PLN02880 1278073020914 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1278073020915 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1278073020916 catalytic residue [active] 1278073020917 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073020918 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073020919 dimer interface [polypeptide binding]; other site 1278073020920 phosphorylation site [posttranslational modification] 1278073020921 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073020922 ATP binding site [chemical binding]; other site 1278073020923 Mg2+ binding site [ion binding]; other site 1278073020924 G-X-G motif; other site 1278073020925 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073020926 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073020927 active site 1278073020928 phosphorylation site [posttranslational modification] 1278073020929 intermolecular recognition site; other site 1278073020930 dimerization interface [polypeptide binding]; other site 1278073020931 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073020932 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073020933 dimer interface [polypeptide binding]; other site 1278073020934 phosphorylation site [posttranslational modification] 1278073020935 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073020936 ATP binding site [chemical binding]; other site 1278073020937 Mg2+ binding site [ion binding]; other site 1278073020938 G-X-G motif; other site 1278073020939 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1278073020940 Ligand binding site; other site 1278073020941 Putative Catalytic site; other site 1278073020942 DXD motif; other site 1278073020943 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1278073020944 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1278073020945 TrkA-C domain; Region: TrkA_C; pfam02080 1278073020946 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 1278073020947 rod shape-determining protein MreB; Provisional; Region: PRK13927 1278073020948 MreB and similar proteins; Region: MreB_like; cd10225 1278073020949 nucleotide binding site [chemical binding]; other site 1278073020950 Mg binding site [ion binding]; other site 1278073020951 putative protofilament interaction site [polypeptide binding]; other site 1278073020952 RodZ interaction site [polypeptide binding]; other site 1278073020953 Domain of unknown function (DUF4412); Region: DUF4412; pfam14371 1278073020954 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1278073020955 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1278073020956 C-terminal domain interface [polypeptide binding]; other site 1278073020957 GSH binding site (G-site) [chemical binding]; other site 1278073020958 dimer interface [polypeptide binding]; other site 1278073020959 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 1278073020960 ADP-ribose binding site [chemical binding]; other site 1278073020961 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 1278073020962 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1278073020963 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1278073020964 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1278073020965 Walker A/P-loop; other site 1278073020966 ATP binding site [chemical binding]; other site 1278073020967 Q-loop/lid; other site 1278073020968 ABC transporter signature motif; other site 1278073020969 Walker B; other site 1278073020970 D-loop; other site 1278073020971 H-loop/switch region; other site 1278073020972 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1278073020973 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073020974 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073020975 active site 1278073020976 ATP binding site [chemical binding]; other site 1278073020977 substrate binding site [chemical binding]; other site 1278073020978 activation loop (A-loop); other site 1278073020979 AAA ATPase domain; Region: AAA_16; pfam13191 1278073020980 AAA domain; Region: AAA_22; pfam13401 1278073020981 Protein of unknown function (DUF2185); Region: DUF2185; cl02019 1278073020982 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 1278073020983 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1278073020984 MG2 domain; Region: A2M_N; pfam01835 1278073020985 MG2 domain; Region: A2M_N; pfam01835 1278073020986 Alpha-2-macroglobulin family; Region: A2M; pfam00207 1278073020987 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 1278073020988 surface patch; other site 1278073020989 thioester region; other site 1278073020990 specificity defining residues; other site 1278073020991 Biofilm formation and stress response factor; Region: BsmA; pfam10014 1278073020992 LysR family transcriptional regulator; Provisional; Region: PRK14997 1278073020993 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1278073020994 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1278073020995 putative effector binding pocket; other site 1278073020996 dimerization interface [polypeptide binding]; other site 1278073020997 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 1278073020998 SnoaL-like domain; Region: SnoaL_3; pfam13474 1278073020999 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1278073021000 Transglycosylase; Region: Transgly; pfam00912 1278073021001 MASE1; Region: MASE1; cl17823 1278073021002 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073021003 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073021004 dimer interface [polypeptide binding]; other site 1278073021005 phosphorylation site [posttranslational modification] 1278073021006 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073021007 ATP binding site [chemical binding]; other site 1278073021008 Mg2+ binding site [ion binding]; other site 1278073021009 G-X-G motif; other site 1278073021010 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 1278073021011 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 1278073021012 Zn binding site [ion binding]; other site 1278073021013 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1278073021014 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1278073021015 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 1278073021016 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1278073021017 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1278073021018 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1278073021019 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073021020 Walker A/P-loop; other site 1278073021021 ATP binding site [chemical binding]; other site 1278073021022 Q-loop/lid; other site 1278073021023 ABC transporter signature motif; other site 1278073021024 Walker B; other site 1278073021025 D-loop; other site 1278073021026 H-loop/switch region; other site 1278073021027 TAP-like protein; Region: Abhydrolase_4; pfam08386 1278073021028 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1278073021029 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 1278073021030 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 1278073021031 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1278073021032 tetramerization interface [polypeptide binding]; other site 1278073021033 active site 1278073021034 EcsC protein family; Region: EcsC; pfam12787 1278073021035 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1278073021036 Bacterial Ig-like domain; Region: Big_5; pfam13205 1278073021037 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1278073021038 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1278073021039 ligand binding site [chemical binding]; other site 1278073021040 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1278073021041 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1278073021042 Protein of unknown function (DUF2378); Region: DUF2378; cl15288 1278073021043 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1278073021044 catalytic residues [active] 1278073021045 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1278073021046 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1278073021047 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 1278073021048 NAD synthetase; Provisional; Region: PRK13981 1278073021049 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1278073021050 multimer interface [polypeptide binding]; other site 1278073021051 active site 1278073021052 catalytic triad [active] 1278073021053 protein interface 1 [polypeptide binding]; other site 1278073021054 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1278073021055 homodimer interface [polypeptide binding]; other site 1278073021056 NAD binding pocket [chemical binding]; other site 1278073021057 ATP binding pocket [chemical binding]; other site 1278073021058 Mg binding site [ion binding]; other site 1278073021059 active-site loop [active] 1278073021060 Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802 1278073021061 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1278073021062 Beta-lactamase; Region: Beta-lactamase; pfam00144 1278073021063 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1278073021064 Cupin; Region: Cupin_6; pfam12852 1278073021065 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1278073021066 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1278073021067 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1278073021068 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1278073021069 NAD(P) binding site [chemical binding]; other site 1278073021070 MASE1; Region: MASE1; pfam05231 1278073021071 PAS domain; Region: PAS_9; pfam13426 1278073021072 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1278073021073 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073021074 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1278073021075 phosphorylation site [posttranslational modification] 1278073021076 dimer interface [polypeptide binding]; other site 1278073021077 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073021078 ATP binding site [chemical binding]; other site 1278073021079 Mg2+ binding site [ion binding]; other site 1278073021080 G-X-G motif; other site 1278073021081 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073021082 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073021083 active site 1278073021084 phosphorylation site [posttranslational modification] 1278073021085 intermolecular recognition site; other site 1278073021086 dimerization interface [polypeptide binding]; other site 1278073021087 TM2 domain; Region: TM2; cl00984 1278073021088 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 1278073021089 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1278073021090 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1278073021091 motif II; other site 1278073021092 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1278073021093 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1278073021094 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1278073021095 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1278073021096 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1278073021097 bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550 1278073021098 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1278073021099 GAF domain; Region: GAF; cl17456 1278073021100 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1278073021101 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073021102 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1278073021103 putative active site [active] 1278073021104 heme pocket [chemical binding]; other site 1278073021105 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073021106 dimer interface [polypeptide binding]; other site 1278073021107 phosphorylation site [posttranslational modification] 1278073021108 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073021109 ATP binding site [chemical binding]; other site 1278073021110 Mg2+ binding site [ion binding]; other site 1278073021111 G-X-G motif; other site 1278073021112 GAF domain; Region: GAF; cl17456 1278073021113 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1278073021114 PAS domain; Region: PAS_9; pfam13426 1278073021115 putative active site [active] 1278073021116 heme pocket [chemical binding]; other site 1278073021117 PAS domain S-box; Region: sensory_box; TIGR00229 1278073021118 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1278073021119 putative active site [active] 1278073021120 heme pocket [chemical binding]; other site 1278073021121 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073021122 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073021123 dimer interface [polypeptide binding]; other site 1278073021124 phosphorylation site [posttranslational modification] 1278073021125 malonic semialdehyde reductase; Provisional; Region: PRK10538 1278073021126 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 1278073021127 putative NAD(P) binding site [chemical binding]; other site 1278073021128 homodimer interface [polypeptide binding]; other site 1278073021129 homotetramer interface [polypeptide binding]; other site 1278073021130 active site 1278073021131 Predicted membrane protein [Function unknown]; Region: COG2259 1278073021132 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E); Region: PHA_synth_III_E; cl09914 1278073021133 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 1278073021134 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 1278073021135 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1278073021136 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 1278073021137 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 1278073021138 Dihydroneopterin aldolase; Region: FolB; pfam02152 1278073021139 active site 1278073021140 Cupin domain; Region: Cupin_2; cl17218 1278073021141 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073021142 S-adenosylmethionine binding site [chemical binding]; other site 1278073021143 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1278073021144 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1278073021145 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 1278073021146 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1278073021147 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 1278073021148 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1278073021149 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1278073021150 DNA binding residues [nucleotide binding] 1278073021151 dimerization interface [polypeptide binding]; other site 1278073021152 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1278073021153 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1278073021154 catalytic residues [active] 1278073021155 Thioredoxin-like; Region: Thioredoxin_7; pfam13899 1278073021156 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1278073021157 G1 box; other site 1278073021158 GTP/Mg2+ binding site [chemical binding]; other site 1278073021159 G2 box; other site 1278073021160 Switch I region; other site 1278073021161 G3 box; other site 1278073021162 Switch II region; other site 1278073021163 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1278073021164 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1278073021165 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1278073021166 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1278073021167 ligand binding site [chemical binding]; other site 1278073021168 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1278073021169 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1278073021170 Zn2+ binding site [ion binding]; other site 1278073021171 Mg2+ binding site [ion binding]; other site 1278073021172 HEAT repeats; Region: HEAT_2; pfam13646 1278073021173 HEAT repeats; Region: HEAT_2; pfam13646 1278073021174 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073021175 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073021176 active site 1278073021177 ATP binding site [chemical binding]; other site 1278073021178 substrate binding site [chemical binding]; other site 1278073021179 activation loop (A-loop); other site 1278073021180 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1278073021181 Double zinc ribbon; Region: DZR; pfam12773 1278073021182 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1278073021183 cyclase homology domain; Region: CHD; cd07302 1278073021184 nucleotidyl binding site; other site 1278073021185 metal binding site [ion binding]; metal-binding site 1278073021186 dimer interface [polypeptide binding]; other site 1278073021187 Protein of unknown function, DUF393; Region: DUF393; pfam04134 1278073021188 Lipase maturation factor; Region: LMF1; pfam06762 1278073021189 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1278073021190 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1278073021191 active site 1278073021192 catalytic site [active] 1278073021193 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1278073021194 Amidinotransferase; Region: Amidinotransf; cl12043 1278073021195 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1278073021196 GTP/Mg2+ binding site [chemical binding]; other site 1278073021197 G2 box; other site 1278073021198 Switch I region; other site 1278073021199 G3 box; other site 1278073021200 Switch II region; other site 1278073021201 G4 box; other site 1278073021202 G5 box; other site 1278073021203 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1278073021204 Peptidase family M23; Region: Peptidase_M23; pfam01551 1278073021205 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1278073021206 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1278073021207 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 1278073021208 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 1278073021209 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 1278073021210 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1278073021211 active site 1278073021212 dimer interface [polypeptide binding]; other site 1278073021213 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1278073021214 dimer interface [polypeptide binding]; other site 1278073021215 active site 1278073021216 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1278073021217 short chain dehydrogenase; Provisional; Region: PRK06180 1278073021218 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1278073021219 NADP binding site [chemical binding]; other site 1278073021220 active site 1278073021221 steroid binding site; other site 1278073021222 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1278073021223 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1278073021224 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1278073021225 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1278073021226 dimerization interface [polypeptide binding]; other site 1278073021227 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 1278073021228 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1278073021229 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1278073021230 classical (c) SDRs; Region: SDR_c; cd05233 1278073021231 NAD(P) binding site [chemical binding]; other site 1278073021232 active site 1278073021233 WGR domain; Region: WGR; cl01581 1278073021234 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1278073021235 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1278073021236 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1278073021237 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1278073021238 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1278073021239 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1278073021240 Predicted transcriptional regulator [Transcription]; Region: COG1959 1278073021241 Transcriptional regulator; Region: Rrf2; cl17282 1278073021242 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 1278073021243 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1278073021244 catalytic loop [active] 1278073021245 iron binding site [ion binding]; other site 1278073021246 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194 1278073021247 FAD binding pocket [chemical binding]; other site 1278073021248 FAD binding motif [chemical binding]; other site 1278073021249 phosphate binding motif [ion binding]; other site 1278073021250 beta-alpha-beta structure motif; other site 1278073021251 NAD binding pocket [chemical binding]; other site 1278073021252 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1278073021253 apolar tunnel; other site 1278073021254 heme binding site [chemical binding]; other site 1278073021255 dimerization interface [polypeptide binding]; other site 1278073021256 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1278073021257 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1278073021258 dimerization interface [polypeptide binding]; other site 1278073021259 putative DNA binding site [nucleotide binding]; other site 1278073021260 putative Zn2+ binding site [ion binding]; other site 1278073021261 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1278073021262 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1278073021263 gamma subunit interface [polypeptide binding]; other site 1278073021264 epsilon subunit interface [polypeptide binding]; other site 1278073021265 LBP interface [polypeptide binding]; other site 1278073021266 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1278073021267 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1278073021268 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1278073021269 alpha subunit interaction interface [polypeptide binding]; other site 1278073021270 Walker A motif; other site 1278073021271 ATP binding site [chemical binding]; other site 1278073021272 Walker B motif; other site 1278073021273 inhibitor binding site; inhibition site 1278073021274 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1278073021275 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1278073021276 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1278073021277 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1278073021278 core domain interface [polypeptide binding]; other site 1278073021279 delta subunit interface [polypeptide binding]; other site 1278073021280 epsilon subunit interface [polypeptide binding]; other site 1278073021281 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073021282 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073021283 active site 1278073021284 phosphorylation site [posttranslational modification] 1278073021285 intermolecular recognition site; other site 1278073021286 dimerization interface [polypeptide binding]; other site 1278073021287 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1278073021288 putative active site [active] 1278073021289 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 1278073021290 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1278073021291 catalytic residues [active] 1278073021292 conserved hypothetical protein; Region: TIGR02270 1278073021293 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1278073021294 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1278073021295 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1278073021296 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1278073021297 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1278073021298 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1278073021299 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1278073021300 Active site serine [active] 1278073021301 Right handed beta helix region; Region: Beta_helix; pfam13229 1278073021302 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 1278073021303 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1278073021304 conserved cys residue [active] 1278073021305 Yersinia/Haemophilus virulence surface antigen; Region: Peptidase_C58; cl04145 1278073021306 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1278073021307 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073021308 Walker A/P-loop; other site 1278073021309 ATP binding site [chemical binding]; other site 1278073021310 Q-loop/lid; other site 1278073021311 ABC transporter signature motif; other site 1278073021312 Walker B; other site 1278073021313 D-loop; other site 1278073021314 H-loop/switch region; other site 1278073021315 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1278073021316 Ligand Binding Site [chemical binding]; other site 1278073021317 CsbD-like; Region: CsbD; pfam05532 1278073021318 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1278073021319 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 1278073021320 active site 1278073021321 active site 1278073021322 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1278073021323 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1278073021324 dimer interface [polypeptide binding]; other site 1278073021325 putative CheW interface [polypeptide binding]; other site 1278073021326 phytoene desaturase; Region: crtI_fam; TIGR02734 1278073021327 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1278073021328 CHASE domain; Region: CHASE; pfam03924 1278073021329 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073021330 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073021331 ATP binding site [chemical binding]; other site 1278073021332 Mg2+ binding site [ion binding]; other site 1278073021333 G-X-G motif; other site 1278073021334 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1278073021335 Kelch domain; Region: Kelch; smart00612 1278073021336 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1278073021337 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 1278073021338 Kelch domain; Region: Kelch; smart00612 1278073021339 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1278073021340 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1278073021341 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073021342 S-adenosylmethionine binding site [chemical binding]; other site 1278073021343 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1278073021344 dimer interface [polypeptide binding]; other site 1278073021345 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 1278073021346 short chain dehydrogenase; Provisional; Region: PRK06179 1278073021347 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1278073021348 NADP binding site [chemical binding]; other site 1278073021349 active site 1278073021350 steroid binding site; other site 1278073021351 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1278073021352 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1278073021353 CheW-like domain; Region: CheW; pfam01584 1278073021354 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1278073021355 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1278073021356 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 1278073021357 CHASE3 domain; Region: CHASE3; pfam05227 1278073021358 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1278073021359 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1278073021360 dimerization interface [polypeptide binding]; other site 1278073021361 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1278073021362 dimer interface [polypeptide binding]; other site 1278073021363 putative CheW interface [polypeptide binding]; other site 1278073021364 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1278073021365 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1278073021366 putative binding surface; other site 1278073021367 active site 1278073021368 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073021369 ATP binding site [chemical binding]; other site 1278073021370 Mg2+ binding site [ion binding]; other site 1278073021371 G-X-G motif; other site 1278073021372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073021373 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073021374 active site 1278073021375 phosphorylation site [posttranslational modification] 1278073021376 intermolecular recognition site; other site 1278073021377 dimerization interface [polypeptide binding]; other site 1278073021378 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1278073021379 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073021380 active site 1278073021381 phosphorylation site [posttranslational modification] 1278073021382 intermolecular recognition site; other site 1278073021383 dimerization interface [polypeptide binding]; other site 1278073021384 CheB methylesterase; Region: CheB_methylest; pfam01339 1278073021385 PAS fold; Region: PAS_4; pfam08448 1278073021386 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1278073021387 putative active site [active] 1278073021388 heme pocket [chemical binding]; other site 1278073021389 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1278073021390 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1278073021391 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073021392 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073021393 dimer interface [polypeptide binding]; other site 1278073021394 phosphorylation site [posttranslational modification] 1278073021395 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073021396 ATP binding site [chemical binding]; other site 1278073021397 Mg2+ binding site [ion binding]; other site 1278073021398 G-X-G motif; other site 1278073021399 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1278073021400 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1278073021401 TrkA-C domain; Region: TrkA_C; pfam02080 1278073021402 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1278073021403 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1278073021404 active site 1278073021405 catalytic residues [active] 1278073021406 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 1278073021407 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 1278073021408 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1278073021409 TrkA-N domain; Region: TrkA_N; pfam02254 1278073021410 PAS domain; Region: PAS; smart00091 1278073021411 PAS domain; Region: PAS; smart00091 1278073021412 PAS fold; Region: PAS_4; pfam08448 1278073021413 putative active site [active] 1278073021414 heme pocket [chemical binding]; other site 1278073021415 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073021416 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073021417 dimer interface [polypeptide binding]; other site 1278073021418 phosphorylation site [posttranslational modification] 1278073021419 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073021420 ATP binding site [chemical binding]; other site 1278073021421 Mg2+ binding site [ion binding]; other site 1278073021422 G-X-G motif; other site 1278073021423 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1278073021424 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073021425 active site 1278073021426 phosphorylation site [posttranslational modification] 1278073021427 intermolecular recognition site; other site 1278073021428 dimerization interface [polypeptide binding]; other site 1278073021429 PilZ domain; Region: PilZ; cl01260 1278073021430 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1278073021431 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1278073021432 putative di-iron ligands [ion binding]; other site 1278073021433 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073021434 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073021435 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073021436 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073021437 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073021438 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073021439 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073021440 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1278073021441 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1278073021442 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 1278073021443 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 1278073021444 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1278073021445 metal binding site 2 [ion binding]; metal-binding site 1278073021446 putative DNA binding helix; other site 1278073021447 metal binding site 1 [ion binding]; metal-binding site 1278073021448 dimer interface [polypeptide binding]; other site 1278073021449 structural Zn2+ binding site [ion binding]; other site 1278073021450 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1278073021451 active site 1278073021452 PAS fold; Region: PAS_4; pfam08448 1278073021453 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073021454 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073021455 dimer interface [polypeptide binding]; other site 1278073021456 phosphorylation site [posttranslational modification] 1278073021457 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073021458 ATP binding site [chemical binding]; other site 1278073021459 Mg2+ binding site [ion binding]; other site 1278073021460 G-X-G motif; other site 1278073021461 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1278073021462 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1278073021463 putative active site [active] 1278073021464 putative metal binding site [ion binding]; other site 1278073021465 Predicted membrane protein [Function unknown]; Region: COG2259 1278073021466 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 1278073021467 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073021468 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073021469 ATP binding site [chemical binding]; other site 1278073021470 Mg2+ binding site [ion binding]; other site 1278073021471 G-X-G motif; other site 1278073021472 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 1278073021473 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073021474 active site 1278073021475 phosphorylation site [posttranslational modification] 1278073021476 intermolecular recognition site; other site 1278073021477 dimerization interface [polypeptide binding]; other site 1278073021478 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1278073021479 hypothetical protein; Validated; Region: PRK09039 1278073021480 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1278073021481 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1278073021482 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 1278073021483 AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052 1278073021484 GLTT repeat (6 copies); Region: GLTT; pfam01744 1278073021485 PAS fold; Region: PAS_3; pfam08447 1278073021486 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1278073021487 PAS fold; Region: PAS_3; pfam08447 1278073021488 putative active site [active] 1278073021489 heme pocket [chemical binding]; other site 1278073021490 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073021491 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073021492 phosphorylation site [posttranslational modification] 1278073021493 dimer interface [polypeptide binding]; other site 1278073021494 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073021495 ATP binding site [chemical binding]; other site 1278073021496 Mg2+ binding site [ion binding]; other site 1278073021497 G-X-G motif; other site 1278073021498 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073021499 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073021500 active site 1278073021501 phosphorylation site [posttranslational modification] 1278073021502 intermolecular recognition site; other site 1278073021503 dimerization interface [polypeptide binding]; other site 1278073021504 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1278073021505 GAF domain; Region: GAF_2; pfam13185 1278073021506 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073021507 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073021508 dimer interface [polypeptide binding]; other site 1278073021509 phosphorylation site [posttranslational modification] 1278073021510 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073021511 ATP binding site [chemical binding]; other site 1278073021512 Mg2+ binding site [ion binding]; other site 1278073021513 G-X-G motif; other site 1278073021514 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1278073021515 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 1278073021516 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1278073021517 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1278073021518 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1278073021519 non-specific DNA binding site [nucleotide binding]; other site 1278073021520 salt bridge; other site 1278073021521 sequence-specific DNA binding site [nucleotide binding]; other site 1278073021522 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1278073021523 active site 1278073021524 ATP binding site [chemical binding]; other site 1278073021525 substrate binding site [chemical binding]; other site 1278073021526 activation loop (A-loop); other site 1278073021527 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073021528 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073021529 active site 1278073021530 phosphorylation site [posttranslational modification] 1278073021531 intermolecular recognition site; other site 1278073021532 dimerization interface [polypeptide binding]; other site 1278073021533 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1278073021534 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1278073021535 PAS domain; Region: PAS_9; pfam13426 1278073021536 putative active site [active] 1278073021537 heme pocket [chemical binding]; other site 1278073021538 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1278073021539 PAS domain; Region: PAS_9; pfam13426 1278073021540 putative active site [active] 1278073021541 heme pocket [chemical binding]; other site 1278073021542 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073021543 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073021544 dimer interface [polypeptide binding]; other site 1278073021545 phosphorylation site [posttranslational modification] 1278073021546 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073021547 ATP binding site [chemical binding]; other site 1278073021548 Mg2+ binding site [ion binding]; other site 1278073021549 G-X-G motif; other site 1278073021550 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 1278073021551 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1278073021552 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 1278073021553 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 1278073021554 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 1278073021555 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cd09689 1278073021556 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004 1278073021557 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09651 1278073021558 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1278073021559 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1278073021560 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 1278073021561 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1278073021562 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1278073021563 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 1278073021564 NAD(P) binding site [chemical binding]; other site 1278073021565 catalytic residues [active] 1278073021566 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 1278073021567 Putative esterase; Region: Esterase; pfam00756 1278073021568 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1278073021569 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1278073021570 cation binding site [ion binding]; other site 1278073021571 Beta propeller domain; Region: Beta_propel; pfam09826 1278073021572 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073021573 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073021574 active site 1278073021575 phosphorylation site [posttranslational modification] 1278073021576 intermolecular recognition site; other site 1278073021577 dimerization interface [polypeptide binding]; other site 1278073021578 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1278073021579 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1278073021580 PilZ domain; Region: PilZ; cl01260 1278073021581 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1278073021582 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 1278073021583 nucleotide binding site [chemical binding]; other site 1278073021584 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1278073021585 SBD interface [polypeptide binding]; other site 1278073021586 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 1278073021587 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1278073021588 PAS fold; Region: PAS_4; pfam08448 1278073021589 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1278073021590 PAS domain; Region: PAS_9; pfam13426 1278073021591 putative active site [active] 1278073021592 heme pocket [chemical binding]; other site 1278073021593 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073021594 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073021595 dimer interface [polypeptide binding]; other site 1278073021596 phosphorylation site [posttranslational modification] 1278073021597 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073021598 ATP binding site [chemical binding]; other site 1278073021599 Mg2+ binding site [ion binding]; other site 1278073021600 G-X-G motif; other site 1278073021601 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1278073021602 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1278073021603 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1278073021604 beta subunit interaction interface [polypeptide binding]; other site 1278073021605 Walker A motif; other site 1278073021606 ATP binding site [chemical binding]; other site 1278073021607 Walker B motif; other site 1278073021608 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1278073021609 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1278073021610 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 1278073021611 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1278073021612 Ligand binding site; other site 1278073021613 metal-binding site 1278073021614 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1278073021615 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1278073021616 active site 1278073021617 nucleophile elbow; other site 1278073021618 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 1278073021619 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1278073021620 ligand binding site [chemical binding]; other site 1278073021621 Bacterial virulence factor lipase N-terminal; Region: Lipase_bact_N; pfam12262 1278073021622 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 1278073021623 TPR repeat; Region: TPR_11; pfam13414 1278073021624 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1278073021625 binding surface 1278073021626 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1278073021627 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1278073021628 ligand binding site [chemical binding]; other site 1278073021629 flexible hinge region; other site 1278073021630 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1278073021631 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1278073021632 ligand binding site [chemical binding]; other site 1278073021633 flexible hinge region; other site 1278073021634 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1278073021635 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1278073021636 ligand binding site [chemical binding]; other site 1278073021637 flexible hinge region; other site 1278073021638 VPS10 domain; Region: VPS10; smart00602 1278073021639 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 1278073021640 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1278073021641 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 1278073021642 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cl00653 1278073021643 Active_site [active] 1278073021644 Beta propeller domain; Region: Beta_propel; pfam09826 1278073021645 Uncharacterized conserved protein (DUF2203); Region: DUF2203; pfam09969 1278073021646 Polycystin cation channel protein; Provisional; Region: PLN03223 1278073021647 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 1278073021648 NmrA-like family; Region: NmrA; pfam05368 1278073021649 NADP binding site [chemical binding]; other site 1278073021650 active site 1278073021651 regulatory binding site [polypeptide binding]; other site 1278073021652 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 1278073021653 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1278073021654 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1278073021655 GAF domain; Region: GAF; pfam01590 1278073021656 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1278073021657 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1278073021658 putative active site [active] 1278073021659 heme pocket [chemical binding]; other site 1278073021660 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073021661 dimer interface [polypeptide binding]; other site 1278073021662 phosphorylation site [posttranslational modification] 1278073021663 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073021664 ATP binding site [chemical binding]; other site 1278073021665 Mg2+ binding site [ion binding]; other site 1278073021666 G-X-G motif; other site 1278073021667 dipeptidase PepV; Reviewed; Region: PRK07318 1278073021668 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1278073021669 metal binding site [ion binding]; metal-binding site 1278073021670 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1278073021671 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1278073021672 hypothetical protein; Provisional; Region: PRK12378 1278073021673 Protein of unknown function (DUF962); Region: DUF962; pfam06127 1278073021674 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073021675 S-adenosylmethionine binding site [chemical binding]; other site 1278073021676 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1278073021677 active site 1278073021678 Cupin domain; Region: Cupin_2; cl17218 1278073021679 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1278073021680 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 1278073021681 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1278073021682 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1278073021683 FtsX-like permease family; Region: FtsX; pfam02687 1278073021684 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1278073021685 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1278073021686 DNA-binding site [nucleotide binding]; DNA binding site 1278073021687 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1278073021688 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1278073021689 homodimer interface [polypeptide binding]; other site 1278073021690 catalytic residue [active] 1278073021691 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 1278073021692 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 1278073021693 Predicted lipoprotein of unknown function (DUF2380); Region: DUF2380; cl15289 1278073021694 Protein of unknown function (Gmx_para_CXXCG); Region: Gmx_para_CXXCG; cl15282 1278073021695 methionine aminopeptidase; Provisional; Region: PRK12318 1278073021696 SEC-C motif; Region: SEC-C; pfam02810 1278073021697 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1278073021698 active site 1278073021699 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1278073021700 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1278073021701 Coenzyme A binding pocket [chemical binding]; other site 1278073021702 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1278073021703 5' nucleotidase family; Region: 5_nucleotid; pfam05761 1278073021704 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 1278073021705 DNA gyrase, B subunit; Region: gyrB; TIGR01059 1278073021706 DNA gyrase B; Region: DNA_gyraseB; pfam00204 1278073021707 ATP binding site [chemical binding]; other site 1278073021708 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 1278073021709 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1278073021710 active site 1278073021711 substrate binding sites [chemical binding]; other site 1278073021712 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1278073021713 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1278073021714 non-specific DNA binding site [nucleotide binding]; other site 1278073021715 salt bridge; other site 1278073021716 sequence-specific DNA binding site [nucleotide binding]; other site 1278073021717 HD domain; Region: HD_3; pfam13023 1278073021718 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1278073021719 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1278073021720 Coenzyme A binding pocket [chemical binding]; other site 1278073021721 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1278073021722 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1278073021723 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 1278073021724 Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin; Region: M3A_TOP; cd06455 1278073021725 active site 1278073021726 Zn binding site [ion binding]; other site 1278073021727 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 1278073021728 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073021729 Walker A motif; other site 1278073021730 ATP binding site [chemical binding]; other site 1278073021731 Walker B motif; other site 1278073021732 R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich...; Region: R3H; cl00297 1278073021733 RxxxH motif; other site 1278073021734 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 1278073021735 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 1278073021736 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 1278073021737 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 1278073021738 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 1278073021739 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 1278073021740 SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133 1278073021741 SCP_PR-1_like: SCP-like extracellular protein domain, PR-1 like subfamily. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal...; Region: SCP_PR-1_like; cd05381 1278073021742 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1278073021743 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1278073021744 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1278073021745 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1278073021746 parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805 1278073021747 conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806 1278073021748 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 1278073021749 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1278073021750 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1278073021751 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1278073021752 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1278073021753 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1278073021754 dimer interface [polypeptide binding]; other site 1278073021755 conserved gate region; other site 1278073021756 putative PBP binding loops; other site 1278073021757 ABC-ATPase subunit interface; other site 1278073021758 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1278073021759 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073021760 Walker A/P-loop; other site 1278073021761 ATP binding site [chemical binding]; other site 1278073021762 Q-loop/lid; other site 1278073021763 ABC transporter signature motif; other site 1278073021764 Walker B; other site 1278073021765 D-loop; other site 1278073021766 H-loop/switch region; other site 1278073021767 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1278073021768 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_14; cd13139 1278073021769 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1278073021770 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1278073021771 putative trimer interface [polypeptide binding]; other site 1278073021772 putative CoA binding site [chemical binding]; other site 1278073021773 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1278073021774 putative trimer interface [polypeptide binding]; other site 1278073021775 putative CoA binding site [chemical binding]; other site 1278073021776 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1278073021777 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1278073021778 substrate binding site [chemical binding]; other site 1278073021779 activation loop (A-loop); other site 1278073021780 Predicted ATPase [General function prediction only]; Region: COG3899 1278073021781 AAA ATPase domain; Region: AAA_16; pfam13191 1278073021782 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1278073021783 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1278073021784 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1278073021785 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1278073021786 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073021787 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073021788 dimer interface [polypeptide binding]; other site 1278073021789 phosphorylation site [posttranslational modification] 1278073021790 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073021791 ATP binding site [chemical binding]; other site 1278073021792 Mg2+ binding site [ion binding]; other site 1278073021793 G-X-G motif; other site 1278073021794 asparaginyl-tRNA synthetase; Region: PLN02221 1278073021795 Competence-damaged protein; Region: CinA; pfam02464 1278073021796 GRAS family transcription factor; Region: GRAS; pfam03514 1278073021797 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1278073021798 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1278073021799 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1278073021800 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1278073021801 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1278073021802 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1278073021803 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1278073021804 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1278073021805 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1278073021806 Beta-lactamase; Region: Beta-lactamase; pfam00144 1278073021807 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1278073021808 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1278073021809 TPR motif; other site 1278073021810 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1278073021811 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 1278073021812 dimer interface [polypeptide binding]; other site 1278073021813 phosphorylation site [posttranslational modification] 1278073021814 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073021815 ATP binding site [chemical binding]; other site 1278073021816 Mg2+ binding site [ion binding]; other site 1278073021817 G-X-G motif; other site 1278073021818 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1278073021819 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073021820 active site 1278073021821 phosphorylation site [posttranslational modification] 1278073021822 intermolecular recognition site; other site 1278073021823 dimerization interface [polypeptide binding]; other site 1278073021824 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073021825 Walker A motif; other site 1278073021826 ATP binding site [chemical binding]; other site 1278073021827 Walker B motif; other site 1278073021828 arginine finger; other site 1278073021829 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1278073021830 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 1278073021831 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1278073021832 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1278073021833 FtsX-like permease family; Region: FtsX; pfam02687 1278073021834 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1278073021835 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1278073021836 Walker A/P-loop; other site 1278073021837 ATP binding site [chemical binding]; other site 1278073021838 Q-loop/lid; other site 1278073021839 ABC transporter signature motif; other site 1278073021840 Walker B; other site 1278073021841 D-loop; other site 1278073021842 H-loop/switch region; other site 1278073021843 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 1278073021844 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1278073021845 FtsX-like permease family; Region: FtsX; pfam02687 1278073021846 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1278073021847 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 1278073021848 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1278073021849 FtsX-like permease family; Region: FtsX; pfam02687 1278073021850 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1278073021851 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 1278073021852 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1278073021853 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1278073021854 FtsX-like permease family; Region: FtsX; pfam02687 1278073021855 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 1278073021856 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1278073021857 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1278073021858 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1278073021859 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1278073021860 Walker A/P-loop; other site 1278073021861 ATP binding site [chemical binding]; other site 1278073021862 Q-loop/lid; other site 1278073021863 ABC transporter signature motif; other site 1278073021864 Walker B; other site 1278073021865 D-loop; other site 1278073021866 H-loop/switch region; other site 1278073021867 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1278073021868 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1278073021869 HlyD family secretion protein; Region: HlyD_3; pfam13437 1278073021870 malonyl-CoA synthase; Validated; Region: PRK07514 1278073021871 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1278073021872 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1278073021873 acyl-activating enzyme (AAE) consensus motif; other site 1278073021874 AMP binding site [chemical binding]; other site 1278073021875 active site 1278073021876 CoA binding site [chemical binding]; other site 1278073021877 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073021878 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073021879 active site 1278073021880 phosphorylation site [posttranslational modification] 1278073021881 intermolecular recognition site; other site 1278073021882 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1278073021883 catalytic site [active] 1278073021884 putative active site [active] 1278073021885 putative substrate binding site [chemical binding]; other site 1278073021886 dimer interface [polypeptide binding]; other site 1278073021887 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1278073021888 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1278073021889 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 1278073021890 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1278073021891 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1278073021892 active site 1278073021893 enoyl-CoA hydratase; Provisional; Region: PRK06688 1278073021894 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1278073021895 substrate binding site [chemical binding]; other site 1278073021896 oxyanion hole (OAH) forming residues; other site 1278073021897 trimer interface [polypeptide binding]; other site 1278073021898 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 1278073021899 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 1278073021900 Zn binding site [ion binding]; other site 1278073021901 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1278073021902 putative acyl-acceptor binding pocket; other site 1278073021903 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 1278073021904 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1278073021905 active site 1278073021906 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1278073021907 dimer interface [polypeptide binding]; other site 1278073021908 substrate binding site [chemical binding]; other site 1278073021909 catalytic residues [active] 1278073021910 RNA polymerase sigma-70 factor, Myxococcales family 1; Region: Sig-70_gmx1; TIGR03001 1278073021911 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1278073021912 DNA binding residues [nucleotide binding] 1278073021913 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 1278073021914 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 1278073021915 active site 1278073021916 metal binding site [ion binding]; metal-binding site 1278073021917 conserved hypothetical protein; Region: TIGR02270 1278073021918 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 1278073021919 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 1278073021920 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1278073021921 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1278073021922 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 1278073021923 Arrestin (or S-antigen), N-terminal domain; Region: Arrestin_N; pfam00339 1278073021924 HEAT repeats; Region: HEAT_2; pfam13646 1278073021925 Arylesterase; Region: Arylesterase; pfam01731 1278073021926 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1278073021927 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1278073021928 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1278073021929 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1278073021930 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1278073021931 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1278073021932 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1278073021933 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1278073021934 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1278073021935 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1278073021936 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1278073021937 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1278073021938 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1278073021939 FOG: Ankyrin repeat [General function prediction only]; Region: Arp; COG0666 1278073021940 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1278073021941 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1278073021942 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1278073021943 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1278073021944 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1278073021945 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1278073021946 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1278073021947 Ligand Binding Site [chemical binding]; other site 1278073021948 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1278073021949 Ligand Binding Site [chemical binding]; other site 1278073021950 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1278073021951 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 1278073021952 putative ligand binding site [chemical binding]; other site 1278073021953 putative NAD binding site [chemical binding]; other site 1278073021954 catalytic site [active] 1278073021955 thioredoxin 2; Provisional; Region: PRK10996 1278073021956 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1278073021957 catalytic residues [active] 1278073021958 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1278073021959 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1278073021960 active site 1278073021961 LysR family transcriptional regulator; Provisional; Region: PRK14997 1278073021962 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1278073021963 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1278073021964 putative effector binding pocket; other site 1278073021965 dimerization interface [polypeptide binding]; other site 1278073021966 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1278073021967 Kelch motif; Region: Kelch_1; pfam01344 1278073021968 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1278073021969 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1278073021970 UPF0126 domain; Region: UPF0126; pfam03458 1278073021971 Predicted membrane protein [Function unknown]; Region: COG2860 1278073021972 UPF0126 domain; Region: UPF0126; pfam03458 1278073021973 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1278073021974 Yip1 domain; Region: Yip1; pfam04893 1278073021975 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1278073021976 Beta-lactamase; Region: Beta-lactamase; pfam00144 1278073021977 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1278073021978 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1278073021979 active site 1278073021980 oxyanion hole [active] 1278073021981 catalytic triad [active] 1278073021982 MarR family; Region: MarR; pfam01047 1278073021983 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1278073021984 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1278073021985 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1278073021986 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1278073021987 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1278073021988 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1278073021989 dimerization interface [polypeptide binding]; other site 1278073021990 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; pfam09995 1278073021991 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 1278073021992 ADP-ribose binding site [chemical binding]; other site 1278073021993 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 1278073021994 Pirin-related protein [General function prediction only]; Region: COG1741 1278073021995 Pirin; Region: Pirin; pfam02678 1278073021996 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1278073021997 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1278073021998 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1278073021999 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1278073022000 substrate binding pocket [chemical binding]; other site 1278073022001 dimerization interface [polypeptide binding]; other site 1278073022002 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073022003 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1278073022004 dimerization interface [polypeptide binding]; other site 1278073022005 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073022006 dimer interface [polypeptide binding]; other site 1278073022007 phosphorylation site [posttranslational modification] 1278073022008 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073022009 ATP binding site [chemical binding]; other site 1278073022010 Mg2+ binding site [ion binding]; other site 1278073022011 G-X-G motif; other site 1278073022012 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 1278073022013 Predicted membrane protein [Function unknown]; Region: COG3768 1278073022014 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1278073022015 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1278073022016 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 1278073022017 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1278073022018 CARDB; Region: CARDB; pfam07705 1278073022019 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1278073022020 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1278073022021 catalytic triad [active] 1278073022022 conserved cis-peptide bond; other site 1278073022023 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 1278073022024 Protein phosphatase 2C; Region: PP2C_2; pfam13672 1278073022025 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1278073022026 nudix motif; other site 1278073022027 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1278073022028 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1278073022029 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1278073022030 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 1278073022031 putative NAD(P) binding site [chemical binding]; other site 1278073022032 active site 1278073022033 PEGA domain; Region: PEGA; pfam08308 1278073022034 IgA Peptidase M64; Region: Peptidase_M64; pfam09471 1278073022035 Bacterial Ig-like domain; Region: Big_5; pfam13205 1278073022036 Protein of unknown function (DUF4019); Region: DUF4019; pfam13211 1278073022037 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1278073022038 putative catalytic site [active] 1278073022039 putative metal binding site [ion binding]; other site 1278073022040 putative phosphate binding site [ion binding]; other site 1278073022041 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 1278073022042 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 1278073022043 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1278073022044 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073022045 NAD(P) binding site [chemical binding]; other site 1278073022046 active site 1278073022047 short chain dehydrogenase; Provisional; Region: PRK07454 1278073022048 classical (c) SDRs; Region: SDR_c; cd05233 1278073022049 NAD(P) binding site [chemical binding]; other site 1278073022050 active site 1278073022051 Astacin (Peptidase family M12A); Region: Astacin; pfam01400 1278073022052 Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to...; Region: ZnMc_astacin_like; cd04280 1278073022053 active site 1278073022054 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1278073022055 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1278073022056 Hemerythrin-like domain; Region: Hr-like; cd12108 1278073022057 Fe binding site [ion binding]; other site 1278073022058 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1278073022059 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1278073022060 FMN-binding pocket [chemical binding]; other site 1278073022061 flavin binding motif; other site 1278073022062 phosphate binding motif [ion binding]; other site 1278073022063 beta-alpha-beta structure motif; other site 1278073022064 NAD binding pocket [chemical binding]; other site 1278073022065 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1278073022066 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1278073022067 catalytic loop [active] 1278073022068 iron binding site [ion binding]; other site 1278073022069 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 1278073022070 Two component regulator propeller; Region: Reg_prop; pfam07494 1278073022071 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 1278073022072 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073022073 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073022074 dimer interface [polypeptide binding]; other site 1278073022075 phosphorylation site [posttranslational modification] 1278073022076 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073022077 ATP binding site [chemical binding]; other site 1278073022078 Mg2+ binding site [ion binding]; other site 1278073022079 G-X-G motif; other site 1278073022080 Herpesvirus large structural phosphoprotein UL32; Region: Herpes_UL32; pfam06070 1278073022081 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073022082 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073022083 active site 1278073022084 phosphorylation site [posttranslational modification] 1278073022085 intermolecular recognition site; other site 1278073022086 dimerization interface [polypeptide binding]; other site 1278073022087 Protein kinase domain; Region: Pkinase; pfam00069 1278073022088 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073022089 active site 1278073022090 ATP binding site [chemical binding]; other site 1278073022091 substrate binding site [chemical binding]; other site 1278073022092 activation loop (A-loop); other site 1278073022093 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1278073022094 active site 1278073022095 catalytic residues [active] 1278073022096 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538 1278073022097 Subtilase family; Region: Peptidase_S8; pfam00082 1278073022098 catalytic residues [active] 1278073022099 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 1278073022100 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 1278073022101 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 1278073022102 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1278073022103 active site 1278073022104 Kelch domain; Region: Kelch; smart00612 1278073022105 Kelch domain; Region: Kelch; smart00612 1278073022106 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1278073022107 Kelch motif; Region: Kelch_1; pfam01344 1278073022108 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1278073022109 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1278073022110 Kelch motif; Region: Kelch_1; pfam01344 1278073022111 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1278073022112 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 1278073022113 putative deacylase active site [active] 1278073022114 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1278073022115 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1278073022116 Walker A/P-loop; other site 1278073022117 ATP binding site [chemical binding]; other site 1278073022118 Q-loop/lid; other site 1278073022119 ABC transporter signature motif; other site 1278073022120 Walker B; other site 1278073022121 D-loop; other site 1278073022122 H-loop/switch region; other site 1278073022123 TOBE domain; Region: TOBE_2; pfam08402 1278073022124 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1278073022125 metal-binding site [ion binding] 1278073022126 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1278073022127 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073022128 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1278073022129 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1278073022130 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1278073022131 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1278073022132 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1278073022133 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1278073022134 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1278073022135 Predicted transcriptional regulators [Transcription]; Region: COG1695 1278073022136 transcriptional regulator, Acidobacterial, PadR-family; Region: padR_acidobact; TIGR03433 1278073022137 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 1278073022138 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1278073022139 FtsX-like permease family; Region: FtsX; pfam02687 1278073022140 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1278073022141 FtsX-like permease family; Region: FtsX; pfam02687 1278073022142 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1278073022143 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1278073022144 metal-binding site [ion binding] 1278073022145 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1278073022146 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1278073022147 active site 1278073022148 motif I; other site 1278073022149 motif II; other site 1278073022150 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 1278073022151 Dienelactone hydrolase family; Region: DLH; pfam01738 1278073022152 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1278073022153 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1278073022154 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1278073022155 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1278073022156 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1278073022157 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1278073022158 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1278073022159 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1278073022160 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1278073022161 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1278073022162 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1278073022163 Walker A/P-loop; other site 1278073022164 ATP binding site [chemical binding]; other site 1278073022165 Q-loop/lid; other site 1278073022166 ABC transporter signature motif; other site 1278073022167 Walker B; other site 1278073022168 D-loop; other site 1278073022169 H-loop/switch region; other site 1278073022170 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 1278073022171 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1278073022172 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1278073022173 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1278073022174 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1278073022175 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1278073022176 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 1278073022177 Protein of unknown function (Gmx_para_CXXCG); Region: Gmx_para_CXXCG; cl15282 1278073022178 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1278073022179 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1278073022180 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1278073022181 active site 1278073022182 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 1278073022183 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1278073022184 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1278073022185 dimerization interface [polypeptide binding]; other site 1278073022186 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 1278073022187 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1278073022188 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1278073022189 HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236 1278073022190 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1278073022191 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1278073022192 putative NAD(P) binding site [chemical binding]; other site 1278073022193 TIGR02646 family protein; Region: TIGR02646 1278073022194 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073022195 AAA domain; Region: AAA_23; pfam13476 1278073022196 AAA domain; Region: AAA_21; pfam13304 1278073022197 Walker A/P-loop; other site 1278073022198 ATP binding site [chemical binding]; other site 1278073022199 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073022200 Walker B; other site 1278073022201 D-loop; other site 1278073022202 H-loop/switch region; other site 1278073022203 MoxR-like ATPases [General function prediction only]; Region: COG0714 1278073022204 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 1278073022205 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 1278073022206 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 1278073022207 metal ion-dependent adhesion site (MIDAS); other site 1278073022208 SWIM zinc finger; Region: SWIM; pfam04434 1278073022209 HEAT repeats; Region: HEAT_2; pfam13646 1278073022210 HEAT repeats; Region: HEAT_2; pfam13646 1278073022211 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1278073022212 Beta-lactamase; Region: Beta-lactamase; pfam00144 1278073022213 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1278073022214 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1278073022215 TAP-like protein; Region: Abhydrolase_4; pfam08386 1278073022216 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073022217 Walker A/P-loop; other site 1278073022218 ATP binding site [chemical binding]; other site 1278073022219 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 1278073022220 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 1278073022221 HEAT repeats; Region: HEAT_2; pfam13646 1278073022222 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073022223 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1278073022224 TPR motif; other site 1278073022225 binding surface 1278073022226 Outer membrane efflux protein; Region: OEP; pfam02321 1278073022227 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1278073022228 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1278073022229 HlyD family secretion protein; Region: HlyD_3; pfam13437 1278073022230 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1278073022231 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1278073022232 ligand binding site [chemical binding]; other site 1278073022233 flexible hinge region; other site 1278073022234 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1278073022235 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 1278073022236 active site 1278073022237 nucleophile elbow; other site 1278073022238 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 1278073022239 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1278073022240 active site 1278073022241 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 1278073022242 putative acyl-acceptor binding pocket; other site 1278073022243 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073022244 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1278073022245 NAD(P) binding site [chemical binding]; other site 1278073022246 active site 1278073022247 Trm112p-like protein; Region: Trm112p; pfam03966 1278073022248 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1278073022249 S-adenosylmethionine binding site [chemical binding]; other site 1278073022250 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073022251 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073022252 active site 1278073022253 ATP binding site [chemical binding]; other site 1278073022254 substrate binding site [chemical binding]; other site 1278073022255 activation loop (A-loop); other site 1278073022256 AAA ATPase domain; Region: AAA_16; pfam13191 1278073022257 Predicted ATPase [General function prediction only]; Region: COG3899 1278073022258 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1278073022259 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 1278073022260 Myxococcales-restricted protein, TIGR02265 family; Region: Mxa_TIGR02265 1278073022261 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1278073022262 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1278073022263 NAD(P) binding site [chemical binding]; other site 1278073022264 active site 1278073022265 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1278073022266 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1278073022267 amidase catalytic site [active] 1278073022268 Zn binding residues [ion binding]; other site 1278073022269 substrate binding site [chemical binding]; other site 1278073022270 Predicted esterase [General function prediction only]; Region: COG0400 1278073022271 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1278073022272 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1278073022273 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1278073022274 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1278073022275 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 1278073022276 putative NAD(P) binding site [chemical binding]; other site 1278073022277 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1278073022278 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1278073022279 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1278073022280 Transposase domain (DUF772); Region: DUF772; pfam05598 1278073022281 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 1278073022282 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1278073022283 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 1278073022284 CRISPR-associated protein Cas5, N-terminal domain; Region: CRISPR_cas5; TIGR02593 1278073022285 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1278073022286 CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875 1278073022287 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cl00803 1278073022288 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1278073022289 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 1278073022290 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1278073022291 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl09782 1278073022292 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 1278073022293 CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cd09749 1278073022294 CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440 1278073022295 CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700 1278073022296 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075 1278073022297 CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577 1278073022298 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09679 1278073022299 CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436 1278073022300 Uncharacterized conserved protein [Function unknown]; Region: COG4279 1278073022301 SWIM zinc finger; Region: SWIM; pfam04434 1278073022302 SNF2 Helicase protein; Region: DUF3670; pfam12419 1278073022303 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1278073022304 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1278073022305 ATP binding site [chemical binding]; other site 1278073022306 putative Mg++ binding site [ion binding]; other site 1278073022307 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1278073022308 nucleotide binding region [chemical binding]; other site 1278073022309 ATP-binding site [chemical binding]; other site 1278073022310 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 1278073022311 active site 1278073022312 NTP binding site [chemical binding]; other site 1278073022313 metal binding triad [ion binding]; metal-binding site 1278073022314 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073022315 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073022316 active site 1278073022317 ATP binding site [chemical binding]; other site 1278073022318 substrate binding site [chemical binding]; other site 1278073022319 activation loop (A-loop); other site 1278073022320 RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984 1278073022321 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073022322 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1278073022323 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073022324 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073022325 active site 1278073022326 ATP binding site [chemical binding]; other site 1278073022327 substrate binding site [chemical binding]; other site 1278073022328 activation loop (A-loop); other site 1278073022329 AAA ATPase domain; Region: AAA_16; pfam13191 1278073022330 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1278073022331 binding surface 1278073022332 TPR motif; other site 1278073022333 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1278073022334 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1278073022335 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1278073022336 dimer interface [polypeptide binding]; other site 1278073022337 conserved gate region; other site 1278073022338 putative PBP binding loops; other site 1278073022339 ABC-ATPase subunit interface; other site 1278073022340 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1278073022341 dimer interface [polypeptide binding]; other site 1278073022342 conserved gate region; other site 1278073022343 putative PBP binding loops; other site 1278073022344 ABC-ATPase subunit interface; other site 1278073022345 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1278073022346 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1278073022347 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1278073022348 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14954 1278073022349 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1278073022350 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1278073022351 putative di-iron ligands [ion binding]; other site 1278073022352 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 1278073022353 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1278073022354 MltA specific insert domain; Region: MltA; smart00925 1278073022355 3D domain; Region: 3D; pfam06725 1278073022356 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1278073022357 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1278073022358 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1278073022359 active site 1278073022360 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 1278073022361 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 1278073022362 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 1278073022363 active site flap/lid [active] 1278073022364 nucleophilic elbow; other site 1278073022365 catalytic triad [active] 1278073022366 short chain dehydrogenase; Provisional; Region: PRK08278 1278073022367 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 1278073022368 NAD(P) binding site [chemical binding]; other site 1278073022369 homodimer interface [polypeptide binding]; other site 1278073022370 active site 1278073022371 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1278073022372 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1278073022373 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1278073022374 dimerization interface [polypeptide binding]; other site 1278073022375 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1278073022376 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 1278073022377 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1278073022378 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1278073022379 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1278073022380 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1278073022381 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1278073022382 LOW PSII ACCUMULATION1; Provisional; Region: LPA1; PLN03098 1278073022383 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 1278073022384 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1278073022385 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1278073022386 catalytic residue [active] 1278073022387 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 1278073022388 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1278073022389 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 1278073022390 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1278073022391 Bacterial transcriptional activator domain; Region: BTAD; smart01043 1278073022392 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1278073022393 TPR motif; other site 1278073022394 AAA ATPase domain; Region: AAA_16; pfam13191 1278073022395 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1278073022396 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1278073022397 putative effector binding pocket; other site 1278073022398 putative dimerization interface [polypeptide binding]; other site 1278073022399 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1278073022400 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1278073022401 putative NAD(P) binding site [chemical binding]; other site 1278073022402 putative substrate binding site [chemical binding]; other site 1278073022403 catalytic Zn binding site [ion binding]; other site 1278073022404 structural Zn binding site [ion binding]; other site 1278073022405 dimer interface [polypeptide binding]; other site 1278073022406 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1278073022407 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1278073022408 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1278073022409 active site 1278073022410 catalytic residues [active] 1278073022411 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538 1278073022412 PA/protease or protease-like domain interface [polypeptide binding]; other site 1278073022413 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1278073022414 catalytic residues [active] 1278073022415 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1278073022416 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 1278073022417 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1278073022418 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1278073022419 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1278073022420 PAS fold; Region: PAS; pfam00989 1278073022421 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1278073022422 putative active site [active] 1278073022423 heme pocket [chemical binding]; other site 1278073022424 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1278073022425 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073022426 dimer interface [polypeptide binding]; other site 1278073022427 phosphorylation site [posttranslational modification] 1278073022428 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073022429 ATP binding site [chemical binding]; other site 1278073022430 Mg2+ binding site [ion binding]; other site 1278073022431 G-X-G motif; other site 1278073022432 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 1278073022433 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073022434 binding surface 1278073022435 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1278073022436 TPR motif; other site 1278073022437 SlyX; Region: SlyX; pfam04102 1278073022438 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1278073022439 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1278073022440 NADP binding site [chemical binding]; other site 1278073022441 dimer interface [polypeptide binding]; other site 1278073022442 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1278073022443 active site 1278073022444 catalytic residues [active] 1278073022445 metal binding site [ion binding]; metal-binding site 1278073022446 SnoaL-like domain; Region: SnoaL_2; pfam12680 1278073022447 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1278073022448 MarR family; Region: MarR_2; pfam12802 1278073022449 Protein of unknown function (DUF2378); Region: DUF2378; pfam09536 1278073022450 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 1278073022451 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1278073022452 active site 1278073022453 MASE1; Region: MASE1; pfam05231 1278073022454 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073022455 dimer interface [polypeptide binding]; other site 1278073022456 phosphorylation site [posttranslational modification] 1278073022457 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073022458 ATP binding site [chemical binding]; other site 1278073022459 Mg2+ binding site [ion binding]; other site 1278073022460 G-X-G motif; other site 1278073022461 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1278073022462 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073022463 Walker A motif; other site 1278073022464 ATP binding site [chemical binding]; other site 1278073022465 Walker B motif; other site 1278073022466 arginine finger; other site 1278073022467 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 1278073022468 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1278073022469 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1278073022470 TPP-binding site [chemical binding]; other site 1278073022471 dimer interface [polypeptide binding]; other site 1278073022472 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1278073022473 PYR/PP interface [polypeptide binding]; other site 1278073022474 dimer interface [polypeptide binding]; other site 1278073022475 TPP binding site [chemical binding]; other site 1278073022476 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1278073022477 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 1278073022478 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1278073022479 RNA binding site [nucleotide binding]; other site 1278073022480 active site 1278073022481 Predicted ATPase [General function prediction only]; Region: COG4637 1278073022482 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073022483 Walker A/P-loop; other site 1278073022484 ATP binding site [chemical binding]; other site 1278073022485 PS-10 peptidase S37; Region: Peptidase_S37; pfam05576 1278073022486 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 1278073022487 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1278073022488 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1278073022489 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1278073022490 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1278073022491 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1278073022492 dimerization interface [polypeptide binding]; other site 1278073022493 substrate binding pocket [chemical binding]; other site 1278073022494 Cupin domain; Region: Cupin_2; cl17218 1278073022495 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1278073022496 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1278073022497 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1278073022498 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1278073022499 LVIVD repeat; Region: LVIVD; pfam08309 1278073022500 Uncharacterized conserved protein [Function unknown]; Region: COG5276 1278073022501 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073022502 AAA domain; Region: AAA_21; pfam13304 1278073022503 Walker A/P-loop; other site 1278073022504 ATP binding site [chemical binding]; other site 1278073022505 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1278073022506 ABC transporter signature motif; other site 1278073022507 Walker B; other site 1278073022508 D-loop; other site 1278073022509 H-loop/switch region; other site 1278073022510 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073022511 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073022512 active site 1278073022513 phosphorylation site [posttranslational modification] 1278073022514 intermolecular recognition site; other site 1278073022515 dimerization interface [polypeptide binding]; other site 1278073022516 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 1278073022517 putative binding surface; other site 1278073022518 active site 1278073022519 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073022520 active site 1278073022521 phosphorylation site [posttranslational modification] 1278073022522 intermolecular recognition site; other site 1278073022523 dimerization interface [polypeptide binding]; other site 1278073022524 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073022525 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073022526 active site 1278073022527 phosphorylation site [posttranslational modification] 1278073022528 intermolecular recognition site; other site 1278073022529 dimerization interface [polypeptide binding]; other site 1278073022530 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1278073022531 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1278073022532 metal binding site [ion binding]; metal-binding site 1278073022533 active site 1278073022534 I-site; other site 1278073022535 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1278073022536 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1278073022537 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1278073022538 putative active site [active] 1278073022539 heme pocket [chemical binding]; other site 1278073022540 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073022541 phosphorylation site [posttranslational modification] 1278073022542 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073022543 ATP binding site [chemical binding]; other site 1278073022544 Mg2+ binding site [ion binding]; other site 1278073022545 G-X-G motif; other site 1278073022546 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073022547 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073022548 active site 1278073022549 phosphorylation site [posttranslational modification] 1278073022550 intermolecular recognition site; other site 1278073022551 dimerization interface [polypeptide binding]; other site 1278073022552 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073022553 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073022554 active site 1278073022555 phosphorylation site [posttranslational modification] 1278073022556 intermolecular recognition site; other site 1278073022557 dimerization interface [polypeptide binding]; other site 1278073022558 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073022559 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073022560 active site 1278073022561 phosphorylation site [posttranslational modification] 1278073022562 intermolecular recognition site; other site 1278073022563 dimerization interface [polypeptide binding]; other site 1278073022564 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1278073022565 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1278073022566 non-specific DNA binding site [nucleotide binding]; other site 1278073022567 salt bridge; other site 1278073022568 sequence-specific DNA binding site [nucleotide binding]; other site 1278073022569 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1278073022570 non-specific DNA binding site [nucleotide binding]; other site 1278073022571 salt bridge; other site 1278073022572 sequence-specific DNA binding site [nucleotide binding]; other site 1278073022573 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073022574 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073022575 active site 1278073022576 ATP binding site [chemical binding]; other site 1278073022577 substrate binding site [chemical binding]; other site 1278073022578 activation loop (A-loop); other site 1278073022579 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073022580 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073022581 active site 1278073022582 ATP binding site [chemical binding]; other site 1278073022583 substrate binding site [chemical binding]; other site 1278073022584 activation loop (A-loop); other site 1278073022585 FOG: CBS domain [General function prediction only]; Region: COG0517 1278073022586 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1278073022587 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1278073022588 Kelch domain; Region: Kelch; smart00612 1278073022589 Kelch motif; Region: Kelch_6; pfam13964 1278073022590 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1278073022591 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1278073022592 iron-sulfur cluster [ion binding]; other site 1278073022593 [2Fe-2S] cluster binding site [ion binding]; other site 1278073022594 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1278073022595 iron-sulfur cluster [ion binding]; other site 1278073022596 [2Fe-2S] cluster binding site [ion binding]; other site 1278073022597 YceI-like domain; Region: YceI; pfam04264 1278073022598 GAF domain; Region: GAF; cl17456 1278073022599 GAF domain; Region: GAF_2; pfam13185 1278073022600 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1278073022601 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1278073022602 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073022603 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073022604 dimer interface [polypeptide binding]; other site 1278073022605 phosphorylation site [posttranslational modification] 1278073022606 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073022607 ATP binding site [chemical binding]; other site 1278073022608 Mg2+ binding site [ion binding]; other site 1278073022609 G-X-G motif; other site 1278073022610 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1278073022611 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1278073022612 Cu(I) binding site [ion binding]; other site 1278073022613 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1278073022614 putative ADP-ribose binding site [chemical binding]; other site 1278073022615 putative active site [active] 1278073022616 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1278073022617 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1278073022618 Ligand Binding Site [chemical binding]; other site 1278073022619 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1278073022620 Ligand Binding Site [chemical binding]; other site 1278073022621 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1278073022622 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073022623 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073022624 active site 1278073022625 phosphorylation site [posttranslational modification] 1278073022626 intermolecular recognition site; other site 1278073022627 dimerization interface [polypeptide binding]; other site 1278073022628 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1278073022629 cyclase homology domain; Region: CHD; cd07302 1278073022630 nucleotidyl binding site; other site 1278073022631 metal binding site [ion binding]; metal-binding site 1278073022632 dimer interface [polypeptide binding]; other site 1278073022633 GAF domain; Region: GAF; pfam01590 1278073022634 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1278073022635 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073022636 dimer interface [polypeptide binding]; other site 1278073022637 phosphorylation site [posttranslational modification] 1278073022638 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073022639 ATP binding site [chemical binding]; other site 1278073022640 Mg2+ binding site [ion binding]; other site 1278073022641 G-X-G motif; other site 1278073022642 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 1278073022643 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 1278073022644 Proline dehydrogenase; Region: Pro_dh; cl03282 1278073022645 Myxococcales-restricted protein, TIGR02265 family; Region: Mxa_TIGR02265 1278073022646 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1278073022647 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1278073022648 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1278073022649 GTP binding site; other site 1278073022650 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1278073022651 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1278073022652 dimer interface [polypeptide binding]; other site 1278073022653 putative functional site; other site 1278073022654 putative MPT binding site; other site 1278073022655 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1278073022656 Walker A motif; other site 1278073022657 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 1278073022658 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1278073022659 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1278073022660 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1278073022661 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1278073022662 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1278073022663 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 1278073022664 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073022665 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073022666 active site 1278073022667 phosphorylation site [posttranslational modification] 1278073022668 intermolecular recognition site; other site 1278073022669 dimerization interface [polypeptide binding]; other site 1278073022670 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 1278073022671 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1278073022672 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 1278073022673 DXD motif; other site 1278073022674 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1278073022675 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1278073022676 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1278073022677 O-Antigen ligase; Region: Wzy_C; pfam04932 1278073022678 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073022679 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073022680 active site 1278073022681 phosphorylation site [posttranslational modification] 1278073022682 intermolecular recognition site; other site 1278073022683 dimerization interface [polypeptide binding]; other site 1278073022684 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1278073022685 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1278073022686 putative active site [active] 1278073022687 heme pocket [chemical binding]; other site 1278073022688 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1278073022689 dimer interface [polypeptide binding]; other site 1278073022690 phosphorylation site [posttranslational modification] 1278073022691 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1278073022692 ATP binding site [chemical binding]; other site 1278073022693 Mg2+ binding site [ion binding]; other site 1278073022694 G-X-G motif; other site 1278073022695 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 1278073022696 putative ADP-binding pocket [chemical binding]; other site 1278073022697 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1278073022698 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1278073022699 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1278073022700 active site 1278073022701 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 1278073022702 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1278073022703 trimer interface [polypeptide binding]; other site 1278073022704 active site 1278073022705 substrate binding site [chemical binding]; other site 1278073022706 CoA binding site [chemical binding]; other site 1278073022707 Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891 1278073022708 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 1278073022709 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1278073022710 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1278073022711 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073022712 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1278073022713 active site 1278073022714 ATP binding site [chemical binding]; other site 1278073022715 substrate binding site [chemical binding]; other site 1278073022716 activation loop (A-loop); other site 1278073022717 Beta-lactamase; Region: Beta-lactamase; pfam00144 1278073022718 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1278073022719 TPR repeat; Region: TPR_11; pfam13414 1278073022720 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073022721 binding surface 1278073022722 TPR motif; other site 1278073022723 Beta-lactamase; Region: Beta-lactamase; pfam00144 1278073022724 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1278073022725 TPR repeat; Region: TPR_11; pfam13414 1278073022726 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073022727 binding surface 1278073022728 TPR motif; other site 1278073022729 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 1278073022730 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1278073022731 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1278073022732 YCII-related domain; Region: YCII; cl00999 1278073022733 FAD binding domain; Region: FAD_binding_4; pfam01565 1278073022734 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1278073022735 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 1278073022736 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1278073022737 conserved cys residue [active] 1278073022738 Histone methylation protein DOT1; Region: DOT1; pfam08123 1278073022739 seryl-tRNA synthetase; Provisional; Region: PRK05431 1278073022740 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1278073022741 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1278073022742 Walker A motif; other site 1278073022743 ATP binding site [chemical binding]; other site 1278073022744 Walker B motif; other site 1278073022745 arginine finger; other site 1278073022746 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073022747 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073022748 active site 1278073022749 ATP binding site [chemical binding]; other site 1278073022750 substrate binding site [chemical binding]; other site 1278073022751 activation loop (A-loop); other site 1278073022752 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073022753 TPR motif; other site 1278073022754 binding surface 1278073022755 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073022756 binding surface 1278073022757 TPR motif; other site 1278073022758 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1278073022759 TPR motif; other site 1278073022760 binding surface 1278073022761 TPR repeat; Region: TPR_11; pfam13414 1278073022762 TPR repeat; Region: TPR_11; pfam13414 1278073022763 alanine dehydrogenase; Validated; Region: PRK06046 1278073022764 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1278073022765 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 1278073022766 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1278073022767 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1278073022768 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1278073022769 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1278073022770 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1278073022771 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1278073022772 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1278073022773 Cl- selectivity filter; other site 1278073022774 Cl- binding residues [ion binding]; other site 1278073022775 pore gating glutamate residue; other site 1278073022776 dimer interface [polypeptide binding]; other site 1278073022777 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1278073022778 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1278073022779 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1278073022780 active site 1278073022781 ATP binding site [chemical binding]; other site 1278073022782 substrate binding site [chemical binding]; other site 1278073022783 activation loop (A-loop); other site 1278073022784 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1278073022785 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1278073022786 sequence-specific DNA binding site [nucleotide binding]; other site 1278073022787 salt bridge; other site 1278073022788 Response regulator receiver domain; Region: Response_reg; pfam00072 1278073022789 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1278073022790 active site 1278073022791 phosphorylation site [posttranslational modification] 1278073022792 intermolecular recognition site; other site 1278073022793 dimerization interface [polypeptide binding]; other site 1278073022794 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 1278073022795 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1278073022796 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 1278073022797 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1278073022798 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1278073022799 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1278073022800 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1278073022801 ParB-like nuclease domain; Region: ParB; smart00470 1278073022802 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1278073022803 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1278073022804 P-loop; other site 1278073022805 Magnesium ion binding site [ion binding]; other site 1278073022806 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1278073022807 Magnesium ion binding site [ion binding]; other site 1278073022808 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1278073022809 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1278073022810 active site 1278073022811 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1278073022812 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1278073022813 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1278073022814 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1278073022815 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1278073022816 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1278073022817 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1278073022818 putative substrate translocation pore; other site 1278073022819 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1278073022820 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1278073022821 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1278073022822 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1278073022823 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1278073022824 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1278073022825 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1278073022826 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 1278073022827 Homo sapiens 239FB and related proteins, metallophosphatase domain; Region: MPP_239FB; cd07379 1278073022828 putative active site [active] 1278073022829 putative metal binding site [ion binding]; other site 1278073022830 signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705 1278073022831 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1278073022832 tandem repeat interface [polypeptide binding]; other site 1278073022833 oligomer interface [polypeptide binding]; other site 1278073022834 active site residues [active] 1278073022835 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1278073022836 tandem repeat interface [polypeptide binding]; other site 1278073022837 oligomer interface [polypeptide binding]; other site 1278073022838 active site residues [active] 1278073022839 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1278073022840 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1278073022841 putative active site [active] 1278073022842 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1278073022843 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1278073022844 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1278073022845 G1 box; other site 1278073022846 GTP/Mg2+ binding site [chemical binding]; other site 1278073022847 Switch I region; other site 1278073022848 G2 box; other site 1278073022849 Switch II region; other site 1278073022850 G3 box; other site 1278073022851 G4 box; other site 1278073022852 G5 box; other site 1278073022853 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1278073022854 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1278073022855 G-X-X-G motif; other site 1278073022856 R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich...; Region: R3H; cl00297 1278073022857 RxxxH motif; other site 1278073022858 membrane protein insertase; Provisional; Region: PRK01318 1278073022859 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1278073022860 Haemolytic domain; Region: Haemolytic; pfam01809 1278073022861 Ribonuclease P; Region: Ribonuclease_P; pfam00825 1278073022862 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399