-- dump date 20140619_162209 -- class Genbank::misc_feature -- table misc_feature_note -- id note 246197000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 246197000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 246197000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197000004 Walker A motif; other site 246197000005 ATP binding site [chemical binding]; other site 246197000006 Walker B motif; other site 246197000007 arginine finger; other site 246197000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 246197000009 DnaA box-binding interface [nucleotide binding]; other site 246197000010 HEAT repeats; Region: HEAT_2; pfam13646 246197000011 HEAT repeats; Region: HEAT_2; pfam13646 246197000012 FOG: CBS domain [General function prediction only]; Region: COG0517 246197000013 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 246197000014 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 246197000015 H+ Antiporter protein; Region: 2A0121; TIGR00900 246197000016 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246197000017 putative substrate translocation pore; other site 246197000018 Tetratricopeptide repeat; Region: TPR_16; pfam13432 246197000019 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 246197000020 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 246197000021 putative active site [active] 246197000022 putative metal binding site [ion binding]; other site 246197000023 DoxX; Region: DoxX; pfam07681 246197000024 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 246197000025 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197000026 S-adenosylmethionine binding site [chemical binding]; other site 246197000027 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775 246197000028 HipA-like N-terminal domain; Region: HipA_N; pfam07805 246197000029 HipA-like C-terminal domain; Region: HipA_C; pfam07804 246197000030 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 246197000031 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 246197000032 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 246197000033 glutathione synthetase; Provisional; Region: PRK05246 246197000034 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 246197000035 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 246197000036 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197000037 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197000038 active site 246197000039 ATP binding site [chemical binding]; other site 246197000040 substrate binding site [chemical binding]; other site 246197000041 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246197000042 activation loop (A-loop); other site 246197000043 activation loop (A-loop); other site 246197000044 EB module; Region: EB; pfam01683 246197000045 Protein of unknown function (DUF429); Region: DUF429; pfam04250 246197000046 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 246197000047 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246197000048 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197000049 active site 246197000050 ATP binding site [chemical binding]; other site 246197000051 substrate binding site [chemical binding]; other site 246197000052 activation loop (A-loop); other site 246197000053 PEGA domain; Region: PEGA; pfam08308 246197000054 ribonuclease R; Region: RNase_R; TIGR02063 246197000055 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 246197000056 RNB domain; Region: RNB; pfam00773 246197000057 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 246197000058 RNA binding site [nucleotide binding]; other site 246197000059 Domain of unknown function (DUF4329); Region: DUF4329; pfam14220 246197000060 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 246197000061 NYN domain; Region: NYN; pfam01936 246197000062 putative metal binding site [ion binding]; other site 246197000063 Uncharacterized conserved protein [Function unknown]; Region: COG1432 246197000064 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146 246197000065 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 246197000066 binding surface 246197000067 TPR motif; other site 246197000068 Tetratricopeptide repeat; Region: TPR_16; pfam13432 246197000069 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 246197000070 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 246197000071 NMT1-like family; Region: NMT1_2; pfam13379 246197000072 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 246197000073 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 246197000074 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246197000075 dimer interface [polypeptide binding]; other site 246197000076 conserved gate region; other site 246197000077 putative PBP binding loops; other site 246197000078 ABC-ATPase subunit interface; other site 246197000079 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 246197000080 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 246197000081 Walker A/P-loop; other site 246197000082 ATP binding site [chemical binding]; other site 246197000083 Q-loop/lid; other site 246197000084 ABC transporter signature motif; other site 246197000085 Walker B; other site 246197000086 D-loop; other site 246197000087 H-loop/switch region; other site 246197000088 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 246197000089 Glucose dehydrogenase; Region: glucose_DH; cd08230 246197000090 NADP binding site [chemical binding]; other site 246197000091 catalytic Zn binding site [ion binding]; other site 246197000092 structural Zn binding site [ion binding]; other site 246197000093 dimer interface [polypeptide binding]; other site 246197000094 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 246197000095 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 246197000096 conserved hypothetical protein; Region: TIGR02270 246197000097 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 246197000098 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 246197000099 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 246197000100 Uncharacterized conserved protein [Function unknown]; Region: COG4850 246197000101 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 246197000102 polyphosphate kinase; Provisional; Region: PRK05443 246197000103 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 246197000104 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 246197000105 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 246197000106 putative domain interface [polypeptide binding]; other site 246197000107 putative active site [active] 246197000108 catalytic site [active] 246197000109 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 246197000110 putative domain interface [polypeptide binding]; other site 246197000111 putative active site [active] 246197000112 catalytic site [active] 246197000113 CHASE3 domain; Region: CHASE3; cl05000 246197000114 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246197000115 PAS domain; Region: PAS_9; pfam13426 246197000116 putative active site [active] 246197000117 heme pocket [chemical binding]; other site 246197000118 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 246197000119 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 246197000120 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197000121 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197000122 ATP binding site [chemical binding]; other site 246197000123 Mg2+ binding site [ion binding]; other site 246197000124 G-X-G motif; other site 246197000125 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 246197000126 Cupin domain; Region: Cupin_2; cl17218 246197000127 Myxococcus xanthus paralogous domain TIGR02266; Region: gmx_TIGR02266 246197000128 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 246197000129 hypothetical protein; Reviewed; Region: PRK09588 246197000130 RNA polymerase sigma-70 factor, Myxococcales family 1; Region: Sig-70_gmx1; TIGR03001 246197000131 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246197000132 DNA binding residues [nucleotide binding] 246197000133 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246197000134 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246197000135 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197000136 active site 246197000137 ATP binding site [chemical binding]; other site 246197000138 substrate binding site [chemical binding]; other site 246197000139 activation loop (A-loop); other site 246197000140 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 246197000141 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 246197000142 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 246197000143 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 246197000144 CoenzymeA binding site [chemical binding]; other site 246197000145 subunit interaction site [polypeptide binding]; other site 246197000146 PHB binding site; other site 246197000147 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 246197000148 CoenzymeA binding site [chemical binding]; other site 246197000149 subunit interaction site [polypeptide binding]; other site 246197000150 PHB binding site; other site 246197000151 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 246197000152 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 246197000153 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 246197000154 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 246197000155 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246197000156 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246197000157 active site 246197000158 Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330 246197000159 putative ADP-ribose binding site [chemical binding]; other site 246197000160 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246197000161 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246197000162 NAD(P) binding site [chemical binding]; other site 246197000163 active site 246197000164 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246197000165 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246197000166 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 246197000167 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 246197000168 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 246197000169 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 246197000170 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 246197000171 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 246197000172 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 246197000173 ATP-grasp domain; Region: ATP-grasp_4; cl17255 246197000174 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 246197000175 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 246197000176 carboxyltransferase (CT) interaction site; other site 246197000177 biotinylation site [posttranslational modification]; other site 246197000178 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 246197000179 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 246197000180 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 246197000181 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246197000182 putative substrate translocation pore; other site 246197000183 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 246197000184 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 246197000185 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 246197000186 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 246197000187 putative C-terminal domain interface [polypeptide binding]; other site 246197000188 putative GSH binding site (G-site) [chemical binding]; other site 246197000189 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 246197000190 putative dimer interface [polypeptide binding]; other site 246197000191 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 246197000192 dimer interface [polypeptide binding]; other site 246197000193 N-terminal domain interface [polypeptide binding]; other site 246197000194 putative substrate binding pocket (H-site) [chemical binding]; other site 246197000195 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246197000196 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246197000197 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 246197000198 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 246197000199 HlyD family secretion protein; Region: HlyD_3; pfam13437 246197000200 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 246197000201 Domain of unknown function DUF59; Region: DUF59; cl00941 246197000202 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246197000203 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246197000204 putative active site [active] 246197000205 heme pocket [chemical binding]; other site 246197000206 PAS domain S-box; Region: sensory_box; TIGR00229 246197000207 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246197000208 putative active site [active] 246197000209 heme pocket [chemical binding]; other site 246197000210 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197000211 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197000212 dimer interface [polypeptide binding]; other site 246197000213 phosphorylation site [posttranslational modification] 246197000214 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197000215 ATP binding site [chemical binding]; other site 246197000216 Mg2+ binding site [ion binding]; other site 246197000217 G-X-G motif; other site 246197000218 Response regulator receiver domain; Region: Response_reg; pfam00072 246197000219 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197000220 active site 246197000221 phosphorylation site [posttranslational modification] 246197000222 intermolecular recognition site; other site 246197000223 dimerization interface [polypeptide binding]; other site 246197000224 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 246197000225 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197000226 S-adenosylmethionine binding site [chemical binding]; other site 246197000227 HipA N-terminal domain; Region: Couple_hipA; pfam13657 246197000228 HipA-like N-terminal domain; Region: HipA_N; pfam07805 246197000229 HipA-like C-terminal domain; Region: HipA_C; pfam07804 246197000230 Uncharacterized conserved protein [Function unknown]; Region: COG1479 246197000231 Protein of unknown function DUF262; Region: DUF262; pfam03235 246197000232 Protein of unknown function DUF262; Region: DUF262; pfam03235 246197000233 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 246197000234 PA_M28_2: Protease-associated (PA) domain, peptidase family M28, subfamily-2. A subfamily of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic zinc ions; Region: PA_M28_2; cd04815 246197000235 PA/protease or protease-like domain interface [polypeptide binding]; other site 246197000236 M28 Zn-Peptidase Plasma glutamate carboxypeptidase; Region: M28_Pgcp_like; cd03883 246197000237 Peptidase family M28; Region: Peptidase_M28; pfam04389 246197000238 metal binding site [ion binding]; metal-binding site 246197000239 Transcriptional regulator; Region: Rrf2; cl17282 246197000240 Phosphotransferase enzyme family; Region: APH; pfam01636 246197000241 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 246197000242 active site 246197000243 substrate binding site [chemical binding]; other site 246197000244 ATP binding site [chemical binding]; other site 246197000245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246197000246 putative substrate translocation pore; other site 246197000247 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246197000248 FG-GAP repeat; Region: FG-GAP; pfam01839 246197000249 Family description; Region: VCBS; pfam13517 246197000250 Family description; Region: VCBS; pfam13517 246197000251 Lysyl oxidase; Region: Lysyl_oxidase; pfam01186 246197000252 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 246197000253 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 246197000254 FtsX-like permease family; Region: FtsX; pfam02687 246197000255 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 246197000256 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 246197000257 FtsX-like permease family; Region: FtsX; pfam02687 246197000258 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 246197000259 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 246197000260 putative active site [active] 246197000261 catalytic site [active] 246197000262 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 246197000263 putative active site [active] 246197000264 catalytic site [active] 246197000265 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246197000266 Coenzyme A binding pocket [chemical binding]; other site 246197000267 Protein of unknown function (DUF770); Region: DUF770; cl01402 246197000268 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 246197000269 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 246197000270 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 246197000271 N-acetyl-D-glucosamine binding site [chemical binding]; other site 246197000272 catalytic residue [active] 246197000273 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 246197000274 putative active site [active] 246197000275 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246197000276 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 246197000277 phosphopeptide binding site; other site 246197000278 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 246197000279 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197000280 Walker A motif; other site 246197000281 ATP binding site [chemical binding]; other site 246197000282 Walker B motif; other site 246197000283 arginine finger; other site 246197000284 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 246197000285 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197000286 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197000287 active site 246197000288 ATP binding site [chemical binding]; other site 246197000289 substrate binding site [chemical binding]; other site 246197000290 activation loop (A-loop); other site 246197000291 Tetratricopeptide repeat; Region: TPR_12; pfam13424 246197000292 Tetratricopeptide repeat; Region: TPR_10; pfam13374 246197000293 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 246197000294 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 246197000295 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 246197000296 tetrameric interface [polypeptide binding]; other site 246197000297 NAD binding site [chemical binding]; other site 246197000298 catalytic residues [active] 246197000299 hypothetical protein; Validated; Region: PRK07198 246197000300 GTP cyclohydrolase N terminal; Region: GTP_CH_N; pfam12471 246197000301 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 246197000302 dimerization interface [polypeptide binding]; other site 246197000303 active site 246197000304 Protein of unknown function (DUF1688); Region: DUF1688; pfam07958 246197000305 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 246197000306 active site 246197000307 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 246197000308 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 246197000309 putative active site [active] 246197000310 putative metal binding site [ion binding]; other site 246197000311 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 246197000312 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 246197000313 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 246197000314 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 246197000315 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 246197000316 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 246197000317 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 246197000318 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 246197000319 Cl- selectivity filter; other site 246197000320 Cl- binding residues [ion binding]; other site 246197000321 pore gating glutamate residue; other site 246197000322 dimer interface [polypeptide binding]; other site 246197000323 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 246197000324 active site 246197000325 oxyanion hole [active] 246197000326 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 246197000327 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 246197000328 putative active site [active] 246197000329 catalytic triad [active] 246197000330 putative dimer interface [polypeptide binding]; other site 246197000331 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 246197000332 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 246197000333 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 246197000334 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 246197000335 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 246197000336 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 246197000337 putative active site [active] 246197000338 putative NTP binding site [chemical binding]; other site 246197000339 putative nucleic acid binding site [nucleotide binding]; other site 246197000340 WGR domain; Region: WGR; cl01581 246197000341 FOG: WD40 repeat [General function prediction only]; Region: COG2319 246197000342 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 246197000343 structural tetrad; other site 246197000344 HEAT repeats; Region: HEAT_2; pfam13646 246197000345 HEAT repeats; Region: HEAT_2; pfam13646 246197000346 HEAT repeats; Region: HEAT_2; pfam13646 246197000347 HEAT repeats; Region: HEAT_2; pfam13646 246197000348 Cupin superfamily protein; Region: Cupin_4; pfam08007 246197000349 Scramblase; Region: Scramblase; pfam03803 246197000350 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197000351 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197000352 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197000353 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197000354 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197000355 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197000356 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197000357 Domain of unknown function (DUF4389); Region: DUF4389; pfam14333 246197000358 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 246197000359 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 246197000360 putative acyl-acceptor binding pocket; other site 246197000361 P-loop containing region of AAA domain; Region: AAA_29; cl17516 246197000362 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 246197000363 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 246197000364 active site 246197000365 metal binding site [ion binding]; metal-binding site 246197000366 DNA binding site [nucleotide binding] 246197000367 Methyltransferase domain; Region: Methyltransf_23; pfam13489 246197000368 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197000369 S-adenosylmethionine binding site [chemical binding]; other site 246197000370 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197000371 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197000372 ATP binding site [chemical binding]; other site 246197000373 Mg2+ binding site [ion binding]; other site 246197000374 G-X-G motif; other site 246197000375 threonine and homoserine efflux system; Provisional; Region: PRK10532 246197000376 EamA-like transporter family; Region: EamA; pfam00892 246197000377 DNA methylase; Region: N6_N4_Mtase; cl17433 246197000378 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246197000379 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 246197000380 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 246197000381 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 246197000382 Moco binding site; other site 246197000383 metal coordination site [ion binding]; other site 246197000384 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 246197000385 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 246197000386 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 246197000387 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 246197000388 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 246197000389 Soluble P-type ATPase [General function prediction only]; Region: COG4087 246197000390 K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156 246197000391 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 246197000392 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 246197000393 Ligand Binding Site [chemical binding]; other site 246197000394 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246197000395 dimerization interface [polypeptide binding]; other site 246197000396 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 246197000397 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246197000398 putative active site [active] 246197000399 heme pocket [chemical binding]; other site 246197000400 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197000401 dimer interface [polypeptide binding]; other site 246197000402 phosphorylation site [posttranslational modification] 246197000403 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197000404 ATP binding site [chemical binding]; other site 246197000405 G-X-G motif; other site 246197000406 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 246197000407 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 246197000408 YgiT-type zinc finger domain; Region: YgiT_finger; TIGR03831 246197000409 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246197000410 non-specific DNA binding site [nucleotide binding]; other site 246197000411 salt bridge; other site 246197000412 sequence-specific DNA binding site [nucleotide binding]; other site 246197000413 Hemerythrin-like domain; Region: Hr-like; cd12108 246197000414 Fe binding site [ion binding]; other site 246197000415 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 246197000416 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197000417 active site 246197000418 phosphorylation site [posttranslational modification] 246197000419 intermolecular recognition site; other site 246197000420 dimerization interface [polypeptide binding]; other site 246197000421 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197000422 Walker A motif; other site 246197000423 ATP binding site [chemical binding]; other site 246197000424 Walker B motif; other site 246197000425 arginine finger; other site 246197000426 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 246197000427 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246197000428 dimerization interface [polypeptide binding]; other site 246197000429 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 246197000430 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 246197000431 dimer interface [polypeptide binding]; other site 246197000432 putative CheW interface [polypeptide binding]; other site 246197000433 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 246197000434 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 246197000435 Potassium binding sites [ion binding]; other site 246197000436 Cesium cation binding sites [ion binding]; other site 246197000437 PAS domain; Region: PAS; smart00091 246197000438 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197000439 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197000440 ATP binding site [chemical binding]; other site 246197000441 Mg2+ binding site [ion binding]; other site 246197000442 G-X-G motif; other site 246197000443 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 246197000444 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 246197000445 active site residue [active] 246197000446 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 246197000447 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 246197000448 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197000449 Walker A motif; other site 246197000450 ATP binding site [chemical binding]; other site 246197000451 Walker B motif; other site 246197000452 arginine finger; other site 246197000453 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 246197000454 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 246197000455 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 246197000456 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 246197000457 Domain of unknown function (DUF4329); Region: DUF4329; pfam14220 246197000458 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 246197000459 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 246197000460 Penicillinase repressor; Region: Pencillinase_R; pfam03965 246197000461 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 246197000462 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 246197000463 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 246197000464 metal ion-dependent adhesion site (MIDAS); other site 246197000465 PAS domain S-box; Region: sensory_box; TIGR00229 246197000466 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246197000467 putative active site [active] 246197000468 heme pocket [chemical binding]; other site 246197000469 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 246197000470 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246197000471 putative active site [active] 246197000472 heme pocket [chemical binding]; other site 246197000473 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 246197000474 PAS domain; Region: PAS_8; pfam13188 246197000475 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197000476 dimer interface [polypeptide binding]; other site 246197000477 phosphorylation site [posttranslational modification] 246197000478 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197000479 ATP binding site [chemical binding]; other site 246197000480 Mg2+ binding site [ion binding]; other site 246197000481 G-X-G motif; other site 246197000482 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 246197000483 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197000484 active site 246197000485 phosphorylation site [posttranslational modification] 246197000486 intermolecular recognition site; other site 246197000487 dimerization interface [polypeptide binding]; other site 246197000488 PAS domain; Region: PAS_9; pfam13426 246197000489 GAF domain; Region: GAF; cl17456 246197000490 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197000491 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197000492 dimer interface [polypeptide binding]; other site 246197000493 phosphorylation site [posttranslational modification] 246197000494 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197000495 ATP binding site [chemical binding]; other site 246197000496 Mg2+ binding site [ion binding]; other site 246197000497 G-X-G motif; other site 246197000498 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 246197000499 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246197000500 dimerization interface [polypeptide binding]; other site 246197000501 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197000502 dimer interface [polypeptide binding]; other site 246197000503 phosphorylation site [posttranslational modification] 246197000504 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197000505 ATP binding site [chemical binding]; other site 246197000506 Mg2+ binding site [ion binding]; other site 246197000507 G-X-G motif; other site 246197000508 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 246197000509 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 246197000510 active site residue [active] 246197000511 EamA-like transporter family; Region: EamA; pfam00892 246197000512 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 246197000513 EamA-like transporter family; Region: EamA; pfam00892 246197000514 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246197000515 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 246197000516 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 246197000517 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 246197000518 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 246197000519 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 246197000520 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 246197000521 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246197000522 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246197000523 DNA binding residues [nucleotide binding] 246197000524 Methyltransferase domain; Region: Methyltransf_31; pfam13847 246197000525 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197000526 S-adenosylmethionine binding site [chemical binding]; other site 246197000527 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 246197000528 Subtilase family; Region: Peptidase_S8; pfam00082 246197000529 active site 246197000530 catalytic residues [active] 246197000531 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 246197000532 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 246197000533 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 246197000534 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 246197000535 N-acetyl-D-glucosamine binding site [chemical binding]; other site 246197000536 catalytic residue [active] 246197000537 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 246197000538 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246197000539 NAD(P) binding site [chemical binding]; other site 246197000540 active site 246197000541 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 246197000542 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246197000543 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246197000544 homodimer interface [polypeptide binding]; other site 246197000545 catalytic residue [active] 246197000546 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 246197000547 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246197000548 putative DNA binding site [nucleotide binding]; other site 246197000549 putative Zn2+ binding site [ion binding]; other site 246197000550 AsnC family; Region: AsnC_trans_reg; pfam01037 246197000551 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246197000552 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246197000553 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 246197000554 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 246197000555 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 246197000556 dimer interface [polypeptide binding]; other site 246197000557 active site 246197000558 CoA binding pocket [chemical binding]; other site 246197000559 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 246197000560 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246197000561 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 246197000562 acyl-activating enzyme (AAE) consensus motif; other site 246197000563 acyl-activating enzyme (AAE) consensus motif; other site 246197000564 putative AMP binding site [chemical binding]; other site 246197000565 putative active site [active] 246197000566 putative CoA binding site [chemical binding]; other site 246197000567 extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502 246197000568 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 246197000569 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246197000570 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 246197000571 Lipase (class 2); Region: Lipase_2; pfam01674 246197000572 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 246197000573 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR3; cd08275 246197000574 putative NAD(P) binding site [chemical binding]; other site 246197000575 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 246197000576 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 246197000577 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246197000578 Bacterial Bile acid CoA ligases and similar proteins; Region: BACL_like; cd05929 246197000579 acyl-activating enzyme (AAE) consensus motif; other site 246197000580 acyl-activating enzyme (AAE) consensus motif; other site 246197000581 putative AMP binding site [chemical binding]; other site 246197000582 putative active site [active] 246197000583 putative CoA binding site [chemical binding]; other site 246197000584 sensory histidine kinase AtoS; Provisional; Region: PRK11360 246197000585 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 246197000586 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246197000587 dimerization interface [polypeptide binding]; other site 246197000588 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 246197000589 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 246197000590 dimer interface [polypeptide binding]; other site 246197000591 putative CheW interface [polypeptide binding]; other site 246197000592 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 246197000593 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246197000594 non-specific DNA binding site [nucleotide binding]; other site 246197000595 salt bridge; other site 246197000596 sequence-specific DNA binding site [nucleotide binding]; other site 246197000597 Response regulator receiver domain; Region: Response_reg; pfam00072 246197000598 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197000599 active site 246197000600 phosphorylation site [posttranslational modification] 246197000601 intermolecular recognition site; other site 246197000602 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197000603 dimerization interface [polypeptide binding]; other site 246197000604 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197000605 dimer interface [polypeptide binding]; other site 246197000606 phosphorylation site [posttranslational modification] 246197000607 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197000608 ATP binding site [chemical binding]; other site 246197000609 Mg2+ binding site [ion binding]; other site 246197000610 G-X-G motif; other site 246197000611 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197000612 Response regulator receiver domain; Region: Response_reg; pfam00072 246197000613 active site 246197000614 phosphorylation site [posttranslational modification] 246197000615 intermolecular recognition site; other site 246197000616 dimerization interface [polypeptide binding]; other site 246197000617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197000618 ATP binding site [chemical binding]; other site 246197000619 G-X-G motif; other site 246197000620 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 246197000621 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197000622 active site 246197000623 phosphorylation site [posttranslational modification] 246197000624 intermolecular recognition site; other site 246197000625 dimerization interface [polypeptide binding]; other site 246197000626 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 246197000627 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197000628 active site 246197000629 phosphorylation site [posttranslational modification] 246197000630 intermolecular recognition site; other site 246197000631 dimerization interface [polypeptide binding]; other site 246197000632 B12 binding domain; Region: B12-binding_2; pfam02607 246197000633 B12 binding domain; Region: B12-binding; pfam02310 246197000634 B12 binding site [chemical binding]; other site 246197000635 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 246197000636 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246197000637 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 246197000638 DNA polymerase III subunit beta; Validated; Region: PRK05643 246197000639 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 246197000640 putative DNA binding surface [nucleotide binding]; other site 246197000641 dimer interface [polypeptide binding]; other site 246197000642 beta-clamp/clamp loader binding surface; other site 246197000643 beta-clamp/translesion DNA polymerase binding surface; other site 246197000644 Domain of unknown function (DUF1990); Region: DUF1990; pfam09348 246197000645 Domain of unknown function (DUF1990); Region: DUF1990; cl01969 246197000646 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 246197000647 Predicted lipoprotein of unknown function (DUF2380); Region: DUF2380; pfam09533 246197000648 Protein of unknown function (Gmx_para_CXXCG); Region: Gmx_para_CXXCG; pfam09535 246197000649 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 246197000650 PAS fold; Region: PAS_4; pfam08448 246197000651 PAS fold; Region: PAS_4; pfam08448 246197000652 PAS domain; Region: PAS; smart00091 246197000653 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 246197000654 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197000655 dimer interface [polypeptide binding]; other site 246197000656 phosphorylation site [posttranslational modification] 246197000657 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197000658 ATP binding site [chemical binding]; other site 246197000659 Mg2+ binding site [ion binding]; other site 246197000660 G-X-G motif; other site 246197000661 recombination protein F; Reviewed; Region: recF; PRK00064 246197000662 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246197000663 Walker A/P-loop; other site 246197000664 ATP binding site [chemical binding]; other site 246197000665 Q-loop/lid; other site 246197000666 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246197000667 ABC transporter signature motif; other site 246197000668 Walker B; other site 246197000669 D-loop; other site 246197000670 H-loop/switch region; other site 246197000671 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 246197000672 Permease; Region: Permease; pfam02405 246197000673 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 246197000674 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 246197000675 Walker A/P-loop; other site 246197000676 ATP binding site [chemical binding]; other site 246197000677 Q-loop/lid; other site 246197000678 ABC transporter signature motif; other site 246197000679 Walker B; other site 246197000680 D-loop; other site 246197000681 H-loop/switch region; other site 246197000682 mce related protein; Region: MCE; pfam02470 246197000683 Myxococcus xanthus double-CXXCG motif paralogous family; Region: gmx_para_CXXCG; TIGR02264 246197000684 Myxococcus xanthus paralogous lipoprotein family TIGR02269; Region: TIGR02269 246197000685 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 246197000686 M20 Peptidases with simlarity to acetylornithine deacetylases; Region: M20_ArgE-related; cd08012 246197000687 metal binding site [ion binding]; metal-binding site 246197000688 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 246197000689 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246197000690 catalytic residue [active] 246197000691 Myxococcales-restricted protein, TIGR02265 family; Region: Mxa_TIGR02265 246197000692 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 246197000693 intermolecular recognition site; other site 246197000694 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197000695 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197000696 ATP binding site [chemical binding]; other site 246197000697 G-X-G motif; other site 246197000698 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197000699 active site 246197000700 phosphorylation site [posttranslational modification] 246197000701 intermolecular recognition site; other site 246197000702 dimerization interface [polypeptide binding]; other site 246197000703 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 246197000704 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 246197000705 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 246197000706 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246197000707 Ligand Binding Site [chemical binding]; other site 246197000708 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 246197000709 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246197000710 non-specific DNA binding site [nucleotide binding]; other site 246197000711 salt bridge; other site 246197000712 sequence-specific DNA binding site [nucleotide binding]; other site 246197000713 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246197000714 Coenzyme A binding pocket [chemical binding]; other site 246197000715 TIGR00255 family protein; Region: TIGR00255 246197000716 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 246197000717 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197000718 ATP binding site [chemical binding]; other site 246197000719 Mg2+ binding site [ion binding]; other site 246197000720 G-X-G motif; other site 246197000721 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 246197000722 anchoring element; other site 246197000723 dimer interface [polypeptide binding]; other site 246197000724 ATP binding site [chemical binding]; other site 246197000725 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 246197000726 active site 246197000727 putative metal-binding site [ion binding]; other site 246197000728 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 246197000729 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197000730 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197000731 active site 246197000732 ATP binding site [chemical binding]; other site 246197000733 substrate binding site [chemical binding]; other site 246197000734 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246197000735 substrate binding site [chemical binding]; other site 246197000736 activation loop (A-loop); other site 246197000737 activation loop (A-loop); other site 246197000738 PEGA domain; Region: PEGA; pfam08308 246197000739 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 246197000740 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 246197000741 active site 246197000742 metal binding site [ion binding]; metal-binding site 246197000743 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 246197000744 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 246197000745 NAD binding site [chemical binding]; other site 246197000746 catalytic Zn binding site [ion binding]; other site 246197000747 structural Zn binding site [ion binding]; other site 246197000748 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 246197000749 putative hydrophobic ligand binding site [chemical binding]; other site 246197000750 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197000751 TonB-dependent receptor; Region: TonB-Xanth-Caul; TIGR01782 246197000752 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 246197000753 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 246197000754 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 246197000755 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 246197000756 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 246197000757 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 246197000758 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 246197000759 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 246197000760 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 246197000761 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 246197000762 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 246197000763 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 246197000764 Ribosome-binding factor A; Region: RBFA; pfam02033 246197000765 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 246197000766 hypothetical protein; Reviewed; Region: PRK09588 246197000767 Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cd11375 246197000768 active site 246197000769 Zn binding site [ion binding]; other site 246197000770 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 246197000771 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 246197000772 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 246197000773 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 246197000774 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 246197000775 Cysteine-rich domain; Region: CCG; pfam02754 246197000776 Cysteine-rich domain; Region: CCG; pfam02754 246197000777 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 246197000778 metal ion-dependent adhesion site (MIDAS); other site 246197000779 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 246197000780 Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232 246197000781 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 246197000782 DsbD alpha interface [polypeptide binding]; other site 246197000783 catalytic residues [active] 246197000784 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 246197000785 putative catalytic residue [active] 246197000786 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246197000787 putative substrate translocation pore; other site 246197000788 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 246197000789 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 246197000790 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 246197000791 protein binding site [polypeptide binding]; other site 246197000792 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 246197000793 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 246197000794 protein binding site [polypeptide binding]; other site 246197000795 HNH endonuclease; Region: HNH_2; pfam13391 246197000796 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 246197000797 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 246197000798 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 246197000799 active site 246197000800 TDP-binding site; other site 246197000801 acceptor substrate-binding pocket; other site 246197000802 homodimer interface [polypeptide binding]; other site 246197000803 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 246197000804 Ligand Binding Site [chemical binding]; other site 246197000805 Molecular Tunnel; other site 246197000806 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246197000807 FeS/SAM binding site; other site 246197000808 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 246197000809 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 246197000810 active site 246197000811 catalytic tetrad [active] 246197000812 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 246197000813 PAS domain; Region: PAS_9; pfam13426 246197000814 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 246197000815 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197000816 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 246197000817 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197000818 dimer interface [polypeptide binding]; other site 246197000819 phosphorylation site [posttranslational modification] 246197000820 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197000821 ATP binding site [chemical binding]; other site 246197000822 Mg2+ binding site [ion binding]; other site 246197000823 G-X-G motif; other site 246197000824 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246197000825 acyl-activating enzyme (AAE) consensus motif; other site 246197000826 active site 246197000827 AMP binding site [chemical binding]; other site 246197000828 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 246197000829 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 246197000830 Walker A motif; other site 246197000831 ATP binding site [chemical binding]; other site 246197000832 Walker B motif; other site 246197000833 arginine finger; other site 246197000834 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246197000835 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246197000836 DNA binding residues [nucleotide binding] 246197000837 dimerization interface [polypeptide binding]; other site 246197000838 Panthothenate kinase [Coenzyme metabolism]; Region: CoaA; COG1072 246197000839 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 246197000840 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 246197000841 active site 246197000842 PAS domain S-box; Region: sensory_box; TIGR00229 246197000843 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246197000844 putative active site [active] 246197000845 heme pocket [chemical binding]; other site 246197000846 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197000847 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197000848 dimer interface [polypeptide binding]; other site 246197000849 phosphorylation site [posttranslational modification] 246197000850 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197000851 ATP binding site [chemical binding]; other site 246197000852 Mg2+ binding site [ion binding]; other site 246197000853 G-X-G motif; other site 246197000854 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 246197000855 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197000856 active site 246197000857 phosphorylation site [posttranslational modification] 246197000858 intermolecular recognition site; other site 246197000859 dimerization interface [polypeptide binding]; other site 246197000860 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 246197000861 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 246197000862 Protein of unknown function, DUF482; Region: DUF482; pfam04339 246197000863 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 246197000864 Fatty acid desaturase; Region: FA_desaturase; pfam00487 246197000865 Di-iron ligands [ion binding]; other site 246197000866 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 246197000867 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 246197000868 inhibitor-cofactor binding pocket; inhibition site 246197000869 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246197000870 catalytic residue [active] 246197000871 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 246197000872 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 246197000873 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 246197000874 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 246197000875 Phage Tail Collar Domain; Region: Collar; pfam07484 246197000876 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 246197000877 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246197000878 Coenzyme A binding pocket [chemical binding]; other site 246197000879 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 246197000880 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 246197000881 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 246197000882 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 246197000883 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 246197000884 ligand binding site [chemical binding]; other site 246197000885 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 246197000886 5'-3' exonuclease; Region: 53EXOc; smart00475 246197000887 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 246197000888 active site 246197000889 metal binding site 1 [ion binding]; metal-binding site 246197000890 putative 5' ssDNA interaction site; other site 246197000891 metal binding site 3; metal-binding site 246197000892 metal binding site 2 [ion binding]; metal-binding site 246197000893 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 246197000894 putative DNA binding site [nucleotide binding]; other site 246197000895 putative metal binding site [ion binding]; other site 246197000896 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197000897 Response regulator receiver domain; Region: Response_reg; pfam00072 246197000898 active site 246197000899 phosphorylation site [posttranslational modification] 246197000900 intermolecular recognition site; other site 246197000901 dimerization interface [polypeptide binding]; other site 246197000902 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246197000903 PAS fold; Region: PAS_3; pfam08447 246197000904 putative active site [active] 246197000905 heme pocket [chemical binding]; other site 246197000906 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 246197000907 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197000908 dimer interface [polypeptide binding]; other site 246197000909 phosphorylation site [posttranslational modification] 246197000910 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197000911 ATP binding site [chemical binding]; other site 246197000912 Mg2+ binding site [ion binding]; other site 246197000913 G-X-G motif; other site 246197000914 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 246197000915 heme-binding site [chemical binding]; other site 246197000916 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 246197000917 Di-iron ligands [ion binding]; other site 246197000918 PAS domain S-box; Region: sensory_box; TIGR00229 246197000919 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246197000920 putative active site [active] 246197000921 heme pocket [chemical binding]; other site 246197000922 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197000923 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197000924 dimer interface [polypeptide binding]; other site 246197000925 phosphorylation site [posttranslational modification] 246197000926 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197000927 ATP binding site [chemical binding]; other site 246197000928 Mg2+ binding site [ion binding]; other site 246197000929 G-X-G motif; other site 246197000930 K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158 246197000931 potassium uptake protein; Region: kup; TIGR00794 246197000932 Myxococcales-restricted protein, TIGR02265 family; Region: Mxa_TIGR02265 246197000933 Deinococcus radiodurans DR1119 and related proteins, metallophosphatase domain; Region: MPP_DR1119; cd07393 246197000934 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 246197000935 putative active site [active] 246197000936 putative metal binding site [ion binding]; other site 246197000937 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 246197000938 amidase catalytic site [active] 246197000939 Zn binding residues [ion binding]; other site 246197000940 substrate binding site [chemical binding]; other site 246197000941 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 246197000942 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 246197000943 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 246197000944 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 246197000945 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 246197000946 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 246197000947 PAS domain S-box; Region: sensory_box; TIGR00229 246197000948 PAS domain; Region: PAS; smart00091 246197000949 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 246197000950 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246197000951 putative active site [active] 246197000952 heme pocket [chemical binding]; other site 246197000953 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197000954 dimer interface [polypeptide binding]; other site 246197000955 phosphorylation site [posttranslational modification] 246197000956 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197000957 ATP binding site [chemical binding]; other site 246197000958 Mg2+ binding site [ion binding]; other site 246197000959 G-X-G motif; other site 246197000960 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 246197000961 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 246197000962 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 246197000963 ATP-grasp domain; Region: ATP-grasp_4; cl17255 246197000964 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 246197000965 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246197000966 phosphopeptide binding site; other site 246197000967 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 246197000968 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197000969 Walker A motif; other site 246197000970 ATP binding site [chemical binding]; other site 246197000971 Walker B motif; other site 246197000972 arginine finger; other site 246197000973 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 246197000974 TadE-like protein; Region: TadE; pfam07811 246197000975 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 246197000976 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 246197000977 active site 246197000978 HIGH motif; other site 246197000979 nucleotide binding site [chemical binding]; other site 246197000980 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 246197000981 active site 246197000982 KMSKS motif; other site 246197000983 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 246197000984 tRNA binding surface [nucleotide binding]; other site 246197000985 anticodon binding site; other site 246197000986 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 246197000987 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 246197000988 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 246197000989 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 246197000990 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 246197000991 Ub domain fused to Mut7-C; Region: Ub-Mut7C; pfam14451 246197000992 Uncharacterized conserved protein [Function unknown]; Region: COG1656 246197000993 Protein of unknown function DUF82; Region: DUF82; pfam01927 246197000994 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 246197000995 putative catalytic site [active] 246197000996 putative metal binding site [ion binding]; other site 246197000997 putative phosphate binding site [ion binding]; other site 246197000998 lipoprotein signal peptidase; Provisional; Region: PRK14773 246197000999 lipoprotein signal peptidase; Provisional; Region: PRK14773 246197001000 lipoprotein signal peptidase; Provisional; Region: PRK14787 246197001001 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 246197001002 short chain dehydrogenase; Provisional; Region: PRK05650 246197001003 classical (c) SDRs; Region: SDR_c; cd05233 246197001004 NAD(P) binding site [chemical binding]; other site 246197001005 active site 246197001006 TPR repeat; Region: TPR_11; pfam13414 246197001007 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 246197001008 MgtE intracellular N domain; Region: MgtE_N; smart00924 246197001009 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 246197001010 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 246197001011 Divalent cation transporter; Region: MgtE; pfam01769 246197001012 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 246197001013 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 246197001014 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 246197001015 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 246197001016 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 246197001017 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 246197001018 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_15; cd07264 246197001019 HTH domain; Region: HTH_11; pfam08279 246197001020 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 246197001021 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246197001022 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 246197001023 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 246197001024 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 246197001025 active site 246197001026 catalytic tetrad [active] 246197001027 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 246197001028 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 246197001029 inhibitor-cofactor binding pocket; inhibition site 246197001030 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246197001031 catalytic residue [active] 246197001032 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197001033 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197001034 active site 246197001035 ATP binding site [chemical binding]; other site 246197001036 substrate binding site [chemical binding]; other site 246197001037 activation loop (A-loop); other site 246197001038 PAS domain; Region: PAS_8; pfam13188 246197001039 PAS domain S-box; Region: sensory_box; TIGR00229 246197001040 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 246197001041 GAF domain; Region: GAF; pfam01590 246197001042 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 246197001043 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 246197001044 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197001045 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197001046 dimer interface [polypeptide binding]; other site 246197001047 phosphorylation site [posttranslational modification] 246197001048 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197001049 ATP binding site [chemical binding]; other site 246197001050 Mg2+ binding site [ion binding]; other site 246197001051 G-X-G motif; other site 246197001052 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 246197001053 substrate binding site [chemical binding]; other site 246197001054 ATP synthase A chain; Region: ATP-synt_A; cl00413 246197001055 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 246197001056 ATP synthase subunit C; Region: ATP-synt_C; cl00466 246197001057 F0F1 ATP synthase subunit B; Provisional; Region: PRK13461 246197001058 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 246197001059 GTP-binding protein YchF; Reviewed; Region: PRK09601 246197001060 YchF GTPase; Region: YchF; cd01900 246197001061 G1 box; other site 246197001062 GTP/Mg2+ binding site [chemical binding]; other site 246197001063 Switch I region; other site 246197001064 G2 box; other site 246197001065 Switch II region; other site 246197001066 G3 box; other site 246197001067 G4 box; other site 246197001068 G5 box; other site 246197001069 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 246197001070 Helix-turn-helix domain; Region: HTH_17; pfam12728 246197001071 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_2; cd06102 246197001072 Citrate synthase; Region: Citrate_synt; pfam00285 246197001073 dimer interface [polypeptide binding]; other site 246197001074 active site 246197001075 oxalacetate/citrate binding site [chemical binding]; other site 246197001076 citrylCoA binding site [chemical binding]; other site 246197001077 coenzyme A binding site [chemical binding]; other site 246197001078 catalytic triad [active] 246197001079 Methyltransferase domain; Region: Methyltransf_31; pfam13847 246197001080 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197001081 S-adenosylmethionine binding site [chemical binding]; other site 246197001082 Cupin domain; Region: Cupin_2; cl17218 246197001083 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 246197001084 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 246197001085 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 246197001086 putative active site [active] 246197001087 putative metal binding site [ion binding]; other site 246197001088 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 246197001089 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 246197001090 Walker A motif; other site 246197001091 ATP binding site [chemical binding]; other site 246197001092 Walker B motif; other site 246197001093 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 246197001094 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 246197001095 NlpC/P60 family; Region: NLPC_P60; cl17555 246197001096 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 246197001097 active site 246197001098 catalytic residues [active] 246197001099 Uncharacterized conserved protein [Function unknown]; Region: COG1915 246197001100 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cl04528 246197001101 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 246197001102 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 246197001103 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246197001104 active site 246197001105 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 246197001106 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 246197001107 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 246197001108 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 246197001109 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 246197001110 Methyltransferase domain; Region: Methyltransf_23; pfam13489 246197001111 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197001112 S-adenosylmethionine binding site [chemical binding]; other site 246197001113 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 246197001114 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 246197001115 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 246197001116 active site 246197001117 catalytic site [active] 246197001118 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 246197001119 MOSC domain; Region: MOSC; pfam03473 246197001120 3-alpha domain; Region: 3-alpha; pfam03475 246197001121 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 246197001122 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 246197001123 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 246197001124 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 246197001125 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 246197001126 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 246197001127 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246197001128 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 246197001129 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 246197001130 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 246197001131 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 246197001132 active site 246197001133 catalytic residues [active] 246197001134 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 246197001135 Predicted membrane protein [Function unknown]; Region: COG2246 246197001136 GtrA-like protein; Region: GtrA; pfam04138 246197001137 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 246197001138 active site 246197001139 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 246197001140 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 246197001141 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 246197001142 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 246197001143 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 246197001144 putative NAD(P) binding site [chemical binding]; other site 246197001145 putative substrate binding site [chemical binding]; other site 246197001146 catalytic Zn binding site [ion binding]; other site 246197001147 structural Zn binding site [ion binding]; other site 246197001148 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 246197001149 30S subunit binding site; other site 246197001150 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 246197001151 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197001152 dimer interface [polypeptide binding]; other site 246197001153 phosphorylation site [posttranslational modification] 246197001154 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197001155 ATP binding site [chemical binding]; other site 246197001156 Mg2+ binding site [ion binding]; other site 246197001157 G-X-G motif; other site 246197001158 Response regulator receiver domain; Region: Response_reg; pfam00072 246197001159 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197001160 active site 246197001161 phosphorylation site [posttranslational modification] 246197001162 intermolecular recognition site; other site 246197001163 dimerization interface [polypeptide binding]; other site 246197001164 Response regulator receiver domain; Region: Response_reg; pfam00072 246197001165 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197001166 active site 246197001167 phosphorylation site [posttranslational modification] 246197001168 intermolecular recognition site; other site 246197001169 dimerization interface [polypeptide binding]; other site 246197001170 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197001171 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197001172 ATP binding site [chemical binding]; other site 246197001173 Mg2+ binding site [ion binding]; other site 246197001174 G-X-G motif; other site 246197001175 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 246197001176 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197001177 active site 246197001178 phosphorylation site [posttranslational modification] 246197001179 intermolecular recognition site; other site 246197001180 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 246197001181 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 246197001182 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 246197001183 active site 246197001184 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197001185 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 246197001186 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 246197001187 SurA N-terminal domain; Region: SurA_N; pfam09312 246197001188 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 246197001189 SurA N-terminal domain; Region: SurA_N_3; cl07813 246197001190 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 246197001191 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 246197001192 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246197001193 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 246197001194 GIY-YIG motif/motif A; other site 246197001195 putative active site [active] 246197001196 putative metal binding site [ion binding]; other site 246197001197 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349 246197001198 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246197001199 FeS/SAM binding site; other site 246197001200 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 246197001201 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 246197001202 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 246197001203 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 246197001204 putative NADH binding site [chemical binding]; other site 246197001205 putative active site [active] 246197001206 nudix motif; other site 246197001207 putative metal binding site [ion binding]; other site 246197001208 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 246197001209 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 246197001210 dimer interface [polypeptide binding]; other site 246197001211 active site 246197001212 metal binding site [ion binding]; metal-binding site 246197001213 glutathione binding site [chemical binding]; other site 246197001214 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 246197001215 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 246197001216 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 246197001217 FMN binding site [chemical binding]; other site 246197001218 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 246197001219 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 246197001220 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 246197001221 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 246197001222 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 246197001223 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_15; cd07264 246197001224 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246197001225 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 246197001226 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 246197001227 glutaminase active site [active] 246197001228 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 246197001229 dimer interface [polypeptide binding]; other site 246197001230 active site 246197001231 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 246197001232 dimer interface [polypeptide binding]; other site 246197001233 active site 246197001234 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 246197001235 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 246197001236 putative DNA binding site [nucleotide binding]; other site 246197001237 AsnC family; Region: AsnC_trans_reg; pfam01037 246197001238 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 246197001239 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 246197001240 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 246197001241 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 246197001242 Methyltransferase domain; Region: Methyltransf_31; pfam13847 246197001243 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197001244 S-adenosylmethionine binding site [chemical binding]; other site 246197001245 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 246197001246 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 246197001247 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 246197001248 Homeodomain-like domain; Region: HTH_23; pfam13384 246197001249 Winged helix-turn helix; Region: HTH_29; pfam13551 246197001250 Homeodomain-like domain; Region: HTH_32; pfam13565 246197001251 Winged helix-turn helix; Region: HTH_33; pfam13592 246197001252 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246197001253 Coenzyme A binding pocket [chemical binding]; other site 246197001254 Tetratricopeptide repeat; Region: TPR_12; pfam13424 246197001255 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197001256 binding surface 246197001257 TPR motif; other site 246197001258 PEGA domain; Region: PEGA; pfam08308 246197001259 PEGA domain; Region: PEGA; pfam08308 246197001260 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 246197001261 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 246197001262 N-terminal plug; other site 246197001263 ligand-binding site [chemical binding]; other site 246197001264 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 246197001265 putative active site [active] 246197001266 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 246197001267 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197001268 Walker A motif; other site 246197001269 ATP binding site [chemical binding]; other site 246197001270 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 246197001271 AAA domain; Region: AAA_12; pfam13087 246197001272 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 246197001273 nucleotide binding site/active site [active] 246197001274 HIT family signature motif; other site 246197001275 catalytic residue [active] 246197001276 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197001277 Bacterial Ig-like domain; Region: Big_5; pfam13205 246197001278 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 246197001279 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197001280 active site 246197001281 phosphorylation site [posttranslational modification] 246197001282 intermolecular recognition site; other site 246197001283 dimerization interface [polypeptide binding]; other site 246197001284 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197001285 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197001286 active site 246197001287 ATP binding site [chemical binding]; other site 246197001288 substrate binding site [chemical binding]; other site 246197001289 activation loop (A-loop); other site 246197001290 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197001291 Uncharacterized conserved protein [Function unknown]; Region: COG1262 246197001292 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 246197001293 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 246197001294 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 246197001295 HlyD family secretion protein; Region: HlyD_3; pfam13437 246197001296 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 246197001297 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 246197001298 aspartate aminotransferase; Provisional; Region: PRK05764 246197001299 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246197001300 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246197001301 homodimer interface [polypeptide binding]; other site 246197001302 catalytic residue [active] 246197001303 TLC ATP/ADP transporter; Region: TLC; cl03940 246197001304 TLC ATP/ADP transporter; Region: TLC; cl03940 246197001305 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 246197001306 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246197001307 NAD(P) binding site [chemical binding]; other site 246197001308 active site 246197001309 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 246197001310 DNA topoisomerase III; Provisional; Region: PRK07726 246197001311 active site 246197001312 putative interdomain interaction site [polypeptide binding]; other site 246197001313 putative metal-binding site [ion binding]; other site 246197001314 putative nucleotide binding site [chemical binding]; other site 246197001315 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 246197001316 domain I; other site 246197001317 phosphate binding site [ion binding]; other site 246197001318 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 246197001319 domain II; other site 246197001320 domain III; other site 246197001321 nucleotide binding site [chemical binding]; other site 246197001322 DNA binding groove [nucleotide binding] 246197001323 catalytic site [active] 246197001324 domain IV; other site 246197001325 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 246197001326 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246197001327 ATP binding site [chemical binding]; other site 246197001328 putative Mg++ binding site [ion binding]; other site 246197001329 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246197001330 nucleotide binding region [chemical binding]; other site 246197001331 ATP-binding site [chemical binding]; other site 246197001332 HRDC domain; Region: HRDC; pfam00570 246197001333 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 246197001334 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 246197001335 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 246197001336 putative active site [active] 246197001337 catalytic site [active] 246197001338 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 246197001339 putative active site [active] 246197001340 catalytic site [active] 246197001341 Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279 246197001342 active site 246197001343 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 246197001344 Walker A motif; other site 246197001345 ATP binding site [chemical binding]; other site 246197001346 Walker B motif; other site 246197001347 arginine finger; other site 246197001348 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 246197001349 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 246197001350 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 246197001351 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 246197001352 catalytic site [active] 246197001353 active site 246197001354 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 246197001355 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 246197001356 sugar binding site [chemical binding]; other site 246197001357 hypothetical protein; Provisional; Region: PRK07907 246197001358 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_5; cd05682 246197001359 metal binding site [ion binding]; metal-binding site 246197001360 putative dimer interface [polypeptide binding]; other site 246197001361 Domain of unknown function (DUF4135); Region: DUF4135; pfam13575 246197001362 Uncharacterized conserved protein [Function unknown]; Region: COG2850 246197001363 Cupin-like domain; Region: Cupin_8; pfam13621 246197001364 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 246197001365 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 246197001366 putative C-terminal domain interface [polypeptide binding]; other site 246197001367 putative GSH binding site (G-site) [chemical binding]; other site 246197001368 putative dimer interface [polypeptide binding]; other site 246197001369 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 246197001370 dimer interface [polypeptide binding]; other site 246197001371 N-terminal domain interface [polypeptide binding]; other site 246197001372 putative substrate binding pocket (H-site) [chemical binding]; other site 246197001373 HEAT repeats; Region: HEAT_2; pfam13646 246197001374 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246197001375 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197001376 active site 246197001377 ATP binding site [chemical binding]; other site 246197001378 substrate binding site [chemical binding]; other site 246197001379 activation loop (A-loop); other site 246197001380 PEGA domain; Region: PEGA; pfam08308 246197001381 ABC-2 type transporter; Region: ABC2_membrane; cl17235 246197001382 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 246197001383 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 246197001384 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 246197001385 Walker A/P-loop; other site 246197001386 ATP binding site [chemical binding]; other site 246197001387 Q-loop/lid; other site 246197001388 ABC transporter signature motif; other site 246197001389 Walker B; other site 246197001390 D-loop; other site 246197001391 H-loop/switch region; other site 246197001392 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 246197001393 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 246197001394 active site 246197001395 metal binding site [ion binding]; metal-binding site 246197001396 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 246197001397 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246197001398 DNA-binding site [nucleotide binding]; DNA binding site 246197001399 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246197001400 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246197001401 homodimer interface [polypeptide binding]; other site 246197001402 catalytic residue [active] 246197001403 Cupin domain; Region: Cupin_2; pfam07883 246197001404 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 246197001405 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 246197001406 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 246197001407 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 246197001408 ABC transporter; Region: ABC_tran_2; pfam12848 246197001409 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 246197001410 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 246197001411 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 246197001412 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 246197001413 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 246197001414 heat shock protein HtpX; Provisional; Region: PRK05457 246197001415 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 246197001416 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 246197001417 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 246197001418 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 246197001419 Myxococcales-restricted protein, TIGR02265 family; Region: Mxa_TIGR02265 246197001420 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 246197001421 Putative esterase; Region: Esterase; pfam00756 246197001422 Catalytic site; other site 246197001423 Staphylococcal nuclease homologue; Region: SNase; pfam00565 246197001424 PAS domain; Region: PAS; smart00091 246197001425 PAS fold; Region: PAS_4; pfam08448 246197001426 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 246197001427 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 246197001428 putative active site [active] 246197001429 heme pocket [chemical binding]; other site 246197001430 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246197001431 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197001432 putative active site [active] 246197001433 heme pocket [chemical binding]; other site 246197001434 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197001435 dimer interface [polypeptide binding]; other site 246197001436 phosphorylation site [posttranslational modification] 246197001437 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197001438 ATP binding site [chemical binding]; other site 246197001439 Mg2+ binding site [ion binding]; other site 246197001440 G-X-G motif; other site 246197001441 Low molecular weight phosphatase family; Region: LMWPc; cl00105 246197001442 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 246197001443 active site 246197001444 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 246197001445 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 246197001446 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 246197001447 Protein of unknown function (DUF938); Region: DUF938; pfam06080 246197001448 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 246197001449 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 246197001450 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 246197001451 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 246197001452 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 246197001453 Protein of unknown function (DUF1175); Region: DUF1175; pfam06672 246197001454 MG2 domain; Region: A2M_N; pfam01835 246197001455 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 246197001456 Alpha-2-macroglobulin family; Region: A2M; pfam00207 246197001457 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 246197001458 Stage II sporulation protein; Region: SpoIID; pfam08486 246197001459 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 246197001460 HEAT repeats; Region: HEAT_2; pfam13646 246197001461 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 246197001462 active site 246197001463 TDP-binding site; other site 246197001464 acceptor substrate-binding pocket; other site 246197001465 homodimer interface [polypeptide binding]; other site 246197001466 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 246197001467 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246197001468 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 246197001469 Walker A/P-loop; other site 246197001470 ATP binding site [chemical binding]; other site 246197001471 Q-loop/lid; other site 246197001472 ABC transporter signature motif; other site 246197001473 Walker B; other site 246197001474 D-loop; other site 246197001475 H-loop/switch region; other site 246197001476 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 246197001477 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246197001478 conserved gate region; other site 246197001479 ABC-ATPase subunit interface; other site 246197001480 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 246197001481 Protein of unknown function DUF262; Region: DUF262; pfam03235 246197001482 Uncharacterized conserved protein [Function unknown]; Region: COG1479 246197001483 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 246197001484 Protein of unknown function (DUF2379); Region: DUF2379; cl15283 246197001485 Protein of unknown function (DUF2379); Region: DUF2379; pfam09543 246197001486 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 246197001487 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 246197001488 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 246197001489 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197001490 Walker A motif; other site 246197001491 ATP binding site [chemical binding]; other site 246197001492 Walker B motif; other site 246197001493 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 246197001494 Mechanosensitive ion channel; Region: MS_channel; pfam00924 246197001495 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 246197001496 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 246197001497 NAD(P) binding site [chemical binding]; other site 246197001498 catalytic residues [active] 246197001499 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 246197001500 active site 246197001501 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 246197001502 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 246197001503 putative active site [active] 246197001504 Zn binding site [ion binding]; other site 246197001505 serine O-acetyltransferase; Region: cysE; TIGR01172 246197001506 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 246197001507 putative CoA binding site [chemical binding]; other site 246197001508 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 246197001509 trimer interface [polypeptide binding]; other site 246197001510 active site 246197001511 substrate binding site [chemical binding]; other site 246197001512 CoA binding site [chemical binding]; other site 246197001513 PAS domain S-box; Region: sensory_box; TIGR00229 246197001514 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246197001515 putative active site [active] 246197001516 heme pocket [chemical binding]; other site 246197001517 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 246197001518 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 246197001519 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246197001520 putative active site [active] 246197001521 heme pocket [chemical binding]; other site 246197001522 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197001523 dimer interface [polypeptide binding]; other site 246197001524 phosphorylation site [posttranslational modification] 246197001525 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197001526 ATP binding site [chemical binding]; other site 246197001527 Mg2+ binding site [ion binding]; other site 246197001528 G-X-G motif; other site 246197001529 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; pfam04734 246197001530 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197001531 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197001532 active site 246197001533 ATP binding site [chemical binding]; other site 246197001534 substrate binding site [chemical binding]; other site 246197001535 activation loop (A-loop); other site 246197001536 PilZ domain; Region: PilZ; cl01260 246197001537 DNA ligase; Provisional; Region: PRK09125 246197001538 Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896 246197001539 DNA binding site [nucleotide binding] 246197001540 active site 246197001541 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041 246197001542 DNA binding site [nucleotide binding] 246197001543 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 246197001544 AAA domain; Region: AAA_33; pfam13671 246197001545 ATP-binding site [chemical binding]; other site 246197001546 Gluconate-6-phosphate binding site [chemical binding]; other site 246197001547 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 246197001548 active site clefts [active] 246197001549 zinc binding site [ion binding]; other site 246197001550 dimer interface [polypeptide binding]; other site 246197001551 dihydroxyacetone kinase; Provisional; Region: PRK14479 246197001552 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 246197001553 DAK2 domain; Region: Dak2; pfam02734 246197001554 CBS domain; Region: CBS; pfam00571 246197001555 Protein of unknown function, DUF481; Region: DUF481; pfam04338 246197001556 B3/4 domain; Region: B3_4; pfam03483 246197001557 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 246197001558 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 246197001559 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246197001560 Walker A/P-loop; other site 246197001561 ATP binding site [chemical binding]; other site 246197001562 Q-loop/lid; other site 246197001563 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 246197001564 ABC transporter signature motif; other site 246197001565 Walker B; other site 246197001566 D-loop; other site 246197001567 ABC transporter; Region: ABC_tran_2; pfam12848 246197001568 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 246197001569 Bacterial PH domain; Region: DUF304; pfam03703 246197001570 Bacterial PH domain; Region: DUF304; pfam03703 246197001571 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 246197001572 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 246197001573 NAD(P) binding site [chemical binding]; other site 246197001574 catalytic residues [active] 246197001575 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 246197001576 Pseudomonas putida Aldehyde dehydrogenase AlkH-like; Region: ALDH_AlkH-like; cd07134 246197001577 NAD(P) binding site [chemical binding]; other site 246197001578 catalytic residues [active] 246197001579 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246197001580 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cd00138 246197001581 PLD-like domain; Region: PLDc_2; pfam13091 246197001582 putative active site [active] 246197001583 catalytic site [active] 246197001584 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 246197001585 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246197001586 Walker A/P-loop; other site 246197001587 ATP binding site [chemical binding]; other site 246197001588 Q-loop/lid; other site 246197001589 ABC transporter signature motif; other site 246197001590 Walker B; other site 246197001591 H-loop/switch region; other site 246197001592 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 246197001593 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246197001594 Fatty acid desaturase; Region: FA_desaturase; pfam00487 246197001595 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cd01060 246197001596 putative di-iron ligands [ion binding]; other site 246197001597 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 246197001598 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246197001599 non-specific DNA binding site [nucleotide binding]; other site 246197001600 salt bridge; other site 246197001601 sequence-specific DNA binding site [nucleotide binding]; other site 246197001602 Afadin- and alpha -actinin-Binding; Region: ADIP; pfam11559 246197001603 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 246197001604 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 246197001605 P-loop; other site 246197001606 Magnesium ion binding site [ion binding]; other site 246197001607 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 246197001608 Magnesium ion binding site [ion binding]; other site 246197001609 Peptidase family M48; Region: Peptidase_M48; cl12018 246197001610 SH3 domain protein [Signal transduction mechanisms]; Region: COG3103 246197001611 CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080 246197001612 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 246197001613 cyclase homology domain; Region: CHD; cd07302 246197001614 nucleotidyl binding site; other site 246197001615 metal binding site [ion binding]; metal-binding site 246197001616 dimer interface [polypeptide binding]; other site 246197001617 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 246197001618 TspO/MBR family; Region: TspO_MBR; pfam03073 246197001619 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246197001620 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 246197001621 putative active site [active] 246197001622 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 246197001623 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197001624 dimer interface [polypeptide binding]; other site 246197001625 phosphorylation site [posttranslational modification] 246197001626 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197001627 ATP binding site [chemical binding]; other site 246197001628 Mg2+ binding site [ion binding]; other site 246197001629 G-X-G motif; other site 246197001630 Peptidase family M1; Region: Peptidase_M1; pfam01433 246197001631 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 246197001632 Zn binding site [ion binding]; other site 246197001633 HEAT repeats; Region: HEAT_2; pfam13646 246197001634 HEAT repeats; Region: HEAT_2; pfam13646 246197001635 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 246197001636 HSP70 interaction site [polypeptide binding]; other site 246197001637 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 246197001638 putative catalytic site [active] 246197001639 putative phosphate binding site [ion binding]; other site 246197001640 putative metal binding site [ion binding]; other site 246197001641 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 246197001642 Actin-Fragmin Kinase (AFK); catalytic domain. The AFK catalytic domain is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, aminoglycoside...; Region: AFK; cl07713 246197001643 ATP binding site [chemical binding]; other site 246197001644 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 246197001645 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 246197001646 catalytic triad [active] 246197001647 putative active site [active] 246197001648 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 246197001649 MarR family; Region: MarR; pfam01047 246197001650 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 246197001651 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 246197001652 DNA double-strand break repair and V(D)J recombination protein XRCC4; Region: XRCC4; pfam06632 246197001653 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 246197001654 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 246197001655 active site 246197001656 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 246197001657 ribonuclease Z; Region: RNase_Z; TIGR02651 246197001658 Uncharacterized conserved protein (DUF2293); Region: DUF2293; pfam10056 246197001659 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246197001660 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246197001661 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 246197001662 HlyD family secretion protein; Region: HlyD_3; pfam13437 246197001663 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 246197001664 Myxococcales-restricted protein, TIGR02265 family; Region: Mxa_TIGR02265 246197001665 Protein of unknown function DUF99; Region: DUF99; pfam01949 246197001666 hypothetical protein; Provisional; Region: PRK00766 246197001667 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 246197001668 DNA-binding site [nucleotide binding]; DNA binding site 246197001669 RNA-binding motif; other site 246197001670 Predicted transcriptional regulator containing an HTH domain fused to a Zn-ribbon [Transcription]; Region: COG3357 246197001671 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_8; cd08901 246197001672 putative hydrophobic ligand binding site [chemical binding]; other site 246197001673 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 246197001674 putative hydrophobic ligand binding site [chemical binding]; other site 246197001675 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 246197001676 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 246197001677 active site 246197001678 catalytic tetrad [active] 246197001679 Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279 246197001680 active site 246197001681 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 246197001682 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 246197001683 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246197001684 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 246197001685 Thiopurine S-methyltransferase (TPMT); Region: TPMT; pfam05724 246197001686 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197001687 S-adenosylmethionine binding site [chemical binding]; other site 246197001688 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246197001689 Cytochrome P450; Region: p450; pfam00067 246197001690 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 246197001691 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 246197001692 Walker A/P-loop; other site 246197001693 ATP binding site [chemical binding]; other site 246197001694 Q-loop/lid; other site 246197001695 ABC transporter signature motif; other site 246197001696 Walker B; other site 246197001697 D-loop; other site 246197001698 H-loop/switch region; other site 246197001699 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 246197001700 ABC-ATPase subunit interface; other site 246197001701 dimer interface [polypeptide binding]; other site 246197001702 putative PBP binding regions; other site 246197001703 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 246197001704 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 246197001705 ABC-ATPase subunit interface; other site 246197001706 dimer interface [polypeptide binding]; other site 246197001707 putative PBP binding regions; other site 246197001708 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 246197001709 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 246197001710 putative ligand binding residues [chemical binding]; other site 246197001711 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 246197001712 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 246197001713 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 246197001714 B12 binding site [chemical binding]; other site 246197001715 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246197001716 Radical SAM superfamily; Region: Radical_SAM; pfam04055 246197001717 FeS/SAM binding site; other site 246197001718 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 246197001719 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 246197001720 FtsX-like permease family; Region: FtsX; pfam02687 246197001721 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 246197001722 FtsX-like permease family; Region: FtsX; pfam02687 246197001723 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 246197001724 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 246197001725 active site 246197001726 catalytic tetrad [active] 246197001727 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 246197001728 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 246197001729 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 246197001730 Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031 246197001731 Predicted membrane protein [Function unknown]; Region: COG1289 246197001732 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 246197001733 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 246197001734 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246197001735 PAS fold; Region: PAS_3; pfam08447 246197001736 putative active site [active] 246197001737 heme pocket [chemical binding]; other site 246197001738 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 246197001739 PAS domain; Region: PAS; smart00091 246197001740 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197001741 ATP binding site [chemical binding]; other site 246197001742 Mg2+ binding site [ion binding]; other site 246197001743 G-X-G motif; other site 246197001744 Helix-turn-helix domain; Region: HTH_18; pfam12833 246197001745 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246197001746 Protein of unknown function (DUF3703); Region: DUF3703; pfam12487 246197001747 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 246197001748 Walker A motif; other site 246197001749 ATP binding site [chemical binding]; other site 246197001750 Walker B motif; other site 246197001751 KaiC; Region: KaiC; pfam06745 246197001752 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 246197001753 ATP binding site [chemical binding]; other site 246197001754 Walker A motif; other site 246197001755 Walker B motif; other site 246197001756 Response regulator receiver domain; Region: Response_reg; pfam00072 246197001757 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197001758 active site 246197001759 phosphorylation site [posttranslational modification] 246197001760 intermolecular recognition site; other site 246197001761 dimerization interface [polypeptide binding]; other site 246197001762 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 246197001763 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246197001764 dimerization interface [polypeptide binding]; other site 246197001765 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246197001766 dimerization interface [polypeptide binding]; other site 246197001767 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246197001768 dimerization interface [polypeptide binding]; other site 246197001769 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 246197001770 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246197001771 dimerization interface [polypeptide binding]; other site 246197001772 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246197001773 dimerization interface [polypeptide binding]; other site 246197001774 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246197001775 dimerization interface [polypeptide binding]; other site 246197001776 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246197001777 dimerization interface [polypeptide binding]; other site 246197001778 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 246197001779 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246197001780 dimerization interface [polypeptide binding]; other site 246197001781 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246197001782 dimerization interface [polypeptide binding]; other site 246197001783 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 246197001784 GAF domain; Region: GAF; pfam01590 246197001785 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197001786 dimer interface [polypeptide binding]; other site 246197001787 phosphorylation site [posttranslational modification] 246197001788 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197001789 ATP binding site [chemical binding]; other site 246197001790 Mg2+ binding site [ion binding]; other site 246197001791 G-X-G motif; other site 246197001792 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 246197001793 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246197001794 active site 246197001795 phosphorylation site [posttranslational modification] 246197001796 intermolecular recognition site; other site 246197001797 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 246197001798 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197001799 active site 246197001800 phosphorylation site [posttranslational modification] 246197001801 intermolecular recognition site; other site 246197001802 dimerization interface [polypeptide binding]; other site 246197001803 Response regulator receiver domain; Region: Response_reg; pfam00072 246197001804 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197001805 active site 246197001806 phosphorylation site [posttranslational modification] 246197001807 intermolecular recognition site; other site 246197001808 dimerization interface [polypeptide binding]; other site 246197001809 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 246197001810 CheB methylesterase; Region: CheB_methylest; pfam01339 246197001811 Response regulator receiver domain; Region: Response_reg; pfam00072 246197001812 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197001813 active site 246197001814 phosphorylation site [posttranslational modification] 246197001815 intermolecular recognition site; other site 246197001816 dimerization interface [polypeptide binding]; other site 246197001817 GAF domain; Region: GAF; pfam01590 246197001818 GAF domain; Region: GAF; pfam01590 246197001819 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 246197001820 GAF domain; Region: GAF; pfam01590 246197001821 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197001822 dimer interface [polypeptide binding]; other site 246197001823 phosphorylation site [posttranslational modification] 246197001824 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 246197001825 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197001826 ATP binding site [chemical binding]; other site 246197001827 Mg2+ binding site [ion binding]; other site 246197001828 G-X-G motif; other site 246197001829 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 246197001830 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 246197001831 Walker A/P-loop; other site 246197001832 ATP binding site [chemical binding]; other site 246197001833 Q-loop/lid; other site 246197001834 ABC transporter signature motif; other site 246197001835 Walker B; other site 246197001836 D-loop; other site 246197001837 H-loop/switch region; other site 246197001838 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 246197001839 ABC-2 type transporter; Region: ABC2_membrane; cl17235 246197001840 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246197001841 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 246197001842 active site 246197001843 ATP binding site [chemical binding]; other site 246197001844 substrate binding site [chemical binding]; other site 246197001845 activation loop (A-loop); other site 246197001846 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 246197001847 ABC1 family; Region: ABC1; pfam03109 246197001848 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 246197001849 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197001850 active site 246197001851 phosphorylation site [posttranslational modification] 246197001852 intermolecular recognition site; other site 246197001853 dimerization interface [polypeptide binding]; other site 246197001854 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 246197001855 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 246197001856 O-methyltransferase; Region: Methyltransf_2; pfam00891 246197001857 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 246197001858 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 246197001859 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197001860 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 246197001861 active site 246197001862 phosphorylation site [posttranslational modification] 246197001863 intermolecular recognition site; other site 246197001864 dimerization interface [polypeptide binding]; other site 246197001865 PAS fold; Region: PAS_4; pfam08448 246197001866 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197001867 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197001868 dimer interface [polypeptide binding]; other site 246197001869 phosphorylation site [posttranslational modification] 246197001870 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197001871 ATP binding site [chemical binding]; other site 246197001872 Mg2+ binding site [ion binding]; other site 246197001873 G-X-G motif; other site 246197001874 Response regulator receiver domain; Region: Response_reg; pfam00072 246197001875 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197001876 active site 246197001877 phosphorylation site [posttranslational modification] 246197001878 intermolecular recognition site; other site 246197001879 dimerization interface [polypeptide binding]; other site 246197001880 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 246197001881 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197001882 active site 246197001883 phosphorylation site [posttranslational modification] 246197001884 intermolecular recognition site; other site 246197001885 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 246197001886 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197001887 active site 246197001888 phosphorylation site [posttranslational modification] 246197001889 intermolecular recognition site; other site 246197001890 dimerization interface [polypeptide binding]; other site 246197001891 Uncharacterized conserved protein [Function unknown]; Region: COG3287 246197001892 FIST N domain; Region: FIST; pfam08495 246197001893 FIST C domain; Region: FIST_C; pfam10442 246197001894 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 246197001895 heme-binding residues [chemical binding]; other site 246197001896 PAS domain S-box; Region: sensory_box; TIGR00229 246197001897 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246197001898 putative active site [active] 246197001899 heme pocket [chemical binding]; other site 246197001900 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 246197001901 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 246197001902 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197001903 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 246197001904 dimer interface [polypeptide binding]; other site 246197001905 phosphorylation site [posttranslational modification] 246197001906 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197001907 ATP binding site [chemical binding]; other site 246197001908 Mg2+ binding site [ion binding]; other site 246197001909 G-X-G motif; other site 246197001910 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246197001911 ATP binding site [chemical binding]; other site 246197001912 putative Mg++ binding site [ion binding]; other site 246197001913 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246197001914 nucleotide binding region [chemical binding]; other site 246197001915 ATP-binding site [chemical binding]; other site 246197001916 RNA polymerase recycling family C-terminal; Region: RapA_C; pfam12137 246197001917 TadE-like protein; Region: TadE; pfam07811 246197001918 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 246197001919 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 246197001920 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246197001921 Walker A/P-loop; other site 246197001922 ATP binding site [chemical binding]; other site 246197001923 Q-loop/lid; other site 246197001924 ABC transporter signature motif; other site 246197001925 Walker B; other site 246197001926 D-loop; other site 246197001927 H-loop/switch region; other site 246197001928 chaperone protein DnaJ; Provisional; Region: PRK10767 246197001929 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 246197001930 HSP70 interaction site [polypeptide binding]; other site 246197001931 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 246197001932 substrate binding site [polypeptide binding]; other site 246197001933 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 246197001934 Zn binding sites [ion binding]; other site 246197001935 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 246197001936 dimer interface [polypeptide binding]; other site 246197001937 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 246197001938 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 246197001939 putative ligand binding site [chemical binding]; other site 246197001940 FOG: WD40 repeat [General function prediction only]; Region: COG2319 246197001941 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 246197001942 structural tetrad; other site 246197001943 Aspartyl protease; Region: Asp_protease_2; pfam13650 246197001944 inhibitor binding site; inhibition site 246197001945 catalytic motif [active] 246197001946 Catalytic residue [active] 246197001947 Active site flap [active] 246197001948 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 246197001949 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 246197001950 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 246197001951 FAD binding pocket [chemical binding]; other site 246197001952 conserved FAD binding motif [chemical binding]; other site 246197001953 phosphate binding motif [ion binding]; other site 246197001954 beta-alpha-beta structure motif; other site 246197001955 NAD binding pocket [chemical binding]; other site 246197001956 Transglycosylase; Region: Transgly; cl17702 246197001957 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197001958 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197001959 active site 246197001960 ATP binding site [chemical binding]; other site 246197001961 substrate binding site [chemical binding]; other site 246197001962 activation loop (A-loop); other site 246197001963 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 246197001964 Type II/IV secretion system protein; Region: T2SE; pfam00437 246197001965 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 246197001966 ATP binding site [chemical binding]; other site 246197001967 Walker A motif; other site 246197001968 hexamer interface [polypeptide binding]; other site 246197001969 Walker B motif; other site 246197001970 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 246197001971 ligand binding site [chemical binding]; other site 246197001972 active site 246197001973 UGI interface [polypeptide binding]; other site 246197001974 catalytic site [active] 246197001975 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 246197001976 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 246197001977 active site 2 [active] 246197001978 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 246197001979 active site 2 [active] 246197001980 active site 1 [active] 246197001981 Response regulator receiver domain; Region: Response_reg; pfam00072 246197001982 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197001983 active site 246197001984 phosphorylation site [posttranslational modification] 246197001985 intermolecular recognition site; other site 246197001986 dimerization interface [polypeptide binding]; other site 246197001987 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 246197001988 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 246197001989 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 246197001990 active site 246197001991 TPR repeat; Region: TPR_11; pfam13414 246197001992 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197001993 TPR motif; other site 246197001994 DNA gyrase subunit A; Validated; Region: PRK05560 246197001995 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 246197001996 CAP-like domain; other site 246197001997 active site 246197001998 primary dimer interface [polypeptide binding]; other site 246197001999 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 246197002000 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 246197002001 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 246197002002 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 246197002003 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 246197002004 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 246197002005 Protein of unknown function (DUF2379); Region: DUF2379; pfam09543 246197002006 pfkB-type carbohydrate kinase family protein; Region: PLN02630 246197002007 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 246197002008 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 246197002009 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 246197002010 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 246197002011 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246197002012 dimer interface [polypeptide binding]; other site 246197002013 conserved gate region; other site 246197002014 putative PBP binding loops; other site 246197002015 ABC-ATPase subunit interface; other site 246197002016 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246197002017 dimer interface [polypeptide binding]; other site 246197002018 conserved gate region; other site 246197002019 putative PBP binding loops; other site 246197002020 ABC-ATPase subunit interface; other site 246197002021 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 246197002022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246197002023 Walker A/P-loop; other site 246197002024 ATP binding site [chemical binding]; other site 246197002025 Q-loop/lid; other site 246197002026 ABC transporter signature motif; other site 246197002027 Walker B; other site 246197002028 D-loop; other site 246197002029 H-loop/switch region; other site 246197002030 TOBE domain; Region: TOBE_2; pfam08402 246197002031 Uncharacterized conserved protein [Function unknown]; Region: COG3339 246197002032 short chain dehydrogenase; Validated; Region: PRK06182 246197002033 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 246197002034 NADP binding site [chemical binding]; other site 246197002035 active site 246197002036 steroid binding site; other site 246197002037 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 246197002038 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 246197002039 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 246197002040 metal ion-dependent adhesion site (MIDAS); other site 246197002041 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 246197002042 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 246197002043 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 246197002044 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 246197002045 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 246197002046 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 246197002047 dimer interface [polypeptide binding]; other site 246197002048 active site residues [active] 246197002049 NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957 246197002050 Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose; Region: GT1_Trehalose_phosphorylase; cd03792 246197002051 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246197002052 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 246197002053 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246197002054 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 246197002055 putative dimerization interface [polypeptide binding]; other site 246197002056 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246197002057 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 246197002058 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 246197002059 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 246197002060 nucleotide binding site/active site [active] 246197002061 HIT family signature motif; other site 246197002062 catalytic residue [active] 246197002063 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b3; cd09205 246197002064 PLD-like domain; Region: PLDc_2; pfam13091 246197002065 putative homodimer interface [polypeptide binding]; other site 246197002066 putative active site [active] 246197002067 catalytic site [active] 246197002068 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246197002069 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 246197002070 putative Mg++ binding site [ion binding]; other site 246197002071 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246197002072 nucleotide binding region [chemical binding]; other site 246197002073 ATP-binding site [chemical binding]; other site 246197002074 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 246197002075 Catalytic site [active] 246197002076 Putative catalytic domain of uncharacterized hypothetical proteins with one or two copies of the HKD motif; Region: PLDc_unchar6; cd09176 246197002077 PLD-like domain; Region: PLDc_2; pfam13091 246197002078 putative homodimer interface [polypeptide binding]; other site 246197002079 putative active site [active] 246197002080 catalytic site [active] 246197002081 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 246197002082 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 246197002083 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 246197002084 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 246197002085 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 246197002086 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 246197002087 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 246197002088 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 246197002089 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 246197002090 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246197002091 active site 246197002092 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 246197002093 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197002094 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197002095 dimer interface [polypeptide binding]; other site 246197002096 phosphorylation site [posttranslational modification] 246197002097 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197002098 binding surface 246197002099 TPR motif; other site 246197002100 Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279 246197002101 active site 246197002102 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 246197002103 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 246197002104 Membrane transport protein; Region: Mem_trans; cl09117 246197002105 MG2 domain; Region: A2M_N; pfam01835 246197002106 Alpha-2-macroglobulin family; Region: A2M; pfam00207 246197002107 TRAPP trafficking subunit Trs65; Region: Trs65; pfam12735 246197002108 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 246197002109 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 246197002110 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246197002111 short chain dehydrogenase; Provisional; Region: PRK06181 246197002112 NAD(P) binding site [chemical binding]; other site 246197002113 active site 246197002114 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 246197002115 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 246197002116 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 246197002117 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 246197002118 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 246197002119 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 246197002120 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 246197002121 Cna protein B-type domain; Region: Cna_B_2; pfam13715 246197002122 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 246197002123 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 246197002124 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 246197002125 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246197002126 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 246197002127 SnoaL-like domain; Region: SnoaL_3; pfam13474 246197002128 Erythromycin esterase; Region: Erythro_esteras; pfam05139 246197002129 M6 family metalloprotease domain; Region: M6dom_TIGR03296 246197002130 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 246197002131 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246197002132 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246197002133 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 246197002134 PilZ domain; Region: PilZ; pfam07238 246197002135 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 246197002136 active site 246197002137 cosubstrate binding site; other site 246197002138 substrate binding site [chemical binding]; other site 246197002139 catalytic site [active] 246197002140 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 246197002141 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 246197002142 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 246197002143 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 246197002144 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 246197002145 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 246197002146 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 246197002147 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246197002148 catalytic residue [active] 246197002149 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 246197002150 2-enoyl thioester reductase-like; Region: ETR_like; cd05282 246197002151 NADP binding site [chemical binding]; other site 246197002152 dimer interface [polypeptide binding]; other site 246197002153 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 246197002154 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 246197002155 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 246197002156 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 246197002157 molybdopterin cofactor binding site; other site 246197002158 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 246197002159 putative molybdopterin cofactor binding site; other site 246197002160 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 246197002161 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 246197002162 dimer interface [polypeptide binding]; other site 246197002163 active site 246197002164 CoA binding pocket [chemical binding]; other site 246197002165 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 246197002166 ligand binding site [chemical binding]; other site 246197002167 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 246197002168 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 246197002169 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197002170 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 246197002171 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 246197002172 nucleotide binding site [chemical binding]; other site 246197002173 putative NEF/HSP70 interaction site [polypeptide binding]; other site 246197002174 SBD interface [polypeptide binding]; other site 246197002175 Protein of unknown function (DUF2490); Region: DUF2490; pfam10677 246197002176 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 246197002177 Inorganic pyrophosphatase; Region: Pyrophosphatase; pfam00719 246197002178 dimer interface [polypeptide binding]; other site 246197002179 substrate binding site [chemical binding]; other site 246197002180 metal binding sites [ion binding]; metal-binding site 246197002181 Uncharacterized conserved protein [Function unknown]; Region: COG0397 246197002182 hypothetical protein; Validated; Region: PRK00029 246197002183 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 246197002184 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 246197002185 C-terminal domain interface [polypeptide binding]; other site 246197002186 GSH binding site (G-site) [chemical binding]; other site 246197002187 dimer interface [polypeptide binding]; other site 246197002188 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 246197002189 N-terminal domain interface [polypeptide binding]; other site 246197002190 dimer interface [polypeptide binding]; other site 246197002191 substrate binding pocket (H-site) [chemical binding]; other site 246197002192 short chain dehydrogenase; Provisional; Region: PRK06197 246197002193 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 246197002194 putative NAD(P) binding site [chemical binding]; other site 246197002195 active site 246197002196 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 246197002197 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 246197002198 dimerization interface [polypeptide binding]; other site 246197002199 DPS ferroxidase diiron center [ion binding]; other site 246197002200 ion pore; other site 246197002201 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 246197002202 CoenzymeA binding site [chemical binding]; other site 246197002203 subunit interaction site [polypeptide binding]; other site 246197002204 PHB binding site; other site 246197002205 Gram-negative bacterial tonB protein; Region: TonB; cl10048 246197002206 PGAP1-like protein; Region: PGAP1; pfam07819 246197002207 Peptidase S46; Region: Peptidase_S46; pfam10459 246197002208 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 246197002209 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197002210 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197002211 active site 246197002212 ATP binding site [chemical binding]; other site 246197002213 substrate binding site [chemical binding]; other site 246197002214 activation loop (A-loop); other site 246197002215 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 246197002216 cyclase homology domain; Region: CHD; cd07302 246197002217 nucleotidyl binding site; other site 246197002218 metal binding site [ion binding]; metal-binding site 246197002219 dimer interface [polypeptide binding]; other site 246197002220 GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043 246197002221 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 246197002222 putative C-terminal domain interface [polypeptide binding]; other site 246197002223 putative GSH binding site (G-site) [chemical binding]; other site 246197002224 putative dimer interface [polypeptide binding]; other site 246197002225 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 246197002226 putative substrate binding pocket (H-site) [chemical binding]; other site 246197002227 putative N-terminal domain interface [polypeptide binding]; other site 246197002228 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 246197002229 active site 246197002230 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 246197002231 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 246197002232 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246197002233 motif II; other site 246197002234 HAMP domain; Region: HAMP; pfam00672 246197002235 dimerization interface [polypeptide binding]; other site 246197002236 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 246197002237 dimer interface [polypeptide binding]; other site 246197002238 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 246197002239 putative CheW interface [polypeptide binding]; other site 246197002240 Protein required for attachment to host cells; Region: Host_attach; pfam10116 246197002241 Stigma-specific protein, Stig1; Region: Stig1; pfam04885 246197002242 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246197002243 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197002244 active site 246197002245 ATP binding site [chemical binding]; other site 246197002246 substrate binding site [chemical binding]; other site 246197002247 activation loop (A-loop); other site 246197002248 PEGA domain; Region: PEGA; pfam08308 246197002249 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 246197002250 phosphopeptide binding site; other site 246197002251 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 246197002252 glycogen binding site [chemical binding]; other site 246197002253 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 246197002254 Putative esterase; Region: Esterase; pfam00756 246197002255 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 246197002256 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 246197002257 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 246197002258 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 246197002259 Amidohydrolase; Region: Amidohydro_4; pfam13147 246197002260 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246197002261 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 246197002262 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 246197002263 generic binding surface I; other site 246197002264 generic binding surface II; other site 246197002265 Lamin Tail Domain; Region: LTD; pfam00932 246197002266 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246197002267 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246197002268 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 246197002269 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 246197002270 putative active site [active] 246197002271 putative metal binding site [ion binding]; other site 246197002272 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 246197002273 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 246197002274 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 246197002275 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 246197002276 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 246197002277 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 246197002278 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 246197002279 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 246197002280 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 246197002281 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 246197002282 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 246197002283 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 246197002284 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 246197002285 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 246197002286 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 246197002287 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 246197002288 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 246197002289 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 246197002290 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 246197002291 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 246197002292 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 246197002293 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 246197002294 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 246197002295 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 246197002296 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 246197002297 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 246197002298 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 246197002299 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 246197002300 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 246197002301 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 246197002302 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 246197002303 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 246197002304 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 246197002305 Putative esterase; Region: Esterase; pfam00756 246197002306 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 246197002307 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 246197002308 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 246197002309 putative NAD(P) binding site [chemical binding]; other site 246197002310 putative active site [active] 246197002311 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 246197002312 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 246197002313 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 246197002314 substrate binding pocket [chemical binding]; other site 246197002315 chain length determination region; other site 246197002316 substrate-Mg2+ binding site; other site 246197002317 catalytic residues [active] 246197002318 aspartate-rich region 1; other site 246197002319 active site lid residues [active] 246197002320 aspartate-rich region 2; other site 246197002321 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 246197002322 phytoene desaturase; Region: crtI_fam; TIGR02734 246197002323 RAB proteins geranylgeranyltransferase component A (RAB escort protein) [Posttranslational modification, protein turnover, chaperones]; Region: MRS6; cl17678 246197002324 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 246197002325 catalytic residues [active] 246197002326 substrate binding pocket [chemical binding]; other site 246197002327 aspartate-rich region 2; other site 246197002328 substrate-Mg2+ binding site; other site 246197002329 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 246197002330 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 246197002331 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 246197002332 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 246197002333 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 246197002334 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 246197002335 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551 246197002336 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 246197002337 putative acyl-acceptor binding pocket; other site 246197002338 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 246197002339 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 246197002340 DNA binding residues [nucleotide binding] 246197002341 B12 binding domain; Region: B12-binding_2; pfam02607 246197002342 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065 246197002343 B12 binding site [chemical binding]; other site 246197002344 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 246197002345 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 246197002346 DNA binding residues [nucleotide binding] 246197002347 B12 binding domain; Region: B12-binding_2; pfam02607 246197002348 B12 binding domain; Region: B12-binding; pfam02310 246197002349 B12 binding site [chemical binding]; other site 246197002350 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 246197002351 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197002352 active site 246197002353 ATP binding site [chemical binding]; other site 246197002354 substrate binding site [chemical binding]; other site 246197002355 activation loop (A-loop); other site 246197002356 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246197002357 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246197002358 AAA ATPase domain; Region: AAA_16; pfam13191 246197002359 PEGA domain; Region: PEGA; pfam08308 246197002360 Uncharacterized conserved protein [Function unknown]; Region: COG1262 246197002361 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 246197002362 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 246197002363 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246197002364 phosphopeptide binding site; other site 246197002365 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197002366 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 246197002367 Walker A motif; other site 246197002368 ATP binding site [chemical binding]; other site 246197002369 Walker B motif; other site 246197002370 arginine finger; other site 246197002371 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 246197002372 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 246197002373 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 246197002374 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 246197002375 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 246197002376 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 246197002377 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246197002378 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 246197002379 putative NAD(P) binding site [chemical binding]; other site 246197002380 putative active site [active] 246197002381 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 246197002382 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 246197002383 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 246197002384 kynureninase; Region: kynureninase; TIGR01814 246197002385 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 246197002386 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246197002387 catalytic residue [active] 246197002388 active site 246197002389 Amidohydrolase; Region: Amidohydro_2; pfam04909 246197002390 3-hydroxyanthranilate 3,4-dioxygenase; Provisional; Region: PRK13264 246197002391 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 246197002392 homotrimer interaction site [polypeptide binding]; other site 246197002393 putative active site [active] 246197002394 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 246197002395 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 246197002396 NAD binding site [chemical binding]; other site 246197002397 catalytic residues [active] 246197002398 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 246197002399 classical (c) SDRs; Region: SDR_c; cd05233 246197002400 NAD(P) binding site [chemical binding]; other site 246197002401 active site 246197002402 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 246197002403 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 246197002404 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 246197002405 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 246197002406 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197002407 dimer interface [polypeptide binding]; other site 246197002408 phosphorylation site [posttranslational modification] 246197002409 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197002410 ATP binding site [chemical binding]; other site 246197002411 Mg2+ binding site [ion binding]; other site 246197002412 G-X-G motif; other site 246197002413 GLTT repeat (6 copies); Region: GLTT; pfam01744 246197002414 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197002415 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197002416 active site 246197002417 ATP binding site [chemical binding]; other site 246197002418 substrate binding site [chemical binding]; other site 246197002419 activation loop (A-loop); other site 246197002420 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246197002421 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 246197002422 phosphopeptide binding site; other site 246197002423 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246197002424 PAS fold; Region: PAS_3; pfam08447 246197002425 putative active site [active] 246197002426 heme pocket [chemical binding]; other site 246197002427 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 246197002428 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246197002429 putative active site [active] 246197002430 heme pocket [chemical binding]; other site 246197002431 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197002432 dimer interface [polypeptide binding]; other site 246197002433 phosphorylation site [posttranslational modification] 246197002434 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197002435 ATP binding site [chemical binding]; other site 246197002436 Mg2+ binding site [ion binding]; other site 246197002437 G-X-G motif; other site 246197002438 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 246197002439 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197002440 active site 246197002441 phosphorylation site [posttranslational modification] 246197002442 intermolecular recognition site; other site 246197002443 dimerization interface [polypeptide binding]; other site 246197002444 oligopeptide transporter, OPT superfamily; Region: OPT_sfam; TIGR00728 246197002445 OPT oligopeptide transporter protein; Region: OPT; pfam03169 246197002446 Protein kinase domain; Region: Pkinase; pfam00069 246197002447 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197002448 active site 246197002449 ATP binding site [chemical binding]; other site 246197002450 substrate binding site [chemical binding]; other site 246197002451 activation loop (A-loop); other site 246197002452 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 246197002453 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 246197002454 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 246197002455 protein binding site [polypeptide binding]; other site 246197002456 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 246197002457 protein binding site [polypeptide binding]; other site 246197002458 Response regulator receiver domain; Region: Response_reg; pfam00072 246197002459 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197002460 active site 246197002461 phosphorylation site [posttranslational modification] 246197002462 intermolecular recognition site; other site 246197002463 dimerization interface [polypeptide binding]; other site 246197002464 Glutamine cyclotransferase; Region: Glu_cyclase_2; pfam05096 246197002465 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 246197002466 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197002467 active site 246197002468 phosphorylation site [posttranslational modification] 246197002469 intermolecular recognition site; other site 246197002470 dimerization interface [polypeptide binding]; other site 246197002471 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197002472 Walker A motif; other site 246197002473 ATP binding site [chemical binding]; other site 246197002474 Walker B motif; other site 246197002475 arginine finger; other site 246197002476 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 246197002477 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197002478 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246197002479 dimerization interface [polypeptide binding]; other site 246197002480 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197002481 dimer interface [polypeptide binding]; other site 246197002482 phosphorylation site [posttranslational modification] 246197002483 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197002484 ATP binding site [chemical binding]; other site 246197002485 Mg2+ binding site [ion binding]; other site 246197002486 G-X-G motif; other site 246197002487 conserved hypothetical protein; Region: TIGR02231 246197002488 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 246197002489 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 246197002490 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 246197002491 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 246197002492 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197002493 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 246197002494 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 246197002495 nudix motif; other site 246197002496 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 246197002497 MarR family; Region: MarR; pfam01047 246197002498 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 246197002499 MYXO-CTERM domain; Region: MYXO-CTERM; TIGR03901 246197002500 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197002501 binding surface 246197002502 TPR motif; other site 246197002503 TPR repeat; Region: TPR_11; pfam13414 246197002504 CHAT domain; Region: CHAT; cl17868 246197002505 Cupin-like domain; Region: Cupin_8; pfam13621 246197002506 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 246197002507 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246197002508 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 246197002509 DNA binding residues [nucleotide binding] 246197002510 Putative zinc-finger; Region: zf-HC2; pfam13490 246197002511 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 246197002512 binding surface 246197002513 TPR motif; other site 246197002514 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 246197002515 Medium-chain acyl-CoA synthetase (MACS or ACSM); Region: MACS_like; cd05972 246197002516 active site 246197002517 acyl-activating enzyme (AAE) consensus motif; other site 246197002518 putative CoA binding site [chemical binding]; other site 246197002519 AMP binding site [chemical binding]; other site 246197002520 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246197002521 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246197002522 active site 246197002523 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 246197002524 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 246197002525 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 246197002526 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 246197002527 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 246197002528 putative active site [active] 246197002529 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 246197002530 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 246197002531 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 246197002532 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 246197002533 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 246197002534 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 246197002535 putative acyl-acceptor binding pocket; other site 246197002536 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 246197002537 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 246197002538 exonuclease subunit SbcD; Provisional; Region: PRK10966 246197002539 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 246197002540 active site 246197002541 metal binding site [ion binding]; metal-binding site 246197002542 DNA binding site [nucleotide binding] 246197002543 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 246197002544 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246197002545 Walker A/P-loop; other site 246197002546 ATP binding site [chemical binding]; other site 246197002547 Q-loop/lid; other site 246197002548 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246197002549 ABC transporter signature motif; other site 246197002550 Walker B; other site 246197002551 D-loop; other site 246197002552 H-loop/switch region; other site 246197002553 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197002554 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197002555 active site 246197002556 ATP binding site [chemical binding]; other site 246197002557 substrate binding site [chemical binding]; other site 246197002558 activation loop (A-loop); other site 246197002559 Myxococcus xanthus paralogous domain TIGR02266; Region: gmx_TIGR02266 246197002560 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 246197002561 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_4; cd06241 246197002562 putative active site [active] 246197002563 Zn binding site [ion binding]; other site 246197002564 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 246197002565 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 246197002566 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 246197002567 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 246197002568 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246197002569 dimer interface [polypeptide binding]; other site 246197002570 conserved gate region; other site 246197002571 ABC-ATPase subunit interface; other site 246197002572 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 246197002573 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 246197002574 Walker A/P-loop; other site 246197002575 ATP binding site [chemical binding]; other site 246197002576 Q-loop/lid; other site 246197002577 ABC transporter signature motif; other site 246197002578 Walker B; other site 246197002579 D-loop; other site 246197002580 H-loop/switch region; other site 246197002581 NIL domain; Region: NIL; pfam09383 246197002582 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 246197002583 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 246197002584 homodimer interface [polypeptide binding]; other site 246197002585 substrate-cofactor binding pocket; other site 246197002586 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246197002587 catalytic residue [active] 246197002588 cystathionine gamma-synthase; Reviewed; Region: PRK08247 246197002589 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 246197002590 homodimer interface [polypeptide binding]; other site 246197002591 substrate-cofactor binding pocket; other site 246197002592 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246197002593 catalytic residue [active] 246197002594 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 246197002595 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 246197002596 nucleotide binding site [chemical binding]; other site 246197002597 substrate binding site [chemical binding]; other site 246197002598 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 246197002599 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 246197002600 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 246197002601 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 246197002602 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 246197002603 GIY-YIG motif/motif A; other site 246197002604 AZL_007920/MXAN_0976 family protein; Region: AZL_007920_fam; TIGR04052 246197002605 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 246197002606 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 246197002607 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 246197002608 dimer interface [polypeptide binding]; other site 246197002609 YHS domain; Region: YHS; pfam04945 246197002610 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 246197002611 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 246197002612 Soluble P-type ATPase [General function prediction only]; Region: COG4087 246197002613 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 246197002614 dimerization interface [polypeptide binding]; other site 246197002615 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 246197002616 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 246197002617 iron-sulfur cluster [ion binding]; other site 246197002618 [2Fe-2S] cluster binding site [ion binding]; other site 246197002619 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 246197002620 hydrophobic ligand binding site; other site 246197002621 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 246197002622 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 246197002623 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 246197002624 HlyD family secretion protein; Region: HlyD_3; pfam13437 246197002625 Outer membrane efflux protein; Region: OEP; pfam02321 246197002626 Outer membrane efflux protein; Region: OEP; pfam02321 246197002627 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 246197002628 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 246197002629 amidase catalytic site [active] 246197002630 Zn binding residues [ion binding]; other site 246197002631 substrate binding site [chemical binding]; other site 246197002632 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 246197002633 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 246197002634 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 246197002635 HlyD family secretion protein; Region: HlyD_3; pfam13437 246197002636 Outer membrane efflux protein; Region: OEP; pfam02321 246197002637 Outer membrane efflux protein; Region: OEP; pfam02321 246197002638 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 246197002639 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 246197002640 dimer interface [polypeptide binding]; other site 246197002641 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246197002642 catalytic residue [active] 246197002643 Response regulator receiver domain; Region: Response_reg; pfam00072 246197002644 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197002645 active site 246197002646 phosphorylation site [posttranslational modification] 246197002647 intermolecular recognition site; other site 246197002648 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 246197002649 dimerization interface [polypeptide binding]; other site 246197002650 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 246197002651 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197002652 dimer interface [polypeptide binding]; other site 246197002653 phosphorylation site [posttranslational modification] 246197002654 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197002655 ATP binding site [chemical binding]; other site 246197002656 Mg2+ binding site [ion binding]; other site 246197002657 G-X-G motif; other site 246197002658 Myxococcales-restricted protein, TIGR02265 family; Region: Mxa_TIGR02265 246197002659 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 246197002660 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 246197002661 Walker A/P-loop; other site 246197002662 ATP binding site [chemical binding]; other site 246197002663 Q-loop/lid; other site 246197002664 ABC transporter signature motif; other site 246197002665 Walker B; other site 246197002666 D-loop; other site 246197002667 H-loop/switch region; other site 246197002668 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 246197002669 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 246197002670 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246197002671 ATP binding site [chemical binding]; other site 246197002672 putative Mg++ binding site [ion binding]; other site 246197002673 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246197002674 nucleotide binding region [chemical binding]; other site 246197002675 ATP-binding site [chemical binding]; other site 246197002676 DEAD/H associated; Region: DEAD_assoc; pfam08494 246197002677 Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496 246197002678 active site 246197002679 catalytic triad [active] 246197002680 PMG protein; Region: PMG; pfam05287 246197002681 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 246197002682 heme ligand [chemical binding]; other site 246197002683 Protein of unknown function (DUF420); Region: DUF420; pfam04238 246197002684 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 246197002685 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 246197002686 Family description; Region: VCBS; pfam13517 246197002687 Integrin alpha (beta-propellor repeats); Region: Int_alpha; smart00191 246197002688 Uncharacterized conserved protein [Function unknown]; Region: COG4095 246197002689 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 246197002690 dinuclear metal binding motif [ion binding]; other site 246197002691 formiminoglutamate deiminase; Region: hutF; TIGR02022 246197002692 Metallo-dependent hydrolases, subgroup D is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_E; cd01313 246197002693 active site 246197002694 acetylornithine deacetylase (ArgE); Region: AcOrn-deacetyl; TIGR01892 246197002695 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 246197002696 metal binding site [ion binding]; metal-binding site 246197002697 putative dimer interface [polypeptide binding]; other site 246197002698 transcription-repair coupling factor (mfd); Region: mfd; TIGR00580 246197002699 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 246197002700 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246197002701 ATP binding site [chemical binding]; other site 246197002702 putative Mg++ binding site [ion binding]; other site 246197002703 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246197002704 nucleotide binding region [chemical binding]; other site 246197002705 ATP-binding site [chemical binding]; other site 246197002706 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 246197002707 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 246197002708 PAS domain; Region: PAS; smart00091 246197002709 putative active site [active] 246197002710 heme pocket [chemical binding]; other site 246197002711 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197002712 dimer interface [polypeptide binding]; other site 246197002713 phosphorylation site [posttranslational modification] 246197002714 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197002715 ATP binding site [chemical binding]; other site 246197002716 Mg2+ binding site [ion binding]; other site 246197002717 G-X-G motif; other site 246197002718 Cytochrome c; Region: Cytochrom_C; pfam00034 246197002719 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 246197002720 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 246197002721 Tfp pilus assembly protein, tip-associated adhesin PilY1 [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilY1; COG3419 246197002722 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 246197002723 active site 246197002724 Methyltransferase domain; Region: Methyltransf_23; pfam13489 246197002725 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197002726 S-adenosylmethionine binding site [chemical binding]; other site 246197002727 chain length determinant protein EpsF; Region: EpsF; TIGR03017 246197002728 Chain length determinant protein; Region: Wzz; cl15801 246197002729 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 246197002730 Chain length determinant protein; Region: Wzz; cl15801 246197002731 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 246197002732 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 246197002733 Magnesium ion binding site [ion binding]; other site 246197002734 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246197002735 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 246197002736 putative ADP-binding pocket [chemical binding]; other site 246197002737 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246197002738 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 246197002739 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 246197002740 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 246197002741 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246197002742 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 246197002743 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246197002744 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 246197002745 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246197002746 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 246197002747 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246197002748 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 246197002749 Methyltransferase domain; Region: Methyltransf_12; pfam08242 246197002750 S-adenosylmethionine binding site [chemical binding]; other site 246197002751 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 246197002752 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 246197002753 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 246197002754 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 246197002755 Probable Catalytic site; other site 246197002756 metal-binding site 246197002757 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 246197002758 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 246197002759 active site 246197002760 Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075 246197002761 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 246197002762 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 246197002763 Sulfatase; Region: Sulfatase; pfam00884 246197002764 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 246197002765 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246197002766 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 246197002767 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 246197002768 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 246197002769 Mg++ binding site [ion binding]; other site 246197002770 putative catalytic motif [active] 246197002771 substrate binding site [chemical binding]; other site 246197002772 Family description; Region: VCBS; pfam13517 246197002773 Family description; Region: VCBS; pfam13517 246197002774 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 246197002775 Family description; Region: VCBS; pfam13517 246197002776 active site 246197002777 Family description; Region: VCBS; pfam13517 246197002778 Family description; Region: VCBS; pfam13517 246197002779 CARDB; Region: CARDB; pfam07705 246197002780 HYR domain; Region: HYR; pfam02494 246197002781 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 246197002782 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 246197002783 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 246197002784 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 246197002785 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 246197002786 O-Antigen ligase; Region: Wzy_C; pfam04932 246197002787 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197002788 TPR motif; other site 246197002789 binding surface 246197002790 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 246197002791 putative deacylase active site [active] 246197002792 Predicted lipoprotein of unknown function (DUF2380); Region: DUF2380; cl15289 246197002793 Myxococcus xanthus double-CXXCG motif paralogous family; Region: gmx_para_CXXCG; TIGR02264 246197002794 succinylarginine dihydrolase; Provisional; Region: PRK13281 246197002795 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 246197002796 putative acyl-acceptor binding pocket; other site 246197002797 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 246197002798 OstA-like protein; Region: OstA; pfam03968 246197002799 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 246197002800 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 246197002801 Walker A/P-loop; other site 246197002802 ATP binding site [chemical binding]; other site 246197002803 Q-loop/lid; other site 246197002804 ABC transporter signature motif; other site 246197002805 Walker B; other site 246197002806 D-loop; other site 246197002807 H-loop/switch region; other site 246197002808 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 246197002809 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 246197002810 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 246197002811 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 246197002812 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 246197002813 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 246197002814 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 246197002815 30S subunit binding site; other site 246197002816 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 246197002817 active site 246197002818 phosphorylation site [posttranslational modification] 246197002819 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 246197002820 putative active site [active] 246197002821 dimerization interface [polypeptide binding]; other site 246197002822 putative tRNAtyr binding site [nucleotide binding]; other site 246197002823 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 246197002824 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 246197002825 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 246197002826 dimer interface [polypeptide binding]; other site 246197002827 ssDNA binding site [nucleotide binding]; other site 246197002828 tetramer (dimer of dimers) interface [polypeptide binding]; other site 246197002829 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 246197002830 Iron-sulfur protein interface; other site 246197002831 proximal heme binding site [chemical binding]; other site 246197002832 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 246197002833 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 246197002834 dimerization interface [polypeptide binding]; other site 246197002835 domain crossover interface; other site 246197002836 redox-dependent activation switch; other site 246197002837 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 246197002838 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 246197002839 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 246197002840 NAD binding site [chemical binding]; other site 246197002841 Phe binding site; other site 246197002842 Predicted phosphoribosyltransferases [General function prediction only]; Region: COG2236 246197002843 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 246197002844 active site 246197002845 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 246197002846 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 246197002847 G1 box; other site 246197002848 GTP/Mg2+ binding site [chemical binding]; other site 246197002849 G2 box; other site 246197002850 Switch I region; other site 246197002851 G3 box; other site 246197002852 Switch II region; other site 246197002853 G4 box; other site 246197002854 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 246197002855 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 246197002856 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 246197002857 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 246197002858 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246197002859 putative active site [active] 246197002860 heme pocket [chemical binding]; other site 246197002861 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 246197002862 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 246197002863 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197002864 dimer interface [polypeptide binding]; other site 246197002865 phosphorylation site [posttranslational modification] 246197002866 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197002867 ATP binding site [chemical binding]; other site 246197002868 Mg2+ binding site [ion binding]; other site 246197002869 G-X-G motif; other site 246197002870 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 246197002871 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197002872 active site 246197002873 phosphorylation site [posttranslational modification] 246197002874 intermolecular recognition site; other site 246197002875 dimerization interface [polypeptide binding]; other site 246197002876 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197002877 Walker A motif; other site 246197002878 ATP binding site [chemical binding]; other site 246197002879 Walker B motif; other site 246197002880 arginine finger; other site 246197002881 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 246197002882 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246197002883 Coenzyme A binding pocket [chemical binding]; other site 246197002884 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 246197002885 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 246197002886 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 246197002887 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 246197002888 proton-translocating NADH-quinone oxidoreductase, chain L; Region: NDH_I_L; TIGR01974 246197002889 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 246197002890 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 246197002891 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 246197002892 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 246197002893 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 246197002894 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 246197002895 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 246197002896 SLBB domain; Region: SLBB; pfam10531 246197002897 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 246197002898 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 246197002899 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 246197002900 putative dimer interface [polypeptide binding]; other site 246197002901 [2Fe-2S] cluster binding site [ion binding]; other site 246197002902 Myxococcus xanthus paralogous domain TIGR02266; Region: gmx_TIGR02266 246197002903 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 246197002904 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197002905 active site 246197002906 phosphorylation site [posttranslational modification] 246197002907 intermolecular recognition site; other site 246197002908 dimerization interface [polypeptide binding]; other site 246197002909 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197002910 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197002911 active site 246197002912 ATP binding site [chemical binding]; other site 246197002913 substrate binding site [chemical binding]; other site 246197002914 activation loop (A-loop); other site 246197002915 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246197002916 Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716 246197002917 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 246197002918 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 246197002919 phosphoserine phosphatase SerB; Region: serB; TIGR00338 246197002920 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246197002921 motif II; other site 246197002922 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 246197002923 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 246197002924 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 246197002925 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 246197002926 putative dimer interface [polypeptide binding]; other site 246197002927 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 246197002928 DNA binding residues [nucleotide binding] 246197002929 Response regulator receiver domain; Region: Response_reg; pfam00072 246197002930 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197002931 active site 246197002932 phosphorylation site [posttranslational modification] 246197002933 intermolecular recognition site; other site 246197002934 dimerization interface [polypeptide binding]; other site 246197002935 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 246197002936 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 246197002937 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 246197002938 CTP synthetase; Validated; Region: pyrG; PRK05380 246197002939 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 246197002940 Catalytic site [active] 246197002941 active site 246197002942 UTP binding site [chemical binding]; other site 246197002943 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 246197002944 active site 246197002945 putative oxyanion hole; other site 246197002946 catalytic triad [active] 246197002947 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 246197002948 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 246197002949 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 246197002950 Walker A/P-loop; other site 246197002951 ATP binding site [chemical binding]; other site 246197002952 Q-loop/lid; other site 246197002953 ABC transporter signature motif; other site 246197002954 Walker B; other site 246197002955 D-loop; other site 246197002956 H-loop/switch region; other site 246197002957 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 246197002958 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 246197002959 active site 246197002960 catalytic tetrad [active] 246197002961 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 246197002962 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 246197002963 Ligand binding site; other site 246197002964 oligomer interface; other site 246197002965 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 246197002966 active site 246197002967 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 246197002968 homodimer interface [polypeptide binding]; other site 246197002969 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 246197002970 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 246197002971 active site 246197002972 amidophosphoribosyltransferase; Provisional; Region: PRK09123 246197002973 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 246197002974 active site 246197002975 tetramer interface [polypeptide binding]; other site 246197002976 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 246197002977 active site 246197002978 CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985 246197002979 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 246197002980 HSP70 interaction site [polypeptide binding]; other site 246197002981 TPR repeat; Region: TPR_11; pfam13414 246197002982 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197002983 binding surface 246197002984 TPR motif; other site 246197002985 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 246197002986 hypothetical protein; Provisional; Region: PRK10621 246197002987 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 246197002988 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 246197002989 carboxyltransferase (CT) interaction site; other site 246197002990 biotinylation site [posttranslational modification]; other site 246197002991 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 246197002992 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 246197002993 ATP-grasp domain; Region: ATP-grasp_4; cl17255 246197002994 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 246197002995 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 246197002996 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 246197002997 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 246197002998 Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Region: Coq4; cl02093 246197002999 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 246197003000 Peptidase family M50; Region: Peptidase_M50; pfam02163 246197003001 active site 246197003002 putative substrate binding region [chemical binding]; other site 246197003003 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 246197003004 DUSAM domain; Region: TIGR02267 246197003005 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 246197003006 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 246197003007 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 246197003008 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246197003009 catalytic residue [active] 246197003010 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246197003011 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246197003012 homodimer interface [polypeptide binding]; other site 246197003013 catalytic residue [active] 246197003014 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 246197003015 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 246197003016 Walker A/P-loop; other site 246197003017 ATP binding site [chemical binding]; other site 246197003018 Q-loop/lid; other site 246197003019 ABC transporter signature motif; other site 246197003020 Walker B; other site 246197003021 D-loop; other site 246197003022 H-loop/switch region; other site 246197003023 Methyltransferase domain; Region: Methyltransf_31; pfam13847 246197003024 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197003025 S-adenosylmethionine binding site [chemical binding]; other site 246197003026 PRMT5 arginine-N-methyltransferase; Region: PRMT5; cl17640 246197003027 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 246197003028 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 246197003029 Protein of unknown function (DUF1298); Region: DUF1298; pfam06974 246197003030 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 246197003031 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197003032 active site 246197003033 phosphorylation site [posttranslational modification] 246197003034 intermolecular recognition site; other site 246197003035 dimerization interface [polypeptide binding]; other site 246197003036 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197003037 Walker A motif; other site 246197003038 ATP binding site [chemical binding]; other site 246197003039 Walker B motif; other site 246197003040 arginine finger; other site 246197003041 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 246197003042 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197003043 dimer interface [polypeptide binding]; other site 246197003044 phosphorylation site [posttranslational modification] 246197003045 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197003046 ATP binding site [chemical binding]; other site 246197003047 Mg2+ binding site [ion binding]; other site 246197003048 G-X-G motif; other site 246197003049 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 246197003050 HEAT repeats; Region: HEAT_2; pfam13646 246197003051 RDD family; Region: RDD; pfam06271 246197003052 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 246197003053 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 246197003054 cyclase homology domain; Region: CHD; cd07302 246197003055 nucleotidyl binding site; other site 246197003056 metal binding site [ion binding]; metal-binding site 246197003057 dimer interface [polypeptide binding]; other site 246197003058 Protein of unknown function (DUF962); Region: DUF962; cl01879 246197003059 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 246197003060 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 246197003061 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246197003062 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 246197003063 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 246197003064 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197003065 S-adenosylmethionine binding site [chemical binding]; other site 246197003066 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 246197003067 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 246197003068 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 246197003069 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 246197003070 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 246197003071 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 246197003072 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 246197003073 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 246197003074 HemN C-terminal domain; Region: HemN_C; pfam06969 246197003075 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 246197003076 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 246197003077 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197003078 binding surface 246197003079 TPR motif; other site 246197003080 TadE-like protein; Region: TadE; pfam07811 246197003081 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 246197003082 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 246197003083 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 246197003084 putative ligand binding site [chemical binding]; other site 246197003085 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 246197003086 Transcriptional regulator; Region: Rrf2; pfam02082 246197003087 Transcriptional regulator; Region: Rrf2; cl17282 246197003088 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 246197003089 putative ABC transporter; Region: ycf24; CHL00085 246197003090 FeS assembly ATPase SufC; Region: sufC; TIGR01978 246197003091 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 246197003092 Walker A/P-loop; other site 246197003093 ATP binding site [chemical binding]; other site 246197003094 Q-loop/lid; other site 246197003095 ABC transporter signature motif; other site 246197003096 Walker B; other site 246197003097 D-loop; other site 246197003098 H-loop/switch region; other site 246197003099 FeS assembly protein SufD; Region: sufD; TIGR01981 246197003100 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 246197003101 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 246197003102 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 246197003103 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246197003104 catalytic residue [active] 246197003105 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 246197003106 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 246197003107 trimerization site [polypeptide binding]; other site 246197003108 active site 246197003109 probable FeS assembly SUF system protein SufT; Region: FeS_long_SufT; TIGR03406 246197003110 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 246197003111 intracellular protease, PfpI family; Region: PfpI; TIGR01382 246197003112 proposed catalytic triad [active] 246197003113 conserved cys residue [active] 246197003114 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 246197003115 catalytic nucleophile [active] 246197003116 Tetratricopeptide repeat; Region: TPR_16; pfam13432 246197003117 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197003118 TPR motif; other site 246197003119 binding surface 246197003120 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 246197003121 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197003122 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197003123 active site 246197003124 ATP binding site [chemical binding]; other site 246197003125 substrate binding site [chemical binding]; other site 246197003126 activation loop (A-loop); other site 246197003127 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 246197003128 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 246197003129 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197003130 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197003131 dimer interface [polypeptide binding]; other site 246197003132 phosphorylation site [posttranslational modification] 246197003133 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197003134 ATP binding site [chemical binding]; other site 246197003135 Mg2+ binding site [ion binding]; other site 246197003136 G-X-G motif; other site 246197003137 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 246197003138 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197003139 active site 246197003140 phosphorylation site [posttranslational modification] 246197003141 intermolecular recognition site; other site 246197003142 dimerization interface [polypeptide binding]; other site 246197003143 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197003144 Walker A motif; other site 246197003145 ATP binding site [chemical binding]; other site 246197003146 Walker B motif; other site 246197003147 arginine finger; other site 246197003148 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 246197003149 Tellurite resistance protein TerB; Region: TerB; cl17311 246197003150 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 246197003151 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 246197003152 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246197003153 NAD(P) binding site [chemical binding]; other site 246197003154 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 246197003155 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246197003156 active site 246197003157 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 246197003158 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 246197003159 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 246197003160 Serine hydrolase (FSH1); Region: FSH1; pfam03959 246197003161 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 246197003162 active site 246197003163 trigger factor; Region: tig; TIGR00115 246197003164 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 246197003165 PGAP1-like protein; Region: PGAP1; pfam07819 246197003166 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 246197003167 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 246197003168 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 246197003169 spermidine synthase; Provisional; Region: PRK03612 246197003170 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197003171 S-adenosylmethionine binding site [chemical binding]; other site 246197003172 protoporphyrinogen oxidase; Region: proto_IX_ox; TIGR00562 246197003173 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 246197003174 Sulfatase; Region: Sulfatase; pfam00884 246197003175 Surface antigen; Region: Bac_surface_Ag; pfam01103 246197003176 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 246197003177 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197003178 active site 246197003179 phosphorylation site [posttranslational modification] 246197003180 intermolecular recognition site; other site 246197003181 dimerization interface [polypeptide binding]; other site 246197003182 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197003183 Walker A motif; other site 246197003184 ATP binding site [chemical binding]; other site 246197003185 Walker B motif; other site 246197003186 arginine finger; other site 246197003187 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 246197003188 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246197003189 dimerization interface [polypeptide binding]; other site 246197003190 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197003191 dimer interface [polypeptide binding]; other site 246197003192 phosphorylation site [posttranslational modification] 246197003193 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197003194 ATP binding site [chemical binding]; other site 246197003195 Mg2+ binding site [ion binding]; other site 246197003196 G-X-G motif; other site 246197003197 putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional; Region: PRK14501 246197003198 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 246197003199 active site 246197003200 homotetramer interface [polypeptide binding]; other site 246197003201 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 246197003202 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 246197003203 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 246197003204 N-acetyltransferase; Region: Acetyltransf_2; pfam00797 246197003205 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 246197003206 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 246197003207 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 246197003208 Zn binding site [ion binding]; other site 246197003209 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 246197003210 putative active site [active] 246197003211 DNA utilization protein GntX; Provisional; Region: PRK11595 246197003212 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 246197003213 active site 246197003214 Int/Topo IB signature motif; other site 246197003215 catalytic residues [active] 246197003216 DNA binding site [nucleotide binding] 246197003217 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 246197003218 active site 246197003219 catalytic site [active] 246197003220 substrate binding site [chemical binding]; other site 246197003221 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626 246197003222 active site 246197003223 DNA binding site [nucleotide binding] 246197003224 catalytic site [active] 246197003225 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 246197003226 putative Mg++ binding site [ion binding]; other site 246197003227 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 246197003228 nucleotide binding region [chemical binding]; other site 246197003229 ATP-binding site [chemical binding]; other site 246197003230 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 246197003231 DNA methylase; Region: N6_N4_Mtase; pfam01555 246197003232 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 246197003233 Virulence-associated protein E; Region: VirE; pfam05272 246197003234 Uncharacterized conserved protein [Function unknown]; Region: COG5323 246197003235 Terminase-like family; Region: Terminase_6; pfam03237 246197003236 Phage-related protein [Function unknown]; Region: COG4695; cl01923 246197003237 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 246197003238 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cl00315 246197003239 Phage capsid family; Region: Phage_capsid; pfam05065 246197003240 Minor capsid protein; Region: Minor_capsid_1; pfam10665 246197003241 Phage major tail protein 2; Region: Phage_tail_2; cl11463 246197003242 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 246197003243 Interdomain contacts; other site 246197003244 Cytokine receptor motif; other site 246197003245 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 246197003246 protein-splicing catalytic site; other site 246197003247 thioester formation/cholesterol transfer; other site 246197003248 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 246197003249 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 246197003250 Protein of unknown function (DUF2381); Region: DUF2381; pfam09544 246197003251 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197003252 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197003253 active site 246197003254 ATP binding site [chemical binding]; other site 246197003255 substrate binding site [chemical binding]; other site 246197003256 activation loop (A-loop); other site 246197003257 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246197003258 active site 246197003259 ATP binding site [chemical binding]; other site 246197003260 substrate binding site [chemical binding]; other site 246197003261 activation loop (A-loop); other site 246197003262 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 246197003263 phosphoglyceromutase; Provisional; Region: PRK05434 246197003264 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 246197003265 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246197003266 Coenzyme A binding pocket [chemical binding]; other site 246197003267 hypothetical protein; Reviewed; Region: PRK09588 246197003268 Uncharacterized protein family UPF0027; Region: UPF0027; cl17455 246197003269 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 246197003270 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 246197003271 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197003272 TPR motif; other site 246197003273 TPR repeat; Region: TPR_11; pfam13414 246197003274 binding surface 246197003275 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 246197003276 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197003277 active site 246197003278 phosphorylation site [posttranslational modification] 246197003279 intermolecular recognition site; other site 246197003280 dimerization interface [polypeptide binding]; other site 246197003281 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197003282 Walker A motif; other site 246197003283 ATP binding site [chemical binding]; other site 246197003284 Walker B motif; other site 246197003285 arginine finger; other site 246197003286 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 246197003287 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 246197003288 nudix motif; other site 246197003289 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 246197003290 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 246197003291 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 246197003292 dimer interface [polypeptide binding]; other site 246197003293 putative CheW interface [polypeptide binding]; other site 246197003294 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197003295 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246197003296 dimerization interface [polypeptide binding]; other site 246197003297 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197003298 dimer interface [polypeptide binding]; other site 246197003299 phosphorylation site [posttranslational modification] 246197003300 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197003301 ATP binding site [chemical binding]; other site 246197003302 Mg2+ binding site [ion binding]; other site 246197003303 G-X-G motif; other site 246197003304 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 246197003305 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 246197003306 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 246197003307 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 246197003308 DNA repair protein RadA; Provisional; Region: PRK11823 246197003309 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 246197003310 Walker A motif/ATP binding site; other site 246197003311 ATP binding site [chemical binding]; other site 246197003312 Walker B motif; other site 246197003313 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 246197003314 biotin synthase; Region: bioB; TIGR00433 246197003315 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246197003316 FeS/SAM binding site; other site 246197003317 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 246197003318 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 246197003319 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 246197003320 substrate-cofactor binding pocket; other site 246197003321 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246197003322 catalytic residue [active] 246197003323 AAA domain; Region: AAA_26; pfam13500 246197003324 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 246197003325 succinyldiaminopimelate transaminase; Region: DapC; TIGR03537 246197003326 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246197003327 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246197003328 homodimer interface [polypeptide binding]; other site 246197003329 catalytic residue [active] 246197003330 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 246197003331 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 246197003332 ligand binding site [chemical binding]; other site 246197003333 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197003334 TPR repeat; Region: TPR_11; pfam13414 246197003335 binding surface 246197003336 TPR motif; other site 246197003337 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 246197003338 active site 246197003339 substrate-binding site [chemical binding]; other site 246197003340 metal-binding site [ion binding] 246197003341 GTP binding site [chemical binding]; other site 246197003342 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 246197003343 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 246197003344 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 246197003345 TrkA-C domain; Region: TrkA_C; pfam02080 246197003346 TrkA-C domain; Region: TrkA_C; pfam02080 246197003347 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 246197003348 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 246197003349 active site 246197003350 dinuclear metal binding site [ion binding]; other site 246197003351 dimerization interface [polypeptide binding]; other site 246197003352 Predicted acetyltransferase [General function prediction only]; Region: COG3393 246197003353 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 246197003354 Patatin-like phospholipase; Region: Patatin; pfam01734 246197003355 nucleophile elbow; other site 246197003356 Uncharacterized protein conserved in archaea (DUF2099); Region: DUF2099; cl01645 246197003357 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 246197003358 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 246197003359 active site 246197003360 HIGH motif; other site 246197003361 nucleotide binding site [chemical binding]; other site 246197003362 active site 246197003363 KMSKS motif; other site 246197003364 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 246197003365 putative active site [active] 246197003366 putative metal binding site [ion binding]; other site 246197003367 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 246197003368 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 246197003369 active site 246197003370 metal binding site [ion binding]; metal-binding site 246197003371 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 246197003372 cyclase homology domain; Region: CHD; cd07302 246197003373 nucleotidyl binding site; other site 246197003374 metal binding site [ion binding]; metal-binding site 246197003375 dimer interface [polypeptide binding]; other site 246197003376 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 246197003377 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246197003378 FeS/SAM binding site; other site 246197003379 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 246197003380 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 246197003381 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 246197003382 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197003383 active site 246197003384 phosphorylation site [posttranslational modification] 246197003385 intermolecular recognition site; other site 246197003386 dimerization interface [polypeptide binding]; other site 246197003387 LytTr DNA-binding domain; Region: LytTR; smart00850 246197003388 Histidine kinase; Region: His_kinase; pfam06580 246197003389 3-isopropylmalate dehydratase large subunit [Amino acid transport and metabolism]; Region: LeuC; COG0065 246197003390 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 246197003391 substrate binding site [chemical binding]; other site 246197003392 ligand binding site [chemical binding]; other site 246197003393 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 246197003394 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 246197003395 substrate binding site [chemical binding]; other site 246197003396 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 246197003397 tartrate dehydrogenase; Region: TTC; TIGR02089 246197003398 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 246197003399 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cd03174 246197003400 active site 246197003401 catalytic residues [active] 246197003402 metal binding site [ion binding]; metal-binding site 246197003403 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 246197003404 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 246197003405 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 246197003406 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 246197003407 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246197003408 Walker A/P-loop; other site 246197003409 ATP binding site [chemical binding]; other site 246197003410 Q-loop/lid; other site 246197003411 ABC transporter signature motif; other site 246197003412 Walker B; other site 246197003413 D-loop; other site 246197003414 H-loop/switch region; other site 246197003415 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 246197003416 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 246197003417 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 246197003418 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 246197003419 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 246197003420 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 246197003421 Phosphotransferase enzyme family; Region: APH; pfam01636 246197003422 active site 246197003423 ATP binding site [chemical binding]; other site 246197003424 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246197003425 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 246197003426 acyl-activating enzyme (AAE) consensus motif; other site 246197003427 AMP binding site [chemical binding]; other site 246197003428 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197003429 Condensation domain; Region: Condensation; pfam00668 246197003430 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197003431 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197003432 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246197003433 acyl-activating enzyme (AAE) consensus motif; other site 246197003434 AMP binding site [chemical binding]; other site 246197003435 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197003436 P-aminobenzoate N-oxygenase AurF; Region: AurF; pfam11583 246197003437 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 246197003438 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 246197003439 C factor cell-cell signaling protein; Provisional; Region: PRK09009 246197003440 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 246197003441 NADP binding site [chemical binding]; other site 246197003442 homodimer interface [polypeptide binding]; other site 246197003443 active site 246197003444 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 246197003445 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 246197003446 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 246197003447 glycogen synthase; Provisional; Region: glgA; PRK00654 246197003448 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 246197003449 ADP-binding pocket [chemical binding]; other site 246197003450 homodimer interface [polypeptide binding]; other site 246197003451 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197003452 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197003453 active site 246197003454 ATP binding site [chemical binding]; other site 246197003455 substrate binding site [chemical binding]; other site 246197003456 activation loop (A-loop); other site 246197003457 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 246197003458 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 246197003459 Domain of unknown function DUF21; Region: DUF21; pfam01595 246197003460 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 246197003461 Transporter associated domain; Region: CorC_HlyC; smart01091 246197003462 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 246197003463 conserved hypothetical protein; Region: TIGR02270 246197003464 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 246197003465 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 246197003466 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 246197003467 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 246197003468 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 246197003469 N-terminal plug; other site 246197003470 ligand-binding site [chemical binding]; other site 246197003471 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105 246197003472 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 246197003473 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 246197003474 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 246197003475 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 246197003476 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 246197003477 intersubunit interface [polypeptide binding]; other site 246197003478 ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism]; Region: FepD; COG0609 246197003479 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 246197003480 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 246197003481 Walker A/P-loop; other site 246197003482 ATP binding site [chemical binding]; other site 246197003483 Q-loop/lid; other site 246197003484 ABC transporter signature motif; other site 246197003485 Walker B; other site 246197003486 D-loop; other site 246197003487 H-loop/switch region; other site 246197003488 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 246197003489 Integrase core domain; Region: rve; pfam00665 246197003490 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 246197003491 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 246197003492 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197003493 TPR motif; other site 246197003494 binding surface 246197003495 TPR repeat; Region: TPR_11; pfam13414 246197003496 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197003497 binding surface 246197003498 TPR motif; other site 246197003499 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197003500 binding surface 246197003501 TPR repeat; Region: TPR_11; pfam13414 246197003502 TPR motif; other site 246197003503 TPR repeat; Region: TPR_11; pfam13414 246197003504 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197003505 binding surface 246197003506 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 246197003507 TPR motif; other site 246197003508 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 246197003509 binding surface 246197003510 TPR motif; other site 246197003511 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 246197003512 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197003513 binding surface 246197003514 TPR motif; other site 246197003515 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 246197003516 FHA domain; Region: FHA; pfam00498 246197003517 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 246197003518 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 246197003519 metal ion-dependent adhesion site (MIDAS); other site 246197003520 von Willebrand factor type A domain; Region: VWA_2; pfam13519 246197003521 metal ion-dependent adhesion site (MIDAS); other site 246197003522 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 246197003523 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 246197003524 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 246197003525 Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618 246197003526 Domain of unknown function (DUF3332); Region: DUF3332; pfam11810 246197003527 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246197003528 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 246197003529 phosphopeptide binding site; other site 246197003530 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197003531 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 246197003532 Walker A motif; other site 246197003533 ATP binding site [chemical binding]; other site 246197003534 Walker B motif; other site 246197003535 arginine finger; other site 246197003536 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 246197003537 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197003538 S-adenosylmethionine binding site [chemical binding]; other site 246197003539 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 246197003540 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197003541 active site 246197003542 phosphorylation site [posttranslational modification] 246197003543 intermolecular recognition site; other site 246197003544 dimerization interface [polypeptide binding]; other site 246197003545 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 246197003546 DNA binding site [nucleotide binding] 246197003547 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197003548 dimer interface [polypeptide binding]; other site 246197003549 phosphorylation site [posttranslational modification] 246197003550 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197003551 ATP binding site [chemical binding]; other site 246197003552 Mg2+ binding site [ion binding]; other site 246197003553 G-X-G motif; other site 246197003554 tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791 246197003555 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 246197003556 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 246197003557 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 246197003558 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 246197003559 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 246197003560 HflX GTPase family; Region: HflX; cd01878 246197003561 G1 box; other site 246197003562 GTP/Mg2+ binding site [chemical binding]; other site 246197003563 Switch I region; other site 246197003564 G2 box; other site 246197003565 G3 box; other site 246197003566 Switch II region; other site 246197003567 G4 box; other site 246197003568 G5 box; other site 246197003569 gamma-glutamyl kinase; Provisional; Region: PRK05429 246197003570 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 246197003571 nucleotide binding site [chemical binding]; other site 246197003572 homotetrameric interface [polypeptide binding]; other site 246197003573 putative phosphate binding site [ion binding]; other site 246197003574 putative allosteric binding site; other site 246197003575 PUA domain; Region: PUA; pfam01472 246197003576 Predicted transcriptional regulator [Transcription]; Region: COG2378 246197003577 WYL domain; Region: WYL; pfam13280 246197003578 Predicted transcriptional regulator [Transcription]; Region: COG2378 246197003579 WYL domain; Region: WYL; pfam13280 246197003580 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246197003581 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 246197003582 phosphopeptide binding site; other site 246197003583 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 246197003584 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 246197003585 putative active site [active] 246197003586 catalytic site [active] 246197003587 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 246197003588 putative active site [active] 246197003589 catalytic site [active] 246197003590 aconitate hydratase; Validated; Region: PRK09277 246197003591 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 246197003592 substrate binding site [chemical binding]; other site 246197003593 ligand binding site [chemical binding]; other site 246197003594 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 246197003595 substrate binding site [chemical binding]; other site 246197003596 HD domain; Region: HD_4; pfam13328 246197003597 Neisseria PilC beta-propeller domain; Region: Neisseria_PilC; pfam05567 246197003598 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 246197003599 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 246197003600 RF-1 domain; Region: RF-1; pfam00472 246197003601 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 246197003602 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 246197003603 putative active site [active] 246197003604 Zn binding site [ion binding]; other site 246197003605 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 246197003606 metal ion-dependent adhesion site (MIDAS); other site 246197003607 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 246197003608 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 246197003609 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 246197003610 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 246197003611 Walker A/P-loop; other site 246197003612 ATP binding site [chemical binding]; other site 246197003613 Q-loop/lid; other site 246197003614 ABC transporter signature motif; other site 246197003615 Walker B; other site 246197003616 D-loop; other site 246197003617 H-loop/switch region; other site 246197003618 Response regulator receiver domain; Region: Response_reg; pfam00072 246197003619 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197003620 active site 246197003621 phosphorylation site [posttranslational modification] 246197003622 intermolecular recognition site; other site 246197003623 dimerization interface [polypeptide binding]; other site 246197003624 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 246197003625 active site 246197003626 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK12933 246197003627 Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin; Region: M3A_TOP; cd06455 246197003628 active site 246197003629 Zn binding site [ion binding]; other site 246197003630 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 246197003631 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246197003632 active site 246197003633 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 246197003634 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 246197003635 N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains) [Cell envelope biogenesis, outer membrane]; Region: GlmU; COG1207 246197003636 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 246197003637 Substrate binding site; other site 246197003638 Mg++ binding site; other site 246197003639 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 246197003640 active site 246197003641 substrate binding site [chemical binding]; other site 246197003642 CoA binding site [chemical binding]; other site 246197003643 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 246197003644 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 246197003645 glutaminase active site [active] 246197003646 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 246197003647 dimer interface [polypeptide binding]; other site 246197003648 active site 246197003649 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 246197003650 dimer interface [polypeptide binding]; other site 246197003651 active site 246197003652 recombinase A; Provisional; Region: recA; PRK09354 246197003653 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 246197003654 hexamer interface [polypeptide binding]; other site 246197003655 Walker A motif; other site 246197003656 ATP binding site [chemical binding]; other site 246197003657 Walker B motif; other site 246197003658 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 246197003659 putative active site [active] 246197003660 putative metal binding site [ion binding]; other site 246197003661 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 246197003662 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 246197003663 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 246197003664 Coenzyme A binding pocket [chemical binding]; other site 246197003665 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 246197003666 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 246197003667 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 246197003668 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 246197003669 RNA binding site [nucleotide binding]; other site 246197003670 HSP90 family protein; Provisional; Region: PRK14083 246197003671 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197003672 ATP binding site [chemical binding]; other site 246197003673 Mg2+ binding site [ion binding]; other site 246197003674 G-X-G motif; other site 246197003675 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 246197003676 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 246197003677 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 246197003678 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 246197003679 HEAT repeats; Region: HEAT_2; pfam13646 246197003680 HEAT repeats; Region: HEAT_2; pfam13646 246197003681 HEAT repeats; Region: HEAT_2; pfam13646 246197003682 HAMP domain; Region: HAMP; pfam00672 246197003683 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 246197003684 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 246197003685 putative active site [active] 246197003686 substrate binding site [chemical binding]; other site 246197003687 putative cosubstrate binding site; other site 246197003688 catalytic site [active] 246197003689 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 246197003690 substrate binding site [chemical binding]; other site 246197003691 Dehydroquinase class II; Region: DHquinase_II; pfam01220 246197003692 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cl00505 246197003693 trimer interface [polypeptide binding]; other site 246197003694 active site 246197003695 dimer interface [polypeptide binding]; other site 246197003696 16S rRNA methyltransferase B; Provisional; Region: PRK14902 246197003697 NusB family; Region: NusB; pfam01029 246197003698 putative RNA binding site [nucleotide binding]; other site 246197003699 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197003700 S-adenosylmethionine binding site [chemical binding]; other site 246197003701 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246197003702 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246197003703 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 246197003704 dimerization interface [polypeptide binding]; other site 246197003705 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 246197003706 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 246197003707 classical (c) SDRs; Region: SDR_c; cd05233 246197003708 NAD(P) binding site [chemical binding]; other site 246197003709 active site 246197003710 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 246197003711 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 246197003712 transaminase; Validated; Region: PRK07324 246197003713 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246197003714 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246197003715 homodimer interface [polypeptide binding]; other site 246197003716 catalytic residue [active] 246197003717 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 246197003718 Protein phosphatase 2C; Region: PP2C; pfam00481 246197003719 active site 246197003720 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 246197003721 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246197003722 dimerization interface [polypeptide binding]; other site 246197003723 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 246197003724 dimer interface [polypeptide binding]; other site 246197003725 putative CheW interface [polypeptide binding]; other site 246197003726 PQQ-like domain; Region: PQQ_2; pfam13360 246197003727 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 246197003728 Trp docking motif [polypeptide binding]; other site 246197003729 active site 246197003730 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246197003731 classical (c) SDRs; Region: SDR_c; cd05233 246197003732 NAD(P) binding site [chemical binding]; other site 246197003733 active site 246197003734 Peptidase M3-like family, a zincin metallopeptidase, includes M3 and M32 families; Region: M3_like; cd06258 246197003735 active site 246197003736 Zn binding site [ion binding]; other site 246197003737 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 246197003738 RNA binding surface [nucleotide binding]; other site 246197003739 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 246197003740 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 246197003741 active site 246197003742 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 246197003743 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 246197003744 active site 246197003745 CoA binding domain; Region: CoA_binding; cl17356 246197003746 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 246197003747 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 246197003748 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 246197003749 active site 246197003750 tetramer interface; other site 246197003751 glutathione S-transferase; Region: PLN02395 246197003752 GST_N family, Class Phi subfamily; composed of plant-specific class Phi GSTs and related fungal and bacterial proteins. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide...; Region: GST_N_Phi; cd03053 246197003753 C-terminal domain interface [polypeptide binding]; other site 246197003754 GSH binding site (G-site) [chemical binding]; other site 246197003755 dimer interface [polypeptide binding]; other site 246197003756 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 246197003757 N-terminal domain interface [polypeptide binding]; other site 246197003758 dimer interface [polypeptide binding]; other site 246197003759 substrate binding pocket (H-site) [chemical binding]; other site 246197003760 primosome assembly protein PriA; Validated; Region: PRK05580 246197003761 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246197003762 ATP binding site [chemical binding]; other site 246197003763 putative Mg++ binding site [ion binding]; other site 246197003764 helicase superfamily c-terminal domain; Region: HELICc; smart00490 246197003765 ATP-binding site [chemical binding]; other site 246197003766 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197003767 active site 246197003768 phosphorylation site [posttranslational modification] 246197003769 intermolecular recognition site; other site 246197003770 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 246197003771 HSP70 interaction site [polypeptide binding]; other site 246197003772 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 246197003773 active site 246197003774 catalytic residues [active] 246197003775 metal binding site [ion binding]; metal-binding site 246197003776 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 246197003777 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 246197003778 minor groove reading motif; other site 246197003779 helix-hairpin-helix signature motif; other site 246197003780 substrate binding pocket [chemical binding]; other site 246197003781 active site 246197003782 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 246197003783 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 246197003784 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 246197003785 tetramer interface [polypeptide binding]; other site 246197003786 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246197003787 catalytic residue [active] 246197003788 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 246197003789 Peptidase family M23; Region: Peptidase_M23; pfam01551 246197003790 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 246197003791 IHF dimer interface [polypeptide binding]; other site 246197003792 IHF - DNA interface [nucleotide binding]; other site 246197003793 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 246197003794 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 246197003795 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 246197003796 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 246197003797 competence damage-inducible protein A; Provisional; Region: PRK00549 246197003798 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 246197003799 putative MPT binding site; other site 246197003800 Competence-damaged protein; Region: CinA; pfam02464 246197003801 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 246197003802 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 246197003803 hexamer interface [polypeptide binding]; other site 246197003804 RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468 246197003805 Walker A motif; other site 246197003806 ATP binding site [chemical binding]; other site 246197003807 Walker B motif; other site 246197003808 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 246197003809 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 246197003810 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 246197003811 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 246197003812 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 246197003813 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197003814 Walker A motif; other site 246197003815 ATP binding site [chemical binding]; other site 246197003816 Walker B motif; other site 246197003817 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 246197003818 Myxococcales-restricted protein, TIGR02265 family; Region: Mxa_TIGR02265 246197003819 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 246197003820 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 246197003821 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 246197003822 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 246197003823 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 246197003824 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197003825 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 246197003826 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 246197003827 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 246197003828 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 246197003829 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246197003830 FeS/SAM binding site; other site 246197003831 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 246197003832 membrane protein; Provisional; Region: PRK14400 246197003833 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 246197003834 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 246197003835 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 246197003836 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 246197003837 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 246197003838 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 246197003839 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 246197003840 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 246197003841 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 246197003842 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 246197003843 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 246197003844 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 246197003845 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 246197003846 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 246197003847 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 246197003848 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 246197003849 GatB domain; Region: GatB_Yqey; smart00845 246197003850 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 246197003851 Predicted amidohydrolase [General function prediction only]; Region: COG0388 246197003852 active site 246197003853 catalytic triad [active] 246197003854 dimer interface [polypeptide binding]; other site 246197003855 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 246197003856 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 246197003857 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171 246197003858 Protein kinase; unclassified specificity; Region: STYKc; smart00221 246197003859 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197003860 active site 246197003861 ATP binding site [chemical binding]; other site 246197003862 substrate binding site [chemical binding]; other site 246197003863 activation loop (A-loop); other site 246197003864 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 246197003865 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 246197003866 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 246197003867 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 246197003868 GTP1/OBG; Region: GTP1_OBG; pfam01018 246197003869 Obg GTPase; Region: Obg; cd01898 246197003870 G1 box; other site 246197003871 GTP/Mg2+ binding site [chemical binding]; other site 246197003872 Switch I region; other site 246197003873 G2 box; other site 246197003874 G3 box; other site 246197003875 Switch II region; other site 246197003876 G4 box; other site 246197003877 G5 box; other site 246197003878 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 246197003879 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 246197003880 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 246197003881 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 246197003882 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 246197003883 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246197003884 FeS/SAM binding site; other site 246197003885 TRAM domain; Region: TRAM; pfam01938 246197003886 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 246197003887 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 246197003888 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 246197003889 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 246197003890 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 246197003891 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197003892 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197003893 active site 246197003894 ATP binding site [chemical binding]; other site 246197003895 substrate binding site [chemical binding]; other site 246197003896 activation loop (A-loop); other site 246197003897 Tetratricopeptide repeat; Region: TPR_12; pfam13424 246197003898 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197003899 TPR motif; other site 246197003900 binding surface 246197003901 Tetratricopeptide repeat; Region: TPR_12; pfam13424 246197003902 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 246197003903 Putative catalytic NodB homology domain of uncharacterized prokaryotic polysaccharide deacetylases which consist of a 6-stranded beta/alpha barrel; Region: CE4_DAC_u1_6s; cd10970 246197003904 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 246197003905 putative active site [active] 246197003906 putative metal binding site [ion binding]; other site 246197003907 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 246197003908 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197003909 Walker A motif; other site 246197003910 ATP binding site [chemical binding]; other site 246197003911 Walker B motif; other site 246197003912 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 246197003913 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197003914 Walker A motif; other site 246197003915 ATP binding site [chemical binding]; other site 246197003916 Walker B motif; other site 246197003917 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 246197003918 peptide chain release factor 2; Validated; Region: prfB; PRK00578 246197003919 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 246197003920 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 246197003921 active site 246197003922 hypothetical protein; Provisional; Region: PRK06834 246197003923 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 246197003924 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 246197003925 active site 246197003926 Trp docking motif [polypeptide binding]; other site 246197003927 PQQ-like domain; Region: PQQ_2; pfam13360 246197003928 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 246197003929 ATP binding site [chemical binding]; other site 246197003930 substrate interface [chemical binding]; other site 246197003931 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 246197003932 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 246197003933 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 246197003934 calcium binding site 2 [ion binding]; other site 246197003935 active site 246197003936 catalytic triad [active] 246197003937 calcium binding site 1 [ion binding]; other site 246197003938 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 246197003939 Active_site [active] 246197003940 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 246197003941 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 246197003942 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 246197003943 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 246197003944 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 246197003945 metal ion-dependent adhesion site (MIDAS); other site 246197003946 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 246197003947 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 246197003948 active site 246197003949 metal binding site [ion binding]; metal-binding site 246197003950 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246197003951 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 246197003952 RNA polymerase sigma factor; Provisional; Region: PRK12513 246197003953 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 246197003954 DNA binding residues [nucleotide binding] 246197003955 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 246197003956 CoenzymeA binding site [chemical binding]; other site 246197003957 subunit interaction site [polypeptide binding]; other site 246197003958 PHB binding site; other site 246197003959 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 246197003960 Part of AAA domain; Region: AAA_19; pfam13245 246197003961 Family description; Region: UvrD_C_2; pfam13538 246197003962 PQQ-like domain; Region: PQQ_2; pfam13360 246197003963 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 246197003964 active site 246197003965 Trp docking motif [polypeptide binding]; other site 246197003966 PQQ-like domain; Region: PQQ_2; pfam13360 246197003967 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 246197003968 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 246197003969 active site 246197003970 purine riboside binding site [chemical binding]; other site 246197003971 short chain dehydrogenase; Provisional; Region: PRK07062 246197003972 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 246197003973 putative NAD(P) binding site [chemical binding]; other site 246197003974 putative active site [active] 246197003975 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 246197003976 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 246197003977 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 246197003978 Coenzyme A binding pocket [chemical binding]; other site 246197003979 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 246197003980 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 246197003981 ligand binding site; other site 246197003982 oligomer interface; other site 246197003983 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 246197003984 dimer interface [polypeptide binding]; other site 246197003985 N-terminal domain interface [polypeptide binding]; other site 246197003986 sulfate 1 binding site; other site 246197003987 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246197003988 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 246197003989 phosphopeptide binding site; other site 246197003990 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 246197003991 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 246197003992 metal binding site [ion binding]; metal-binding site 246197003993 active site 246197003994 I-site; other site 246197003995 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246197003996 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 246197003997 NAD(P) binding site [chemical binding]; other site 246197003998 active site 246197003999 fatty acyl-CoA reductase; Region: PLN02996 246197004000 NAD(P) binding site [chemical binding]; other site 246197004001 Male sterility protein; Region: NAD_binding_4; pfam07993 246197004002 active site 246197004003 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246197004004 active site 246197004005 C-terminal domain of fatty acyl CoA reductases; Region: FAR_C; cd09071 246197004006 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 246197004007 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 246197004008 acyl-activating enzyme (AAE) consensus motif; other site 246197004009 putative AMP binding site [chemical binding]; other site 246197004010 putative active site [active] 246197004011 putative CoA binding site [chemical binding]; other site 246197004012 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 246197004013 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 246197004014 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 246197004015 putative acyl-acceptor binding pocket; other site 246197004016 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 246197004017 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 246197004018 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 246197004019 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 246197004020 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246197004021 NAD(P) binding site [chemical binding]; other site 246197004022 active site 246197004023 SWIB/MDM2 domain; Region: SWIB; pfam02201 246197004024 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 246197004025 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 246197004026 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 246197004027 active site 246197004028 catalytic site [active] 246197004029 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 246197004030 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 246197004031 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 246197004032 active site 246197004033 catalytic site [active] 246197004034 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 246197004035 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 246197004036 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 246197004037 ferrochelatase; Reviewed; Region: hemH; PRK00035 246197004038 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 246197004039 C-terminal domain interface [polypeptide binding]; other site 246197004040 active site 246197004041 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 246197004042 active site 246197004043 N-terminal domain interface [polypeptide binding]; other site 246197004044 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 246197004045 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246197004046 ATP binding site [chemical binding]; other site 246197004047 putative Mg++ binding site [ion binding]; other site 246197004048 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246197004049 nucleotide binding region [chemical binding]; other site 246197004050 ATP-binding site [chemical binding]; other site 246197004051 HEAT repeats; Region: HEAT_2; pfam13646 246197004052 HEAT repeat; Region: HEAT; pfam02985 246197004053 Protein of unknown function (Gmx_para_CXXCG); Region: Gmx_para_CXXCG; pfam09535 246197004054 Myxococcus xanthus paralogous lipoprotein family TIGR02269; Region: TIGR02269 246197004055 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 246197004056 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 246197004057 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 246197004058 putative hydrophobic ligand binding site [chemical binding]; other site 246197004059 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246197004060 TIGR01777 family protein; Region: yfcH 246197004061 NAD(P) binding site [chemical binding]; other site 246197004062 active site 246197004063 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 246197004064 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 246197004065 Walker A/P-loop; other site 246197004066 ATP binding site [chemical binding]; other site 246197004067 Q-loop/lid; other site 246197004068 ABC transporter signature motif; other site 246197004069 Walker B; other site 246197004070 D-loop; other site 246197004071 H-loop/switch region; other site 246197004072 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 246197004073 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 246197004074 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 246197004075 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 246197004076 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 246197004077 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 246197004078 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197004079 active site 246197004080 phosphorylation site [posttranslational modification] 246197004081 intermolecular recognition site; other site 246197004082 dimerization interface [polypeptide binding]; other site 246197004083 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197004084 dimer interface [polypeptide binding]; other site 246197004085 phosphorylation site [posttranslational modification] 246197004086 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197004087 ATP binding site [chemical binding]; other site 246197004088 Mg2+ binding site [ion binding]; other site 246197004089 G-X-G motif; other site 246197004090 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 246197004091 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 246197004092 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 246197004093 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 246197004094 [2Fe-2S] cluster binding site [ion binding]; other site 246197004095 Hemerythrin-like domain; Region: Hr-like; cd12108 246197004096 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 246197004097 endonuclease III; Region: ENDO3c; smart00478 246197004098 minor groove reading motif; other site 246197004099 helix-hairpin-helix signature motif; other site 246197004100 substrate binding pocket [chemical binding]; other site 246197004101 active site 246197004102 muropeptide transporter; Reviewed; Region: ampG; PRK11902 246197004103 muropeptide transporter; Validated; Region: ampG; cl17669 246197004104 Amino acid permease; Region: AA_permease_2; pfam13520 246197004105 Methyltransferase domain; Region: Methyltransf_31; pfam13847 246197004106 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197004107 S-adenosylmethionine binding site [chemical binding]; other site 246197004108 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 246197004109 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246197004110 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246197004111 homodimer interface [polypeptide binding]; other site 246197004112 catalytic residue [active] 246197004113 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 246197004114 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 246197004115 dimerization interface [polypeptide binding]; other site 246197004116 DPS ferroxidase diiron center [ion binding]; other site 246197004117 ion pore; other site 246197004118 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 246197004119 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 246197004120 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 246197004121 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 246197004122 dimer interface [polypeptide binding]; other site 246197004123 decamer (pentamer of dimers) interface [polypeptide binding]; other site 246197004124 catalytic triad [active] 246197004125 peroxidatic and resolving cysteines [active] 246197004126 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 246197004127 GAF domain; Region: GAF_3; pfam13492 246197004128 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197004129 Walker A motif; other site 246197004130 ATP binding site [chemical binding]; other site 246197004131 Walker B motif; other site 246197004132 arginine finger; other site 246197004133 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 246197004134 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 246197004135 putative active site [active] 246197004136 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 246197004137 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 246197004138 Cytochrome c; Region: Cytochrom_C; pfam00034 246197004139 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 246197004140 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 246197004141 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246197004142 catalytic residue [active] 246197004143 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 246197004144 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 246197004145 dimer interface [polypeptide binding]; other site 246197004146 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246197004147 catalytic residue [active] 246197004148 serine O-acetyltransferase; Region: cysE; TIGR01172 246197004149 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 246197004150 trimer interface [polypeptide binding]; other site 246197004151 active site 246197004152 substrate binding site [chemical binding]; other site 246197004153 CoA binding site [chemical binding]; other site 246197004154 AMP-binding domain protein; Validated; Region: PRK08315 246197004155 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246197004156 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 246197004157 acyl-activating enzyme (AAE) consensus motif; other site 246197004158 putative AMP binding site [chemical binding]; other site 246197004159 putative active site [active] 246197004160 putative CoA binding site [chemical binding]; other site 246197004161 TfoX N-terminal domain; Region: TfoX_N; pfam04993 246197004162 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246197004163 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246197004164 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 246197004165 dimerization interface [polypeptide binding]; other site 246197004166 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246197004167 putative substrate translocation pore; other site 246197004168 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197004169 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197004170 active site 246197004171 ATP binding site [chemical binding]; other site 246197004172 substrate binding site [chemical binding]; other site 246197004173 activation loop (A-loop); other site 246197004174 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 246197004175 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 246197004176 Predicted membrane protein [Function unknown]; Region: COG1238 246197004177 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 246197004178 putative metal binding site [ion binding]; other site 246197004179 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 246197004180 putative phosphate binding site [ion binding]; other site 246197004181 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 246197004182 Lamin Tail Domain; Region: LTD; pfam00932 246197004183 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 246197004184 Uncharacterized conserved protein [Function unknown]; Region: COG2966 246197004185 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 246197004186 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 246197004187 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 246197004188 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 246197004189 RNA binding surface [nucleotide binding]; other site 246197004190 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 246197004191 active site 246197004192 uracil binding [chemical binding]; other site 246197004193 Aminotransferase class IV; Region: Aminotran_4; pfam01063 246197004194 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 246197004195 substrate-cofactor binding pocket; other site 246197004196 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 246197004197 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 246197004198 glutamine binding [chemical binding]; other site 246197004199 catalytic triad [active] 246197004200 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 246197004201 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 246197004202 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 246197004203 Domain of unknown function DUF87; Region: DUF87; pfam01935 246197004204 AAA-like domain; Region: AAA_10; pfam12846 246197004205 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 246197004206 putative active site [active] 246197004207 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 246197004208 hypothetical protein; Provisional; Region: PRK07236 246197004209 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 246197004210 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 246197004211 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 246197004212 putative NAD(P) binding site [chemical binding]; other site 246197004213 active site 246197004214 putative substrate binding site [chemical binding]; other site 246197004215 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 246197004216 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 246197004217 putative acyl-acceptor binding pocket; other site 246197004218 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 246197004219 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 246197004220 Walker A/P-loop; other site 246197004221 ATP binding site [chemical binding]; other site 246197004222 Q-loop/lid; other site 246197004223 ABC transporter signature motif; other site 246197004224 Walker B; other site 246197004225 D-loop; other site 246197004226 H-loop/switch region; other site 246197004227 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 246197004228 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 246197004229 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 246197004230 Methyltransferase domain; Region: Methyltransf_18; pfam12847 246197004231 capreomycidine synthase; Region: viomycin_VioD; TIGR03947 246197004232 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246197004233 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246197004234 homodimer interface [polypeptide binding]; other site 246197004235 catalytic residue [active] 246197004236 Fatty acid desaturase; Region: FA_desaturase; pfam00487 246197004237 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 246197004238 putative di-iron ligands [ion binding]; other site 246197004239 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 246197004240 Methyltransferase domain; Region: Methyltransf_23; pfam13489 246197004241 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197004242 S-adenosylmethionine binding site [chemical binding]; other site 246197004243 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 246197004244 The adenylation domain (A domain) of a family of nonribosomal peptide synthetases (NRPSs) synthesizing toxins and antitumor agents; Region: A_NRPS_TubE_like; cd05906 246197004245 acyl-activating enzyme (AAE) consensus motif; other site 246197004246 putative AMP binding site [chemical binding]; other site 246197004247 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 246197004248 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 246197004249 putative NADP binding site [chemical binding]; other site 246197004250 active site 246197004251 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197004252 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 246197004253 FtsX-like permease family; Region: FtsX; pfam02687 246197004254 Condensation domain; Region: Condensation; pfam00668 246197004255 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197004256 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197004257 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246197004258 acyl-activating enzyme (AAE) consensus motif; other site 246197004259 AMP binding site [chemical binding]; other site 246197004260 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197004261 Condensation domain; Region: Condensation; pfam00668 246197004262 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197004263 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197004264 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246197004265 acyl-activating enzyme (AAE) consensus motif; other site 246197004266 AMP binding site [chemical binding]; other site 246197004267 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197004268 Condensation domain; Region: Condensation; pfam00668 246197004269 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197004270 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197004271 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246197004272 acyl-activating enzyme (AAE) consensus motif; other site 246197004273 AMP binding site [chemical binding]; other site 246197004274 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197004275 Condensation domain; Region: Condensation; pfam00668 246197004276 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197004277 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197004278 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246197004279 acyl-activating enzyme (AAE) consensus motif; other site 246197004280 AMP binding site [chemical binding]; other site 246197004281 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197004282 Condensation domain; Region: Condensation; pfam00668 246197004283 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197004284 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246197004285 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 246197004286 acyl-activating enzyme (AAE) consensus motif; other site 246197004287 AMP binding site [chemical binding]; other site 246197004288 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197004289 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 246197004290 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 246197004291 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 246197004292 iron-sulfur cluster [ion binding]; other site 246197004293 [2Fe-2S] cluster binding site [ion binding]; other site 246197004294 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 246197004295 hydrophobic ligand binding site; other site 246197004296 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 246197004297 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 246197004298 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 246197004299 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 246197004300 DNA-binding site [nucleotide binding]; DNA binding site 246197004301 RNA-binding motif; other site 246197004302 HTH domain; Region: HTH_11; pfam08279 246197004303 WYL domain; Region: WYL; pfam13280 246197004304 DNA polymerase elongation subunit (family B) [DNA replication, recombination, and repair]; Region: PolB; COG0417 246197004305 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 246197004306 active site 246197004307 catalytic site [active] 246197004308 substrate binding site [chemical binding]; other site 246197004309 DNA polymerase type-B family catalytic domain. DNA-directed DNA polymerases elongate DNA by adding nucleotide triphosphate (dNTP) residues to the 5'-end of the growing chain of DNA. DNA-directed DNA polymerases are multifunctional with both...; Region: POLBc; cl10023 246197004310 active site 246197004311 metal-binding site 246197004312 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 246197004313 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 246197004314 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 246197004315 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 246197004316 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 246197004317 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 246197004318 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 246197004319 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 246197004320 Glyco_18 domain; Region: Glyco_18; smart00636 246197004321 active site 246197004322 Right handed beta helix region; Region: Beta_helix; pfam13229 246197004323 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 246197004324 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 246197004325 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 246197004326 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 246197004327 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 246197004328 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 246197004329 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246197004330 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246197004331 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 246197004332 NAD(P) binding site [chemical binding]; other site 246197004333 active site 246197004334 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 246197004335 Rrf2 family protein; Region: rrf2_super; TIGR00738 246197004336 Transcriptional regulator; Region: Rrf2; pfam02082 246197004337 Transcriptional regulator; Region: Rrf2; cl17282 246197004338 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246197004339 YhhN-like protein; Region: YhhN; pfam07947 246197004340 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 246197004341 putative ADP-ribose binding site [chemical binding]; other site 246197004342 putative active site [active] 246197004343 DinB superfamily; Region: DinB_2; pfam12867 246197004344 Protein of unknown function (DUF2652); Region: DUF2652; pfam10851 246197004345 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 246197004346 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 246197004347 substrate binding pocket [chemical binding]; other site 246197004348 catalytic triad [active] 246197004349 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 246197004350 cleavage site 246197004351 active site 246197004352 substrate binding sites [chemical binding]; other site 246197004353 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 246197004354 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 246197004355 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 246197004356 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 246197004357 Fatty acid desaturase; Region: FA_desaturase; pfam00487 246197004358 Di-iron ligands [ion binding]; other site 246197004359 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246197004360 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246197004361 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 246197004362 structural tetrad; other site 246197004363 FOG: WD40 repeat [General function prediction only]; Region: COG2319 246197004364 FOG: WD40 repeat [General function prediction only]; Region: COG2319 246197004365 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 246197004366 structural tetrad; other site 246197004367 PemK-like protein; Region: PemK; pfam02452 246197004368 Putative zinc-finger; Region: zf-HC2; pfam13490 246197004369 RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638 246197004370 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246197004371 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246197004372 DNA binding residues [nucleotide binding] 246197004373 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246197004374 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246197004375 putative substrate translocation pore; other site 246197004376 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 246197004377 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 246197004378 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138 246197004379 conserved cys residue [active] 246197004380 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 246197004381 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246197004382 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 246197004383 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 246197004384 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 246197004385 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 246197004386 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246197004387 NAD(P) binding site [chemical binding]; other site 246197004388 active site 246197004389 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246197004390 NAD(P) binding site [chemical binding]; other site 246197004391 active site 246197004392 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 246197004393 putative acyl-acceptor binding pocket; other site 246197004394 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 246197004395 FAD binding domain; Region: FAD_binding_4; pfam01565 246197004396 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246197004397 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246197004398 Deoxyhypusine synthase; Region: DS; cl00826 246197004399 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197004400 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197004401 dimer interface [polypeptide binding]; other site 246197004402 phosphorylation site [posttranslational modification] 246197004403 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197004404 ATP binding site [chemical binding]; other site 246197004405 Mg2+ binding site [ion binding]; other site 246197004406 G-X-G motif; other site 246197004407 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 246197004408 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197004409 active site 246197004410 phosphorylation site [posttranslational modification] 246197004411 intermolecular recognition site; other site 246197004412 dimerization interface [polypeptide binding]; other site 246197004413 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 246197004414 DNA binding site [nucleotide binding] 246197004415 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246197004416 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 246197004417 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 246197004418 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246197004419 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246197004420 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 246197004421 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 246197004422 dimerization interface [polypeptide binding]; other site 246197004423 substrate binding pocket [chemical binding]; other site 246197004424 Uncharacterized conserved protein [Function unknown]; Region: COG5649 246197004425 Domain of unknown function (DU1801); Region: DUF1801; cl17490 246197004426 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246197004427 Coenzyme A binding pocket [chemical binding]; other site 246197004428 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 246197004429 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 246197004430 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 246197004431 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 246197004432 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 246197004433 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 246197004434 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 246197004435 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 246197004436 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 246197004437 homotrimer interaction site [polypeptide binding]; other site 246197004438 putative active site [active] 246197004439 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 246197004440 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 246197004441 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 246197004442 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 246197004443 Ferritin-like; Region: Ferritin-like; pfam12902 246197004444 aminoglycoside resistance protein; Provisional; Region: PRK13746 246197004445 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 246197004446 active site 246197004447 NTP binding site [chemical binding]; other site 246197004448 metal binding triad [ion binding]; metal-binding site 246197004449 antibiotic binding site [chemical binding]; other site 246197004450 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 246197004451 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246197004452 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 246197004453 aminotransferase; Validated; Region: PRK07777 246197004454 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 246197004455 Kelch motif; Region: Kelch_6; pfam13964 246197004456 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 246197004457 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 246197004458 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 246197004459 RNA polymerase sigma-70 factor, Myxococcales family 1; Region: Sig-70_gmx1; TIGR03001 246197004460 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246197004461 DNA binding residues [nucleotide binding] 246197004462 Putative zinc-finger; Region: zf-HC2; pfam13490 246197004463 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246197004464 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197004465 active site 246197004466 ATP binding site [chemical binding]; other site 246197004467 substrate binding site [chemical binding]; other site 246197004468 activation loop (A-loop); other site 246197004469 Tetratricopeptide repeat; Region: TPR_12; pfam13424 246197004470 Tetratricopeptide repeat; Region: TPR_12; pfam13424 246197004471 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197004472 binding surface 246197004473 TPR motif; other site 246197004474 Tetratricopeptide repeat; Region: TPR_12; pfam13424 246197004475 Tetratricopeptide repeat; Region: TPR_12; pfam13424 246197004476 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 246197004477 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246197004478 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 246197004479 dimerization interface [polypeptide binding]; other site 246197004480 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 246197004481 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 246197004482 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 246197004483 putative transposase OrfB; Reviewed; Region: PHA02517 246197004484 HTH-like domain; Region: HTH_21; pfam13276 246197004485 Integrase core domain; Region: rve; pfam00665 246197004486 Integrase core domain; Region: rve_3; pfam13683 246197004487 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 246197004488 Transposase; Region: HTH_Tnp_1; pfam01527 246197004489 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238 246197004490 dimer interface [polypeptide binding]; other site 246197004491 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 246197004492 Helix-turn-helix domain; Region: HTH_18; pfam12833 246197004493 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246197004494 PS-10 peptidase S37; Region: Peptidase_S37; pfam05576 246197004495 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246197004496 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246197004497 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 246197004498 dimerization interface [polypeptide binding]; other site 246197004499 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246197004500 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246197004501 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 246197004502 Uncharacterized protein conserved in bacteria (DUF2084); Region: DUF2084; pfam09857 246197004503 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 246197004504 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 246197004505 catalytic residues [active] 246197004506 MAEBL; Provisional; Region: PTZ00121 246197004507 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 246197004508 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 246197004509 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 246197004510 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 246197004511 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 246197004512 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 246197004513 Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135 246197004514 Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135 246197004515 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 246197004516 Macrophage migration inhibitory factor (MIF); Region: MIF; pfam01187 246197004517 TPR repeat; Region: TPR_11; pfam13414 246197004518 Peptidase family M23; Region: Peptidase_M23; pfam01551 246197004519 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 246197004520 Fatty acid desaturase; Region: FA_desaturase; pfam00487 246197004521 putative di-iron ligands [ion binding]; other site 246197004522 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246197004523 Cytochrome P450; Region: p450; cl12078 246197004524 PLAT (Polycystin-1, Lipoxygenase, Alpha-Toxin) domain or LH2 (Lipoxygenase homology 2) domain. It consists of an eight stranded beta-barrel. The domain can be found in various domain architectures, in case of lipoxygenases, alpha toxin, lipases and...; Region: PLAT; cl00011 246197004525 Lipoxygenase; Region: Lipoxygenase; pfam00305 246197004526 Transthyretin-like family; Region: DUF290; pfam01060 246197004527 Lipoxygenase; Region: Lipoxygenase; pfam00305 246197004528 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 246197004529 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246197004530 DNA-binding site [nucleotide binding]; DNA binding site 246197004531 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246197004532 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246197004533 homodimer interface [polypeptide binding]; other site 246197004534 catalytic residue [active] 246197004535 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 246197004536 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 246197004537 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 246197004538 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246197004539 Coenzyme A binding pocket [chemical binding]; other site 246197004540 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 246197004541 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246197004542 catalytic loop [active] 246197004543 iron binding site [ion binding]; other site 246197004544 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 246197004545 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 246197004546 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 246197004547 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 246197004548 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 246197004549 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 246197004550 short chain dehydrogenase; Provisional; Region: PRK06172 246197004551 classical (c) SDRs; Region: SDR_c; cd05233 246197004552 NAD(P) binding site [chemical binding]; other site 246197004553 active site 246197004554 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 246197004555 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 246197004556 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 246197004557 active site 246197004558 catalytic tetrad [active] 246197004559 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246197004560 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246197004561 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 246197004562 putative effector binding pocket; other site 246197004563 putative dimerization interface [polypeptide binding]; other site 246197004564 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 246197004565 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 246197004566 catalytic Zn binding site [ion binding]; other site 246197004567 NAD(P) binding site [chemical binding]; other site 246197004568 structural Zn binding site [ion binding]; other site 246197004569 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 246197004570 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 246197004571 MarR family; Region: MarR_2; cl17246 246197004572 Galactose oxidase, central domain; Region: Kelch_3; cl02701 246197004573 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 246197004574 Kelch domain; Region: Kelch; smart00612 246197004575 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 246197004576 Kelch domain; Region: Kelch; smart00612 246197004577 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 246197004578 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 246197004579 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 246197004580 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 246197004581 Kelch domain; Region: Kelch; smart00612 246197004582 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 246197004583 Kelch domain; Region: Kelch; smart00612 246197004584 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 246197004585 Kelch domain; Region: Kelch; smart00612 246197004586 Integrase core domain; Region: rve_3; pfam13683 246197004587 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 246197004588 Transposase; Region: HTH_Tnp_1; pfam01527 246197004589 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 246197004590 RibD C-terminal domain; Region: RibD_C; cl17279 246197004591 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 246197004592 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 246197004593 NlpC/P60 family; Region: NLPC_P60; cl17555 246197004594 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 246197004595 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 246197004596 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 246197004597 putative ligand binding site [chemical binding]; other site 246197004598 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 246197004599 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 246197004600 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 246197004601 active site 246197004602 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 246197004603 putative catalytic residue [active] 246197004604 dimerization interface [polypeptide binding]; other site 246197004605 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 246197004606 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 246197004607 Integrase core domain; Region: rve_3; cl15866 246197004608 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 246197004609 HlyD family secretion protein; Region: HlyD_3; pfam13437 246197004610 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 246197004611 putative active site [active] 246197004612 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 246197004613 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246197004614 Walker A/P-loop; other site 246197004615 ATP binding site [chemical binding]; other site 246197004616 Q-loop/lid; other site 246197004617 ABC transporter signature motif; other site 246197004618 Walker B; other site 246197004619 D-loop; other site 246197004620 H-loop/switch region; other site 246197004621 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 246197004622 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246197004623 Walker A/P-loop; other site 246197004624 ATP binding site [chemical binding]; other site 246197004625 Q-loop/lid; other site 246197004626 ABC transporter signature motif; other site 246197004627 Walker B; other site 246197004628 D-loop; other site 246197004629 H-loop/switch region; other site 246197004630 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 246197004631 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 246197004632 active site 246197004633 ATP binding site [chemical binding]; other site 246197004634 substrate binding site [chemical binding]; other site 246197004635 Integrase core domain; Region: rve; pfam00665 246197004636 Integrase core domain; Region: rve_3; pfam13683 246197004637 HTH-like domain; Region: HTH_21; pfam13276 246197004638 Integrase core domain; Region: rve; pfam00665 246197004639 DDE superfamily endonuclease; Region: DDE_5; pfam13546 246197004640 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 246197004641 RibD C-terminal domain; Region: RibD_C; cl17279 246197004642 Protein of unknown function, DUF488; Region: DUF488; pfam04343 246197004643 Helix-turn-helix domain; Region: HTH_17; cl17695 246197004644 Predicted helicase [General function prediction only]; Region: COG4889 246197004645 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 246197004646 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246197004647 ATP binding site [chemical binding]; other site 246197004648 putative Mg++ binding site [ion binding]; other site 246197004649 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 246197004650 ATP-binding site [chemical binding]; other site 246197004651 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_1; cd10446 246197004652 GIY-YIG motif/motif A; other site 246197004653 putative active site [active] 246197004654 putative metal binding site [ion binding]; other site 246197004655 RDD family; Region: RDD; pfam06271 246197004656 HEAT repeats; Region: HEAT_2; pfam13646 246197004657 HEAT repeats; Region: HEAT_2; pfam13646 246197004658 HEAT repeats; Region: HEAT_2; pfam13646 246197004659 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 246197004660 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 246197004661 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 246197004662 active site 246197004663 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 246197004664 conserved hypothetical protein; Region: TIGR02270 246197004665 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 246197004666 putative active site pocket [active] 246197004667 dimerization interface [polypeptide binding]; other site 246197004668 putative catalytic residue [active] 246197004669 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 246197004670 putative active site pocket [active] 246197004671 dimerization interface [polypeptide binding]; other site 246197004672 putative catalytic residue [active] 246197004673 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 246197004674 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 246197004675 phage tail protein domain; Region: tail_TIGR02242 246197004676 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 246197004677 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 246197004678 Protein of unknown function (DUF511); Region: DUF511; cl01114 246197004679 Phage-related baseplate assembly protein; Region: Phage_base_V; cl17812 246197004680 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 246197004681 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 246197004682 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 246197004683 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 246197004684 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 246197004685 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 246197004686 Phage capsid family; Region: Phage_capsid; pfam05065 246197004687 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 246197004688 Phage-related protein [Function unknown]; Region: COG4695; cl01923 246197004689 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 246197004690 large terminase protein; Provisional; Region: 17; PHA02533 246197004691 Prophage antirepressor [Transcription]; Region: COG3617 246197004692 BRO family, N-terminal domain; Region: Bro-N; smart01040 246197004693 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 246197004694 active site 246197004695 DNA binding site [nucleotide binding] 246197004696 Int/Topo IB signature motif; other site 246197004697 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 246197004698 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 246197004699 active site 246197004700 catalytic site [active] 246197004701 substrate binding site [chemical binding]; other site 246197004702 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 246197004703 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 246197004704 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 246197004705 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 246197004706 protein-splicing catalytic site; other site 246197004707 thioester formation/cholesterol transfer; other site 246197004708 Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372 246197004709 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 246197004710 protein-splicing catalytic site; other site 246197004711 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 246197004712 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246197004713 putative Mg++ binding site [ion binding]; other site 246197004714 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246197004715 nucleotide binding region [chemical binding]; other site 246197004716 ATP-binding site [chemical binding]; other site 246197004717 Protein of unknown function (DUF2924); Region: DUF2924; pfam11149 246197004718 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 246197004719 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 246197004720 catalytic residues [active] 246197004721 catalytic nucleophile [active] 246197004722 Presynaptic Site I dimer interface [polypeptide binding]; other site 246197004723 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 246197004724 Synaptic Flat tetramer interface [polypeptide binding]; other site 246197004725 Synaptic Site I dimer interface [polypeptide binding]; other site 246197004726 DNA binding site [nucleotide binding] 246197004727 Recombinase; Region: Recombinase; pfam07508 246197004728 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 246197004729 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951 246197004730 Protein of unknown function (DUF2379); Region: DUF2379; pfam09543 246197004731 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197004732 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197004733 active site 246197004734 ATP binding site [chemical binding]; other site 246197004735 substrate binding site [chemical binding]; other site 246197004736 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246197004737 activation loop (A-loop); other site 246197004738 activation loop (A-loop); other site 246197004739 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 246197004740 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246197004741 non-specific DNA binding site [nucleotide binding]; other site 246197004742 salt bridge; other site 246197004743 sequence-specific DNA binding site [nucleotide binding]; other site 246197004744 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246197004745 non-specific DNA binding site [nucleotide binding]; other site 246197004746 salt bridge; other site 246197004747 sequence-specific DNA binding site [nucleotide binding]; other site 246197004748 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197004749 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197004750 active site 246197004751 ATP binding site [chemical binding]; other site 246197004752 substrate binding site [chemical binding]; other site 246197004753 activation loop (A-loop); other site 246197004754 Protein of unknown function (DUF2381); Region: DUF2381; pfam09544 246197004755 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 246197004756 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 246197004757 Restriction endonuclease; Region: Mrr_cat; pfam04471 246197004758 Predicted ATPase [General function prediction only]; Region: COG5293 246197004759 Uncharacterized protein conserved in bacteria (DUF2326); Region: DUF2326; pfam10088 246197004760 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 246197004761 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197004762 S-adenosylmethionine binding site [chemical binding]; other site 246197004763 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 246197004764 dimer interface [polypeptide binding]; other site 246197004765 catalytic triad [active] 246197004766 Beta-lactamase; Region: Beta-lactamase; pfam00144 246197004767 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 246197004768 UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773 246197004769 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 246197004770 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 246197004771 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 246197004772 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 246197004773 catalytic residues [active] 246197004774 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 246197004775 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 246197004776 active site 246197004777 dimerization interface [polypeptide binding]; other site 246197004778 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 246197004779 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 246197004780 SLBB domain; Region: SLBB; pfam10531 246197004781 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 246197004782 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 246197004783 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 246197004784 ligand binding site [chemical binding]; other site 246197004785 flexible hinge region; other site 246197004786 Gram-negative bacterial tonB protein; Region: TonB; cl10048 246197004787 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197004788 binding surface 246197004789 TPR motif; other site 246197004790 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197004791 TPR motif; other site 246197004792 binding surface 246197004793 TPR repeat; Region: TPR_11; pfam13414 246197004794 TPR repeat; Region: TPR_11; pfam13414 246197004795 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197004796 binding surface 246197004797 TPR motif; other site 246197004798 TPR repeat; Region: TPR_11; pfam13414 246197004799 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 246197004800 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 246197004801 binding surface 246197004802 TPR motif; other site 246197004803 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 246197004804 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197004805 binding surface 246197004806 TPR motif; other site 246197004807 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197004808 TPR motif; other site 246197004809 binding surface 246197004810 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 246197004811 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 246197004812 G1 box; other site 246197004813 GTP/Mg2+ binding site [chemical binding]; other site 246197004814 G2 box; other site 246197004815 Switch I region; other site 246197004816 G3 box; other site 246197004817 Switch II region; other site 246197004818 G4 box; other site 246197004819 G5 box; other site 246197004820 Roadblock/LC7 domain; Region: Robl_LC7; pfam03259 246197004821 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197004822 Cna protein B-type domain; Region: Cna_B_2; pfam13715 246197004823 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197004824 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197004825 active site 246197004826 ATP binding site [chemical binding]; other site 246197004827 substrate binding site [chemical binding]; other site 246197004828 activation loop (A-loop); other site 246197004829 recombination protein RecR; Reviewed; Region: recR; PRK00076 246197004830 RecR protein; Region: RecR; pfam02132 246197004831 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 246197004832 putative active site [active] 246197004833 putative metal-binding site [ion binding]; other site 246197004834 tetramer interface [polypeptide binding]; other site 246197004835 hypothetical protein; Validated; Region: PRK00153 246197004836 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 246197004837 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197004838 Walker A motif; other site 246197004839 ATP binding site [chemical binding]; other site 246197004840 Walker B motif; other site 246197004841 arginine finger; other site 246197004842 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 246197004843 Alg9-like mannosyltransferase family; Region: Glyco_transf_22; cl17751 246197004844 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 246197004845 nucleoside/Zn binding site; other site 246197004846 dimer interface [polypeptide binding]; other site 246197004847 catalytic motif [active] 246197004848 seryl-tRNA synthetase; Provisional; Region: PRK05431 246197004849 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 246197004850 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 246197004851 dimer interface [polypeptide binding]; other site 246197004852 active site 246197004853 motif 1; other site 246197004854 motif 2; other site 246197004855 motif 3; other site 246197004856 zinc-ribbon domain; Region: zinc_ribbon_4; pfam13717 246197004857 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 246197004858 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197004859 TPR motif; other site 246197004860 binding surface 246197004861 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197004862 binding surface 246197004863 TPR motif; other site 246197004864 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 246197004865 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197004866 TPR motif; other site 246197004867 binding surface 246197004868 TPR repeat; Region: TPR_11; pfam13414 246197004869 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197004870 binding surface 246197004871 TPR motif; other site 246197004872 TPR repeat; Region: TPR_11; pfam13414 246197004873 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197004874 TPR motif; other site 246197004875 binding surface 246197004876 TPR repeat; Region: TPR_11; pfam13414 246197004877 hypothetical protein; Provisional; Region: PRK07208 246197004878 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 246197004879 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 246197004880 Ligand binding site; other site 246197004881 Putative Catalytic site; other site 246197004882 DXD motif; other site 246197004883 Putative catalytic domain of uncharacterized bacterial polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_1; cd10940 246197004884 putative active site [active] 246197004885 putative catalytic site [active] 246197004886 putative Zn binding site [ion binding]; other site 246197004887 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 246197004888 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 246197004889 putative acyl-acceptor binding pocket; other site 246197004890 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 246197004891 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 246197004892 putative NAD(P) binding site [chemical binding]; other site 246197004893 active site 246197004894 putative substrate binding site [chemical binding]; other site 246197004895 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197004896 binding surface 246197004897 TPR motif; other site 246197004898 TPR repeat; Region: TPR_11; pfam13414 246197004899 TPR repeat; Region: TPR_11; pfam13414 246197004900 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197004901 TPR motif; other site 246197004902 binding surface 246197004903 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 246197004904 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197004905 binding surface 246197004906 TPR motif; other site 246197004907 TPR repeat; Region: TPR_11; pfam13414 246197004908 Tetratricopeptide repeat; Region: TPR_16; pfam13432 246197004909 DEAD-like helicases superfamily; Region: DEXDc; smart00487 246197004910 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246197004911 ATP binding site [chemical binding]; other site 246197004912 putative Mg++ binding site [ion binding]; other site 246197004913 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246197004914 nucleotide binding region [chemical binding]; other site 246197004915 ATP-binding site [chemical binding]; other site 246197004916 HRDC domain; Region: HRDC; pfam00570 246197004917 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 246197004918 hypothetical protein; Reviewed; Region: PRK00024 246197004919 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 246197004920 MPN+ (JAMM) motif; other site 246197004921 Zinc-binding site [ion binding]; other site 246197004922 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 246197004923 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 246197004924 ligand binding site [chemical binding]; other site 246197004925 flexible hinge region; other site 246197004926 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 246197004927 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 246197004928 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 246197004929 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 246197004930 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 246197004931 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246197004932 catalytic residue [active] 246197004933 molybdenum cofactor biosynthesis protein MoaC; Provisional; Region: moaC; PRK09364 246197004934 trimer interface [polypeptide binding]; other site 246197004935 dimer interface [polypeptide binding]; other site 246197004936 putative active site [active] 246197004937 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 246197004938 Tetratricopeptide repeat; Region: TPR_9; pfam13371 246197004939 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 246197004940 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 246197004941 CoA binding domain; Region: CoA_binding_2; pfam13380 246197004942 Peptidase S8 family domain, uncharacterized subfamily 11; Region: Peptidases_S8_11; cd04843 246197004943 putative active site [active] 246197004944 putative catalytic triad [active] 246197004945 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 246197004946 active site 246197004947 nucleophile elbow; other site 246197004948 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246197004949 dimerization interface [polypeptide binding]; other site 246197004950 putative DNA binding site [nucleotide binding]; other site 246197004951 putative Zn2+ binding site [ion binding]; other site 246197004952 Methyltransferase domain; Region: Methyltransf_23; pfam13489 246197004953 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197004954 S-adenosylmethionine binding site [chemical binding]; other site 246197004955 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 246197004956 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 246197004957 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 246197004958 substrate binding pocket [chemical binding]; other site 246197004959 dimer interface [polypeptide binding]; other site 246197004960 inhibitor binding site; inhibition site 246197004961 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 246197004962 B12 binding site [chemical binding]; other site 246197004963 cobalt ligand [ion binding]; other site 246197004964 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 246197004965 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 246197004966 This domain contains a conserved N-terminal (F/Y)RG motif. It is functionally uncharacterised; Region: FRG; smart00901 246197004967 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 246197004968 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 246197004969 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 246197004970 minor groove reading motif; other site 246197004971 helix-hairpin-helix signature motif; other site 246197004972 substrate binding pocket [chemical binding]; other site 246197004973 active site 246197004974 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 246197004975 DNA binding and oxoG recognition site [nucleotide binding] 246197004976 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 246197004977 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246197004978 NAD(P) binding site [chemical binding]; other site 246197004979 active site 246197004980 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 246197004981 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 246197004982 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 246197004983 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 246197004984 putative ATP binding site [chemical binding]; other site 246197004985 putative substrate interface [chemical binding]; other site 246197004986 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 246197004987 active site 246197004988 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 246197004989 Maf-like protein; Region: Maf; pfam02545 246197004990 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 246197004991 active site 246197004992 dimer interface [polypeptide binding]; other site 246197004993 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197004994 TPR motif; other site 246197004995 binding surface 246197004996 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197004997 TPR motif; other site 246197004998 binding surface 246197004999 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 246197005000 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 246197005001 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 246197005002 putative RNA binding site [nucleotide binding]; other site 246197005003 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197005004 S-adenosylmethionine binding site [chemical binding]; other site 246197005005 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 246197005006 Part of AAA domain; Region: AAA_19; pfam13245 246197005007 Family description; Region: UvrD_C_2; pfam13538 246197005008 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 246197005009 23S rRNA interface [nucleotide binding]; other site 246197005010 L3 interface [polypeptide binding]; other site 246197005011 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 246197005012 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 246197005013 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 246197005014 ATP binding site [chemical binding]; other site 246197005015 Walker B motif; other site 246197005016 recombination regulator RecX; Reviewed; Region: recX; PRK00117 246197005017 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 246197005018 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197005019 binding surface 246197005020 TPR repeat; Region: TPR_11; pfam13414 246197005021 TPR motif; other site 246197005022 Tetratricopeptide repeat; Region: TPR_12; pfam13424 246197005023 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197005024 binding surface 246197005025 TPR motif; other site 246197005026 TPR repeat; Region: TPR_11; pfam13414 246197005027 Tetratricopeptide repeat; Region: TPR_16; pfam13432 246197005028 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246197005029 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 246197005030 phosphopeptide binding site; other site 246197005031 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 246197005032 selenophosphate synthetase; Provisional; Region: PRK00943 246197005033 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 246197005034 dimerization interface [polypeptide binding]; other site 246197005035 putative ATP binding site [chemical binding]; other site 246197005036 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 246197005037 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 246197005038 active site 246197005039 metal binding site [ion binding]; metal-binding site 246197005040 ribonuclease PH; Reviewed; Region: rph; PRK00173 246197005041 Ribonuclease PH; Region: RNase_PH_bact; cd11362 246197005042 hexamer interface [polypeptide binding]; other site 246197005043 active site 246197005044 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 246197005045 active site 246197005046 dimerization interface [polypeptide binding]; other site 246197005047 RecT family; Region: RecT; pfam03837 246197005048 trigger factor; Region: tig; TIGR00115 246197005049 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 246197005050 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 246197005051 Clp protease; Region: CLP_protease; pfam00574 246197005052 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 246197005053 oligomer interface [polypeptide binding]; other site 246197005054 active site residues [active] 246197005055 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 246197005056 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 246197005057 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197005058 Walker A motif; other site 246197005059 ATP binding site [chemical binding]; other site 246197005060 Walker B motif; other site 246197005061 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 246197005062 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 246197005063 Protein of unknown function (DUF3979); Region: DUF3979; pfam13141 246197005064 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 246197005065 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 246197005066 Found in ATP-dependent protease La (LON); Region: LON; smart00464 246197005067 Found in ATP-dependent protease La (LON); Region: LON; smart00464 246197005068 Mediator complex protein; Region: Med11; pfam10280 246197005069 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197005070 Walker A motif; other site 246197005071 ATP binding site [chemical binding]; other site 246197005072 Walker B motif; other site 246197005073 arginine finger; other site 246197005074 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 246197005075 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 246197005076 peptide binding site [polypeptide binding]; other site 246197005077 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 246197005078 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 246197005079 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246197005080 dimer interface [polypeptide binding]; other site 246197005081 conserved gate region; other site 246197005082 putative PBP binding loops; other site 246197005083 ABC-ATPase subunit interface; other site 246197005084 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246197005085 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 246197005086 dimer interface [polypeptide binding]; other site 246197005087 conserved gate region; other site 246197005088 putative PBP binding loops; other site 246197005089 ABC-ATPase subunit interface; other site 246197005090 Response regulator receiver domain; Region: Response_reg; pfam00072 246197005091 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197005092 active site 246197005093 phosphorylation site [posttranslational modification] 246197005094 intermolecular recognition site; other site 246197005095 dimerization interface [polypeptide binding]; other site 246197005096 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 246197005097 BolA-like protein; Region: BolA; pfam01722 246197005098 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 246197005099 putative GSH binding site [chemical binding]; other site 246197005100 catalytic residues [active] 246197005101 Protein of unknown function (DUF2914); Region: DUF2914; pfam11141 246197005102 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 246197005103 proline aminopeptidase P II; Provisional; Region: PRK10879 246197005104 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 246197005105 active site 246197005106 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 246197005107 RNA methyltransferase, RsmE family; Region: TIGR00046 246197005108 DTW domain; Region: DTW; pfam03942 246197005109 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 246197005110 FecR protein; Region: FecR; pfam04773 246197005111 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 246197005112 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246197005113 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 246197005114 DNA binding residues [nucleotide binding] 246197005115 AIDA autotransporter-like protein ShdA; Provisional; Region: PRK15319 246197005116 Methyltransferase domain; Region: Methyltransf_26; pfam13659 246197005117 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 246197005118 Fe-S cluster binding site [ion binding]; other site 246197005119 active site 246197005120 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 246197005121 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246197005122 substrate binding site [chemical binding]; other site 246197005123 oxyanion hole (OAH) forming residues; other site 246197005124 trimer interface [polypeptide binding]; other site 246197005125 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 246197005126 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 246197005127 homodimer interface [polypeptide binding]; other site 246197005128 substrate-cofactor binding pocket; other site 246197005129 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246197005130 catalytic residue [active] 246197005131 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 246197005132 putative active site [active] 246197005133 putative catalytic site [active] 246197005134 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 246197005135 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 246197005136 dimer interface [polypeptide binding]; other site 246197005137 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246197005138 catalytic residue [active] 246197005139 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 246197005140 Phosphotransferase enzyme family; Region: APH; pfam01636 246197005141 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 246197005142 substrate binding site [chemical binding]; other site 246197005143 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 246197005144 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 246197005145 Substrate binding site; other site 246197005146 metal-binding site 246197005147 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 246197005148 active site 246197005149 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 246197005150 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 246197005151 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 246197005152 HSP70 interaction site [polypeptide binding]; other site 246197005153 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197005154 binding surface 246197005155 TPR motif; other site 246197005156 Response regulator receiver domain; Region: Response_reg; pfam00072 246197005157 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197005158 active site 246197005159 phosphorylation site [posttranslational modification] 246197005160 intermolecular recognition site; other site 246197005161 dimerization interface [polypeptide binding]; other site 246197005162 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 246197005163 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197005164 binding surface 246197005165 Tetratricopeptide repeat; Region: TPR_16; pfam13432 246197005166 TPR motif; other site 246197005167 TPR repeat; Region: TPR_11; pfam13414 246197005168 UGMP family protein; Validated; Region: PRK09604 246197005169 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 246197005170 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 246197005171 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197005172 S-adenosylmethionine binding site [chemical binding]; other site 246197005173 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 246197005174 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 246197005175 Substrate-binding site [chemical binding]; other site 246197005176 Substrate specificity [chemical binding]; other site 246197005177 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 246197005178 oligomerization interface [polypeptide binding]; other site 246197005179 active site 246197005180 metal binding site [ion binding]; metal-binding site 246197005181 Pantoate-beta-alanine ligase; Region: PanC; cd00560 246197005182 pantoate--beta-alanine ligase; Region: panC; TIGR00018 246197005183 active site 246197005184 ATP-binding site [chemical binding]; other site 246197005185 pantoate-binding site; other site 246197005186 HXXH motif; other site 246197005187 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 246197005188 SmpB-tmRNA interface; other site 246197005189 Stringent starvation protein B; Region: SspB; cl01120 246197005190 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197005191 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197005192 active site 246197005193 ATP binding site [chemical binding]; other site 246197005194 substrate binding site [chemical binding]; other site 246197005195 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246197005196 substrate binding site [chemical binding]; other site 246197005197 activation loop (A-loop); other site 246197005198 activation loop (A-loop); other site 246197005199 PEGA domain; Region: PEGA; pfam08308 246197005200 Protein of unknown function (DUF971); Region: DUF971; pfam06155 246197005201 Cache domain; Region: Cache_1; pfam02743 246197005202 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246197005203 dimerization interface [polypeptide binding]; other site 246197005204 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 246197005205 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 246197005206 Zn2+ binding site [ion binding]; other site 246197005207 Mg2+ binding site [ion binding]; other site 246197005208 LysM domain; Region: LysM; pfam01476 246197005209 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 246197005210 Interdomain contacts; other site 246197005211 Cytokine receptor motif; other site 246197005212 FecR protein; Region: FecR; pfam04773 246197005213 nitrilase; Region: PLN02798 246197005214 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 246197005215 putative active site [active] 246197005216 catalytic triad [active] 246197005217 dimer interface [polypeptide binding]; other site 246197005218 ribosome maturation protein RimP; Reviewed; Region: PRK00092 246197005219 Sm and related proteins; Region: Sm_like; cl00259 246197005220 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 246197005221 putative oligomer interface [polypeptide binding]; other site 246197005222 putative RNA binding site [nucleotide binding]; other site 246197005223 NusA N-terminal domain; Region: NusA_N; pfam08529 246197005224 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 246197005225 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 246197005226 RNA binding site [nucleotide binding]; other site 246197005227 homodimer interface [polypeptide binding]; other site 246197005228 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 246197005229 G-X-X-G motif; other site 246197005230 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 246197005231 G-X-X-G motif; other site 246197005232 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 246197005233 putative RNA binding cleft [nucleotide binding]; other site 246197005234 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 246197005235 translation initiation factor IF-2; Region: IF-2; TIGR00487 246197005236 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 246197005237 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 246197005238 G1 box; other site 246197005239 putative GEF interaction site [polypeptide binding]; other site 246197005240 GTP/Mg2+ binding site [chemical binding]; other site 246197005241 Switch I region; other site 246197005242 G2 box; other site 246197005243 G3 box; other site 246197005244 Switch II region; other site 246197005245 G4 box; other site 246197005246 G5 box; other site 246197005247 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 246197005248 Translation-initiation factor 2; Region: IF-2; pfam11987 246197005249 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 246197005250 Protein of unknown function (DUF503); Region: DUF503; pfam04456 246197005251 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 246197005252 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 246197005253 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 246197005254 RNA binding site [nucleotide binding]; other site 246197005255 active site 246197005256 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 246197005257 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 246197005258 16S/18S rRNA binding site [nucleotide binding]; other site 246197005259 S13e-L30e interaction site [polypeptide binding]; other site 246197005260 25S rRNA binding site [nucleotide binding]; other site 246197005261 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 246197005262 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 246197005263 RNase E interface [polypeptide binding]; other site 246197005264 trimer interface [polypeptide binding]; other site 246197005265 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 246197005266 RNase E interface [polypeptide binding]; other site 246197005267 trimer interface [polypeptide binding]; other site 246197005268 active site 246197005269 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 246197005270 putative nucleic acid binding region [nucleotide binding]; other site 246197005271 G-X-X-G motif; other site 246197005272 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 246197005273 RNA binding site [nucleotide binding]; other site 246197005274 domain interface; other site 246197005275 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 246197005276 Peptidase family M23; Region: Peptidase_M23; pfam01551 246197005277 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 246197005278 trimer interface [polypeptide binding]; other site 246197005279 active site 246197005280 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197005281 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197005282 active site 246197005283 ATP binding site [chemical binding]; other site 246197005284 substrate binding site [chemical binding]; other site 246197005285 activation loop (A-loop); other site 246197005286 Uncharacterized conserved protein [Function unknown]; Region: COG1262 246197005287 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 246197005288 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 246197005289 adenylosuccinate lyase; Provisional; Region: PRK07492 246197005290 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 246197005291 tetramer interface [polypeptide binding]; other site 246197005292 active site 246197005293 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 246197005294 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 246197005295 ATP binding site [chemical binding]; other site 246197005296 active site 246197005297 substrate binding site [chemical binding]; other site 246197005298 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 246197005299 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 246197005300 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 246197005301 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 246197005302 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 246197005303 protein binding site [polypeptide binding]; other site 246197005304 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 246197005305 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 246197005306 catalytic residues [active] 246197005307 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197005308 binding surface 246197005309 Tetratricopeptide repeat; Region: TPR_16; pfam13432 246197005310 TPR motif; other site 246197005311 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 246197005312 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 246197005313 ligand binding site [chemical binding]; other site 246197005314 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 246197005315 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 246197005316 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 246197005317 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 246197005318 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 246197005319 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 246197005320 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 246197005321 conserved hypothetical protein; Region: TIGR02270 246197005322 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 246197005323 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 246197005324 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 246197005325 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 246197005326 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 246197005327 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 246197005328 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 246197005329 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 246197005330 putative active site [active] 246197005331 putative NTP binding site [chemical binding]; other site 246197005332 putative nucleic acid binding site [nucleotide binding]; other site 246197005333 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 246197005334 Integrase core domain; Region: rve_3; pfam13683 246197005335 Transposase; Region: HTH_Tnp_1; cl17663 246197005336 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 246197005337 HYR domain; Region: HYR; pfam02494 246197005338 HYR domain; Region: HYR; pfam02494 246197005339 HYR domain; Region: HYR; pfam02494 246197005340 Domain of unknown function (DUF336); Region: DUF336; pfam03928 246197005341 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 246197005342 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197005343 Walker A motif; other site 246197005344 ATP binding site [chemical binding]; other site 246197005345 Walker B motif; other site 246197005346 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 246197005347 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 246197005348 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246197005349 insertion element IS2 transposase InsD; Provisional; Region: PRK14702 246197005350 HTH-like domain; Region: HTH_21; pfam13276 246197005351 Integrase core domain; Region: rve; pfam00665 246197005352 Integrase core domain; Region: rve_3; pfam13683 246197005353 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 246197005354 Transposase; Region: HTH_Tnp_1; pfam01527 246197005355 Astacin (Peptidase family M12A); Region: Astacin; pfam01400 246197005356 Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to...; Region: ZnMc_astacin_like; cd04280 246197005357 active site 246197005358 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187 246197005359 PKC phosphorylation site [posttranslational modification]; other site 246197005360 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246197005361 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246197005362 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 246197005363 dimerization interface [polypeptide binding]; other site 246197005364 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 246197005365 Beta-lactamase; Region: Beta-lactamase; pfam00144 246197005366 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 246197005367 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 246197005368 active site 246197005369 catalytic tetrad [active] 246197005370 Deoxyhypusine synthase; Region: DS; cl00826 246197005371 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 246197005372 Endonuclease I; Region: Endonuclease_1; cl01003 246197005373 Methyltransferase domain; Region: Methyltransf_32; pfam13679 246197005374 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246197005375 NAD(P) binding site [chemical binding]; other site 246197005376 active site 246197005377 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 246197005378 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246197005379 PQQ-like domain; Region: PQQ_2; pfam13360 246197005380 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246197005381 ATP binding site [chemical binding]; other site 246197005382 putative Mg++ binding site [ion binding]; other site 246197005383 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 246197005384 nucleotide binding region [chemical binding]; other site 246197005385 Helix-turn-helix domain; Region: HTH_18; pfam12833 246197005386 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 246197005387 Beta-lactamase; Region: Beta-lactamase; pfam00144 246197005388 Uncharacterized protein conserved in bacteria (DUF2239); Region: DUF2239; pfam09998 246197005389 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 246197005390 Prostaglandin dehydrogenases; Region: PGDH; cd05288 246197005391 NAD(P) binding site [chemical binding]; other site 246197005392 substrate binding site [chemical binding]; other site 246197005393 dimer interface [polypeptide binding]; other site 246197005394 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 246197005395 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 246197005396 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197005397 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197005398 active site 246197005399 ATP binding site [chemical binding]; other site 246197005400 substrate binding site [chemical binding]; other site 246197005401 activation loop (A-loop); other site 246197005402 PEGA domain; Region: PEGA; pfam08308 246197005403 PEGA domain; Region: PEGA; pfam08308 246197005404 FHA domain; Region: FHA; pfam00498 246197005405 phosphopeptide binding site; other site 246197005406 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 246197005407 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197005408 Walker A motif; other site 246197005409 ATP binding site [chemical binding]; other site 246197005410 Walker B motif; other site 246197005411 arginine finger; other site 246197005412 Cna protein B-type domain; Region: Cna_B; pfam05738 246197005413 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197005414 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197005415 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197005416 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197005417 IPT/TIG domain; Region: TIG; pfam01833 246197005418 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 246197005419 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 246197005420 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 246197005421 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 246197005422 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 246197005423 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 246197005424 Domain of unknown function (DUF1993); Region: DUF1993; pfam09351 246197005425 Transposase; Region: HTH_Tnp_1; pfam01527 246197005426 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 246197005427 Integrase core domain; Region: rve; pfam00665 246197005428 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 246197005429 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 246197005430 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197005431 Walker A motif; other site 246197005432 ATP binding site [chemical binding]; other site 246197005433 Walker B motif; other site 246197005434 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 246197005435 Interdomain contacts; other site 246197005436 Cytokine receptor motif; other site 246197005437 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 246197005438 protein-splicing catalytic site; other site 246197005439 thioester formation/cholesterol transfer; other site 246197005440 HNH endonuclease; Region: HNH_2; pfam13391 246197005441 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 246197005442 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197005443 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197005444 active site 246197005445 ATP binding site [chemical binding]; other site 246197005446 substrate binding site [chemical binding]; other site 246197005447 activation loop (A-loop); other site 246197005448 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246197005449 active site 246197005450 ATP binding site [chemical binding]; other site 246197005451 substrate binding site [chemical binding]; other site 246197005452 activation loop (A-loop); other site 246197005453 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 246197005454 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 246197005455 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 246197005456 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 246197005457 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 246197005458 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 246197005459 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 246197005460 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 246197005461 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246197005462 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246197005463 DNA binding residues [nucleotide binding] 246197005464 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 246197005465 Uncharacterized conserved protein [Function unknown]; Region: COG2128 246197005466 B12 binding domain; Region: B12-binding; pfam02310 246197005467 B12 binding site [chemical binding]; other site 246197005468 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 246197005469 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 246197005470 catalytic residues [active] 246197005471 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 246197005472 binding surface 246197005473 TPR motif; other site 246197005474 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 246197005475 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 246197005476 DoxX-like family; Region: DoxX_2; pfam13564 246197005477 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246197005478 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 246197005479 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 246197005480 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 246197005481 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246197005482 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 246197005483 CHAT domain; Region: CHAT; pfam12770 246197005484 BioY family; Region: BioY; pfam02632 246197005485 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 246197005486 Cytochrome c552; Region: Cytochrom_C552; pfam02335 246197005487 cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153 246197005488 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 246197005489 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 246197005490 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246197005491 putative substrate translocation pore; other site 246197005492 Helix-turn-helix domain; Region: HTH_18; pfam12833 246197005493 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246197005494 Cupin domain; Region: Cupin_2; pfam07883 246197005495 Helix-turn-helix domain; Region: HTH_18; pfam12833 246197005496 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246197005497 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 246197005498 EamA-like transporter family; Region: EamA; pfam00892 246197005499 Prolyl 4-hydroxylase alpha subunit homologues; Region: P4Hc; smart00702 246197005500 AAA domain; Region: AAA_33; pfam13671 246197005501 AAA domain; Region: AAA_17; pfam13207 246197005502 Dual-action HEIGH metallo-peptidase; Region: Peptidase_M57; pfam12388 246197005503 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 246197005504 putative catalytic site [active] 246197005505 putative metal binding site [ion binding]; other site 246197005506 putative phosphate binding site [ion binding]; other site 246197005507 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 246197005508 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246197005509 active site 246197005510 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246197005511 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 246197005512 active site 246197005513 metal binding site [ion binding]; metal-binding site 246197005514 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 246197005515 active site 246197005516 catalytic triad [active] 246197005517 oxyanion hole [active] 246197005518 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 246197005519 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 246197005520 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 246197005521 homodimer interface [polypeptide binding]; other site 246197005522 NADP binding site [chemical binding]; other site 246197005523 substrate binding site [chemical binding]; other site 246197005524 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 246197005525 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 246197005526 heme binding pocket [chemical binding]; other site 246197005527 heme ligand [chemical binding]; other site 246197005528 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 246197005529 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 246197005530 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246197005531 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246197005532 DNA binding residues [nucleotide binding] 246197005533 dimerization interface [polypeptide binding]; other site 246197005534 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 246197005535 dinuclear metal binding motif [ion binding]; other site 246197005536 Pirin; Region: Pirin; pfam02678 246197005537 Pirin-related protein [General function prediction only]; Region: COG1741 246197005538 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 246197005539 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246197005540 putative substrate translocation pore; other site 246197005541 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 246197005542 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246197005543 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 246197005544 NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530 246197005545 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 246197005546 active site 246197005547 metal binding site [ion binding]; metal-binding site 246197005548 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 246197005549 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 246197005550 catalytic triad [active] 246197005551 dimer interface [polypeptide binding]; other site 246197005552 Isochorismatase family; Region: Isochorismatase; pfam00857 246197005553 conserved cis-peptide bond; other site 246197005554 Isochorismatase family; Region: Isochorismatase; pfam00857 246197005555 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 246197005556 catalytic triad [active] 246197005557 dimer interface [polypeptide binding]; other site 246197005558 conserved cis-peptide bond; other site 246197005559 Predicted flavoprotein [General function prediction only]; Region: COG0431 246197005560 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 246197005561 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 246197005562 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 246197005563 putative NAD(P) binding site [chemical binding]; other site 246197005564 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 246197005565 ATP binding site [chemical binding]; other site 246197005566 putative Mg++ binding site [ion binding]; other site 246197005567 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246197005568 nucleotide binding region [chemical binding]; other site 246197005569 ATP-binding site [chemical binding]; other site 246197005570 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 246197005571 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197005572 S-adenosylmethionine binding site [chemical binding]; other site 246197005573 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 246197005574 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 246197005575 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 246197005576 dimer interface [polypeptide binding]; other site 246197005577 putative CheW interface [polypeptide binding]; other site 246197005578 Methyltransferase domain; Region: Methyltransf_31; pfam13847 246197005579 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197005580 S-adenosylmethionine binding site [chemical binding]; other site 246197005581 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 246197005582 FAD binding domain; Region: FAD_binding_4; pfam01565 246197005583 Berberine and berberine like; Region: BBE; pfam08031 246197005584 FOG: WD40 repeat [General function prediction only]; Region: COG2319 246197005585 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 246197005586 structural tetrad; other site 246197005587 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 246197005588 structural tetrad; other site 246197005589 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 246197005590 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 246197005591 Walker A/P-loop; other site 246197005592 ATP binding site [chemical binding]; other site 246197005593 Q-loop/lid; other site 246197005594 ABC transporter signature motif; other site 246197005595 Walker B; other site 246197005596 D-loop; other site 246197005597 H-loop/switch region; other site 246197005598 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 246197005599 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246197005600 dimer interface [polypeptide binding]; other site 246197005601 conserved gate region; other site 246197005602 putative PBP binding loops; other site 246197005603 ABC-ATPase subunit interface; other site 246197005604 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 246197005605 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 246197005606 Phosphagen (guanidino) kinases mostly found in eukaryotes; Region: eukaryotic_phosphagen_kinases; cd07931 246197005607 phosphagen binding site; other site 246197005608 ADP binding site [chemical binding]; other site 246197005609 substrate specificity loop; other site 246197005610 PS-10 peptidase S37; Region: Peptidase_S37; pfam05576 246197005611 Domain of unknown function (DUF4419); Region: DUF4419; pfam14388 246197005612 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 246197005613 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197005614 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197005615 active site 246197005616 ATP binding site [chemical binding]; other site 246197005617 substrate binding site [chemical binding]; other site 246197005618 activation loop (A-loop); other site 246197005619 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 246197005620 catalytic residues [active] 246197005621 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 246197005622 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246197005623 phosphopeptide binding site; other site 246197005624 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 246197005625 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246197005626 ATP binding site [chemical binding]; other site 246197005627 putative Mg++ binding site [ion binding]; other site 246197005628 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246197005629 nucleotide binding region [chemical binding]; other site 246197005630 ATP-binding site [chemical binding]; other site 246197005631 TPR repeat; Region: TPR_11; pfam13414 246197005632 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 246197005633 TPR repeat; Region: TPR_11; pfam13414 246197005634 putative cation:proton antiport protein; Provisional; Region: PRK10669 246197005635 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 246197005636 TrkA-N domain; Region: TrkA_N; pfam02254 246197005637 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 246197005638 B12 binding site [chemical binding]; other site 246197005639 cobalt ligand [ion binding]; other site 246197005640 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 246197005641 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 246197005642 membrane ATPase/protein kinase; Provisional; Region: PRK09435 246197005643 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 246197005644 Walker A; other site 246197005645 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 246197005646 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 246197005647 active site 246197005648 substrate binding site [chemical binding]; other site 246197005649 coenzyme B12 binding site [chemical binding]; other site 246197005650 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 246197005651 B12 binding site [chemical binding]; other site 246197005652 cobalt ligand [ion binding]; other site 246197005653 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 246197005654 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 246197005655 heterodimer interface [polypeptide binding]; other site 246197005656 substrate interaction site [chemical binding]; other site 246197005657 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 246197005658 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 246197005659 RNA/DNA hybrid binding site [nucleotide binding]; other site 246197005660 active site 246197005661 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 246197005662 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 246197005663 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 246197005664 catalytic residues [active] 246197005665 Nitronate monooxygenase; Region: NMO; pfam03060 246197005666 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 246197005667 FMN binding site [chemical binding]; other site 246197005668 substrate binding site [chemical binding]; other site 246197005669 putative catalytic residue [active] 246197005670 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 246197005671 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 246197005672 FtsX-like permease family; Region: FtsX; pfam02687 246197005673 FtsX-like permease family; Region: FtsX; pfam02687 246197005674 GTPase RsgA; Reviewed; Region: PRK01889 246197005675 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 246197005676 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 246197005677 GTPase/Zn-binding domain interface [polypeptide binding]; other site 246197005678 GTP/Mg2+ binding site [chemical binding]; other site 246197005679 G4 box; other site 246197005680 G5 box; other site 246197005681 G1 box; other site 246197005682 Switch I region; other site 246197005683 G2 box; other site 246197005684 G3 box; other site 246197005685 Switch II region; other site 246197005686 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 246197005687 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197005688 S-adenosylmethionine binding site [chemical binding]; other site 246197005689 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 246197005690 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 246197005691 Zn binding site [ion binding]; other site 246197005692 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 246197005693 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 246197005694 nucleotide binding site [chemical binding]; other site 246197005695 substrate binding site [chemical binding]; other site 246197005696 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 246197005697 dimer interface [polypeptide binding]; other site 246197005698 putative threonine allosteric regulatory site; other site 246197005699 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 246197005700 putative threonine allosteric regulatory site; other site 246197005701 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 246197005702 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 246197005703 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 246197005704 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 246197005705 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 246197005706 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 246197005707 putative NAD(P) binding site [chemical binding]; other site 246197005708 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 246197005709 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 246197005710 FMN binding site [chemical binding]; other site 246197005711 active site 246197005712 catalytic residues [active] 246197005713 substrate binding site [chemical binding]; other site 246197005714 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197005715 TPR motif; other site 246197005716 binding surface 246197005717 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 246197005718 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 246197005719 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 246197005720 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 246197005721 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 246197005722 active site 246197005723 Zn binding site [ion binding]; other site 246197005724 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 246197005725 dimer interface [polypeptide binding]; other site 246197005726 substrate binding site [chemical binding]; other site 246197005727 ATP binding site [chemical binding]; other site 246197005728 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 246197005729 Interdomain contacts; other site 246197005730 Cytokine receptor motif; other site 246197005731 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 246197005732 Interdomain contacts; other site 246197005733 Cytokine receptor motif; other site 246197005734 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 246197005735 Glyco_18 domain; Region: Glyco_18; smart00636 246197005736 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 246197005737 active site 246197005738 hypothetical protein; Provisional; Region: PRK08262 246197005739 M20 Peptidase, carboxypeptidase yscS; Region: M20_yscS; cd05674 246197005740 metal binding site [ion binding]; metal-binding site 246197005741 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 246197005742 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 246197005743 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 246197005744 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 246197005745 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 246197005746 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 246197005747 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 246197005748 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 246197005749 PA14 domain; Region: PA14; cl08459 246197005750 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 246197005751 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 246197005752 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 246197005753 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 246197005754 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 246197005755 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246197005756 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246197005757 putative substrate translocation pore; other site 246197005758 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 246197005759 O-methyltransferase; Region: Methyltransf_2; pfam00891 246197005760 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 246197005761 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 246197005762 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 246197005763 putative dimer interface [polypeptide binding]; other site 246197005764 putative anticodon binding site; other site 246197005765 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 246197005766 homodimer interface [polypeptide binding]; other site 246197005767 motif 1; other site 246197005768 motif 2; other site 246197005769 active site 246197005770 motif 3; other site 246197005771 CotH protein; Region: CotH; pfam08757 246197005772 Protein of unknown function (DUF2743); Region: DUF2743; pfam10899 246197005773 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246197005774 Cytochrome P450; Region: p450; pfam00067 246197005775 TonB C terminal; Region: TonB_2; pfam13103 246197005776 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 246197005777 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 246197005778 Penicillin-insensitive murein endopeptidase; Region: Peptidase_M74; cl01538 246197005779 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 246197005780 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 246197005781 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 246197005782 helicase 45; Provisional; Region: PTZ00424 246197005783 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 246197005784 ATP binding site [chemical binding]; other site 246197005785 putative Mg++ binding site [ion binding]; other site 246197005786 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246197005787 nucleotide binding region [chemical binding]; other site 246197005788 ATP-binding site [chemical binding]; other site 246197005789 PIN domain; Region: PIN_3; pfam13470 246197005790 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 246197005791 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 246197005792 heme-binding residues [chemical binding]; other site 246197005793 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 246197005794 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 246197005795 putative NAD(P) binding site [chemical binding]; other site 246197005796 RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248 246197005797 ATP binding site [chemical binding]; other site 246197005798 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 246197005799 EF-hand domain pair; Region: EF_hand_5; pfam13499 246197005800 Ca2+ binding site [ion binding]; other site 246197005801 PAS domain; Region: PAS_8; pfam13188 246197005802 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 246197005803 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246197005804 putative active site [active] 246197005805 heme pocket [chemical binding]; other site 246197005806 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197005807 dimer interface [polypeptide binding]; other site 246197005808 phosphorylation site [posttranslational modification] 246197005809 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197005810 ATP binding site [chemical binding]; other site 246197005811 Mg2+ binding site [ion binding]; other site 246197005812 G-X-G motif; other site 246197005813 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 246197005814 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197005815 active site 246197005816 phosphorylation site [posttranslational modification] 246197005817 intermolecular recognition site; other site 246197005818 dimerization interface [polypeptide binding]; other site 246197005819 Response regulator receiver domain; Region: Response_reg; pfam00072 246197005820 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197005821 active site 246197005822 phosphorylation site [posttranslational modification] 246197005823 intermolecular recognition site; other site 246197005824 dimerization interface [polypeptide binding]; other site 246197005825 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 246197005826 putative binding surface; other site 246197005827 active site 246197005828 glutathione reductase; Validated; Region: PRK06116 246197005829 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 246197005830 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 246197005831 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 246197005832 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 246197005833 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 246197005834 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 246197005835 Beta-lactamase; Region: Beta-lactamase; pfam00144 246197005836 Protein of unknown function (DUF504); Region: DUF504; cl00661 246197005837 Surface antigen; Region: Bac_surface_Ag; pfam01103 246197005838 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 246197005839 pantothenate kinase; Provisional; Region: PRK05439 246197005840 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 246197005841 ATP-binding site [chemical binding]; other site 246197005842 CoA-binding site [chemical binding]; other site 246197005843 Mg2+-binding site [ion binding]; other site 246197005844 Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102 246197005845 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 246197005846 NAD(P) binding site [chemical binding]; other site 246197005847 catalytic residues [active] 246197005848 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 246197005849 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 246197005850 Putative ammonia monooxygenase; Region: AmoA; pfam05145 246197005851 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 246197005852 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 246197005853 NAD-dependent deacetylase; Provisional; Region: PRK05333 246197005854 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 246197005855 type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713 246197005856 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 246197005857 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 246197005858 Methyltransferase domain; Region: Methyltransf_23; pfam13489 246197005859 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197005860 S-adenosylmethionine binding site [chemical binding]; other site 246197005861 sulfite reductase subunit beta; Provisional; Region: PRK13504 246197005862 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 246197005863 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 246197005864 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 246197005865 Flavodoxin; Region: Flavodoxin_1; pfam00258 246197005866 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 246197005867 FAD binding pocket [chemical binding]; other site 246197005868 FAD binding motif [chemical binding]; other site 246197005869 catalytic residues [active] 246197005870 NAD binding pocket [chemical binding]; other site 246197005871 phosphate binding motif [ion binding]; other site 246197005872 beta-alpha-beta structure motif; other site 246197005873 GTPases - Sulfate adenylate transferase subunit 1 [Inorganic ion transport and metabolism]; Region: CysN; COG2895 246197005874 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 246197005875 CysD dimerization site [polypeptide binding]; other site 246197005876 G1 box; other site 246197005877 putative GEF interaction site [polypeptide binding]; other site 246197005878 GTP/Mg2+ binding site [chemical binding]; other site 246197005879 Switch I region; other site 246197005880 G2 box; other site 246197005881 G3 box; other site 246197005882 Switch II region; other site 246197005883 G4 box; other site 246197005884 G5 box; other site 246197005885 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 246197005886 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 246197005887 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 246197005888 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 246197005889 Active Sites [active] 246197005890 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 246197005891 active site 246197005892 SAM binding site [chemical binding]; other site 246197005893 homodimer interface [polypeptide binding]; other site 246197005894 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 246197005895 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 246197005896 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 246197005897 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 246197005898 Active Sites [active] 246197005899 Domain of unknown function (DUF2383); Region: DUF2383; pfam09537 246197005900 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG3687 246197005901 Predicted metal-dependent hydrolase; Region: Metal_hydrol; pfam10118 246197005902 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 246197005903 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 246197005904 dimerization interface [polypeptide binding]; other site 246197005905 ATP binding site [chemical binding]; other site 246197005906 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 246197005907 dimerization interface [polypeptide binding]; other site 246197005908 ATP binding site [chemical binding]; other site 246197005909 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 246197005910 putative active site [active] 246197005911 catalytic triad [active] 246197005912 methionine sulfoxide reductase B; Provisional; Region: PRK00222 246197005913 SelR domain; Region: SelR; pfam01641 246197005914 FOG: CBS domain [General function prediction only]; Region: COG0517 246197005915 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 246197005916 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 246197005917 active site 246197005918 dimer interface [polypeptide binding]; other site 246197005919 motif 1; other site 246197005920 motif 2; other site 246197005921 motif 3; other site 246197005922 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 246197005923 anticodon binding site; other site 246197005924 OPT oligopeptide transporter protein; Region: OPT; cl14607 246197005925 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 246197005926 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 246197005927 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 246197005928 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 246197005929 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme MccE; Region: PLPDE_III_MccE_like; cd06841 246197005930 dimer interface [polypeptide binding]; other site 246197005931 active site 246197005932 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 246197005933 catalytic residues [active] 246197005934 substrate binding site [chemical binding]; other site 246197005935 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 246197005936 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 246197005937 active site 246197005938 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 246197005939 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 246197005940 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 246197005941 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 246197005942 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 246197005943 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 246197005944 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246197005945 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 246197005946 putative ADP-binding pocket [chemical binding]; other site 246197005947 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 246197005948 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 246197005949 active site 246197005950 HIGH motif; other site 246197005951 nucleotide binding site [chemical binding]; other site 246197005952 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 246197005953 KMSKS motif; other site 246197005954 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 246197005955 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 246197005956 Beta-lactamase; Region: Beta-lactamase; pfam00144 246197005957 TPR repeat; Region: TPR_11; pfam13414 246197005958 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197005959 TPR motif; other site 246197005960 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 246197005961 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246197005962 Coenzyme A binding pocket [chemical binding]; other site 246197005963 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246197005964 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 246197005965 putative active site [active] 246197005966 heme pocket [chemical binding]; other site 246197005967 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246197005968 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 246197005969 putative active site [active] 246197005970 heme pocket [chemical binding]; other site 246197005971 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246197005972 putative active site [active] 246197005973 heme pocket [chemical binding]; other site 246197005974 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 246197005975 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 246197005976 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197005977 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197005978 dimer interface [polypeptide binding]; other site 246197005979 phosphorylation site [posttranslational modification] 246197005980 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197005981 ATP binding site [chemical binding]; other site 246197005982 Mg2+ binding site [ion binding]; other site 246197005983 G-X-G motif; other site 246197005984 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 246197005985 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 246197005986 active site 246197005987 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 246197005988 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 246197005989 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 246197005990 active site 246197005991 SUMO-1 interface [polypeptide binding]; other site 246197005992 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 246197005993 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 246197005994 putative substrate binding site [chemical binding]; other site 246197005995 putative ATP binding site [chemical binding]; other site 246197005996 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246197005997 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 246197005998 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 246197005999 active site 246197006000 Uncharacterized protein containing double-stranded beta helix domain [Function unknown]; Region: COG4297 246197006001 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 246197006002 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246197006003 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 246197006004 active site 246197006005 Protein of unknown function (DUF423); Region: DUF423; pfam04241 246197006006 SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Region: SET; smart00317 246197006007 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246197006008 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246197006009 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 246197006010 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 246197006011 active site 246197006012 metal binding site [ion binding]; metal-binding site 246197006013 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 246197006014 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 246197006015 Ligand binding site; other site 246197006016 DXD motif; other site 246197006017 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 246197006018 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 246197006019 PAS domain S-box; Region: sensory_box; TIGR00229 246197006020 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246197006021 putative active site [active] 246197006022 heme pocket [chemical binding]; other site 246197006023 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 246197006024 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246197006025 putative active site [active] 246197006026 heme pocket [chemical binding]; other site 246197006027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197006028 ATP binding site [chemical binding]; other site 246197006029 Mg2+ binding site [ion binding]; other site 246197006030 G-X-G motif; other site 246197006031 Response regulator receiver domain; Region: Response_reg; pfam00072 246197006032 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197006033 active site 246197006034 phosphorylation site [posttranslational modification] 246197006035 intermolecular recognition site; other site 246197006036 dimerization interface [polypeptide binding]; other site 246197006037 Protein of unknown function (DUF2378); Region: DUF2378; pfam09536 246197006038 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 246197006039 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246197006040 Walker A/P-loop; other site 246197006041 ATP binding site [chemical binding]; other site 246197006042 Q-loop/lid; other site 246197006043 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246197006044 ABC transporter signature motif; other site 246197006045 Walker B; other site 246197006046 D-loop; other site 246197006047 H-loop/switch region; other site 246197006048 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246197006049 Walker A/P-loop; other site 246197006050 ATP binding site [chemical binding]; other site 246197006051 Q-loop/lid; other site 246197006052 ABC transporter signature motif; other site 246197006053 Walker B; other site 246197006054 D-loop; other site 246197006055 H-loop/switch region; other site 246197006056 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246197006057 Walker A/P-loop; other site 246197006058 ATP binding site [chemical binding]; other site 246197006059 Q-loop/lid; other site 246197006060 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 246197006061 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246197006062 ABC transporter signature motif; other site 246197006063 Walker B; other site 246197006064 D-loop; other site 246197006065 H-loop/switch region; other site 246197006066 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246197006067 Walker A/P-loop; other site 246197006068 ATP binding site [chemical binding]; other site 246197006069 Q-loop/lid; other site 246197006070 ABC transporter signature motif; other site 246197006071 Walker B; other site 246197006072 D-loop; other site 246197006073 H-loop/switch region; other site 246197006074 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 246197006075 catalytic residues [active] 246197006076 dimer interface [polypeptide binding]; other site 246197006077 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 246197006078 Putative zinc-finger; Region: zf-HC2; pfam13490 246197006079 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 246197006080 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246197006081 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 246197006082 Protein of unknown function (DUF2378); Region: DUF2378; cl15288 246197006083 Uncharacterized conserved protein [Function unknown]; Region: COG1944 246197006084 YcaO-like family; Region: YcaO; pfam02624 246197006085 Uncharacterized conserved protein [Function unknown]; Region: COG3482 246197006086 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197006087 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197006088 active site 246197006089 ATP binding site [chemical binding]; other site 246197006090 substrate binding site [chemical binding]; other site 246197006091 activation loop (A-loop); other site 246197006092 Myxococcus xanthus paralogous family TIGR02268; Region: TIGR02268 246197006093 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 246197006094 DNA methylase; Region: N6_N4_Mtase; pfam01555 246197006095 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 246197006096 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 246197006097 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 246197006098 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 246197006099 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 246197006100 oligopeptide transporter, OPT superfamily; Region: OPT_sfam; TIGR00728 246197006101 OPT oligopeptide transporter protein; Region: OPT; pfam03169 246197006102 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 246197006103 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246197006104 Walker A/P-loop; other site 246197006105 ATP binding site [chemical binding]; other site 246197006106 Q-loop/lid; other site 246197006107 ABC transporter signature motif; other site 246197006108 Walker B; other site 246197006109 D-loop; other site 246197006110 H-loop/switch region; other site 246197006111 ABC transporter; Region: ABC_tran_2; pfam12848 246197006112 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 246197006113 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 246197006114 elongation factor G; Reviewed; Region: PRK12740 246197006115 G1 box; other site 246197006116 putative GEF interaction site [polypeptide binding]; other site 246197006117 GTP/Mg2+ binding site [chemical binding]; other site 246197006118 Switch I region; other site 246197006119 G2 box; other site 246197006120 G3 box; other site 246197006121 Switch II region; other site 246197006122 G4 box; other site 246197006123 G5 box; other site 246197006124 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091 246197006125 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 246197006126 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_C; cd04097 246197006127 SnoaL-like domain; Region: SnoaL_2; pfam12680 246197006128 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 246197006129 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 246197006130 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 246197006131 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 246197006132 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 246197006133 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 246197006134 RNA binding surface [nucleotide binding]; other site 246197006135 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 246197006136 active site 246197006137 uracil binding [chemical binding]; other site 246197006138 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 246197006139 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 246197006140 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 246197006141 MG2 domain; Region: A2M_N; pfam01835 246197006142 Alpha-2-macroglobulin family; Region: A2M; pfam00207 246197006143 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 246197006144 surface patch; other site 246197006145 thioester region; other site 246197006146 Catalytic domain of vertebrate phospholipase D6 and similar proteins; Region: PLDc_vPLD6_like; cd09171 246197006147 PLD-like domain; Region: PLDc_2; pfam13091 246197006148 putative active site [active] 246197006149 catalytic site [active] 246197006150 penicillin-binding protein 1C; Region: PBP_1c; TIGR02073 246197006151 Transglycosylase; Region: Transgly; pfam00912 246197006152 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 246197006153 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 246197006154 CotH protein; Region: CotH; pfam08757 246197006155 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 246197006156 Uncharacterized conserved protein [Function unknown]; Region: COG5276 246197006157 LVIVD repeat; Region: LVIVD; pfam08309 246197006158 LVIVD repeat; Region: LVIVD; pfam08309 246197006159 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 246197006160 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 246197006161 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 246197006162 FtsX-like permease family; Region: FtsX; pfam02687 246197006163 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 246197006164 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 246197006165 FtsX-like permease family; Region: FtsX; pfam02687 246197006166 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 246197006167 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 246197006168 Walker A/P-loop; other site 246197006169 ATP binding site [chemical binding]; other site 246197006170 Q-loop/lid; other site 246197006171 ABC transporter signature motif; other site 246197006172 Walker B; other site 246197006173 D-loop; other site 246197006174 H-loop/switch region; other site 246197006175 Predicted transcriptional regulators [Transcription]; Region: COG1510 246197006176 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 246197006177 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 246197006178 TPR repeat; Region: TPR_11; pfam13414 246197006179 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197006180 binding surface 246197006181 TPR motif; other site 246197006182 TPR repeat; Region: TPR_11; pfam13414 246197006183 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 246197006184 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246197006185 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246197006186 DNA binding residues [nucleotide binding] 246197006187 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 246197006188 transcription termination factor Rho; Provisional; Region: PRK12678 246197006189 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 246197006190 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 246197006191 Flagellar assembly protein FliH; Region: FliH; pfam02108 246197006192 type III secretion apparatus H+-transporting two-sector ATPase; Region: III_secr_ATP; TIGR02546 246197006193 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 246197006194 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 246197006195 Walker A motif/ATP binding site; other site 246197006196 Walker B motif; other site 246197006197 Peptidase S46; Region: Peptidase_S46; pfam10459 246197006198 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 246197006199 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 246197006200 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 246197006201 type III secretion system protein; Reviewed; Region: PRK09617 246197006202 Flagellar biosynthesis pathway, component FliQ [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliQ; COG1987 246197006203 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 246197006204 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 246197006205 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 246197006206 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 246197006207 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 246197006208 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197006209 TPR motif; other site 246197006210 binding surface 246197006211 Domain of Unknown Function (DUF1521); Region: DUF1521; pfam07481 246197006212 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 246197006213 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197006214 binding surface 246197006215 TPR motif; other site 246197006216 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197006217 TPR motif; other site 246197006218 binding surface 246197006219 TPR repeat; Region: TPR_11; pfam13414 246197006220 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197006221 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 246197006222 FHIPEP family; Region: FHIPEP; pfam00771 246197006223 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246197006224 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 246197006225 phosphopeptide binding site; other site 246197006226 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 246197006227 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246197006228 phosphopeptide binding site; other site 246197006229 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197006230 TPR motif; other site 246197006231 TPR repeat; Region: TPR_11; pfam13414 246197006232 binding surface 246197006233 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197006234 binding surface 246197006235 TPR repeat; Region: TPR_11; pfam13414 246197006236 TPR motif; other site 246197006237 TPR repeat; Region: TPR_11; pfam13414 246197006238 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197006239 TPR motif; other site 246197006240 binding surface 246197006241 OmpW family; Region: OmpW; cl17427 246197006242 RDD family; Region: RDD; pfam06271 246197006243 TLC ATP/ADP transporter; Region: TLC; cl03940 246197006244 HEAT repeats; Region: HEAT_2; pfam13646 246197006245 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 246197006246 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 246197006247 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 246197006248 ligand binding site [chemical binding]; other site 246197006249 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 246197006250 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 246197006251 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 246197006252 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 246197006253 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197006254 binding surface 246197006255 TPR motif; other site 246197006256 Integral membrane protein DUF95; Region: DUF95; pfam01944 246197006257 Inorganic pyrophosphatase; Region: Pyrophosphatase; pfam00719 246197006258 dimer interface [polypeptide binding]; other site 246197006259 substrate binding site [chemical binding]; other site 246197006260 metal binding sites [ion binding]; metal-binding site 246197006261 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 246197006262 Protein of unknown function DUF58; Region: DUF58; pfam01882 246197006263 MoxR-like ATPases [General function prediction only]; Region: COG0714 246197006264 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197006265 Walker A motif; other site 246197006266 ATP binding site [chemical binding]; other site 246197006267 Walker B motif; other site 246197006268 arginine finger; other site 246197006269 transcription termination factor Rho; Provisional; Region: PRK12608 246197006270 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 246197006271 Walker A motif; other site 246197006272 ATP binding site [chemical binding]; other site 246197006273 Walker B motif; other site 246197006274 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 246197006275 tandem repeat interface [polypeptide binding]; other site 246197006276 oligomer interface [polypeptide binding]; other site 246197006277 active site residues [active] 246197006278 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 246197006279 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 246197006280 tandem repeat interface [polypeptide binding]; other site 246197006281 oligomer interface [polypeptide binding]; other site 246197006282 active site residues [active] 246197006283 PEGA domain; Region: PEGA; pfam08308 246197006284 PEGA domain; Region: PEGA; pfam08308 246197006285 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 246197006286 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197006287 Mg2+ binding site [ion binding]; other site 246197006288 G-X-G motif; other site 246197006289 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 246197006290 anchoring element; other site 246197006291 dimer interface [polypeptide binding]; other site 246197006292 ATP binding site [chemical binding]; other site 246197006293 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 246197006294 active site 246197006295 putative metal-binding site [ion binding]; other site 246197006296 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 246197006297 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 246197006298 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 246197006299 CAP-like domain; other site 246197006300 active site 246197006301 primary dimer interface [polypeptide binding]; other site 246197006302 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 246197006303 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 246197006304 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 246197006305 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 246197006306 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 246197006307 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 246197006308 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 246197006309 Protein of unknown function (Gmx_para_CXXCG); Region: Gmx_para_CXXCG; pfam09535 246197006310 Predicted lipoprotein of unknown function (DUF2380); Region: DUF2380; pfam09533 246197006311 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 246197006312 Peptidase S46; Region: Peptidase_S46; pfam10459 246197006313 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 246197006314 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 246197006315 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246197006316 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246197006317 DNA binding residues [nucleotide binding] 246197006318 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246197006319 phosphopeptide binding site; other site 246197006320 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 246197006321 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246197006322 phosphopeptide binding site; other site 246197006323 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197006324 Walker A motif; other site 246197006325 ATP binding site [chemical binding]; other site 246197006326 Walker B motif; other site 246197006327 arginine finger; other site 246197006328 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 246197006329 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 246197006330 Type II secretion system (T2SS), protein M; Region: T2SM; cl01222 246197006331 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 246197006332 Cell division protein FtsA; Region: FtsA; pfam14450 246197006333 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 246197006334 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 246197006335 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 246197006336 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 246197006337 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 246197006338 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 246197006339 type II secretion system protein F; Region: GspF; TIGR02120 246197006340 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 246197006341 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 246197006342 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 246197006343 type II secretion system protein E; Region: type_II_gspE; TIGR02533 246197006344 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 246197006345 Walker A motif; other site 246197006346 ATP binding site [chemical binding]; other site 246197006347 Walker B motif; other site 246197006348 type II secretion system protein D; Region: type_II_gspD; TIGR02517 246197006349 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 246197006350 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 246197006351 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 246197006352 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 246197006353 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 246197006354 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 246197006355 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197006356 active site 246197006357 phosphorylation site [posttranslational modification] 246197006358 intermolecular recognition site; other site 246197006359 dimerization interface [polypeptide binding]; other site 246197006360 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197006361 Walker A motif; other site 246197006362 ATP binding site [chemical binding]; other site 246197006363 Walker B motif; other site 246197006364 arginine finger; other site 246197006365 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 246197006366 ParB-like nuclease domain; Region: ParB; smart00470 246197006367 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 246197006368 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 246197006369 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246197006370 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 246197006371 phosphopeptide binding site; other site 246197006372 TPR repeat; Region: TPR_11; pfam13414 246197006373 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197006374 binding surface 246197006375 TPR motif; other site 246197006376 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 246197006377 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 246197006378 ligand binding site [chemical binding]; other site 246197006379 flexible hinge region; other site 246197006380 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 246197006381 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 246197006382 ligand binding site [chemical binding]; other site 246197006383 flexible hinge region; other site 246197006384 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197006385 TPR motif; other site 246197006386 binding surface 246197006387 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 246197006388 Homoserine Kinase, type II. Homoserine kinase is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: HomoserineK_II; cd05153 246197006389 putative active site [active] 246197006390 putative substrate binding site [chemical binding]; other site 246197006391 ATP binding site [chemical binding]; other site 246197006392 SnoaL-like domain; Region: SnoaL_3; pfam13474 246197006393 SnoaL-like domain; Region: SnoaL_2; pfam12680 246197006394 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 246197006395 Myxococcus xanthus paralogous domain TIGR02266; Region: gmx_TIGR02266 246197006396 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 246197006397 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 246197006398 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 246197006399 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 246197006400 2-enoyl thioester reductase (ETR) like proteins, child 1; Region: ETR_like_1; cd08291 246197006401 NADP binding site [chemical binding]; other site 246197006402 dimer interface [polypeptide binding]; other site 246197006403 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 246197006404 putative deacylase active site [active] 246197006405 phosphoribosylaminoimidazole carboxylase, PurK protein; Region: purK; TIGR01161 246197006406 ATP-grasp domain; Region: ATP-grasp; pfam02222 246197006407 AIR carboxylase; Region: AIRC; pfam00731 246197006408 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 246197006409 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 246197006410 acyl-activating enzyme (AAE) consensus motif; other site 246197006411 putative AMP binding site [chemical binding]; other site 246197006412 putative active site [active] 246197006413 putative CoA binding site [chemical binding]; other site 246197006414 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 246197006415 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 246197006416 metal ion-dependent adhesion site (MIDAS); other site 246197006417 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 246197006418 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246197006419 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246197006420 putative substrate translocation pore; other site 246197006421 putative phosphate acyltransferase; Provisional; Region: PRK05331 246197006422 Uncharacterized conserved protein [Function unknown]; Region: COG4850 246197006423 poly(A) polymerase; Region: pcnB; TIGR01942 246197006424 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 246197006425 active site 246197006426 NTP binding site [chemical binding]; other site 246197006427 metal binding triad [ion binding]; metal-binding site 246197006428 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 246197006429 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 246197006430 active site 246197006431 DNA polymerase IV; Validated; Region: PRK02406 246197006432 DNA binding site [nucleotide binding] 246197006433 Uncharacterized conserved protein [Function unknown]; Region: COG0432 246197006434 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 246197006435 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 246197006436 RNA binding surface [nucleotide binding]; other site 246197006437 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 246197006438 active site 246197006439 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246197006440 active site 246197006441 ATP binding site [chemical binding]; other site 246197006442 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197006443 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246197006444 substrate binding site [chemical binding]; other site 246197006445 activation loop (A-loop); other site 246197006446 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246197006447 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197006448 active site 246197006449 ATP binding site [chemical binding]; other site 246197006450 substrate binding site [chemical binding]; other site 246197006451 activation loop (A-loop); other site 246197006452 PEGA domain; Region: PEGA; pfam08308 246197006453 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 246197006454 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 246197006455 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 246197006456 Predicted transcriptional regulator [Transcription]; Region: COG2378 246197006457 HTH domain; Region: HTH_11; pfam08279 246197006458 WYL domain; Region: WYL; pfam13280 246197006459 short chain dehydrogenase; Provisional; Region: PRK08303 246197006460 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246197006461 NAD(P) binding site [chemical binding]; other site 246197006462 active site 246197006463 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 246197006464 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 246197006465 catalytic residue [active] 246197006466 putative FPP diphosphate binding site; other site 246197006467 putative FPP binding hydrophobic cleft; other site 246197006468 dimer interface [polypeptide binding]; other site 246197006469 putative IPP diphosphate binding site; other site 246197006470 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 246197006471 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 246197006472 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 246197006473 active site 246197006474 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 246197006475 protein binding site [polypeptide binding]; other site 246197006476 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 246197006477 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 246197006478 protein binding site [polypeptide binding]; other site 246197006479 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 246197006480 putative substrate binding region [chemical binding]; other site 246197006481 Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797 246197006482 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 246197006483 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 246197006484 Glycoprotease family; Region: Peptidase_M22; pfam00814 246197006485 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 246197006486 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 246197006487 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 246197006488 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 246197006489 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 246197006490 MoaE interaction surface [polypeptide binding]; other site 246197006491 MoeB interaction surface [polypeptide binding]; other site 246197006492 thiocarboxylated glycine; other site 246197006493 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 246197006494 MoaE homodimer interface [polypeptide binding]; other site 246197006495 MoaD interaction [polypeptide binding]; other site 246197006496 active site residues [active] 246197006497 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246197006498 putative substrate translocation pore; other site 246197006499 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 246197006500 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 246197006501 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 246197006502 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 246197006503 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 246197006504 nudix motif; other site 246197006505 acetyl-CoA synthetase; Provisional; Region: PRK00174 246197006506 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 246197006507 active site 246197006508 CoA binding site [chemical binding]; other site 246197006509 acyl-activating enzyme (AAE) consensus motif; other site 246197006510 AMP binding site [chemical binding]; other site 246197006511 acetate binding site [chemical binding]; other site 246197006512 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 246197006513 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 246197006514 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246197006515 catalytic residue [active] 246197006516 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 246197006517 catalytic core [active] 246197006518 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 246197006519 RNA/DNA hybrid binding site [nucleotide binding]; other site 246197006520 active site 246197006521 B-box zinc finger; Region: zf-B_box; pfam00643 246197006522 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 246197006523 M61 glycyl aminopeptidase; Region: Peptidase_M61; pfam05299 246197006524 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 246197006525 protein binding site [polypeptide binding]; other site 246197006526 ribosomal RNA small subunit methyltransferase RsmB; Region: rsmB; TIGR00563 246197006527 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197006528 S-adenosylmethionine binding site [chemical binding]; other site 246197006529 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 246197006530 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 246197006531 active site 246197006532 metal binding site [ion binding]; metal-binding site 246197006533 Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089 246197006534 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 246197006535 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 246197006536 TMP-binding site; other site 246197006537 ATP-binding site [chemical binding]; other site 246197006538 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 246197006539 putative active site; other site 246197006540 putative metal binding residues [ion binding]; other site 246197006541 signature motif; other site 246197006542 putative triphosphate binding site [ion binding]; other site 246197006543 Filamin/ABP280 repeat; Region: Filamin; pfam00630 246197006544 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246197006545 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197006546 active site 246197006547 ATP binding site [chemical binding]; other site 246197006548 substrate binding site [chemical binding]; other site 246197006549 activation loop (A-loop); other site 246197006550 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 246197006551 active site residue [active] 246197006552 molybdopterin biosynthesis protein MoeB; Validated; Region: PRK08762 246197006553 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 246197006554 active site residue [active] 246197006555 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 246197006556 ATP binding site [chemical binding]; other site 246197006557 substrate interface [chemical binding]; other site 246197006558 Iron-sulfur cluster assembly accessory protein; Region: TIGR00049 246197006559 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 246197006560 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 246197006561 AAA domain; Region: AAA_18; pfam13238 246197006562 Substrate-binding site [chemical binding]; other site 246197006563 Substrate specificity [chemical binding]; other site 246197006564 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 246197006565 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 246197006566 putative active site [active] 246197006567 catalytic site [active] 246197006568 putative metal binding site [ion binding]; other site 246197006569 Bacterial Ig-like domain; Region: Big_5; pfam13205 246197006570 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246197006571 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197006572 active site 246197006573 ATP binding site [chemical binding]; other site 246197006574 substrate binding site [chemical binding]; other site 246197006575 activation loop (A-loop); other site 246197006576 Protein of unknown function DUF45; Region: DUF45; cl00636 246197006577 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197006578 S-adenosylmethionine binding site [chemical binding]; other site 246197006579 quinolinate synthetase; Provisional; Region: PRK09375 246197006580 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197006581 S-adenosylmethionine binding site [chemical binding]; other site 246197006582 Centrosome localisation domain of PPC89; Region: Cep57_CLD_2; pfam14197 246197006583 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197006584 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197006585 ATP binding site [chemical binding]; other site 246197006586 Mg2+ binding site [ion binding]; other site 246197006587 G-X-G motif; other site 246197006588 Response regulator receiver domain; Region: Response_reg; pfam00072 246197006589 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197006590 active site 246197006591 phosphorylation site [posttranslational modification] 246197006592 intermolecular recognition site; other site 246197006593 dimerization interface [polypeptide binding]; other site 246197006594 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197006595 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197006596 dimer interface [polypeptide binding]; other site 246197006597 phosphorylation site [posttranslational modification] 246197006598 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197006599 ATP binding site [chemical binding]; other site 246197006600 Mg2+ binding site [ion binding]; other site 246197006601 G-X-G motif; other site 246197006602 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 246197006603 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246197006604 putative substrate translocation pore; other site 246197006605 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246197006606 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246197006607 POT family; Region: PTR2; cl17359 246197006608 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 246197006609 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 246197006610 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 246197006611 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 246197006612 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 246197006613 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 246197006614 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 246197006615 DNA binding site [nucleotide binding] 246197006616 active site 246197006617 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 246197006618 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 246197006619 AlkA N-terminal domain; Region: AlkA_N; pfam06029 246197006620 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 246197006621 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 246197006622 minor groove reading motif; other site 246197006623 helix-hairpin-helix signature motif; other site 246197006624 substrate binding pocket [chemical binding]; other site 246197006625 active site 246197006626 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 246197006627 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 246197006628 active site 246197006629 metal binding site [ion binding]; metal-binding site 246197006630 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 246197006631 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 246197006632 active site 246197006633 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246197006634 Coenzyme A binding pocket [chemical binding]; other site 246197006635 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 246197006636 Family description; Region: UvrD_C_2; pfam13538 246197006637 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 246197006638 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 246197006639 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 246197006640 GDP-binding site [chemical binding]; other site 246197006641 ACT binding site; other site 246197006642 IMP binding site; other site 246197006643 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197006644 binding surface 246197006645 TPR motif; other site 246197006646 TPR repeat; Region: TPR_11; pfam13414 246197006647 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197006648 binding surface 246197006649 TPR motif; other site 246197006650 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 246197006651 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246197006652 phosphopeptide binding site; other site 246197006653 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 246197006654 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_3; cd09620 246197006655 putative ligand binding site [chemical binding]; other site 246197006656 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 246197006657 Competence protein; Region: Competence; pfam03772 246197006658 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 246197006659 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 246197006660 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246197006661 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 246197006662 phosphopeptide binding site; other site 246197006663 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 246197006664 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 246197006665 active site 246197006666 HIGH motif; other site 246197006667 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 246197006668 KMSKS motif; other site 246197006669 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 246197006670 tRNA binding surface [nucleotide binding]; other site 246197006671 anticodon binding site; other site 246197006672 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 246197006673 PA_M28_1_2: Protease-associated (PA) domain, peptidase family M28, subfamily-1, subgroup 2. A subgroup of PA-domain containing proteins belonging to the peptidase family M28. Family M28 contains aminopeptidases and carboxypeptidases, and has co-catalytic...; Region: PA_M28_1_2; cd04821 246197006674 PA/protease or protease-like domain interface [polypeptide binding]; other site 246197006675 M28 Zn-Peptidases containing a PA domain insert; Region: M28_like_PA_1; cd05660 246197006676 Peptidase family M28; Region: Peptidase_M28; pfam04389 246197006677 metal binding site [ion binding]; metal-binding site 246197006678 excinuclease ABC subunit B; Provisional; Region: PRK05298 246197006679 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246197006680 ATP binding site [chemical binding]; other site 246197006681 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246197006682 nucleotide binding region [chemical binding]; other site 246197006683 ATP-binding site [chemical binding]; other site 246197006684 Ultra-violet resistance protein B; Region: UvrB; pfam12344 246197006685 UvrB/uvrC motif; Region: UVR; pfam02151 246197006686 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 246197006687 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 246197006688 GIY-YIG motif/motif A; other site 246197006689 active site 246197006690 catalytic site [active] 246197006691 putative DNA binding site [nucleotide binding]; other site 246197006692 metal binding site [ion binding]; metal-binding site 246197006693 UvrB/uvrC motif; Region: UVR; pfam02151 246197006694 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 246197006695 Protein of unknown function (DUF507); Region: DUF507; pfam04368 246197006696 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 246197006697 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 246197006698 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 246197006699 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 246197006700 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 246197006701 catalytic residue [active] 246197006702 Maf-like protein; Region: Maf; pfam02545 246197006703 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 246197006704 active site 246197006705 dimer interface [polypeptide binding]; other site 246197006706 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 246197006707 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 246197006708 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 246197006709 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 246197006710 metal binding site [ion binding]; metal-binding site 246197006711 active site 246197006712 I-site; other site 246197006713 SurA N-terminal domain; Region: SurA_N_3; cl07813 246197006714 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 246197006715 rod shape-determining protein MreC; Provisional; Region: PRK13922 246197006716 rod shape-determining protein MreC; Region: MreC; pfam04085 246197006717 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 246197006718 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 246197006719 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 246197006720 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 246197006721 PilZ domain; Region: PilZ; pfam07238 246197006722 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 246197006723 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 246197006724 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 246197006725 catalytic residues [active] 246197006726 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 246197006727 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 246197006728 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 246197006729 tRNA; other site 246197006730 putative tRNA binding site [nucleotide binding]; other site 246197006731 putative NADP binding site [chemical binding]; other site 246197006732 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 246197006733 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 246197006734 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 246197006735 domain interfaces; other site 246197006736 active site 246197006737 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 246197006738 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 246197006739 active site 246197006740 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 246197006741 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 246197006742 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 246197006743 Walker A motif; other site 246197006744 ATP binding site [chemical binding]; other site 246197006745 Walker B motif; other site 246197006746 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 246197006747 generic binding surface I; other site 246197006748 generic binding surface II; other site 246197006749 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 246197006750 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 246197006751 active site 246197006752 metal binding site [ion binding]; metal-binding site 246197006753 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 246197006754 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 246197006755 nudix motif; other site 246197006756 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 246197006757 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246197006758 putative substrate translocation pore; other site 246197006759 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 246197006760 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 246197006761 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 246197006762 tetramer interface [polypeptide binding]; other site 246197006763 TPP-binding site [chemical binding]; other site 246197006764 heterodimer interface [polypeptide binding]; other site 246197006765 phosphorylation loop region [posttranslational modification] 246197006766 pyruvate dehydrogenase subunit beta; Validated; Region: PRK09212 246197006767 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 246197006768 alpha subunit interface [polypeptide binding]; other site 246197006769 TPP binding site [chemical binding]; other site 246197006770 heterodimer interface [polypeptide binding]; other site 246197006771 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 246197006772 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 246197006773 E3 interaction surface; other site 246197006774 lipoyl attachment site [posttranslational modification]; other site 246197006775 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 246197006776 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 246197006777 E3 interaction surface; other site 246197006778 lipoyl attachment site [posttranslational modification]; other site 246197006779 e3 binding domain; Region: E3_binding; pfam02817 246197006780 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 246197006781 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 246197006782 Response regulator receiver domain; Region: Response_reg; pfam00072 246197006783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197006784 active site 246197006785 phosphorylation site [posttranslational modification] 246197006786 intermolecular recognition site; other site 246197006787 dimerization interface [polypeptide binding]; other site 246197006788 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197006789 ATP binding site [chemical binding]; other site 246197006790 Mg2+ binding site [ion binding]; other site 246197006791 G-X-G motif; other site 246197006792 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197006793 active site 246197006794 phosphorylation site [posttranslational modification] 246197006795 intermolecular recognition site; other site 246197006796 dimerization interface [polypeptide binding]; other site 246197006797 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 246197006798 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 246197006799 HIGH motif; other site 246197006800 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 246197006801 active site 246197006802 KMSKS motif; other site 246197006803 Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279 246197006804 active site 246197006805 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 246197006806 active site 246197006807 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 246197006808 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 246197006809 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197006810 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197006811 active site 246197006812 ATP binding site [chemical binding]; other site 246197006813 substrate binding site [chemical binding]; other site 246197006814 activation loop (A-loop); other site 246197006815 PEGA domain; Region: PEGA; pfam08308 246197006816 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 246197006817 CheW-like domain; Region: CheW; pfam01584 246197006818 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 246197006819 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 246197006820 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197006821 binding surface 246197006822 TPR motif; other site 246197006823 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 246197006824 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 246197006825 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246197006826 dimerization interface [polypeptide binding]; other site 246197006827 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 246197006828 dimer interface [polypeptide binding]; other site 246197006829 putative CheW interface [polypeptide binding]; other site 246197006830 Response regulator receiver domain; Region: Response_reg; pfam00072 246197006831 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197006832 active site 246197006833 phosphorylation site [posttranslational modification] 246197006834 intermolecular recognition site; other site 246197006835 dimerization interface [polypeptide binding]; other site 246197006836 CheW-like domain; Region: CheW; pfam01584 246197006837 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 246197006838 putative binding surface; other site 246197006839 active site 246197006840 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197006841 ATP binding site [chemical binding]; other site 246197006842 Mg2+ binding site [ion binding]; other site 246197006843 G-X-G motif; other site 246197006844 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 246197006845 Response regulator receiver domain; Region: Response_reg; pfam00072 246197006846 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197006847 active site 246197006848 phosphorylation site [posttranslational modification] 246197006849 intermolecular recognition site; other site 246197006850 dimerization interface [polypeptide binding]; other site 246197006851 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197006852 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197006853 dimer interface [polypeptide binding]; other site 246197006854 phosphorylation site [posttranslational modification] 246197006855 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 246197006856 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 246197006857 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 246197006858 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 246197006859 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 246197006860 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 246197006861 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 246197006862 Zn binding site [ion binding]; other site 246197006863 BPG-independent PGAM N-terminus (iPGM_N); Region: iPGM_N; cl17463 246197006864 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 246197006865 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 246197006866 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 246197006867 G1 box; other site 246197006868 GTP/Mg2+ binding site [chemical binding]; other site 246197006869 G2 box; other site 246197006870 Switch I region; other site 246197006871 G3 box; other site 246197006872 Switch II region; other site 246197006873 G4 box; other site 246197006874 G5 box; other site 246197006875 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 246197006876 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 246197006877 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246197006878 motif II; other site 246197006879 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 246197006880 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246197006881 substrate binding site [chemical binding]; other site 246197006882 oxyanion hole (OAH) forming residues; other site 246197006883 trimer interface [polypeptide binding]; other site 246197006884 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 246197006885 Uncharacterized conserved protein [Function unknown]; Region: COG1683 246197006886 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 246197006887 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 246197006888 active site 246197006889 substrate binding site [chemical binding]; other site 246197006890 cosubstrate binding site; other site 246197006891 catalytic site [active] 246197006892 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 246197006893 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 246197006894 dimerization interface [polypeptide binding]; other site 246197006895 putative ATP binding site [chemical binding]; other site 246197006896 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 246197006897 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 246197006898 ligand binding site [chemical binding]; other site 246197006899 flexible hinge region; other site 246197006900 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 246197006901 cAMP phosphodiesterases class-II; Region: PDEase_II; cl17776 246197006902 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 246197006903 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 246197006904 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 246197006905 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 246197006906 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 246197006907 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246197006908 AMIN domain; Region: AMIN; pfam11741 246197006909 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 246197006910 OstA-like protein; Region: OstA; cl00844 246197006911 Organic solvent tolerance protein; Region: OstA_C; pfam04453 246197006912 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 246197006913 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246197006914 non-specific DNA binding site [nucleotide binding]; other site 246197006915 salt bridge; other site 246197006916 sequence-specific DNA binding site [nucleotide binding]; other site 246197006917 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 246197006918 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 246197006919 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246197006920 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246197006921 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 246197006922 enoyl-CoA hydratase; Validated; Region: PRK08139 246197006923 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246197006924 substrate binding site [chemical binding]; other site 246197006925 oxyanion hole (OAH) forming residues; other site 246197006926 trimer interface [polypeptide binding]; other site 246197006927 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 246197006928 Peptidase family M23; Region: Peptidase_M23; pfam01551 246197006929 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 246197006930 putative catalytic site [active] 246197006931 putative metal binding site [ion binding]; other site 246197006932 putative phosphate binding site [ion binding]; other site 246197006933 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 246197006934 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 246197006935 CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080 246197006936 CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080 246197006937 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 246197006938 cyclase homology domain; Region: CHD; cd07302 246197006939 nucleotidyl binding site; other site 246197006940 metal binding site [ion binding]; metal-binding site 246197006941 dimer interface [polypeptide binding]; other site 246197006942 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 246197006943 [2Fe-2S] cluster binding site [ion binding]; other site 246197006944 dimer interface [polypeptide binding]; other site 246197006945 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 246197006946 4Fe-4S binding domain; Region: Fer4; pfam00037 246197006947 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 246197006948 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 246197006949 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246197006950 catalytic loop [active] 246197006951 iron binding site [ion binding]; other site 246197006952 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 246197006953 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 246197006954 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 246197006955 NADH dehydrogenase subunit D; Validated; Region: PRK06075 246197006956 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 246197006957 Sulfatase; Region: Sulfatase; cl17466 246197006958 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 246197006959 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 246197006960 CoenzymeA binding site [chemical binding]; other site 246197006961 subunit interaction site [polypeptide binding]; other site 246197006962 PHB binding site; other site 246197006963 NADH dehydrogenase subunit B; Provisional; Region: PRK14817 246197006964 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 246197006965 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246197006966 dimerization interface [polypeptide binding]; other site 246197006967 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 246197006968 dimer interface [polypeptide binding]; other site 246197006969 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 246197006970 putative CheW interface [polypeptide binding]; other site 246197006971 amphi-Trp domain; Region: amphi-Trp; TIGR04354 246197006972 RNA polymerase sigma-70 factor, Myxococcales family 1; Region: Sig-70_gmx1; TIGR03001 246197006973 Putative zinc-finger; Region: zf-HC2; pfam13490 246197006974 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197006975 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197006976 active site 246197006977 ATP binding site [chemical binding]; other site 246197006978 substrate binding site [chemical binding]; other site 246197006979 activation loop (A-loop); other site 246197006980 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246197006981 Tetratricopeptide repeat; Region: TPR_12; pfam13424 246197006982 Tetratricopeptide repeat; Region: TPR_12; pfam13424 246197006983 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197006984 binding surface 246197006985 TPR motif; other site 246197006986 Tetratricopeptide repeat; Region: TPR_12; pfam13424 246197006987 Tetratricopeptide repeat; Region: TPR_12; pfam13424 246197006988 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 246197006989 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 246197006990 active site 246197006991 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 246197006992 OsmC-like protein; Region: OsmC; pfam02566 246197006993 arginine decarboxylase; Provisional; Region: PRK05354 246197006994 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 246197006995 active site 246197006996 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 246197006997 catalytic residues [active] 246197006998 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 246197006999 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 246197007000 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197007001 Walker A motif; other site 246197007002 ATP binding site [chemical binding]; other site 246197007003 Walker B motif; other site 246197007004 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 246197007005 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 246197007006 Colicin V production protein; Region: Colicin_V; pfam02674 246197007007 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 246197007008 HSP70 interaction site [polypeptide binding]; other site 246197007009 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 246197007010 nucleotide binding site [chemical binding]; other site 246197007011 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 246197007012 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 246197007013 active site 246197007014 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 246197007015 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 246197007016 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 246197007017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197007018 ATP binding site [chemical binding]; other site 246197007019 Mg2+ binding site [ion binding]; other site 246197007020 G-X-G motif; other site 246197007021 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 246197007022 Uncharacterized conserved protein [Function unknown]; Region: COG5470 246197007023 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 246197007024 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 246197007025 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 246197007026 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 246197007027 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 246197007028 active site 246197007029 Zn binding site [ion binding]; other site 246197007030 CAAX protease self-immunity; Region: Abi; pfam02517 246197007031 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 246197007032 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 246197007033 active site 246197007034 primer binding site [nucleotide binding]; other site 246197007035 NTP binding site [chemical binding]; other site 246197007036 metal binding triad [ion binding]; metal-binding site 246197007037 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 246197007038 Histidinol phosphatase and related hydrolases of the PHP family [Amino acid transport and metabolism / General function prediction only]; Region: HIS2; COG1387 246197007039 active site 246197007040 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 246197007041 iron-sulfur cluster [ion binding]; other site 246197007042 [2Fe-2S] cluster binding site [ion binding]; other site 246197007043 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 246197007044 MPT binding site; other site 246197007045 trimer interface [polypeptide binding]; other site 246197007046 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase; Region: M28_AAP; cd03879 246197007047 Peptidase family M28; Region: Peptidase_M28; pfam04389 246197007048 active site 246197007049 metal binding site [ion binding]; metal-binding site 246197007050 Yqey-like protein; Region: YqeY; cl17540 246197007051 Protein of unknown function (DUF2400); Region: DUF2400; pfam09674 246197007052 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197007053 dimer interface [polypeptide binding]; other site 246197007054 phosphorylation site [posttranslational modification] 246197007055 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197007056 ATP binding site [chemical binding]; other site 246197007057 G-X-G motif; other site 246197007058 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197007059 active site 246197007060 phosphorylation site [posttranslational modification] 246197007061 intermolecular recognition site; other site 246197007062 dimerization interface [polypeptide binding]; other site 246197007063 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 246197007064 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 246197007065 Gas vesicle protein; Region: Gas_vesicle; pfam00741 246197007066 Gas vesicle protein K; Region: GvpK; pfam05121 246197007067 Gas vesicle protein; Region: Gas_vesicle; pfam00741 246197007068 Gas vesicle protein G; Region: GvpG; pfam05120 246197007069 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 246197007070 gas vesicle synthesis protein GvpA; Provisional; Region: PRK09371 246197007071 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 246197007072 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 246197007073 AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243 246197007074 Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359 246197007075 Cell division protein 48 (CDC48), domain 2; Region: CDC48_2; pfam02933 246197007076 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197007077 Walker A motif; other site 246197007078 ATP binding site [chemical binding]; other site 246197007079 Walker B motif; other site 246197007080 arginine finger; other site 246197007081 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197007082 Walker A motif; other site 246197007083 ATP binding site [chemical binding]; other site 246197007084 Walker B motif; other site 246197007085 arginine finger; other site 246197007086 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 246197007087 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 246197007088 putative dimer interface [polypeptide binding]; other site 246197007089 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 246197007090 protein binding site [polypeptide binding]; other site 246197007091 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197007092 binding surface 246197007093 TPR repeat; Region: TPR_11; pfam13414 246197007094 TPR motif; other site 246197007095 TPR repeat; Region: TPR_11; pfam13414 246197007096 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 246197007097 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 246197007098 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197007099 active site 246197007100 phosphorylation site [posttranslational modification] 246197007101 intermolecular recognition site; other site 246197007102 dimerization interface [polypeptide binding]; other site 246197007103 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 246197007104 DNA binding site [nucleotide binding] 246197007105 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197007106 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197007107 dimer interface [polypeptide binding]; other site 246197007108 phosphorylation site [posttranslational modification] 246197007109 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197007110 ATP binding site [chemical binding]; other site 246197007111 Mg2+ binding site [ion binding]; other site 246197007112 G-X-G motif; other site 246197007113 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 246197007114 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246197007115 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 246197007116 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 246197007117 FtsX-like permease family; Region: FtsX; pfam02687 246197007118 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 246197007119 FtsX-like permease family; Region: FtsX; pfam02687 246197007120 PAS fold; Region: PAS_4; pfam08448 246197007121 GAF domain; Region: GAF_3; pfam13492 246197007122 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246197007123 PAS fold; Region: PAS_3; pfam08447 246197007124 putative active site [active] 246197007125 heme pocket [chemical binding]; other site 246197007126 PAS fold; Region: PAS; pfam00989 246197007127 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246197007128 putative active site [active] 246197007129 heme pocket [chemical binding]; other site 246197007130 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197007131 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197007132 dimer interface [polypeptide binding]; other site 246197007133 phosphorylation site [posttranslational modification] 246197007134 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197007135 ATP binding site [chemical binding]; other site 246197007136 Mg2+ binding site [ion binding]; other site 246197007137 G-X-G motif; other site 246197007138 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 246197007139 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197007140 active site 246197007141 phosphorylation site [posttranslational modification] 246197007142 intermolecular recognition site; other site 246197007143 dimerization interface [polypeptide binding]; other site 246197007144 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 246197007145 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 246197007146 dimer interface [polypeptide binding]; other site 246197007147 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 246197007148 active site 246197007149 Fe binding site [ion binding]; other site 246197007150 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 246197007151 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 246197007152 iron-sulfur cluster [ion binding]; other site 246197007153 [2Fe-2S] cluster binding site [ion binding]; other site 246197007154 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 246197007155 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 246197007156 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 246197007157 Dual-action HEIGH metallo-peptidase; Region: Peptidase_M57; pfam12388 246197007158 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246197007159 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246197007160 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 246197007161 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246197007162 Walker A/P-loop; other site 246197007163 ATP binding site [chemical binding]; other site 246197007164 Q-loop/lid; other site 246197007165 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 246197007166 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246197007167 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 246197007168 Walker A/P-loop; other site 246197007169 ATP binding site [chemical binding]; other site 246197007170 Q-loop/lid; other site 246197007171 ABC transporter signature motif; other site 246197007172 Walker B; other site 246197007173 D-loop; other site 246197007174 H-loop/switch region; other site 246197007175 N-terminal formyl transferase catalytic core domain of NRPS_like proteins, one of the proteins involved in the synthesis of Oxazolomycin; Region: FMT_core_NRPS_like; cd08649 246197007176 putative active site [active] 246197007177 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 246197007178 putative substrate binding site [chemical binding]; other site 246197007179 putative cosubstrate binding site; other site 246197007180 catalytic site [active] 246197007181 C-terminal subdomain of the Formyltransferase-like domain found in OzmH-like proteins; Region: FMT_C_OzmH_like; cd08700 246197007182 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197007183 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246197007184 acyl-activating enzyme (AAE) consensus motif; other site 246197007185 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 246197007186 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 246197007187 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246197007188 AMP binding site [chemical binding]; other site 246197007189 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197007190 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246197007191 TAP-like protein; Region: Abhydrolase_4; pfam08386 246197007192 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246197007193 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 246197007194 active site 246197007195 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 246197007196 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 246197007197 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 246197007198 putative NADP binding site [chemical binding]; other site 246197007199 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 246197007200 active site 246197007201 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 246197007202 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197007203 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 246197007204 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 246197007205 Mechanosensitive ion channel; Region: MS_channel; pfam00924 246197007206 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 246197007207 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 246197007208 ligand binding site [chemical binding]; other site 246197007209 flexible hinge region; other site 246197007210 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 246197007211 DNA polymerase III subunit delta'; Validated; Region: PRK08485 246197007212 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 246197007213 DNA polymerase III, delta subunit; Region: holA; TIGR01128 246197007214 NRDE protein; Region: NRDE; cl01315 246197007215 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 246197007216 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 246197007217 active site 246197007218 HIGH motif; other site 246197007219 KMSKS motif; other site 246197007220 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 246197007221 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 246197007222 dimer interface [polypeptide binding]; other site 246197007223 putative tRNA-binding site [nucleotide binding]; other site 246197007224 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 246197007225 protein binding surface [polypeptide binding]; other site 246197007226 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 246197007227 active site 246197007228 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 246197007229 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 246197007230 Zn2+ binding site [ion binding]; other site 246197007231 Mg2+ binding site [ion binding]; other site 246197007232 Response regulator receiver domain; Region: Response_reg; pfam00072 246197007233 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197007234 active site 246197007235 phosphorylation site [posttranslational modification] 246197007236 intermolecular recognition site; other site 246197007237 dimerization interface [polypeptide binding]; other site 246197007238 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 246197007239 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 246197007240 generic binding surface II; other site 246197007241 generic binding surface I; other site 246197007242 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 246197007243 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 246197007244 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 246197007245 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 246197007246 putative RNA binding site [nucleotide binding]; other site 246197007247 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197007248 S-adenosylmethionine binding site [chemical binding]; other site 246197007249 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 246197007250 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 246197007251 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 246197007252 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 246197007253 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 246197007254 active site 246197007255 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 246197007256 Interdomain contacts; other site 246197007257 Cytokine receptor motif; other site 246197007258 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 246197007259 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 246197007260 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 246197007261 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 246197007262 Phosphoglycerate kinase; Region: PGK; pfam00162 246197007263 substrate binding site [chemical binding]; other site 246197007264 hinge regions; other site 246197007265 ADP binding site [chemical binding]; other site 246197007266 catalytic site [active] 246197007267 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 246197007268 triosephosphate isomerase; Provisional; Region: PRK14565 246197007269 substrate binding site [chemical binding]; other site 246197007270 dimer interface [polypeptide binding]; other site 246197007271 catalytic triad [active] 246197007272 protein translocase, SecG subunit; Region: secG; TIGR00810 246197007273 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 246197007274 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 246197007275 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 246197007276 NMT1/THI5 like; Region: NMT1; pfam09084 246197007277 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 246197007278 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246197007279 dimer interface [polypeptide binding]; other site 246197007280 conserved gate region; other site 246197007281 putative PBP binding loops; other site 246197007282 ABC-ATPase subunit interface; other site 246197007283 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 246197007284 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 246197007285 Walker A/P-loop; other site 246197007286 ATP binding site [chemical binding]; other site 246197007287 Q-loop/lid; other site 246197007288 ABC transporter signature motif; other site 246197007289 Walker B; other site 246197007290 D-loop; other site 246197007291 H-loop/switch region; other site 246197007292 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 246197007293 active site 246197007294 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246197007295 dimerization interface [polypeptide binding]; other site 246197007296 putative DNA binding site [nucleotide binding]; other site 246197007297 putative Zn2+ binding site [ion binding]; other site 246197007298 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 246197007299 putative hydrophobic ligand binding site [chemical binding]; other site 246197007300 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 246197007301 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197007302 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197007303 active site 246197007304 ATP binding site [chemical binding]; other site 246197007305 substrate binding site [chemical binding]; other site 246197007306 activation loop (A-loop); other site 246197007307 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 246197007308 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 246197007309 NAD(P) binding site [chemical binding]; other site 246197007310 catalytic residues [active] 246197007311 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 246197007312 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246197007313 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 246197007314 dimerization interface [polypeptide binding]; other site 246197007315 acetolactate synthase; Reviewed; Region: PRK08322 246197007316 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 246197007317 PYR/PP interface [polypeptide binding]; other site 246197007318 dimer interface [polypeptide binding]; other site 246197007319 TPP binding site [chemical binding]; other site 246197007320 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 246197007321 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 246197007322 TPP-binding site [chemical binding]; other site 246197007323 dimer interface [polypeptide binding]; other site 246197007324 Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147 246197007325 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 246197007326 NAD(P) binding site [chemical binding]; other site 246197007327 catalytic residues [active] 246197007328 hypothetical protein; Provisional; Region: PRK11568 246197007329 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 246197007330 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 246197007331 recombination factor protein RarA; Reviewed; Region: PRK13342 246197007332 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197007333 Walker A motif; other site 246197007334 ATP binding site [chemical binding]; other site 246197007335 Walker B motif; other site 246197007336 arginine finger; other site 246197007337 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 246197007338 TIGR03118 family protein; Region: PEPCTERM_chp_1 246197007339 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 246197007340 Nudix hydrolase homolog; Region: PLN02791 246197007341 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 246197007342 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 246197007343 Amidase; Region: Amidase; cl11426 246197007344 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 246197007345 Peptidase C39 family; Region: Peptidase_C39; pfam03412 246197007346 putative active site [active] 246197007347 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 246197007348 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246197007349 Walker A/P-loop; other site 246197007350 ATP binding site [chemical binding]; other site 246197007351 Q-loop/lid; other site 246197007352 ABC transporter signature motif; other site 246197007353 Walker B; other site 246197007354 D-loop; other site 246197007355 H-loop/switch region; other site 246197007356 type 2 lantibiotic, mersacidin/lichenicidin family; Region: lanti_MRSA_kill; TIGR03898 246197007357 type 2 lantibiotic, mersacidin/lichenicidin family; Region: lanti_MRSA_kill; TIGR03898 246197007358 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 246197007359 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 246197007360 active site 246197007361 zinc binding site [ion binding]; other site 246197007362 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 246197007363 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246197007364 ATP binding site [chemical binding]; other site 246197007365 putative Mg++ binding site [ion binding]; other site 246197007366 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246197007367 nucleotide binding region [chemical binding]; other site 246197007368 ATP-binding site [chemical binding]; other site 246197007369 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 246197007370 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 246197007371 homodimer interface [polypeptide binding]; other site 246197007372 homotetramer interface [polypeptide binding]; other site 246197007373 active site pocket [active] 246197007374 cleavage site 246197007375 HEAT repeats; Region: HEAT_2; pfam13646 246197007376 Phosphate-selective porin [Inorganic ion transport and metabolism]; Region: OprP; COG3746 246197007377 Surface antigen; Region: Bac_surface_Ag; pfam01103 246197007378 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 246197007379 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 246197007380 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246197007381 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 246197007382 putative catalytic site [active] 246197007383 putative metal binding site [ion binding]; other site 246197007384 putative phosphate binding site [ion binding]; other site 246197007385 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 246197007386 Lamin Tail Domain; Region: LTD; pfam00932 246197007387 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246197007388 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246197007389 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 246197007390 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 246197007391 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 246197007392 Uncharacterized conserved protein [Function unknown]; Region: COG3391 246197007393 SdiA-regulated; Region: SdiA-regulated; cd09971 246197007394 putative active site [active] 246197007395 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 246197007396 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 246197007397 Zn binding site [ion binding]; other site 246197007398 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 246197007399 Ferritin-like domain; Region: Ferritin; pfam00210 246197007400 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 246197007401 dinuclear metal binding motif [ion binding]; other site 246197007402 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 246197007403 uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_2; cd07805 246197007404 N- and C-terminal domain interface [polypeptide binding]; other site 246197007405 active site 246197007406 MgATP binding site [chemical binding]; other site 246197007407 catalytic site [active] 246197007408 metal binding site [ion binding]; metal-binding site 246197007409 xylulose binding site [chemical binding]; other site 246197007410 putative homodimer interface [polypeptide binding]; other site 246197007411 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 246197007412 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 246197007413 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246197007414 catalytic residue [active] 246197007415 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 246197007416 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183 246197007417 putative active site [active] 246197007418 metal binding site [ion binding]; metal-binding site 246197007419 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 246197007420 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 246197007421 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 246197007422 AAA ATPase domain; Region: AAA_16; pfam13191 246197007423 Tetratricopeptide repeat; Region: TPR_12; pfam13424 246197007424 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197007425 binding surface 246197007426 TPR repeat; Region: TPR_11; pfam13414 246197007427 TPR motif; other site 246197007428 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 246197007429 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 246197007430 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 246197007431 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246197007432 motif II; other site 246197007433 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 246197007434 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 246197007435 coproporphyrinogen III oxidase; Validated; Region: PRK08208 246197007436 HemN C-terminal domain; Region: HemN_C; pfam06969 246197007437 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246197007438 Radical SAM superfamily; Region: Radical_SAM; pfam04055 246197007439 FeS/SAM binding site; other site 246197007440 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 246197007441 repeat-companion domain TIGR02996; Region: rpt_mate_G_obs 246197007442 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 246197007443 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 246197007444 repeat-companion domain TIGR02996; Region: rpt_mate_G_obs 246197007445 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 246197007446 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 246197007447 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 246197007448 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197007449 Walker A motif; other site 246197007450 ATP binding site [chemical binding]; other site 246197007451 Walker B motif; other site 246197007452 arginine finger; other site 246197007453 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197007454 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 246197007455 Walker A motif; other site 246197007456 ATP binding site [chemical binding]; other site 246197007457 Walker B motif; other site 246197007458 arginine finger; other site 246197007459 Peptidase family M41; Region: Peptidase_M41; pfam01434 246197007460 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 246197007461 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246197007462 FeS/SAM binding site; other site 246197007463 PilZ domain; Region: PilZ; pfam07238 246197007464 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 246197007465 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197007466 Walker A motif; other site 246197007467 ATP binding site [chemical binding]; other site 246197007468 Walker B motif; other site 246197007469 arginine finger; other site 246197007470 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 246197007471 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 246197007472 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 246197007473 ATP binding site [chemical binding]; other site 246197007474 substrate interface [chemical binding]; other site 246197007475 Penicillin amidase; Region: Penicil_amidase; pfam01804 246197007476 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 246197007477 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 246197007478 active site 246197007479 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 246197007480 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 246197007481 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 246197007482 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197007483 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197007484 active site 246197007485 ATP binding site [chemical binding]; other site 246197007486 substrate binding site [chemical binding]; other site 246197007487 activation loop (A-loop); other site 246197007488 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197007489 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197007490 active site 246197007491 ATP binding site [chemical binding]; other site 246197007492 substrate binding site [chemical binding]; other site 246197007493 activation loop (A-loop); other site 246197007494 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 246197007495 DNA binding residues [nucleotide binding] 246197007496 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246197007497 DNA binding residues [nucleotide binding] 246197007498 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 246197007499 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 246197007500 purine monophosphate binding site [chemical binding]; other site 246197007501 dimer interface [polypeptide binding]; other site 246197007502 putative catalytic residues [active] 246197007503 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 246197007504 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 246197007505 zinc-ribbon domain; Region: zinc_ribbon_4; pfam13717 246197007506 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197007507 TPR motif; other site 246197007508 binding surface 246197007509 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 246197007510 binding surface 246197007511 TPR motif; other site 246197007512 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 246197007513 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 246197007514 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 246197007515 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 246197007516 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 246197007517 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 246197007518 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 246197007519 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 246197007520 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 246197007521 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246197007522 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246197007523 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 246197007524 putative ADP-binding pocket [chemical binding]; other site 246197007525 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 246197007526 CoA binding domain; Region: CoA_binding; smart00881 246197007527 Bacterial sugar transferase; Region: Bac_transf; pfam02397 246197007528 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 246197007529 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 246197007530 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 246197007531 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 246197007532 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 246197007533 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 246197007534 active site 246197007535 dimer interface [polypeptide binding]; other site 246197007536 effector binding site; other site 246197007537 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 246197007538 TSCPD domain; Region: TSCPD; pfam12637 246197007539 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 246197007540 dimer interface [polypeptide binding]; other site 246197007541 [2Fe-2S] cluster binding site [ion binding]; other site 246197007542 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 246197007543 Glyco_18 domain; Region: Glyco_18; smart00636 246197007544 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 246197007545 active site 246197007546 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 246197007547 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246197007548 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246197007549 DNA binding residues [nucleotide binding] 246197007550 TPR repeat; Region: TPR_11; pfam13414 246197007551 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197007552 binding surface 246197007553 TPR motif; other site 246197007554 beta propeller repeat, Methanosarcina surface protein type; Region: beta_prop_Msarc; TIGR04275 246197007555 beta propeller repeat, Methanosarcina surface protein type; Region: beta_prop_Msarc; TIGR04275 246197007556 beta propeller repeat, Methanosarcina surface protein type; Region: beta_prop_Msarc; TIGR04275 246197007557 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3397 246197007558 Chitin binding domain; Region: Chitin_bind_3; pfam03067 246197007559 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 246197007560 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 246197007561 Isochorismatase family; Region: Isochorismatase; pfam00857 246197007562 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 246197007563 catalytic triad [active] 246197007564 dimer interface [polypeptide binding]; other site 246197007565 conserved cis-peptide bond; other site 246197007566 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 246197007567 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 246197007568 putative PBP binding regions; other site 246197007569 ABC-ATPase subunit interface; other site 246197007570 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 246197007571 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246197007572 Walker A/P-loop; other site 246197007573 ATP binding site [chemical binding]; other site 246197007574 Q-loop/lid; other site 246197007575 ABC transporter signature motif; other site 246197007576 Walker B; other site 246197007577 D-loop; other site 246197007578 H-loop/switch region; other site 246197007579 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 246197007580 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 246197007581 intersubunit interface [polypeptide binding]; other site 246197007582 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 246197007583 iron-sulfur cluster [ion binding]; other site 246197007584 [2Fe-2S] cluster binding site [ion binding]; other site 246197007585 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 246197007586 GTP cyclohydrolase I; Provisional; Region: PLN03044 246197007587 active site 246197007588 FAD binding domain; Region: FAD_binding_4; pfam01565 246197007589 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 246197007590 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 246197007591 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246197007592 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 246197007593 acyl-activating enzyme (AAE) consensus motif; other site 246197007594 putative AMP binding site [chemical binding]; other site 246197007595 putative active site [active] 246197007596 putative CoA binding site [chemical binding]; other site 246197007597 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 246197007598 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197007599 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197007600 dimer interface [polypeptide binding]; other site 246197007601 phosphorylation site [posttranslational modification] 246197007602 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197007603 ATP binding site [chemical binding]; other site 246197007604 G-X-G motif; other site 246197007605 Response regulator receiver domain; Region: Response_reg; pfam00072 246197007606 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197007607 active site 246197007608 phosphorylation site [posttranslational modification] 246197007609 intermolecular recognition site; other site 246197007610 dimerization interface [polypeptide binding]; other site 246197007611 SCP-2 sterol transfer family; Region: SCP2; pfam02036 246197007612 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 246197007613 CoA-transferase family III; Region: CoA_transf_3; pfam02515 246197007614 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 246197007615 MarR family; Region: MarR; pfam01047 246197007616 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 246197007617 Protein export membrane protein; Region: SecD_SecF; cl14618 246197007618 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 246197007619 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 246197007620 HlyD family secretion protein; Region: HlyD_3; pfam13437 246197007621 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246197007622 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246197007623 active site 246197007624 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 246197007625 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 246197007626 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 246197007627 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197007628 S-adenosylmethionine binding site [chemical binding]; other site 246197007629 MG2 domain; Region: A2M_N; pfam01835 246197007630 Alpha-2-macroglobulin family N-terminal region; Region: A2M_N_2; pfam07703 246197007631 Alpha-2-macroglobulin family; Region: A2M; pfam00207 246197007632 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 246197007633 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 246197007634 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 246197007635 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 246197007636 active site 246197007637 HIGH motif; other site 246197007638 dimer interface [polypeptide binding]; other site 246197007639 KMSKS motif; other site 246197007640 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 246197007641 RNA binding surface [nucleotide binding]; other site 246197007642 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 246197007643 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 246197007644 putative active site [active] 246197007645 metal binding site [ion binding]; metal-binding site 246197007646 homodimer binding site [polypeptide binding]; other site 246197007647 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 246197007648 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 246197007649 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197007650 binding surface 246197007651 TPR motif; other site 246197007652 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246197007653 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197007654 active site 246197007655 ATP binding site [chemical binding]; other site 246197007656 substrate binding site [chemical binding]; other site 246197007657 activation loop (A-loop); other site 246197007658 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 246197007659 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 246197007660 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246197007661 catalytic residue [active] 246197007662 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 246197007663 DHH family; Region: DHH; pfam01368 246197007664 Fic family protein [Function unknown]; Region: COG3177 246197007665 Fic/DOC family; Region: Fic; pfam02661 246197007666 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 246197007667 Walker A motif; other site 246197007668 ATP binding site [chemical binding]; other site 246197007669 Walker B motif; other site 246197007670 arginine finger; other site 246197007671 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 246197007672 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 246197007673 homodimer interface [polypeptide binding]; other site 246197007674 substrate-cofactor binding pocket; other site 246197007675 catalytic residue [active] 246197007676 Patatin-like phospholipase; Region: Patatin; pfam01734 246197007677 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197007678 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 246197007679 Walker A motif; other site 246197007680 ATP binding site [chemical binding]; other site 246197007681 Walker B motif; other site 246197007682 arginine finger; other site 246197007683 Response regulator receiver domain; Region: Response_reg; pfam00072 246197007684 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197007685 active site 246197007686 phosphorylation site [posttranslational modification] 246197007687 intermolecular recognition site; other site 246197007688 dimerization interface [polypeptide binding]; other site 246197007689 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 246197007690 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246197007691 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 246197007692 Uncharacterized conserved protein [Function unknown]; Region: COG1543 246197007693 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 246197007694 active site 246197007695 substrate binding site [chemical binding]; other site 246197007696 catalytic site [active] 246197007697 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 246197007698 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 246197007699 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 246197007700 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 246197007701 protein binding site [polypeptide binding]; other site 246197007702 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 246197007703 protein binding site [polypeptide binding]; other site 246197007704 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 246197007705 active site 246197007706 catalytic triad [active] 246197007707 oxyanion hole [active] 246197007708 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246197007709 dimerization interface [polypeptide binding]; other site 246197007710 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 246197007711 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 246197007712 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 246197007713 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 246197007714 metal binding site [ion binding]; metal-binding site 246197007715 active site 246197007716 I-site; other site 246197007717 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 246197007718 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 246197007719 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 246197007720 Tetratricopeptide repeat; Region: TPR_6; pfam13174 246197007721 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 246197007722 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 246197007723 DNA protecting protein DprA; Region: dprA; TIGR00732 246197007724 DNA topoisomerase I; Validated; Region: PRK06599 246197007725 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 246197007726 active site 246197007727 interdomain interaction site; other site 246197007728 putative metal-binding site [ion binding]; other site 246197007729 nucleotide binding site [chemical binding]; other site 246197007730 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 246197007731 domain I; other site 246197007732 DNA binding groove [nucleotide binding] 246197007733 phosphate binding site [ion binding]; other site 246197007734 domain II; other site 246197007735 domain III; other site 246197007736 nucleotide binding site [chemical binding]; other site 246197007737 catalytic site [active] 246197007738 domain IV; other site 246197007739 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 246197007740 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 246197007741 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 246197007742 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 246197007743 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 246197007744 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 246197007745 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 246197007746 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 246197007747 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 246197007748 Glucose inhibited division protein A; Region: GIDA; pfam01134 246197007749 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 246197007750 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 246197007751 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 246197007752 active site 246197007753 DNA binding site [nucleotide binding] 246197007754 Int/Topo IB signature motif; other site 246197007755 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 246197007756 transmembrane helices; other site 246197007757 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 246197007758 TrkA-C domain; Region: TrkA_C; pfam02080 246197007759 TrkA-C domain; Region: TrkA_C; pfam02080 246197007760 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 246197007761 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 246197007762 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 246197007763 active site 246197007764 HslU subunit interaction site [polypeptide binding]; other site 246197007765 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 246197007766 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197007767 Walker A motif; other site 246197007768 ATP binding site [chemical binding]; other site 246197007769 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 246197007770 Walker B motif; other site 246197007771 arginine finger; other site 246197007772 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 246197007773 acetylornithine aminotransferase; Provisional; Region: PRK02627 246197007774 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 246197007775 inhibitor-cofactor binding pocket; inhibition site 246197007776 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246197007777 catalytic residue [active] 246197007778 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 246197007779 HSP70 interaction site [polypeptide binding]; other site 246197007780 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 246197007781 TPR motif; other site 246197007782 binding surface 246197007783 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 246197007784 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 246197007785 nucleotide binding site [chemical binding]; other site 246197007786 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 246197007787 active site 246197007788 catalytic site [active] 246197007789 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 246197007790 active site 2 [active] 246197007791 active site 1 [active] 246197007792 thioester reductase domain; Region: Thioester-redct; TIGR01746 246197007793 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 246197007794 putative NAD(P) binding site [chemical binding]; other site 246197007795 active site 246197007796 putative substrate binding site [chemical binding]; other site 246197007797 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 246197007798 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 246197007799 CoA-binding site [chemical binding]; other site 246197007800 ATP-binding [chemical binding]; other site 246197007801 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 246197007802 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 246197007803 G1 box; other site 246197007804 GTP/Mg2+ binding site [chemical binding]; other site 246197007805 Switch I region; other site 246197007806 G2 box; other site 246197007807 G3 box; other site 246197007808 Switch II region; other site 246197007809 G4 box; other site 246197007810 G5 box; other site 246197007811 O-Antigen ligase; Region: Wzy_C; cl04850 246197007812 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246197007813 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 246197007814 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 246197007815 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 246197007816 quinone interaction residues [chemical binding]; other site 246197007817 active site 246197007818 catalytic residues [active] 246197007819 FMN binding site [chemical binding]; other site 246197007820 substrate binding site [chemical binding]; other site 246197007821 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246197007822 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 246197007823 active site 246197007824 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 246197007825 Smr domain; Region: Smr; pfam01713 246197007826 tellurium resistance terB-like protein; Region: terB_like; cd07177 246197007827 metal binding site [ion binding]; metal-binding site 246197007828 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 246197007829 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 246197007830 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 246197007831 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 246197007832 homodimer interface [polypeptide binding]; other site 246197007833 NADP binding site [chemical binding]; other site 246197007834 substrate binding site [chemical binding]; other site 246197007835 Methyltransferase domain; Region: Methyltransf_23; pfam13489 246197007836 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197007837 S-adenosylmethionine binding site [chemical binding]; other site 246197007838 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 246197007839 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197007840 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197007841 dimer interface [polypeptide binding]; other site 246197007842 phosphorylation site [posttranslational modification] 246197007843 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197007844 ATP binding site [chemical binding]; other site 246197007845 Mg2+ binding site [ion binding]; other site 246197007846 G-X-G motif; other site 246197007847 Myxococcales-restricted protein, TIGR02265 family; Region: Mxa_TIGR02265 246197007848 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 246197007849 FAD binding site [chemical binding]; other site 246197007850 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 246197007851 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 246197007852 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 246197007853 lipoyl attachment site [posttranslational modification]; other site 246197007854 glycine dehydrogenase; Provisional; Region: PRK05367 246197007855 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 246197007856 tetramer interface [polypeptide binding]; other site 246197007857 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246197007858 catalytic residue [active] 246197007859 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 246197007860 tetramer interface [polypeptide binding]; other site 246197007861 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246197007862 catalytic residue [active] 246197007863 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 246197007864 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 246197007865 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 246197007866 Stage II sporulation protein; Region: SpoIID; pfam08486 246197007867 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 246197007868 Right handed beta helix region; Region: Beta_helix; pfam13229 246197007869 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246197007870 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246197007871 active site 246197007872 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 246197007873 active site residue [active] 246197007874 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 246197007875 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 246197007876 Ferredoxin [Energy production and conversion]; Region: COG1146 246197007877 4Fe-4S binding domain; Region: Fer4; pfam00037 246197007878 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 246197007879 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 246197007880 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246197007881 Coenzyme A binding pocket [chemical binding]; other site 246197007882 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 246197007883 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246197007884 ATP binding site [chemical binding]; other site 246197007885 putative Mg++ binding site [ion binding]; other site 246197007886 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246197007887 nucleotide binding region [chemical binding]; other site 246197007888 Helicase associated domain (HA2); Region: HA2; pfam04408 246197007889 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 246197007890 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 246197007891 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246197007892 motif II; other site 246197007893 HEAT repeats; Region: HEAT_2; pfam13646 246197007894 HEAT repeat; Region: HEAT; pfam02985 246197007895 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 246197007896 metal ion-dependent adhesion site (MIDAS); other site 246197007897 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 246197007898 ATP-grasp domain; Region: ATP-grasp_4; cl17255 246197007899 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 246197007900 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 246197007901 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 246197007902 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 246197007903 elongation factor Tu; Reviewed; Region: PRK00049 246197007904 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 246197007905 G1 box; other site 246197007906 GEF interaction site [polypeptide binding]; other site 246197007907 GTP/Mg2+ binding site [chemical binding]; other site 246197007908 Switch I region; other site 246197007909 G2 box; other site 246197007910 G3 box; other site 246197007911 Switch II region; other site 246197007912 G4 box; other site 246197007913 G5 box; other site 246197007914 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 246197007915 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 246197007916 Antibiotic Binding Site [chemical binding]; other site 246197007917 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 246197007918 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 246197007919 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 246197007920 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 246197007921 putative homodimer interface [polypeptide binding]; other site 246197007922 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 246197007923 heterodimer interface [polypeptide binding]; other site 246197007924 homodimer interface [polypeptide binding]; other site 246197007925 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 246197007926 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 246197007927 23S rRNA interface [nucleotide binding]; other site 246197007928 L7/L12 interface [polypeptide binding]; other site 246197007929 putative thiostrepton binding site; other site 246197007930 L25 interface [polypeptide binding]; other site 246197007931 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 246197007932 mRNA/rRNA interface [nucleotide binding]; other site 246197007933 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 246197007934 23S rRNA interface [nucleotide binding]; other site 246197007935 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 246197007936 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 246197007937 core dimer interface [polypeptide binding]; other site 246197007938 peripheral dimer interface [polypeptide binding]; other site 246197007939 L10 interface [polypeptide binding]; other site 246197007940 L11 interface [polypeptide binding]; other site 246197007941 putative EF-Tu interaction site [polypeptide binding]; other site 246197007942 putative EF-G interaction site [polypeptide binding]; other site 246197007943 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 246197007944 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 246197007945 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 246197007946 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 246197007947 RPB11 interaction site [polypeptide binding]; other site 246197007948 RPB12 interaction site [polypeptide binding]; other site 246197007949 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 246197007950 RPB3 interaction site [polypeptide binding]; other site 246197007951 RPB1 interaction site [polypeptide binding]; other site 246197007952 RPB11 interaction site [polypeptide binding]; other site 246197007953 RPB10 interaction site [polypeptide binding]; other site 246197007954 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 246197007955 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 246197007956 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 246197007957 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 246197007958 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 246197007959 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 246197007960 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 246197007961 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 246197007962 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 246197007963 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 246197007964 DNA binding site [nucleotide binding] 246197007965 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 246197007966 hypothetical protein; Provisional; Region: PRK11281 246197007967 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 246197007968 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 246197007969 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 246197007970 N-acetyl-D-glucosamine binding site [chemical binding]; other site 246197007971 catalytic residue [active] 246197007972 Tetratricopeptide repeat; Region: TPR_12; pfam13424 246197007973 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197007974 binding surface 246197007975 TPR motif; other site 246197007976 Tetratricopeptide repeat; Region: TPR_16; pfam13432 246197007977 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197007978 binding surface 246197007979 TPR motif; other site 246197007980 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246197007981 non-specific DNA binding site [nucleotide binding]; other site 246197007982 salt bridge; other site 246197007983 sequence-specific DNA binding site [nucleotide binding]; other site 246197007984 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 246197007985 Recombination protein O N terminal; Region: RecO_N; pfam11967 246197007986 Recombination protein O C terminal; Region: RecO_C; pfam02565 246197007987 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 246197007988 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 246197007989 putative substrate binding site [chemical binding]; other site 246197007990 putative ATP binding site [chemical binding]; other site 246197007991 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 246197007992 oligopeptide transporter, OPT superfamily; Region: OPT_sfam; TIGR00728 246197007993 OPT oligopeptide transporter protein; Region: OPT; pfam03169 246197007994 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197007995 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197007996 active site 246197007997 ATP binding site [chemical binding]; other site 246197007998 substrate binding site [chemical binding]; other site 246197007999 activation loop (A-loop); other site 246197008000 AAA ATPase domain; Region: AAA_16; pfam13191 246197008001 Tetratricopeptide repeat; Region: TPR_12; pfam13424 246197008002 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197008003 active site 246197008004 ATP binding site [chemical binding]; other site 246197008005 substrate binding site [chemical binding]; other site 246197008006 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197008007 activation loop (A-loop); other site 246197008008 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246197008009 phosphopeptide binding site; other site 246197008010 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 246197008011 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197008012 Walker A motif; other site 246197008013 ATP binding site [chemical binding]; other site 246197008014 Walker B motif; other site 246197008015 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 246197008016 Protein of unknown function (DUF419); Region: DUF419; pfam04237 246197008017 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 246197008018 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 246197008019 ligand binding site [chemical binding]; other site 246197008020 flexible hinge region; other site 246197008021 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 246197008022 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246197008023 putative active site [active] 246197008024 heme pocket [chemical binding]; other site 246197008025 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197008026 dimer interface [polypeptide binding]; other site 246197008027 phosphorylation site [posttranslational modification] 246197008028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197008029 ATP binding site [chemical binding]; other site 246197008030 Mg2+ binding site [ion binding]; other site 246197008031 G-X-G motif; other site 246197008032 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197008033 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197008034 active site 246197008035 ATP binding site [chemical binding]; other site 246197008036 substrate binding site [chemical binding]; other site 246197008037 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246197008038 substrate binding site [chemical binding]; other site 246197008039 activation loop (A-loop); other site 246197008040 activation loop (A-loop); other site 246197008041 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 246197008042 dimer interface [polypeptide binding]; other site 246197008043 motif 1; other site 246197008044 active site 246197008045 motif 2; other site 246197008046 motif 3; other site 246197008047 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 246197008048 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246197008049 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 246197008050 phosphopeptide binding site; other site 246197008051 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 246197008052 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 246197008053 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 246197008054 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 246197008055 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246197008056 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 246197008057 phosphopeptide binding site; other site 246197008058 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 246197008059 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 246197008060 ATP binding site [chemical binding]; other site 246197008061 Walker A motif; other site 246197008062 hexamer interface [polypeptide binding]; other site 246197008063 Walker B motif; other site 246197008064 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 246197008065 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246197008066 phosphopeptide binding site; other site 246197008067 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246197008068 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 246197008069 phosphopeptide binding site; other site 246197008070 DNA polymerase I; Provisional; Region: PRK05755 246197008071 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 246197008072 active site 246197008073 metal binding site 1 [ion binding]; metal-binding site 246197008074 putative 5' ssDNA interaction site; other site 246197008075 metal binding site 3; metal-binding site 246197008076 metal binding site 2 [ion binding]; metal-binding site 246197008077 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 246197008078 putative DNA binding site [nucleotide binding]; other site 246197008079 putative metal binding site [ion binding]; other site 246197008080 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 246197008081 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 246197008082 active site 246197008083 DNA binding site [nucleotide binding] 246197008084 catalytic site [active] 246197008085 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 246197008086 DivIVA protein; Region: DivIVA; pfam05103 246197008087 DivIVA domain; Region: DivI1A_domain; TIGR03544 246197008088 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 246197008089 HSP70 interaction site [polypeptide binding]; other site 246197008090 Integral membrane protein DUF95; Region: DUF95; pfam01944 246197008091 RDD family; Region: RDD; pfam06271 246197008092 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246197008093 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197008094 active site 246197008095 phosphorylation site [posttranslational modification] 246197008096 intermolecular recognition site; other site 246197008097 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246197008098 DNA binding residues [nucleotide binding] 246197008099 dimerization interface [polypeptide binding]; other site 246197008100 MbtH-like protein; Region: MbtH; cl01279 246197008101 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 246197008102 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 246197008103 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 246197008104 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 246197008105 TIR domain; Region: TIR_2; cl17458 246197008106 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820 246197008107 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 246197008108 dimer interface [polypeptide binding]; other site 246197008109 active site 246197008110 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 246197008111 substrate binding site [chemical binding]; other site 246197008112 catalytic residue [active] 246197008113 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 246197008114 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 246197008115 ArsC family; Region: ArsC; pfam03960 246197008116 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 246197008117 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 246197008118 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 246197008119 Putative exonuclease, RdgC; Region: RdgC; cl01122 246197008120 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 246197008121 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 246197008122 conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806 246197008123 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 246197008124 putative catalytic site [active] 246197008125 putative metal binding site [ion binding]; other site 246197008126 putative phosphate binding site [ion binding]; other site 246197008127 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 246197008128 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 246197008129 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246197008130 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246197008131 xanthine dehydrogenase; Region: PLN02906 246197008132 catalytic loop [active] 246197008133 iron binding site [ion binding]; other site 246197008134 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 246197008135 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 246197008136 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 246197008137 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 246197008138 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 246197008139 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 246197008140 XdhC Rossmann domain; Region: XdhC_C; pfam13478 246197008141 Protein of unknown function (DUF418); Region: DUF418; pfam04235 246197008142 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 246197008143 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 246197008144 minor groove reading motif; other site 246197008145 helix-hairpin-helix signature motif; other site 246197008146 substrate binding pocket [chemical binding]; other site 246197008147 active site 246197008148 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 246197008149 M6 family metalloprotease domain; Region: M6dom_TIGR03296 246197008150 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246197008151 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246197008152 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 246197008153 putative effector binding pocket; other site 246197008154 dimerization interface [polypeptide binding]; other site 246197008155 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 246197008156 homotrimer interaction site [polypeptide binding]; other site 246197008157 putative active site [active] 246197008158 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 246197008159 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 246197008160 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; pfam05985 246197008161 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 246197008162 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246197008163 substrate binding site [chemical binding]; other site 246197008164 oxyanion hole (OAH) forming residues; other site 246197008165 trimer interface [polypeptide binding]; other site 246197008166 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 246197008167 Haemolysin-III related; Region: HlyIII; pfam03006 246197008168 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 246197008169 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 246197008170 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 246197008171 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 246197008172 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 246197008173 active site 246197008174 Zn binding site [ion binding]; other site 246197008175 fumarate hydratase; Provisional; Region: PRK15389 246197008176 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 246197008177 Fumarase C-terminus; Region: Fumerase_C; pfam05683 246197008178 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 246197008179 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 246197008180 ligand binding site [chemical binding]; other site 246197008181 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 246197008182 active site 246197008183 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 246197008184 HSP70 interaction site [polypeptide binding]; other site 246197008185 Protein of unknown function (DUF808); Region: DUF808; pfam05661 246197008186 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 246197008187 Prostaglandin dehydrogenases; Region: PGDH; cd05288 246197008188 NAD(P) binding site [chemical binding]; other site 246197008189 substrate binding site [chemical binding]; other site 246197008190 dimer interface [polypeptide binding]; other site 246197008191 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 246197008192 HflK protein; Region: hflK; TIGR01933 246197008193 HflC protein; Region: hflC; TIGR01932 246197008194 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 246197008195 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 246197008196 putative catalytic site [active] 246197008197 putative metal binding site [ion binding]; other site 246197008198 putative phosphate binding site [ion binding]; other site 246197008199 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 246197008200 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246197008201 ATP binding site [chemical binding]; other site 246197008202 putative Mg++ binding site [ion binding]; other site 246197008203 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246197008204 nucleotide binding region [chemical binding]; other site 246197008205 ATP-binding site [chemical binding]; other site 246197008206 Helicase associated domain (HA2); Region: HA2; pfam04408 246197008207 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 246197008208 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 246197008209 Protein of unknown function (DUF2381); Region: DUF2381; pfam09544 246197008210 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197008211 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197008212 active site 246197008213 ATP binding site [chemical binding]; other site 246197008214 substrate binding site [chemical binding]; other site 246197008215 activation loop (A-loop); other site 246197008216 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246197008217 active site 246197008218 ATP binding site [chemical binding]; other site 246197008219 substrate binding site [chemical binding]; other site 246197008220 activation loop (A-loop); other site 246197008221 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 246197008222 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 246197008223 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 246197008224 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 246197008225 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 246197008226 putative active site [active] 246197008227 PhoH-like protein; Region: PhoH; pfam02562 246197008228 Protein of unknown function (DUF493); Region: DUF493; pfam04359 246197008229 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 246197008230 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 246197008231 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 246197008232 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 246197008233 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 246197008234 nucleotide binding site [chemical binding]; other site 246197008235 NEF interaction site [polypeptide binding]; other site 246197008236 SBD interface [polypeptide binding]; other site 246197008237 Protein of unknown function, DUF393; Region: DUF393; pfam04134 246197008238 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197008239 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 246197008240 Walker A motif; other site 246197008241 ATP binding site [chemical binding]; other site 246197008242 Walker B motif; other site 246197008243 arginine finger; other site 246197008244 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 246197008245 metal ion-dependent adhesion site (MIDAS); other site 246197008246 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 246197008247 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 246197008248 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 246197008249 Double zinc ribbon; Region: DZR; pfam12773 246197008250 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 246197008251 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246197008252 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 246197008253 phosphopeptide binding site; other site 246197008254 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246197008255 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197008256 active site 246197008257 ATP binding site [chemical binding]; other site 246197008258 substrate binding site [chemical binding]; other site 246197008259 activation loop (A-loop); other site 246197008260 FHA domain; Region: FHA; pfam00498 246197008261 phosphopeptide binding site; other site 246197008262 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246197008263 phosphopeptide binding site; other site 246197008264 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 246197008265 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 246197008266 Zn2+ binding site [ion binding]; other site 246197008267 Mg2+ binding site [ion binding]; other site 246197008268 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 246197008269 synthetase active site [active] 246197008270 NTP binding site [chemical binding]; other site 246197008271 metal binding site [ion binding]; metal-binding site 246197008272 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 246197008273 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 246197008274 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 246197008275 homotrimer interaction site [polypeptide binding]; other site 246197008276 putative active site [active] 246197008277 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 246197008278 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 246197008279 Thioredoxin; Region: Thioredoxin_4; pfam13462 246197008280 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 246197008281 Thioredoxin; Region: Thioredoxin_4; pfam13462 246197008282 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 246197008283 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 246197008284 CPxP motif; other site 246197008285 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 246197008286 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 246197008287 Walker A/P-loop; other site 246197008288 ATP binding site [chemical binding]; other site 246197008289 Q-loop/lid; other site 246197008290 ABC transporter signature motif; other site 246197008291 Walker B; other site 246197008292 D-loop; other site 246197008293 H-loop/switch region; other site 246197008294 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 246197008295 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 246197008296 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 246197008297 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 246197008298 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197008299 active site 246197008300 phosphorylation site [posttranslational modification] 246197008301 intermolecular recognition site; other site 246197008302 dimerization interface [polypeptide binding]; other site 246197008303 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 246197008304 metal binding site [ion binding]; metal-binding site 246197008305 active site 246197008306 I-site; other site 246197008307 Response regulator receiver domain; Region: Response_reg; pfam00072 246197008308 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197008309 active site 246197008310 phosphorylation site [posttranslational modification] 246197008311 intermolecular recognition site; other site 246197008312 dimerization interface [polypeptide binding]; other site 246197008313 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 246197008314 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197008315 Walker A motif; other site 246197008316 ATP binding site [chemical binding]; other site 246197008317 Walker B motif; other site 246197008318 arginine finger; other site 246197008319 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 246197008320 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 246197008321 putative NAD(P) binding site [chemical binding]; other site 246197008322 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 246197008323 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 246197008324 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246197008325 Coenzyme A binding pocket [chemical binding]; other site 246197008326 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197008327 binding surface 246197008328 TPR repeat; Region: TPR_11; pfam13414 246197008329 TPR motif; other site 246197008330 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 246197008331 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 246197008332 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 246197008333 Prephenate dehydratase; Region: PDT; pfam00800 246197008334 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 246197008335 putative L-Phe binding site [chemical binding]; other site 246197008336 Chorismate mutase type II; Region: CM_2; smart00830 246197008337 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 246197008338 Prephenate dehydratase; Region: PDT; pfam00800 246197008339 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 246197008340 putative L-Phe binding site [chemical binding]; other site 246197008341 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246197008342 Coenzyme A binding pocket [chemical binding]; other site 246197008343 EVE domain; Region: EVE; pfam01878 246197008344 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 246197008345 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 246197008346 SLBB domain; Region: SLBB; pfam10531 246197008347 Chain length determinant protein; Region: Wzz; cl15801 246197008348 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 246197008349 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 246197008350 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 246197008351 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 246197008352 Bacterial sugar transferase; Region: Bac_transf; pfam02397 246197008353 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 246197008354 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 246197008355 phosphate binding site [ion binding]; other site 246197008356 putative substrate binding pocket [chemical binding]; other site 246197008357 dimer interface [polypeptide binding]; other site 246197008358 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 246197008359 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 246197008360 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 246197008361 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246197008362 catalytic residue [active] 246197008363 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 246197008364 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 246197008365 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197008366 TPR motif; other site 246197008367 binding surface 246197008368 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 246197008369 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 246197008370 Phosphotransferase enzyme family; Region: APH; pfam01636 246197008371 putative active site [active] 246197008372 putative substrate binding site [chemical binding]; other site 246197008373 ATP binding site [chemical binding]; other site 246197008374 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 246197008375 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; pfam13640 246197008376 Transcriptional regulators [Transcription]; Region: MarR; COG1846 246197008377 MarR family; Region: MarR_2; pfam12802 246197008378 Protein of unknown function (DUF1428); Region: DUF1428; pfam07237 246197008379 Protein of unknown function (DUF1428); Region: DUF1428; pfam07237 246197008380 Repair protein; Region: Repair_PSII; pfam04536 246197008381 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 246197008382 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 246197008383 periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385 246197008384 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 246197008385 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 246197008386 CcmE; Region: CcmE; pfam03100 246197008387 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 246197008388 CcmB protein; Region: CcmB; cl17444 246197008389 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246197008390 heme ABC exporter, ATP-binding protein CcmA; Region: ccmA; TIGR01189 246197008391 Walker A/P-loop; other site 246197008392 ATP binding site [chemical binding]; other site 246197008393 Q-loop/lid; other site 246197008394 ABC transporter signature motif; other site 246197008395 Walker B; other site 246197008396 D-loop; other site 246197008397 H-loop/switch region; other site 246197008398 Putative catalytic NodB homology domain of a hypothetical protein Ecf1 from Escherichia coli and similar proteins; Region: CE4_Ecf1_like_5s; cd10969 246197008399 putative active site [active] 246197008400 putative metal binding site [ion binding]; other site 246197008401 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 246197008402 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 246197008403 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 246197008404 active site 246197008405 substrate binding site [chemical binding]; other site 246197008406 trimer interface [polypeptide binding]; other site 246197008407 CoA binding site [chemical binding]; other site 246197008408 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246197008409 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 246197008410 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 246197008411 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246197008412 putative homodimer interface [polypeptide binding]; other site 246197008413 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 246197008414 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 246197008415 thiamine phosphate binding site [chemical binding]; other site 246197008416 active site 246197008417 pyrophosphate binding site [ion binding]; other site 246197008418 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 246197008419 ThiS interaction site; other site 246197008420 putative active site [active] 246197008421 tetramer interface [polypeptide binding]; other site 246197008422 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 246197008423 thiS-thiF/thiG interaction site; other site 246197008424 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197008425 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197008426 active site 246197008427 substrate binding site [chemical binding]; other site 246197008428 ATP binding site [chemical binding]; other site 246197008429 activation loop (A-loop); other site 246197008430 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 246197008431 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 246197008432 active site 246197008433 dimer interface [polypeptide binding]; other site 246197008434 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 246197008435 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 246197008436 TAP-like protein; Region: Abhydrolase_4; pfam08386 246197008437 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 246197008438 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 246197008439 oligomer interface [polypeptide binding]; other site 246197008440 metal binding site [ion binding]; metal-binding site 246197008441 metal binding site [ion binding]; metal-binding site 246197008442 putative Cl binding site [ion binding]; other site 246197008443 aspartate ring; other site 246197008444 basic sphincter; other site 246197008445 hydrophobic gate; other site 246197008446 periplasmic entrance; other site 246197008447 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 246197008448 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246197008449 active site 246197008450 motif I; other site 246197008451 motif II; other site 246197008452 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 246197008453 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 246197008454 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 246197008455 putative RNA binding site [nucleotide binding]; other site 246197008456 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197008457 S-adenosylmethionine binding site [chemical binding]; other site 246197008458 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 246197008459 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 246197008460 active site 246197008461 catalytic triad [active] 246197008462 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 246197008463 CAAX protease self-immunity; Region: Abi; pfam02517 246197008464 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 246197008465 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 246197008466 putative acyl-acceptor binding pocket; other site 246197008467 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 246197008468 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 246197008469 active site 246197008470 HIGH motif; other site 246197008471 KMSK motif region; other site 246197008472 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 246197008473 tRNA binding surface [nucleotide binding]; other site 246197008474 anticodon binding site; other site 246197008475 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197008476 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197008477 dimer interface [polypeptide binding]; other site 246197008478 phosphorylation site [posttranslational modification] 246197008479 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197008480 ATP binding site [chemical binding]; other site 246197008481 Mg2+ binding site [ion binding]; other site 246197008482 G-X-G motif; other site 246197008483 Response regulator receiver domain; Region: Response_reg; pfam00072 246197008484 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197008485 active site 246197008486 phosphorylation site [posttranslational modification] 246197008487 intermolecular recognition site; other site 246197008488 dimerization interface [polypeptide binding]; other site 246197008489 HEAT repeats; Region: HEAT_2; pfam13646 246197008490 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 246197008491 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 246197008492 HSP70 interaction site [polypeptide binding]; other site 246197008493 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 246197008494 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 246197008495 Zn binding sites [ion binding]; other site 246197008496 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 246197008497 dimer interface [polypeptide binding]; other site 246197008498 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 246197008499 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246197008500 Coenzyme A binding pocket [chemical binding]; other site 246197008501 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 246197008502 S17 interaction site [polypeptide binding]; other site 246197008503 S8 interaction site; other site 246197008504 16S rRNA interaction site [nucleotide binding]; other site 246197008505 streptomycin interaction site [chemical binding]; other site 246197008506 23S rRNA interaction site [nucleotide binding]; other site 246197008507 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 246197008508 30S ribosomal protein S7; Validated; Region: PRK05302 246197008509 elongation factor G; Reviewed; Region: PRK00007 246197008510 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 246197008511 G1 box; other site 246197008512 putative GEF interaction site [polypeptide binding]; other site 246197008513 GTP/Mg2+ binding site [chemical binding]; other site 246197008514 Switch I region; other site 246197008515 G2 box; other site 246197008516 G3 box; other site 246197008517 Switch II region; other site 246197008518 G4 box; other site 246197008519 G5 box; other site 246197008520 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 246197008521 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 246197008522 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 246197008523 elongation factor Tu; Reviewed; Region: PRK00049 246197008524 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 246197008525 G1 box; other site 246197008526 GEF interaction site [polypeptide binding]; other site 246197008527 GTP/Mg2+ binding site [chemical binding]; other site 246197008528 Switch I region; other site 246197008529 G2 box; other site 246197008530 G3 box; other site 246197008531 Switch II region; other site 246197008532 G4 box; other site 246197008533 G5 box; other site 246197008534 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 246197008535 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 246197008536 Antibiotic Binding Site [chemical binding]; other site 246197008537 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 246197008538 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 246197008539 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 246197008540 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 246197008541 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 246197008542 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 246197008543 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 246197008544 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 246197008545 putative translocon binding site; other site 246197008546 protein-rRNA interface [nucleotide binding]; other site 246197008547 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 246197008548 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 246197008549 G-X-X-G motif; other site 246197008550 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 246197008551 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 246197008552 23S rRNA interface [nucleotide binding]; other site 246197008553 5S rRNA interface [nucleotide binding]; other site 246197008554 putative antibiotic binding site [chemical binding]; other site 246197008555 L25 interface [polypeptide binding]; other site 246197008556 L27 interface [polypeptide binding]; other site 246197008557 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 246197008558 23S rRNA interface [nucleotide binding]; other site 246197008559 putative translocon interaction site; other site 246197008560 signal recognition particle (SRP54) interaction site; other site 246197008561 L23 interface [polypeptide binding]; other site 246197008562 trigger factor interaction site; other site 246197008563 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 246197008564 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 246197008565 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 246197008566 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 246197008567 RNA binding site [nucleotide binding]; other site 246197008568 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 246197008569 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 246197008570 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 246197008571 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 246197008572 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 246197008573 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 246197008574 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 246197008575 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 246197008576 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 246197008577 5S rRNA interface [nucleotide binding]; other site 246197008578 L27 interface [polypeptide binding]; other site 246197008579 23S rRNA interface [nucleotide binding]; other site 246197008580 L5 interface [polypeptide binding]; other site 246197008581 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 246197008582 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 246197008583 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 246197008584 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 246197008585 23S rRNA binding site [nucleotide binding]; other site 246197008586 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 246197008587 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 246197008588 SecY translocase; Region: SecY; pfam00344 246197008589 adenylate kinase; Reviewed; Region: adk; PRK00279 246197008590 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 246197008591 AMP-binding site [chemical binding]; other site 246197008592 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 246197008593 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 246197008594 rRNA binding site [nucleotide binding]; other site 246197008595 predicted 30S ribosome binding site; other site 246197008596 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 246197008597 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 246197008598 30S ribosomal protein S13; Region: bact_S13; TIGR03631 246197008599 30S ribosomal protein S11; Validated; Region: PRK05309 246197008600 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 246197008601 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 246197008602 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 246197008603 RNA binding surface [nucleotide binding]; other site 246197008604 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 246197008605 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 246197008606 alphaNTD homodimer interface [polypeptide binding]; other site 246197008607 alphaNTD - beta interaction site [polypeptide binding]; other site 246197008608 alphaNTD - beta' interaction site [polypeptide binding]; other site 246197008609 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 246197008610 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 246197008611 TPR repeat; Region: TPR_11; pfam13414 246197008612 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197008613 TPR motif; other site 246197008614 binding surface 246197008615 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197008616 TPR motif; other site 246197008617 TPR repeat; Region: TPR_11; pfam13414 246197008618 binding surface 246197008619 TPR repeat; Region: TPR_11; pfam13414 246197008620 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197008621 binding surface 246197008622 TPR motif; other site 246197008623 TPR repeat; Region: TPR_11; pfam13414 246197008624 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 246197008625 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 246197008626 putative acyl-acceptor binding pocket; other site 246197008627 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 246197008628 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 246197008629 Substrate-binding site [chemical binding]; other site 246197008630 Substrate specificity [chemical binding]; other site 246197008631 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246197008632 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 246197008633 phosphopeptide binding site; other site 246197008634 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 246197008635 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197008636 Walker A motif; other site 246197008637 ATP binding site [chemical binding]; other site 246197008638 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 246197008639 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 246197008640 EamA-like transporter family; Region: EamA; pfam00892 246197008641 EamA-like transporter family; Region: EamA; pfam00892 246197008642 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 246197008643 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 246197008644 NAD-dependent deacetylase; Provisional; Region: PRK00481 246197008645 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 246197008646 NAD+ binding site [chemical binding]; other site 246197008647 substrate binding site [chemical binding]; other site 246197008648 Zn binding site [ion binding]; other site 246197008649 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197008650 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197008651 active site 246197008652 ATP binding site [chemical binding]; other site 246197008653 substrate binding site [chemical binding]; other site 246197008654 activation loop (A-loop); other site 246197008655 PEGA domain; Region: PEGA; pfam08308 246197008656 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 246197008657 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 246197008658 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 246197008659 ABC transporter; Region: ABC_tran_2; pfam12848 246197008660 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 246197008661 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 246197008662 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 246197008663 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 246197008664 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 246197008665 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 246197008666 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197008667 phosphorylation site [posttranslational modification] 246197008668 dimer interface [polypeptide binding]; other site 246197008669 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197008670 ATP binding site [chemical binding]; other site 246197008671 Mg2+ binding site [ion binding]; other site 246197008672 G-X-G motif; other site 246197008673 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 246197008674 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 246197008675 N-acetyl-D-glucosamine binding site [chemical binding]; other site 246197008676 catalytic residue [active] 246197008677 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 246197008678 DNA-binding site [nucleotide binding]; DNA binding site 246197008679 RNA-binding motif; other site 246197008680 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 246197008681 L-seryl-tRNA selenium transferase; Region: SelA; pfam03841 246197008682 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 246197008683 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 246197008684 active site 246197008685 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 246197008686 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 246197008687 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 246197008688 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 246197008689 HSP70 interaction site [polypeptide binding]; other site 246197008690 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246197008691 non-specific DNA binding site [nucleotide binding]; other site 246197008692 salt bridge; other site 246197008693 sequence-specific DNA binding site [nucleotide binding]; other site 246197008694 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 246197008695 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 246197008696 RNA binding surface [nucleotide binding]; other site 246197008697 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 246197008698 active site 246197008699 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 246197008700 HEAT repeats; Region: HEAT_2; pfam13646 246197008701 OPT oligopeptide transporter protein; Region: OPT; cl14607 246197008702 OPT oligopeptide transporter protein; Region: OPT; cl14607 246197008703 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 246197008704 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246197008705 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246197008706 DNA binding residues [nucleotide binding] 246197008707 Domain of unknown function (DUF3488); Region: DUF3488; pfam11992 246197008708 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 246197008709 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 246197008710 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 246197008711 Protein of unknown function DUF58; Region: DUF58; pfam01882 246197008712 MoxR-like ATPases [General function prediction only]; Region: COG0714 246197008713 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 246197008714 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197008715 Walker A motif; other site 246197008716 ATP binding site [chemical binding]; other site 246197008717 Walker B motif; other site 246197008718 arginine finger; other site 246197008719 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 246197008720 anti sigma factor interaction site; other site 246197008721 regulatory phosphorylation site [posttranslational modification]; other site 246197008722 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 246197008723 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 246197008724 N-acetyl-D-glucosamine binding site [chemical binding]; other site 246197008725 catalytic residue [active] 246197008726 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 246197008727 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 246197008728 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 246197008729 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003 246197008730 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 246197008731 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197008732 TPR motif; other site 246197008733 binding surface 246197008734 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197008735 binding surface 246197008736 TPR motif; other site 246197008737 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197008738 TPR motif; other site 246197008739 Tetratricopeptide repeat; Region: TPR_12; pfam13424 246197008740 binding surface 246197008741 Tetratricopeptide repeat; Region: TPR_12; pfam13424 246197008742 TPR repeat; Region: TPR_11; pfam13414 246197008743 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197008744 binding surface 246197008745 TPR motif; other site 246197008746 TPR repeat; Region: TPR_11; pfam13414 246197008747 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246197008748 phosphopeptide binding site; other site 246197008749 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 246197008750 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 246197008751 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 246197008752 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 246197008753 G1 box; other site 246197008754 putative GEF interaction site [polypeptide binding]; other site 246197008755 GTP/Mg2+ binding site [chemical binding]; other site 246197008756 Switch I region; other site 246197008757 G2 box; other site 246197008758 G3 box; other site 246197008759 Switch II region; other site 246197008760 G4 box; other site 246197008761 G5 box; other site 246197008762 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 246197008763 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 246197008764 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246197008765 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 246197008766 G4 box; other site 246197008767 G5 box; other site 246197008768 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 246197008769 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197008770 Walker A motif; other site 246197008771 ATP binding site [chemical binding]; other site 246197008772 Walker B motif; other site 246197008773 arginine finger; other site 246197008774 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 246197008775 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 246197008776 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 246197008777 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 246197008778 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197008779 S-adenosylmethionine binding site [chemical binding]; other site 246197008780 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 246197008781 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 246197008782 active site 246197008783 (T/H)XGH motif; other site 246197008784 aspartate aminotransferase; Provisional; Region: PRK05764 246197008785 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246197008786 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246197008787 homodimer interface [polypeptide binding]; other site 246197008788 catalytic residue [active] 246197008789 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 246197008790 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 246197008791 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 246197008792 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 246197008793 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 246197008794 ATP-grasp domain; Region: ATP-grasp_4; cl17255 246197008795 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 246197008796 IMP binding site; other site 246197008797 dimer interface [polypeptide binding]; other site 246197008798 interdomain contacts; other site 246197008799 partial ornithine binding site; other site 246197008800 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 246197008801 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 246197008802 active site 246197008803 FMN binding site [chemical binding]; other site 246197008804 substrate binding site [chemical binding]; other site 246197008805 putative catalytic residue [active] 246197008806 Fatty acid desaturase; Region: FA_desaturase; pfam00487 246197008807 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 246197008808 putative di-iron ligands [ion binding]; other site 246197008809 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 246197008810 putative hydrophobic ligand binding site [chemical binding]; other site 246197008811 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 246197008812 dinuclear metal binding motif [ion binding]; other site 246197008813 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 246197008814 active site 246197008815 catalytic residues [active] 246197008816 metal binding site [ion binding]; metal-binding site 246197008817 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 246197008818 CoenzymeA binding site [chemical binding]; other site 246197008819 subunit interaction site [polypeptide binding]; other site 246197008820 PHB binding site; other site 246197008821 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 246197008822 hypothetical protein; Provisional; Region: PRK07236 246197008823 hypothetical protein; Provisional; Region: PRK06753 246197008824 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 246197008825 conserved hypothetical protein; Region: TIGR02231 246197008826 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 246197008827 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 246197008828 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 246197008829 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 246197008830 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 246197008831 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 246197008832 DNA binding site [nucleotide binding] 246197008833 active site 246197008834 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 246197008835 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246197008836 phosphopeptide binding site; other site 246197008837 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 246197008838 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 246197008839 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 246197008840 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 246197008841 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 246197008842 ssDNA binding site; other site 246197008843 generic binding surface II; other site 246197008844 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246197008845 ATP binding site [chemical binding]; other site 246197008846 putative Mg++ binding site [ion binding]; other site 246197008847 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246197008848 nucleotide binding region [chemical binding]; other site 246197008849 ATP-binding site [chemical binding]; other site 246197008850 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 246197008851 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197008852 S-adenosylmethionine binding site [chemical binding]; other site 246197008853 threonine synthase; Region: PLN02569 246197008854 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 246197008855 homodimer interface [polypeptide binding]; other site 246197008856 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246197008857 catalytic residue [active] 246197008858 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 246197008859 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 246197008860 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 246197008861 dimerization interface [polypeptide binding]; other site 246197008862 active site 246197008863 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 246197008864 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 246197008865 TMP-binding site; other site 246197008866 ATP-binding site [chemical binding]; other site 246197008867 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 246197008868 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 246197008869 YHS domain; Region: YHS; pfam04945 246197008870 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 246197008871 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 246197008872 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246197008873 motif II; other site 246197008874 Domain of unknown function (DUF305); Region: DUF305; pfam03713 246197008875 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 246197008876 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 246197008877 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 246197008878 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197008879 active site 246197008880 phosphorylation site [posttranslational modification] 246197008881 intermolecular recognition site; other site 246197008882 dimerization interface [polypeptide binding]; other site 246197008883 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197008884 Walker A motif; other site 246197008885 ATP binding site [chemical binding]; other site 246197008886 Walker B motif; other site 246197008887 arginine finger; other site 246197008888 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 246197008889 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246197008890 dimerization interface [polypeptide binding]; other site 246197008891 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197008892 dimer interface [polypeptide binding]; other site 246197008893 phosphorylation site [posttranslational modification] 246197008894 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197008895 ATP binding site [chemical binding]; other site 246197008896 Mg2+ binding site [ion binding]; other site 246197008897 G-X-G motif; other site 246197008898 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 246197008899 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 246197008900 Multicopper oxidase; Region: Cu-oxidase; pfam00394 246197008901 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 246197008902 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 246197008903 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 246197008904 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 246197008905 metal-binding site [ion binding] 246197008906 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 246197008907 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246197008908 motif II; other site 246197008909 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 246197008910 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 246197008911 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 246197008912 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 246197008913 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 246197008914 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 246197008915 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246197008916 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 246197008917 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 246197008918 metal-binding site [ion binding] 246197008919 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 246197008920 Sulfatase; Region: Sulfatase; pfam00884 246197008921 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 246197008922 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 246197008923 conserved cys residue [active] 246197008924 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246197008925 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 246197008926 CoenzymeA binding site [chemical binding]; other site 246197008927 subunit interaction site [polypeptide binding]; other site 246197008928 PHB binding site; other site 246197008929 Outer membrane efflux protein; Region: OEP; pfam02321 246197008930 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 246197008931 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 246197008932 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 246197008933 Predicted ATPase [General function prediction only]; Region: COG3911 246197008934 AAA domain; Region: AAA_28; pfam13521 246197008935 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 246197008936 competence damage-inducible protein A; Provisional; Region: PRK01215 246197008937 MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451 246197008938 MPT binding site; other site 246197008939 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197008940 binding surface 246197008941 TPR motif; other site 246197008942 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197008943 TPR motif; other site 246197008944 binding surface 246197008945 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197008946 binding surface 246197008947 TPR motif; other site 246197008948 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 246197008949 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 246197008950 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 246197008951 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 246197008952 active site 246197008953 Zn binding site [ion binding]; other site 246197008954 Domain of unknown function (DUF4136); Region: DUF4136; pfam13590 246197008955 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 246197008956 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 246197008957 iron-sulfur cluster [ion binding]; other site 246197008958 [2Fe-2S] cluster binding site [ion binding]; other site 246197008959 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 246197008960 hydrophobic ligand binding site; other site 246197008961 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246197008962 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246197008963 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246197008964 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246197008965 putative substrate translocation pore; other site 246197008966 OpgC protein; Region: OpgC_C; pfam10129 246197008967 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 246197008968 HlyD family secretion protein; Region: HlyD_3; pfam13437 246197008969 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 246197008970 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 246197008971 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197008972 active site 246197008973 phosphorylation site [posttranslational modification] 246197008974 intermolecular recognition site; other site 246197008975 dimerization interface [polypeptide binding]; other site 246197008976 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 246197008977 DNA binding site [nucleotide binding] 246197008978 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197008979 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197008980 ATP binding site [chemical binding]; other site 246197008981 Mg2+ binding site [ion binding]; other site 246197008982 G-X-G motif; other site 246197008983 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 246197008984 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 246197008985 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 246197008986 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246197008987 Walker A/P-loop; other site 246197008988 ATP binding site [chemical binding]; other site 246197008989 Q-loop/lid; other site 246197008990 ABC transporter signature motif; other site 246197008991 Walker B; other site 246197008992 D-loop; other site 246197008993 H-loop/switch region; other site 246197008994 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 246197008995 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 246197008996 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 246197008997 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 246197008998 dimer interface [polypeptide binding]; other site 246197008999 putative CheW interface [polypeptide binding]; other site 246197009000 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 246197009001 Uncharacterized conserved protein [Function unknown]; Region: COG1262 246197009002 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 246197009003 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 246197009004 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246197009005 FeS/SAM binding site; other site 246197009006 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 246197009007 polyketide-type polyunsaturated fatty acid synthase PfaA; Region: omega_3_PfaA; TIGR02813 246197009008 Uncharacterized conserved protein [Function unknown]; Region: COG3791 246197009009 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 246197009010 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 246197009011 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 246197009012 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197009013 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08063 246197009014 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 246197009015 putative NAD(P) binding site [chemical binding]; other site 246197009016 active site 246197009017 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 246197009018 active site 246197009019 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 246197009020 Acyl transferase domain; Region: Acyl_transf_1; cl08282 246197009021 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 246197009022 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246197009023 active site 246197009024 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246197009025 NAD(P) binding site [chemical binding]; other site 246197009026 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 246197009027 active site 246197009028 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 246197009029 Fatty acid desaturase; Region: FA_desaturase; pfam00487 246197009030 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 246197009031 putative di-iron ligands [ion binding]; other site 246197009032 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 246197009033 active site 246197009034 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 246197009035 active sites [active] 246197009036 tetramer interface [polypeptide binding]; other site 246197009037 aspartate kinase; Reviewed; Region: PRK06635 246197009038 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 246197009039 putative catalytic residues [active] 246197009040 putative nucleotide binding site [chemical binding]; other site 246197009041 putative aspartate binding site [chemical binding]; other site 246197009042 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 246197009043 putative allosteric regulatory site; other site 246197009044 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 246197009045 putative allosteric regulatory residue; other site 246197009046 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 246197009047 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 246197009048 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 246197009049 CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439 246197009050 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 246197009051 DXD motif; other site 246197009052 CHAP domain; Region: CHAP; cl17642 246197009053 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 246197009054 Part of AAA domain; Region: AAA_19; pfam13245 246197009055 Family description; Region: UvrD_C_2; pfam13538 246197009056 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 246197009057 nucleotide binding site [chemical binding]; other site 246197009058 SCP-2 sterol transfer family; Region: SCP2; cl01225 246197009059 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 246197009060 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 246197009061 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 246197009062 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 246197009063 iron-sulfur cluster [ion binding]; other site 246197009064 [2Fe-2S] cluster binding site [ion binding]; other site 246197009065 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 246197009066 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 246197009067 DXD motif; other site 246197009068 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 246197009069 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 246197009070 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 246197009071 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 246197009072 ligand-binding site [chemical binding]; other site 246197009073 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 246197009074 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 246197009075 Predicted membrane protein (DUF2070); Region: DUF2070; pfam09843 246197009076 Lipoxygenase; Region: Lipoxygenase; pfam00305 246197009077 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 246197009078 Fatty acid desaturase; Region: FA_desaturase; pfam00487 246197009079 putative di-iron ligands [ion binding]; other site 246197009080 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 246197009081 Bacterial transcriptional activator domain; Region: BTAD; smart01043 246197009082 AAA ATPase domain; Region: AAA_16; pfam13191 246197009083 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 246197009084 active site 246197009085 NTP binding site [chemical binding]; other site 246197009086 metal binding triad [ion binding]; metal-binding site 246197009087 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 246197009088 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 246197009089 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 246197009090 Ligand Binding Site [chemical binding]; other site 246197009091 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 246197009092 IHF dimer interface [polypeptide binding]; other site 246197009093 IHF - DNA interface [nucleotide binding]; other site 246197009094 Sporulation related domain; Region: SPOR; pfam05036 246197009095 Cupin domain; Region: Cupin_2; cl17218 246197009096 MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins constitute a family of proteins that share the methyl-CpG-binding domain (MBD). The MBD consists of about 70 residues and is defined as the minimal region required for binding to...; Region: MBD; cl00110 246197009097 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 246197009098 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 246197009099 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 246197009100 NAD binding site [chemical binding]; other site 246197009101 putative substrate binding site 2 [chemical binding]; other site 246197009102 putative substrate binding site 1 [chemical binding]; other site 246197009103 active site 246197009104 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 246197009105 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246197009106 NAD(P) binding site [chemical binding]; other site 246197009107 active site 246197009108 GTP-binding protein LepA; Provisional; Region: PRK05433 246197009109 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 246197009110 G1 box; other site 246197009111 putative GEF interaction site [polypeptide binding]; other site 246197009112 GTP/Mg2+ binding site [chemical binding]; other site 246197009113 Switch I region; other site 246197009114 G2 box; other site 246197009115 G3 box; other site 246197009116 Switch II region; other site 246197009117 G4 box; other site 246197009118 G5 box; other site 246197009119 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 246197009120 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 246197009121 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 246197009122 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 246197009123 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 246197009124 Catalytic site [active] 246197009125 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 246197009126 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 246197009127 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 246197009128 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 246197009129 dihydroorotase; Validated; Region: pyrC; PRK09357 246197009130 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246197009131 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 246197009132 active site 246197009133 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 246197009134 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 246197009135 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 246197009136 catalytic site [active] 246197009137 subunit interface [polypeptide binding]; other site 246197009138 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 246197009139 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 246197009140 domain interfaces; other site 246197009141 active site 246197009142 Bifunctional nuclease; Region: DNase-RNase; pfam02577 246197009143 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 246197009144 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246197009145 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246197009146 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 246197009147 acyl-activating enzyme (AAE) consensus motif; other site 246197009148 acyl-activating enzyme (AAE) consensus motif; other site 246197009149 putative AMP binding site [chemical binding]; other site 246197009150 putative active site [active] 246197009151 putative CoA binding site [chemical binding]; other site 246197009152 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 246197009153 Citrate synthase; Region: Citrate_synt; pfam00285 246197009154 oxalacetate binding site [chemical binding]; other site 246197009155 citrylCoA binding site [chemical binding]; other site 246197009156 coenzyme A binding site [chemical binding]; other site 246197009157 catalytic triad [active] 246197009158 5-enolpyruvylshikimate-3-phosphate synthase [Amino acid transport and metabolism]; Region: AroA; COG0128 246197009159 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 246197009160 putative active site [active] 246197009161 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 246197009162 active site 246197009163 NAD binding site [chemical binding]; other site 246197009164 metal binding site [ion binding]; metal-binding site 246197009165 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 246197009166 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 246197009167 Tetramer interface [polypeptide binding]; other site 246197009168 active site 246197009169 FMN-binding site [chemical binding]; other site 246197009170 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 246197009171 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 246197009172 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 246197009173 active site 246197009174 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 246197009175 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197009176 S-adenosylmethionine binding site [chemical binding]; other site 246197009177 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 246197009178 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 246197009179 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 246197009180 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 246197009181 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 246197009182 dimer interface [polypeptide binding]; other site 246197009183 tetramer interface [polypeptide binding]; other site 246197009184 PYR/PP interface [polypeptide binding]; other site 246197009185 TPP binding site [chemical binding]; other site 246197009186 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 246197009187 TPP-binding site; other site 246197009188 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 246197009189 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 246197009190 UbiA prenyltransferase family; Region: UbiA; pfam01040 246197009191 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 246197009192 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 246197009193 metal binding site [ion binding]; metal-binding site 246197009194 substrate binding pocket [chemical binding]; other site 246197009195 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK03640 246197009196 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 246197009197 acyl-activating enzyme (AAE) consensus motif; other site 246197009198 putative AMP binding site [chemical binding]; other site 246197009199 putative active site [active] 246197009200 putative CoA binding site [chemical binding]; other site 246197009201 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 246197009202 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 246197009203 isocitrate dehydrogenase; Validated; Region: PRK07362 246197009204 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 246197009205 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 246197009206 malate dehydrogenase; Reviewed; Region: PRK06223 246197009207 dimer interface [polypeptide binding]; other site 246197009208 NAD(P) binding site [chemical binding]; other site 246197009209 tetramer (dimer of dimers) interface [polypeptide binding]; other site 246197009210 substrate binding site [chemical binding]; other site 246197009211 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 246197009212 L-aspartate oxidase; Provisional; Region: PRK06175 246197009213 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 246197009214 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 246197009215 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 246197009216 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 246197009217 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 246197009218 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 246197009219 CoA-ligase; Region: Ligase_CoA; pfam00549 246197009220 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 246197009221 CoA binding domain; Region: CoA_binding; smart00881 246197009222 CoA-ligase; Region: Ligase_CoA; pfam00549 246197009223 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 246197009224 active site 246197009225 multimer interface [polypeptide binding]; other site 246197009226 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 246197009227 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246197009228 FeS/SAM binding site; other site 246197009229 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14525 246197009230 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 246197009231 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 246197009232 G-X-X-G motif; other site 246197009233 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 246197009234 RimM N-terminal domain; Region: RimM; pfam01782 246197009235 PRC-barrel domain; Region: PRC; pfam05239 246197009236 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 246197009237 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 246197009238 AAA domain; Region: AAA_27; pfam13514 246197009239 hypothetical protein; Reviewed; Region: PRK12497 246197009240 Predicted methyltransferases [General function prediction only]; Region: COG0313 246197009241 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 246197009242 putative SAM binding site [chemical binding]; other site 246197009243 putative homodimer interface [polypeptide binding]; other site 246197009244 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 246197009245 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 246197009246 Peptidase family M23; Region: Peptidase_M23; pfam01551 246197009247 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 246197009248 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197009249 active site 246197009250 phosphorylation site [posttranslational modification] 246197009251 intermolecular recognition site; other site 246197009252 dimerization interface [polypeptide binding]; other site 246197009253 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197009254 Walker A motif; other site 246197009255 ATP binding site [chemical binding]; other site 246197009256 Walker B motif; other site 246197009257 arginine finger; other site 246197009258 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 246197009259 Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454 246197009260 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 246197009261 diiron binding motif [ion binding]; other site 246197009262 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 246197009263 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 246197009264 30S ribosomal protein S1; Provisional; Region: rpsA; PRK13806 246197009265 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 246197009266 RNA binding site [nucleotide binding]; other site 246197009267 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 246197009268 RNA binding site [nucleotide binding]; other site 246197009269 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 246197009270 RNA binding site [nucleotide binding]; other site 246197009271 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 246197009272 RNA binding site [nucleotide binding]; other site 246197009273 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 246197009274 RNA binding site [nucleotide binding]; other site 246197009275 phenylcoumaran benzylic ether reductase (PCBER) like, atypical (a) SDRs; Region: PCBER_SDR_a; cd05259 246197009276 NmrA-like family; Region: NmrA; pfam05368 246197009277 NAD(P) binding site [chemical binding]; other site 246197009278 active site lysine 246197009279 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 246197009280 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 246197009281 PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818 246197009282 PA/protease or protease-like domain interface [polypeptide binding]; other site 246197009283 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 246197009284 Zn binding site [ion binding]; other site 246197009285 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 246197009286 REJ domain; Region: REJ; pfam02010 246197009287 Patatin-like phospholipase; Region: Patatin; pfam01734 246197009288 amidase; Provisional; Region: PRK08137 246197009289 Amidase; Region: Amidase; pfam01425 246197009290 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 246197009291 Putative 2OG-Fe(II) oxygenase; Region: 2OG-FeII_Oxy_5; cl17879 246197009292 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197009293 S-adenosylmethionine binding site [chemical binding]; other site 246197009294 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 246197009295 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 246197009296 ATPase involved in DNA repair; Region: DUF3686; pfam12458 246197009297 AAA domain; Region: AAA_22; pfam13401 246197009298 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197009299 Walker A motif; other site 246197009300 ATP binding site [chemical binding]; other site 246197009301 Walker B motif; other site 246197009302 arginine finger; other site 246197009303 Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305 246197009304 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 246197009305 von Willebrand factor; Region: vWF_A; pfam12450 246197009306 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 246197009307 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 246197009308 metal ion-dependent adhesion site (MIDAS); other site 246197009309 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 246197009310 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 246197009311 dimer interface [polypeptide binding]; other site 246197009312 substrate binding site [chemical binding]; other site 246197009313 metal binding site [ion binding]; metal-binding site 246197009314 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 246197009315 Acyltransferase family; Region: Acyl_transf_3; pfam01757 246197009316 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 246197009317 active site 246197009318 metal binding site [ion binding]; metal-binding site 246197009319 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 246197009320 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 246197009321 active site 246197009322 metal binding site [ion binding]; metal-binding site 246197009323 short chain dehydrogenase; Provisional; Region: PRK08303 246197009324 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246197009325 NAD(P) binding site [chemical binding]; other site 246197009326 active site 246197009327 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 246197009328 Peptidase family M2 Angiotensin converting enzyme (ACE); Region: M2_ACE; cd06461 246197009329 active site 246197009330 Zn binding site [ion binding]; other site 246197009331 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 246197009332 DNA-binding site [nucleotide binding]; DNA binding site 246197009333 RNA-binding motif; other site 246197009334 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 246197009335 Zn binding site [ion binding]; other site 246197009336 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 246197009337 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 246197009338 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 246197009339 PilZ domain; Region: PilZ; pfam07238 246197009340 PEGA domain; Region: PEGA; pfam08308 246197009341 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 246197009342 Domain of unknown function DUF20; Region: UPF0118; pfam01594 246197009343 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 246197009344 Fe-S cluster binding site [ion binding]; other site 246197009345 DNA binding site [nucleotide binding] 246197009346 active site 246197009347 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 246197009348 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 246197009349 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 246197009350 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 246197009351 active site 246197009352 dimer interface [polypeptide binding]; other site 246197009353 motif 1; other site 246197009354 motif 2; other site 246197009355 motif 3; other site 246197009356 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 246197009357 anticodon binding site; other site 246197009358 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 246197009359 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 246197009360 23S rRNA binding site [nucleotide binding]; other site 246197009361 L21 binding site [polypeptide binding]; other site 246197009362 L13 binding site [polypeptide binding]; other site 246197009363 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 246197009364 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 246197009365 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 246197009366 dimer interface [polypeptide binding]; other site 246197009367 motif 1; other site 246197009368 active site 246197009369 motif 2; other site 246197009370 motif 3; other site 246197009371 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 246197009372 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 246197009373 putative tRNA-binding site [nucleotide binding]; other site 246197009374 B3/4 domain; Region: B3_4; pfam03483 246197009375 tRNA synthetase B5 domain; Region: B5; smart00874 246197009376 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 246197009377 dimer interface [polypeptide binding]; other site 246197009378 motif 1; other site 246197009379 motif 3; other site 246197009380 motif 2; other site 246197009381 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 246197009382 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 246197009383 IHF dimer interface [polypeptide binding]; other site 246197009384 IHF - DNA interface [nucleotide binding]; other site 246197009385 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 246197009386 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 246197009387 cofactor binding site; other site 246197009388 DNA binding site [nucleotide binding] 246197009389 substrate interaction site [chemical binding]; other site 246197009390 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 246197009391 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 246197009392 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 246197009393 additional DNA contacts [nucleotide binding]; other site 246197009394 mismatch recognition site; other site 246197009395 active site 246197009396 zinc binding site [ion binding]; other site 246197009397 DNA intercalation site [nucleotide binding]; other site 246197009398 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 246197009399 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197009400 ATP binding site [chemical binding]; other site 246197009401 Mg2+ binding site [ion binding]; other site 246197009402 G-X-G motif; other site 246197009403 Z1 domain; Region: Z1; pfam10593 246197009404 Domain of unknown function (DUF4420); Region: DUF4420; pfam14390 246197009405 AIPR protein; Region: AIPR; pfam10592 246197009406 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 246197009407 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197009408 active site 246197009409 phosphorylation site [posttranslational modification] 246197009410 intermolecular recognition site; other site 246197009411 dimerization interface [polypeptide binding]; other site 246197009412 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 246197009413 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197009414 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197009415 ATP binding site [chemical binding]; other site 246197009416 Mg2+ binding site [ion binding]; other site 246197009417 G-X-G motif; other site 246197009418 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 246197009419 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 246197009420 putative active site [active] 246197009421 putative NTP binding site [chemical binding]; other site 246197009422 putative nucleic acid binding site [nucleotide binding]; other site 246197009423 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 246197009424 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 246197009425 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197009426 Walker A motif; other site 246197009427 ATP binding site [chemical binding]; other site 246197009428 Walker B motif; other site 246197009429 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 246197009430 Integrase core domain; Region: rve; pfam00665 246197009431 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 246197009432 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 246197009433 Integrase core domain; Region: rve; pfam00665 246197009434 Integrase core domain; Region: rve_3; cl15866 246197009435 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197009436 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 246197009437 Walker A motif; other site 246197009438 ATP binding site [chemical binding]; other site 246197009439 Walker B motif; other site 246197009440 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 246197009441 Condensation domain; Region: Condensation; pfam00668 246197009442 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197009443 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197009444 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 246197009445 acyl-activating enzyme (AAE) consensus motif; other site 246197009446 AMP binding site [chemical binding]; other site 246197009447 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197009448 Condensation domain; Region: Condensation; pfam00668 246197009449 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246197009450 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 246197009451 acyl-activating enzyme (AAE) consensus motif; other site 246197009452 AMP binding site [chemical binding]; other site 246197009453 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197009454 Condensation domain; Region: Condensation; pfam00668 246197009455 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197009456 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197009457 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 246197009458 acyl-activating enzyme (AAE) consensus motif; other site 246197009459 AMP binding site [chemical binding]; other site 246197009460 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197009461 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 246197009462 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246197009463 acyl-activating enzyme (AAE) consensus motif; other site 246197009464 AMP binding site [chemical binding]; other site 246197009465 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197009466 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246197009467 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 246197009468 active site 246197009469 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 246197009470 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 246197009471 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 246197009472 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 246197009473 putative NADP binding site [chemical binding]; other site 246197009474 active site 246197009475 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197009476 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 246197009477 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246197009478 active site 246197009479 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 246197009480 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 246197009481 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 246197009482 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 246197009483 putative NADP binding site [chemical binding]; other site 246197009484 active site 246197009485 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197009486 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246197009487 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 246197009488 active site 246197009489 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 246197009490 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 246197009491 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197009492 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 246197009493 GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of...; Region: GST_N_Sigma_like; cd03039 246197009494 glutathione s-transferase; Provisional; Region: PTZ00057 246197009495 GSH binding site (G-site) [chemical binding]; other site 246197009496 C-terminal domain interface [polypeptide binding]; other site 246197009497 dimer interface [polypeptide binding]; other site 246197009498 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 246197009499 N-terminal domain interface [polypeptide binding]; other site 246197009500 dimer interface [polypeptide binding]; other site 246197009501 substrate binding pocket (H-site) [chemical binding]; other site 246197009502 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 246197009503 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 246197009504 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 246197009505 Cupin-like domain; Region: Cupin_8; pfam13621 246197009506 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 246197009507 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 246197009508 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246197009509 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246197009510 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 246197009511 active site 246197009512 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 246197009513 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197009514 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 246197009515 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246197009516 active site 246197009517 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 246197009518 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 246197009519 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 246197009520 putative NADP binding site [chemical binding]; other site 246197009521 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 246197009522 active site 246197009523 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197009524 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 246197009525 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 246197009526 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 246197009527 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 246197009528 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 246197009529 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 246197009530 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 246197009531 acyl-activating enzyme (AAE) consensus motif; other site 246197009532 active site 246197009533 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197009534 Condensation domain; Region: Condensation; pfam00668 246197009535 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197009536 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197009537 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246197009538 acyl-activating enzyme (AAE) consensus motif; other site 246197009539 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 246197009540 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 246197009541 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246197009542 AMP binding site [chemical binding]; other site 246197009543 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197009544 Condensation domain; Region: Condensation; pfam00668 246197009545 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197009546 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197009547 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246197009548 acyl-activating enzyme (AAE) consensus motif; other site 246197009549 AMP binding site [chemical binding]; other site 246197009550 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197009551 Condensation domain; Region: Condensation; pfam00668 246197009552 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 246197009553 Condensation domain; Region: Condensation; pfam00668 246197009554 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197009555 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 246197009556 acyl-activating enzyme (AAE) consensus motif; other site 246197009557 AMP binding site [chemical binding]; other site 246197009558 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197009559 Condensation domain; Region: Condensation; pfam00668 246197009560 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197009561 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197009562 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 246197009563 acyl-activating enzyme (AAE) consensus motif; other site 246197009564 AMP binding site [chemical binding]; other site 246197009565 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197009566 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246197009567 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 246197009568 active site 246197009569 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 246197009570 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 246197009571 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197009572 Condensation domain; Region: Condensation; pfam00668 246197009573 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197009574 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197009575 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246197009576 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 246197009577 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 246197009578 Condensation domain; Region: Condensation; pfam00668 246197009579 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197009580 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197009581 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246197009582 acyl-activating enzyme (AAE) consensus motif; other site 246197009583 AMP binding site [chemical binding]; other site 246197009584 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197009585 Condensation domain; Region: Condensation; pfam00668 246197009586 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197009587 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 246197009588 Condensation domain; Region: Condensation; pfam00668 246197009589 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197009590 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197009591 Condensation domain; Region: Condensation; pfam00668 246197009592 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197009593 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197009594 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246197009595 acyl-activating enzyme (AAE) consensus motif; other site 246197009596 AMP binding site [chemical binding]; other site 246197009597 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197009598 Condensation domain; Region: Condensation; pfam00668 246197009599 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197009600 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197009601 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 246197009602 acyl-activating enzyme (AAE) consensus motif; other site 246197009603 AMP binding site [chemical binding]; other site 246197009604 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197009605 Condensation domain; Region: Condensation; pfam00668 246197009606 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197009607 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197009608 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246197009609 acyl-activating enzyme (AAE) consensus motif; other site 246197009610 AMP binding site [chemical binding]; other site 246197009611 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197009612 Condensation domain; Region: Condensation; pfam00668 246197009613 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197009614 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197009615 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 246197009616 acyl-activating enzyme (AAE) consensus motif; other site 246197009617 AMP binding site [chemical binding]; other site 246197009618 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197009619 Condensation domain; Region: Condensation; pfam00668 246197009620 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197009621 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197009622 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246197009623 acyl-activating enzyme (AAE) consensus motif; other site 246197009624 AMP binding site [chemical binding]; other site 246197009625 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197009626 Condensation domain; Region: Condensation; pfam00668 246197009627 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197009628 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197009629 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 246197009630 acyl-activating enzyme (AAE) consensus motif; other site 246197009631 AMP binding site [chemical binding]; other site 246197009632 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197009633 Condensation domain; Region: Condensation; pfam00668 246197009634 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197009635 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197009636 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 246197009637 acyl-activating enzyme (AAE) consensus motif; other site 246197009638 AMP binding site [chemical binding]; other site 246197009639 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197009640 Condensation domain; Region: Condensation; pfam00668 246197009641 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197009642 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197009643 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 246197009644 acyl-activating enzyme (AAE) consensus motif; other site 246197009645 AMP binding site [chemical binding]; other site 246197009646 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197009647 Condensation domain; Region: Condensation; pfam00668 246197009648 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197009649 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197009650 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 246197009651 acyl-activating enzyme (AAE) consensus motif; other site 246197009652 AMP binding site [chemical binding]; other site 246197009653 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197009654 Condensation domain; Region: Condensation; pfam00668 246197009655 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197009656 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197009657 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 246197009658 acyl-activating enzyme (AAE) consensus motif; other site 246197009659 AMP binding site [chemical binding]; other site 246197009660 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197009661 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 246197009662 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197009663 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 246197009664 acyl-activating enzyme (AAE) consensus motif; other site 246197009665 AMP binding site [chemical binding]; other site 246197009666 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197009667 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246197009668 active site 246197009669 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 246197009670 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 246197009671 FAD binding pocket [chemical binding]; other site 246197009672 FAD binding motif [chemical binding]; other site 246197009673 phosphate binding motif [ion binding]; other site 246197009674 NAD binding pocket [chemical binding]; other site 246197009675 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 246197009676 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 246197009677 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246197009678 catalytic residue [active] 246197009679 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246197009680 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246197009681 putative substrate translocation pore; other site 246197009682 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 246197009683 Condensation domain; Region: Condensation; pfam00668 246197009684 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246197009685 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 246197009686 acyl-activating enzyme (AAE) consensus motif; other site 246197009687 AMP binding site [chemical binding]; other site 246197009688 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197009689 thioester reductase domain; Region: Thioester-redct; TIGR01746 246197009690 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 246197009691 putative NAD(P) binding site [chemical binding]; other site 246197009692 active site 246197009693 putative substrate binding site [chemical binding]; other site 246197009694 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 246197009695 Isochorismatase family; Region: Isochorismatase; pfam00857 246197009696 catalytic triad [active] 246197009697 conserved cis-peptide bond; other site 246197009698 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 246197009699 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 246197009700 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 246197009701 acyl-activating enzyme (AAE) consensus motif; other site 246197009702 active site 246197009703 AMP binding site [chemical binding]; other site 246197009704 substrate binding site [chemical binding]; other site 246197009705 isochorismate synthase DhbC; Validated; Region: PRK06923 246197009706 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 246197009707 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase; Region: dhbA_paeA; TIGR04316 246197009708 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246197009709 NAD(P) binding site [chemical binding]; other site 246197009710 active site 246197009711 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 246197009712 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 246197009713 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 246197009714 sensory histidine kinase CreC; Provisional; Region: PRK11100 246197009715 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 246197009716 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 246197009717 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 246197009718 FtsX-like permease family; Region: FtsX; pfam02687 246197009719 Protein of unknown function (DUF421); Region: DUF421; pfam04239 246197009720 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 3. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_3; cd03328 246197009721 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 246197009722 putative active site pocket [active] 246197009723 putative metal binding site [ion binding]; other site 246197009724 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 246197009725 FAD binding domain; Region: FAD_binding_4; pfam01565 246197009726 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 246197009727 Cysteine-rich domain; Region: CCG; pfam02754 246197009728 thiamine pyrophosphate protein; Provisional; Region: PRK08273 246197009729 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 246197009730 PYR/PP interface [polypeptide binding]; other site 246197009731 dimer interface [polypeptide binding]; other site 246197009732 tetramer interface [polypeptide binding]; other site 246197009733 TPP binding site [chemical binding]; other site 246197009734 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 246197009735 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 246197009736 TPP-binding site [chemical binding]; other site 246197009737 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 246197009738 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 246197009739 Domain of unknown function (DUF4082); Region: DUF4082; pfam13313 246197009740 HTH domain; Region: HTH_11; pfam08279 246197009741 WYL domain; Region: WYL; pfam13280 246197009742 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 246197009743 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 246197009744 active site 246197009745 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 246197009746 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 246197009747 Protein of unknown function (DUF3565); Region: DUF3565; pfam12088 246197009748 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 246197009749 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 246197009750 Uncharacterized conserved protein [Function unknown]; Region: COG1262 246197009751 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 246197009752 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 246197009753 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 246197009754 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 246197009755 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246197009756 dimerization interface [polypeptide binding]; other site 246197009757 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 246197009758 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 246197009759 dimer interface [polypeptide binding]; other site 246197009760 putative CheW interface [polypeptide binding]; other site 246197009761 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 246197009762 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 246197009763 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 246197009764 HlyD family secretion protein; Region: HlyD_3; pfam13437 246197009765 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 246197009766 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 246197009767 catalytic residues [active] 246197009768 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 246197009769 Fungalysin metallopeptidase (M36); Region: Peptidase_M36; pfam02128 246197009770 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 246197009771 Zn binding site [ion binding]; other site 246197009772 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 246197009773 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 246197009774 substrate binding pocket [chemical binding]; other site 246197009775 chain length determination region; other site 246197009776 substrate-Mg2+ binding site; other site 246197009777 catalytic residues [active] 246197009778 aspartate-rich region 1; other site 246197009779 active site lid residues [active] 246197009780 aspartate-rich region 2; other site 246197009781 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246197009782 dimerization interface [polypeptide binding]; other site 246197009783 putative Zn2+ binding site [ion binding]; other site 246197009784 putative DNA binding site [nucleotide binding]; other site 246197009785 dimerization interface [polypeptide binding]; other site 246197009786 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 246197009787 putative catalytic residue [active] 246197009788 glycogen branching enzyme; Provisional; Region: PRK05402 246197009789 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 246197009790 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 246197009791 active site 246197009792 catalytic site [active] 246197009793 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 246197009794 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 246197009795 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 246197009796 trehalose synthase; Region: treS_nterm; TIGR02456 246197009797 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 246197009798 active site 246197009799 catalytic site [active] 246197009800 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 246197009801 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 246197009802 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 246197009803 active site 246197009804 homodimer interface [polypeptide binding]; other site 246197009805 catalytic site [active] 246197009806 acceptor binding site [chemical binding]; other site 246197009807 RNA polymerase sigma factor; Provisional; Region: PRK12519 246197009808 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246197009809 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246197009810 DNA binding residues [nucleotide binding] 246197009811 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 246197009812 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 246197009813 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 246197009814 Domain of unknown function (DUF4382); Region: DUF4382; pfam14321 246197009815 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246197009816 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 246197009817 phosphopeptide binding site; other site 246197009818 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197009819 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 246197009820 Walker A motif; other site 246197009821 ATP binding site [chemical binding]; other site 246197009822 Walker B motif; other site 246197009823 arginine finger; other site 246197009824 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 246197009825 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 246197009826 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197009827 active site 246197009828 ATP binding site [chemical binding]; other site 246197009829 substrate binding site [chemical binding]; other site 246197009830 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246197009831 substrate binding site [chemical binding]; other site 246197009832 activation loop (A-loop); other site 246197009833 activation loop (A-loop); other site 246197009834 Tetratricopeptide repeat; Region: TPR_16; pfam13432 246197009835 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197009836 TPR motif; other site 246197009837 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 246197009838 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 246197009839 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 246197009840 active site 246197009841 catalytic site [active] 246197009842 Cyclo-malto-dextrinase C-terminal domain; Region: Cyc-maltodext_C; pfam10438 246197009843 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 246197009844 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 246197009845 active site 246197009846 PHP-associated; Region: PHP_C; pfam13263 246197009847 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 246197009848 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 246197009849 metal binding site 2 [ion binding]; metal-binding site 246197009850 putative DNA binding helix; other site 246197009851 metal binding site 1 [ion binding]; metal-binding site 246197009852 dimer interface [polypeptide binding]; other site 246197009853 structural Zn2+ binding site [ion binding]; other site 246197009854 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 246197009855 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 246197009856 catalytic residues [active] 246197009857 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 246197009858 Septum formation initiator; Region: DivIC; pfam04977 246197009859 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 246197009860 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 246197009861 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 246197009862 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 246197009863 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 246197009864 metal binding site [ion binding]; metal-binding site 246197009865 active site 246197009866 I-site; other site 246197009867 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 246197009868 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 246197009869 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 246197009870 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197009871 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 246197009872 putative active site [active] 246197009873 5' nucleotidase family; Region: 5_nucleotid; pfam05761 246197009874 Protein kinase domain; Region: Pkinase; pfam00069 246197009875 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197009876 active site 246197009877 ATP binding site [chemical binding]; other site 246197009878 substrate binding site [chemical binding]; other site 246197009879 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246197009880 substrate binding site [chemical binding]; other site 246197009881 activation loop (A-loop); other site 246197009882 activation loop (A-loop); other site 246197009883 PEGA domain; Region: PEGA; pfam08308 246197009884 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246197009885 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197009886 active site 246197009887 phosphorylation site [posttranslational modification] 246197009888 intermolecular recognition site; other site 246197009889 dimerization interface [polypeptide binding]; other site 246197009890 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246197009891 DNA binding residues [nucleotide binding] 246197009892 dimerization interface [polypeptide binding]; other site 246197009893 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 246197009894 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 246197009895 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 246197009896 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 246197009897 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 246197009898 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 246197009899 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 246197009900 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 246197009901 active site 246197009902 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 246197009903 Permease; Region: Permease; pfam02405 246197009904 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 246197009905 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 246197009906 Walker A/P-loop; other site 246197009907 ATP binding site [chemical binding]; other site 246197009908 Q-loop/lid; other site 246197009909 ABC transporter signature motif; other site 246197009910 Walker B; other site 246197009911 D-loop; other site 246197009912 H-loop/switch region; other site 246197009913 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 246197009914 mce related protein; Region: MCE; pfam02470 246197009915 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 246197009916 substrate binding site [chemical binding]; other site 246197009917 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 246197009918 ATP binding site [chemical binding]; other site 246197009919 Myxococcus xanthus paralogous domain TIGR02266; Region: gmx_TIGR02266 246197009920 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 246197009921 histidyl-tRNA synthetase; Region: hisS; TIGR00442 246197009922 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 246197009923 dimer interface [polypeptide binding]; other site 246197009924 motif 1; other site 246197009925 active site 246197009926 motif 2; other site 246197009927 motif 3; other site 246197009928 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 246197009929 anticodon binding site; other site 246197009930 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 246197009931 Catalytic site [active] 246197009932 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 246197009933 PQQ-like domain; Region: PQQ_2; pfam13360 246197009934 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 246197009935 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 246197009936 Trp docking motif [polypeptide binding]; other site 246197009937 active site 246197009938 HprK-related kinase A; Region: HprK_rel_A; TIGR04352 246197009939 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 246197009940 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 246197009941 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 246197009942 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 246197009943 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197009944 Response regulator receiver domain; Region: Response_reg; pfam00072 246197009945 active site 246197009946 phosphorylation site [posttranslational modification] 246197009947 intermolecular recognition site; other site 246197009948 dimerization interface [polypeptide binding]; other site 246197009949 Response regulator receiver domain; Region: Response_reg; pfam00072 246197009950 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197009951 active site 246197009952 phosphorylation site [posttranslational modification] 246197009953 intermolecular recognition site; other site 246197009954 dimerization interface [polypeptide binding]; other site 246197009955 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 246197009956 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 246197009957 metal binding site [ion binding]; metal-binding site 246197009958 active site 246197009959 I-site; other site 246197009960 Tetratricopeptide repeat; Region: TPR_16; pfam13432 246197009961 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197009962 TPR motif; other site 246197009963 binding surface 246197009964 Response regulator receiver domain; Region: Response_reg; pfam00072 246197009965 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197009966 active site 246197009967 phosphorylation site [posttranslational modification] 246197009968 intermolecular recognition site; other site 246197009969 dimerization interface [polypeptide binding]; other site 246197009970 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 246197009971 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 246197009972 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 246197009973 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 246197009974 putative active site; other site 246197009975 catalytic residue [active] 246197009976 Outer membrane efflux protein; Region: OEP; pfam02321 246197009977 Outer membrane efflux protein; Region: OEP; pfam02321 246197009978 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 246197009979 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 246197009980 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246197009981 NAD(P) binding site [chemical binding]; other site 246197009982 active site 246197009983 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 246197009984 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 246197009985 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246197009986 catalytic residue [active] 246197009987 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 246197009988 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 246197009989 active site 246197009990 aminotransferase; Validated; Region: PRK07777 246197009991 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246197009992 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246197009993 homodimer interface [polypeptide binding]; other site 246197009994 catalytic residue [active] 246197009995 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197009996 S-adenosylmethionine binding site [chemical binding]; other site 246197009997 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 246197009998 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 246197009999 active site 246197010000 catalytic residues [active] 246197010001 metal binding site [ion binding]; metal-binding site 246197010002 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 246197010003 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 246197010004 dimer interface [polypeptide binding]; other site 246197010005 putative CheW interface [polypeptide binding]; other site 246197010006 Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane; Region: Tim44; smart00978 246197010007 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 246197010008 Double zinc ribbon; Region: DZR; pfam12773 246197010009 tellurium resistance terB-like protein; Region: terB_like; cd07177 246197010010 metal binding site [ion binding]; metal-binding site 246197010011 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246197010012 enoyl-CoA hydratase; Provisional; Region: PRK07657 246197010013 substrate binding site [chemical binding]; other site 246197010014 oxyanion hole (OAH) forming residues; other site 246197010015 trimer interface [polypeptide binding]; other site 246197010016 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 246197010017 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 246197010018 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 246197010019 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246197010020 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246197010021 active site 246197010022 ribonuclease III; Reviewed; Region: rnc; PRK00102 246197010023 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 246197010024 dimerization interface [polypeptide binding]; other site 246197010025 active site 246197010026 metal binding site [ion binding]; metal-binding site 246197010027 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 246197010028 dsRNA binding site [nucleotide binding]; other site 246197010029 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 246197010030 active site 246197010031 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 246197010032 active site 246197010033 GTPase Era; Reviewed; Region: era; PRK00089 246197010034 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 246197010035 G1 box; other site 246197010036 GTP/Mg2+ binding site [chemical binding]; other site 246197010037 Switch I region; other site 246197010038 G2 box; other site 246197010039 Switch II region; other site 246197010040 G3 box; other site 246197010041 G4 box; other site 246197010042 G5 box; other site 246197010043 KH domain; Region: KH_2; pfam07650 246197010044 GTP-binding protein Der; Reviewed; Region: PRK00093 246197010045 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 246197010046 G1 box; other site 246197010047 GTP/Mg2+ binding site [chemical binding]; other site 246197010048 Switch I region; other site 246197010049 G2 box; other site 246197010050 Switch II region; other site 246197010051 G3 box; other site 246197010052 G4 box; other site 246197010053 G5 box; other site 246197010054 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 246197010055 G1 box; other site 246197010056 GTP/Mg2+ binding site [chemical binding]; other site 246197010057 Switch I region; other site 246197010058 G2 box; other site 246197010059 G3 box; other site 246197010060 Switch II region; other site 246197010061 G4 box; other site 246197010062 G5 box; other site 246197010063 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197010064 binding surface 246197010065 TPR motif; other site 246197010066 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 246197010067 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 246197010068 Trp docking motif [polypeptide binding]; other site 246197010069 PQQ-like domain; Region: PQQ_2; pfam13360 246197010070 active site 246197010071 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 246197010072 active site 246197010073 8-oxo-dGMP binding site [chemical binding]; other site 246197010074 nudix motif; other site 246197010075 metal binding site [ion binding]; metal-binding site 246197010076 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 246197010077 RNase_H superfamily; Region: RNase_H_2; pfam13482 246197010078 Protein of unknown function (DUF3014); Region: DUF3014; pfam11219 246197010079 histidinol-phosphatase; Validated; Region: PRK06740 246197010080 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 246197010081 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 246197010082 FtsX-like permease family; Region: FtsX; pfam02687 246197010083 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 246197010084 FtsX-like permease family; Region: FtsX; pfam02687 246197010085 Peptidase S46; Region: Peptidase_S46; pfam10459 246197010086 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 246197010087 GMP synthase; Reviewed; Region: guaA; PRK00074 246197010088 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 246197010089 AMP/PPi binding site [chemical binding]; other site 246197010090 candidate oxyanion hole; other site 246197010091 catalytic triad [active] 246197010092 potential glutamine specificity residues [chemical binding]; other site 246197010093 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 246197010094 ATP Binding subdomain [chemical binding]; other site 246197010095 Ligand Binding sites [chemical binding]; other site 246197010096 Dimerization subdomain; other site 246197010097 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 246197010098 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 246197010099 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 246197010100 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 246197010101 active site 246197010102 Myxococcus xanthus paralogous domain TIGR02266; Region: gmx_TIGR02266 246197010103 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 246197010104 nucleotide binding site [chemical binding]; other site 246197010105 acyl-CoA synthetase; Validated; Region: PRK05850 246197010106 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 246197010107 acyl-activating enzyme (AAE) consensus motif; other site 246197010108 active site 246197010109 Condensation domain; Region: Condensation; pfam00668 246197010110 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197010111 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197010112 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246197010113 acyl-activating enzyme (AAE) consensus motif; other site 246197010114 AMP binding site [chemical binding]; other site 246197010115 Methyltransferase domain; Region: Methyltransf_31; pfam13847 246197010116 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197010117 S-adenosylmethionine binding site [chemical binding]; other site 246197010118 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246197010119 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197010120 Condensation domain; Region: Condensation; pfam00668 246197010121 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197010122 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197010123 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 246197010124 acyl-activating enzyme (AAE) consensus motif; other site 246197010125 AMP binding site [chemical binding]; other site 246197010126 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197010127 Condensation domain; Region: Condensation; pfam00668 246197010128 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197010129 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197010130 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 246197010131 acyl-activating enzyme (AAE) consensus motif; other site 246197010132 AMP binding site [chemical binding]; other site 246197010133 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197010134 Condensation domain; Region: Condensation; pfam00668 246197010135 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197010136 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197010137 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246197010138 acyl-activating enzyme (AAE) consensus motif; other site 246197010139 AMP binding site [chemical binding]; other site 246197010140 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197010141 Condensation domain; Region: Condensation; pfam00668 246197010142 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197010143 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197010144 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246197010145 acyl-activating enzyme (AAE) consensus motif; other site 246197010146 AMP binding site [chemical binding]; other site 246197010147 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197010148 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 246197010149 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246197010150 active site 246197010151 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 246197010152 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 246197010153 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197010154 Condensation domain; Region: Condensation; pfam00668 246197010155 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197010156 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197010157 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 246197010158 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 246197010159 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246197010160 Condensation domain; Region: Condensation; pfam00668 246197010161 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197010162 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197010163 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246197010164 acyl-activating enzyme (AAE) consensus motif; other site 246197010165 AMP binding site [chemical binding]; other site 246197010166 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197010167 Condensation domain; Region: Condensation; pfam00668 246197010168 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197010169 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197010170 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246197010171 acyl-activating enzyme (AAE) consensus motif; other site 246197010172 AMP binding site [chemical binding]; other site 246197010173 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197010174 Condensation domain; Region: Condensation; pfam00668 246197010175 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197010176 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197010177 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246197010178 acyl-activating enzyme (AAE) consensus motif; other site 246197010179 AMP binding site [chemical binding]; other site 246197010180 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197010181 Condensation domain; Region: Condensation; pfam00668 246197010182 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197010183 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197010184 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246197010185 acyl-activating enzyme (AAE) consensus motif; other site 246197010186 AMP binding site [chemical binding]; other site 246197010187 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197010188 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 246197010189 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197010190 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246197010191 acyl-activating enzyme (AAE) consensus motif; other site 246197010192 AMP binding site [chemical binding]; other site 246197010193 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197010194 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 246197010195 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 246197010196 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 246197010197 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 246197010198 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 246197010199 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 246197010200 ligand binding site [chemical binding]; other site 246197010201 flexible hinge region; other site 246197010202 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 246197010203 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 246197010204 trimer interface [polypeptide binding]; other site 246197010205 putative metal binding site [ion binding]; other site 246197010206 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 246197010207 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 246197010208 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246197010209 FeS/SAM binding site; other site 246197010210 TRAM domain; Region: TRAM; pfam01938 246197010211 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 246197010212 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 246197010213 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 246197010214 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197010215 S-adenosylmethionine binding site [chemical binding]; other site 246197010216 Myxococcus xanthus paralogous domain TIGR02266; Region: gmx_TIGR02266 246197010217 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 246197010218 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 246197010219 putative acyltransferase; Provisional; Region: PRK05790 246197010220 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 246197010221 dimer interface [polypeptide binding]; other site 246197010222 active site 246197010223 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 246197010224 FOG: WD40 repeat [General function prediction only]; Region: COG2319 246197010225 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 246197010226 structural tetrad; other site 246197010227 FOG: WD40 repeat [General function prediction only]; Region: COG2319 246197010228 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 246197010229 structural tetrad; other site 246197010230 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 246197010231 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 246197010232 RNA binding site [nucleotide binding]; other site 246197010233 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 246197010234 RNA binding site [nucleotide binding]; other site 246197010235 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 246197010236 RNA binding site [nucleotide binding]; other site 246197010237 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 246197010238 RNA binding site [nucleotide binding]; other site 246197010239 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 246197010240 RNA binding site [nucleotide binding]; other site 246197010241 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 246197010242 RNA binding site [nucleotide binding]; other site 246197010243 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246197010244 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246197010245 active site 246197010246 Gram-negative bacterial tonB protein; Region: TonB; cl10048 246197010247 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246197010248 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 246197010249 FAD binding site [chemical binding]; other site 246197010250 homotetramer interface [polypeptide binding]; other site 246197010251 substrate binding pocket [chemical binding]; other site 246197010252 catalytic base [active] 246197010253 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 246197010254 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246197010255 substrate binding site [chemical binding]; other site 246197010256 oxyanion hole (OAH) forming residues; other site 246197010257 trimer interface [polypeptide binding]; other site 246197010258 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 246197010259 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 246197010260 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 246197010261 antiporter inner membrane protein; Provisional; Region: PRK11670 246197010262 Domain of unknown function DUF59; Region: DUF59; pfam01883 246197010263 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 246197010264 Walker A motif; other site 246197010265 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 246197010266 Winged helix-turn helix; Region: HTH_29; pfam13551 246197010267 DDE superfamily endonuclease; Region: DDE_3; pfam13358 246197010268 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 246197010269 Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982 246197010270 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 246197010271 tandem repeat interface [polypeptide binding]; other site 246197010272 oligomer interface [polypeptide binding]; other site 246197010273 active site residues [active] 246197010274 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 246197010275 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 246197010276 tandem repeat interface [polypeptide binding]; other site 246197010277 oligomer interface [polypeptide binding]; other site 246197010278 active site residues [active] 246197010279 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 246197010280 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 246197010281 putative active site [active] 246197010282 Predicted acyl esterases [General function prediction only]; Region: COG2936 246197010283 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 246197010284 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 246197010285 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 246197010286 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197010287 active site 246197010288 phosphorylation site [posttranslational modification] 246197010289 intermolecular recognition site; other site 246197010290 dimerization interface [polypeptide binding]; other site 246197010291 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197010292 Walker A motif; other site 246197010293 ATP binding site [chemical binding]; other site 246197010294 Walker B motif; other site 246197010295 arginine finger; other site 246197010296 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 246197010297 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197010298 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197010299 dimer interface [polypeptide binding]; other site 246197010300 phosphorylation site [posttranslational modification] 246197010301 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197010302 ATP binding site [chemical binding]; other site 246197010303 Mg2+ binding site [ion binding]; other site 246197010304 G-X-G motif; other site 246197010305 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 246197010306 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 246197010307 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246197010308 putative substrate translocation pore; other site 246197010309 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 246197010310 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 246197010311 Myxococcales-restricted protein, TIGR02265 family; Region: Mxa_TIGR02265 246197010312 Poly(3-hydroxyalkanoate) synthetase [Lipid metabolism]; Region: PhaC; COG3243 246197010313 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 246197010314 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 246197010315 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 246197010316 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 246197010317 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 246197010318 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 246197010319 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 246197010320 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 246197010321 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 246197010322 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 246197010323 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 246197010324 catalytic triad [active] 246197010325 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 246197010326 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 246197010327 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 246197010328 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 246197010329 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 246197010330 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 246197010331 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 246197010332 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 246197010333 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 246197010334 active site 246197010335 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 246197010336 catalytic triad [active] 246197010337 dimer interface [polypeptide binding]; other site 246197010338 bile acid transporter; Region: bass; TIGR00841 246197010339 Sodium Bile acid symporter family; Region: SBF; cl17470 246197010340 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 246197010341 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 246197010342 RNase_H superfamily; Region: RNase_H_2; pfam13482 246197010343 active site 246197010344 substrate binding site [chemical binding]; other site 246197010345 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 246197010346 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246197010347 ATP binding site [chemical binding]; other site 246197010348 putative Mg++ binding site [ion binding]; other site 246197010349 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246197010350 nucleotide binding region [chemical binding]; other site 246197010351 ATP-binding site [chemical binding]; other site 246197010352 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 246197010353 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 246197010354 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 246197010355 transmembrane helices; other site 246197010356 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 246197010357 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197010358 binding surface 246197010359 TPR repeat; Region: TPR_11; pfam13414 246197010360 TPR motif; other site 246197010361 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 246197010362 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 246197010363 ligand binding site [chemical binding]; other site 246197010364 flexible hinge region; other site 246197010365 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 246197010366 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 246197010367 ligand binding site [chemical binding]; other site 246197010368 flexible hinge region; other site 246197010369 HEAT repeats; Region: HEAT_2; pfam13646 246197010370 HEAT repeats; Region: HEAT_2; pfam13646 246197010371 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 246197010372 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 246197010373 RNA binding surface [nucleotide binding]; other site 246197010374 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 246197010375 active site 246197010376 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 246197010377 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 246197010378 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 246197010379 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 246197010380 active site 246197010381 HIGH motif; other site 246197010382 dimer interface [polypeptide binding]; other site 246197010383 KMSKS motif; other site 246197010384 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 246197010385 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 246197010386 active site 246197010387 Int/Topo IB signature motif; other site 246197010388 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 246197010389 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 246197010390 Small hydrophilic plant seed protein; Region: LEA_5; pfam00477 246197010391 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 246197010392 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 246197010393 active site 246197010394 nucleophile elbow; other site 246197010395 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 246197010396 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 246197010397 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 246197010398 active site 246197010399 Fatty acid desaturase; Region: FA_desaturase; pfam00487 246197010400 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 246197010401 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 246197010402 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 246197010403 iron-sulfur cluster [ion binding]; other site 246197010404 [2Fe-2S] cluster binding site [ion binding]; other site 246197010405 thiamine pyrophosphate protein; Provisional; Region: PRK08273 246197010406 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 246197010407 PYR/PP interface [polypeptide binding]; other site 246197010408 dimer interface [polypeptide binding]; other site 246197010409 tetramer interface [polypeptide binding]; other site 246197010410 TPP binding site [chemical binding]; other site 246197010411 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 246197010412 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 246197010413 TPP-binding site [chemical binding]; other site 246197010414 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 246197010415 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663 246197010416 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 246197010417 Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899 246197010418 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599 246197010419 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 246197010420 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 246197010421 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 246197010422 Subunit I/III interface [polypeptide binding]; other site 246197010423 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 246197010424 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 246197010425 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 246197010426 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 246197010427 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 246197010428 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 246197010429 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 246197010430 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 246197010431 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 246197010432 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 246197010433 molybdopterin cofactor binding site; other site 246197010434 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 246197010435 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 246197010436 4Fe-4S binding domain; Region: Fer4; cl02805 246197010437 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 246197010438 heme-binding residues [chemical binding]; other site 246197010439 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 246197010440 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 246197010441 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 246197010442 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 246197010443 PAS fold; Region: PAS_4; pfam08448 246197010444 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246197010445 putative active site [active] 246197010446 heme pocket [chemical binding]; other site 246197010447 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 246197010448 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197010449 dimer interface [polypeptide binding]; other site 246197010450 phosphorylation site [posttranslational modification] 246197010451 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197010452 ATP binding site [chemical binding]; other site 246197010453 Mg2+ binding site [ion binding]; other site 246197010454 G-X-G motif; other site 246197010455 Response regulator receiver domain; Region: Response_reg; pfam00072 246197010456 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197010457 active site 246197010458 phosphorylation site [posttranslational modification] 246197010459 intermolecular recognition site; other site 246197010460 dimerization interface [polypeptide binding]; other site 246197010461 Response regulator receiver domain; Region: Response_reg; pfam00072 246197010462 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197010463 active site 246197010464 phosphorylation site [posttranslational modification] 246197010465 intermolecular recognition site; other site 246197010466 dimerization interface [polypeptide binding]; other site 246197010467 benzoate transport; Region: 2A0115; TIGR00895 246197010468 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246197010469 putative substrate translocation pore; other site 246197010470 pyruvate carboxylase; Reviewed; Region: PRK12999 246197010471 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 246197010472 ATP-grasp domain; Region: ATP-grasp_4; cl17255 246197010473 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 246197010474 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 246197010475 active site 246197010476 catalytic residues [active] 246197010477 metal binding site [ion binding]; metal-binding site 246197010478 homodimer binding site [polypeptide binding]; other site 246197010479 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 246197010480 carboxyltransferase (CT) interaction site; other site 246197010481 biotinylation site [posttranslational modification]; other site 246197010482 Spore Coat Protein U domain; Region: SCPU; pfam05229 246197010483 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 246197010484 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 246197010485 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 246197010486 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 246197010487 Spore Coat Protein U domain; Region: SCPU; pfam05229 246197010488 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 246197010489 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 246197010490 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 246197010491 active site 246197010492 metal binding site [ion binding]; metal-binding site 246197010493 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 246197010494 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 246197010495 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 246197010496 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246197010497 catalytic residue [active] 246197010498 maltose O-acetyltransferase; Provisional; Region: PRK10092 246197010499 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 246197010500 active site 246197010501 substrate binding site [chemical binding]; other site 246197010502 trimer interface [polypeptide binding]; other site 246197010503 CoA binding site [chemical binding]; other site 246197010504 Protein of unknown function (DUF998); Region: DUF998; pfam06197 246197010505 acyl carrier protein; Provisional; Region: acpP; PRK00982 246197010506 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 246197010507 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246197010508 active site 246197010509 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 246197010510 MutS domain I; Region: MutS_I; pfam01624 246197010511 MutS domain II; Region: MutS_II; pfam05188 246197010512 MutS domain III; Region: MutS_III; pfam05192 246197010513 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 246197010514 Walker A/P-loop; other site 246197010515 ATP binding site [chemical binding]; other site 246197010516 Q-loop/lid; other site 246197010517 ABC transporter signature motif; other site 246197010518 Walker B; other site 246197010519 D-loop; other site 246197010520 H-loop/switch region; other site 246197010521 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560 246197010522 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 246197010523 ABC1 family; Region: ABC1; cl17513 246197010524 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 246197010525 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 246197010526 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 246197010527 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 246197010528 HlyD family secretion protein; Region: HlyD_3; pfam13437 246197010529 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 246197010530 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 246197010531 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 246197010532 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 246197010533 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 246197010534 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246197010535 Walker A/P-loop; other site 246197010536 ATP binding site [chemical binding]; other site 246197010537 Q-loop/lid; other site 246197010538 ABC transporter signature motif; other site 246197010539 Walker B; other site 246197010540 D-loop; other site 246197010541 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 246197010542 Permease; Region: Permease; pfam02405 246197010543 Permease; Region: Permease; pfam02405 246197010544 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 246197010545 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246197010546 Walker A/P-loop; other site 246197010547 ATP binding site [chemical binding]; other site 246197010548 Q-loop/lid; other site 246197010549 ABC transporter signature motif; other site 246197010550 Walker B; other site 246197010551 D-loop; other site 246197010552 H-loop/switch region; other site 246197010553 mce related protein; Region: MCE; pfam02470 246197010554 T-complex protein 11; Region: Tcp11; pfam05794 246197010555 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 246197010556 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 246197010557 ATP binding site [chemical binding]; other site 246197010558 putative Mg++ binding site [ion binding]; other site 246197010559 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246197010560 nucleotide binding region [chemical binding]; other site 246197010561 ATP-binding site [chemical binding]; other site 246197010562 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 246197010563 RNA binding site [nucleotide binding]; other site 246197010564 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 246197010565 PepSY-associated TM helix; Region: PepSY_TM_3; pfam13706 246197010566 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 246197010567 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 246197010568 putative active site [active] 246197010569 nucleotide binding site [chemical binding]; other site 246197010570 nudix motif; other site 246197010571 putative metal binding site [ion binding]; other site 246197010572 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 246197010573 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 246197010574 active site 246197010575 dimer interface [polypeptide binding]; other site 246197010576 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 246197010577 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 246197010578 active site 246197010579 FMN binding site [chemical binding]; other site 246197010580 substrate binding site [chemical binding]; other site 246197010581 3Fe-4S cluster binding site [ion binding]; other site 246197010582 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 246197010583 domain interface; other site 246197010584 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 246197010585 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 246197010586 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 246197010587 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 246197010588 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 246197010589 P-loop; other site 246197010590 Magnesium ion binding site [ion binding]; other site 246197010591 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 246197010592 Magnesium ion binding site [ion binding]; other site 246197010593 Cytochrome c; Region: Cytochrom_C; cl11414 246197010594 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 246197010595 HlyD family secretion protein; Region: HlyD_3; pfam13437 246197010596 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 246197010597 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 246197010598 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 246197010599 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 246197010600 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 246197010601 nudix motif; other site 246197010602 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246197010603 Radical SAM superfamily; Region: Radical_SAM; pfam04055 246197010604 FeS/SAM binding site; other site 246197010605 DTW domain; Region: DTW; cl01221 246197010606 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 246197010607 Methyltransferase domain; Region: Methyltransf_31; pfam13847 246197010608 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197010609 S-adenosylmethionine binding site [chemical binding]; other site 246197010610 Putative methyltransferase; Region: Methyltransf_4; cl17290 246197010611 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197010612 S-adenosylmethionine binding site [chemical binding]; other site 246197010613 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 246197010614 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 246197010615 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246197010616 active site 246197010617 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 246197010618 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 246197010619 putative NADP binding site [chemical binding]; other site 246197010620 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 246197010621 active site 246197010622 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 246197010623 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197010624 S-adenosylmethionine binding site [chemical binding]; other site 246197010625 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 246197010626 polyketide synthase; Region: polyketide_synthase; cd08251 246197010627 Enoylreductase; Region: PKS_ER; smart00829 246197010628 putative NAD(P) binding site [chemical binding]; other site 246197010629 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 246197010630 polyketide synthase; Region: polyketide_synthase; cd08251 246197010631 Enoylreductase; Region: PKS_ER; smart00829 246197010632 putative NAD(P) binding site [chemical binding]; other site 246197010633 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246197010634 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 246197010635 active site 246197010636 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 246197010637 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 246197010638 KR domain; Region: KR; pfam08659 246197010639 putative NADP binding site [chemical binding]; other site 246197010640 active site 246197010641 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197010642 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 246197010643 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246197010644 active site 246197010645 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 246197010646 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 246197010647 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 246197010648 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246197010649 active site 246197010650 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 246197010651 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 246197010652 putative NADP binding site [chemical binding]; other site 246197010653 KR domain; Region: KR; pfam08659 246197010654 active site 246197010655 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 246197010656 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246197010657 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 246197010658 active site 246197010659 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 246197010660 FMN binding site [chemical binding]; other site 246197010661 substrate binding site [chemical binding]; other site 246197010662 putative catalytic residue [active] 246197010663 Condensation domain; Region: Condensation; pfam00668 246197010664 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197010665 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197010666 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 246197010667 acyl-activating enzyme (AAE) consensus motif; other site 246197010668 AMP binding site [chemical binding]; other site 246197010669 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197010670 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 246197010671 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246197010672 active site 246197010673 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 246197010674 KR domain; Region: KR; pfam08659 246197010675 putative NADP binding site [chemical binding]; other site 246197010676 active site 246197010677 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197010678 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246197010679 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 246197010680 active site 246197010681 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 246197010682 putative NADP binding site [chemical binding]; other site 246197010683 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 246197010684 active site 246197010685 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197010686 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246197010687 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 246197010688 active site 246197010689 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197010690 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 246197010691 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246197010692 active site 246197010693 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 246197010694 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 246197010695 putative NADP binding site [chemical binding]; other site 246197010696 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 246197010697 active site 246197010698 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197010699 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246197010700 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 246197010701 active site 246197010702 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 246197010703 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246197010704 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 246197010705 active site 246197010706 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 246197010707 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 246197010708 putative NADP binding site [chemical binding]; other site 246197010709 KR domain; Region: KR; pfam08659 246197010710 active site 246197010711 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197010712 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246197010713 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 246197010714 active site 246197010715 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 246197010716 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 246197010717 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246197010718 active site 246197010719 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 246197010720 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246197010721 NAD(P) binding site [chemical binding]; other site 246197010722 KR domain; Region: KR; pfam08659 246197010723 active site 246197010724 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197010725 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246197010726 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 246197010727 active site 246197010728 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197010729 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 246197010730 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 246197010731 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197010732 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246197010733 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 246197010734 active site 246197010735 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 246197010736 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 246197010737 putative NADP binding site [chemical binding]; other site 246197010738 active site 246197010739 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197010740 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246197010741 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 246197010742 substrate binding site [chemical binding]; other site 246197010743 oxyanion hole (OAH) forming residues; other site 246197010744 trimer interface [polypeptide binding]; other site 246197010745 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246197010746 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 246197010747 substrate binding site [chemical binding]; other site 246197010748 oxyanion hole (OAH) forming residues; other site 246197010749 trimer interface [polypeptide binding]; other site 246197010750 polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103 246197010751 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 246197010752 dimer interface [polypeptide binding]; other site 246197010753 active site 246197010754 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 246197010755 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 246197010756 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 246197010757 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 246197010758 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246197010759 Cytochrome P450; Region: p450; cl12078 246197010760 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 246197010761 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 246197010762 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 246197010763 dimer interface [polypeptide binding]; other site 246197010764 active site 246197010765 acyl carrier protein; Validated; Region: PRK07117 246197010766 biosynthesis cluster domain; Region: biosyn_clust_1; TIGR04098 246197010767 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 246197010768 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 246197010769 dimer interface [polypeptide binding]; other site 246197010770 active site 246197010771 acyl carrier protein; Validated; Region: PRK07117 246197010772 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), TaA; Region: NGN_SP_TaA; cd09893 246197010773 transcriptional activator RfaH; Region: RfaH; TIGR01955 246197010774 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 246197010775 heterodimer interface [polypeptide binding]; other site 246197010776 homodimer interface [polypeptide binding]; other site 246197010777 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 246197010778 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 246197010779 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 246197010780 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197010781 Walker A motif; other site 246197010782 ATP binding site [chemical binding]; other site 246197010783 Walker B motif; other site 246197010784 arginine finger; other site 246197010785 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 246197010786 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09701 246197010787 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197010788 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197010789 active site 246197010790 ATP binding site [chemical binding]; other site 246197010791 substrate binding site [chemical binding]; other site 246197010792 activation loop (A-loop); other site 246197010793 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246197010794 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 246197010795 phosphopeptide binding site; other site 246197010796 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 246197010797 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 246197010798 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 246197010799 cyclase homology domain; Region: CHD; cd07302 246197010800 nucleotidyl binding site; other site 246197010801 metal binding site [ion binding]; metal-binding site 246197010802 dimer interface [polypeptide binding]; other site 246197010803 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 246197010804 Uncharacterized conserved protein [Function unknown]; Region: COG0585 246197010805 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 246197010806 active site 246197010807 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 246197010808 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246197010809 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246197010810 DNA binding residues [nucleotide binding] 246197010811 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 246197010812 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 246197010813 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 246197010814 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 246197010815 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 246197010816 classical (c) SDRs; Region: SDR_c; cd05233 246197010817 NAD(P) binding site [chemical binding]; other site 246197010818 active site 246197010819 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246197010820 Ligand Binding Site [chemical binding]; other site 246197010821 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991 246197010822 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 246197010823 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 246197010824 putative acyl-acceptor binding pocket; other site 246197010825 Methanothermobacter thermautotrophicus Mth212-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Mth212-like_AP-endo; cd09085 246197010826 active site 246197010827 putative catalytic site [active] 246197010828 phosphate binding site A [ion binding]; other site 246197010829 DNA binding site [nucleotide binding] 246197010830 metal binding site A [ion binding]; metal-binding site 246197010831 putative AP binding site [nucleotide binding]; other site 246197010832 putative metal binding site B [ion binding]; other site 246197010833 phosphate binding site B [ion binding]; other site 246197010834 Lamin Tail Domain; Region: LTD; pfam00932 246197010835 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246197010836 TAP-like protein; Region: Abhydrolase_4; pfam08386 246197010837 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 246197010838 GAF domain; Region: GAF; pfam01590 246197010839 GAF domain; Region: GAF_2; pfam13185 246197010840 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 246197010841 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197010842 phosphorylation site [posttranslational modification] 246197010843 dimer interface [polypeptide binding]; other site 246197010844 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197010845 ATP binding site [chemical binding]; other site 246197010846 Mg2+ binding site [ion binding]; other site 246197010847 G-X-G motif; other site 246197010848 WbqC-like protein family; Region: WbqC; pfam08889 246197010849 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 246197010850 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246197010851 active site 246197010852 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 246197010853 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246197010854 Coenzyme A binding pocket [chemical binding]; other site 246197010855 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain; Region: NMT_C; pfam02799 246197010856 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 246197010857 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 246197010858 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 246197010859 putative active site [active] 246197010860 putative PHP Thumb interface [polypeptide binding]; other site 246197010861 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 246197010862 generic binding surface I; other site 246197010863 generic binding surface II; other site 246197010864 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 246197010865 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 246197010866 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 246197010867 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 246197010868 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 246197010869 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 246197010870 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246197010871 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 246197010872 NAD(P) binding site [chemical binding]; other site 246197010873 active site 246197010874 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246197010875 phosphopeptide binding site; other site 246197010876 Y-family of DNA polymerases; Region: PolY; cl12025 246197010877 active site 246197010878 DNA binding site [nucleotide binding] 246197010879 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 246197010880 Walker A motif; other site 246197010881 ATP binding site [chemical binding]; other site 246197010882 Walker B motif; other site 246197010883 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 246197010884 metal ion-dependent adhesion site (MIDAS); other site 246197010885 Found in ATP-dependent protease La (LON); Region: LON; smart00464 246197010886 ATP-dependent protease La; Region: lon; TIGR00763 246197010887 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197010888 Walker A motif; other site 246197010889 ATP binding site [chemical binding]; other site 246197010890 Walker B motif; other site 246197010891 arginine finger; other site 246197010892 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 246197010893 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 246197010894 Bacterial SH3 domain; Region: SH3_3; cl17532 246197010895 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 246197010896 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 246197010897 active site 246197010898 metal binding site [ion binding]; metal-binding site 246197010899 Condensation domain; Region: Condensation; pfam00668 246197010900 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197010901 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246197010902 acyl-activating enzyme (AAE) consensus motif; other site 246197010903 AMP binding site [chemical binding]; other site 246197010904 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197010905 Condensation domain; Region: Condensation; pfam00668 246197010906 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197010907 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 246197010908 acyl-activating enzyme (AAE) consensus motif; other site 246197010909 AMP binding site [chemical binding]; other site 246197010910 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197010911 Condensation domain; Region: Condensation; pfam00668 246197010912 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197010913 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197010914 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246197010915 acyl-activating enzyme (AAE) consensus motif; other site 246197010916 AMP binding site [chemical binding]; other site 246197010917 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197010918 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 246197010919 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197010920 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 246197010921 acyl-activating enzyme (AAE) consensus motif; other site 246197010922 AMP binding site [chemical binding]; other site 246197010923 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197010924 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246197010925 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 246197010926 active site 246197010927 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 246197010928 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 246197010929 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197010930 Condensation domain; Region: Condensation; pfam00668 246197010931 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197010932 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197010933 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246197010934 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 246197010935 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 246197010936 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246197010937 Condensation domain; Region: Condensation; pfam00668 246197010938 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197010939 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197010940 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246197010941 acyl-activating enzyme (AAE) consensus motif; other site 246197010942 AMP binding site [chemical binding]; other site 246197010943 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197010944 Condensation domain; Region: Condensation; pfam00668 246197010945 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 246197010946 acyl-CoA synthetase; Validated; Region: PRK05850 246197010947 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 246197010948 acyl-activating enzyme (AAE) consensus motif; other site 246197010949 active site 246197010950 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197010951 Condensation domain; Region: Condensation; pfam00668 246197010952 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197010953 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197010954 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246197010955 acyl-activating enzyme (AAE) consensus motif; other site 246197010956 AMP binding site [chemical binding]; other site 246197010957 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197010958 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 246197010959 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 246197010960 active site 246197010961 catalytic tetrad [active] 246197010962 Domain of unknown function (DUF4130; Region: DUF4130; cl14836 246197010963 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 246197010964 active site 246197010965 Fe-S cluster binding site [ion binding]; other site 246197010966 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246197010967 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 246197010968 phosphopeptide binding site; other site 246197010969 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 246197010970 Domain of unknown function (DUF3943); Region: DUF3943; pfam13084 246197010971 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 246197010972 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 246197010973 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 246197010974 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 246197010975 active site 246197010976 Zn binding site [ion binding]; other site 246197010977 BNR repeat-like domain; Region: BNR_2; pfam13088 246197010978 phosphofructokinase; Region: PFK_mixed; TIGR02483 246197010979 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 246197010980 active site 246197010981 ADP/pyrophosphate binding site [chemical binding]; other site 246197010982 dimerization interface [polypeptide binding]; other site 246197010983 allosteric effector site; other site 246197010984 fructose-1,6-bisphosphate binding site; other site 246197010985 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246197010986 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197010987 active site 246197010988 ATP binding site [chemical binding]; other site 246197010989 substrate binding site [chemical binding]; other site 246197010990 activation loop (A-loop); other site 246197010991 PEGA domain; Region: PEGA; pfam08308 246197010992 FHA domain; Region: FHA; pfam00498 246197010993 phosphopeptide binding site; other site 246197010994 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 246197010995 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 246197010996 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197010997 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 246197010998 Walker A motif; other site 246197010999 ATP binding site [chemical binding]; other site 246197011000 Walker B motif; other site 246197011001 arginine finger; other site 246197011002 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 246197011003 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197011004 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 246197011005 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 246197011006 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197011007 ATP binding site [chemical binding]; other site 246197011008 Mg2+ binding site [ion binding]; other site 246197011009 G-X-G motif; other site 246197011010 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 246197011011 ATP binding site [chemical binding]; other site 246197011012 MutL C terminal dimerisation domain; Region: MutL_C; smart00853 246197011013 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 246197011014 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 246197011015 putative NAD(P) binding site [chemical binding]; other site 246197011016 active site 246197011017 putative substrate binding site [chemical binding]; other site 246197011018 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 246197011019 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 246197011020 putative acyl-acceptor binding pocket; other site 246197011021 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 246197011022 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246197011023 phosphopeptide binding site; other site 246197011024 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 246197011025 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 246197011026 metal binding site [ion binding]; metal-binding site 246197011027 active site 246197011028 I-site; other site 246197011029 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197011030 Protein of unknown function (DUF721); Region: DUF721; pfam05258 246197011031 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 246197011032 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 246197011033 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 246197011034 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 246197011035 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 246197011036 N-acetyl-D-glucosamine binding site [chemical binding]; other site 246197011037 catalytic residue [active] 246197011038 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 246197011039 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 246197011040 C-terminal domain interface [polypeptide binding]; other site 246197011041 GSH binding site (G-site) [chemical binding]; other site 246197011042 dimer interface [polypeptide binding]; other site 246197011043 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 246197011044 N-terminal domain interface [polypeptide binding]; other site 246197011045 dimer interface [polypeptide binding]; other site 246197011046 substrate binding pocket (H-site) [chemical binding]; other site 246197011047 Predicted transcriptional regulators [Transcription]; Region: COG1733 246197011048 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 246197011049 cytidylate kinase; Provisional; Region: cmk; PRK00023 246197011050 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 246197011051 CMP-binding site; other site 246197011052 The sites determining sugar specificity; other site 246197011053 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 246197011054 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246197011055 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246197011056 homodimer interface [polypeptide binding]; other site 246197011057 catalytic residue [active] 246197011058 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 246197011059 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 246197011060 TPR repeat; Region: TPR_11; pfam13414 246197011061 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197011062 binding surface 246197011063 TPR motif; other site 246197011064 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 246197011065 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 246197011066 DTAP/Switch II; other site 246197011067 Switch I; other site 246197011068 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 246197011069 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 246197011070 P loop; other site 246197011071 Nucleotide binding site [chemical binding]; other site 246197011072 DTAP/Switch II; other site 246197011073 Switch I; other site 246197011074 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 246197011075 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197011076 active site 246197011077 phosphorylation site [posttranslational modification] 246197011078 intermolecular recognition site; other site 246197011079 dimerization interface [polypeptide binding]; other site 246197011080 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197011081 Walker A motif; other site 246197011082 ATP binding site [chemical binding]; other site 246197011083 Walker B motif; other site 246197011084 arginine finger; other site 246197011085 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 246197011086 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197011087 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 246197011088 phosphorylation site [posttranslational modification] 246197011089 dimer interface [polypeptide binding]; other site 246197011090 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 246197011091 catalytic motif [active] 246197011092 Zn binding site [ion binding]; other site 246197011093 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 246197011094 PrkA AAA domain; Region: AAA_PrkA; smart00763 246197011095 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 246197011096 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 246197011097 MreB/Mbl protein; Region: MreB_Mbl; pfam06723 246197011098 nucleotide binding site [chemical binding]; other site 246197011099 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197011100 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197011101 active site 246197011102 ATP binding site [chemical binding]; other site 246197011103 substrate binding site [chemical binding]; other site 246197011104 activation loop (A-loop); other site 246197011105 Response regulator receiver domain; Region: Response_reg; pfam00072 246197011106 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197011107 active site 246197011108 phosphorylation site [posttranslational modification] 246197011109 intermolecular recognition site; other site 246197011110 dimerization interface [polypeptide binding]; other site 246197011111 Adenylyl- / guanylyl cyclase, catalytic domain; Region: CYCc; smart00044 246197011112 cyclase homology domain; Region: CHD; cd07302 246197011113 nucleotidyl binding site; other site 246197011114 metal binding site [ion binding]; metal-binding site 246197011115 dimer interface [polypeptide binding]; other site 246197011116 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 246197011117 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 246197011118 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 246197011119 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 246197011120 HIGH motif; other site 246197011121 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 246197011122 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 246197011123 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 246197011124 active site 246197011125 KMSKS motif; other site 246197011126 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 246197011127 tRNA binding surface [nucleotide binding]; other site 246197011128 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 246197011129 phytoene desaturase; Region: crtI_fam; TIGR02734 246197011130 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 246197011131 Protein kinase domain; Region: Pkinase; pfam00069 246197011132 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246197011133 substrate binding site [chemical binding]; other site 246197011134 activation loop (A-loop); other site 246197011135 AAA ATPase domain; Region: AAA_16; pfam13191 246197011136 Predicted ATPase [General function prediction only]; Region: COG3899 246197011137 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 246197011138 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 246197011139 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197011140 ATP binding site [chemical binding]; other site 246197011141 Mg2+ binding site [ion binding]; other site 246197011142 G-X-G motif; other site 246197011143 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 246197011144 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 246197011145 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 246197011146 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197011147 Walker A motif; other site 246197011148 ATP binding site [chemical binding]; other site 246197011149 Walker B motif; other site 246197011150 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 246197011151 Pseudouridylate synthase [Translation, ribosomal structure and biogenesis]; Region: TruA; COG0101 246197011152 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 246197011153 active site 246197011154 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 246197011155 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 246197011156 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246197011157 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246197011158 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 246197011159 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 246197011160 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 246197011161 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 246197011162 Ligand Binding Site [chemical binding]; other site 246197011163 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 246197011164 ligand-binding site [chemical binding]; other site 246197011165 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 246197011166 MPN+ (JAMM) motif; other site 246197011167 Zinc-binding site [ion binding]; other site 246197011168 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 246197011169 ATP binding site [chemical binding]; other site 246197011170 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 246197011171 MoaE interaction surface [polypeptide binding]; other site 246197011172 thiocarboxylated glycine; other site 246197011173 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 246197011174 CPxP motif; other site 246197011175 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 246197011176 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 246197011177 ATP binding site [chemical binding]; other site 246197011178 substrate interface [chemical binding]; other site 246197011179 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 246197011180 Histidine kinase; Region: HisKA_3; pfam07730 246197011181 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197011182 ATP binding site [chemical binding]; other site 246197011183 Mg2+ binding site [ion binding]; other site 246197011184 G-X-G motif; other site 246197011185 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246197011186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197011187 active site 246197011188 phosphorylation site [posttranslational modification] 246197011189 intermolecular recognition site; other site 246197011190 dimerization interface [polypeptide binding]; other site 246197011191 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246197011192 DNA binding residues [nucleotide binding] 246197011193 dimerization interface [polypeptide binding]; other site 246197011194 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 246197011195 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 246197011196 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 246197011197 Walker A/P-loop; other site 246197011198 ATP binding site [chemical binding]; other site 246197011199 Q-loop/lid; other site 246197011200 ABC transporter signature motif; other site 246197011201 Walker B; other site 246197011202 D-loop; other site 246197011203 H-loop/switch region; other site 246197011204 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 246197011205 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 246197011206 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 246197011207 Zn binding site [ion binding]; other site 246197011208 Protein of unknown function (DUF2378); Region: DUF2378; pfam09536 246197011209 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 246197011210 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246197011211 active site 246197011212 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 246197011213 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 246197011214 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246197011215 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 246197011216 NAD(P) binding site [chemical binding]; other site 246197011217 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 246197011218 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 246197011219 putative NADP binding site [chemical binding]; other site 246197011220 active site 246197011221 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 246197011222 Condensation domain; Region: Condensation; pfam00668 246197011223 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197011224 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197011225 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246197011226 acyl-activating enzyme (AAE) consensus motif; other site 246197011227 AMP binding site [chemical binding]; other site 246197011228 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197011229 S-adenosylmethionine binding site [chemical binding]; other site 246197011230 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246197011231 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197011232 Condensation domain; Region: Condensation; pfam00668 246197011233 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197011234 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197011235 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246197011236 acyl-activating enzyme (AAE) consensus motif; other site 246197011237 AMP binding site [chemical binding]; other site 246197011238 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197011239 Condensation domain; Region: Condensation; pfam00668 246197011240 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197011241 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 246197011242 Condensation domain; Region: Condensation; pfam00668 246197011243 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246197011244 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 246197011245 acyl-activating enzyme (AAE) consensus motif; other site 246197011246 AMP binding site [chemical binding]; other site 246197011247 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197011248 Condensation domain; Region: Condensation; pfam00668 246197011249 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197011250 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197011251 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246197011252 acyl-activating enzyme (AAE) consensus motif; other site 246197011253 AMP binding site [chemical binding]; other site 246197011254 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197011255 Condensation domain; Region: Condensation; pfam00668 246197011256 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197011257 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197011258 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246197011259 acyl-activating enzyme (AAE) consensus motif; other site 246197011260 AMP binding site [chemical binding]; other site 246197011261 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197011262 Condensation domain; Region: Condensation; pfam00668 246197011263 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197011264 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197011265 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246197011266 acyl-activating enzyme (AAE) consensus motif; other site 246197011267 AMP binding site [chemical binding]; other site 246197011268 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197011269 Thioesterase domain; Region: Thioesterase; pfam00975 246197011270 Predicted integral membrane protein (DUF2269); Region: DUF2269; pfam10027 246197011271 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 246197011272 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 246197011273 ATP binding site [chemical binding]; other site 246197011274 Mg++ binding site [ion binding]; other site 246197011275 motif III; other site 246197011276 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246197011277 nucleotide binding region [chemical binding]; other site 246197011278 ATP-binding site [chemical binding]; other site 246197011279 elongation factor G; Reviewed; Region: PRK00007 246197011280 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 246197011281 G1 box; other site 246197011282 putative GEF interaction site [polypeptide binding]; other site 246197011283 GTP/Mg2+ binding site [chemical binding]; other site 246197011284 Switch I region; other site 246197011285 G2 box; other site 246197011286 G3 box; other site 246197011287 Switch II region; other site 246197011288 G4 box; other site 246197011289 G5 box; other site 246197011290 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 246197011291 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 246197011292 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 246197011293 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 246197011294 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 246197011295 ligand binding site [chemical binding]; other site 246197011296 flexible hinge region; other site 246197011297 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 246197011298 phosphodiesterase YaeI; Provisional; Region: PRK11340 246197011299 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 246197011300 putative active site [active] 246197011301 putative metal binding site [ion binding]; other site 246197011302 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 246197011303 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 246197011304 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246197011305 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246197011306 DNA binding residues [nucleotide binding] 246197011307 Antirepressor CarS; Region: CarS; cd12840 246197011308 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 246197011309 Domain of unknown function DUF20; Region: UPF0118; pfam01594 246197011310 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 246197011311 homodimer interface [polypeptide binding]; other site 246197011312 homotetramer interface [polypeptide binding]; other site 246197011313 active site pocket [active] 246197011314 cleavage site 246197011315 D-alanine--D-alanine ligase; Region: D_ala_D_alaTIGR; TIGR01205 246197011316 ATP-grasp domain; Region: ATP-grasp_4; cl17255 246197011317 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 246197011318 D-alanine--D-alanine ligase; Region: D_ala_D_alaTIGR; TIGR01205 246197011319 ATP-grasp domain; Region: ATP-grasp_4; cl17255 246197011320 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 246197011321 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 246197011322 dimer interface [polypeptide binding]; other site 246197011323 active site 246197011324 Schiff base residues; other site 246197011325 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 246197011326 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 246197011327 Walker A/P-loop; other site 246197011328 ATP binding site [chemical binding]; other site 246197011329 Q-loop/lid; other site 246197011330 ABC transporter signature motif; other site 246197011331 Walker B; other site 246197011332 D-loop; other site 246197011333 H-loop/switch region; other site 246197011334 Cytochrome c; Region: Cytochrom_C; pfam00034 246197011335 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 246197011336 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 246197011337 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 246197011338 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246197011339 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246197011340 LysR substrate binding domain; Region: LysR_substrate; pfam03466 246197011341 dimerization interface [polypeptide binding]; other site 246197011342 Pirin-related protein [General function prediction only]; Region: COG1741 246197011343 Pirin; Region: Pirin; pfam02678 246197011344 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 246197011345 Dihydroneopterin aldolase; Region: FolB; smart00905 246197011346 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 246197011347 Mechanosensitive ion channel; Region: MS_channel; pfam00924 246197011348 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 246197011349 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 246197011350 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 246197011351 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 246197011352 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 246197011353 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 246197011354 RNA polymerase sigma factor SigZ; Provisional; Region: PRK09637 246197011355 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246197011356 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 246197011357 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 246197011358 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 246197011359 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 246197011360 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 246197011361 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 246197011362 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246197011363 Cytochrome P450; Region: p450; cl12078 246197011364 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 246197011365 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 246197011366 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 246197011367 structural tetrad; other site 246197011368 PQQ-like domain; Region: PQQ_2; pfam13360 246197011369 PQQ-like domain; Region: PQQ_2; pfam13360 246197011370 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 246197011371 structural tetrad; other site 246197011372 PQQ-like domain; Region: PQQ_2; pfam13360 246197011373 SIR2-like domain; Region: SIR2_2; pfam13289 246197011374 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 246197011375 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 246197011376 Immediate early response protein (IER); Region: IER; pfam05760 246197011377 photolyase PhrII; Region: phr2; TIGR00591 246197011378 DNA photolyase; Region: DNA_photolyase; pfam00875 246197011379 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865 246197011380 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 246197011381 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 246197011382 Tetratricopeptide repeat; Region: TPR_16; pfam13432 246197011383 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197011384 TPR motif; other site 246197011385 binding surface 246197011386 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197011387 binding surface 246197011388 Tetratricopeptide repeat; Region: TPR_16; pfam13432 246197011389 TPR motif; other site 246197011390 TPR repeat; Region: TPR_11; pfam13414 246197011391 CheB methylesterase; Region: CheB_methylest; pfam01339 246197011392 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 246197011393 putative binding surface; other site 246197011394 active site 246197011395 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197011396 ATP binding site [chemical binding]; other site 246197011397 Mg2+ binding site [ion binding]; other site 246197011398 G-X-G motif; other site 246197011399 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 246197011400 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 246197011401 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197011402 active site 246197011403 phosphorylation site [posttranslational modification] 246197011404 intermolecular recognition site; other site 246197011405 dimerization interface [polypeptide binding]; other site 246197011406 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 246197011407 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 246197011408 dimer interface [polypeptide binding]; other site 246197011409 putative CheW interface [polypeptide binding]; other site 246197011410 Two component signalling adaptor domain; Region: CheW; smart00260 246197011411 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 246197011412 putative CheA interaction surface; other site 246197011413 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 246197011414 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197011415 active site 246197011416 phosphorylation site [posttranslational modification] 246197011417 intermolecular recognition site; other site 246197011418 dimerization interface [polypeptide binding]; other site 246197011419 Response regulator receiver domain; Region: Response_reg; pfam00072 246197011420 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197011421 active site 246197011422 phosphorylation site [posttranslational modification] 246197011423 intermolecular recognition site; other site 246197011424 dimerization interface [polypeptide binding]; other site 246197011425 Radical SAM superfamily; Region: Radical_SAM; pfam04055 246197011426 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246197011427 FeS/SAM binding site; other site 246197011428 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 246197011429 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 246197011430 hexamer interface [polypeptide binding]; other site 246197011431 ligand binding site [chemical binding]; other site 246197011432 putative active site [active] 246197011433 NAD(P) binding site [chemical binding]; other site 246197011434 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 246197011435 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246197011436 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246197011437 DNA binding residues [nucleotide binding] 246197011438 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 246197011439 Putative zinc-finger; Region: zf-HC2; pfam13490 246197011440 Response regulator receiver domain; Region: Response_reg; pfam00072 246197011441 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197011442 active site 246197011443 phosphorylation site [posttranslational modification] 246197011444 intermolecular recognition site; other site 246197011445 dimerization interface [polypeptide binding]; other site 246197011446 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 246197011447 pantothenate kinase; Reviewed; Region: PRK13321 246197011448 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 246197011449 Biotin operon repressor [Transcription]; Region: BirA; COG1654 246197011450 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 246197011451 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 246197011452 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 246197011453 HEAT repeats; Region: HEAT_2; pfam13646 246197011454 Restriction endonuclease; Region: Mrr_cat; pfam04471 246197011455 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 246197011456 active site 246197011457 PQQ-like domain; Region: PQQ_2; pfam13360 246197011458 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 246197011459 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 246197011460 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 246197011461 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 246197011462 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 246197011463 ATP-binding site [chemical binding]; other site 246197011464 Sugar specificity; other site 246197011465 Pyrimidine base specificity; other site 246197011466 Protein of unknown function (DUF692); Region: DUF692; cl01263 246197011467 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 246197011468 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246197011469 Coenzyme A binding pocket [chemical binding]; other site 246197011470 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 246197011471 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197011472 active site 246197011473 phosphorylation site [posttranslational modification] 246197011474 intermolecular recognition site; other site 246197011475 dimerization interface [polypeptide binding]; other site 246197011476 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 246197011477 DNA binding site [nucleotide binding] 246197011478 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197011479 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197011480 dimer interface [polypeptide binding]; other site 246197011481 phosphorylation site [posttranslational modification] 246197011482 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197011483 ATP binding site [chemical binding]; other site 246197011484 Mg2+ binding site [ion binding]; other site 246197011485 G-X-G motif; other site 246197011486 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 246197011487 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 246197011488 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 246197011489 dimer interface [polypeptide binding]; other site 246197011490 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246197011491 catalytic residue [active] 246197011492 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 246197011493 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 246197011494 FtsX-like permease family; Region: FtsX; pfam02687 246197011495 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 246197011496 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 246197011497 FtsX-like permease family; Region: FtsX; pfam02687 246197011498 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 246197011499 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 246197011500 Walker A/P-loop; other site 246197011501 ATP binding site [chemical binding]; other site 246197011502 Q-loop/lid; other site 246197011503 ABC transporter signature motif; other site 246197011504 Walker B; other site 246197011505 D-loop; other site 246197011506 H-loop/switch region; other site 246197011507 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 246197011508 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 246197011509 HlyD family secretion protein; Region: HlyD_3; pfam13437 246197011510 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 246197011511 Yip1 domain; Region: Yip1; pfam04893 246197011512 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197011513 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 246197011514 Walker A motif; other site 246197011515 ATP binding site [chemical binding]; other site 246197011516 Walker B motif; other site 246197011517 arginine finger; other site 246197011518 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197011519 Walker A motif; other site 246197011520 ATP binding site [chemical binding]; other site 246197011521 Walker B motif; other site 246197011522 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 246197011523 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 246197011524 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 246197011525 Immediate early response protein (IER); Region: IER; pfam05760 246197011526 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 246197011527 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 246197011528 active site 246197011529 (T/H)XGH motif; other site 246197011530 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 246197011531 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 246197011532 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 246197011533 cyclase homology domain; Region: CHD; cd07302 246197011534 nucleotidyl binding site; other site 246197011535 metal binding site [ion binding]; metal-binding site 246197011536 dimer interface [polypeptide binding]; other site 246197011537 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197011538 binding surface 246197011539 TPR motif; other site 246197011540 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 246197011541 binding surface 246197011542 TPR motif; other site 246197011543 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 246197011544 MutS domain III; Region: MutS_III; pfam05192 246197011545 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246197011546 Walker A/P-loop; other site 246197011547 ATP binding site [chemical binding]; other site 246197011548 Q-loop/lid; other site 246197011549 ABC transporter signature motif; other site 246197011550 Walker B; other site 246197011551 D-loop; other site 246197011552 H-loop/switch region; other site 246197011553 Smr domain; Region: Smr; pfam01713 246197011554 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 246197011555 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 246197011556 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 246197011557 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 246197011558 binding surface 246197011559 Tetratricopeptide repeat; Region: TPR_16; pfam13432 246197011560 TPR motif; other site 246197011561 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 246197011562 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197011563 active site 246197011564 phosphorylation site [posttranslational modification] 246197011565 intermolecular recognition site; other site 246197011566 dimerization interface [polypeptide binding]; other site 246197011567 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197011568 Walker A motif; other site 246197011569 ATP binding site [chemical binding]; other site 246197011570 Walker B motif; other site 246197011571 arginine finger; other site 246197011572 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 246197011573 sensor protein ZraS; Provisional; Region: PRK10364 246197011574 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197011575 dimer interface [polypeptide binding]; other site 246197011576 phosphorylation site [posttranslational modification] 246197011577 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197011578 ATP binding site [chemical binding]; other site 246197011579 Mg2+ binding site [ion binding]; other site 246197011580 G-X-G motif; other site 246197011581 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 246197011582 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 246197011583 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 246197011584 Walker A/P-loop; other site 246197011585 ATP binding site [chemical binding]; other site 246197011586 Q-loop/lid; other site 246197011587 ABC transporter signature motif; other site 246197011588 Walker B; other site 246197011589 D-loop; other site 246197011590 H-loop/switch region; other site 246197011591 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 246197011592 HlyD family secretion protein; Region: HlyD_3; pfam13437 246197011593 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 246197011594 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 246197011595 FtsX-like permease family; Region: FtsX; pfam02687 246197011596 Response regulator receiver domain; Region: Response_reg; pfam00072 246197011597 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197011598 active site 246197011599 phosphorylation site [posttranslational modification] 246197011600 intermolecular recognition site; other site 246197011601 dimerization interface [polypeptide binding]; other site 246197011602 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197011603 ATP binding site [chemical binding]; other site 246197011604 Mg2+ binding site [ion binding]; other site 246197011605 G-X-G motif; other site 246197011606 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 246197011607 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 246197011608 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246197011609 NAD(P) binding site [chemical binding]; other site 246197011610 active site 246197011611 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 246197011612 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 246197011613 putative active site [active] 246197011614 putative metal binding site [ion binding]; other site 246197011615 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197011616 binding surface 246197011617 TPR motif; other site 246197011618 TPR repeat; Region: TPR_11; pfam13414 246197011619 Protein of unknown function (DUF3185); Region: DUF3185; pfam11381 246197011620 ribonuclease R; Region: RNase_R; TIGR02063 246197011621 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 246197011622 RNB domain; Region: RNB; pfam00773 246197011623 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 246197011624 RNA binding site [nucleotide binding]; other site 246197011625 Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394 246197011626 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 246197011627 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 246197011628 dimer interface [polypeptide binding]; other site 246197011629 putative functional site; other site 246197011630 putative MPT binding site; other site 246197011631 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 246197011632 dimerization interface [polypeptide binding]; other site 246197011633 active site 246197011634 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 246197011635 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 246197011636 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 246197011637 nudix motif; other site 246197011638 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 246197011639 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 246197011640 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 246197011641 E3 interaction surface; other site 246197011642 lipoyl attachment site [posttranslational modification]; other site 246197011643 e3 binding domain; Region: E3_binding; pfam02817 246197011644 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 246197011645 lipoyl synthase; Provisional; Region: PRK05481 246197011646 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246197011647 FeS/SAM binding site; other site 246197011648 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 246197011649 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 246197011650 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 246197011651 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 246197011652 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 246197011653 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 246197011654 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 246197011655 metal binding site [ion binding]; metal-binding site 246197011656 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 246197011657 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 246197011658 active site 246197011659 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 246197011660 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 246197011661 substrate binding site [chemical binding]; other site 246197011662 glutamase interaction surface [polypeptide binding]; other site 246197011663 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cl00341 246197011664 putative active site pocket [active] 246197011665 4-fold oligomerization interface [polypeptide binding]; other site 246197011666 metal binding residues [ion binding]; metal-binding site 246197011667 3-fold/trimer interface [polypeptide binding]; other site 246197011668 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 246197011669 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 246197011670 catalytic residues [active] 246197011671 Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118 246197011672 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 246197011673 putative active site [active] 246197011674 oxyanion strand; other site 246197011675 catalytic triad [active] 246197011676 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 246197011677 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246197011678 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246197011679 homodimer interface [polypeptide binding]; other site 246197011680 catalytic residue [active] 246197011681 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 246197011682 histidinol dehydrogenase; Region: hisD; TIGR00069 246197011683 NAD binding site [chemical binding]; other site 246197011684 dimerization interface [polypeptide binding]; other site 246197011685 product binding site; other site 246197011686 substrate binding site [chemical binding]; other site 246197011687 zinc binding site [ion binding]; other site 246197011688 catalytic residues [active] 246197011689 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 246197011690 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 246197011691 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 246197011692 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 246197011693 hydroxyglutarate oxidase; Provisional; Region: PRK11728 246197011694 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 246197011695 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197011696 active site 246197011697 phosphorylation site [posttranslational modification] 246197011698 intermolecular recognition site; other site 246197011699 dimerization interface [polypeptide binding]; other site 246197011700 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 246197011701 Zn2+ binding site [ion binding]; other site 246197011702 Mg2+ binding site [ion binding]; other site 246197011703 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 246197011704 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246197011705 FeS/SAM binding site; other site 246197011706 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 246197011707 Tic20-like protein; Region: Tic20; pfam09685 246197011708 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 246197011709 ThiC-associated domain; Region: ThiC-associated; pfam13667 246197011710 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 246197011711 FOG: CBS domain [General function prediction only]; Region: COG0517 246197011712 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_15; cd04803 246197011713 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 246197011714 transmembrane helices; other site 246197011715 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 246197011716 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 246197011717 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197011718 active site 246197011719 phosphorylation site [posttranslational modification] 246197011720 intermolecular recognition site; other site 246197011721 dimerization interface [polypeptide binding]; other site 246197011722 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197011723 Walker A motif; other site 246197011724 ATP binding site [chemical binding]; other site 246197011725 Walker B motif; other site 246197011726 arginine finger; other site 246197011727 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 246197011728 Penicillinase repressor; Region: Pencillinase_R; pfam03965 246197011729 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 246197011730 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 246197011731 Response regulator receiver domain; Region: Response_reg; pfam00072 246197011732 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197011733 active site 246197011734 phosphorylation site [posttranslational modification] 246197011735 intermolecular recognition site; other site 246197011736 dimerization interface [polypeptide binding]; other site 246197011737 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197011738 dimer interface [polypeptide binding]; other site 246197011739 phosphorylation site [posttranslational modification] 246197011740 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197011741 ATP binding site [chemical binding]; other site 246197011742 Mg2+ binding site [ion binding]; other site 246197011743 G-X-G motif; other site 246197011744 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197011745 Response regulator receiver domain; Region: Response_reg; pfam00072 246197011746 active site 246197011747 phosphorylation site [posttranslational modification] 246197011748 intermolecular recognition site; other site 246197011749 dimerization interface [polypeptide binding]; other site 246197011750 Response regulator receiver domain; Region: Response_reg; pfam00072 246197011751 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197011752 active site 246197011753 phosphorylation site [posttranslational modification] 246197011754 intermolecular recognition site; other site 246197011755 dimerization interface [polypeptide binding]; other site 246197011756 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 246197011757 heme-binding site [chemical binding]; other site 246197011758 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197011759 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197011760 dimer interface [polypeptide binding]; other site 246197011761 phosphorylation site [posttranslational modification] 246197011762 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197011763 ATP binding site [chemical binding]; other site 246197011764 Mg2+ binding site [ion binding]; other site 246197011765 G-X-G motif; other site 246197011766 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246197011767 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246197011768 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_1; cd08421 246197011769 putative dimerization interface [polypeptide binding]; other site 246197011770 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 246197011771 putative hydrophobic ligand binding site [chemical binding]; other site 246197011772 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 246197011773 active site 246197011774 PAS fold; Region: PAS_4; pfam08448 246197011775 PAS fold; Region: PAS_3; pfam08447 246197011776 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 246197011777 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197011778 phosphorylation site [posttranslational modification] 246197011779 dimer interface [polypeptide binding]; other site 246197011780 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197011781 ATP binding site [chemical binding]; other site 246197011782 Mg2+ binding site [ion binding]; other site 246197011783 G-X-G motif; other site 246197011784 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 246197011785 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197011786 active site 246197011787 phosphorylation site [posttranslational modification] 246197011788 intermolecular recognition site; other site 246197011789 dimerization interface [polypeptide binding]; other site 246197011790 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197011791 Walker A motif; other site 246197011792 ATP binding site [chemical binding]; other site 246197011793 Walker B motif; other site 246197011794 arginine finger; other site 246197011795 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 246197011796 Response regulator receiver domain; Region: Response_reg; pfam00072 246197011797 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197011798 active site 246197011799 phosphorylation site [posttranslational modification] 246197011800 intermolecular recognition site; other site 246197011801 dimerization interface [polypeptide binding]; other site 246197011802 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 246197011803 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 246197011804 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 246197011805 ligand binding site [chemical binding]; other site 246197011806 FecR protein; Region: FecR; pfam04773 246197011807 CHASE2 is an extracellular sensory domain, which is present in various classes of transmembrane receptors that are parts of signal transduction pathways in bacteria; Region: CHASE2; smart01080 246197011808 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246197011809 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197011810 active site 246197011811 phosphorylation site [posttranslational modification] 246197011812 intermolecular recognition site; other site 246197011813 dimerization interface [polypeptide binding]; other site 246197011814 GAF domain; Region: GAF; pfam01590 246197011815 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 246197011816 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 246197011817 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 246197011818 metal binding site [ion binding]; metal-binding site 246197011819 active site 246197011820 I-site; other site 246197011821 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 246197011822 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 246197011823 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197011824 active site 246197011825 phosphorylation site [posttranslational modification] 246197011826 intermolecular recognition site; other site 246197011827 dimerization interface [polypeptide binding]; other site 246197011828 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197011829 Walker A motif; other site 246197011830 ATP binding site [chemical binding]; other site 246197011831 Walker B motif; other site 246197011832 arginine finger; other site 246197011833 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 246197011834 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 246197011835 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197011836 dimer interface [polypeptide binding]; other site 246197011837 phosphorylation site [posttranslational modification] 246197011838 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197011839 ATP binding site [chemical binding]; other site 246197011840 G-X-G motif; other site 246197011841 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246197011842 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246197011843 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 246197011844 Coenzyme A transferase; Region: CoA_trans; cl17247 246197011845 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 246197011846 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 246197011847 NAD(P) binding site [chemical binding]; other site 246197011848 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 246197011849 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 246197011850 dimer interface [polypeptide binding]; other site 246197011851 active site 246197011852 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 246197011853 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 246197011854 putative dimer interface [polypeptide binding]; other site 246197011855 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 246197011856 SnoaL-like domain; Region: SnoaL_3; pfam13474 246197011857 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 246197011858 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 246197011859 Soluble P-type ATPase [General function prediction only]; Region: COG4087 246197011860 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 246197011861 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 246197011862 serpin-like protein; Provisional; Region: PHA02660 246197011863 reactive center loop; other site 246197011864 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 246197011865 cleavage site 246197011866 active site 246197011867 substrate binding sites [chemical binding]; other site 246197011868 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 246197011869 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 246197011870 DEAD-like helicases superfamily; Region: DEXDc; smart00487 246197011871 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 246197011872 putative Mg++ binding site [ion binding]; other site 246197011873 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246197011874 nucleotide binding region [chemical binding]; other site 246197011875 ATP-binding site [chemical binding]; other site 246197011876 Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117 246197011877 homodimer interface [polypeptide binding]; other site 246197011878 putative active site [active] 246197011879 catalytic site [active] 246197011880 thiocyanate hydrolase, gamma subunit; Region: thiocyan_alph; TIGR03887 246197011881 Cupin superfamily protein; Region: Cupin_4; pfam08007 246197011882 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 246197011883 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 246197011884 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 246197011885 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246197011886 active site 246197011887 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 246197011888 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 246197011889 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 246197011890 KR domain; Region: KR; pfam08659 246197011891 putative NADP binding site [chemical binding]; other site 246197011892 active site 246197011893 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 246197011894 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 246197011895 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 246197011896 DTAP/Switch II; other site 246197011897 Patatin-like phospholipase; Region: Pat17_PNPLA8_PNPLA9_like1; cd07213 246197011898 active site 246197011899 nucleophile elbow; other site 246197011900 Condensation domain; Region: Condensation; pfam00668 246197011901 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197011902 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197011903 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246197011904 acyl-activating enzyme (AAE) consensus motif; other site 246197011905 AMP binding site [chemical binding]; other site 246197011906 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197011907 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 246197011908 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 246197011909 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246197011910 active site 246197011911 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 246197011912 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 246197011913 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 246197011914 putative NADP binding site [chemical binding]; other site 246197011915 KR domain; Region: KR; pfam08659 246197011916 active site 246197011917 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 246197011918 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 246197011919 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246197011920 active site 246197011921 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 246197011922 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 246197011923 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 246197011924 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 246197011925 putative NADP binding site [chemical binding]; other site 246197011926 KR domain; Region: KR; pfam08659 246197011927 active site 246197011928 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 246197011929 Condensation domain; Region: Condensation; pfam00668 246197011930 Nonribosomal peptide synthase; Region: NRPS; pfam08415 246197011931 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 246197011932 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 246197011933 acyl-activating enzyme (AAE) consensus motif; other site 246197011934 AMP binding site [chemical binding]; other site 246197011935 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197011936 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 246197011937 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246197011938 active site 246197011939 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 246197011940 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 246197011941 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 246197011942 putative NADP binding site [chemical binding]; other site 246197011943 KR domain; Region: KR; pfam08659 246197011944 active site 246197011945 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 246197011946 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246197011947 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 246197011948 active site 246197011949 Acyl transferase domain; Region: Acyl_transf_1; cl08282 246197011950 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 246197011951 putative NADP binding site [chemical binding]; other site 246197011952 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 246197011953 active site 246197011954 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197011955 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246197011956 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 246197011957 active site 246197011958 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 246197011959 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 246197011960 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 246197011961 Uncharacterized conserved protein [Function unknown]; Region: COG3379 246197011962 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246197011963 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246197011964 active site 246197011965 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 246197011966 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 246197011967 acyl-activating enzyme (AAE) consensus motif; other site 246197011968 AMP binding site [chemical binding]; other site 246197011969 T-complex protein 1, delta subunit; Region: chap_CCT_delta; TIGR02342 246197011970 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 246197011971 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 246197011972 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246197011973 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246197011974 DNA binding residues [nucleotide binding] 246197011975 DsrE/DsrF-like family; Region: DrsE; pfam02635 246197011976 Predicted membrane protein [Function unknown]; Region: COG2855 246197011977 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 246197011978 Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411 246197011979 active site 246197011980 metal binding site [ion binding]; metal-binding site 246197011981 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 246197011982 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 246197011983 active site residue [active] 246197011984 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 246197011985 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 246197011986 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 246197011987 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246197011988 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246197011989 DNA binding residues [nucleotide binding] 246197011990 Predicted transporter component [General function prediction only]; Region: COG2391 246197011991 Sulphur transport; Region: Sulf_transp; pfam04143 246197011992 Domain of unknown function (DUF4341); Region: DUF4341; pfam14241 246197011993 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 246197011994 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 246197011995 active site residue [active] 246197011996 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 246197011997 Methyltransferase domain; Region: Methyltransf_23; pfam13489 246197011998 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197011999 S-adenosylmethionine binding site [chemical binding]; other site 246197012000 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 246197012001 Protein of unknown function (DUF2381); Region: DUF2381; pfam09544 246197012002 glutamate dehydrogenase; Region: PLN02477 246197012003 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 246197012004 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 246197012005 NAD(P) binding site [chemical binding]; other site 246197012006 PilZ domain; Region: PilZ; pfam07238 246197012007 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 246197012008 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 246197012009 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 246197012010 protein binding site [polypeptide binding]; other site 246197012011 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 246197012012 protein binding site [polypeptide binding]; other site 246197012013 GrpE; Region: GrpE; pfam01025 246197012014 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 246197012015 dimer interface [polypeptide binding]; other site 246197012016 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 246197012017 anthranilate synthase component I; Provisional; Region: PRK13572 246197012018 FtsH Extracellular; Region: FtsH_ext; pfam06480 246197012019 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 246197012020 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197012021 Walker A motif; other site 246197012022 ATP binding site [chemical binding]; other site 246197012023 Walker B motif; other site 246197012024 arginine finger; other site 246197012025 Peptidase family M41; Region: Peptidase_M41; pfam01434 246197012026 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 246197012027 active site 246197012028 8-oxo-dGMP binding site [chemical binding]; other site 246197012029 nudix motif; other site 246197012030 metal binding site [ion binding]; metal-binding site 246197012031 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246197012032 non-specific DNA binding site [nucleotide binding]; other site 246197012033 salt bridge; other site 246197012034 sequence-specific DNA binding site [nucleotide binding]; other site 246197012035 serine/threonine protein kinase; Provisional; Region: PRK14879 246197012036 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246197012037 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197012038 substrate binding site [chemical binding]; other site 246197012039 activation loop (A-loop); other site 246197012040 Tetratricopeptide repeat; Region: TPR_12; pfam13424 246197012041 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246197012042 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 246197012043 phosphopeptide binding site; other site 246197012044 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 246197012045 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197012046 Walker A motif; other site 246197012047 ATP binding site [chemical binding]; other site 246197012048 Walker B motif; other site 246197012049 arginine finger; other site 246197012050 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 246197012051 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 246197012052 putative molybdopterin cofactor binding site [chemical binding]; other site 246197012053 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 246197012054 putative molybdopterin cofactor binding site; other site 246197012055 BON domain; Region: BON; pfam04972 246197012056 urocanate hydratase; Provisional; Region: PRK05414 246197012057 imidazolonepropionase; Validated; Region: PRK09356 246197012058 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 246197012059 active site 246197012060 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 246197012061 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 246197012062 putative active site [active] 246197012063 putative dimer interface [polypeptide binding]; other site 246197012064 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 246197012065 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 246197012066 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 246197012067 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 246197012068 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 246197012069 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 246197012070 putative substrate binding site [chemical binding]; other site 246197012071 putative ATP binding site [chemical binding]; other site 246197012072 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 246197012073 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 246197012074 active site 246197012075 hydrophilic channel; other site 246197012076 dimerization interface [polypeptide binding]; other site 246197012077 catalytic residues [active] 246197012078 active site lid [active] 246197012079 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 246197012080 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 246197012081 active site 246197012082 substrate binding site [chemical binding]; other site 246197012083 metal binding site [ion binding]; metal-binding site 246197012084 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 246197012085 dihydropteroate synthase; Region: DHPS; TIGR01496 246197012086 substrate binding pocket [chemical binding]; other site 246197012087 dimer interface [polypeptide binding]; other site 246197012088 inhibitor binding site; inhibition site 246197012089 OsmC-like protein; Region: OsmC; pfam02566 246197012090 Uncharacterized conserved protein [Function unknown]; Region: COG2353 246197012091 LysR family transcriptional regulator; Provisional; Region: PRK14997 246197012092 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246197012093 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 246197012094 putative effector binding pocket; other site 246197012095 dimerization interface [polypeptide binding]; other site 246197012096 Pirin-related protein [General function prediction only]; Region: COG1741 246197012097 Pirin; Region: Pirin; pfam02678 246197012098 Pirin-related protein [General function prediction only]; Region: COG1741 246197012099 Pirin; Region: Pirin; pfam02678 246197012100 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 246197012101 FtsH Extracellular; Region: FtsH_ext; pfam06480 246197012102 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 246197012103 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 246197012104 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197012105 Walker A motif; other site 246197012106 ATP binding site [chemical binding]; other site 246197012107 Walker B motif; other site 246197012108 arginine finger; other site 246197012109 Peptidase family M41; Region: Peptidase_M41; pfam01434 246197012110 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 246197012111 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 246197012112 Ligand Binding Site [chemical binding]; other site 246197012113 TilS substrate C-terminal domain; Region: TilS_C; smart00977 246197012114 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 246197012115 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 246197012116 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 246197012117 N-terminal plug; other site 246197012118 ligand-binding site [chemical binding]; other site 246197012119 Protein of unknown function, DUF399; Region: DUF399; cl01139 246197012120 SigmaW regulon antibacterial; Region: YdfA_immunity; cl12057 246197012121 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197012122 S-adenosylmethionine binding site [chemical binding]; other site 246197012123 DNA methylase; Region: N6_N4_Mtase; cl17433 246197012124 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 246197012125 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246197012126 NAD(P) binding site [chemical binding]; other site 246197012127 active site 246197012128 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197012129 active site 246197012130 ATP binding site [chemical binding]; other site 246197012131 substrate binding site [chemical binding]; other site 246197012132 activation loop (A-loop); other site 246197012133 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246197012134 non-specific DNA binding site [nucleotide binding]; other site 246197012135 salt bridge; other site 246197012136 sequence-specific DNA binding site [nucleotide binding]; other site 246197012137 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197012138 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197012139 active site 246197012140 ATP binding site [chemical binding]; other site 246197012141 substrate binding site [chemical binding]; other site 246197012142 activation loop (A-loop); other site 246197012143 Myxococcus xanthus paralogous family TIGR02268; Region: TIGR02268 246197012144 Protein of unknown function (DUF2379); Region: DUF2379; pfam09543 246197012145 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 246197012146 DUSAM domain; Region: TIGR02267 246197012147 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 246197012148 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 246197012149 active site 2 [active] 246197012150 active site 1 [active] 246197012151 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 246197012152 B12 binding domain (B12-BD). This domain binds different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide, it is found in several enzymes, such as glutamate mutase, methionine synthase...; Region: B12-binding; cd02067 246197012153 B12 binding site [chemical binding]; other site 246197012154 cobalt ligand [ion binding]; other site 246197012155 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 246197012156 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 246197012157 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 246197012158 tetramer interface [polypeptide binding]; other site 246197012159 heme binding pocket [chemical binding]; other site 246197012160 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 246197012161 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 246197012162 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 246197012163 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 246197012164 NAD(P) binding site [chemical binding]; other site 246197012165 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 246197012166 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 246197012167 Fe-S cluster binding site [ion binding]; other site 246197012168 active site 246197012169 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 246197012170 CoenzymeA binding site [chemical binding]; other site 246197012171 subunit interaction site [polypeptide binding]; other site 246197012172 PHB binding site; other site 246197012173 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 246197012174 Flavoprotein; Region: Flavoprotein; pfam02441 246197012175 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 246197012176 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197012177 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197012178 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197012179 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197012180 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197012181 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197012182 Protein phosphatase 2C; Region: PP2C; pfam00481 246197012183 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 246197012184 active site 246197012185 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 246197012186 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 246197012187 ligand binding site [chemical binding]; other site 246197012188 flexible hinge region; other site 246197012189 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 246197012190 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246197012191 phosphopeptide binding site; other site 246197012192 Amidinotransferase; Region: Amidinotransf; cl12043 246197012193 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 246197012194 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 246197012195 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246197012196 active site 246197012197 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 246197012198 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197012199 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 246197012200 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 246197012201 inhibitor-cofactor binding pocket; inhibition site 246197012202 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246197012203 catalytic residue [active] 246197012204 Condensation domain; Region: Condensation; pfam00668 246197012205 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197012206 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197012207 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246197012208 acyl-activating enzyme (AAE) consensus motif; other site 246197012209 AMP binding site [chemical binding]; other site 246197012210 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197012211 H+ Antiporter protein; Region: 2A0121; TIGR00900 246197012212 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 246197012213 acyl-CoA synthetase; Validated; Region: PRK05850 246197012214 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 246197012215 acyl-activating enzyme (AAE) consensus motif; other site 246197012216 active site 246197012217 hypothetical protein; Provisional; Region: PRK02237 246197012218 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 246197012219 Cupin-like domain; Region: Cupin_8; pfam13621 246197012220 Cephalosporin hydroxylase; Region: CmcI; pfam04989 246197012221 Cupin-like domain; Region: Cupin_8; pfam13621 246197012222 Methyltransferase domain; Region: Methyltransf_31; pfam13847 246197012223 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197012224 S-adenosylmethionine binding site [chemical binding]; other site 246197012225 acyl-CoA synthetase; Validated; Region: PRK05850 246197012226 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 246197012227 acyl-activating enzyme (AAE) consensus motif; other site 246197012228 active site 246197012229 Condensation domain; Region: Condensation; pfam00668 246197012230 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197012231 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197012232 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246197012233 acyl-activating enzyme (AAE) consensus motif; other site 246197012234 AMP binding site [chemical binding]; other site 246197012235 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197012236 Condensation domain; Region: Condensation; pfam00668 246197012237 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197012238 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197012239 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 246197012240 acyl-activating enzyme (AAE) consensus motif; other site 246197012241 AMP binding site [chemical binding]; other site 246197012242 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197012243 Condensation domain; Region: Condensation; pfam00668 246197012244 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246197012245 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 246197012246 acyl-activating enzyme (AAE) consensus motif; other site 246197012247 AMP binding site [chemical binding]; other site 246197012248 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197012249 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246197012250 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 246197012251 active site 246197012252 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 246197012253 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 246197012254 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197012255 Condensation domain; Region: Condensation; pfam00668 246197012256 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197012257 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197012258 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246197012259 acyl-activating enzyme (AAE) consensus motif; other site 246197012260 AMP binding site [chemical binding]; other site 246197012261 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197012262 Condensation domain; Region: Condensation; pfam00668 246197012263 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 246197012264 Cephalosporin hydroxylase; Region: CmcI; pfam04989 246197012265 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 246197012266 Transmembrane secretion effector; Region: MFS_3; pfam05977 246197012267 Aspartyl/Asparaginyl beta-hydroxylase; Region: Asp_Arg_Hydrox; cl17820 246197012268 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 246197012269 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 246197012270 active site 246197012271 Predicted membrane protein [Function unknown]; Region: COG2119 246197012272 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 246197012273 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 246197012274 Ribbon-helix-helix domain; Region: RHH_3; pfam12651 246197012275 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 246197012276 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 246197012277 Domain of unknown function (DUF329); Region: DUF329; pfam03884 246197012278 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 246197012279 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 246197012280 NAD(P) binding site [chemical binding]; other site 246197012281 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 246197012282 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 246197012283 agmatinase; Region: agmatinase; TIGR01230 246197012284 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 246197012285 putative active site [active] 246197012286 Mn binding site [ion binding]; other site 246197012287 Response regulator receiver domain; Region: Response_reg; pfam00072 246197012288 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197012289 active site 246197012290 phosphorylation site [posttranslational modification] 246197012291 intermolecular recognition site; other site 246197012292 dimerization interface [polypeptide binding]; other site 246197012293 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197012294 Protein of unknown function (DUF1342); Region: DUF1342; cl01892 246197012295 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197012296 ATP binding site [chemical binding]; other site 246197012297 Mg2+ binding site [ion binding]; other site 246197012298 G-X-G motif; other site 246197012299 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 246197012300 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 246197012301 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 246197012302 protein binding site [polypeptide binding]; other site 246197012303 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 246197012304 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 246197012305 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246197012306 active site 246197012307 ATP binding site [chemical binding]; other site 246197012308 substrate binding site [chemical binding]; other site 246197012309 activation loop (A-loop); other site 246197012310 PEGA domain; Region: PEGA; pfam08308 246197012311 PEGA domain; Region: PEGA; pfam08308 246197012312 Uncharacterized conserved protein [Function unknown]; Region: COG3268 246197012313 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 246197012314 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 246197012315 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 246197012316 active site 246197012317 Response regulator receiver domain; Region: Response_reg; pfam00072 246197012318 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197012319 active site 246197012320 phosphorylation site [posttranslational modification] 246197012321 intermolecular recognition site; other site 246197012322 dimerization interface [polypeptide binding]; other site 246197012323 cell surface protein SprA; Region: surface_SprA; TIGR04189 246197012324 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 246197012325 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 246197012326 FecR protein; Region: FecR; pfam04773 246197012327 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246197012328 dimerization interface [polypeptide binding]; other site 246197012329 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197012330 phosphorylation site [posttranslational modification] 246197012331 dimer interface [polypeptide binding]; other site 246197012332 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197012333 ATP binding site [chemical binding]; other site 246197012334 Mg2+ binding site [ion binding]; other site 246197012335 G-X-G motif; other site 246197012336 Response regulator receiver domain; Region: Response_reg; pfam00072 246197012337 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197012338 active site 246197012339 phosphorylation site [posttranslational modification] 246197012340 intermolecular recognition site; other site 246197012341 dimerization interface [polypeptide binding]; other site 246197012342 GAF domain; Region: GAF_3; pfam13492 246197012343 GAF domain; Region: GAF_2; pfam13185 246197012344 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 246197012345 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197012346 dimer interface [polypeptide binding]; other site 246197012347 phosphorylation site [posttranslational modification] 246197012348 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197012349 ATP binding site [chemical binding]; other site 246197012350 Mg2+ binding site [ion binding]; other site 246197012351 G-X-G motif; other site 246197012352 Response regulator receiver domain; Region: Response_reg; pfam00072 246197012353 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197012354 active site 246197012355 phosphorylation site [posttranslational modification] 246197012356 intermolecular recognition site; other site 246197012357 dimerization interface [polypeptide binding]; other site 246197012358 Response regulator receiver domain; Region: Response_reg; pfam00072 246197012359 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197012360 active site 246197012361 phosphorylation site [posttranslational modification] 246197012362 intermolecular recognition site; other site 246197012363 dimerization interface [polypeptide binding]; other site 246197012364 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 246197012365 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 246197012366 metal binding site [ion binding]; metal-binding site 246197012367 active site 246197012368 I-site; other site 246197012369 LexA repressor; Validated; Region: PRK00215 246197012370 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 246197012371 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 246197012372 Catalytic site [active] 246197012373 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 246197012374 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197012375 TPR motif; other site 246197012376 binding surface 246197012377 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 246197012378 binding surface 246197012379 TPR motif; other site 246197012380 TPR repeat; Region: TPR_11; pfam13414 246197012381 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197012382 TPR motif; other site 246197012383 binding surface 246197012384 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 246197012385 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 246197012386 Peptidase family M23; Region: Peptidase_M23; pfam01551 246197012387 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 246197012388 enolase; Provisional; Region: eno; PRK00077 246197012389 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 246197012390 dimer interface [polypeptide binding]; other site 246197012391 metal binding site [ion binding]; metal-binding site 246197012392 substrate binding pocket [chemical binding]; other site 246197012393 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 246197012394 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 246197012395 hydrophobic ligand binding site; other site 246197012396 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 246197012397 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 246197012398 putative active site [active] 246197012399 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 246197012400 active site 246197012401 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 246197012402 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 246197012403 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 246197012404 dimerization interface [polypeptide binding]; other site 246197012405 active site 246197012406 valyl-tRNA synthetase; Provisional; Region: valS; PRK14900 246197012407 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 246197012408 HIGH motif; other site 246197012409 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 246197012410 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 246197012411 active site 246197012412 KMSKS motif; other site 246197012413 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 246197012414 tRNA binding surface [nucleotide binding]; other site 246197012415 anticodon binding site; other site 246197012416 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 246197012417 Response regulator receiver domain; Region: Response_reg; pfam00072 246197012418 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197012419 active site 246197012420 phosphorylation site [posttranslational modification] 246197012421 intermolecular recognition site; other site 246197012422 dimerization interface [polypeptide binding]; other site 246197012423 CheW-like domain; Region: CheW; pfam01584 246197012424 Response regulator receiver domain; Region: Response_reg; pfam00072 246197012425 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197012426 active site 246197012427 phosphorylation site [posttranslational modification] 246197012428 intermolecular recognition site; other site 246197012429 dimerization interface [polypeptide binding]; other site 246197012430 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 246197012431 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 246197012432 metal binding site [ion binding]; metal-binding site 246197012433 active site 246197012434 I-site; other site 246197012435 Uncharacterized conserved protein [Function unknown]; Region: COG3461 246197012436 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197012437 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197012438 dimer interface [polypeptide binding]; other site 246197012439 phosphorylation site [posttranslational modification] 246197012440 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197012441 ATP binding site [chemical binding]; other site 246197012442 Mg2+ binding site [ion binding]; other site 246197012443 G-X-G motif; other site 246197012444 Response regulator receiver domain; Region: Response_reg; pfam00072 246197012445 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197012446 active site 246197012447 phosphorylation site [posttranslational modification] 246197012448 intermolecular recognition site; other site 246197012449 dimerization interface [polypeptide binding]; other site 246197012450 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 246197012451 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 246197012452 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 246197012453 ring oligomerisation interface [polypeptide binding]; other site 246197012454 ATP/Mg binding site [chemical binding]; other site 246197012455 stacking interactions; other site 246197012456 hinge regions; other site 246197012457 Response regulator receiver domain; Region: Response_reg; pfam00072 246197012458 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197012459 active site 246197012460 phosphorylation site [posttranslational modification] 246197012461 intermolecular recognition site; other site 246197012462 dimerization interface [polypeptide binding]; other site 246197012463 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197012464 TPR motif; other site 246197012465 binding surface 246197012466 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197012467 binding surface 246197012468 TPR motif; other site 246197012469 TPR repeat; Region: TPR_11; pfam13414 246197012470 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 246197012471 atypical (a) SDRs, subgroup 3; Region: SDR_a3; cd05229 246197012472 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 246197012473 putative NAD(P) binding site [chemical binding]; other site 246197012474 putative active site [active] 246197012475 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246197012476 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246197012477 WHG domain; Region: WHG; pfam13305 246197012478 putative transposase OrfB; Reviewed; Region: PHA02517 246197012479 HTH-like domain; Region: HTH_21; pfam13276 246197012480 Integrase core domain; Region: rve; pfam00665 246197012481 Integrase core domain; Region: rve_3; pfam13683 246197012482 DEAD-like helicases superfamily; Region: DEXDc; smart00487 246197012483 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246197012484 ATP binding site [chemical binding]; other site 246197012485 putative Mg++ binding site [ion binding]; other site 246197012486 helicase superfamily c-terminal domain; Region: HELICc; smart00490 246197012487 nucleotide binding region [chemical binding]; other site 246197012488 ATP-binding site [chemical binding]; other site 246197012489 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197012490 active site 246197012491 ATP binding site [chemical binding]; other site 246197012492 substrate binding site [chemical binding]; other site 246197012493 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197012494 activation loop (A-loop); other site 246197012495 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 246197012496 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246197012497 non-specific DNA binding site [nucleotide binding]; other site 246197012498 salt bridge; other site 246197012499 sequence-specific DNA binding site [nucleotide binding]; other site 246197012500 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 246197012501 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246197012502 non-specific DNA binding site [nucleotide binding]; other site 246197012503 salt bridge; other site 246197012504 sequence-specific DNA binding site [nucleotide binding]; other site 246197012505 Protein kinase domain; Region: Pkinase; pfam00069 246197012506 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197012507 active site 246197012508 ATP binding site [chemical binding]; other site 246197012509 substrate binding site [chemical binding]; other site 246197012510 activation loop (A-loop); other site 246197012511 Myxococcus xanthus paralogous family TIGR02268; Region: TIGR02268 246197012512 Domain of unknown function (DUF2019); Region: DUF2019; pfam09450 246197012513 DUSAM domain; Region: TIGR02267 246197012514 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 246197012515 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 246197012516 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 246197012517 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 246197012518 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 246197012519 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 246197012520 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 246197012521 Phage tail sheath protein FI [General function prediction only]; Region: COG3497 246197012522 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 246197012523 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; pfam06841 246197012524 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 246197012525 Gene 25-like lysozyme; Region: GPW_gp25; pfam04965 246197012526 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 246197012527 phage tail protein domain; Region: tail_TIGR02242 246197012528 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 246197012529 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197012530 Walker A motif; other site 246197012531 ATP binding site [chemical binding]; other site 246197012532 Walker B motif; other site 246197012533 arginine finger; other site 246197012534 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 246197012535 RibD C-terminal domain; Region: RibD_C; cl17279 246197012536 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246197012537 Walker A/P-loop; other site 246197012538 ATP binding site [chemical binding]; other site 246197012539 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 246197012540 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 246197012541 active site 246197012542 metal binding site [ion binding]; metal-binding site 246197012543 DNA binding site [nucleotide binding] 246197012544 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246197012545 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 246197012546 DNA binding residues [nucleotide binding] 246197012547 dimerization interface [polypeptide binding]; other site 246197012548 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 246197012549 Sulfatase; Region: Sulfatase; cl17466 246197012550 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246197012551 Q-loop/lid; other site 246197012552 Condensation domain; Region: Condensation; pfam00668 246197012553 L-aminoadipate-semialdehyde dehydrogenase; Region: alpha_am_amid; TIGR03443 246197012554 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197012555 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Saframycin A gene cluster from Streptomyces lavendulae; Region: A_NRPS_Sfm_like; cd12115 246197012556 acyl-activating enzyme (AAE) consensus motif; other site 246197012557 AMP binding site [chemical binding]; other site 246197012558 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197012559 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 246197012560 putative NAD(P) binding site [chemical binding]; other site 246197012561 active site 246197012562 putative substrate binding site [chemical binding]; other site 246197012563 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 246197012564 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246197012565 active site 246197012566 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 246197012567 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 246197012568 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246197012569 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 246197012570 NAD(P) binding site [chemical binding]; other site 246197012571 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 246197012572 KR domain; Region: KR; pfam08659 246197012573 putative NADP binding site [chemical binding]; other site 246197012574 active site 246197012575 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 246197012576 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 246197012577 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246197012578 active site 246197012579 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 246197012580 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 246197012581 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 246197012582 KR domain; Region: KR; pfam08659 246197012583 putative NADP binding site [chemical binding]; other site 246197012584 active site 246197012585 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 246197012586 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246197012587 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 246197012588 active site 246197012589 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 246197012590 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 246197012591 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 246197012592 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 246197012593 putative NADP binding site [chemical binding]; other site 246197012594 active site 246197012595 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 246197012596 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246197012597 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 246197012598 active site 246197012599 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 246197012600 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 246197012601 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 246197012602 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 246197012603 putative NADP binding site [chemical binding]; other site 246197012604 KR domain; Region: KR; pfam08659 246197012605 active site 246197012606 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 246197012607 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 246197012608 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246197012609 active site 246197012610 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 246197012611 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 246197012612 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 246197012613 KR domain; Region: KR; pfam08659 246197012614 putative NADP binding site [chemical binding]; other site 246197012615 active site 246197012616 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 246197012617 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 246197012618 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246197012619 active site 246197012620 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 246197012621 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 246197012622 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 246197012623 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 246197012624 putative NADP binding site [chemical binding]; other site 246197012625 active site 246197012626 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 246197012627 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 246197012628 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 246197012629 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 246197012630 active site 246197012631 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 246197012632 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 246197012633 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 246197012634 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 246197012635 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 246197012636 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 246197012637 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 246197012638 putative NADP binding site [chemical binding]; other site 246197012639 active site 246197012640 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 246197012641 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 246197012642 acyl-CoA synthetase; Validated; Region: PRK05850 246197012643 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 246197012644 acyl-activating enzyme (AAE) consensus motif; other site 246197012645 active site 246197012646 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 246197012647 Condensation domain; Region: Condensation; pfam00668 246197012648 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197012649 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197012650 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246197012651 acyl-activating enzyme (AAE) consensus motif; other site 246197012652 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 246197012653 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 246197012654 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246197012655 AMP binding site [chemical binding]; other site 246197012656 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197012657 H+ Antiporter protein; Region: 2A0121; TIGR00900 246197012658 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246197012659 putative substrate translocation pore; other site 246197012660 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 246197012661 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 246197012662 putative sugar binding sites [chemical binding]; other site 246197012663 Q-X-W motif; other site 246197012664 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 246197012665 putative sugar binding site [chemical binding]; other site 246197012666 catalytic residues [active] 246197012667 Domain of unknown function (DUF955); Region: DUF955; cl01076 246197012668 HerA helicase [Replication, recombination, and repair]; Region: COG0433 246197012669 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 246197012670 putative catalytic site [active] 246197012671 putative metal binding site [ion binding]; other site 246197012672 putative phosphate binding site [ion binding]; other site 246197012673 YceI-like domain; Region: YceI; smart00867 246197012674 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 246197012675 B12 binding site [chemical binding]; other site 246197012676 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 246197012677 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246197012678 FeS/SAM binding site; other site 246197012679 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 246197012680 cyclase homology domain; Region: CHD; cd07302 246197012681 nucleotidyl binding site; other site 246197012682 metal binding site [ion binding]; metal-binding site 246197012683 dimer interface [polypeptide binding]; other site 246197012684 cyclase homology domain; Region: CHD; cd07302 246197012685 nucleotidyl binding site; other site 246197012686 metal binding site [ion binding]; metal-binding site 246197012687 dimer interface [polypeptide binding]; other site 246197012688 AAA ATPase domain; Region: AAA_16; pfam13191 246197012689 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197012690 TPR motif; other site 246197012691 TPR repeat; Region: TPR_11; pfam13414 246197012692 binding surface 246197012693 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 246197012694 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 246197012695 hydroxyglutarate oxidase; Provisional; Region: PRK11728 246197012696 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 246197012697 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 246197012698 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 246197012699 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197012700 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197012701 active site 246197012702 ATP binding site [chemical binding]; other site 246197012703 substrate binding site [chemical binding]; other site 246197012704 activation loop (A-loop); other site 246197012705 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 246197012706 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 246197012707 N-terminal plug; other site 246197012708 ligand-binding site [chemical binding]; other site 246197012709 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197012710 TPR motif; other site 246197012711 binding surface 246197012712 TPR repeat; Region: TPR_11; pfam13414 246197012713 TPR repeat; Region: TPR_11; pfam13414 246197012714 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197012715 binding surface 246197012716 TPR motif; other site 246197012717 HAMP domain; Region: HAMP; pfam00672 246197012718 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 246197012719 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 246197012720 Peptidase family M50; Region: Peptidase_M50; pfam02163 246197012721 active site 246197012722 putative substrate binding region [chemical binding]; other site 246197012723 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 246197012724 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 246197012725 tetramer interface [polypeptide binding]; other site 246197012726 TPP-binding site [chemical binding]; other site 246197012727 heterodimer interface [polypeptide binding]; other site 246197012728 phosphorylation loop region [posttranslational modification] 246197012729 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 246197012730 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 246197012731 PYR/PP interface [polypeptide binding]; other site 246197012732 dimer interface [polypeptide binding]; other site 246197012733 TPP binding site [chemical binding]; other site 246197012734 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 246197012735 putative acetyltransferase; Provisional; Region: PRK03624 246197012736 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246197012737 Coenzyme A binding pocket [chemical binding]; other site 246197012738 Myxococcus xanthus paralogous domain TIGR02266; Region: gmx_TIGR02266 246197012739 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 246197012740 active site 246197012741 catalytic triad [active] 246197012742 oxyanion hole [active] 246197012743 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 246197012744 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 246197012745 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246197012746 ATP binding site [chemical binding]; other site 246197012747 putative Mg++ binding site [ion binding]; other site 246197012748 helicase superfamily c-terminal domain; Region: HELICc; smart00490 246197012749 nucleotide binding region [chemical binding]; other site 246197012750 ATP-binding site [chemical binding]; other site 246197012751 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 246197012752 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 246197012753 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 246197012754 CoA binding domain; Region: CoA_binding_2; pfam13380 246197012755 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 246197012756 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 246197012757 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 246197012758 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 246197012759 Myxococcales-restricted protein, TIGR02265 family; Region: Mxa_TIGR02265 246197012760 Protein of unknown function (DUF3014); Region: DUF3014; pfam11219 246197012761 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 246197012762 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197012763 dimer interface [polypeptide binding]; other site 246197012764 phosphorylation site [posttranslational modification] 246197012765 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197012766 ATP binding site [chemical binding]; other site 246197012767 Mg2+ binding site [ion binding]; other site 246197012768 G-X-G motif; other site 246197012769 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 246197012770 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197012771 active site 246197012772 phosphorylation site [posttranslational modification] 246197012773 intermolecular recognition site; other site 246197012774 dimerization interface [polypeptide binding]; other site 246197012775 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197012776 Walker A motif; other site 246197012777 ATP binding site [chemical binding]; other site 246197012778 Walker B motif; other site 246197012779 arginine finger; other site 246197012780 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 246197012781 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 246197012782 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 246197012783 ligand binding site [chemical binding]; other site 246197012784 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 246197012785 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246197012786 S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_30; cl17711 246197012787 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 246197012788 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 246197012789 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 246197012790 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 246197012791 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246197012792 Walker A/P-loop; other site 246197012793 ATP binding site [chemical binding]; other site 246197012794 Q-loop/lid; other site 246197012795 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 246197012796 ABC transporter signature motif; other site 246197012797 Walker B; other site 246197012798 D-loop; other site 246197012799 ABC transporter; Region: ABC_tran_2; pfam12848 246197012800 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 246197012801 Fn3 associated; Region: Fn3_assoc; pfam13287 246197012802 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 246197012803 Fn3 associated; Region: Fn3_assoc; pfam13287 246197012804 Fn3 associated; Region: Fn3_assoc; pfam13287 246197012805 Fn3 associated; Region: Fn3_assoc; pfam13287 246197012806 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 246197012807 PEGA domain; Region: PEGA; pfam08308 246197012808 PEGA domain; Region: PEGA; pfam08308 246197012809 Tetratricopeptide repeat; Region: TPR_16; pfam13432 246197012810 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246197012811 Protein kinase domain; Region: Pkinase; pfam00069 246197012812 active site 246197012813 ATP binding site [chemical binding]; other site 246197012814 substrate binding site [chemical binding]; other site 246197012815 activation loop (A-loop); other site 246197012816 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246197012817 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 246197012818 acyl-activating enzyme (AAE) consensus motif; other site 246197012819 AMP binding site [chemical binding]; other site 246197012820 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197012821 Condensation domain; Region: Condensation; pfam00668 246197012822 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197012823 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 246197012824 acyl-activating enzyme (AAE) consensus motif; other site 246197012825 AMP binding site [chemical binding]; other site 246197012826 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197012827 thioester reductase domain; Region: Thioester-redct; TIGR01746 246197012828 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 246197012829 putative NAD(P) binding site [chemical binding]; other site 246197012830 active site 246197012831 putative substrate binding site [chemical binding]; other site 246197012832 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 246197012833 Glycine/serine hydroxymethyltransferase [Amino acid transport and metabolism]; Region: GlyA; COG0112 246197012834 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246197012835 catalytic residue [active] 246197012836 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 246197012837 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246197012838 Coenzyme A binding pocket [chemical binding]; other site 246197012839 Condensation domain; Region: Condensation; pfam00668 246197012840 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197012841 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246197012842 acyl-activating enzyme (AAE) consensus motif; other site 246197012843 AMP binding site [chemical binding]; other site 246197012844 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197012845 Condensation domain; Region: Condensation; pfam00668 246197012846 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197012847 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197012848 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246197012849 acyl-activating enzyme (AAE) consensus motif; other site 246197012850 AMP binding site [chemical binding]; other site 246197012851 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197012852 Condensation domain; Region: Condensation; pfam00668 246197012853 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 246197012854 Condensation domain; Region: Condensation; pfam00668 246197012855 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197012856 B12 binding domain; Region: B12-binding; pfam02310 246197012857 B12 binding site [chemical binding]; other site 246197012858 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 246197012859 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246197012860 FeS/SAM binding site; other site 246197012861 Condensation domain; Region: Condensation; pfam00668 246197012862 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246197012863 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 246197012864 acyl-activating enzyme (AAE) consensus motif; other site 246197012865 AMP binding site [chemical binding]; other site 246197012866 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197012867 Condensation domain; Region: Condensation; pfam00668 246197012868 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 246197012869 M28 Zn-peptidase Endoplasmic reticulum metallopeptidase 1; Region: M28_Fxna_like; cd03875 246197012870 Peptidase family M28; Region: Peptidase_M28; pfam04389 246197012871 metal binding site [ion binding]; metal-binding site 246197012872 bacteriocin maturation radical SAM protein 1; Region: rSAM_ocin_1; TIGR03975 246197012873 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 246197012874 B12 binding site [chemical binding]; other site 246197012875 acyl-CoA synthetase; Validated; Region: PRK05850 246197012876 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 246197012877 acyl-activating enzyme (AAE) consensus motif; other site 246197012878 active site 246197012879 Condensation domain; Region: Condensation; pfam00668 246197012880 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197012881 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 246197012882 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 246197012883 acyl-activating enzyme (AAE) consensus motif; other site 246197012884 AMP binding site [chemical binding]; other site 246197012885 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197012886 Condensation domain; Region: Condensation; pfam00668 246197012887 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197012888 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197012889 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 246197012890 acyl-activating enzyme (AAE) consensus motif; other site 246197012891 AMP binding site [chemical binding]; other site 246197012892 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 246197012893 Condensation domain; Region: Condensation; pfam00668 246197012894 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 246197012895 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 246197012896 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 246197012897 B12 binding site [chemical binding]; other site 246197012898 Radical SAM superfamily; Region: Radical_SAM; pfam04055 246197012899 Cupin-like domain; Region: Cupin_8; pfam13621 246197012900 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246197012901 putative substrate translocation pore; other site 246197012902 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 246197012903 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 246197012904 putative hydrophobic ligand binding site [chemical binding]; other site 246197012905 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246197012906 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246197012907 putative substrate translocation pore; other site 246197012908 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246197012909 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 246197012910 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 246197012911 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 246197012912 substrate binding site; other site 246197012913 tetramer interface; other site 246197012914 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 246197012915 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 246197012916 NADP binding site [chemical binding]; other site 246197012917 active site 246197012918 putative substrate binding site [chemical binding]; other site 246197012919 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 246197012920 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 246197012921 NAD binding site [chemical binding]; other site 246197012922 substrate binding site [chemical binding]; other site 246197012923 homodimer interface [polypeptide binding]; other site 246197012924 active site 246197012925 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246197012926 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 246197012927 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 246197012928 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246197012929 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 246197012930 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 246197012931 active site 246197012932 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 246197012933 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 246197012934 Ligand binding site; other site 246197012935 Putative Catalytic site; other site 246197012936 DXD motif; other site 246197012937 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246197012938 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 246197012939 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 246197012940 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 246197012941 active site 246197012942 Methyltransferase domain; Region: Methyltransf_31; pfam13847 246197012943 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197012944 S-adenosylmethionine binding site [chemical binding]; other site 246197012945 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 246197012946 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 246197012947 Probable Catalytic site; other site 246197012948 metal-binding site 246197012949 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 246197012950 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 246197012951 Probable Catalytic site; other site 246197012952 metal-binding site 246197012953 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 246197012954 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246197012955 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 246197012956 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 246197012957 Walker A/P-loop; other site 246197012958 ATP binding site [chemical binding]; other site 246197012959 Q-loop/lid; other site 246197012960 ABC transporter signature motif; other site 246197012961 Walker B; other site 246197012962 D-loop; other site 246197012963 H-loop/switch region; other site 246197012964 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 246197012965 putative carbohydrate binding site [chemical binding]; other site 246197012966 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 246197012967 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 246197012968 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 246197012969 TPR repeat; Region: TPR_11; pfam13414 246197012970 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197012971 binding surface 246197012972 TPR motif; other site 246197012973 TPR repeat; Region: TPR_11; pfam13414 246197012974 TPR repeat; Region: TPR_11; pfam13414 246197012975 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 246197012976 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 246197012977 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 246197012978 N-acetyl-D-glucosamine binding site [chemical binding]; other site 246197012979 catalytic residue [active] 246197012980 L-aspartate oxidase; Provisional; Region: PRK09077 246197012981 L-aspartate oxidase; Provisional; Region: PRK06175 246197012982 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 246197012983 Rhomboid family; Region: Rhomboid; pfam01694 246197012984 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 246197012985 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 246197012986 active site 246197012987 ParB-like nuclease domain; Region: ParBc; pfam02195 246197012988 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 246197012989 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 246197012990 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 246197012991 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 246197012992 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 246197012993 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 246197012994 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 246197012995 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197012996 binding surface 246197012997 TPR motif; other site 246197012998 TPR repeat; Region: TPR_11; pfam13414 246197012999 Tetratricopeptide repeat; Region: TPR_16; pfam13432 246197013000 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197013001 TPR motif; other site 246197013002 binding surface 246197013003 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197013004 binding surface 246197013005 TPR motif; other site 246197013006 Tetratricopeptide repeat; Region: TPR_12; pfam13424 246197013007 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 246197013008 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 246197013009 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197013010 dimer interface [polypeptide binding]; other site 246197013011 phosphorylation site [posttranslational modification] 246197013012 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197013013 ATP binding site [chemical binding]; other site 246197013014 Mg2+ binding site [ion binding]; other site 246197013015 G-X-G motif; other site 246197013016 Response regulator receiver domain; Region: Response_reg; pfam00072 246197013017 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197013018 active site 246197013019 phosphorylation site [posttranslational modification] 246197013020 intermolecular recognition site; other site 246197013021 dimerization interface [polypeptide binding]; other site 246197013022 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 246197013023 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 246197013024 metal binding site [ion binding]; metal-binding site 246197013025 active site 246197013026 I-site; other site 246197013027 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 246197013028 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 246197013029 RNA binding surface [nucleotide binding]; other site 246197013030 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 246197013031 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 246197013032 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 246197013033 TPP-binding site; other site 246197013034 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 246197013035 PYR/PP interface [polypeptide binding]; other site 246197013036 dimer interface [polypeptide binding]; other site 246197013037 TPP binding site [chemical binding]; other site 246197013038 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 246197013039 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 246197013040 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 246197013041 substrate binding pocket [chemical binding]; other site 246197013042 chain length determination region; other site 246197013043 substrate-Mg2+ binding site; other site 246197013044 catalytic residues [active] 246197013045 aspartate-rich region 1; other site 246197013046 active site lid residues [active] 246197013047 aspartate-rich region 2; other site 246197013048 Response regulator receiver domain; Region: Response_reg; pfam00072 246197013049 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197013050 active site 246197013051 phosphorylation site [posttranslational modification] 246197013052 intermolecular recognition site; other site 246197013053 dimerization interface [polypeptide binding]; other site 246197013054 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 246197013055 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 246197013056 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 246197013057 generic binding surface II; other site 246197013058 generic binding surface I; other site 246197013059 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 246197013060 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246197013061 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 246197013062 phosphopeptide binding site; other site 246197013063 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 246197013064 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246197013065 phosphopeptide binding site; other site 246197013066 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 246197013067 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 246197013068 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 246197013069 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 246197013070 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 246197013071 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 246197013072 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 246197013073 TadE-like protein; Region: TadE; pfam07811 246197013074 TadE-like protein; Region: TadE; pfam07811 246197013075 Putative zinc-finger; Region: zf-HC2; pfam13490 246197013076 RNA polymerase sigma factor; Provisional; Region: PRK12513 246197013077 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246197013078 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246197013079 DNA binding residues [nucleotide binding] 246197013080 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 246197013081 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 246197013082 Walker A/P-loop; other site 246197013083 ATP binding site [chemical binding]; other site 246197013084 Q-loop/lid; other site 246197013085 ABC transporter signature motif; other site 246197013086 Walker B; other site 246197013087 D-loop; other site 246197013088 H-loop/switch region; other site 246197013089 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 246197013090 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 246197013091 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 246197013092 Walker A/P-loop; other site 246197013093 ATP binding site [chemical binding]; other site 246197013094 Q-loop/lid; other site 246197013095 ABC transporter signature motif; other site 246197013096 Walker B; other site 246197013097 D-loop; other site 246197013098 H-loop/switch region; other site 246197013099 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 246197013100 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 246197013101 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 246197013102 Domain of unknown function (DUF4292); Region: DUF4292; pfam14125 246197013103 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 246197013104 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 246197013105 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 246197013106 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246197013107 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246197013108 active site 246197013109 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 246197013110 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 246197013111 active site 246197013112 catalytic site [active] 246197013113 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 246197013114 active site 246197013115 catalytic site [active] 246197013116 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 246197013117 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 246197013118 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 246197013119 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197013120 active site 246197013121 phosphorylation site [posttranslational modification] 246197013122 intermolecular recognition site; other site 246197013123 dimerization interface [polypeptide binding]; other site 246197013124 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 246197013125 Zn2+ binding site [ion binding]; other site 246197013126 Mg2+ binding site [ion binding]; other site 246197013127 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 246197013128 active site 246197013129 MoxR-like ATPases [General function prediction only]; Region: COG0714 246197013130 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197013131 Walker A motif; other site 246197013132 ATP binding site [chemical binding]; other site 246197013133 Walker B motif; other site 246197013134 arginine finger; other site 246197013135 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 246197013136 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 246197013137 metal ion-dependent adhesion site (MIDAS); other site 246197013138 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246197013139 ATP binding site [chemical binding]; other site 246197013140 putative Mg++ binding site [ion binding]; other site 246197013141 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 246197013142 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246197013143 nucleotide binding region [chemical binding]; other site 246197013144 ATP-binding site [chemical binding]; other site 246197013145 Smr domain; Region: Smr; pfam01713 246197013146 Protein of unknown function DUF72; Region: DUF72; pfam01904 246197013147 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 246197013148 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 246197013149 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 246197013150 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 246197013151 dimer interface [polypeptide binding]; other site 246197013152 anticodon binding site; other site 246197013153 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 246197013154 homodimer interface [polypeptide binding]; other site 246197013155 motif 1; other site 246197013156 active site 246197013157 motif 2; other site 246197013158 GAD domain; Region: GAD; pfam02938 246197013159 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 246197013160 active site 246197013161 motif 3; other site 246197013162 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 246197013163 Zn binding site [ion binding]; other site 246197013164 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 246197013165 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 246197013166 DHH family; Region: DHH; pfam01368 246197013167 DHHA1 domain; Region: DHHA1; pfam02272 246197013168 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 246197013169 protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966 246197013170 Protein export membrane protein; Region: SecD_SecF; pfam02355 246197013171 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 246197013172 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 246197013173 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 246197013174 Preprotein translocase subunit; Region: YajC; pfam02699 246197013175 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 246197013176 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 246197013177 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 246197013178 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 246197013179 Stage II sporulation protein; Region: SpoIID; pfam08486 246197013180 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 246197013181 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 246197013182 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246197013183 FeS/SAM binding site; other site 246197013184 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 246197013185 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 246197013186 Radical SAM superfamily; Region: Radical_SAM; pfam04055 246197013187 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246197013188 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197013189 active site 246197013190 ATP binding site [chemical binding]; other site 246197013191 substrate binding site [chemical binding]; other site 246197013192 activation loop (A-loop); other site 246197013193 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 246197013194 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 246197013195 catalytic site [active] 246197013196 G-X2-G-X-G-K; other site 246197013197 hypothetical protein; Provisional; Region: PRK11820 246197013198 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 246197013199 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 246197013200 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 246197013201 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 246197013202 putative active site [active] 246197013203 Trm112p-like protein; Region: Trm112p; cl01066 246197013204 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 246197013205 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 246197013206 active site 246197013207 nucleotide binding site [chemical binding]; other site 246197013208 HIGH motif; other site 246197013209 KMSKS motif; other site 246197013210 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 246197013211 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 246197013212 substrate binding site [chemical binding]; other site 246197013213 ATP binding site [chemical binding]; other site 246197013214 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 246197013215 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 246197013216 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 246197013217 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246197013218 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 246197013219 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 246197013220 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 246197013221 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 246197013222 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 246197013223 active site 246197013224 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 246197013225 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 246197013226 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246197013227 Walker A/P-loop; other site 246197013228 ATP binding site [chemical binding]; other site 246197013229 Q-loop/lid; other site 246197013230 ABC transporter signature motif; other site 246197013231 Walker B; other site 246197013232 D-loop; other site 246197013233 H-loop/switch region; other site 246197013234 Response regulator receiver domain; Region: Response_reg; pfam00072 246197013235 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197013236 active site 246197013237 phosphorylation site [posttranslational modification] 246197013238 intermolecular recognition site; other site 246197013239 dimerization interface [polypeptide binding]; other site 246197013240 DnaJ domain; Region: DnaJ; pfam00226 246197013241 TPR repeat; Region: TPR_11; pfam13414 246197013242 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197013243 binding surface 246197013244 TPR motif; other site 246197013245 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 246197013246 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 246197013247 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 246197013248 Ligand binding site; other site 246197013249 Putative Catalytic site; other site 246197013250 DXD motif; other site 246197013251 MarC family integral membrane protein; Region: MarC; pfam01914 246197013252 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 246197013253 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 246197013254 ligand binding site [chemical binding]; other site 246197013255 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 246197013256 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 246197013257 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 246197013258 active site 246197013259 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 246197013260 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 246197013261 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 246197013262 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 246197013263 trimer interface [polypeptide binding]; other site 246197013264 active site 246197013265 UDP-GlcNAc binding site [chemical binding]; other site 246197013266 lipid binding site [chemical binding]; lipid-binding site 246197013267 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 246197013268 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 246197013269 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 246197013270 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 246197013271 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 246197013272 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 246197013273 Surface antigen; Region: Bac_surface_Ag; pfam01103 246197013274 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 246197013275 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 246197013276 Walker A/P-loop; other site 246197013277 ATP binding site [chemical binding]; other site 246197013278 Q-loop/lid; other site 246197013279 ABC transporter signature motif; other site 246197013280 Walker B; other site 246197013281 D-loop; other site 246197013282 H-loop/switch region; other site 246197013283 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 246197013284 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 246197013285 FtsX-like permease family; Region: FtsX; pfam02687 246197013286 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 246197013287 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 246197013288 dimer interface [polypeptide binding]; other site 246197013289 putative anticodon binding site; other site 246197013290 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 246197013291 motif 1; other site 246197013292 active site 246197013293 motif 2; other site 246197013294 motif 3; other site 246197013295 Putative zinc-finger; Region: zf-HC2; pfam13490 246197013296 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 246197013297 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246197013298 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246197013299 DNA binding residues [nucleotide binding] 246197013300 peptide chain release factor 2; Validated; Region: prfB; PRK00578 246197013301 This domain is found in peptide chain release factors; Region: PCRF; smart00937 246197013302 RF-1 domain; Region: RF-1; pfam00472 246197013303 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 246197013304 Cupin domain; Region: Cupin_2; pfam07883 246197013305 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 246197013306 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 246197013307 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 246197013308 Zn2+ binding site [ion binding]; other site 246197013309 Mg2+ binding site [ion binding]; other site 246197013310 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 246197013311 PhoH-like protein; Region: PhoH; pfam02562 246197013312 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 246197013313 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 246197013314 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197013315 binding surface 246197013316 TPR motif; other site 246197013317 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 246197013318 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 246197013319 homodimer interface [polypeptide binding]; other site 246197013320 metal binding site [ion binding]; metal-binding site 246197013321 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 246197013322 homodimer interface [polypeptide binding]; other site 246197013323 active site 246197013324 putative chemical substrate binding site [chemical binding]; other site 246197013325 metal binding site [ion binding]; metal-binding site 246197013326 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 246197013327 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 246197013328 Lipopolysaccharide-assembly; Region: LptE; pfam04390 246197013329 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 246197013330 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 246197013331 HIGH motif; other site 246197013332 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 246197013333 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 246197013334 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 246197013335 active site 246197013336 KMSKS motif; other site 246197013337 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 246197013338 tRNA binding surface [nucleotide binding]; other site 246197013339 TonB-linked outer membrane protein, SusC/RagA family; Region: OMP_RagA_SusC; TIGR04056 246197013340 Cna protein B-type domain; Region: Cna_B_2; pfam13715 246197013341 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 246197013342 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 246197013343 starch binding outer membrane protein SusD; Region: SusD; cd08977 246197013344 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 246197013345 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 246197013346 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 246197013347 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 246197013348 Walker A/P-loop; other site 246197013349 ATP binding site [chemical binding]; other site 246197013350 Q-loop/lid; other site 246197013351 ABC transporter signature motif; other site 246197013352 Walker B; other site 246197013353 D-loop; other site 246197013354 H-loop/switch region; other site 246197013355 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197013356 Response regulator receiver domain; Region: Response_reg; pfam00072 246197013357 active site 246197013358 phosphorylation site [posttranslational modification] 246197013359 intermolecular recognition site; other site 246197013360 dimerization interface [polypeptide binding]; other site 246197013361 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 246197013362 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197013363 active site 246197013364 phosphorylation site [posttranslational modification] 246197013365 intermolecular recognition site; other site 246197013366 dimerization interface [polypeptide binding]; other site 246197013367 CheB methylesterase; Region: CheB_methylest; pfam01339 246197013368 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 246197013369 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 246197013370 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197013371 S-adenosylmethionine binding site [chemical binding]; other site 246197013372 HEAT repeats; Region: HEAT_2; pfam13646 246197013373 HEAT repeats; Region: HEAT_2; pfam13646 246197013374 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 246197013375 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 246197013376 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 246197013377 putative binding surface; other site 246197013378 active site 246197013379 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 246197013380 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 246197013381 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197013382 ATP binding site [chemical binding]; other site 246197013383 Mg2+ binding site [ion binding]; other site 246197013384 G-X-G motif; other site 246197013385 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 246197013386 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 246197013387 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197013388 active site 246197013389 phosphorylation site [posttranslational modification] 246197013390 intermolecular recognition site; other site 246197013391 dimerization interface [polypeptide binding]; other site 246197013392 Cytosol aminopeptidase family, N-terminal domain; Region: Peptidase_M17_N; pfam02789 246197013393 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 246197013394 putative RNA binding site [nucleotide binding]; other site 246197013395 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 246197013396 homopentamer interface [polypeptide binding]; other site 246197013397 active site 246197013398 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 246197013399 Lumazine binding domain; Region: Lum_binding; pfam00677 246197013400 Lumazine binding domain; Region: Lum_binding; pfam00677 246197013401 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 246197013402 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 246197013403 catalytic motif [active] 246197013404 Zn binding site [ion binding]; other site 246197013405 RibD C-terminal domain; Region: RibD_C; cl17279 246197013406 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 246197013407 ATP cone domain; Region: ATP-cone; pfam03477 246197013408 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 246197013409 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 246197013410 dimer interface [polypeptide binding]; other site 246197013411 active site 246197013412 glycine-pyridoxal phosphate binding site [chemical binding]; other site 246197013413 folate binding site [chemical binding]; other site 246197013414 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 246197013415 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 246197013416 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 246197013417 dimer interface [polypeptide binding]; other site 246197013418 active site 246197013419 acyl carrier protein; Provisional; Region: acpP; PRK00982 246197013420 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 246197013421 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 246197013422 NAD(P) binding site [chemical binding]; other site 246197013423 homotetramer interface [polypeptide binding]; other site 246197013424 homodimer interface [polypeptide binding]; other site 246197013425 active site 246197013426 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 246197013427 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 246197013428 putative phosphate acyltransferase; Provisional; Region: PRK05331 246197013429 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 246197013430 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 246197013431 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 246197013432 TPR motif; other site 246197013433 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 246197013434 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197013435 active site 246197013436 phosphorylation site [posttranslational modification] 246197013437 intermolecular recognition site; other site 246197013438 dimerization interface [polypeptide binding]; other site 246197013439 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 246197013440 DNA binding site [nucleotide binding] 246197013441 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 246197013442 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197013443 dimer interface [polypeptide binding]; other site 246197013444 phosphorylation site [posttranslational modification] 246197013445 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197013446 ATP binding site [chemical binding]; other site 246197013447 Mg2+ binding site [ion binding]; other site 246197013448 G-X-G motif; other site 246197013449 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 246197013450 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 246197013451 active site 246197013452 metal binding site [ion binding]; metal-binding site 246197013453 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 246197013454 catalytic core [active] 246197013455 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 246197013456 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 246197013457 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 246197013458 active site clefts [active] 246197013459 zinc binding site [ion binding]; other site 246197013460 dimer interface [polypeptide binding]; other site 246197013461 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 246197013462 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 246197013463 Sulfate transporter family; Region: Sulfate_transp; pfam00916 246197013464 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 246197013465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197013466 active site 246197013467 phosphorylation site [posttranslational modification] 246197013468 intermolecular recognition site; other site 246197013469 dimerization interface [polypeptide binding]; other site 246197013470 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197013471 Walker A motif; other site 246197013472 ATP binding site [chemical binding]; other site 246197013473 Walker B motif; other site 246197013474 arginine finger; other site 246197013475 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 246197013476 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197013477 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197013478 dimer interface [polypeptide binding]; other site 246197013479 phosphorylation site [posttranslational modification] 246197013480 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197013481 ATP binding site [chemical binding]; other site 246197013482 Mg2+ binding site [ion binding]; other site 246197013483 G-X-G motif; other site 246197013484 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 246197013485 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197013486 active site 246197013487 phosphorylation site [posttranslational modification] 246197013488 intermolecular recognition site; other site 246197013489 dimerization interface [polypeptide binding]; other site 246197013490 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 246197013491 DNA binding site [nucleotide binding] 246197013492 PBP superfamily domain; Region: PBP_like_2; cl17296 246197013493 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 246197013494 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 246197013495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246197013496 dimer interface [polypeptide binding]; other site 246197013497 conserved gate region; other site 246197013498 putative PBP binding loops; other site 246197013499 ABC-ATPase subunit interface; other site 246197013500 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 246197013501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246197013502 ABC-ATPase subunit interface; other site 246197013503 phosphate transporter ATP-binding protein; Provisional; Region: PRK14242 246197013504 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 246197013505 Walker A/P-loop; other site 246197013506 ATP binding site [chemical binding]; other site 246197013507 Q-loop/lid; other site 246197013508 ABC transporter signature motif; other site 246197013509 Walker B; other site 246197013510 D-loop; other site 246197013511 H-loop/switch region; other site 246197013512 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 246197013513 PhoU domain; Region: PhoU; pfam01895 246197013514 PhoU domain; Region: PhoU; pfam01895 246197013515 Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520 246197013516 ligand binding site; other site 246197013517 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 246197013518 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197013519 Response regulator receiver domain; Region: Response_reg; pfam00072 246197013520 active site 246197013521 phosphorylation site [posttranslational modification] 246197013522 intermolecular recognition site; other site 246197013523 dimerization interface [polypeptide binding]; other site 246197013524 Domain of unknown function DUF21; Region: DUF21; pfam01595 246197013525 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 246197013526 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 246197013527 Transporter associated domain; Region: CorC_HlyC; smart01091 246197013528 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 246197013529 Interdomain contacts; other site 246197013530 Cytokine receptor motif; other site 246197013531 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 246197013532 Interdomain contacts; other site 246197013533 Cytokine receptor motif; other site 246197013534 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 246197013535 Interdomain contacts; other site 246197013536 Cytokine receptor motif; other site 246197013537 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 246197013538 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 246197013539 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 246197013540 ligand binding site [chemical binding]; other site 246197013541 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 246197013542 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 246197013543 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 246197013544 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 246197013545 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 246197013546 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 246197013547 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 246197013548 type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349 246197013549 type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348 246197013550 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 246197013551 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 246197013552 type VI secretion-associated protein, BMA_A0400 family; Region: VI_minor_4; TIGR03373 246197013553 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 246197013554 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 246197013555 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 246197013556 Protein of unknown function (DUF770); Region: DUF770; pfam05591 246197013557 type VI secretion protein, EvpB/VC_A0108 family; Region: VI_chp_2; TIGR03355 246197013558 Protein of unknown function (DUF877); Region: DUF877; pfam05943 246197013559 Protein of unknown function (DUF796); Region: DUF796; pfam05638 246197013560 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 246197013561 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 246197013562 type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359 246197013563 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 246197013564 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 246197013565 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197013566 Walker A motif; other site 246197013567 ATP binding site [chemical binding]; other site 246197013568 Walker B motif; other site 246197013569 arginine finger; other site 246197013570 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197013571 Walker A motif; other site 246197013572 ATP binding site [chemical binding]; other site 246197013573 Walker B motif; other site 246197013574 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 246197013575 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 246197013576 30S subunit binding site; other site 246197013577 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 246197013578 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 246197013579 catalytic residues [active] 246197013580 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 246197013581 active site 246197013582 catalytic residues [active] 246197013583 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 246197013584 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 246197013585 Walker A/P-loop; other site 246197013586 ATP binding site [chemical binding]; other site 246197013587 Q-loop/lid; other site 246197013588 ABC transporter signature motif; other site 246197013589 Walker B; other site 246197013590 D-loop; other site 246197013591 H-loop/switch region; other site 246197013592 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 246197013593 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246197013594 dimer interface [polypeptide binding]; other site 246197013595 conserved gate region; other site 246197013596 putative PBP binding loops; other site 246197013597 ABC-ATPase subunit interface; other site 246197013598 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 246197013599 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246197013600 dimer interface [polypeptide binding]; other site 246197013601 conserved gate region; other site 246197013602 putative PBP binding loops; other site 246197013603 ABC-ATPase subunit interface; other site 246197013604 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 246197013605 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 246197013606 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197013607 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 246197013608 Walker A motif; other site 246197013609 ATP binding site [chemical binding]; other site 246197013610 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197013611 Walker A motif; other site 246197013612 ATP binding site [chemical binding]; other site 246197013613 Walker B motif; other site 246197013614 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 246197013615 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197013616 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 246197013617 Walker A motif; other site 246197013618 ATP binding site [chemical binding]; other site 246197013619 Walker B motif; other site 246197013620 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197013621 Walker A motif; other site 246197013622 ATP binding site [chemical binding]; other site 246197013623 Walker B motif; other site 246197013624 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 246197013625 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 246197013626 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197013627 Walker A motif; other site 246197013628 ATP binding site [chemical binding]; other site 246197013629 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197013630 Walker A motif; other site 246197013631 ATP binding site [chemical binding]; other site 246197013632 Walker B motif; other site 246197013633 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 246197013634 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 246197013635 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 246197013636 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 246197013637 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 246197013638 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 246197013639 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 246197013640 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 246197013641 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 246197013642 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 246197013643 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246197013644 catalytic loop [active] 246197013645 iron binding site [ion binding]; other site 246197013646 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 246197013647 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 246197013648 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197013649 Walker A motif; other site 246197013650 ATP binding site [chemical binding]; other site 246197013651 Walker B motif; other site 246197013652 arginine finger; other site 246197013653 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197013654 Walker A motif; other site 246197013655 ATP binding site [chemical binding]; other site 246197013656 Walker B motif; other site 246197013657 arginine finger; other site 246197013658 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 246197013659 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246197013660 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246197013661 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 246197013662 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 246197013663 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 246197013664 Amidase; Region: Amidase; cl11426 246197013665 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 246197013666 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246197013667 ATP binding site [chemical binding]; other site 246197013668 putative Mg++ binding site [ion binding]; other site 246197013669 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246197013670 nucleotide binding region [chemical binding]; other site 246197013671 ATP-binding site [chemical binding]; other site 246197013672 Pirin-related protein [General function prediction only]; Region: COG1741 246197013673 Pirin; Region: Pirin; pfam02678 246197013674 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 246197013675 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246197013676 active site 246197013677 ATP binding site [chemical binding]; other site 246197013678 substrate binding site [chemical binding]; other site 246197013679 activation loop (A-loop); other site 246197013680 Protein kinase domain; Region: Pkinase; pfam00069 246197013681 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197013682 active site 246197013683 ATP binding site [chemical binding]; other site 246197013684 substrate binding site [chemical binding]; other site 246197013685 activation loop (A-loop); other site 246197013686 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 246197013687 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 246197013688 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 246197013689 active site 246197013690 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 246197013691 Transposase; Region: HTH_Tnp_1; cl17663 246197013692 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 246197013693 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 246197013694 active site 246197013695 DNA binding site [nucleotide binding] 246197013696 Int/Topo IB signature motif; other site 246197013697 signal recognition particle protein; Provisional; Region: PRK10867 246197013698 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 246197013699 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 246197013700 P loop; other site 246197013701 GTP binding site [chemical binding]; other site 246197013702 Signal peptide binding domain; Region: SRP_SPB; pfam02978 246197013703 Bacterial Ig-like domain; Region: Big_5; pfam13205 246197013704 Bacterial Ig-like domain; Region: Big_5; pfam13205 246197013705 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 246197013706 MJ0042 family finger-like domain; Region: MJ0042_CXXC; TIGR02098 246197013707 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 246197013708 photosystem I assembly protein Ycf3; Provisional; Region: PRK02603 246197013709 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 246197013710 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197013711 binding surface 246197013712 TPR motif; other site 246197013713 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 246197013714 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197013715 TPR motif; other site 246197013716 binding surface 246197013717 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197013718 binding surface 246197013719 TPR motif; other site 246197013720 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197013721 binding surface 246197013722 TPR motif; other site 246197013723 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197013724 binding surface 246197013725 TPR motif; other site 246197013726 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 246197013727 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246197013728 phosphopeptide binding site; other site 246197013729 tol-pal system protein YbgF; Provisional; Region: PRK10803 246197013730 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197013731 binding surface 246197013732 TPR motif; other site 246197013733 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 246197013734 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197013735 TPR motif; other site 246197013736 binding surface 246197013737 TPR repeat; Region: TPR_11; pfam13414 246197013738 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197013739 binding surface 246197013740 TPR motif; other site 246197013741 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 246197013742 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197013743 binding surface 246197013744 TPR motif; other site 246197013745 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197013746 Walker A motif; other site 246197013747 ATP binding site [chemical binding]; other site 246197013748 Walker B motif; other site 246197013749 CutA1 divalent ion tolerance protein; Region: CutA1; pfam03091 246197013750 Strictosidine synthase; Region: Str_synth; pfam03088 246197013751 aspartate kinase; Reviewed; Region: PRK06635 246197013752 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 246197013753 putative catalytic residues [active] 246197013754 putative nucleotide binding site [chemical binding]; other site 246197013755 putative aspartate binding site [chemical binding]; other site 246197013756 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 246197013757 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 246197013758 Walker A/P-loop; other site 246197013759 ATP binding site [chemical binding]; other site 246197013760 Q-loop/lid; other site 246197013761 ABC transporter signature motif; other site 246197013762 Walker B; other site 246197013763 D-loop; other site 246197013764 H-loop/switch region; other site 246197013765 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 246197013766 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 246197013767 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 246197013768 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 246197013769 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 246197013770 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 246197013771 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 246197013772 active site 246197013773 metal binding site [ion binding]; metal-binding site 246197013774 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 246197013775 Domain of unknown function (DUF4384); Region: DUF4384; pfam14326 246197013776 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246197013777 muropeptide transporter; Reviewed; Region: ampG; PRK11902 246197013778 putative substrate translocation pore; other site 246197013779 phosphoglucomutase; Validated; Region: PRK07564 246197013780 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 246197013781 active site 246197013782 substrate binding site [chemical binding]; other site 246197013783 metal binding site [ion binding]; metal-binding site 246197013784 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 246197013785 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 246197013786 active site 246197013787 Ap6A binding site [chemical binding]; other site 246197013788 nudix motif; other site 246197013789 metal binding site [ion binding]; metal-binding site 246197013790 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 246197013791 oligomerisation interface [polypeptide binding]; other site 246197013792 mobile loop; other site 246197013793 roof hairpin; other site 246197013794 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 246197013795 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 246197013796 ring oligomerisation interface [polypeptide binding]; other site 246197013797 ATP/Mg binding site [chemical binding]; other site 246197013798 stacking interactions; other site 246197013799 hinge regions; other site 246197013800 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 246197013801 GSH binding site [chemical binding]; other site 246197013802 catalytic residues [active] 246197013803 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246197013804 phosphopeptide binding site; other site 246197013805 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 246197013806 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197013807 Walker A motif; other site 246197013808 ATP binding site [chemical binding]; other site 246197013809 Walker B motif; other site 246197013810 arginine finger; other site 246197013811 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 246197013812 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 246197013813 Walker A/P-loop; other site 246197013814 ATP binding site [chemical binding]; other site 246197013815 Q-loop/lid; other site 246197013816 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 246197013817 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 246197013818 ABC transporter signature motif; other site 246197013819 Walker B; other site 246197013820 D-loop; other site 246197013821 H-loop/switch region; other site 246197013822 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 246197013823 Domain of unknown function DUF21; Region: DUF21; pfam01595 246197013824 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 246197013825 Transporter associated domain; Region: CorC_HlyC; smart01091 246197013826 TPR repeat; Region: TPR_11; pfam13414 246197013827 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197013828 binding surface 246197013829 TPR motif; other site 246197013830 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197013831 binding surface 246197013832 TPR motif; other site 246197013833 TPR repeat; Region: TPR_11; pfam13414 246197013834 TPR repeat; Region: TPR_11; pfam13414 246197013835 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197013836 binding surface 246197013837 TPR motif; other site 246197013838 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197013839 binding surface 246197013840 TPR motif; other site 246197013841 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 246197013842 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 246197013843 putative active site [active] 246197013844 putative metal binding site [ion binding]; other site 246197013845 peptide chain release factor 1; Validated; Region: prfA; PRK00591 246197013846 PCRF domain; Region: PCRF; pfam03462 246197013847 RF-1 domain; Region: RF-1; pfam00472 246197013848 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 246197013849 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197013850 S-adenosylmethionine binding site [chemical binding]; other site 246197013851 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 246197013852 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 246197013853 hinge; other site 246197013854 active site 246197013855 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 246197013856 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 246197013857 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 246197013858 sugar binding site [chemical binding]; other site 246197013859 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 246197013860 sugar binding site [chemical binding]; other site 246197013861 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 246197013862 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 246197013863 Winged helix-turn helix; Region: HTH_29; pfam13551 246197013864 DDE superfamily endonuclease; Region: DDE_3; pfam13358 246197013865 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 246197013866 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246197013867 Cytochrome P450; Region: p450; cl12078 246197013868 Myxococcales GC_trans_RRR domain; Region: GC_trans_RRR; TIGR03382 246197013869 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 246197013870 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197013871 S-adenosylmethionine binding site [chemical binding]; other site 246197013872 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cl01109 246197013873 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 246197013874 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 246197013875 YcaO-like family; Region: YcaO; pfam02624 246197013876 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246197013877 Putative esterase; Region: Esterase; pfam00756 246197013878 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 246197013879 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 246197013880 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 246197013881 Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; Region: EGF_CA; cd00054 246197013882 Ca2+ binding site [ion binding]; other site 246197013883 Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the...; Region: EGF_CA; cd00054 246197013884 Ca2+ binding site [ion binding]; other site 246197013885 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 246197013886 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 246197013887 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 246197013888 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 246197013889 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 246197013890 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246197013891 FeS/SAM binding site; other site 246197013892 Predicted membrane protein [Function unknown]; Region: COG2261 246197013893 Chalcone-flavanone isomerase; Region: Chalcone; cl03589 246197013894 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 246197013895 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246197013896 catalytic residue [active] 246197013897 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 246197013898 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246197013899 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 246197013900 DNA binding residues [nucleotide binding] 246197013901 Caspase domain; Region: Peptidase_C14; pfam00656 246197013902 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 246197013903 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197013904 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 246197013905 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 246197013906 hypothetical protein; Provisional; Region: PRK05409 246197013907 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 246197013908 Zn binding site [ion binding]; other site 246197013909 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 246197013910 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246197013911 non-specific DNA binding site [nucleotide binding]; other site 246197013912 salt bridge; other site 246197013913 sequence-specific DNA binding site [nucleotide binding]; other site 246197013914 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 246197013915 Domain of unknown function (DUF955); Region: DUF955; pfam06114 246197013916 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 246197013917 Tetratricopeptide repeat; Region: TPR_12; pfam13424 246197013918 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197013919 binding surface 246197013920 TPR motif; other site 246197013921 Tetratricopeptide repeat; Region: TPR_12; pfam13424 246197013922 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 246197013923 multifunctional aminopeptidase A; Provisional; Region: PRK00913 246197013924 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 246197013925 interface (dimer of trimers) [polypeptide binding]; other site 246197013926 Substrate-binding/catalytic site; other site 246197013927 Zn-binding sites [ion binding]; other site 246197013928 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 246197013929 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 246197013930 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 246197013931 Thioredoxin; Region: Thioredoxin_4; pfam13462 246197013932 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 246197013933 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 246197013934 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 246197013935 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197013936 Walker A motif; other site 246197013937 ATP binding site [chemical binding]; other site 246197013938 Walker B motif; other site 246197013939 arginine finger; other site 246197013940 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 246197013941 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 246197013942 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 246197013943 RuvA N terminal domain; Region: RuvA_N; pfam01330 246197013944 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 246197013945 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 246197013946 active site 246197013947 putative DNA-binding cleft [nucleotide binding]; other site 246197013948 dimer interface [polypeptide binding]; other site 246197013949 hypothetical protein; Validated; Region: PRK00110 246197013950 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 246197013951 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197013952 active site 246197013953 phosphorylation site [posttranslational modification] 246197013954 intermolecular recognition site; other site 246197013955 dimerization interface [polypeptide binding]; other site 246197013956 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 246197013957 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 246197013958 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197013959 active site 246197013960 phosphorylation site [posttranslational modification] 246197013961 intermolecular recognition site; other site 246197013962 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197013963 Walker A motif; other site 246197013964 ATP binding site [chemical binding]; other site 246197013965 Walker B motif; other site 246197013966 arginine finger; other site 246197013967 CARDB; Region: CARDB; pfam07705 246197013968 CARDB; Region: CARDB; pfam07705 246197013969 CARDB; Region: CARDB; pfam07705 246197013970 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 246197013971 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 246197013972 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 246197013973 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 246197013974 putative active site [active] 246197013975 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 246197013976 hypothetical protein; Reviewed; Region: PRK09588 246197013977 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 246197013978 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 246197013979 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197013980 Walker A motif; other site 246197013981 ATP binding site [chemical binding]; other site 246197013982 Walker B motif; other site 246197013983 arginine finger; other site 246197013984 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 246197013985 active site 246197013986 Putative zinc-finger; Region: zf-HC2; pfam13490 246197013987 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197013988 binding surface 246197013989 TPR motif; other site 246197013990 Tetratricopeptide repeat; Region: TPR_16; pfam13432 246197013991 CHAT domain; Region: CHAT; cl17868 246197013992 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 246197013993 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246197013994 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246197013995 DNA binding residues [nucleotide binding] 246197013996 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197013997 dimer interface [polypeptide binding]; other site 246197013998 phosphorylation site [posttranslational modification] 246197013999 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197014000 ATP binding site [chemical binding]; other site 246197014001 Mg2+ binding site [ion binding]; other site 246197014002 G-X-G motif; other site 246197014003 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246197014004 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246197014005 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246197014006 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 246197014007 HTH domain; Region: HTH_11; pfam08279 246197014008 WYL domain; Region: WYL; pfam13280 246197014009 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 246197014010 DTW domain; Region: DTW; cl01221 246197014011 VanW like protein; Region: VanW; pfam04294 246197014012 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 246197014013 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 246197014014 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 246197014015 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 246197014016 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cd02106 246197014017 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 246197014018 cysteine desulfurase; Provisional; Region: PRK14012 246197014019 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 246197014020 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246197014021 catalytic residue [active] 246197014022 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 246197014023 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 246197014024 trimerization site [polypeptide binding]; other site 246197014025 active site 246197014026 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 246197014027 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 246197014028 co-chaperone HscB; Provisional; Region: hscB; PRK01773 246197014029 HSP70 interaction site [polypeptide binding]; other site 246197014030 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 246197014031 chaperone protein HscA; Provisional; Region: hscA; PRK05183 246197014032 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 246197014033 nucleotide binding site [chemical binding]; other site 246197014034 putative NEF/HSP70 interaction site [polypeptide binding]; other site 246197014035 SBD interface [polypeptide binding]; other site 246197014036 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 246197014037 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246197014038 catalytic loop [active] 246197014039 iron binding site [ion binding]; other site 246197014040 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 246197014041 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 246197014042 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 246197014043 active site 246197014044 Family description; Region: VCBS; pfam13517 246197014045 Family description; Region: VCBS; pfam13517 246197014046 Family description; Region: VCBS; pfam13517 246197014047 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 246197014048 active site 246197014049 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 246197014050 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246197014051 catalytic residue [active] 246197014052 Uncharacterized protein conserved in bacteria (DUF2247); Region: DUF2247; pfam10004 246197014053 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 246197014054 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 246197014055 diphosphomevalonate decarboxylase; Region: PLN02407 246197014056 diphosphomevalonate decarboxylase; Region: PLN02407 246197014057 mevalonate kinase; Region: mevalon_kin; TIGR00549 246197014058 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 246197014059 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 246197014060 homodimer interface [polypeptide binding]; other site 246197014061 catalytic residues [active] 246197014062 NAD binding site [chemical binding]; other site 246197014063 substrate binding pocket [chemical binding]; other site 246197014064 flexible flap; other site 246197014065 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 246197014066 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 246197014067 homotetramer interface [polypeptide binding]; other site 246197014068 FMN binding site [chemical binding]; other site 246197014069 homodimer contacts [polypeptide binding]; other site 246197014070 putative active site [active] 246197014071 putative substrate binding site [chemical binding]; other site 246197014072 DsrE/DsrF/DrsH-like family; Region: DrsE_2; cl17453 246197014073 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 246197014074 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 246197014075 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 246197014076 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 246197014077 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 246197014078 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 246197014079 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 246197014080 Imelysin; Region: Peptidase_M75; pfam09375 246197014081 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 246197014082 Peptidase family M48; Region: Peptidase_M48; cl12018 246197014083 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 246197014084 MarR family; Region: MarR; pfam01047 246197014085 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 246197014086 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 246197014087 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 246197014088 HlyD family secretion protein; Region: HlyD_3; pfam13437 246197014089 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 246197014090 glycoprotein BALF4; Provisional; Region: PHA03231 246197014091 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246197014092 dimerization interface [polypeptide binding]; other site 246197014093 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197014094 dimer interface [polypeptide binding]; other site 246197014095 phosphorylation site [posttranslational modification] 246197014096 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197014097 ATP binding site [chemical binding]; other site 246197014098 Mg2+ binding site [ion binding]; other site 246197014099 G-X-G motif; other site 246197014100 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 246197014101 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 246197014102 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 246197014103 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 246197014104 binding surface 246197014105 TPR motif; other site 246197014106 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197014107 TPR motif; other site 246197014108 binding surface 246197014109 Tetratricopeptide repeat; Region: TPR_16; pfam13432 246197014110 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 246197014111 Protein of unknown function (DUF779); Region: DUF779; pfam05610 246197014112 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 246197014113 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 246197014114 NAD(P) binding site [chemical binding]; other site 246197014115 catalytic residues [active] 246197014116 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 246197014117 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197014118 Walker A motif; other site 246197014119 ATP binding site [chemical binding]; other site 246197014120 Walker B motif; other site 246197014121 arginine finger; other site 246197014122 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 246197014123 DNA-binding interface [nucleotide binding]; DNA binding site 246197014124 Thrombospondin type 3 repeat; Region: TSP_3; pfam02412 246197014125 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 246197014126 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 246197014127 ligand binding site [chemical binding]; other site 246197014128 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 246197014129 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 246197014130 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 246197014131 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 246197014132 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 246197014133 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 246197014134 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 246197014135 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 246197014136 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 246197014137 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 246197014138 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 246197014139 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 246197014140 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 246197014141 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 246197014142 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 246197014143 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 246197014144 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 246197014145 Domain of unknown function (DUF4215); Region: DUF4215; pfam13948 246197014146 Myxococcus cysteine-rich repeat; Region: myxo_disulf_rpt; TIGR02232 246197014147 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 246197014148 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197014149 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197014150 active site 246197014151 ATP binding site [chemical binding]; other site 246197014152 substrate binding site [chemical binding]; other site 246197014153 activation loop (A-loop); other site 246197014154 TPR repeat; Region: TPR_11; pfam13414 246197014155 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197014156 TPR motif; other site 246197014157 binding surface 246197014158 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 246197014159 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197014160 Walker A motif; other site 246197014161 ATP binding site [chemical binding]; other site 246197014162 Walker B motif; other site 246197014163 arginine finger; other site 246197014164 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 246197014165 Short C-terminal domain; Region: SHOCT; pfam09851 246197014166 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 246197014167 Short C-terminal domain; Region: SHOCT; pfam09851 246197014168 Response regulator receiver domain; Region: Response_reg; pfam00072 246197014169 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197014170 active site 246197014171 phosphorylation site [posttranslational modification] 246197014172 intermolecular recognition site; other site 246197014173 dimerization interface [polypeptide binding]; other site 246197014174 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 246197014175 Response regulator receiver domain; Region: Response_reg; pfam00072 246197014176 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197014177 active site 246197014178 phosphorylation site [posttranslational modification] 246197014179 intermolecular recognition site; other site 246197014180 dimerization interface [polypeptide binding]; other site 246197014181 GAF domain; Region: GAF_3; pfam13492 246197014182 GAF domain; Region: GAF_2; pfam13185 246197014183 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 246197014184 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 246197014185 metal binding site [ion binding]; metal-binding site 246197014186 active site 246197014187 I-site; other site 246197014188 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 246197014189 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 246197014190 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 246197014191 Methyltransferase domain; Region: Methyltransf_11; pfam08241 246197014192 ribonucleoside--diphosphate reductase large subunit; Region: PLN02437 246197014193 ATP cone domain; Region: ATP-cone; pfam03477 246197014194 Class I ribonucleotide reductase; Region: RNR_I; cd01679 246197014195 active site 246197014196 dimer interface [polypeptide binding]; other site 246197014197 catalytic residues [active] 246197014198 effector binding site; other site 246197014199 R2 peptide binding site; other site 246197014200 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 246197014201 dimer interface [polypeptide binding]; other site 246197014202 putative radical transfer pathway; other site 246197014203 diiron center [ion binding]; other site 246197014204 tyrosyl radical; other site 246197014205 3-oxoacyl-(acyl carrier protein) synthase; Validated; Region: PRK06147 246197014206 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 246197014207 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 246197014208 conserved hypothetical protein; Region: TIGR02270 246197014209 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 246197014210 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 246197014211 amphipathic channel; other site 246197014212 Asn-Pro-Ala signature motifs; other site 246197014213 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 246197014214 active site 246197014215 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 246197014216 thymidine kinase; Provisional; Region: PRK04296 246197014217 regulatory protein SpoVG; Reviewed; Region: PRK13259 246197014218 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 246197014219 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 246197014220 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 246197014221 active site 246197014222 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 246197014223 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 246197014224 5S rRNA interface [nucleotide binding]; other site 246197014225 CTC domain interface [polypeptide binding]; other site 246197014226 L16 interface [polypeptide binding]; other site 246197014227 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 246197014228 putative active site [active] 246197014229 catalytic residue [active] 246197014230 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 246197014231 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 246197014232 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 246197014233 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 246197014234 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 246197014235 Acyltransferase family; Region: Acyl_transf_3; pfam01757 246197014236 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 246197014237 Histidine kinase; Region: His_kinase; pfam06580 246197014238 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197014239 ATP binding site [chemical binding]; other site 246197014240 Mg2+ binding site [ion binding]; other site 246197014241 G-X-G motif; other site 246197014242 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 246197014243 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197014244 active site 246197014245 phosphorylation site [posttranslational modification] 246197014246 intermolecular recognition site; other site 246197014247 dimerization interface [polypeptide binding]; other site 246197014248 LytTr DNA-binding domain; Region: LytTR; smart00850 246197014249 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 246197014250 replicative DNA helicase; Region: DnaB; TIGR00665 246197014251 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 246197014252 Walker A motif; other site 246197014253 ATP binding site [chemical binding]; other site 246197014254 Walker B motif; other site 246197014255 DNA binding loops [nucleotide binding] 246197014256 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 246197014257 ATP binding site [chemical binding]; other site 246197014258 substrate binding site [chemical binding]; other site 246197014259 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 246197014260 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 246197014261 catalytic triad [active] 246197014262 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 246197014263 thiamine phosphate binding site [chemical binding]; other site 246197014264 active site 246197014265 pyrophosphate binding site [ion binding]; other site 246197014266 Domain of unknown function (DUF1844); Region: DUF1844; pfam08899 246197014267 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 246197014268 Clp amino terminal domain; Region: Clp_N; pfam02861 246197014269 Clp amino terminal domain; Region: Clp_N; pfam02861 246197014270 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197014271 Walker A motif; other site 246197014272 ATP binding site [chemical binding]; other site 246197014273 Walker B motif; other site 246197014274 arginine finger; other site 246197014275 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197014276 Walker A motif; other site 246197014277 ATP binding site [chemical binding]; other site 246197014278 Walker B motif; other site 246197014279 arginine finger; other site 246197014280 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 246197014281 Methyltransferase domain; Region: Methyltransf_26; pfam13659 246197014282 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 246197014283 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 246197014284 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 246197014285 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 246197014286 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 246197014287 Protein of unknown function (DUF418); Region: DUF418; cl12135 246197014288 Protein of unknown function (DUF418); Region: DUF418; pfam04235 246197014289 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 246197014290 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 246197014291 metal binding site [ion binding]; metal-binding site 246197014292 putative dimer interface [polypeptide binding]; other site 246197014293 Predicted transcriptional regulators [Transcription]; Region: COG1733 246197014294 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 246197014295 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 246197014296 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 246197014297 NADP binding site [chemical binding]; other site 246197014298 RNA polymerase sigma factor, TIGR02999 family; Region: Sig-70_X6 246197014299 Arginine repressor [Transcription]; Region: ArgR; COG1438 246197014300 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 246197014301 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 246197014302 N-acetylornithine carbamoyltransferase; Reviewed; Region: PRK04523 246197014303 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 246197014304 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 246197014305 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 246197014306 nucleotide binding site [chemical binding]; other site 246197014307 substrate binding site [chemical binding]; other site 246197014308 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like5; cd05651 246197014309 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 246197014310 metal binding site [ion binding]; metal-binding site 246197014311 dimer interface [polypeptide binding]; other site 246197014312 Lyase; Region: Lyase_1; pfam00206 246197014313 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 246197014314 active sites [active] 246197014315 tetramer interface [polypeptide binding]; other site 246197014316 argininosuccinate synthase; Provisional; Region: PRK13820 246197014317 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 246197014318 Ligand Binding Site [chemical binding]; other site 246197014319 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 246197014320 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 246197014321 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 246197014322 Uncharacterized conserved protein [Function unknown]; Region: COG0398 246197014323 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 246197014324 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 246197014325 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 246197014326 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246197014327 Ligand Binding Site [chemical binding]; other site 246197014328 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246197014329 Ligand Binding Site [chemical binding]; other site 246197014330 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 246197014331 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 246197014332 dimerization interface 3.5A [polypeptide binding]; other site 246197014333 active site 246197014334 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246197014335 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197014336 active site 246197014337 ATP binding site [chemical binding]; other site 246197014338 substrate binding site [chemical binding]; other site 246197014339 activation loop (A-loop); other site 246197014340 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 246197014341 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 246197014342 putative RNA binding site [nucleotide binding]; other site 246197014343 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197014344 S-adenosylmethionine binding site [chemical binding]; other site 246197014345 putative selenium metabolism protein SsnA; Region: Se_ssnA; TIGR03314 246197014346 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246197014347 active site 246197014348 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246197014349 active site 246197014350 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 246197014351 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 246197014352 DNA binding residues [nucleotide binding] 246197014353 dimer interface [polypeptide binding]; other site 246197014354 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 246197014355 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246197014356 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 246197014357 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197014358 S-adenosylmethionine binding site [chemical binding]; other site 246197014359 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197014360 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197014361 dimer interface [polypeptide binding]; other site 246197014362 phosphorylation site [posttranslational modification] 246197014363 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 246197014364 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197014365 active site 246197014366 phosphorylation site [posttranslational modification] 246197014367 intermolecular recognition site; other site 246197014368 dimerization interface [polypeptide binding]; other site 246197014369 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197014370 Walker A motif; other site 246197014371 ATP binding site [chemical binding]; other site 246197014372 Walker B motif; other site 246197014373 arginine finger; other site 246197014374 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 246197014375 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 246197014376 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 246197014377 ligand binding site [chemical binding]; other site 246197014378 flexible hinge region; other site 246197014379 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 246197014380 putative switch regulator; other site 246197014381 non-specific DNA interactions [nucleotide binding]; other site 246197014382 DNA binding site [nucleotide binding] 246197014383 sequence specific DNA binding site [nucleotide binding]; other site 246197014384 putative cAMP binding site [chemical binding]; other site 246197014385 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 246197014386 phenylalanine 4-monooxygenase; Provisional; Region: PRK14056 246197014387 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 246197014388 cofactor binding site; other site 246197014389 metal binding site [ion binding]; metal-binding site 246197014390 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246197014391 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246197014392 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 246197014393 dimerization interface [polypeptide binding]; other site 246197014394 Sulfatase; Region: Sulfatase; cl17466 246197014395 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 246197014396 active site 246197014397 metal binding site [ion binding]; metal-binding site 246197014398 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 246197014399 HEAT repeats; Region: HEAT_2; pfam13646 246197014400 HEAT repeats; Region: HEAT_2; pfam13646 246197014401 HEAT repeats; Region: HEAT_2; pfam13646 246197014402 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 246197014403 metal ion-dependent adhesion site (MIDAS); other site 246197014404 MutS domain III; Region: MutS_III; pfam05192 246197014405 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246197014406 Walker A/P-loop; other site 246197014407 ATP binding site [chemical binding]; other site 246197014408 Q-loop/lid; other site 246197014409 ABC transporter signature motif; other site 246197014410 Walker B; other site 246197014411 D-loop; other site 246197014412 H-loop/switch region; other site 246197014413 acetyl-CoA acetyltransferase; Provisional; Region: PRK09052 246197014414 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 246197014415 dimer interface [polypeptide binding]; other site 246197014416 active site 246197014417 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 246197014418 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 246197014419 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 246197014420 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 246197014421 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246197014422 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 246197014423 substrate binding site [chemical binding]; other site 246197014424 oxyanion hole (OAH) forming residues; other site 246197014425 leukotriene A-4 hydrolase/aminopeptidase; Region: leuko_A4_hydro; TIGR02411 246197014426 Peptidase M1 family contains leukotriene A4 hydrolase; Region: M1_LTA4H; cd09599 246197014427 active site 246197014428 Zn binding site [ion binding]; other site 246197014429 Leukotriene A4 hydrolase, C-terminal; Region: Leuk-A4-hydro_C; pfam09127 246197014430 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 246197014431 DNA methylase; Region: N6_N4_Mtase; pfam01555 246197014432 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 246197014433 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 246197014434 active site 246197014435 metal binding site [ion binding]; metal-binding site 246197014436 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 246197014437 binding surface 246197014438 TPR motif; other site 246197014439 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 246197014440 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 246197014441 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197014442 active site 246197014443 phosphorylation site [posttranslational modification] 246197014444 intermolecular recognition site; other site 246197014445 dimerization interface [polypeptide binding]; other site 246197014446 CheB methylesterase; Region: CheB_methylest; pfam01339 246197014447 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 246197014448 putative binding surface; other site 246197014449 active site 246197014450 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197014451 ATP binding site [chemical binding]; other site 246197014452 Mg2+ binding site [ion binding]; other site 246197014453 G-X-G motif; other site 246197014454 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 246197014455 Response regulator receiver domain; Region: Response_reg; pfam00072 246197014456 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197014457 active site 246197014458 phosphorylation site [posttranslational modification] 246197014459 intermolecular recognition site; other site 246197014460 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246197014461 dimerization interface [polypeptide binding]; other site 246197014462 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 246197014463 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 246197014464 dimer interface [polypeptide binding]; other site 246197014465 putative CheW interface [polypeptide binding]; other site 246197014466 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 246197014467 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 246197014468 dimer interface [polypeptide binding]; other site 246197014469 putative CheW interface [polypeptide binding]; other site 246197014470 CheW-like domain; Region: CheW; pfam01584 246197014471 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 246197014472 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 246197014473 ligand binding site [chemical binding]; other site 246197014474 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 246197014475 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197014476 active site 246197014477 phosphorylation site [posttranslational modification] 246197014478 intermolecular recognition site; other site 246197014479 dimerization interface [polypeptide binding]; other site 246197014480 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197014481 Walker A motif; other site 246197014482 ATP binding site [chemical binding]; other site 246197014483 Walker B motif; other site 246197014484 arginine finger; other site 246197014485 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 246197014486 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 246197014487 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 246197014488 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246197014489 catalytic residue [active] 246197014490 AzlC protein; Region: AzlC; pfam03591 246197014491 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 246197014492 MreB/Mbl protein; Region: MreB_Mbl; pfam06723 246197014493 nucleotide binding site [chemical binding]; other site 246197014494 putative NEF/HSP70 interaction site [polypeptide binding]; other site 246197014495 SBD interface [polypeptide binding]; other site 246197014496 Predicted membrane protein [Function unknown]; Region: COG2259 246197014497 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 246197014498 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951 246197014499 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 246197014500 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 246197014501 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 246197014502 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 246197014503 ligand binding site [chemical binding]; other site 246197014504 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 246197014505 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 246197014506 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 246197014507 M28 Zn-Peptidase Aeromonas (Vibrio) proteolytica aminopeptidase; Region: M28_AAP; cd03879 246197014508 Peptidase family M28; Region: Peptidase_M28; pfam04389 246197014509 active site 246197014510 metal binding site [ion binding]; metal-binding site 246197014511 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 246197014512 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 246197014513 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 246197014514 Walker A/P-loop; other site 246197014515 ATP binding site [chemical binding]; other site 246197014516 Q-loop/lid; other site 246197014517 ABC transporter signature motif; other site 246197014518 Walker B; other site 246197014519 D-loop; other site 246197014520 H-loop/switch region; other site 246197014521 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 246197014522 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 246197014523 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 246197014524 FtsX-like permease family; Region: FtsX; pfam02687 246197014525 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 246197014526 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 246197014527 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 246197014528 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246197014529 FeS/SAM binding site; other site 246197014530 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 246197014531 HEXXH motif domain; Region: mod_HExxH; TIGR04267 246197014532 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 246197014533 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 246197014534 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246197014535 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197014536 active site 246197014537 ATP binding site [chemical binding]; other site 246197014538 substrate binding site [chemical binding]; other site 246197014539 activation loop (A-loop); other site 246197014540 Predicted integral membrane protein [Function unknown]; Region: COG5616 246197014541 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197014542 TPR motif; other site 246197014543 binding surface 246197014544 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 246197014545 putative catalytic site [active] 246197014546 putative phosphate binding site [ion binding]; other site 246197014547 active site 246197014548 metal binding site A [ion binding]; metal-binding site 246197014549 DNA binding site [nucleotide binding] 246197014550 putative AP binding site [nucleotide binding]; other site 246197014551 putative metal binding site B [ion binding]; other site 246197014552 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197014553 TPR motif; other site 246197014554 binding surface 246197014555 TPR repeat; Region: TPR_11; pfam13414 246197014556 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197014557 binding surface 246197014558 TPR motif; other site 246197014559 Transglycosylase; Region: Transgly; pfam00912 246197014560 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 246197014561 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 246197014562 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246197014563 dimerization interface [polypeptide binding]; other site 246197014564 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197014565 dimer interface [polypeptide binding]; other site 246197014566 phosphorylation site [posttranslational modification] 246197014567 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197014568 ATP binding site [chemical binding]; other site 246197014569 Mg2+ binding site [ion binding]; other site 246197014570 G-X-G motif; other site 246197014571 O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315 246197014572 Leucine carboxyl methyltransferase; Region: LCM; pfam04072 246197014573 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 246197014574 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 246197014575 30S subunit binding site; other site 246197014576 Response regulator receiver domain; Region: Response_reg; pfam00072 246197014577 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197014578 active site 246197014579 phosphorylation site [posttranslational modification] 246197014580 intermolecular recognition site; other site 246197014581 dimerization interface [polypeptide binding]; other site 246197014582 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 246197014583 Protein of unknown function (DUF1460); Region: DUF1460; pfam07313 246197014584 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 246197014585 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 246197014586 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 246197014587 ligand binding site [chemical binding]; other site 246197014588 tRNA pseudouridine synthase D (TruD); Region: TruD; pfam01142 246197014589 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 246197014590 Permutation of conserved domain; other site 246197014591 active site 246197014592 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 246197014593 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 246197014594 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 246197014595 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 246197014596 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 246197014597 active site 246197014598 homodimer interface [polypeptide binding]; other site 246197014599 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246197014600 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 246197014601 phosphopeptide binding site; other site 246197014602 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 246197014603 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 246197014604 metal binding site [ion binding]; metal-binding site 246197014605 active site 246197014606 I-site; other site 246197014607 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 246197014608 Yqey-like protein; Region: YqeY; pfam09424 246197014609 DNA primase, catalytic core; Region: dnaG; TIGR01391 246197014610 CHC2 zinc finger; Region: zf-CHC2; pfam01807 246197014611 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 246197014612 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 246197014613 active site 246197014614 metal binding site [ion binding]; metal-binding site 246197014615 interdomain interaction site; other site 246197014616 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 246197014617 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 246197014618 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 246197014619 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 246197014620 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246197014621 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 246197014622 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246197014623 DNA binding residues [nucleotide binding] 246197014624 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 246197014625 DNA binding site [nucleotide binding] 246197014626 active site 246197014627 DDE superfamily endonuclease; Region: DDE_5; pfam13546 246197014628 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 246197014629 classical (c) SDRs; Region: SDR_c; cd05233 246197014630 NAD(P) binding site [chemical binding]; other site 246197014631 active site 246197014632 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 246197014633 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246197014634 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246197014635 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 246197014636 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 246197014637 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197014638 dimer interface [polypeptide binding]; other site 246197014639 phosphorylation site [posttranslational modification] 246197014640 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197014641 ATP binding site [chemical binding]; other site 246197014642 G-X-G motif; other site 246197014643 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 246197014644 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197014645 active site 246197014646 phosphorylation site [posttranslational modification] 246197014647 intermolecular recognition site; other site 246197014648 dimerization interface [polypeptide binding]; other site 246197014649 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 246197014650 DNA binding site [nucleotide binding] 246197014651 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246197014652 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_4; cd06231 246197014653 putative active site [active] 246197014654 Zn binding site [ion binding]; other site 246197014655 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 246197014656 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 246197014657 putative active site [active] 246197014658 putative NTP binding site [chemical binding]; other site 246197014659 putative nucleic acid binding site [nucleotide binding]; other site 246197014660 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 246197014661 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 246197014662 alpha-dioxygenase; Region: PLN02283 246197014663 Animal heme oxidases similar to plant pathogen-inducible oxygenases; Region: PIOX_like; cd09818 246197014664 putative heme binding site [chemical binding]; other site 246197014665 putative active site [active] 246197014666 putative substrate binding site [chemical binding]; other site 246197014667 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 246197014668 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 246197014669 Moco binding site; other site 246197014670 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 246197014671 metal coordination site [ion binding]; other site 246197014672 Protein of unknown function, DUF488; Region: DUF488; pfam04343 246197014673 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 246197014674 AlkA N-terminal domain; Region: AlkA_N; smart01009 246197014675 Cupin domain; Region: Cupin_2; cl17218 246197014676 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 246197014677 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 246197014678 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 246197014679 Uncharacterized conserved protein [Function unknown]; Region: COG2128 246197014680 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 246197014681 L-aspartate oxidase; Provisional; Region: PRK06175 246197014682 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 246197014683 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 246197014684 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 246197014685 putative Iron-sulfur protein interface [polypeptide binding]; other site 246197014686 proximal heme binding site [chemical binding]; other site 246197014687 distal heme binding site [chemical binding]; other site 246197014688 putative dimer interface [polypeptide binding]; other site 246197014689 GTPases [General function prediction only]; Region: HflX; COG2262 246197014690 HflX GTPase family; Region: HflX; cd01878 246197014691 G1 box; other site 246197014692 GTP/Mg2+ binding site [chemical binding]; other site 246197014693 Switch I region; other site 246197014694 G2 box; other site 246197014695 G3 box; other site 246197014696 Switch II region; other site 246197014697 G4 box; other site 246197014698 G5 box; other site 246197014699 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 246197014700 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 246197014701 ATP binding site [chemical binding]; other site 246197014702 Mg++ binding site [ion binding]; other site 246197014703 motif III; other site 246197014704 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246197014705 nucleotide binding region [chemical binding]; other site 246197014706 ATP-binding site [chemical binding]; other site 246197014707 CAAX protease self-immunity; Region: Abi; pfam02517 246197014708 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 246197014709 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 246197014710 active site 246197014711 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 246197014712 active site 246197014713 ATP binding site [chemical binding]; other site 246197014714 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 246197014715 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 246197014716 Predicted membrane protein [Function unknown]; Region: COG3059 246197014717 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 246197014718 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246197014719 DNA binding residues [nucleotide binding] 246197014720 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 246197014721 putative substrate binding site [chemical binding]; other site 246197014722 active site 246197014723 Protein of unknown function (DUF1684); Region: DUF1684; cl01327 246197014724 Predicted esterase [General function prediction only]; Region: COG0400 246197014725 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 246197014726 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 246197014727 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 246197014728 C-terminal domain interface [polypeptide binding]; other site 246197014729 GSH binding site (G-site) [chemical binding]; other site 246197014730 dimer interface [polypeptide binding]; other site 246197014731 Histone deacetylase class IIa; Region: HDAC_classII_APAH; cd10001 246197014732 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 246197014733 active site 246197014734 Zn binding site [ion binding]; other site 246197014735 YCII-related domain; Region: YCII; cl00999 246197014736 Protein of unknown function (DUF3175); Region: DUF3175; pfam11373 246197014737 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 246197014738 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 246197014739 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 246197014740 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 246197014741 Galactose oxidase, central domain; Region: Kelch_3; cl02701 246197014742 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 246197014743 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 246197014744 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 246197014745 H+ Antiporter protein; Region: 2A0121; TIGR00900 246197014746 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246197014747 putative substrate translocation pore; other site 246197014748 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 246197014749 dinuclear metal binding motif [ion binding]; other site 246197014750 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 246197014751 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 246197014752 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 246197014753 sugar binding site [chemical binding]; other site 246197014754 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246197014755 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246197014756 DNA binding residues [nucleotide binding] 246197014757 dimerization interface [polypeptide binding]; other site 246197014758 Helix-turn-helix domain; Region: HTH_18; pfam12833 246197014759 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 246197014760 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246197014761 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 246197014762 Walker A/P-loop; other site 246197014763 ATP binding site [chemical binding]; other site 246197014764 Q-loop/lid; other site 246197014765 ABC transporter signature motif; other site 246197014766 Walker B; other site 246197014767 D-loop; other site 246197014768 H-loop/switch region; other site 246197014769 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 246197014770 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 246197014771 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246197014772 Walker A/P-loop; other site 246197014773 ATP binding site [chemical binding]; other site 246197014774 Q-loop/lid; other site 246197014775 ABC transporter signature motif; other site 246197014776 Walker B; other site 246197014777 D-loop; other site 246197014778 H-loop/switch region; other site 246197014779 Domain of unknown function (DUF3943); Region: DUF3943; pfam13084 246197014780 hypothetical protein; Provisional; Region: PHA03169 246197014781 Gram-negative bacterial tonB protein; Region: TonB; cl10048 246197014782 PEGA domain; Region: PEGA; pfam08308 246197014783 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 246197014784 Transglycosylase; Region: Transgly; pfam00912 246197014785 Domain of unknown function (DUF4034); Region: DUF4034; pfam13226 246197014786 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197014787 binding surface 246197014788 TPR motif; other site 246197014789 TPR repeat; Region: TPR_11; pfam13414 246197014790 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 246197014791 binding surface 246197014792 TPR motif; other site 246197014793 Uncharacterized conserved protein [Function unknown]; Region: COG5276 246197014794 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 246197014795 Prolyl oligopeptidase, N-terminal beta-propeller domain; Region: Peptidase_S9_N; pfam02897 246197014796 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246197014797 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 246197014798 Uncharacterized conserved protein [Function unknown]; Region: COG3391 246197014799 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 246197014800 AAA ATPase domain; Region: AAA_16; pfam13191 246197014801 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246197014802 DNA binding residues [nucleotide binding] 246197014803 dimerization interface [polypeptide binding]; other site 246197014804 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 246197014805 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 246197014806 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 246197014807 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 246197014808 Cupin domain; Region: Cupin_2; pfam07883 246197014809 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 246197014810 DNA-binding site [nucleotide binding]; DNA binding site 246197014811 RNA-binding motif; other site 246197014812 Heavy-metal resistance; Region: Metal_resist; pfam13801 246197014813 dimer interface [polypeptide binding]; other site 246197014814 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 246197014815 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197014816 active site 246197014817 phosphorylation site [posttranslational modification] 246197014818 intermolecular recognition site; other site 246197014819 dimerization interface [polypeptide binding]; other site 246197014820 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 246197014821 DNA binding site [nucleotide binding] 246197014822 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197014823 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246197014824 dimerization interface [polypeptide binding]; other site 246197014825 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197014826 dimer interface [polypeptide binding]; other site 246197014827 phosphorylation site [posttranslational modification] 246197014828 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197014829 ATP binding site [chemical binding]; other site 246197014830 Mg2+ binding site [ion binding]; other site 246197014831 G-X-G motif; other site 246197014832 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197014833 ABC-2 type transporter; Region: ABC2_membrane; cl17235 246197014834 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 246197014835 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 246197014836 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246197014837 Walker A/P-loop; other site 246197014838 ATP binding site [chemical binding]; other site 246197014839 Q-loop/lid; other site 246197014840 ABC transporter signature motif; other site 246197014841 Walker B; other site 246197014842 D-loop; other site 246197014843 H-loop/switch region; other site 246197014844 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 246197014845 UbiA prenyltransferase family; Region: UbiA; pfam01040 246197014846 TPR repeat; Region: TPR_11; pfam13414 246197014847 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197014848 binding surface 246197014849 TPR motif; other site 246197014850 TPR repeat; Region: TPR_11; pfam13414 246197014851 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197014852 binding surface 246197014853 TPR motif; other site 246197014854 TPR repeat; Region: TPR_11; pfam13414 246197014855 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197014856 TPR motif; other site 246197014857 binding surface 246197014858 TPR repeat; Region: TPR_11; pfam13414 246197014859 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197014860 TPR motif; other site 246197014861 binding surface 246197014862 Tetratricopeptide repeat; Region: TPR_12; pfam13424 246197014863 TPR repeat; Region: TPR_11; pfam13414 246197014864 Domain of unknown function (DUF2760); Region: DUF2760; pfam10816 246197014865 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 246197014866 nucleotide binding site [chemical binding]; other site 246197014867 putative NEF/HSP70 interaction site [polypeptide binding]; other site 246197014868 SBD interface [polypeptide binding]; other site 246197014869 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 246197014870 nucleotide binding site [chemical binding]; other site 246197014871 putative NEF/HSP70 interaction site [polypeptide binding]; other site 246197014872 SBD interface [polypeptide binding]; other site 246197014873 DNA-K related protein; Region: DUF3731; pfam12531 246197014874 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 246197014875 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 246197014876 active site 246197014877 metal binding site [ion binding]; metal-binding site 246197014878 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 246197014879 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 246197014880 Phytase; Region: Phytase; cl17685 246197014881 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 246197014882 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 246197014883 NADP-binding site; other site 246197014884 homotetramer interface [polypeptide binding]; other site 246197014885 substrate binding site [chemical binding]; other site 246197014886 homodimer interface [polypeptide binding]; other site 246197014887 active site 246197014888 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 246197014889 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 246197014890 NADP-binding site; other site 246197014891 homotetramer interface [polypeptide binding]; other site 246197014892 substrate binding site [chemical binding]; other site 246197014893 homodimer interface [polypeptide binding]; other site 246197014894 active site 246197014895 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 246197014896 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246197014897 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 246197014898 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246197014899 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 246197014900 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246197014901 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 246197014902 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 246197014903 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 246197014904 Ligand binding site; other site 246197014905 Ligand binding site; other site 246197014906 Ligand binding site; other site 246197014907 Putative Catalytic site; other site 246197014908 DXD motif; other site 246197014909 putative bifunctional glutamate synthase subunit beta/2-polyprenylphenol hydroxylase; Validated; Region: PRK06567 246197014910 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192 246197014911 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 246197014912 FAD binding pocket [chemical binding]; other site 246197014913 FAD binding motif [chemical binding]; other site 246197014914 phosphate binding motif [ion binding]; other site 246197014915 beta-alpha-beta structure motif; other site 246197014916 NAD binding pocket [chemical binding]; other site 246197014917 Iron coordination center [ion binding]; other site 246197014918 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 246197014919 catalytic core [active] 246197014920 iron donor protein CyaY; Region: FeS_CyaY; TIGR03421 246197014921 putative iron binding site [ion binding]; other site 246197014922 Response regulator receiver domain; Region: Response_reg; pfam00072 246197014923 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197014924 active site 246197014925 intermolecular recognition site; other site 246197014926 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 246197014927 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 246197014928 metal binding site [ion binding]; metal-binding site 246197014929 active site 246197014930 I-site; other site 246197014931 ribosome recycling factor; Reviewed; Region: frr; PRK00083 246197014932 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 246197014933 hinge region; other site 246197014934 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 246197014935 putative nucleotide binding site [chemical binding]; other site 246197014936 uridine monophosphate binding site [chemical binding]; other site 246197014937 homohexameric interface [polypeptide binding]; other site 246197014938 elongation factor Ts; Reviewed; Region: tsf; PRK12332 246197014939 UBA/TS-N domain; Region: UBA; pfam00627 246197014940 Elongation factor TS; Region: EF_TS; pfam00889 246197014941 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 246197014942 rRNA interaction site [nucleotide binding]; other site 246197014943 S8 interaction site; other site 246197014944 putative laminin-1 binding site; other site 246197014945 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 246197014946 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 246197014947 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246197014948 nucleotide binding region [chemical binding]; other site 246197014949 SEC-C motif; Region: SEC-C; pfam02810 246197014950 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2933 246197014951 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197014952 S-adenosylmethionine binding site [chemical binding]; other site 246197014953 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 246197014954 metal binding site [ion binding]; metal-binding site 246197014955 active site 246197014956 I-site; other site 246197014957 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 246197014958 Peptidase family M23; Region: Peptidase_M23; pfam01551 246197014959 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 246197014960 active site 246197014961 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 246197014962 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246197014963 Walker A/P-loop; other site 246197014964 ATP binding site [chemical binding]; other site 246197014965 Q-loop/lid; other site 246197014966 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 246197014967 ABC transporter signature motif; other site 246197014968 Walker B; other site 246197014969 D-loop; other site 246197014970 H-loop/switch region; other site 246197014971 SWIM zinc finger; Region: SWIM; pfam04434 246197014972 SNF2 Helicase protein; Region: DUF3670; pfam12419 246197014973 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 246197014974 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246197014975 ATP binding site [chemical binding]; other site 246197014976 putative Mg++ binding site [ion binding]; other site 246197014977 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246197014978 nucleotide binding region [chemical binding]; other site 246197014979 ATP-binding site [chemical binding]; other site 246197014980 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 246197014981 active site 246197014982 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246197014983 transcriptional regulator BetI; Validated; Region: PRK00767 246197014984 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246197014985 muropeptide transporter; Validated; Region: ampG; cl17669 246197014986 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 246197014987 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 246197014988 active site 246197014989 (T/H)XGH motif; other site 246197014990 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 246197014991 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 246197014992 1,4-alpha-glucan branching enzyme [Carbohydrate transport and metabolism]; Region: GlgB; COG0296 246197014993 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 246197014994 catalytic site [active] 246197014995 active site 246197014996 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 246197014997 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 246197014998 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 246197014999 active site 246197015000 metal binding site [ion binding]; metal-binding site 246197015001 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 246197015002 Uncharacterized conserved protein [Function unknown]; Region: COG1434 246197015003 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 246197015004 putative active site [active] 246197015005 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 246197015006 ATP-NAD kinase; Region: NAD_kinase; pfam01513 246197015007 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197015008 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 246197015009 active site 246197015010 phosphorylation site [posttranslational modification] 246197015011 intermolecular recognition site; other site 246197015012 dimerization interface [polypeptide binding]; other site 246197015013 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197015014 Walker A motif; other site 246197015015 ATP binding site [chemical binding]; other site 246197015016 Walker B motif; other site 246197015017 arginine finger; other site 246197015018 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 246197015019 Response regulator receiver domain; Region: Response_reg; pfam00072 246197015020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197015021 active site 246197015022 phosphorylation site [posttranslational modification] 246197015023 intermolecular recognition site; other site 246197015024 dimerization interface [polypeptide binding]; other site 246197015025 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197015026 dimer interface [polypeptide binding]; other site 246197015027 phosphorylation site [posttranslational modification] 246197015028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197015029 ATP binding site [chemical binding]; other site 246197015030 G-X-G motif; other site 246197015031 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 246197015032 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 246197015033 metal binding site [ion binding]; metal-binding site 246197015034 active site 246197015035 I-site; other site 246197015036 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 246197015037 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 246197015038 Ligand binding site; other site 246197015039 Putative Catalytic site; other site 246197015040 DXD motif; other site 246197015041 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 246197015042 Methyltransferase domain; Region: Methyltransf_23; pfam13489 246197015043 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197015044 S-adenosylmethionine binding site [chemical binding]; other site 246197015045 Mannosyltransferase (PIG-V)); Region: Mannosyl_trans2; pfam04188 246197015046 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 246197015047 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246197015048 substrate binding site [chemical binding]; other site 246197015049 oxyanion hole (OAH) forming residues; other site 246197015050 trimer interface [polypeptide binding]; other site 246197015051 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 246197015052 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 246197015053 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 246197015054 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 246197015055 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 246197015056 dimer interface [polypeptide binding]; other site 246197015057 active site 246197015058 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 246197015059 substrate binding site [chemical binding]; other site 246197015060 active site 246197015061 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 246197015062 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 246197015063 active site 246197015064 catalytic site [active] 246197015065 Starch binding domain; Region: CBM_2; smart01065 246197015066 starch-binding site 1 [chemical binding]; other site 246197015067 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 246197015068 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 246197015069 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 246197015070 active site 246197015071 catalytic site [active] 246197015072 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 246197015073 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 246197015074 Walker A/P-loop; other site 246197015075 ATP binding site [chemical binding]; other site 246197015076 Q-loop/lid; other site 246197015077 ABC transporter signature motif; other site 246197015078 Walker B; other site 246197015079 D-loop; other site 246197015080 H-loop/switch region; other site 246197015081 TOBE domain; Region: TOBE_2; pfam08402 246197015082 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 246197015083 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 246197015084 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 246197015085 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246197015086 dimer interface [polypeptide binding]; other site 246197015087 conserved gate region; other site 246197015088 putative PBP binding loops; other site 246197015089 ABC-ATPase subunit interface; other site 246197015090 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 246197015091 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246197015092 dimer interface [polypeptide binding]; other site 246197015093 conserved gate region; other site 246197015094 putative PBP binding loops; other site 246197015095 ABC-ATPase subunit interface; other site 246197015096 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 246197015097 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 246197015098 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 246197015099 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 246197015100 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 246197015101 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 246197015102 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 246197015103 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246197015104 NAD(P) binding site [chemical binding]; other site 246197015105 active site 246197015106 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 246197015107 active site 246197015108 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 246197015109 cleavage site 246197015110 active site 246197015111 substrate binding sites [chemical binding]; other site 246197015112 pyrimidine utilization protein D; Region: RutD; TIGR03611 246197015113 TAP-like protein; Region: Abhydrolase_4; pfam08386 246197015114 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 246197015115 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 246197015116 Uncharacterized conserved protein [Function unknown]; Region: COG5649 246197015117 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 246197015118 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 246197015119 active site 246197015120 Bacterial Ig-like domain; Region: Big_5; pfam13205 246197015121 Bacterial Ig-like domain; Region: Big_5; pfam13205 246197015122 Bacterial Ig-like domain; Region: Big_5; pfam13205 246197015123 Bacterial Ig-like domain; Region: Big_5; pfam13205 246197015124 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 246197015125 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246197015126 YCII-related domain; Region: YCII; cl00999 246197015127 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 246197015128 Zn binding site [ion binding]; other site 246197015129 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 246197015130 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 246197015131 calcium binding site 2 [ion binding]; other site 246197015132 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 246197015133 active site 246197015134 catalytic triad [active] 246197015135 calcium binding site 1 [ion binding]; other site 246197015136 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 246197015137 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 246197015138 nudix motif; other site 246197015139 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 246197015140 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 246197015141 cytosine deaminase; Provisional; Region: PRK05985 246197015142 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 246197015143 active site 246197015144 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 246197015145 nucleoside/Zn binding site; other site 246197015146 dimer interface [polypeptide binding]; other site 246197015147 catalytic motif [active] 246197015148 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 246197015149 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 246197015150 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 246197015151 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 246197015152 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 246197015153 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 246197015154 active site 246197015155 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 246197015156 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 246197015157 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 246197015158 putative active site [active] 246197015159 putative metal binding site [ion binding]; other site 246197015160 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 246197015161 hypothetical protein; Reviewed; Region: PRK09588 246197015162 Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951 246197015163 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 246197015164 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 246197015165 active site residue [active] 246197015166 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 246197015167 active site residue [active] 246197015168 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 246197015169 Beta/gamma crystallins; Region: XTALbg; smart00247 246197015170 Beta/Gamma crystallin; Region: Crystall; pfam00030 246197015171 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 246197015172 cleavage site 246197015173 active site 246197015174 substrate binding sites [chemical binding]; other site 246197015175 HTH-like domain; Region: HTH_21; pfam13276 246197015176 Integrase core domain; Region: rve; pfam00665 246197015177 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 246197015178 thioester formation/cholesterol transfer; other site 246197015179 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 246197015180 Zn binding site [ion binding]; other site 246197015181 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 246197015182 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 246197015183 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 246197015184 active site 246197015185 Zn binding site [ion binding]; other site 246197015186 Pretoxin HINT domain; Region: PT-HINT; pfam07591 246197015187 Predicted coiled-coil domain-containing protein (DUF2360); Region: DUF2360; pfam10152 246197015188 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 246197015189 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 246197015190 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 246197015191 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 246197015192 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 246197015193 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 246197015194 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 246197015195 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 246197015196 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 246197015197 FAD binding pocket [chemical binding]; other site 246197015198 FAD binding motif [chemical binding]; other site 246197015199 phosphate binding motif [ion binding]; other site 246197015200 beta-alpha-beta structure motif; other site 246197015201 NAD binding pocket [chemical binding]; other site 246197015202 Myxococcales GC_trans_RRR domain; Region: GC_trans_RRR; TIGR03382 246197015203 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 246197015204 PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818 246197015205 PA/protease or protease-like domain interface [polypeptide binding]; other site 246197015206 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 246197015207 Zn binding site [ion binding]; other site 246197015208 Bacterial Ig-like domain; Region: Big_5; pfam13205 246197015209 OTU-like cysteine protease; Region: OTU; pfam02338 246197015210 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197015211 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 246197015212 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 246197015213 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 246197015214 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 246197015215 putative di-iron ligands [ion binding]; other site 246197015216 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 246197015217 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 246197015218 active site 246197015219 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246197015220 Coenzyme A binding pocket [chemical binding]; other site 246197015221 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 246197015222 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 246197015223 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 246197015224 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 246197015225 putative sugar binding sites [chemical binding]; other site 246197015226 Q-X-W motif; other site 246197015227 Shewanella-like phosphatases, metallophosphatase domain; Region: MPP_Shelphs; cd07425 246197015228 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 246197015229 active site 246197015230 metal binding site [ion binding]; metal-binding site 246197015231 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246197015232 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 246197015233 NAD(P) binding site [chemical binding]; other site 246197015234 active site 246197015235 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197015236 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197015237 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197015238 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197015239 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197015240 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 246197015241 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 246197015242 C-terminal domain interface [polypeptide binding]; other site 246197015243 GSH binding site (G-site) [chemical binding]; other site 246197015244 dimer interface [polypeptide binding]; other site 246197015245 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 246197015246 substrate binding pocket (H-site) [chemical binding]; other site 246197015247 N-terminal domain interface [polypeptide binding]; other site 246197015248 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 246197015249 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 246197015250 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 246197015251 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 246197015252 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 246197015253 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 246197015254 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 246197015255 maltose O-acetyltransferase; Provisional; Region: PRK10092 246197015256 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 246197015257 trimer interface [polypeptide binding]; other site 246197015258 active site 246197015259 substrate binding site [chemical binding]; other site 246197015260 CoA binding site [chemical binding]; other site 246197015261 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246197015262 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246197015263 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 246197015264 dimerization interface [polypeptide binding]; other site 246197015265 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 246197015266 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 246197015267 Walker A motif; other site 246197015268 ATP binding site [chemical binding]; other site 246197015269 Family description; Region: UvrD_C_2; pfam13538 246197015270 PAS fold; Region: PAS_4; pfam08448 246197015271 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246197015272 putative active site [active] 246197015273 heme pocket [chemical binding]; other site 246197015274 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 246197015275 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 246197015276 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197015277 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197015278 dimer interface [polypeptide binding]; other site 246197015279 phosphorylation site [posttranslational modification] 246197015280 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197015281 ATP binding site [chemical binding]; other site 246197015282 Mg2+ binding site [ion binding]; other site 246197015283 G-X-G motif; other site 246197015284 Pectinacetylesterase; Region: PAE; pfam03283 246197015285 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 246197015286 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 246197015287 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 246197015288 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 246197015289 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 246197015290 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 246197015291 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 246197015292 tetramer (dimer of dimers) interface [polypeptide binding]; other site 246197015293 active site 246197015294 dimer interface [polypeptide binding]; other site 246197015295 Beta-propeller repeat; Region: SBBP; pfam06739 246197015296 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246197015297 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246197015298 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 246197015299 dimerization interface [polypeptide binding]; other site 246197015300 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 246197015301 FOG: WD40 repeat [General function prediction only]; Region: COG2319 246197015302 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 246197015303 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 246197015304 FOG: WD40 repeat [General function prediction only]; Region: COG2319 246197015305 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 246197015306 structural tetrad; other site 246197015307 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 246197015308 nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247 246197015309 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 246197015310 ArsC family; Region: ArsC; pfam03960 246197015311 putative ArsC-like catalytic residues; other site 246197015312 putative TRX-like catalytic residues [active] 246197015313 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 246197015314 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197015315 TPR repeat; Region: TPR_11; pfam13414 246197015316 binding surface 246197015317 TPR motif; other site 246197015318 SGNH_peri2; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri2; cd01829 246197015319 active site 246197015320 catalytic triad [active] 246197015321 oxyanion hole [active] 246197015322 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246197015323 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 246197015324 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246197015325 Walker A/P-loop; other site 246197015326 ATP binding site [chemical binding]; other site 246197015327 Q-loop/lid; other site 246197015328 ABC transporter signature motif; other site 246197015329 Walker B; other site 246197015330 D-loop; other site 246197015331 H-loop/switch region; other site 246197015332 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 246197015333 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 246197015334 substrate binding pocket [chemical binding]; other site 246197015335 membrane-bound complex binding site; other site 246197015336 hinge residues; other site 246197015337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246197015338 dimer interface [polypeptide binding]; other site 246197015339 conserved gate region; other site 246197015340 ABC-ATPase subunit interface; other site 246197015341 Predicted membrane protein [Function unknown]; Region: COG2510 246197015342 Response regulator receiver domain; Region: Response_reg; pfam00072 246197015343 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197015344 active site 246197015345 phosphorylation site [posttranslational modification] 246197015346 intermolecular recognition site; other site 246197015347 dimerization interface [polypeptide binding]; other site 246197015348 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 246197015349 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246197015350 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 246197015351 DNA binding residues [nucleotide binding] 246197015352 CHAT domain; Region: CHAT; cl17868 246197015353 AAA domain; Region: AAA_11; pfam13086 246197015354 Part of AAA domain; Region: AAA_19; pfam13245 246197015355 AAA domain; Region: AAA_30; pfam13604 246197015356 AAA domain; Region: AAA_12; pfam13087 246197015357 AAA ATPase domain; Region: AAA_16; pfam13191 246197015358 Family description; Region: UvrD_C_2; pfam13538 246197015359 uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904 246197015360 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 246197015361 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 246197015362 Protein of unknown function, DUF399; Region: DUF399; pfam04187 246197015363 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 246197015364 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 246197015365 RNA binding surface [nucleotide binding]; other site 246197015366 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 246197015367 active site 246197015368 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 246197015369 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197015370 active site 246197015371 ATP binding site [chemical binding]; other site 246197015372 substrate binding site [chemical binding]; other site 246197015373 activation loop (A-loop); other site 246197015374 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 246197015375 Beta-lactamase; Region: Beta-lactamase; pfam00144 246197015376 DoxX-like family; Region: DoxX_2; pfam13564 246197015377 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 246197015378 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 246197015379 lipase chaperone; Provisional; Region: PRK01294 246197015380 Proteobacterial lipase chaperone protein; Region: Lipase_chap; pfam03280 246197015381 Uncharacterized conserved protein [Function unknown]; Region: COG3791 246197015382 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 246197015383 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 246197015384 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 246197015385 putative dimer interface [polypeptide binding]; other site 246197015386 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 246197015387 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 246197015388 catalytic core [active] 246197015389 Hemerythrin-like domain; Region: Hr-like; cd12108 246197015390 Fe binding site [ion binding]; other site 246197015391 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 246197015392 HemN C-terminal domain; Region: HemN_C; pfam06969 246197015393 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246197015394 AAA domain; Region: AAA_21; pfam13304 246197015395 Walker A/P-loop; other site 246197015396 ATP binding site [chemical binding]; other site 246197015397 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 246197015398 Walker B; other site 246197015399 D-loop; other site 246197015400 H-loop/switch region; other site 246197015401 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 246197015402 4Fe-4S binding domain; Region: Fer4_5; pfam12801 246197015403 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 246197015404 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 246197015405 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 246197015406 putative bifunctional cbb3-type cytochrome c oxidase subunit I/II; Provisional; Region: PRK14485 246197015407 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 246197015408 Low-spin heme binding site [chemical binding]; other site 246197015409 Putative water exit pathway; other site 246197015410 Binuclear center (active site) [active] 246197015411 Putative proton exit pathway; other site 246197015412 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 246197015413 Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156 246197015414 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 246197015415 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 246197015416 Soluble P-type ATPase [General function prediction only]; Region: COG4087 246197015417 Family description; Region: DsbD_2; pfam13386 246197015418 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246197015419 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246197015420 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 246197015421 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246197015422 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246197015423 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 246197015424 enoyl-CoA hydratase; Provisional; Region: PRK06563 246197015425 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246197015426 substrate binding site [chemical binding]; other site 246197015427 oxyanion hole (OAH) forming residues; other site 246197015428 trimer interface [polypeptide binding]; other site 246197015429 Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757 246197015430 SEC-C motif; Region: SEC-C; pfam02810 246197015431 putative oxidoreductase; Provisional; Region: PRK11579 246197015432 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 246197015433 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 246197015434 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 246197015435 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 246197015436 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 246197015437 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 246197015438 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 246197015439 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 246197015440 molybdopterin cofactor binding site; other site 246197015441 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 246197015442 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 246197015443 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 246197015444 heme-binding residues [chemical binding]; other site 246197015445 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 246197015446 Cytochrome c; Region: Cytochrom_C; pfam00034 246197015447 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 246197015448 Predicted periplasmic lipoprotein (DUF2279); Region: DUF2279; cl11574 246197015449 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 246197015450 Acyltransferase family; Region: Acyl_transf_3; pfam01757 246197015451 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 246197015452 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 246197015453 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 246197015454 putative RNA binding site [nucleotide binding]; other site 246197015455 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197015456 S-adenosylmethionine binding site [chemical binding]; other site 246197015457 Flagellin N-methylase; Region: FliB; pfam03692 246197015458 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 246197015459 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246197015460 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 246197015461 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 246197015462 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 246197015463 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 246197015464 catalytic triad [active] 246197015465 conserved cis-peptide bond; other site 246197015466 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 246197015467 active site 246197015468 TonB C terminal; Region: TonB_2; pfam13103 246197015469 inorganic pyrophosphatase; Provisional; Region: PRK00642 246197015470 dimer interface [polypeptide binding]; other site 246197015471 substrate binding site [chemical binding]; other site 246197015472 metal binding sites [ion binding]; metal-binding site 246197015473 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 246197015474 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 246197015475 putative acyl-acceptor binding pocket; other site 246197015476 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 246197015477 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 246197015478 motif 1; other site 246197015479 dimer interface [polypeptide binding]; other site 246197015480 active site 246197015481 motif 2; other site 246197015482 motif 3; other site 246197015483 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 246197015484 Zn binding site [ion binding]; other site 246197015485 Fn3 associated; Region: Fn3_assoc; pfam13287 246197015486 CotH protein; Region: CotH; pfam08757 246197015487 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 246197015488 Short C-terminal domain; Region: SHOCT; pfam09851 246197015489 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 246197015490 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 246197015491 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 246197015492 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 246197015493 Walker A/P-loop; other site 246197015494 ATP binding site [chemical binding]; other site 246197015495 Q-loop/lid; other site 246197015496 ABC transporter signature motif; other site 246197015497 Walker B; other site 246197015498 D-loop; other site 246197015499 H-loop/switch region; other site 246197015500 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 246197015501 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 246197015502 Rhomboid family; Region: Rhomboid; cl11446 246197015503 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246197015504 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 246197015505 phosphopeptide binding site; other site 246197015506 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246197015507 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 246197015508 phosphopeptide binding site; other site 246197015509 TPR repeat; Region: TPR_11; pfam13414 246197015510 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197015511 TPR motif; other site 246197015512 binding surface 246197015513 Response regulator receiver domain; Region: Response_reg; pfam00072 246197015514 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197015515 active site 246197015516 phosphorylation site [posttranslational modification] 246197015517 intermolecular recognition site; other site 246197015518 dimerization interface [polypeptide binding]; other site 246197015519 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246197015520 non-specific DNA binding site [nucleotide binding]; other site 246197015521 salt bridge; other site 246197015522 sequence-specific DNA binding site [nucleotide binding]; other site 246197015523 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 246197015524 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246197015525 substrate binding site [chemical binding]; other site 246197015526 oxyanion hole (OAH) forming residues; other site 246197015527 trimer interface [polypeptide binding]; other site 246197015528 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 246197015529 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 246197015530 carboxyltransferase (CT) interaction site; other site 246197015531 biotinylation site [posttranslational modification]; other site 246197015532 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 246197015533 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 246197015534 ATP-grasp domain; Region: ATP-grasp_4; cl17255 246197015535 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 246197015536 cell division protein FtsZ; Validated; Region: PRK09330 246197015537 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 246197015538 nucleotide binding site [chemical binding]; other site 246197015539 SulA interaction site; other site 246197015540 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 246197015541 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 246197015542 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 246197015543 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 246197015544 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 246197015545 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 246197015546 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 246197015547 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 246197015548 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 246197015549 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 246197015550 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 246197015551 ligand binding site [chemical binding]; other site 246197015552 cell division protein FtsA; Region: ftsA; TIGR01174 246197015553 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 246197015554 nucleotide binding site [chemical binding]; other site 246197015555 Cell division protein FtsA; Region: FtsA; pfam14450 246197015556 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 246197015557 Cell division protein FtsQ; Region: FtsQ; pfam03799 246197015558 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 246197015559 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 246197015560 ATP-grasp domain; Region: ATP-grasp_4; cl17255 246197015561 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: PRK14652 246197015562 FAD binding domain; Region: FAD_binding_4; pfam01565 246197015563 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 246197015564 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 246197015565 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 246197015566 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 246197015567 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 246197015568 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 246197015569 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 246197015570 active site 246197015571 homodimer interface [polypeptide binding]; other site 246197015572 cell division protein FtsW; Region: ftsW; TIGR02614 246197015573 UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771 246197015574 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 246197015575 NAD(P) binding site [chemical binding]; other site 246197015576 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 246197015577 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 246197015578 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 246197015579 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 246197015580 Mg++ binding site [ion binding]; other site 246197015581 putative catalytic motif [active] 246197015582 putative substrate binding site [chemical binding]; other site 246197015583 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 246197015584 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 246197015585 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 246197015586 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 246197015587 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 246197015588 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 246197015589 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 246197015590 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 246197015591 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 246197015592 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 246197015593 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 246197015594 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 246197015595 Cell division protein FtsL; Region: FtsL; pfam04999 246197015596 MraW methylase family; Region: Methyltransf_5; cl17771 246197015597 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 246197015598 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 246197015599 anti sigma factor interaction site; other site 246197015600 regulatory phosphorylation site [posttranslational modification]; other site 246197015601 cell division protein MraZ; Reviewed; Region: PRK00326 246197015602 MraZ protein; Region: MraZ; pfam02381 246197015603 MraZ protein; Region: MraZ; pfam02381 246197015604 PilZ domain; Region: PilZ; cl01260 246197015605 PilZ domain; Region: PilZ; pfam07238 246197015606 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246197015607 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246197015608 active site 246197015609 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246197015610 dimerization interface [polypeptide binding]; other site 246197015611 putative DNA binding site [nucleotide binding]; other site 246197015612 putative Zn2+ binding site [ion binding]; other site 246197015613 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 246197015614 putative hydrophobic ligand binding site [chemical binding]; other site 246197015615 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197015616 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197015617 active site 246197015618 ATP binding site [chemical binding]; other site 246197015619 substrate binding site [chemical binding]; other site 246197015620 activation loop (A-loop); other site 246197015621 PEGA domain; Region: PEGA; pfam08308 246197015622 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 246197015623 Peptidase family M54, also called archaemetzincins or archaelysins; Region: Peptidase_M54; cl17349 246197015624 active site 246197015625 Zn binding site [ion binding]; other site 246197015626 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 246197015627 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 246197015628 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 246197015629 putative active site [active] 246197015630 metal binding site [ion binding]; metal-binding site 246197015631 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 246197015632 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 246197015633 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 246197015634 catalytic triad [active] 246197015635 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 246197015636 Domain of unknown function DUF20; Region: UPF0118; pfam01594 246197015637 transcription termination factor Rho; Provisional; Region: rho; PRK09376 246197015638 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 246197015639 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 246197015640 RNA binding site [nucleotide binding]; other site 246197015641 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 246197015642 multimer interface [polypeptide binding]; other site 246197015643 Walker A motif; other site 246197015644 ATP binding site [chemical binding]; other site 246197015645 Walker B motif; other site 246197015646 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 246197015647 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 246197015648 nucleotide binding pocket [chemical binding]; other site 246197015649 K-X-D-G motif; other site 246197015650 catalytic site [active] 246197015651 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 246197015652 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 246197015653 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 246197015654 Dimer interface [polypeptide binding]; other site 246197015655 BRCT sequence motif; other site 246197015656 Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254 246197015657 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 246197015658 homodimer interface [polypeptide binding]; other site 246197015659 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 246197015660 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 246197015661 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 246197015662 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 246197015663 IHF dimer interface [polypeptide binding]; other site 246197015664 IHF - DNA interface [nucleotide binding]; other site 246197015665 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 246197015666 FHIPEP family; Region: FHIPEP; pfam00771 246197015667 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 246197015668 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 246197015669 Type III secretory pathway, component EscT [Intracellular trafficking and secretion]; Region: EscT; COG4791 246197015670 Bacterial export proteins, family 3; Region: Bac_export_3; pfam01313 246197015671 type III secretion system protein; Reviewed; Region: PRK09617 246197015672 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 246197015673 type III secretion system apparatus protein YscQ/HrcQ; Region: SpaO_YscQ; TIGR02551 246197015674 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 246197015675 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 246197015676 PilZ domain; Region: PilZ; pfam07238 246197015677 Response regulator receiver domain; Region: Response_reg; pfam00072 246197015678 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197015679 active site 246197015680 phosphorylation site [posttranslational modification] 246197015681 intermolecular recognition site; other site 246197015682 dimerization interface [polypeptide binding]; other site 246197015683 TPR repeat; Region: TPR_11; pfam13414 246197015684 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197015685 binding surface 246197015686 TPR motif; other site 246197015687 TPR repeat; Region: TPR_11; pfam13414 246197015688 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 246197015689 binding surface 246197015690 TPR motif; other site 246197015691 Oxygen tolerance; Region: BatD; pfam13584 246197015692 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197015693 binding surface 246197015694 Tetratricopeptide repeat; Region: TPR_16; pfam13432 246197015695 TPR motif; other site 246197015696 Tetratricopeptide repeat; Region: TPR_16; pfam13432 246197015697 von Willebrand factor type A domain; Region: VWA_2; pfam13519 246197015698 metal ion-dependent adhesion site (MIDAS); other site 246197015699 VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467 246197015700 metal ion-dependent adhesion site (MIDAS); other site 246197015701 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 246197015702 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 246197015703 metal ion-dependent adhesion site (MIDAS); other site 246197015704 MoxR-like ATPases [General function prediction only]; Region: COG0714 246197015705 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197015706 Walker A motif; other site 246197015707 ATP binding site [chemical binding]; other site 246197015708 Walker B motif; other site 246197015709 arginine finger; other site 246197015710 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246197015711 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 246197015712 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 246197015713 nucleophilic elbow; other site 246197015714 catalytic triad; other site 246197015715 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 246197015716 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 246197015717 catalytic residues [active] 246197015718 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 246197015719 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246197015720 phosphopeptide binding site; other site 246197015721 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 246197015722 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197015723 Walker A motif; other site 246197015724 ATP binding site [chemical binding]; other site 246197015725 Walker B motif; other site 246197015726 arginine finger; other site 246197015727 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 246197015728 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 246197015729 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 246197015730 Domain of unknown function (DUF4401); Region: DUF4401; pfam14351 246197015731 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 246197015732 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl17299 246197015733 heme binding pocket [chemical binding]; other site 246197015734 heme ligand [chemical binding]; other site 246197015735 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197015736 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 246197015737 Walker A motif; other site 246197015738 ATP binding site [chemical binding]; other site 246197015739 Walker B motif; other site 246197015740 arginine finger; other site 246197015741 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197015742 S-adenosylmethionine binding site [chemical binding]; other site 246197015743 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 246197015744 ZIP Zinc transporter; Region: Zip; pfam02535 246197015745 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 246197015746 uncharacterized proteobacterial lipoprotein; Region: lp_; TIGR02722 246197015747 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 246197015748 Mechanosensitive ion channel; Region: MS_channel; pfam00924 246197015749 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 246197015750 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197015751 active site 246197015752 phosphorylation site [posttranslational modification] 246197015753 intermolecular recognition site; other site 246197015754 dimerization interface [polypeptide binding]; other site 246197015755 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 246197015756 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 246197015757 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 246197015758 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 246197015759 N-acetyl-D-glucosamine binding site [chemical binding]; other site 246197015760 catalytic residue [active] 246197015761 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 246197015762 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 246197015763 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 246197015764 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 246197015765 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 246197015766 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 246197015767 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 246197015768 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 246197015769 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 246197015770 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 246197015771 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 246197015772 active site 246197015773 substrate binding site [chemical binding]; other site 246197015774 Mg2+ binding site [ion binding]; other site 246197015775 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl15777 246197015776 putative active site pocket [active] 246197015777 dimerization interface [polypeptide binding]; other site 246197015778 putative catalytic residue [active] 246197015779 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 246197015780 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197015781 Walker A motif; other site 246197015782 ATP binding site [chemical binding]; other site 246197015783 Walker B motif; other site 246197015784 arginine finger; other site 246197015785 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246197015786 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197015787 active site 246197015788 ATP binding site [chemical binding]; other site 246197015789 substrate binding site [chemical binding]; other site 246197015790 activation loop (A-loop); other site 246197015791 PEGA domain; Region: PEGA; pfam08308 246197015792 FtsX-like permease family; Region: FtsX; pfam02687 246197015793 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 246197015794 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 246197015795 Walker A/P-loop; other site 246197015796 ATP binding site [chemical binding]; other site 246197015797 Q-loop/lid; other site 246197015798 ABC transporter signature motif; other site 246197015799 Walker B; other site 246197015800 D-loop; other site 246197015801 H-loop/switch region; other site 246197015802 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 246197015803 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 246197015804 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 246197015805 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197015806 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197015807 dimer interface [polypeptide binding]; other site 246197015808 phosphorylation site [posttranslational modification] 246197015809 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197015810 ATP binding site [chemical binding]; other site 246197015811 Mg2+ binding site [ion binding]; other site 246197015812 G-X-G motif; other site 246197015813 N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228 246197015814 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 246197015815 active site 246197015816 putative substrate binding pocket [chemical binding]; other site 246197015817 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 246197015818 active site 246197015819 catalytic motif [active] 246197015820 Zn binding site [ion binding]; other site 246197015821 Myxococcus xanthus paralogous domain TIGR02266; Region: gmx_TIGR02266 246197015822 SET domain; Region: SET; pfam00856 246197015823 B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; Region: BBOX; cl00034 246197015824 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 246197015825 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 246197015826 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 246197015827 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 246197015828 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 246197015829 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 246197015830 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 246197015831 ligand binding site [chemical binding]; other site 246197015832 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 246197015833 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 246197015834 Walker A/P-loop; other site 246197015835 ATP binding site [chemical binding]; other site 246197015836 Q-loop/lid; other site 246197015837 ABC transporter signature motif; other site 246197015838 Walker B; other site 246197015839 D-loop; other site 246197015840 H-loop/switch region; other site 246197015841 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 246197015842 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 246197015843 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 246197015844 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 246197015845 TM-ABC transporter signature motif; other site 246197015846 Response regulator receiver domain; Region: Response_reg; pfam00072 246197015847 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197015848 active site 246197015849 phosphorylation site [posttranslational modification] 246197015850 intermolecular recognition site; other site 246197015851 dimerization interface [polypeptide binding]; other site 246197015852 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197015853 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197015854 ATP binding site [chemical binding]; other site 246197015855 Mg2+ binding site [ion binding]; other site 246197015856 G-X-G motif; other site 246197015857 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 246197015858 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 246197015859 active site 246197015860 substrate binding site [chemical binding]; other site 246197015861 metal binding site [ion binding]; metal-binding site 246197015862 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; pfam01258 246197015863 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 246197015864 intersubunit interface [polypeptide binding]; other site 246197015865 active site 246197015866 catalytic residue [active] 246197015867 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 246197015868 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 246197015869 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 246197015870 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 246197015871 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 246197015872 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 246197015873 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 246197015874 TIGR02300 family protein; Region: FYDLN_acid 246197015875 Cna protein B-type domain; Region: Cna_B_2; pfam13715 246197015876 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 246197015877 Putative zinc ribbon domain; Region: DUF164; pfam02591 246197015878 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 246197015879 RNA/DNA hybrid binding site [nucleotide binding]; other site 246197015880 active site 246197015881 Uncharacterized conserved protein [Function unknown]; Region: COG4127 246197015882 Restriction endonuclease; Region: Mrr_cat; pfam04471 246197015883 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 246197015884 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 246197015885 putative active site [active] 246197015886 putative NTP binding site [chemical binding]; other site 246197015887 putative nucleic acid binding site [nucleotide binding]; other site 246197015888 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 246197015889 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246197015890 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 246197015891 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 246197015892 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 246197015893 P loop; other site 246197015894 GTP binding site [chemical binding]; other site 246197015895 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 246197015896 Zn binding site [ion binding]; other site 246197015897 PEGA domain; Region: PEGA; pfam08308 246197015898 Cellulose synthase catalytic subunit A2 (CESA2) is a catalytic subunit or a catalytic subunit substitute of the cellulose synthase complex; Region: CESA_CaSu_A2; cd06437 246197015899 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 246197015900 DXD motif; other site 246197015901 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 246197015902 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 246197015903 ATP-grasp domain; Region: ATP-grasp_4; cl17255 246197015904 PEGA domain; Region: PEGA; pfam08308 246197015905 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 246197015906 C-terminal peptidase (prc); Region: prc; TIGR00225 246197015907 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 246197015908 protein binding site [polypeptide binding]; other site 246197015909 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 246197015910 Catalytic dyad [active] 246197015911 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 246197015912 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 246197015913 catalytic site [active] 246197015914 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 246197015915 Peptidase family M23; Region: Peptidase_M23; pfam01551 246197015916 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 246197015917 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 246197015918 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246197015919 Walker A/P-loop; other site 246197015920 ATP binding site [chemical binding]; other site 246197015921 Q-loop/lid; other site 246197015922 ABC transporter signature motif; other site 246197015923 Walker B; other site 246197015924 D-loop; other site 246197015925 H-loop/switch region; other site 246197015926 Kua-ubiquitin conjugating enzyme hybrid localisation domain; Region: Kua-UEV1_localn; pfam10520 246197015927 glutamate racemase; Provisional; Region: PRK00865 246197015928 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 246197015929 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 246197015930 TolR protein; Region: tolR; TIGR02801 246197015931 TolA protein; Region: tolA_full; TIGR02794 246197015932 TonB C terminal; Region: TonB_2; pfam13103 246197015933 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 246197015934 TolB amino-terminal domain; Region: TolB_N; pfam04052 246197015935 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 246197015936 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 246197015937 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 246197015938 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 246197015939 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 246197015940 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 246197015941 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 246197015942 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246197015943 catalytic residue [active] 246197015944 exopolyphosphatase; Region: exo_poly_only; TIGR03706 246197015945 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 246197015946 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246197015947 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246197015948 putative substrate translocation pore; other site 246197015949 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 246197015950 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Region: LPLAT_AAK14816-like; cd07992 246197015951 putative acyl-acceptor binding pocket; other site 246197015952 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 246197015953 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 246197015954 Surface antigen; Region: Bac_surface_Ag; pfam01103 246197015955 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 246197015956 Family of unknown function (DUF490); Region: DUF490; pfam04357 246197015957 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 246197015958 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197015959 Walker A motif; other site 246197015960 ATP binding site [chemical binding]; other site 246197015961 Walker B motif; other site 246197015962 arginine finger; other site 246197015963 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197015964 binding surface 246197015965 TPR motif; other site 246197015966 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197015967 TPR motif; other site 246197015968 binding surface 246197015969 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 246197015970 TPR motif; other site 246197015971 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 246197015972 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 246197015973 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 246197015974 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 246197015975 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 246197015976 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 246197015977 carboxyltransferase (CT) interaction site; other site 246197015978 biotinylation site [posttranslational modification]; other site 246197015979 elongation factor P; Validated; Region: PRK00529 246197015980 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 246197015981 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 246197015982 RNA binding site [nucleotide binding]; other site 246197015983 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 246197015984 RNA binding site [nucleotide binding]; other site 246197015985 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 246197015986 AMIN domain; Region: AMIN; pfam11741 246197015987 AMIN domain; Region: AMIN; pfam11741 246197015988 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 246197015989 Secretin and TonB N terminus short domain; Region: STN; smart00965 246197015990 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 246197015991 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 246197015992 Pilus assembly protein, PilP; Region: PilP; pfam04351 246197015993 Pilus assembly protein, PilO; Region: PilO; pfam04350 246197015994 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 246197015995 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 246197015996 Cell division protein FtsA; Region: FtsA; cl17206 246197015997 Competence protein A; Region: Competence_A; pfam11104 246197015998 Cell division protein FtsA; Region: FtsA; pfam14450 246197015999 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 246197016000 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197016001 active site 246197016002 phosphorylation site [posttranslational modification] 246197016003 intermolecular recognition site; other site 246197016004 dimerization interface [polypeptide binding]; other site 246197016005 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197016006 Walker A motif; other site 246197016007 ATP binding site [chemical binding]; other site 246197016008 Walker B motif; other site 246197016009 arginine finger; other site 246197016010 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 246197016011 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197016012 dimer interface [polypeptide binding]; other site 246197016013 phosphorylation site [posttranslational modification] 246197016014 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197016015 ATP binding site [chemical binding]; other site 246197016016 Mg2+ binding site [ion binding]; other site 246197016017 G-X-G motif; other site 246197016018 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 246197016019 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 246197016020 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 246197016021 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 246197016022 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 246197016023 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 246197016024 Walker A/P-loop; other site 246197016025 ATP binding site [chemical binding]; other site 246197016026 Q-loop/lid; other site 246197016027 ABC transporter signature motif; other site 246197016028 Walker B; other site 246197016029 D-loop; other site 246197016030 H-loop/switch region; other site 246197016031 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 246197016032 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 246197016033 Type IV pilin PilA; Region: Pilin_PilA; pfam14245 246197016034 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 246197016035 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197016036 active site 246197016037 phosphorylation site [posttranslational modification] 246197016038 intermolecular recognition site; other site 246197016039 dimerization interface [polypeptide binding]; other site 246197016040 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197016041 Walker A motif; other site 246197016042 ATP binding site [chemical binding]; other site 246197016043 Walker B motif; other site 246197016044 arginine finger; other site 246197016045 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 246197016046 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 246197016047 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197016048 phosphorylation site [posttranslational modification] 246197016049 dimer interface [polypeptide binding]; other site 246197016050 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197016051 ATP binding site [chemical binding]; other site 246197016052 Mg2+ binding site [ion binding]; other site 246197016053 G-X-G motif; other site 246197016054 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 246197016055 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 246197016056 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 246197016057 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 246197016058 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 246197016059 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 246197016060 Walker A motif; other site 246197016061 ATP binding site [chemical binding]; other site 246197016062 Walker B motif; other site 246197016063 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 246197016064 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 246197016065 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 246197016066 Walker A motif; other site 246197016067 ATP binding site [chemical binding]; other site 246197016068 Walker B motif; other site 246197016069 riboflavin kinase/FMN adenylyltransferase; Region: ribF; TIGR00083 246197016070 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 246197016071 active site 246197016072 Riboflavin kinase; Region: Flavokinase; pfam01687 246197016073 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197016074 S-adenosylmethionine binding site [chemical binding]; other site 246197016075 Response regulator receiver domain; Region: Response_reg; pfam00072 246197016076 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197016077 active site 246197016078 phosphorylation site [posttranslational modification] 246197016079 intermolecular recognition site; other site 246197016080 dimerization interface [polypeptide binding]; other site 246197016081 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 246197016082 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 246197016083 metal binding site [ion binding]; metal-binding site 246197016084 active site 246197016085 I-site; other site 246197016086 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 246197016087 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 246197016088 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 246197016089 active site 246197016090 catalytic site [active] 246197016091 substrate binding site [chemical binding]; other site 246197016092 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 246197016093 HEAT repeats; Region: HEAT_2; pfam13646 246197016094 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 246197016095 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 246197016096 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 246197016097 Bacterial Ig-like domain; Region: Big_5; pfam13205 246197016098 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197016099 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 246197016100 RHS Repeat; Region: RHS_repeat; pfam05593 246197016101 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 246197016102 RHS Repeat; Region: RHS_repeat; pfam05593 246197016103 RHS Repeat; Region: RHS_repeat; pfam05593 246197016104 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 246197016105 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 246197016106 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 246197016107 IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; Region: IPT_PCSR; cd00603 246197016108 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 246197016109 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 246197016110 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 246197016111 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 246197016112 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 246197016113 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 246197016114 motif 1; other site 246197016115 active site 246197016116 motif 2; other site 246197016117 motif 3; other site 246197016118 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 246197016119 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 246197016120 Myxococcus xanthus paralogous domain TIGR02266; Region: gmx_TIGR02266 246197016121 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 246197016122 nucleotide binding site [chemical binding]; other site 246197016123 putative NEF/HSP70 interaction site [polypeptide binding]; other site 246197016124 SBD interface [polypeptide binding]; other site 246197016125 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 246197016126 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 246197016127 putative carboxyl-terminal-processing protease, deltaproteobacterial; Region: prc_long_Delta; TIGR03900 246197016128 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 246197016129 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 246197016130 protein binding site [polypeptide binding]; other site 246197016131 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 246197016132 Catalytic dyad [active] 246197016133 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 246197016134 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 246197016135 active site 246197016136 catalytic site [active] 246197016137 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 246197016138 zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719 246197016139 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 246197016140 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 246197016141 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 246197016142 P-loop; other site 246197016143 Magnesium ion binding site [ion binding]; other site 246197016144 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 246197016145 Magnesium ion binding site [ion binding]; other site 246197016146 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 246197016147 DTAP/Switch II; other site 246197016148 Switch I; other site 246197016149 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 246197016150 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 246197016151 P loop; other site 246197016152 Nucleotide binding site [chemical binding]; other site 246197016153 DTAP/Switch II; other site 246197016154 Switch I; other site 246197016155 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 246197016156 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 246197016157 Peptidase family M48; Region: Peptidase_M48; cl12018 246197016158 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197016159 TPR motif; other site 246197016160 binding surface 246197016161 TPR repeat; Region: TPR_11; pfam13414 246197016162 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 246197016163 PrkA AAA domain; Region: AAA_PrkA; smart00763 246197016164 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 246197016165 hypothetical protein; Provisional; Region: PRK05325 246197016166 SpoVR like protein; Region: SpoVR; pfam04293 246197016167 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 246197016168 putative peptidase; Provisional; Region: PRK11649 246197016169 Peptidase family M23; Region: Peptidase_M23; pfam01551 246197016170 Protein of unknown function (DUF2378); Region: DUF2378; pfam09536 246197016171 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 246197016172 homodimer interface [polypeptide binding]; other site 246197016173 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 246197016174 active site pocket [active] 246197016175 SnoaL-like domain; Region: SnoaL_2; pfam12680 246197016176 Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin; Region: M3A_TOP; cd06455 246197016177 active site 246197016178 Zn binding site [ion binding]; other site 246197016179 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 246197016180 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 246197016181 Interdomain contacts; other site 246197016182 Cytokine receptor motif; other site 246197016183 Lamin Tail Domain; Region: LTD; pfam00932 246197016184 short chain dehydrogenase; Provisional; Region: PRK07576 246197016185 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 246197016186 NAD(P) binding site [chemical binding]; other site 246197016187 substrate binding site [chemical binding]; other site 246197016188 homotetramer interface [polypeptide binding]; other site 246197016189 active site 246197016190 homodimer interface [polypeptide binding]; other site 246197016191 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 246197016192 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 246197016193 Peptidase family U32; Region: Peptidase_U32; pfam01136 246197016194 Collagenase; Region: DUF3656; pfam12392 246197016195 Quinolinate phosphoribosyl transferase, C-terminal domain; Region: QRPTase_C; pfam01729 246197016196 Peptidase family U32; Region: Peptidase_U32; cl03113 246197016197 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 246197016198 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 246197016199 prephenate dehydrogenase; Validated; Region: PRK08507 246197016200 Chorismate mutase type II; Region: CM_2; smart00830 246197016201 enoyl-CoA hydratase; Provisional; Region: PRK06142 246197016202 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246197016203 substrate binding site [chemical binding]; other site 246197016204 oxyanion hole (OAH) forming residues; other site 246197016205 trimer interface [polypeptide binding]; other site 246197016206 Myxococcus xanthus double-CXXCG motif paralogous family; Region: gmx_para_CXXCG; TIGR02264 246197016207 Myxococcus xanthus paralogous lipoprotein family TIGR02269; Region: TIGR02269 246197016208 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 246197016209 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 246197016210 active site 246197016211 PHP Thumb interface [polypeptide binding]; other site 246197016212 metal binding site [ion binding]; metal-binding site 246197016213 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 246197016214 generic binding surface II; other site 246197016215 generic binding surface I; other site 246197016216 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 246197016217 dimer interface [polypeptide binding]; other site 246197016218 Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_4; cd06231 246197016219 putative active site [active] 246197016220 Zn binding site [ion binding]; other site 246197016221 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 246197016222 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 246197016223 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 246197016224 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 246197016225 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246197016226 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 246197016227 NAD(P) binding site [chemical binding]; other site 246197016228 active site 246197016229 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 246197016230 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 246197016231 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 246197016232 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 246197016233 PAS domain; Region: PAS; smart00091 246197016234 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197016235 dimer interface [polypeptide binding]; other site 246197016236 phosphorylation site [posttranslational modification] 246197016237 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197016238 ATP binding site [chemical binding]; other site 246197016239 Mg2+ binding site [ion binding]; other site 246197016240 G-X-G motif; other site 246197016241 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 246197016242 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197016243 active site 246197016244 phosphorylation site [posttranslational modification] 246197016245 intermolecular recognition site; other site 246197016246 dimerization interface [polypeptide binding]; other site 246197016247 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197016248 Walker A motif; other site 246197016249 ATP binding site [chemical binding]; other site 246197016250 Walker B motif; other site 246197016251 arginine finger; other site 246197016252 acetyl-CoA synthetase; Provisional; Region: PRK00174 246197016253 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 246197016254 active site 246197016255 CoA binding site [chemical binding]; other site 246197016256 acyl-activating enzyme (AAE) consensus motif; other site 246197016257 AMP binding site [chemical binding]; other site 246197016258 acetate binding site [chemical binding]; other site 246197016259 Protein of unknown function, DUF485; Region: DUF485; pfam04341 246197016260 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 246197016261 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 246197016262 Na binding site [ion binding]; other site 246197016263 Ion transport protein; Region: Ion_trans; pfam00520 246197016264 Ion channel; Region: Ion_trans_2; pfam07885 246197016265 Double zinc ribbon; Region: DZR; pfam12773 246197016266 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 246197016267 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 246197016268 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 246197016269 Methyltransferase domain; Region: Methyltransf_26; pfam13659 246197016270 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 246197016271 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 246197016272 E-class dimer interface [polypeptide binding]; other site 246197016273 P-class dimer interface [polypeptide binding]; other site 246197016274 active site 246197016275 Cu2+ binding site [ion binding]; other site 246197016276 Zn2+ binding site [ion binding]; other site 246197016277 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 246197016278 metal ion-dependent adhesion site (MIDAS); other site 246197016279 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 246197016280 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 246197016281 Farnesoic acid 0-methyl transferase; Region: Methyltransf_FA; pfam12248 246197016282 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 246197016283 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 246197016284 active site 246197016285 alternative sigma factor RpoH; Region: rpoH_proteo; TIGR02392 246197016286 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246197016287 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 246197016288 DNA binding residues [nucleotide binding] 246197016289 helicase 45; Provisional; Region: PTZ00424 246197016290 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 246197016291 ATP binding site [chemical binding]; other site 246197016292 Mg++ binding site [ion binding]; other site 246197016293 motif III; other site 246197016294 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246197016295 nucleotide binding region [chemical binding]; other site 246197016296 ATP-binding site [chemical binding]; other site 246197016297 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246197016298 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 246197016299 sequence-specific DNA binding site [nucleotide binding]; other site 246197016300 salt bridge; other site 246197016301 glutamate dehydrogenase; Region: PLN02477 246197016302 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 246197016303 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 246197016304 NAD(P) binding site [chemical binding]; other site 246197016305 threonine dehydratase; Provisional; Region: PRK08198 246197016306 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 246197016307 tetramer interface [polypeptide binding]; other site 246197016308 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246197016309 catalytic residue [active] 246197016310 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 246197016311 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 246197016312 Uncharacterized conserved protein [Function unknown]; Region: COG2353 246197016313 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 246197016314 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 246197016315 putative active site [active] 246197016316 metal binding site [ion binding]; metal-binding site 246197016317 Activator of aromatic catabolism; Region: XylR_N; pfam06505 246197016318 The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989 246197016319 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 246197016320 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197016321 Walker A motif; other site 246197016322 ATP binding site [chemical binding]; other site 246197016323 Walker B motif; other site 246197016324 arginine finger; other site 246197016325 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 246197016326 Eukaryotic integral membrane protein (DUF1751); Region: DUF1751; pfam08551 246197016327 putative acyltransferase; Provisional; Region: PRK05790 246197016328 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 246197016329 dimer interface [polypeptide binding]; other site 246197016330 active site 246197016331 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 246197016332 DsbA family, 2-hydroxychromene-2-carboxylate (HCCA) isomerase subfamily; HCCA isomerase is a glutathione (GSH) dependent enzyme involved in the naphthalene catabolic pathway. It converts HCCA, a hemiketal formed spontaneously after ring cleavage of 1; Region: DsbA_HCCA_Iso; cd03022 246197016333 putative catalytic residue [active] 246197016334 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197016335 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197016336 active site 246197016337 ATP binding site [chemical binding]; other site 246197016338 substrate binding site [chemical binding]; other site 246197016339 activation loop (A-loop); other site 246197016340 AAA ATPase domain; Region: AAA_16; pfam13191 246197016341 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 246197016342 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 246197016343 active site 246197016344 substrate binding sites [chemical binding]; other site 246197016345 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 246197016346 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197016347 active site 246197016348 phosphorylation site [posttranslational modification] 246197016349 intermolecular recognition site; other site 246197016350 dimerization interface [polypeptide binding]; other site 246197016351 Uncharacterized conserved protein [Function unknown]; Region: COG3189 246197016352 Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123 246197016353 delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236 246197016354 Glutamate binding site [chemical binding]; other site 246197016355 NAD binding site [chemical binding]; other site 246197016356 catalytic residues [active] 246197016357 Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025 246197016358 active site 246197016359 catalytic residues [active] 246197016360 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 246197016361 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 246197016362 Integrase core domain; Region: rve; pfam00665 246197016363 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246197016364 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246197016365 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 246197016366 substrate binding pocket [chemical binding]; other site 246197016367 dimerization interface [polypeptide binding]; other site 246197016368 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246197016369 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246197016370 active site 246197016371 short chain dehydrogenase; Provisional; Region: PRK05650 246197016372 classical (c) SDRs; Region: SDR_c; cd05233 246197016373 NAD(P) binding site [chemical binding]; other site 246197016374 active site 246197016375 Phosphotransferase enzyme family; Region: APH; pfam01636 246197016376 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 246197016377 putative active site [active] 246197016378 putative substrate binding site [chemical binding]; other site 246197016379 ATP binding site [chemical binding]; other site 246197016380 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 246197016381 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 246197016382 catalytic core [active] 246197016383 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 246197016384 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246197016385 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 246197016386 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 246197016387 DNA binding site [nucleotide binding] 246197016388 active site 246197016389 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 246197016390 TrkA-N domain; Region: TrkA_N; pfam02254 246197016391 TrkA-C domain; Region: TrkA_C; pfam02080 246197016392 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 246197016393 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 246197016394 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 246197016395 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 246197016396 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246197016397 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246197016398 putative substrate translocation pore; other site 246197016399 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246197016400 dimerization interface [polypeptide binding]; other site 246197016401 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 246197016402 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 246197016403 dimer interface [polypeptide binding]; other site 246197016404 putative CheW interface [polypeptide binding]; other site 246197016405 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 246197016406 dimer interface [polypeptide binding]; other site 246197016407 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 246197016408 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 246197016409 active site 246197016410 Zn binding site [ion binding]; other site 246197016411 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 246197016412 classical (c) SDR, subgroup 6; Region: SDR_c6; cd05350 246197016413 putative NAD(P) binding site [chemical binding]; other site 246197016414 active site 246197016415 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 246197016416 active site 246197016417 dimer interface [polypeptide binding]; other site 246197016418 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 246197016419 Transglycosylase; Region: Transgly; pfam00912 246197016420 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 246197016421 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 246197016422 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 246197016423 RNA binding surface [nucleotide binding]; other site 246197016424 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 246197016425 active site 246197016426 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 246197016427 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 246197016428 MOSC domain; Region: MOSC; pfam03473 246197016429 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 246197016430 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 246197016431 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 246197016432 EamA-like transporter family; Region: EamA; pfam00892 246197016433 EamA-like transporter family; Region: EamA; pfam00892 246197016434 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246197016435 Coenzyme A binding pocket [chemical binding]; other site 246197016436 Cytochrome oxidase complex assembly protein 1; Region: Coa1; pfam08695 246197016437 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 246197016438 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 246197016439 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 246197016440 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 246197016441 Ligand binding site [chemical binding]; other site 246197016442 Electron transfer flavoprotein domain; Region: ETF; pfam01012 246197016443 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246197016444 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246197016445 active site 246197016446 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 246197016447 active site 246197016448 intersubunit interactions; other site 246197016449 catalytic residue [active] 246197016450 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 246197016451 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 246197016452 putative active site [active] 246197016453 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 246197016454 TPR repeat; Region: TPR_11; pfam13414 246197016455 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 246197016456 TPR motif; other site 246197016457 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 246197016458 binding surface 246197016459 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 246197016460 catalytic center binding site [active] 246197016461 ATP binding site [chemical binding]; other site 246197016462 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 246197016463 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 246197016464 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 246197016465 dihydrodipicolinate reductase; Provisional; Region: PRK00048 246197016466 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 246197016467 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 246197016468 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 246197016469 dihydrodipicolinate synthase; Region: dapA; TIGR00674 246197016470 dimer interface [polypeptide binding]; other site 246197016471 active site 246197016472 catalytic residue [active] 246197016473 diaminopimelate decarboxylase; Region: lysA; TIGR01048 246197016474 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 246197016475 active site 246197016476 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 246197016477 substrate binding site [chemical binding]; other site 246197016478 catalytic residues [active] 246197016479 dimer interface [polypeptide binding]; other site 246197016480 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 246197016481 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 246197016482 DNA binding site [nucleotide binding] 246197016483 catalytic residue [active] 246197016484 H2TH interface [polypeptide binding]; other site 246197016485 putative catalytic residues [active] 246197016486 turnover-facilitating residue; other site 246197016487 intercalation triad [nucleotide binding]; other site 246197016488 8OG recognition residue [nucleotide binding]; other site 246197016489 putative reading head residues; other site 246197016490 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 246197016491 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 246197016492 Peptidase family M48; Region: Peptidase_M48; pfam01435 246197016493 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 246197016494 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 246197016495 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 246197016496 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 246197016497 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3826 246197016498 EamA-like transporter family; Region: EamA; pfam00892 246197016499 EamA-like transporter family; Region: EamA; pfam00892 246197016500 epoxyqueuosine reductase; Region: TIGR00276 246197016501 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 246197016502 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 246197016503 thymidylate synthase; Reviewed; Region: thyA; PRK01827 246197016504 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 246197016505 dimerization interface [polypeptide binding]; other site 246197016506 active site 246197016507 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 246197016508 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 246197016509 folate binding site [chemical binding]; other site 246197016510 NADP+ binding site [chemical binding]; other site 246197016511 Cytochrome c; Region: Cytochrom_C; pfam00034 246197016512 Iron permease FTR1 family; Region: FTR1; cl00475 246197016513 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 246197016514 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 246197016515 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 246197016516 Zn2+ binding site [ion binding]; other site 246197016517 Mg2+ binding site [ion binding]; other site 246197016518 ATP-grasp domain; Region: ATP-grasp_4; cl17255 246197016519 putative acetyltransferase; Provisional; Region: PRK03624 246197016520 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246197016521 Coenzyme A binding pocket [chemical binding]; other site 246197016522 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 246197016523 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 246197016524 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 246197016525 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 246197016526 catalytic residues [active] 246197016527 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 246197016528 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 246197016529 amphipathic channel; other site 246197016530 Asn-Pro-Ala signature motifs; other site 246197016531 Protein of unknown function (DUF3419); Region: DUF3419; cl15422 246197016532 This CD includes the dihydrorhizobitoxine fatty acid desaturase (RtxC) characterized in Bradyrhizobium japonicum USDA110, and other related proteins. Dihydrorhizobitoxine desaturase is reported to be involved in the final step of rhizobitoxine...; Region: Rhizobitoxine-FADS-like; cd03510 246197016533 Fatty acid desaturase; Region: FA_desaturase; pfam00487 246197016534 putative di-iron ligands [ion binding]; other site 246197016535 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 246197016536 active site 246197016537 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 246197016538 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 246197016539 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 246197016540 tRNAHis guanylyltransferase; Region: Thg1; pfam04446 246197016541 Uncharacterized conserved protein [Function unknown]; Region: COG4021 246197016542 Thg1 C terminal domain; Region: Thg1C; pfam14413 246197016543 AAA domain; Region: AAA_33; pfam13671 246197016544 Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842 246197016545 active site 246197016546 catalytic triad [active] 246197016547 DNA gyrase, B subunit; Region: gyrB; TIGR01059 246197016548 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 246197016549 ATP binding site [chemical binding]; other site 246197016550 DNA helicase, putative; Region: TIGR00376 246197016551 AAA domain; Region: AAA_30; pfam13604 246197016552 AAA domain; Region: AAA_12; pfam13087 246197016553 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246197016554 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 246197016555 catalytic site [active] 246197016556 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197016557 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197016558 active site 246197016559 ATP binding site [chemical binding]; other site 246197016560 substrate binding site [chemical binding]; other site 246197016561 activation loop (A-loop); other site 246197016562 Uncharacterized conserved protein [Function unknown]; Region: COG3791 246197016563 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 246197016564 tellurite resistance protein terB; Region: terB; cd07176 246197016565 putative metal binding site [ion binding]; other site 246197016566 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 246197016567 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 246197016568 Ligand Binding Site [chemical binding]; other site 246197016569 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 246197016570 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 246197016571 catalytic site [active] 246197016572 putative active site [active] 246197016573 putative substrate binding site [chemical binding]; other site 246197016574 HRDC domain; Region: HRDC; pfam00570 246197016575 HRDC domain; Region: HRDC; pfam00570 246197016576 Peptidase family M1; Region: Peptidase_M1; pfam01433 246197016577 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 246197016578 Zn binding site [ion binding]; other site 246197016579 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 246197016580 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 246197016581 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197016582 S-adenosylmethionine binding site [chemical binding]; other site 246197016583 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 246197016584 dimerization interface [polypeptide binding]; other site 246197016585 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 246197016586 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 246197016587 active site 246197016588 Zn binding site [ion binding]; other site 246197016589 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197016590 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197016591 dimer interface [polypeptide binding]; other site 246197016592 phosphorylation site [posttranslational modification] 246197016593 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197016594 ATP binding site [chemical binding]; other site 246197016595 Mg2+ binding site [ion binding]; other site 246197016596 G-X-G motif; other site 246197016597 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 246197016598 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 246197016599 G1 box; other site 246197016600 putative GEF interaction site [polypeptide binding]; other site 246197016601 GTP/Mg2+ binding site [chemical binding]; other site 246197016602 Switch I region; other site 246197016603 G2 box; other site 246197016604 G3 box; other site 246197016605 Switch II region; other site 246197016606 G4 box; other site 246197016607 G5 box; other site 246197016608 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 246197016609 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 246197016610 homotrimer interaction site [polypeptide binding]; other site 246197016611 putative active site [active] 246197016612 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 246197016613 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197016614 active site 246197016615 phosphorylation site [posttranslational modification] 246197016616 intermolecular recognition site; other site 246197016617 dimerization interface [polypeptide binding]; other site 246197016618 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 246197016619 DNA binding site [nucleotide binding] 246197016620 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197016621 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197016622 dimer interface [polypeptide binding]; other site 246197016623 phosphorylation site [posttranslational modification] 246197016624 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197016625 ATP binding site [chemical binding]; other site 246197016626 Mg2+ binding site [ion binding]; other site 246197016627 G-X-G motif; other site 246197016628 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 246197016629 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 246197016630 Galactose oxidase, central domain; Region: Kelch_3; cl02701 246197016631 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 246197016632 Kelch domain; Region: Kelch; smart00612 246197016633 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 246197016634 Kelch domain; Region: Kelch; smart00612 246197016635 Galactose oxidase, central domain; Region: Kelch_3; cl02701 246197016636 Galactose oxidase, central domain; Region: Kelch_3; cl02701 246197016637 Galactose oxidase, central domain; Region: Kelch_3; cl02701 246197016638 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 246197016639 Galactose oxidase, central domain; Region: Kelch_3; cl02701 246197016640 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 246197016641 Galactose oxidase, central domain; Region: Kelch_3; cl02701 246197016642 Kelch motif; Region: Kelch_1; pfam01344 246197016643 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 246197016644 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 246197016645 Kelch domain; Region: Kelch; smart00612 246197016646 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 246197016647 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 246197016648 intersubunit interface [polypeptide binding]; other site 246197016649 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 246197016650 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 246197016651 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 246197016652 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246197016653 Walker A/P-loop; other site 246197016654 ATP binding site [chemical binding]; other site 246197016655 Q-loop/lid; other site 246197016656 ABC transporter signature motif; other site 246197016657 Walker B; other site 246197016658 D-loop; other site 246197016659 H-loop/switch region; other site 246197016660 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197016661 S-adenosylmethionine binding site [chemical binding]; other site 246197016662 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 246197016663 TAP-like protein; Region: Abhydrolase_4; pfam08386 246197016664 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 246197016665 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 246197016666 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 246197016667 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 246197016668 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 246197016669 putative active site [active] 246197016670 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197016671 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197016672 active site 246197016673 ATP binding site [chemical binding]; other site 246197016674 substrate binding site [chemical binding]; other site 246197016675 activation loop (A-loop); other site 246197016676 Tetratricopeptide repeat; Region: TPR_12; pfam13424 246197016677 Tetratricopeptide repeat; Region: TPR_12; pfam13424 246197016678 RNA polymerase sigma-70 factor, Myxococcales family 1; Region: Sig-70_gmx1; TIGR03001 246197016679 hypothetical protein; Provisional; Region: PRK07907 246197016680 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 246197016681 active site 246197016682 metal binding site [ion binding]; metal-binding site 246197016683 dimer interface [polypeptide binding]; other site 246197016684 Response regulator receiver domain; Region: Response_reg; pfam00072 246197016685 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197016686 active site 246197016687 phosphorylation site [posttranslational modification] 246197016688 intermolecular recognition site; other site 246197016689 dimerization interface [polypeptide binding]; other site 246197016690 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 246197016691 HSP70 interaction site [polypeptide binding]; other site 246197016692 Myxococcus xanthus paralogous domain TIGR02266; Region: gmx_TIGR02266 246197016693 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197016694 dimer interface [polypeptide binding]; other site 246197016695 phosphorylation site [posttranslational modification] 246197016696 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197016697 ATP binding site [chemical binding]; other site 246197016698 Mg2+ binding site [ion binding]; other site 246197016699 G-X-G motif; other site 246197016700 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 246197016701 FAD binding pocket [chemical binding]; other site 246197016702 FAD binding motif [chemical binding]; other site 246197016703 phosphate binding motif [ion binding]; other site 246197016704 beta-alpha-beta structure motif; other site 246197016705 NAD(p) ribose binding residues [chemical binding]; other site 246197016706 NAD binding pocket [chemical binding]; other site 246197016707 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 246197016708 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 246197016709 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 246197016710 putative acyl-acceptor binding pocket; other site 246197016711 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 246197016712 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 246197016713 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 246197016714 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 246197016715 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 246197016716 active site 246197016717 Methyltransferase domain; Region: Methyltransf_32; pfam13679 246197016718 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 246197016719 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 246197016720 Protein of unknown function (DUF2378); Region: DUF2378; pfam09536 246197016721 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 246197016722 Protein of unknown function, DUF482; Region: DUF482; pfam04339 246197016723 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 246197016724 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 246197016725 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197016726 Walker A motif; other site 246197016727 ATP binding site [chemical binding]; other site 246197016728 Walker B motif; other site 246197016729 arginine finger; other site 246197016730 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197016731 Walker A motif; other site 246197016732 ATP binding site [chemical binding]; other site 246197016733 Walker B motif; other site 246197016734 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 246197016735 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246197016736 dimerization interface [polypeptide binding]; other site 246197016737 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 246197016738 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 246197016739 dimer interface [polypeptide binding]; other site 246197016740 putative CheW interface [polypeptide binding]; other site 246197016741 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 246197016742 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197016743 active site 246197016744 phosphorylation site [posttranslational modification] 246197016745 intermolecular recognition site; other site 246197016746 dimerization interface [polypeptide binding]; other site 246197016747 CheB methylesterase; Region: CheB_methylest; pfam01339 246197016748 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 246197016749 putative binding surface; other site 246197016750 active site 246197016751 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197016752 ATP binding site [chemical binding]; other site 246197016753 Mg2+ binding site [ion binding]; other site 246197016754 G-X-G motif; other site 246197016755 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 246197016756 Response regulator receiver domain; Region: Response_reg; pfam00072 246197016757 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197016758 active site 246197016759 phosphorylation site [posttranslational modification] 246197016760 intermolecular recognition site; other site 246197016761 CheW-like domain; Region: CheW; pfam01584 246197016762 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197016763 S-adenosylmethionine binding site [chemical binding]; other site 246197016764 Response regulator receiver domain; Region: Response_reg; pfam00072 246197016765 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197016766 active site 246197016767 phosphorylation site [posttranslational modification] 246197016768 intermolecular recognition site; other site 246197016769 dimerization interface [polypeptide binding]; other site 246197016770 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 246197016771 Response regulator receiver domain; Region: Response_reg; pfam00072 246197016772 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197016773 active site 246197016774 phosphorylation site [posttranslational modification] 246197016775 intermolecular recognition site; other site 246197016776 dimerization interface [polypeptide binding]; other site 246197016777 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 246197016778 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 246197016779 NAD binding site [chemical binding]; other site 246197016780 homotetramer interface [polypeptide binding]; other site 246197016781 homodimer interface [polypeptide binding]; other site 246197016782 substrate binding site [chemical binding]; other site 246197016783 active site 246197016784 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 246197016785 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 246197016786 TPP-binding site [chemical binding]; other site 246197016787 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 246197016788 dimer interface [polypeptide binding]; other site 246197016789 PYR/PP interface [polypeptide binding]; other site 246197016790 TPP binding site [chemical binding]; other site 246197016791 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 246197016792 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 246197016793 E3 interaction surface; other site 246197016794 lipoyl attachment site [posttranslational modification]; other site 246197016795 e3 binding domain; Region: E3_binding; pfam02817 246197016796 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 246197016797 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 246197016798 DNA-binding site [nucleotide binding]; DNA binding site 246197016799 RNA-binding motif; other site 246197016800 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 246197016801 Dienelactone hydrolase family; Region: DLH; pfam01738 246197016802 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 246197016803 UPF0489 domain; Region: UPF0489; pfam12640 246197016804 Outer membrane protein/protective antigen OMA87 [Cell envelope biogenesis, outer membrane]; Region: COG4775 246197016805 Surface antigen; Region: Bac_surface_Ag; pfam01103 246197016806 Surface antigen; Region: Bac_surface_Ag; pfam01103 246197016807 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 246197016808 Endonuclease I; Region: Endonuclease_1; pfam04231 246197016809 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 246197016810 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 246197016811 cobalamin binding residues [chemical binding]; other site 246197016812 putative BtuC binding residues; other site 246197016813 dimer interface [polypeptide binding]; other site 246197016814 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197016815 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197016816 active site 246197016817 ATP binding site [chemical binding]; other site 246197016818 substrate binding site [chemical binding]; other site 246197016819 activation loop (A-loop); other site 246197016820 PEGA domain; Region: PEGA; pfam08308 246197016821 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 246197016822 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 246197016823 N-terminal plug; other site 246197016824 ligand-binding site [chemical binding]; other site 246197016825 Response regulator receiver domain; Region: Response_reg; pfam00072 246197016826 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197016827 active site 246197016828 phosphorylation site [posttranslational modification] 246197016829 intermolecular recognition site; other site 246197016830 dimerization interface [polypeptide binding]; other site 246197016831 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 246197016832 TMAO/DMSO reductase; Reviewed; Region: PRK05363 246197016833 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 246197016834 Moco binding site; other site 246197016835 metal coordination site [ion binding]; other site 246197016836 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 246197016837 Fatty acid desaturase; Region: FA_desaturase; pfam00487 246197016838 putative di-iron ligands [ion binding]; other site 246197016839 Nudix hydrolase homolog; Region: PLN02791 246197016840 heat shock protein 90; Provisional; Region: PRK05218 246197016841 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197016842 ATP binding site [chemical binding]; other site 246197016843 Mg2+ binding site [ion binding]; other site 246197016844 G-X-G motif; other site 246197016845 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 246197016846 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197016847 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197016848 dimer interface [polypeptide binding]; other site 246197016849 phosphorylation site [posttranslational modification] 246197016850 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197016851 ATP binding site [chemical binding]; other site 246197016852 Mg2+ binding site [ion binding]; other site 246197016853 G-X-G motif; other site 246197016854 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 246197016855 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 246197016856 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 246197016857 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 246197016858 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 246197016859 RNA polymerase factor sigma-70; Validated; Region: PRK08241 246197016860 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246197016861 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246197016862 DNA binding residues [nucleotide binding] 246197016863 SnoaL-like domain; Region: SnoaL_2; pfam12680 246197016864 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 246197016865 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 246197016866 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 246197016867 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 246197016868 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 246197016869 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 246197016870 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 246197016871 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 246197016872 active site 246197016873 ribulose/triose binding site [chemical binding]; other site 246197016874 phosphate binding site [ion binding]; other site 246197016875 substrate (anthranilate) binding pocket [chemical binding]; other site 246197016876 product (indole) binding pocket [chemical binding]; other site 246197016877 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 246197016878 active site 246197016879 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 246197016880 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 246197016881 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246197016882 catalytic residue [active] 246197016883 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 246197016884 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 246197016885 substrate binding site [chemical binding]; other site 246197016886 active site 246197016887 catalytic residues [active] 246197016888 heterodimer interface [polypeptide binding]; other site 246197016889 CARDB; Region: CARDB; pfam07705 246197016890 CARDB; Region: CARDB; pfam07705 246197016891 CARDB; Region: CARDB; pfam07705 246197016892 CARDB; Region: CARDB; pfam07705 246197016893 CARDB; Region: CARDB; pfam07705 246197016894 CARDB; Region: CARDB; pfam07705 246197016895 CARDB; Region: CARDB; pfam07705 246197016896 CARDB; Region: CARDB; pfam07705 246197016897 CARDB; Region: CARDB; pfam07705 246197016898 CARDB; Region: CARDB; pfam07705 246197016899 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 246197016900 catalytic core [active] 246197016901 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 246197016902 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 246197016903 glutamine binding [chemical binding]; other site 246197016904 catalytic triad [active] 246197016905 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 246197016906 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 246197016907 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 246197016908 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 246197016909 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 246197016910 ATP-dependent DNA ligase; Validated; Region: PRK09247 246197016911 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 246197016912 active site 246197016913 DNA binding site [nucleotide binding] 246197016914 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 246197016915 DNA binding site [nucleotide binding] 246197016916 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 246197016917 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246197016918 ATP binding site [chemical binding]; other site 246197016919 putative Mg++ binding site [ion binding]; other site 246197016920 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246197016921 nucleotide binding region [chemical binding]; other site 246197016922 ATP-binding site [chemical binding]; other site 246197016923 DEAD/H associated; Region: DEAD_assoc; pfam08494 246197016924 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 246197016925 putative active site [active] 246197016926 putative metal binding site [ion binding]; other site 246197016927 HNH endonuclease; Region: HNH; pfam01844 246197016928 active site 246197016929 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 246197016930 heme-binding residues [chemical binding]; other site 246197016931 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 246197016932 molybdopterin cofactor binding site; other site 246197016933 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 246197016934 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 246197016935 4Fe-4S binding domain; Region: Fer4_2; pfam12797 246197016936 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 246197016937 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 246197016938 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 246197016939 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 246197016940 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 246197016941 Cu(I) binding site [ion binding]; other site 246197016942 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 246197016943 Cytochrome c; Region: Cytochrom_C; pfam00034 246197016944 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 246197016945 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 246197016946 NorE_like subfamily of heme-copper oxidase subunit III. Heme-copper oxidases include cytochrome c and ubiquinol oxidases. Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862 246197016947 Subunit I/III interface [polypeptide binding]; other site 246197016948 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 246197016949 Protein of unknown function, DUF481; Region: DUF481; pfam04338 246197016950 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 246197016951 Flagellin N-methylase; Region: FliB; pfam03692 246197016952 putative hydrolase; Provisional; Region: PRK10985 246197016953 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197016954 active site 246197016955 phosphorylation site [posttranslational modification] 246197016956 intermolecular recognition site; other site 246197016957 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 246197016958 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246197016959 ATP binding site [chemical binding]; other site 246197016960 putative Mg++ binding site [ion binding]; other site 246197016961 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246197016962 nucleotide binding region [chemical binding]; other site 246197016963 ATP-binding site [chemical binding]; other site 246197016964 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG3372 246197016965 Protein of unknown function (DUF790); Region: DUF790; pfam05626 246197016966 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246197016967 sequence-specific DNA binding site [nucleotide binding]; other site 246197016968 salt bridge; other site 246197016969 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 246197016970 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 246197016971 active site 246197016972 metal binding site [ion binding]; metal-binding site 246197016973 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 246197016974 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 246197016975 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 246197016976 active site 246197016977 Zn binding site [ion binding]; other site 246197016978 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 246197016979 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 246197016980 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 246197016981 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 246197016982 NAD(P) binding site [chemical binding]; other site 246197016983 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 246197016984 XdhC Rossmann domain; Region: XdhC_C; pfam13478 246197016985 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 246197016986 Ligand binding site; other site 246197016987 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 246197016988 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246197016989 motif II; other site 246197016990 cyclase homology domain; Region: CHD; cd07302 246197016991 nucleotidyl binding site; other site 246197016992 metal binding site [ion binding]; metal-binding site 246197016993 dimer interface [polypeptide binding]; other site 246197016994 AAA ATPase domain; Region: AAA_16; pfam13191 246197016995 NACHT domain; Region: NACHT; pfam05729 246197016996 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197016997 TPR motif; other site 246197016998 Tetratricopeptide repeat; Region: TPR_12; pfam13424 246197016999 binding surface 246197017000 PAS domain S-box; Region: sensory_box; TIGR00229 246197017001 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246197017002 putative active site [active] 246197017003 heme pocket [chemical binding]; other site 246197017004 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246197017005 PAS fold; Region: PAS_3; pfam08447 246197017006 putative active site [active] 246197017007 heme pocket [chemical binding]; other site 246197017008 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 246197017009 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197017010 ATP binding site [chemical binding]; other site 246197017011 Mg2+ binding site [ion binding]; other site 246197017012 G-X-G motif; other site 246197017013 TIGR02452 family protein; Region: TIGR02452 246197017014 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 246197017015 glutathionine S-transferase; Provisional; Region: PRK10542 246197017016 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 246197017017 C-terminal domain interface [polypeptide binding]; other site 246197017018 GSH binding site (G-site) [chemical binding]; other site 246197017019 dimer interface [polypeptide binding]; other site 246197017020 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 246197017021 dimer interface [polypeptide binding]; other site 246197017022 N-terminal domain interface [polypeptide binding]; other site 246197017023 substrate binding pocket (H-site) [chemical binding]; other site 246197017024 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 246197017025 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 246197017026 active site 246197017027 hypothetical protein; Validated; Region: PRK07883 246197017028 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 246197017029 GIY-YIG motif/motif A; other site 246197017030 active site 246197017031 catalytic site [active] 246197017032 putative DNA binding site [nucleotide binding]; other site 246197017033 metal binding site [ion binding]; metal-binding site 246197017034 DDE superfamily endonuclease; Region: DDE_5; pfam13546 246197017035 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246197017036 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246197017037 Pirin; Region: Pirin; pfam02678 246197017038 Cadherin repeat-like domain; Region: CA_like; cl15786 246197017039 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 246197017040 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 246197017041 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 246197017042 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 246197017043 RibD C-terminal domain; Region: RibD_C; cl17279 246197017044 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 246197017045 Uncharacterized conserved protein [Function unknown]; Region: COG5361 246197017046 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 246197017047 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 246197017048 Lecithin retinol acyltransferase; Region: LRAT; pfam04970 246197017049 cytokinin dehydrogenase; Region: PLN02441 246197017050 FAD binding domain; Region: FAD_binding_4; pfam01565 246197017051 Cytokinin dehydrogenase 1, FAD and cytokinin binding; Region: Cytokin-bind; pfam09265 246197017052 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 246197017053 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 246197017054 PA_subtilisin_1: Protease-associated domain containing subtilisin-like proteases, subgroup 1. A subgroup of PA domain-containing subtilisin-like proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined; Region: PA_subtilisin_1; cd04818 246197017055 PA/protease or protease-like domain interface [polypeptide binding]; other site 246197017056 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 246197017057 Zn binding site [ion binding]; other site 246197017058 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 246197017059 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 246197017060 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 246197017061 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 246197017062 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 246197017063 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246197017064 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197017065 active site 246197017066 phosphorylation site [posttranslational modification] 246197017067 intermolecular recognition site; other site 246197017068 dimerization interface [polypeptide binding]; other site 246197017069 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246197017070 DNA binding residues [nucleotide binding] 246197017071 dimerization interface [polypeptide binding]; other site 246197017072 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 246197017073 Histidine kinase; Region: HisKA_3; pfam07730 246197017074 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 246197017075 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197017076 ATP binding site [chemical binding]; other site 246197017077 Mg2+ binding site [ion binding]; other site 246197017078 G-X-G motif; other site 246197017079 trigger factor; Provisional; Region: tig; PRK01490 246197017080 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 246197017081 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 246197017082 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 246197017083 PhnA protein; Region: PhnA; pfam03831 246197017084 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 246197017085 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 246197017086 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 246197017087 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 246197017088 catalytic residues [active] 246197017089 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 246197017090 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246197017091 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 246197017092 dimerization interface [polypeptide binding]; other site 246197017093 substrate binding pocket [chemical binding]; other site 246197017094 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 246197017095 classical (c) SDRs; Region: SDR_c; cd05233 246197017096 NAD(P) binding site [chemical binding]; other site 246197017097 active site 246197017098 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 246197017099 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 246197017100 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246197017101 DNA-binding site [nucleotide binding]; DNA binding site 246197017102 UTRA domain; Region: UTRA; pfam07702 246197017103 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 246197017104 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 246197017105 Methyltransferase domain; Region: Methyltransf_23; pfam13489 246197017106 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197017107 S-adenosylmethionine binding site [chemical binding]; other site 246197017108 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 246197017109 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 246197017110 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246197017111 catalytic residue [active] 246197017112 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246197017113 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246197017114 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 246197017115 dimerization interface [polypeptide binding]; other site 246197017116 substrate binding pocket [chemical binding]; other site 246197017117 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 246197017118 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 246197017119 Glucose dehydrogenase; Region: glucose_DH; cd08230 246197017120 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 246197017121 NADP binding site [chemical binding]; other site 246197017122 catalytic Zn binding site [ion binding]; other site 246197017123 structural Zn binding site [ion binding]; other site 246197017124 dimer interface [polypeptide binding]; other site 246197017125 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 246197017126 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 246197017127 active site 246197017128 catalytic tetrad [active] 246197017129 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 246197017130 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 246197017131 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 246197017132 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 246197017133 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 246197017134 HlyD family secretion protein; Region: HlyD_3; pfam13437 246197017135 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 246197017136 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 246197017137 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246197017138 Coenzyme A binding pocket [chemical binding]; other site 246197017139 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246197017140 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197017141 active site 246197017142 ATP binding site [chemical binding]; other site 246197017143 substrate binding site [chemical binding]; other site 246197017144 activation loop (A-loop); other site 246197017145 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 246197017146 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 246197017147 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 246197017148 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_1; cd07818 246197017149 putative hydrophobic ligand binding site [chemical binding]; other site 246197017150 hydroperoxidase II; Provisional; Region: katE; PRK11249 246197017151 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 246197017152 heme binding pocket [chemical binding]; other site 246197017153 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 246197017154 domain interactions; other site 246197017155 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u2; cd11494 246197017156 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 246197017157 Na binding site [ion binding]; other site 246197017158 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 246197017159 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 246197017160 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 246197017161 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 246197017162 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 246197017163 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 246197017164 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 246197017165 Protein of unknown function (DUF2911); Region: DUF2911; pfam11138 246197017166 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246197017167 Walker A/P-loop; other site 246197017168 ATP binding site [chemical binding]; other site 246197017169 AAA domain; Region: AAA_21; pfam13304 246197017170 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 246197017171 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 246197017172 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 246197017173 hydroxyglutarate oxidase; Provisional; Region: PRK11728 246197017174 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 246197017175 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 246197017176 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 246197017177 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 246197017178 inhibitor site; inhibition site 246197017179 active site 246197017180 dimer interface [polypeptide binding]; other site 246197017181 catalytic residue [active] 246197017182 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 246197017183 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 246197017184 dimer interface [polypeptide binding]; other site 246197017185 NADP binding site [chemical binding]; other site 246197017186 catalytic residues [active] 246197017187 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 246197017188 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 246197017189 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 246197017190 PAS fold; Region: PAS_4; pfam08448 246197017191 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246197017192 Helix-turn-helix domain; Region: HTH_18; pfam12833 246197017193 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246197017194 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 246197017195 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 246197017196 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246197017197 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 246197017198 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246197017199 DNA binding residues [nucleotide binding] 246197017200 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 246197017201 short chain dehydrogenase; Provisional; Region: PRK06179 246197017202 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 246197017203 NADP binding site [chemical binding]; other site 246197017204 active site 246197017205 steroid binding site; other site 246197017206 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 246197017207 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 246197017208 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 246197017209 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 246197017210 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246197017211 dimerization interface [polypeptide binding]; other site 246197017212 putative DNA binding site [nucleotide binding]; other site 246197017213 putative Zn2+ binding site [ion binding]; other site 246197017214 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 246197017215 active site 246197017216 substrate binding sites [chemical binding]; other site 246197017217 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 246197017218 tRNA synthetases class I (I, L, M and V); Region: tRNA-synt_1; pfam00133 246197017219 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 246197017220 active site 246197017221 HIGH motif; other site 246197017222 nucleotide binding site [chemical binding]; other site 246197017223 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 246197017224 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 246197017225 active site 246197017226 KMSKS motif; other site 246197017227 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 246197017228 tRNA binding surface [nucleotide binding]; other site 246197017229 anticodon binding site; other site 246197017230 Anticodon-binding domain of tRNA; Region: Anticodon_1; pfam08264 246197017231 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 246197017232 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246197017233 NAD(P) binding site [chemical binding]; other site 246197017234 active site 246197017235 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197017236 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 246197017237 phosphorylation site [posttranslational modification] 246197017238 dimer interface [polypeptide binding]; other site 246197017239 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197017240 ATP binding site [chemical binding]; other site 246197017241 Mg2+ binding site [ion binding]; other site 246197017242 G-X-G motif; other site 246197017243 Response regulator receiver domain; Region: Response_reg; pfam00072 246197017244 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197017245 active site 246197017246 phosphorylation site [posttranslational modification] 246197017247 intermolecular recognition site; other site 246197017248 dimerization interface [polypeptide binding]; other site 246197017249 conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806 246197017250 Prokaryotic RING finger family 4; Region: Prok-RING_4; pfam14447 246197017251 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246197017252 dimerization interface [polypeptide binding]; other site 246197017253 putative DNA binding site [nucleotide binding]; other site 246197017254 putative Zn2+ binding site [ion binding]; other site 246197017255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246197017256 Major Facilitator Superfamily; Region: MFS_1; pfam07690 246197017257 putative substrate translocation pore; other site 246197017258 DDE superfamily endonuclease; Region: DDE_3; pfam13358 246197017259 Right handed beta helix region; Region: Beta_helix; pfam13229 246197017260 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197017261 S-adenosylmethionine binding site [chemical binding]; other site 246197017262 Amyloid A4 N-terminal heparin-binding; Region: APP_N; pfam02177 246197017263 Amyloid A4 N-terminal heparin-binding; Region: APP_N; pfam02177 246197017264 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 246197017265 dimer interface [polypeptide binding]; other site 246197017266 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 246197017267 Galactose oxidase, central domain; Region: Kelch_3; pfam13415 246197017268 Kelch motif; Region: Kelch_6; pfam13964 246197017269 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 246197017270 Kelch domain; Region: Kelch; smart00612 246197017271 Kelch motif; Region: Kelch_1; pfam01344 246197017272 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 246197017273 HYR domain; Region: HYR; pfam02494 246197017274 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 246197017275 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 246197017276 ligand binding site [chemical binding]; other site 246197017277 Non-plant Terpene Cyclases, Class 1; Region: Terpene_cyclase_nonplant_C1; cd00687 246197017278 substrate binding pocket [chemical binding]; other site 246197017279 substrate-Mg2+ binding site; other site 246197017280 aspartate-rich region 1; other site 246197017281 active site lid residues [active] 246197017282 aspartate-rich region 2; other site 246197017283 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 246197017284 substrate binding pocket [chemical binding]; other site 246197017285 substrate-Mg2+ binding site; other site 246197017286 aspartate-rich region 1; other site 246197017287 aspartate-rich region 2; other site 246197017288 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 246197017289 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 246197017290 ligand binding site [chemical binding]; other site 246197017291 flexible hinge region; other site 246197017292 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 246197017293 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 246197017294 ligand binding site [chemical binding]; other site 246197017295 flexible hinge region; other site 246197017296 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 246197017297 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246197017298 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 246197017299 putative dimer interface [polypeptide binding]; other site 246197017300 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 246197017301 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 246197017302 protein-splicing catalytic site; other site 246197017303 thioester formation/cholesterol transfer; other site 246197017304 Pretoxin HINT domain; Region: PT-HINT; pfam07591 246197017305 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 246197017306 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246197017307 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246197017308 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 246197017309 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 246197017310 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 246197017311 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 246197017312 putative active site [active] 246197017313 putative NTP binding site [chemical binding]; other site 246197017314 putative nucleic acid binding site [nucleotide binding]; other site 246197017315 Uncharacterized conserved protein [Function unknown]; Region: COG3791 246197017316 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 246197017317 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246197017318 FeS/SAM binding site; other site 246197017319 Protein of unknown function (DUF962); Region: DUF962; pfam06127 246197017320 hypothetical protein; Provisional; Region: PRK06185 246197017321 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 246197017322 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 246197017323 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 246197017324 active site 246197017325 metal binding site [ion binding]; metal-binding site 246197017326 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 246197017327 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 246197017328 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 246197017329 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 246197017330 HEAT repeats; Region: HEAT_2; pfam13646 246197017331 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 246197017332 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 246197017333 putative active site [active] 246197017334 putative metal binding site [ion binding]; other site 246197017335 Ser-Thr-rich glycosyl-phosphatidyl-inositol-anchored membrane family; Region: GPI-anchored; pfam10342 246197017336 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246197017337 dimerization interface [polypeptide binding]; other site 246197017338 putative DNA binding site [nucleotide binding]; other site 246197017339 putative Zn2+ binding site [ion binding]; other site 246197017340 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 246197017341 putative hydrophobic ligand binding site [chemical binding]; other site 246197017342 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 246197017343 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 246197017344 substrate binding pocket [chemical binding]; other site 246197017345 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 246197017346 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 246197017347 catalytic motif [active] 246197017348 Catalytic residue [active] 246197017349 Aspartyl protease; Region: Asp_protease_2; pfam13650 246197017350 inhibitor binding site; inhibition site 246197017351 catalytic motif [active] 246197017352 Catalytic residue [active] 246197017353 Active site flap [active] 246197017354 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 246197017355 protein binding site [polypeptide binding]; other site 246197017356 Predicted transcriptional regulators [Transcription]; Region: COG1378 246197017357 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 246197017358 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 246197017359 C-terminal domain interface [polypeptide binding]; other site 246197017360 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 246197017361 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 246197017362 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 246197017363 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 246197017364 Integrase core domain; Region: rve; pfam00665 246197017365 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 246197017366 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 246197017367 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197017368 Walker A motif; other site 246197017369 ATP binding site [chemical binding]; other site 246197017370 Walker B motif; other site 246197017371 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 246197017372 A new structural DNA glycosylase; Region: AlkD_like; cd06561 246197017373 active site 246197017374 FOG: Transposase [DNA replication, recombination, and repair]; Region: COG5659 246197017375 Protein of unknown function, DUF600; Region: DUF600; cl04640 246197017376 Response regulator receiver domain; Region: Response_reg; pfam00072 246197017377 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197017378 active site 246197017379 phosphorylation site [posttranslational modification] 246197017380 intermolecular recognition site; other site 246197017381 dimerization interface [polypeptide binding]; other site 246197017382 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 246197017383 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 246197017384 substrate binding site [chemical binding]; other site 246197017385 hexamer interface [polypeptide binding]; other site 246197017386 metal binding site [ion binding]; metal-binding site 246197017387 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 246197017388 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 246197017389 Zn2+ binding site [ion binding]; other site 246197017390 Mg2+ binding site [ion binding]; other site 246197017391 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 246197017392 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 246197017393 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 246197017394 domain interfaces; other site 246197017395 active site 246197017396 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 246197017397 Domain of unknown function (DUF814); Region: DUF814; pfam05670 246197017398 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 246197017399 beta-galactosidase; Region: BGL; TIGR03356 246197017400 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 246197017401 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 246197017402 FMN binding site [chemical binding]; other site 246197017403 active site 246197017404 catalytic residues [active] 246197017405 substrate binding site [chemical binding]; other site 246197017406 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 246197017407 Peptidase family M50; Region: Peptidase_M50; pfam02163 246197017408 active site 246197017409 putative substrate binding region [chemical binding]; other site 246197017410 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 246197017411 Fatty acid desaturase; Region: FA_desaturase; pfam00487 246197017412 Di-iron ligands [ion binding]; other site 246197017413 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 246197017414 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 246197017415 Cl- selectivity filter; other site 246197017416 Cl- binding residues [ion binding]; other site 246197017417 pore gating glutamate residue; other site 246197017418 dimer interface [polypeptide binding]; other site 246197017419 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 246197017420 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 246197017421 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246197017422 Predicted acetyltransferase [General function prediction only]; Region: COG5628 246197017423 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 246197017424 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 246197017425 catalytic triad [active] 246197017426 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 246197017427 putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203 246197017428 active site 246197017429 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197017430 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197017431 active site 246197017432 ATP binding site [chemical binding]; other site 246197017433 substrate binding site [chemical binding]; other site 246197017434 activation loop (A-loop); other site 246197017435 TPR repeat; Region: TPR_11; pfam13414 246197017436 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197017437 binding surface 246197017438 TPR motif; other site 246197017439 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 246197017440 YdjC-like protein; Region: YdjC; pfam04794 246197017441 GAF domain; Region: GAF_3; pfam13492 246197017442 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197017443 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197017444 ATP binding site [chemical binding]; other site 246197017445 Mg2+ binding site [ion binding]; other site 246197017446 G-X-G motif; other site 246197017447 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197017448 7-cyano-7-deazaguanine reductase; Region: QueF-II; TIGR03139 246197017449 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246197017450 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197017451 active site 246197017452 ATP binding site [chemical binding]; other site 246197017453 substrate binding site [chemical binding]; other site 246197017454 activation loop (A-loop); other site 246197017455 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 246197017456 PLD-like domain; Region: PLDc_2; pfam13091 246197017457 putative active site [active] 246197017458 catalytic site [active] 246197017459 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 246197017460 PLD-like domain; Region: PLDc_2; pfam13091 246197017461 putative active site [active] 246197017462 catalytic site [active] 246197017463 Protein of unknown function (DUF3396); Region: DUF3396; pfam11876 246197017464 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 246197017465 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 246197017466 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 246197017467 Zn2+ binding site [ion binding]; other site 246197017468 Mg2+ binding site [ion binding]; other site 246197017469 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 246197017470 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 246197017471 NAD binding site [chemical binding]; other site 246197017472 catalytic Zn binding site [ion binding]; other site 246197017473 structural Zn binding site [ion binding]; other site 246197017474 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 246197017475 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 246197017476 classical (c) SDRs; Region: SDR_c; cd05233 246197017477 NAD(P) binding site [chemical binding]; other site 246197017478 active site 246197017479 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246197017480 non-specific DNA binding site [nucleotide binding]; other site 246197017481 salt bridge; other site 246197017482 sequence-specific DNA binding site [nucleotide binding]; other site 246197017483 Cupin domain; Region: Cupin_2; pfam07883 246197017484 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 246197017485 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 246197017486 Predicted lipoprotein of unknown function (DUF2380); Region: DUF2380; pfam09533 246197017487 Protein of unknown function (Gmx_para_CXXCG); Region: Gmx_para_CXXCG; pfam09535 246197017488 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 246197017489 PAS domain; Region: PAS_9; pfam13426 246197017490 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197017491 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197017492 ATP binding site [chemical binding]; other site 246197017493 Mg2+ binding site [ion binding]; other site 246197017494 G-X-G motif; other site 246197017495 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 246197017496 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197017497 active site 246197017498 phosphorylation site [posttranslational modification] 246197017499 intermolecular recognition site; other site 246197017500 Predicted integral membrane protein (DUF2270); Region: DUF2270; pfam10028 246197017501 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 246197017502 tartrate dehydrogenase; Region: TTC; TIGR02089 246197017503 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 246197017504 putative rRNA binding site [nucleotide binding]; other site 246197017505 Vitamin K epoxide reductase family in bacteria; Region: VKOR_3; cd12920 246197017506 putative active site [active] 246197017507 redox center [active] 246197017508 Thioredoxin; Region: Thioredoxin_4; cl17273 246197017509 Cupin domain; Region: Cupin_2; pfam07883 246197017510 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 246197017511 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 246197017512 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 246197017513 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197017514 S-adenosylmethionine binding site [chemical binding]; other site 246197017515 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 246197017516 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 246197017517 Chromate transporter; Region: Chromate_transp; pfam02417 246197017518 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 246197017519 maleylacetoacetate isomerase; Region: maiA; TIGR01262 246197017520 C-terminal domain interface [polypeptide binding]; other site 246197017521 GSH binding site (G-site) [chemical binding]; other site 246197017522 putative dimer interface [polypeptide binding]; other site 246197017523 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 246197017524 dimer interface [polypeptide binding]; other site 246197017525 N-terminal domain interface [polypeptide binding]; other site 246197017526 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 246197017527 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 246197017528 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 246197017529 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 246197017530 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 246197017531 Predicted periplasmic protein (DUF2271); Region: DUF2271; cl17856 246197017532 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 246197017533 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 246197017534 ligand binding site [chemical binding]; other site 246197017535 NAD binding site [chemical binding]; other site 246197017536 tetramer interface [polypeptide binding]; other site 246197017537 catalytic site [active] 246197017538 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 246197017539 L-serine binding site [chemical binding]; other site 246197017540 ACT domain interface; other site 246197017541 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 246197017542 FAD binding domain; Region: FAD_binding_4; pfam01565 246197017543 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197017544 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 246197017545 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 246197017546 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 246197017547 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 246197017548 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197017549 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 246197017550 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 246197017551 Peptidase family M28; Region: Peptidase_M28; pfam04389 246197017552 metal binding site [ion binding]; metal-binding site 246197017553 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246197017554 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246197017555 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 246197017556 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 246197017557 N-acetyl-D-glucosamine binding site [chemical binding]; other site 246197017558 catalytic residue [active] 246197017559 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 246197017560 active site 246197017561 trimer interface [polypeptide binding]; other site 246197017562 allosteric site; other site 246197017563 active site lid [active] 246197017564 hexamer (dimer of trimers) interface [polypeptide binding]; other site 246197017565 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 246197017566 Amidase; Region: Amidase; pfam01425 246197017567 6-phosphofructokinase; Provisional; Region: PRK03202 246197017568 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 246197017569 active site 246197017570 ADP/pyrophosphate binding site [chemical binding]; other site 246197017571 dimerization interface [polypeptide binding]; other site 246197017572 allosteric effector site; other site 246197017573 fructose-1,6-bisphosphate binding site; other site 246197017574 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 246197017575 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 246197017576 dimer interface [polypeptide binding]; other site 246197017577 acyl-activating enzyme (AAE) consensus motif; other site 246197017578 putative active site [active] 246197017579 AMP binding site [chemical binding]; other site 246197017580 putative CoA binding site [chemical binding]; other site 246197017581 Lactoylglutathione lyase and related lyases [Amino acid transport and metabolism]; Region: GloA; COG0346 246197017582 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 246197017583 haloalkane dehalogenase; Provisional; Region: PRK00870 246197017584 protoporphyrinogen oxidase; Region: proto_IX_ox; TIGR00562 246197017585 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246197017586 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 246197017587 phosphopeptide binding site; other site 246197017588 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 246197017589 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 246197017590 putative active site [active] 246197017591 putative metal binding site [ion binding]; other site 246197017592 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 246197017593 intersubunit interface [polypeptide binding]; other site 246197017594 active site 246197017595 Zn2+ binding site [ion binding]; other site 246197017596 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 246197017597 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 246197017598 5'-methylthioadenosine phosphorylase; Provisional; Region: PRK08931 246197017599 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 246197017600 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 246197017601 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 246197017602 active site 246197017603 zinc binding site [ion binding]; other site 246197017604 type 2 lantibiotic, mersacidin/lichenicidin family; Region: lanti_MRSA_kill; TIGR03898 246197017605 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 246197017606 Phosphopantetheine attachment site; Region: PP-binding; cl09936 246197017607 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 246197017608 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 246197017609 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 246197017610 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 246197017611 dimer interface [polypeptide binding]; other site 246197017612 active site 246197017613 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK06519 246197017614 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 246197017615 active site 246197017616 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 246197017617 active site 2 [active] 246197017618 active site 1 [active] 246197017619 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 246197017620 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246197017621 NAD(P) binding site [chemical binding]; other site 246197017622 active site 246197017623 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246197017624 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 246197017625 NAD(P) binding site [chemical binding]; other site 246197017626 active site 246197017627 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 246197017628 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 246197017629 dimer interface [polypeptide binding]; other site 246197017630 active site 246197017631 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 246197017632 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 246197017633 dimer interface [polypeptide binding]; other site 246197017634 active site 246197017635 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 246197017636 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 246197017637 Walker A/P-loop; other site 246197017638 ATP binding site [chemical binding]; other site 246197017639 Q-loop/lid; other site 246197017640 ABC transporter signature motif; other site 246197017641 Walker B; other site 246197017642 D-loop; other site 246197017643 H-loop/switch region; other site 246197017644 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 246197017645 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 246197017646 FtsX-like permease family; Region: FtsX; pfam02687 246197017647 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197017648 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 246197017649 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 246197017650 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 246197017651 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 246197017652 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 246197017653 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 246197017654 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 246197017655 IPT/TIG domain; Region: TIG; pfam01833 246197017656 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 246197017657 putative active site [active] 246197017658 catalytic site [active] 246197017659 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 246197017660 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 246197017661 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 246197017662 putative active site [active] 246197017663 catalytic site [active] 246197017664 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 246197017665 Beta-lactamase; Region: Beta-lactamase; pfam00144 246197017666 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197017667 binding surface 246197017668 TPR repeat; Region: TPR_11; pfam13414 246197017669 TPR motif; other site 246197017670 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 246197017671 Protein-arginine deiminase (PAD) middle domain; Region: PAD_M; pfam08527 246197017672 Protein-arginine deiminase (PAD); Region: PAD; pfam03068 246197017673 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 246197017674 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197017675 active site 246197017676 phosphorylation site [posttranslational modification] 246197017677 intermolecular recognition site; other site 246197017678 dimerization interface [polypeptide binding]; other site 246197017679 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 246197017680 DNA binding site [nucleotide binding] 246197017681 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197017682 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197017683 dimer interface [polypeptide binding]; other site 246197017684 phosphorylation site [posttranslational modification] 246197017685 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197017686 ATP binding site [chemical binding]; other site 246197017687 G-X-G motif; other site 246197017688 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197017689 von Willebrand factor; Region: vWF_A; pfam12450 246197017690 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 246197017691 D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813 246197017692 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 246197017693 Ligand Binding Site [chemical binding]; other site 246197017694 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197017695 TPR motif; other site 246197017696 binding surface 246197017697 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197017698 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197017699 active site 246197017700 ATP binding site [chemical binding]; other site 246197017701 substrate binding site [chemical binding]; other site 246197017702 activation loop (A-loop); other site 246197017703 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 246197017704 cyclase homology domain; Region: CHD; cd07302 246197017705 nucleotidyl binding site; other site 246197017706 metal binding site [ion binding]; metal-binding site 246197017707 dimer interface [polypeptide binding]; other site 246197017708 NlpC/P60 family; Region: NLPC_P60; cl17555 246197017709 Ribosome receptor lysine/proline rich region; Region: Rib_recp_KP_reg; pfam05104 246197017710 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 246197017711 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 246197017712 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 246197017713 minor groove reading motif; other site 246197017714 helix-hairpin-helix signature motif; other site 246197017715 substrate binding pocket [chemical binding]; other site 246197017716 active site 246197017717 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197017718 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 246197017719 Walker A motif; other site 246197017720 ATP binding site [chemical binding]; other site 246197017721 Walker B motif; other site 246197017722 arginine finger; other site 246197017723 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197017724 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197017725 active site 246197017726 ATP binding site [chemical binding]; other site 246197017727 substrate binding site [chemical binding]; other site 246197017728 activation loop (A-loop); other site 246197017729 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 246197017730 TPR motif; other site 246197017731 binding surface 246197017732 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 246197017733 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 246197017734 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 246197017735 putative active site [active] 246197017736 catalytic site [active] 246197017737 acyl-CoA oxidase; Region: PLN02312 246197017738 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246197017739 active site 246197017740 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 246197017741 Putative Zn-dependent protease [General function prediction only]; Region: COG4784 246197017742 Peptidase family M48; Region: Peptidase_M48; pfam01435 246197017743 Protein of unknown function (DUF3293); Region: DUF3293; pfam11697 246197017744 Clp protease; Region: CLP_protease; pfam00574 246197017745 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 246197017746 oligomer interface [polypeptide binding]; other site 246197017747 active site residues [active] 246197017748 fumarate hydratase; Reviewed; Region: fumC; PRK00485 246197017749 Class II fumarases; Region: Fumarase_classII; cd01362 246197017750 active site 246197017751 tetramer interface [polypeptide binding]; other site 246197017752 PspC domain; Region: PspC; pfam04024 246197017753 malate synthase A; Region: malate_syn_A; TIGR01344 246197017754 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 246197017755 active site 246197017756 isocitrate lyase; Provisional; Region: PRK15063 246197017757 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 246197017758 tetramer interface [polypeptide binding]; other site 246197017759 active site 246197017760 Mg2+/Mn2+ binding site [ion binding]; other site 246197017761 Protein of unknown function (Gmx_para_CXXCG); Region: Gmx_para_CXXCG; cl15282 246197017762 Protein of unknown function (Gmx_para_CXXCG); Region: Gmx_para_CXXCG; cl15282 246197017763 Predicted lipoprotein of unknown function (DUF2380); Region: DUF2380; pfam09533 246197017764 B12-binding domain/radical SAM domain protein, MJ_1487 family; Region: B12_SAM_MJ_1487; TIGR04013 246197017765 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 246197017766 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246197017767 FeS/SAM binding site; other site 246197017768 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 246197017769 Beta-lactamase; Region: Beta-lactamase; pfam00144 246197017770 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 246197017771 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 246197017772 Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958 246197017773 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 246197017774 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 246197017775 dimer interface [polypeptide binding]; other site 246197017776 putative CheW interface [polypeptide binding]; other site 246197017777 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 246197017778 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 246197017779 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 246197017780 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 246197017781 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14470 246197017782 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 246197017783 FeS/SAM binding site; other site 246197017784 Putative zinc-finger; Region: zf-HC2; pfam13490 246197017785 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 246197017786 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246197017787 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246197017788 DNA binding residues [nucleotide binding] 246197017789 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 246197017790 active site 246197017791 DNA binding site [nucleotide binding] 246197017792 4-alpha-glucanotransferase; Provisional; Region: PRK14508 246197017793 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 246197017794 Surface antigen; Region: Bac_surface_Ag; pfam01103 246197017795 Family of unknown function (DUF490); Region: DUF490; pfam04357 246197017796 Family of unknown function (DUF490); Region: DUF490; pfam04357 246197017797 LysR family transcriptional regulator; Provisional; Region: PRK14997 246197017798 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246197017799 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 246197017800 putative effector binding pocket; other site 246197017801 dimerization interface [polypeptide binding]; other site 246197017802 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 246197017803 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 246197017804 catalytic residues [active] 246197017805 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 246197017806 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 246197017807 metal ion-dependent adhesion site (MIDAS); other site 246197017808 Protein of unknown function DUF58; Region: DUF58; pfam01882 246197017809 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 246197017810 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 246197017811 Walker A/P-loop; other site 246197017812 ATP binding site [chemical binding]; other site 246197017813 Q-loop/lid; other site 246197017814 ABC transporter signature motif; other site 246197017815 Walker B; other site 246197017816 D-loop; other site 246197017817 H-loop/switch region; other site 246197017818 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 246197017819 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197017820 Walker A motif; other site 246197017821 ATP binding site [chemical binding]; other site 246197017822 Walker B motif; other site 246197017823 arginine finger; other site 246197017824 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 246197017825 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 246197017826 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 246197017827 active site 246197017828 catalytic tetrad [active] 246197017829 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 246197017830 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 246197017831 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 246197017832 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 246197017833 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 246197017834 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 246197017835 MarR family; Region: MarR; pfam01047 246197017836 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 246197017837 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 246197017838 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 246197017839 iron-sulfur cluster [ion binding]; other site 246197017840 [2Fe-2S] cluster binding site [ion binding]; other site 246197017841 Protein of unknown function, DUF547; Region: DUF547; pfam04784 246197017842 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 246197017843 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 246197017844 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 246197017845 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 246197017846 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246197017847 motif II; other site 246197017848 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 246197017849 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 246197017850 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 246197017851 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 246197017852 HEAT repeats; Region: HEAT_2; pfam13646 246197017853 HEAT repeats; Region: HEAT_2; pfam13646 246197017854 Peptidase family M23; Region: Peptidase_M23; pfam01551 246197017855 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 246197017856 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 246197017857 active site 246197017858 metal binding site [ion binding]; metal-binding site 246197017859 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 246197017860 dimer interface [polypeptide binding]; other site 246197017861 catalytic triad [active] 246197017862 peroxidatic and resolving cysteines [active] 246197017863 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 246197017864 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 246197017865 nucleotide binding site [chemical binding]; other site 246197017866 Predicted flavoprotein [General function prediction only]; Region: COG0431 246197017867 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 246197017868 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 246197017869 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 246197017870 active site 246197017871 substrate binding site [chemical binding]; other site 246197017872 metal binding site [ion binding]; metal-binding site 246197017873 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197017874 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197017875 active site 246197017876 ATP binding site [chemical binding]; other site 246197017877 substrate binding site [chemical binding]; other site 246197017878 activation loop (A-loop); other site 246197017879 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 246197017880 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 246197017881 Substrate binding site; other site 246197017882 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 246197017883 active site 246197017884 oxyanion hole [active] 246197017885 catalytic triad [active] 246197017886 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 246197017887 SGNH_peri1; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri1; cd01825 246197017888 active site 246197017889 catalytic triad [active] 246197017890 oxyanion hole [active] 246197017891 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 246197017892 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 246197017893 Predicted membrane protein [Function unknown]; Region: COG4325 246197017894 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 246197017895 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 246197017896 Sulfate transporter family; Region: Sulfate_transp; pfam00916 246197017897 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 246197017898 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 246197017899 high affinity sulphate transporter 1; Region: sulP; TIGR00815 246197017900 Sulfate transporter family; Region: Sulfate_transp; pfam00916 246197017901 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 246197017902 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 246197017903 Sulfatase; Region: Sulfatase; pfam00884 246197017904 Uncharacterized conserved protein [Function unknown]; Region: COG2966 246197017905 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 246197017906 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 246197017907 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 246197017908 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 246197017909 putative active site [active] 246197017910 putative CoA binding site [chemical binding]; other site 246197017911 nudix motif; other site 246197017912 metal binding site [ion binding]; metal-binding site 246197017913 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 246197017914 hypothetical protein; Provisional; Region: PRK01842 246197017915 SEC-C motif; Region: SEC-C; pfam02810 246197017916 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 246197017917 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 246197017918 homotetramer interface [polypeptide binding]; other site 246197017919 ligand binding site [chemical binding]; other site 246197017920 catalytic site [active] 246197017921 NAD binding site [chemical binding]; other site 246197017922 S-adenosylmethionine synthetase; Validated; Region: PRK05250 246197017923 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 246197017924 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 246197017925 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 246197017926 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 246197017927 Site-specific recombinase; Region: SpecificRecomb; pfam10136 246197017928 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 246197017929 MgtC family; Region: MgtC; pfam02308 246197017930 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 246197017931 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 246197017932 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 246197017933 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 246197017934 Protein of unknown function (DUF1826); Region: DUF1826; pfam08856 246197017935 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 246197017936 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 246197017937 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 246197017938 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 246197017939 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 246197017940 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 246197017941 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 246197017942 dimerization domain swap beta strand [polypeptide binding]; other site 246197017943 regulatory protein interface [polypeptide binding]; other site 246197017944 active site 246197017945 regulatory phosphorylation site [posttranslational modification]; other site 246197017946 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 246197017947 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 246197017948 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 246197017949 active site 246197017950 phosphorylation site [posttranslational modification] 246197017951 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 246197017952 active pocket/dimerization site; other site 246197017953 active site 246197017954 phosphorylation site [posttranslational modification] 246197017955 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 246197017956 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 246197017957 catalytic triad [active] 246197017958 NADH kinase; Region: PLN02929 246197017959 SPFH domain / Band 7 family; Region: Band_7; pfam01145 246197017960 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 246197017961 putative active site [active] 246197017962 putative metal binding site [ion binding]; other site 246197017963 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246197017964 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197017965 active site 246197017966 ATP binding site [chemical binding]; other site 246197017967 substrate binding site [chemical binding]; other site 246197017968 activation loop (A-loop); other site 246197017969 PEGA domain; Region: PEGA; pfam08308 246197017970 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 246197017971 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 246197017972 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 246197017973 non-specific DNA interactions [nucleotide binding]; other site 246197017974 DNA binding site [nucleotide binding] 246197017975 sequence specific DNA binding site [nucleotide binding]; other site 246197017976 putative cAMP binding site [chemical binding]; other site 246197017977 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 246197017978 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 246197017979 nucleotide binding site [chemical binding]; other site 246197017980 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 246197017981 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 246197017982 active site 246197017983 catalytic residues [active] 246197017984 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 246197017985 substrate binding site [chemical binding]; other site 246197017986 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 246197017987 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 246197017988 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246197017989 dimer interface [polypeptide binding]; other site 246197017990 conserved gate region; other site 246197017991 putative PBP binding loops; other site 246197017992 ABC-ATPase subunit interface; other site 246197017993 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 246197017994 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246197017995 dimer interface [polypeptide binding]; other site 246197017996 conserved gate region; other site 246197017997 putative PBP binding loops; other site 246197017998 ABC-ATPase subunit interface; other site 246197017999 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 246197018000 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 246197018001 Walker A/P-loop; other site 246197018002 ATP binding site [chemical binding]; other site 246197018003 Q-loop/lid; other site 246197018004 ABC transporter signature motif; other site 246197018005 Walker B; other site 246197018006 D-loop; other site 246197018007 H-loop/switch region; other site 246197018008 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 246197018009 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 246197018010 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 246197018011 Walker A/P-loop; other site 246197018012 ATP binding site [chemical binding]; other site 246197018013 Q-loop/lid; other site 246197018014 ABC transporter signature motif; other site 246197018015 Walker B; other site 246197018016 D-loop; other site 246197018017 H-loop/switch region; other site 246197018018 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 246197018019 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 246197018020 beta-galactosidase; Region: BGL; TIGR03356 246197018021 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 246197018022 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197018023 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197018024 active site 246197018025 ATP binding site [chemical binding]; other site 246197018026 substrate binding site [chemical binding]; other site 246197018027 activation loop (A-loop); other site 246197018028 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 246197018029 binding surface 246197018030 Tetratricopeptide repeat; Region: TPR_12; pfam13424 246197018031 TPR motif; other site 246197018032 Tetratricopeptide repeat; Region: TPR_12; pfam13424 246197018033 Tetratricopeptide repeat; Region: TPR_12; pfam13424 246197018034 Tetratricopeptide repeat; Region: TPR_12; pfam13424 246197018035 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197018036 binding surface 246197018037 TPR motif; other site 246197018038 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971 246197018039 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 246197018040 AAA domain; Region: AAA_18; pfam13238 246197018041 HPr kinase/phosphorylase; Provisional; Region: PRK05428 246197018042 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 246197018043 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 246197018044 Hpr binding site; other site 246197018045 active site 246197018046 homohexamer subunit interaction site [polypeptide binding]; other site 246197018047 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 246197018048 nucleotide binding site/active site [active] 246197018049 HIT family signature motif; other site 246197018050 catalytic residue [active] 246197018051 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 246197018052 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 246197018053 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 246197018054 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 246197018055 Walker A/P-loop; other site 246197018056 ATP binding site [chemical binding]; other site 246197018057 Q-loop/lid; other site 246197018058 ABC transporter signature motif; other site 246197018059 Walker B; other site 246197018060 D-loop; other site 246197018061 H-loop/switch region; other site 246197018062 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197018063 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197018064 active site 246197018065 ATP binding site [chemical binding]; other site 246197018066 substrate binding site [chemical binding]; other site 246197018067 activation loop (A-loop); other site 246197018068 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246197018069 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 246197018070 phosphopeptide binding site; other site 246197018071 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 246197018072 cyclase homology domain; Region: CHD; cd07302 246197018073 nucleotidyl binding site; other site 246197018074 metal binding site [ion binding]; metal-binding site 246197018075 dimer interface [polypeptide binding]; other site 246197018076 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 246197018077 iron-sulfur cluster [ion binding]; other site 246197018078 [2Fe-2S] cluster binding site [ion binding]; other site 246197018079 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 246197018080 ABC-ATPase subunit interface; other site 246197018081 dimer interface [polypeptide binding]; other site 246197018082 putative PBP binding regions; other site 246197018083 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 246197018084 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 246197018085 intersubunit interface [polypeptide binding]; other site 246197018086 Stigma-specific protein, Stig1; Region: Stig1; pfam04885 246197018087 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 246197018088 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 246197018089 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 246197018090 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 246197018091 phosphopeptide binding site; other site 246197018092 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 246197018093 Uncharacterized conserved protein [Function unknown]; Region: COG3287 246197018094 FIST N domain; Region: FIST; pfam08495 246197018095 FIST C domain; Region: FIST_C; pfam10442 246197018096 PAS fold; Region: PAS_7; pfam12860 246197018097 PAS domain; Region: PAS_9; pfam13426 246197018098 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246197018099 putative active site [active] 246197018100 heme pocket [chemical binding]; other site 246197018101 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 246197018102 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 246197018103 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197018104 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197018105 dimer interface [polypeptide binding]; other site 246197018106 phosphorylation site [posttranslational modification] 246197018107 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197018108 ATP binding site [chemical binding]; other site 246197018109 Mg2+ binding site [ion binding]; other site 246197018110 G-X-G motif; other site 246197018111 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 246197018112 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 246197018113 Peptidase family C69; Region: Peptidase_C69; cl17793 246197018114 NAD:arginine ADP-ribosyltransferase; Region: ART; pfam01129 246197018115 MarR family; Region: MarR_2; pfam12802 246197018116 Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; Region: SPEC; cl02488 246197018117 linker region; other site 246197018118 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 246197018119 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 246197018120 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 246197018121 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 246197018122 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 246197018123 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 246197018124 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 246197018125 catalytic residues [active] 246197018126 Myxococcus xanthus paralogous domain TIGR02266; Region: gmx_TIGR02266 246197018127 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 246197018128 MreB/Mbl protein; Region: MreB_Mbl; pfam06723 246197018129 nucleotide binding site [chemical binding]; other site 246197018130 putative NEF/HSP70 interaction site [polypeptide binding]; other site 246197018131 SBD interface [polypeptide binding]; other site 246197018132 YceG-like family; Region: YceG; pfam02618 246197018133 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 246197018134 dimerization interface [polypeptide binding]; other site 246197018135 enoyl-CoA hydratase; Provisional; Region: PRK09245 246197018136 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246197018137 substrate binding site [chemical binding]; other site 246197018138 oxyanion hole (OAH) forming residues; other site 246197018139 trimer interface [polypeptide binding]; other site 246197018140 MoxR-like ATPases [General function prediction only]; Region: COG0714 246197018141 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197018142 Walker A motif; other site 246197018143 ATP binding site [chemical binding]; other site 246197018144 Walker B motif; other site 246197018145 arginine finger; other site 246197018146 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 246197018147 Protein of unknown function DUF58; Region: DUF58; pfam01882 246197018148 von Willebrand factor type A domain; Region: VWA_2; pfam13519 246197018149 metal ion-dependent adhesion site (MIDAS); other site 246197018150 N-terminal double-transmembrane domain; Region: two_anch; TIGR02226 246197018151 von Willebrand factor type A domain; Region: VWA_2; pfam13519 246197018152 CARDB; Region: CARDB; pfam07705 246197018153 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 246197018154 antimicrobial peptide, SdpC family; Region: toxin_SdpC; TIGR04032 246197018155 antimicrobial peptide system protein, SdpA family; Region: export_SdpA; TIGR04034 246197018156 antimicrobial peptide system protein, SdpB family; Region: export_SdpB; TIGR04033 246197018157 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 246197018158 G1 box; other site 246197018159 GTP/Mg2+ binding site [chemical binding]; other site 246197018160 G2 box; other site 246197018161 Switch I region; other site 246197018162 G3 box; other site 246197018163 Switch II region; other site 246197018164 G4 box; other site 246197018165 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 246197018166 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 246197018167 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 246197018168 ATP binding site [chemical binding]; other site 246197018169 Mg++ binding site [ion binding]; other site 246197018170 motif III; other site 246197018171 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246197018172 nucleotide binding region [chemical binding]; other site 246197018173 ATP-binding site [chemical binding]; other site 246197018174 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 246197018175 circadian clock protein KaiC; Reviewed; Region: PRK09302 246197018176 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 246197018177 Walker A motif; other site 246197018178 ATP binding site [chemical binding]; other site 246197018179 Walker B motif; other site 246197018180 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 246197018181 Walker A motif; other site 246197018182 ATP binding site [chemical binding]; other site 246197018183 Walker B motif; other site 246197018184 Response regulator receiver domain; Region: Response_reg; pfam00072 246197018185 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197018186 active site 246197018187 phosphorylation site [posttranslational modification] 246197018188 intermolecular recognition site; other site 246197018189 dimerization interface [polypeptide binding]; other site 246197018190 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 246197018191 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 246197018192 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 246197018193 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 246197018194 catalytic triad [active] 246197018195 Response regulator receiver domain; Region: Response_reg; pfam00072 246197018196 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197018197 active site 246197018198 phosphorylation site [posttranslational modification] 246197018199 intermolecular recognition site; other site 246197018200 dimerization interface [polypeptide binding]; other site 246197018201 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 246197018202 Methyltransferase domain; Region: Methyltransf_23; pfam13489 246197018203 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197018204 S-adenosylmethionine binding site [chemical binding]; other site 246197018205 hypothetical protein; Validated; Region: PRK08238 246197018206 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 246197018207 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 246197018208 FAD binding domain; Region: FAD_binding_4; pfam01565 246197018209 short chain dehydrogenase; Provisional; Region: PRK07102 246197018210 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 246197018211 NAD(P) binding site [chemical binding]; other site 246197018212 active site 246197018213 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 246197018214 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 246197018215 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 246197018216 acyl-CoA synthetase; Validated; Region: PRK09192 246197018217 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 246197018218 acyl-activating enzyme (AAE) consensus motif; other site 246197018219 active site 246197018220 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 246197018221 Phospholipid methyltransferase; Region: PEMT; cl17370 246197018222 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 246197018223 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 246197018224 malonyl-CoA binding site [chemical binding]; other site 246197018225 dimer interface [polypeptide binding]; other site 246197018226 active site 246197018227 product binding site; other site 246197018228 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 246197018229 Bacterial proteins similar to Porphyromonas gingivalis HmuY; Region: HmuY; cd12105 246197018230 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 246197018231 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 246197018232 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246197018233 Walker A/P-loop; other site 246197018234 ATP binding site [chemical binding]; other site 246197018235 Q-loop/lid; other site 246197018236 ABC transporter signature motif; other site 246197018237 Walker B; other site 246197018238 D-loop; other site 246197018239 H-loop/switch region; other site 246197018240 TOBE domain; Region: TOBE; cl01440 246197018241 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 246197018242 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246197018243 dimer interface [polypeptide binding]; other site 246197018244 conserved gate region; other site 246197018245 putative PBP binding loops; other site 246197018246 ABC-ATPase subunit interface; other site 246197018247 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 246197018248 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 246197018249 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 246197018250 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246197018251 putative DNA binding site [nucleotide binding]; other site 246197018252 putative Zn2+ binding site [ion binding]; other site 246197018253 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 246197018254 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 246197018255 protein binding site [polypeptide binding]; other site 246197018256 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 246197018257 protein binding site [polypeptide binding]; other site 246197018258 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 246197018259 putative active site [active] 246197018260 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 246197018261 putative catalytic site [active] 246197018262 putative metal binding site [ion binding]; other site 246197018263 putative phosphate binding site [ion binding]; other site 246197018264 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246197018265 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246197018266 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 246197018267 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 246197018268 prolyl-tRNA synthetase; Provisional; Region: PRK08661 246197018269 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 246197018270 dimer interface [polypeptide binding]; other site 246197018271 motif 1; other site 246197018272 active site 246197018273 motif 2; other site 246197018274 motif 3; other site 246197018275 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 246197018276 anticodon binding site; other site 246197018277 zinc-binding site [ion binding]; other site 246197018278 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 246197018279 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 246197018280 hypothetical protein; Provisional; Region: PRK10030 246197018281 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 246197018282 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 246197018283 Protein metal binding site; Region: Cu-binding_MopE; pfam11617 246197018284 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 246197018285 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197018286 S-adenosylmethionine binding site [chemical binding]; other site 246197018287 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 246197018288 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 246197018289 Walker A/P-loop; other site 246197018290 ATP binding site [chemical binding]; other site 246197018291 Q-loop/lid; other site 246197018292 ABC transporter signature motif; other site 246197018293 Walker B; other site 246197018294 D-loop; other site 246197018295 H-loop/switch region; other site 246197018296 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 246197018297 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 246197018298 Walker A/P-loop; other site 246197018299 ATP binding site [chemical binding]; other site 246197018300 Q-loop/lid; other site 246197018301 ABC transporter signature motif; other site 246197018302 Walker B; other site 246197018303 D-loop; other site 246197018304 H-loop/switch region; other site 246197018305 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 246197018306 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 246197018307 TM-ABC transporter signature motif; other site 246197018308 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 246197018309 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 246197018310 TM-ABC transporter signature motif; other site 246197018311 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 246197018312 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 246197018313 putative ligand binding site [chemical binding]; other site 246197018314 Domain of unknown function (DUF2382); Region: DUF2382; cl01590 246197018315 Domain of unknown function (DUF2382); Region: DUF2382; pfam09557 246197018316 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246197018317 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197018318 active site 246197018319 ATP binding site [chemical binding]; other site 246197018320 substrate binding site [chemical binding]; other site 246197018321 activation loop (A-loop); other site 246197018322 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 246197018323 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 246197018324 nucleotide binding site [chemical binding]; other site 246197018325 GrpE; Region: GrpE; pfam01025 246197018326 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 246197018327 dimer interface [polypeptide binding]; other site 246197018328 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 246197018329 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 246197018330 putative catalytic site [active] 246197018331 putative metal binding site [ion binding]; other site 246197018332 putative phosphate binding site [ion binding]; other site 246197018333 Lamin Tail Domain; Region: LTD; pfam00932 246197018334 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 246197018335 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 246197018336 RHS Repeat; Region: RHS_repeat; pfam05593 246197018337 RHS Repeat; Region: RHS_repeat; pfam05593 246197018338 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 246197018339 RHS Repeat; Region: RHS_repeat; cl11982 246197018340 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 246197018341 RHS Repeat; Region: RHS_repeat; cl11982 246197018342 RHS Repeat; Region: RHS_repeat; pfam05593 246197018343 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 246197018344 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 246197018345 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 246197018346 Receptor L domain; Region: Recep_L_domain; pfam01030 246197018347 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 246197018348 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 246197018349 ligand binding site [chemical binding]; other site 246197018350 flexible hinge region; other site 246197018351 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197018352 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197018353 ATP binding site [chemical binding]; other site 246197018354 Mg2+ binding site [ion binding]; other site 246197018355 G-X-G motif; other site 246197018356 Protein of unknown function DUF111; Region: DUF111; pfam01969 246197018357 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 246197018358 AIR carboxylase; Region: AIRC; smart01001 246197018359 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 246197018360 CheC-like family; Region: CheC; pfam04509 246197018361 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 246197018362 putative binding surface; other site 246197018363 active site 246197018364 P2 response regulator binding domain; Region: P2; pfam07194 246197018365 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 246197018366 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197018367 ATP binding site [chemical binding]; other site 246197018368 Mg2+ binding site [ion binding]; other site 246197018369 G-X-G motif; other site 246197018370 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 246197018371 Response regulator receiver domain; Region: Response_reg; pfam00072 246197018372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197018373 active site 246197018374 phosphorylation site [posttranslational modification] 246197018375 intermolecular recognition site; other site 246197018376 dimerization interface [polypeptide binding]; other site 246197018377 CheW-like domain; Region: CheW; pfam01584 246197018378 Protein of unknown function (DUF419); Region: DUF419; pfam04237 246197018379 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246197018380 dimerization interface [polypeptide binding]; other site 246197018381 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 246197018382 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 246197018383 dimer interface [polypeptide binding]; other site 246197018384 putative CheW interface [polypeptide binding]; other site 246197018385 thiamine monophosphate kinase; Provisional; Region: PRK05731 246197018386 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 246197018387 ATP binding site [chemical binding]; other site 246197018388 dimerization interface [polypeptide binding]; other site 246197018389 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 246197018390 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 246197018391 LabA_like proteins; Region: LabA_like; cd06167 246197018392 putative metal binding site [ion binding]; other site 246197018393 Sensory domain found in PocR; Region: PocR; pfam10114 246197018394 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197018395 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197018396 dimer interface [polypeptide binding]; other site 246197018397 phosphorylation site [posttranslational modification] 246197018398 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197018399 ATP binding site [chemical binding]; other site 246197018400 Mg2+ binding site [ion binding]; other site 246197018401 G-X-G motif; other site 246197018402 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 246197018403 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 246197018404 G1 box; other site 246197018405 GTP/Mg2+ binding site [chemical binding]; other site 246197018406 G2 box; other site 246197018407 Switch I region; other site 246197018408 G3 box; other site 246197018409 Switch II region; other site 246197018410 G4 box; other site 246197018411 G5 box; other site 246197018412 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 246197018413 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246197018414 Coenzyme A binding pocket [chemical binding]; other site 246197018415 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 246197018416 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 246197018417 Walker A motif; other site 246197018418 ATP binding site [chemical binding]; other site 246197018419 Walker B motif; other site 246197018420 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 246197018421 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 246197018422 Walker A motif; other site 246197018423 ATP binding site [chemical binding]; other site 246197018424 Walker B motif; other site 246197018425 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 246197018426 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 246197018427 RecX family; Region: RecX; pfam02631 246197018428 PS-10 peptidase S37; Region: Peptidase_S37; pfam05576 246197018429 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 246197018430 active site 246197018431 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 246197018432 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 246197018433 active site 246197018434 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246197018435 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 246197018436 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 246197018437 N-terminal plug; other site 246197018438 ligand-binding site [chemical binding]; other site 246197018439 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 246197018440 DEAD/DEAH box helicase; Region: DEAD; pfam00270 246197018441 DEAD_2; Region: DEAD_2; pfam06733 246197018442 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 246197018443 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 246197018444 Peptidase family M50; Region: Peptidase_M50; pfam02163 246197018445 active site 246197018446 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 246197018447 putative substrate binding region [chemical binding]; other site 246197018448 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 246197018449 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 246197018450 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246197018451 motif II; other site 246197018452 putative lipid kinase; Reviewed; Region: PRK13057 246197018453 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 246197018454 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197018455 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197018456 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197018457 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197018458 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197018459 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 246197018460 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 246197018461 protein binding site [polypeptide binding]; other site 246197018462 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 246197018463 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 246197018464 EamA-like transporter family; Region: EamA; pfam00892 246197018465 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 246197018466 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 246197018467 putative NAD(P) binding site [chemical binding]; other site 246197018468 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 246197018469 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 246197018470 inhibitor site; inhibition site 246197018471 active site 246197018472 dimer interface [polypeptide binding]; other site 246197018473 catalytic residue [active] 246197018474 class II aldolase/adducin domain protein; Provisional; Region: PRK07090 246197018475 intersubunit interface [polypeptide binding]; other site 246197018476 active site 246197018477 Zn2+ binding site [ion binding]; other site 246197018478 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 246197018479 Ankyrin repeats (many copies); Region: Ank_5; pfam13857 246197018480 Response regulator receiver domain; Region: Response_reg; pfam00072 246197018481 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197018482 active site 246197018483 phosphorylation site [posttranslational modification] 246197018484 intermolecular recognition site; other site 246197018485 dimerization interface [polypeptide binding]; other site 246197018486 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246197018487 PAS domain; Region: PAS_9; pfam13426 246197018488 putative active site [active] 246197018489 heme pocket [chemical binding]; other site 246197018490 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 246197018491 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246197018492 putative active site [active] 246197018493 heme pocket [chemical binding]; other site 246197018494 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197018495 dimer interface [polypeptide binding]; other site 246197018496 phosphorylation site [posttranslational modification] 246197018497 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197018498 ATP binding site [chemical binding]; other site 246197018499 Mg2+ binding site [ion binding]; other site 246197018500 G-X-G motif; other site 246197018501 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 246197018502 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246197018503 dimerization interface [polypeptide binding]; other site 246197018504 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246197018505 dimerization interface [polypeptide binding]; other site 246197018506 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 246197018507 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246197018508 dimerization interface [polypeptide binding]; other site 246197018509 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246197018510 dimerization interface [polypeptide binding]; other site 246197018511 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246197018512 dimerization interface [polypeptide binding]; other site 246197018513 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246197018514 dimerization interface [polypeptide binding]; other site 246197018515 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246197018516 dimerization interface [polypeptide binding]; other site 246197018517 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 246197018518 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246197018519 dimerization interface [polypeptide binding]; other site 246197018520 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246197018521 dimerization interface [polypeptide binding]; other site 246197018522 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 246197018523 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246197018524 dimerization interface [polypeptide binding]; other site 246197018525 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246197018526 dimerization interface [polypeptide binding]; other site 246197018527 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246197018528 dimerization interface [polypeptide binding]; other site 246197018529 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246197018530 dimerization interface [polypeptide binding]; other site 246197018531 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246197018532 dimerization interface [polypeptide binding]; other site 246197018533 GAF domain; Region: GAF_2; pfam13185 246197018534 GAF domain; Region: GAF_3; pfam13492 246197018535 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197018536 dimer interface [polypeptide binding]; other site 246197018537 phosphorylation site [posttranslational modification] 246197018538 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197018539 ATP binding site [chemical binding]; other site 246197018540 Mg2+ binding site [ion binding]; other site 246197018541 G-X-G motif; other site 246197018542 Response regulator receiver domain; Region: Response_reg; pfam00072 246197018543 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197018544 active site 246197018545 phosphorylation site [posttranslational modification] 246197018546 intermolecular recognition site; other site 246197018547 dimerization interface [polypeptide binding]; other site 246197018548 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197018549 phosphorylation site [posttranslational modification] 246197018550 intermolecular recognition site; other site 246197018551 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 246197018552 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197018553 active site 246197018554 phosphorylation site [posttranslational modification] 246197018555 intermolecular recognition site; other site 246197018556 dimerization interface [polypeptide binding]; other site 246197018557 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197018558 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 246197018559 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 246197018560 basic region leucin zipper; Region: BRLZ; smart00338 246197018561 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 246197018562 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 246197018563 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 246197018564 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 246197018565 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 246197018566 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 246197018567 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 246197018568 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246197018569 NAD(P) binding site [chemical binding]; other site 246197018570 active site 246197018571 TPR repeat; Region: TPR_11; pfam13414 246197018572 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197018573 binding surface 246197018574 TPR motif; other site 246197018575 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197018576 binding surface 246197018577 Tetratricopeptide repeat; Region: TPR_16; pfam13432 246197018578 TPR motif; other site 246197018579 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246197018580 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246197018581 DNA binding residues [nucleotide binding] 246197018582 dimerization interface [polypeptide binding]; other site 246197018583 Catalytic domain, repeat 1, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_1; cd09140 246197018584 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 246197018585 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 246197018586 putative active site [active] 246197018587 putative active site [active] 246197018588 catalytic site [active] 246197018589 catalytic site [active] 246197018590 Catalytic domain, repeat 2, of uncharacterized bacterial proteins with similarity to vertebrate phospholipases, PLD1 and PLD2; Region: PLDc_vPLD1_2_like_bac_2; cd09143 246197018591 putative active site [active] 246197018592 catalytic site [active] 246197018593 Putative zinc-finger; Region: zf-HC2; pfam13490 246197018594 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 246197018595 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246197018596 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246197018597 DNA binding residues [nucleotide binding] 246197018598 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 246197018599 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 246197018600 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 246197018601 Esterase/lipase [General function prediction only]; Region: COG1647 246197018602 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 246197018603 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 246197018604 Walker A/P-loop; other site 246197018605 ATP binding site [chemical binding]; other site 246197018606 Q-loop/lid; other site 246197018607 ABC transporter signature motif; other site 246197018608 Walker B; other site 246197018609 D-loop; other site 246197018610 H-loop/switch region; other site 246197018611 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 246197018612 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 246197018613 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 246197018614 FtsX-like permease family; Region: FtsX; pfam02687 246197018615 Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143 246197018616 glycerol kinase; Provisional; Region: glpK; PRK00047 246197018617 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 246197018618 N- and C-terminal domain interface [polypeptide binding]; other site 246197018619 active site 246197018620 MgATP binding site [chemical binding]; other site 246197018621 catalytic site [active] 246197018622 metal binding site [ion binding]; metal-binding site 246197018623 glycerol binding site [chemical binding]; other site 246197018624 homotetramer interface [polypeptide binding]; other site 246197018625 homodimer interface [polypeptide binding]; other site 246197018626 FBP binding site [chemical binding]; other site 246197018627 protein IIAGlc interface [polypeptide binding]; other site 246197018628 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 246197018629 aromatic arch; other site 246197018630 DCoH dimer interaction site [polypeptide binding]; other site 246197018631 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 246197018632 DCoH tetramer interaction site [polypeptide binding]; other site 246197018633 substrate binding site [chemical binding]; other site 246197018634 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 246197018635 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 246197018636 metal binding site [ion binding]; metal-binding site 246197018637 putative dimer interface [polypeptide binding]; other site 246197018638 anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451 246197018639 Putative zinc-finger; Region: zf-HC2; pfam13490 246197018640 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 246197018641 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 246197018642 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 246197018643 putative trimer interface [polypeptide binding]; other site 246197018644 putative CoA binding site [chemical binding]; other site 246197018645 Rdx family; Region: Rdx; pfam10262 246197018646 tyrosine decarboxylase; Region: PLN02880 246197018647 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 246197018648 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 246197018649 catalytic residue [active] 246197018650 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 246197018651 Ligand binding site; other site 246197018652 Putative Catalytic site; other site 246197018653 DXD motif; other site 246197018654 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 246197018655 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 246197018656 TrkA-C domain; Region: TrkA_C; pfam02080 246197018657 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 246197018658 rod shape-determining protein MreB; Provisional; Region: PRK13927 246197018659 MreB and similar proteins; Region: MreB_like; cd10225 246197018660 nucleotide binding site [chemical binding]; other site 246197018661 Mg binding site [ion binding]; other site 246197018662 putative protofilament interaction site [polypeptide binding]; other site 246197018663 RodZ interaction site [polypeptide binding]; other site 246197018664 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 246197018665 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 246197018666 C-terminal domain interface [polypeptide binding]; other site 246197018667 GSH binding site (G-site) [chemical binding]; other site 246197018668 dimer interface [polypeptide binding]; other site 246197018669 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 246197018670 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 246197018671 putative NAD(P) binding site [chemical binding]; other site 246197018672 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246197018673 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246197018674 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_6; cd08475 246197018675 putative effector binding pocket; other site 246197018676 putative dimerization interface [polypeptide binding]; other site 246197018677 Domain of unknown function (DUF378); Region: DUF378; pfam04070 246197018678 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 246197018679 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246197018680 non-specific DNA binding site [nucleotide binding]; other site 246197018681 salt bridge; other site 246197018682 sequence-specific DNA binding site [nucleotide binding]; other site 246197018683 Uncharacterized conserved protein [Function unknown]; Region: COG4748 246197018684 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 246197018685 phosphoenolpyruvate synthase; Validated; Region: PRK06464 246197018686 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 246197018687 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 246197018688 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 246197018689 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 246197018690 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 246197018691 tetramer interface [polypeptide binding]; other site 246197018692 catalytic Zn binding site [ion binding]; other site 246197018693 NADP binding site [chemical binding]; other site 246197018694 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_3; cd13148 246197018695 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 246197018696 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 246197018697 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 246197018698 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 246197018699 RNA binding surface [nucleotide binding]; other site 246197018700 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246197018701 Predicted peptidase [General function prediction only]; Region: COG4099 246197018702 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 246197018703 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 246197018704 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 246197018705 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 246197018706 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 246197018707 Biofilm formation and stress response factor; Region: BsmA; pfam10014 246197018708 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 246197018709 Cytochrome c [Energy production and conversion]; Region: COG3258 246197018710 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 246197018711 Peptidase family M1; Region: Peptidase_M1; pfam01433 246197018712 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 246197018713 Zn binding site [ion binding]; other site 246197018714 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 246197018715 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 246197018716 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 246197018717 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 246197018718 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 246197018719 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 246197018720 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246197018721 Walker A/P-loop; other site 246197018722 ATP binding site [chemical binding]; other site 246197018723 Q-loop/lid; other site 246197018724 ABC transporter signature motif; other site 246197018725 Walker B; other site 246197018726 D-loop; other site 246197018727 H-loop/switch region; other site 246197018728 TAP-like protein; Region: Abhydrolase_4; pfam08386 246197018729 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 246197018730 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 246197018731 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 246197018732 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 246197018733 tetramerization interface [polypeptide binding]; other site 246197018734 active site 246197018735 EcsC protein family; Region: EcsC; pfam12787 246197018736 Transcriptional regulators [Transcription]; Region: MarR; COG1846 246197018737 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 246197018738 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 246197018739 putative catalytic site [active] 246197018740 putative metal binding site [ion binding]; other site 246197018741 putative phosphate binding site [ion binding]; other site 246197018742 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14951 246197018743 Bacterial Ig-like domain; Region: Big_5; pfam13205 246197018744 metabolite-proton symporter; Region: 2A0106; TIGR00883 246197018745 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246197018746 putative substrate translocation pore; other site 246197018747 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 246197018748 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 246197018749 ligand binding site [chemical binding]; other site 246197018750 flexible hinge region; other site 246197018751 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 246197018752 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 246197018753 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 246197018754 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 246197018755 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 246197018756 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 246197018757 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197018758 active site 246197018759 phosphorylation site [posttranslational modification] 246197018760 intermolecular recognition site; other site 246197018761 dimerization interface [polypeptide binding]; other site 246197018762 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197018763 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197018764 dimer interface [polypeptide binding]; other site 246197018765 phosphorylation site [posttranslational modification] 246197018766 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197018767 ATP binding site [chemical binding]; other site 246197018768 Mg2+ binding site [ion binding]; other site 246197018769 G-X-G motif; other site 246197018770 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 246197018771 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 246197018772 catalytic residues [active] 246197018773 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 246197018774 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 246197018775 NAD synthetase; Provisional; Region: PRK13981 246197018776 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 246197018777 multimer interface [polypeptide binding]; other site 246197018778 active site 246197018779 catalytic triad [active] 246197018780 protein interface 1 [polypeptide binding]; other site 246197018781 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 246197018782 homodimer interface [polypeptide binding]; other site 246197018783 NAD binding pocket [chemical binding]; other site 246197018784 ATP binding pocket [chemical binding]; other site 246197018785 Mg binding site [ion binding]; other site 246197018786 active-site loop [active] 246197018787 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 246197018788 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 246197018789 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 246197018790 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246197018791 MASE1; Region: MASE1; pfam05231 246197018792 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246197018793 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 246197018794 putative active site [active] 246197018795 heme pocket [chemical binding]; other site 246197018796 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197018797 phosphorylation site [posttranslational modification] 246197018798 dimer interface [polypeptide binding]; other site 246197018799 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197018800 ATP binding site [chemical binding]; other site 246197018801 Mg2+ binding site [ion binding]; other site 246197018802 G-X-G motif; other site 246197018803 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 246197018804 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197018805 active site 246197018806 phosphorylation site [posttranslational modification] 246197018807 intermolecular recognition site; other site 246197018808 dimerization interface [polypeptide binding]; other site 246197018809 TM2 domain; Region: TM2; cl00984 246197018810 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 246197018811 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 246197018812 TPR motif; other site 246197018813 binding surface 246197018814 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 246197018815 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 246197018816 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 246197018817 motif II; other site 246197018818 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 246197018819 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 246197018820 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 246197018821 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 246197018822 methionine sulfoxide reductase B; Provisional; Region: PRK00222 246197018823 bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550 246197018824 methionine sulfoxide reductase A; Provisional; Region: PRK14054 246197018825 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 246197018826 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246197018827 putative active site [active] 246197018828 heme pocket [chemical binding]; other site 246197018829 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197018830 dimer interface [polypeptide binding]; other site 246197018831 phosphorylation site [posttranslational modification] 246197018832 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197018833 ATP binding site [chemical binding]; other site 246197018834 Mg2+ binding site [ion binding]; other site 246197018835 G-X-G motif; other site 246197018836 GAF domain; Region: GAF; cl17456 246197018837 PAS fold; Region: PAS_4; pfam08448 246197018838 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246197018839 putative active site [active] 246197018840 heme pocket [chemical binding]; other site 246197018841 PAS domain S-box; Region: sensory_box; TIGR00229 246197018842 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246197018843 putative active site [active] 246197018844 heme pocket [chemical binding]; other site 246197018845 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197018846 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197018847 dimer interface [polypeptide binding]; other site 246197018848 phosphorylation site [posttranslational modification] 246197018849 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 246197018850 Right handed beta helix region; Region: Beta_helix; pfam13229 246197018851 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 246197018852 active site 246197018853 malonic semialdehyde reductase; Provisional; Region: PRK10538 246197018854 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246197018855 NAD(P) binding site [chemical binding]; other site 246197018856 active site 246197018857 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 246197018858 putative active site [active] 246197018859 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E); Region: PHA_synth_III_E; cl09914 246197018860 poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836 246197018861 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 246197018862 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 246197018863 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 246197018864 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 246197018865 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 246197018866 classical (c) SDRs; Region: SDR_c; cd05233 246197018867 NAD(P) binding site [chemical binding]; other site 246197018868 active site 246197018869 Dihydroneopterin aldolase; Region: FolB; pfam02152 246197018870 active site 246197018871 Cupin domain; Region: Cupin_2; cl17218 246197018872 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246197018873 pteridine reductase; Provisional; Region: PRK09135 246197018874 NAD(P) binding site [chemical binding]; other site 246197018875 active site 246197018876 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197018877 S-adenosylmethionine binding site [chemical binding]; other site 246197018878 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 246197018879 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 246197018880 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 246197018881 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 246197018882 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 246197018883 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 246197018884 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 246197018885 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 246197018886 DNA binding residues [nucleotide binding] 246197018887 dimerization interface [polypeptide binding]; other site 246197018888 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 246197018889 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 246197018890 active site 246197018891 metal binding site [ion binding]; metal-binding site 246197018892 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 246197018893 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 246197018894 catalytic residues [active] 246197018895 Dynamin family; Region: Dynamin_N; pfam00350 246197018896 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 246197018897 G1 box; other site 246197018898 GTP/Mg2+ binding site [chemical binding]; other site 246197018899 G2 box; other site 246197018900 Switch I region; other site 246197018901 G3 box; other site 246197018902 Switch II region; other site 246197018903 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 246197018904 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 246197018905 ligand binding site [chemical binding]; other site 246197018906 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 246197018907 Protein of unknown function, DUF393; Region: DUF393; pfam04134 246197018908 Lipase maturation factor; Region: LMF1; pfam06762 246197018909 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 246197018910 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 246197018911 Amidinotransferase; Region: Amidinotransf; cl12043 246197018912 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 246197018913 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 246197018914 Dynamin family; Region: Dynamin_N; pfam00350 246197018915 G1 box; other site 246197018916 G1 box; other site 246197018917 GTP/Mg2+ binding site [chemical binding]; other site 246197018918 GTP/Mg2+ binding site [chemical binding]; other site 246197018919 G2 box; other site 246197018920 Switch I region; other site 246197018921 G3 box; other site 246197018922 Switch II region; other site 246197018923 G4 box; other site 246197018924 G5 box; other site 246197018925 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 246197018926 Peptidase family M23; Region: Peptidase_M23; pfam01551 246197018927 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246197018928 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246197018929 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 246197018930 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 246197018931 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 246197018932 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 246197018933 active site 246197018934 dimer interface [polypeptide binding]; other site 246197018935 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 246197018936 dimer interface [polypeptide binding]; other site 246197018937 active site 246197018938 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246197018939 classical (c) SDRs; Region: SDR_c; cd05233 246197018940 NAD(P) binding site [chemical binding]; other site 246197018941 active site 246197018942 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 246197018943 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 246197018944 N-terminal plug; other site 246197018945 ligand-binding site [chemical binding]; other site 246197018946 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 246197018947 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 246197018948 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 246197018949 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 246197018950 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 246197018951 Predicted transcriptional regulator [Transcription]; Region: COG1959 246197018952 Transcriptional regulator; Region: Rrf2; cl17282 246197018953 CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609 246197018954 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246197018955 catalytic loop [active] 246197018956 iron binding site [ion binding]; other site 246197018957 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an N-terminal Iron-Sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible...; Region: FNR_N-term_Iron_sulfur_binding; cd06194 246197018958 FAD binding pocket [chemical binding]; other site 246197018959 FAD binding motif [chemical binding]; other site 246197018960 phosphate binding motif [ion binding]; other site 246197018961 beta-alpha-beta structure motif; other site 246197018962 NAD binding pocket [chemical binding]; other site 246197018963 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 246197018964 apolar tunnel; other site 246197018965 heme binding site [chemical binding]; other site 246197018966 dimerization interface [polypeptide binding]; other site 246197018967 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13446 246197018968 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 246197018969 gamma subunit interface [polypeptide binding]; other site 246197018970 epsilon subunit interface [polypeptide binding]; other site 246197018971 LBP interface [polypeptide binding]; other site 246197018972 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 246197018973 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 246197018974 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 246197018975 alpha subunit interaction interface [polypeptide binding]; other site 246197018976 Walker A motif; other site 246197018977 ATP binding site [chemical binding]; other site 246197018978 Walker B motif; other site 246197018979 inhibitor binding site; inhibition site 246197018980 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 246197018981 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 246197018982 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_1; cd03400 246197018983 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 246197018984 core domain interface [polypeptide binding]; other site 246197018985 delta subunit interface [polypeptide binding]; other site 246197018986 epsilon subunit interface [polypeptide binding]; other site 246197018987 Response regulator receiver domain; Region: Response_reg; pfam00072 246197018988 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197018989 active site 246197018990 phosphorylation site [posttranslational modification] 246197018991 intermolecular recognition site; other site 246197018992 dimerization interface [polypeptide binding]; other site 246197018993 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 246197018994 putative active site [active] 246197018995 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 246197018996 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 246197018997 catalytic residues [active] 246197018998 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 246197018999 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 246197019000 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 246197019001 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 246197019002 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 246197019003 putative active site [active] 246197019004 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 246197019005 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246197019006 Walker A/P-loop; other site 246197019007 ATP binding site [chemical binding]; other site 246197019008 Q-loop/lid; other site 246197019009 ABC transporter signature motif; other site 246197019010 Walker B; other site 246197019011 D-loop; other site 246197019012 H-loop/switch region; other site 246197019013 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246197019014 Ligand Binding Site [chemical binding]; other site 246197019015 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 246197019016 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 246197019017 dimer interface [polypeptide binding]; other site 246197019018 putative CheW interface [polypeptide binding]; other site 246197019019 phytoene desaturase; Region: crtI_fam; TIGR02734 246197019020 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 246197019021 CHASE domain; Region: CHASE; pfam03924 246197019022 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197019023 dimer interface [polypeptide binding]; other site 246197019024 phosphorylation site [posttranslational modification] 246197019025 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 246197019026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197019027 ATP binding site [chemical binding]; other site 246197019028 Mg2+ binding site [ion binding]; other site 246197019029 G-X-G motif; other site 246197019030 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 246197019031 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246197019032 non-specific DNA binding site [nucleotide binding]; other site 246197019033 salt bridge; other site 246197019034 sequence-specific DNA binding site [nucleotide binding]; other site 246197019035 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 246197019036 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 246197019037 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 246197019038 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 246197019039 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 246197019040 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 246197019041 TPR motif; other site 246197019042 CheW-like domain; Region: CheW; pfam01584 246197019043 CHASE3 domain; Region: CHASE3; pfam05227 246197019044 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246197019045 dimerization interface [polypeptide binding]; other site 246197019046 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 246197019047 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 246197019048 dimer interface [polypeptide binding]; other site 246197019049 putative CheW interface [polypeptide binding]; other site 246197019050 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 246197019051 putative binding surface; other site 246197019052 active site 246197019053 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 246197019054 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197019055 ATP binding site [chemical binding]; other site 246197019056 Mg2+ binding site [ion binding]; other site 246197019057 G-X-G motif; other site 246197019058 Response regulator receiver domain; Region: Response_reg; pfam00072 246197019059 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197019060 active site 246197019061 phosphorylation site [posttranslational modification] 246197019062 intermolecular recognition site; other site 246197019063 dimerization interface [polypeptide binding]; other site 246197019064 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 246197019065 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197019066 active site 246197019067 phosphorylation site [posttranslational modification] 246197019068 intermolecular recognition site; other site 246197019069 dimerization interface [polypeptide binding]; other site 246197019070 CheB methylesterase; Region: CheB_methylest; pfam01339 246197019071 PAS fold; Region: PAS_4; pfam08448 246197019072 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246197019073 putative active site [active] 246197019074 heme pocket [chemical binding]; other site 246197019075 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 246197019076 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 246197019077 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197019078 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197019079 dimer interface [polypeptide binding]; other site 246197019080 phosphorylation site [posttranslational modification] 246197019081 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197019082 ATP binding site [chemical binding]; other site 246197019083 Mg2+ binding site [ion binding]; other site 246197019084 G-X-G motif; other site 246197019085 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 246197019086 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 246197019087 TrkA-N domain; Region: TrkA_N; pfam02254 246197019088 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 246197019089 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246197019090 putative active site [active] 246197019091 heme pocket [chemical binding]; other site 246197019092 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197019093 dimer interface [polypeptide binding]; other site 246197019094 phosphorylation site [posttranslational modification] 246197019095 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197019096 ATP binding site [chemical binding]; other site 246197019097 Mg2+ binding site [ion binding]; other site 246197019098 G-X-G motif; other site 246197019099 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197019100 Response regulator receiver domain; Region: Response_reg; pfam00072 246197019101 active site 246197019102 phosphorylation site [posttranslational modification] 246197019103 intermolecular recognition site; other site 246197019104 dimerization interface [polypeptide binding]; other site 246197019105 PilZ domain; Region: PilZ; pfam07238 246197019106 Fatty acid desaturase; Region: FA_desaturase; pfam00487 246197019107 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cd01060 246197019108 putative di-iron ligands [ion binding]; other site 246197019109 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 246197019110 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 246197019111 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197019112 active site 246197019113 phosphorylation site [posttranslational modification] 246197019114 intermolecular recognition site; other site 246197019115 CheB methylesterase; Region: CheB_methylest; pfam01339 246197019116 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 246197019117 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 246197019118 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 246197019119 HEAT repeats; Region: HEAT_2; pfam13646 246197019120 protein binding surface [polypeptide binding]; other site 246197019121 HEAT repeats; Region: HEAT_2; pfam13646 246197019122 HEAT repeats; Region: HEAT_2; pfam13646 246197019123 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 246197019124 dimer interface [polypeptide binding]; other site 246197019125 putative CheW interface [polypeptide binding]; other site 246197019126 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 246197019127 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 246197019128 putative binding surface; other site 246197019129 active site 246197019130 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197019131 ATP binding site [chemical binding]; other site 246197019132 Mg2+ binding site [ion binding]; other site 246197019133 G-X-G motif; other site 246197019134 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 246197019135 Response regulator receiver domain; Region: Response_reg; pfam00072 246197019136 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197019137 active site 246197019138 phosphorylation site [posttranslational modification] 246197019139 intermolecular recognition site; other site 246197019140 dimerization interface [polypeptide binding]; other site 246197019141 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 246197019142 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197019143 active site 246197019144 phosphorylation site [posttranslational modification] 246197019145 intermolecular recognition site; other site 246197019146 dimerization interface [polypeptide binding]; other site 246197019147 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246197019148 PAS fold; Region: PAS_3; pfam08447 246197019149 putative active site [active] 246197019150 heme pocket [chemical binding]; other site 246197019151 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197019152 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197019153 dimer interface [polypeptide binding]; other site 246197019154 phosphorylation site [posttranslational modification] 246197019155 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197019156 ATP binding site [chemical binding]; other site 246197019157 Mg2+ binding site [ion binding]; other site 246197019158 G-X-G motif; other site 246197019159 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 246197019160 metal binding site 2 [ion binding]; metal-binding site 246197019161 putative DNA binding helix; other site 246197019162 metal binding site 1 [ion binding]; metal-binding site 246197019163 dimer interface [polypeptide binding]; other site 246197019164 structural Zn2+ binding site [ion binding]; other site 246197019165 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197019166 active site 246197019167 phosphorylation site [posttranslational modification] 246197019168 intermolecular recognition site; other site 246197019169 dimerization interface [polypeptide binding]; other site 246197019170 PAS fold; Region: PAS_4; pfam08448 246197019171 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197019172 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197019173 dimer interface [polypeptide binding]; other site 246197019174 phosphorylation site [posttranslational modification] 246197019175 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197019176 ATP binding site [chemical binding]; other site 246197019177 Mg2+ binding site [ion binding]; other site 246197019178 G-X-G motif; other site 246197019179 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 246197019180 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 246197019181 putative active site [active] 246197019182 putative metal binding site [ion binding]; other site 246197019183 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 246197019184 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557 246197019185 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 246197019186 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197019187 ATP binding site [chemical binding]; other site 246197019188 Mg2+ binding site [ion binding]; other site 246197019189 G-X-G motif; other site 246197019190 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 246197019191 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197019192 active site 246197019193 phosphorylation site [posttranslational modification] 246197019194 intermolecular recognition site; other site 246197019195 dimerization interface [polypeptide binding]; other site 246197019196 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 246197019197 Tubby C 2; Region: Tub_2; cl02043 246197019198 Methyltransferase domain; Region: Methyltransf_31; pfam13847 246197019199 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197019200 S-adenosylmethionine binding site [chemical binding]; other site 246197019201 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 246197019202 DNA binding residues [nucleotide binding] 246197019203 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 246197019204 putative dimer interface [polypeptide binding]; other site 246197019205 putative metal binding residues [ion binding]; other site 246197019206 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 246197019207 Coenzyme A binding pocket [chemical binding]; other site 246197019208 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 246197019209 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 246197019210 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 246197019211 NAD(P) binding site [chemical binding]; other site 246197019212 catalytic residues [active] 246197019213 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 246197019214 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246197019215 substrate binding site [chemical binding]; other site 246197019216 oxyanion hole (OAH) forming residues; other site 246197019217 trimer interface [polypeptide binding]; other site 246197019218 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 246197019219 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 246197019220 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 246197019221 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 246197019222 dimer interface [polypeptide binding]; other site 246197019223 active site 246197019224 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 246197019225 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246197019226 active site 246197019227 Myxococcus xanthus double-CXXCG motif paralogous family; Region: gmx_para_CXXCG; TIGR02264 246197019228 GLTT repeat (6 copies); Region: GLTT; pfam01744 246197019229 GLTT repeat (6 copies); Region: GLTT; pfam01744 246197019230 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197019231 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197019232 dimer interface [polypeptide binding]; other site 246197019233 phosphorylation site [posttranslational modification] 246197019234 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197019235 ATP binding site [chemical binding]; other site 246197019236 Mg2+ binding site [ion binding]; other site 246197019237 G-X-G motif; other site 246197019238 Domain of unknown function (DUF4394); Region: DUF4394; pfam14339 246197019239 Response regulator receiver domain; Region: Response_reg; pfam00072 246197019240 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197019241 active site 246197019242 phosphorylation site [posttranslational modification] 246197019243 intermolecular recognition site; other site 246197019244 dimerization interface [polypeptide binding]; other site 246197019245 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 246197019246 GAF domain; Region: GAF; pfam01590 246197019247 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 246197019248 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 246197019249 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197019250 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197019251 dimer interface [polypeptide binding]; other site 246197019252 phosphorylation site [posttranslational modification] 246197019253 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197019254 ATP binding site [chemical binding]; other site 246197019255 Mg2+ binding site [ion binding]; other site 246197019256 G-X-G motif; other site 246197019257 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 246197019258 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 246197019259 Cna protein B-type domain; Region: Cna_B_2; pfam13715 246197019260 TonB-dependent Receptor Plug Domain; Region: Plug; pfam07715 246197019261 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246197019262 sequence-specific DNA binding site [nucleotide binding]; other site 246197019263 salt bridge; other site 246197019264 Myxococcales-restricted protein, TIGR02265 family; Region: Mxa_TIGR02265 246197019265 CARDB; Region: CARDB; pfam07705 246197019266 Response regulator receiver domain; Region: Response_reg; pfam00072 246197019267 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197019268 active site 246197019269 phosphorylation site [posttranslational modification] 246197019270 intermolecular recognition site; other site 246197019271 dimerization interface [polypeptide binding]; other site 246197019272 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246197019273 PAS domain; Region: PAS_9; pfam13426 246197019274 putative active site [active] 246197019275 heme pocket [chemical binding]; other site 246197019276 PAS domain; Region: PAS_9; pfam13426 246197019277 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197019278 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197019279 dimer interface [polypeptide binding]; other site 246197019280 phosphorylation site [posttranslational modification] 246197019281 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197019282 ATP binding site [chemical binding]; other site 246197019283 Mg2+ binding site [ion binding]; other site 246197019284 G-X-G motif; other site 246197019285 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197019286 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246197019287 dimerization interface [polypeptide binding]; other site 246197019288 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197019289 dimer interface [polypeptide binding]; other site 246197019290 phosphorylation site [posttranslational modification] 246197019291 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197019292 ATP binding site [chemical binding]; other site 246197019293 Mg2+ binding site [ion binding]; other site 246197019294 G-X-G motif; other site 246197019295 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197019296 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 246197019297 Walker A motif; other site 246197019298 ATP binding site [chemical binding]; other site 246197019299 Walker B motif; other site 246197019300 arginine finger; other site 246197019301 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246197019302 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 246197019303 CRISPR repeat region, Dvulg subtype; GMX_CRISPR01 246197019304 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 246197019305 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 246197019306 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637 246197019307 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cd09689 246197019308 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09642 246197019309 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09651 246197019310 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 246197019311 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 246197019312 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 246197019313 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 246197019314 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 246197019315 Putative esterase; Region: Esterase; pfam00756 246197019316 multidrug efflux protein; Reviewed; Region: PRK01766 246197019317 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 246197019318 cation binding site [ion binding]; other site 246197019319 Beta propeller domain; Region: Beta_propel; pfam09826 246197019320 Response regulator receiver domain; Region: Response_reg; pfam00072 246197019321 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197019322 active site 246197019323 phosphorylation site [posttranslational modification] 246197019324 intermolecular recognition site; other site 246197019325 dimerization interface [polypeptide binding]; other site 246197019326 Myxococcus xanthus paralogous domain TIGR02266; Region: gmx_TIGR02266 246197019327 chaperone protein DnaK; Region: prok_dnaK; TIGR02350 246197019328 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 246197019329 nucleotide binding site [chemical binding]; other site 246197019330 putative NEF/HSP70 interaction site [polypeptide binding]; other site 246197019331 SBD interface [polypeptide binding]; other site 246197019332 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429 246197019333 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 246197019334 PAS fold; Region: PAS_4; pfam08448 246197019335 PAS domain S-box; Region: sensory_box; TIGR00229 246197019336 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246197019337 putative active site [active] 246197019338 heme pocket [chemical binding]; other site 246197019339 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197019340 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197019341 dimer interface [polypeptide binding]; other site 246197019342 phosphorylation site [posttranslational modification] 246197019343 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197019344 ATP binding site [chemical binding]; other site 246197019345 G-X-G motif; other site 246197019346 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 246197019347 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 246197019348 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 246197019349 beta subunit interaction interface [polypeptide binding]; other site 246197019350 Walker A motif; other site 246197019351 ATP binding site [chemical binding]; other site 246197019352 Walker B motif; other site 246197019353 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 246197019354 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 246197019355 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 246197019356 Response regulator receiver domain; Region: Response_reg; pfam00072 246197019357 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197019358 active site 246197019359 phosphorylation site [posttranslational modification] 246197019360 intermolecular recognition site; other site 246197019361 dimerization interface [polypeptide binding]; other site 246197019362 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 246197019363 Ligand binding site; other site 246197019364 metal-binding site 246197019365 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 246197019366 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 246197019367 ligand binding site [chemical binding]; other site 246197019368 Bacterial virulence factor lipase N-terminal; Region: Lipase_bact_N; pfam12262 246197019369 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 246197019370 TPR repeat; Region: TPR_11; pfam13414 246197019371 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197019372 TPR motif; other site 246197019373 binding surface 246197019374 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 246197019375 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 246197019376 ligand binding site [chemical binding]; other site 246197019377 flexible hinge region; other site 246197019378 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 246197019379 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 246197019380 ligand binding site [chemical binding]; other site 246197019381 flexible hinge region; other site 246197019382 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 246197019383 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 246197019384 ligand binding site [chemical binding]; other site 246197019385 flexible hinge region; other site 246197019386 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 246197019387 active site 246197019388 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 246197019389 catalytic tetrad [active] 246197019390 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 246197019391 BNR repeat-like domain; Region: BNR_2; pfam13088 246197019392 Asp-box motif; other site 246197019393 Uncharacterized conserved protein [Function unknown]; Region: COG3391 246197019394 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 246197019395 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 246197019396 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cl00653 246197019397 Active_site [active] 246197019398 Uncharacterized conserved protein (DUF2203); Region: DUF2203; pfam09969 246197019399 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 246197019400 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 246197019401 NmrA-like family; Region: NmrA; pfam05368 246197019402 NADP binding site [chemical binding]; other site 246197019403 active site 246197019404 regulatory binding site [polypeptide binding]; other site 246197019405 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 246197019406 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246197019407 putative substrate translocation pore; other site 246197019408 Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423 246197019409 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 246197019410 GAF domain; Region: GAF; pfam01590 246197019411 PAS fold; Region: PAS_4; pfam08448 246197019412 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246197019413 putative active site [active] 246197019414 heme pocket [chemical binding]; other site 246197019415 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197019416 dimer interface [polypeptide binding]; other site 246197019417 phosphorylation site [posttranslational modification] 246197019418 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 246197019419 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197019420 ATP binding site [chemical binding]; other site 246197019421 Mg2+ binding site [ion binding]; other site 246197019422 G-X-G motif; other site 246197019423 methionine sulfoxide reductase A; Provisional; Region: PRK00058 246197019424 hypothetical protein; Provisional; Region: PRK12378 246197019425 Domain of unknown function (DUF4265); Region: DUF4265; pfam14085 246197019426 Protein of unknown function (DUF962); Region: DUF962; pfam06127 246197019427 Predicted transcriptional regulators [Transcription]; Region: COG1733 246197019428 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246197019429 putative Zn2+ binding site [ion binding]; other site 246197019430 putative DNA binding site [nucleotide binding]; other site 246197019431 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 246197019432 putative FMN binding site [chemical binding]; other site 246197019433 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 246197019434 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 246197019435 active site 246197019436 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 246197019437 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 246197019438 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 246197019439 DNA-binding site [nucleotide binding]; DNA binding site 246197019440 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 246197019441 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246197019442 homodimer interface [polypeptide binding]; other site 246197019443 catalytic residue [active] 246197019444 Protein of unknown function (DUF2917); Region: DUF2917; pfam11142 246197019445 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 246197019446 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 246197019447 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246197019448 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 246197019449 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197019450 S-adenosylmethionine binding site [chemical binding]; other site 246197019451 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197019452 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197019453 active site 246197019454 ATP binding site [chemical binding]; other site 246197019455 substrate binding site [chemical binding]; other site 246197019456 activation loop (A-loop); other site 246197019457 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197019458 TPR motif; other site 246197019459 binding surface 246197019460 Tetratricopeptide repeat; Region: TPR_12; pfam13424 246197019461 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 246197019462 TPR motif; other site 246197019463 binding surface 246197019464 Tetratricopeptide repeat; Region: TPR_12; pfam13424 246197019465 Tetratricopeptide repeat; Region: TPR_12; pfam13424 246197019466 Tetratricopeptide repeat; Region: TPR_12; pfam13424 246197019467 RNA polymerase sigma-70 factor, Myxococcales family 1; Region: Sig-70_gmx1; TIGR03001 246197019468 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 246197019469 active site 246197019470 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 246197019471 Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876 246197019472 putative lipid binding site [chemical binding]; other site 246197019473 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 246197019474 catalytic residues [active] 246197019475 dimer interface [polypeptide binding]; other site 246197019476 5' nucleotidase family; Region: 5_nucleotid; pfam05761 246197019477 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 246197019478 S-formylglutathione hydrolase; Region: PLN02442 246197019479 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 246197019480 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 246197019481 substrate binding site [chemical binding]; other site 246197019482 catalytic Zn binding site [ion binding]; other site 246197019483 NAD binding site [chemical binding]; other site 246197019484 structural Zn binding site [ion binding]; other site 246197019485 dimer interface [polypeptide binding]; other site 246197019486 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 246197019487 putative metal binding site [ion binding]; other site 246197019488 putative homodimer interface [polypeptide binding]; other site 246197019489 putative homotetramer interface [polypeptide binding]; other site 246197019490 putative homodimer-homodimer interface [polypeptide binding]; other site 246197019491 putative allosteric switch controlling residues; other site 246197019492 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 246197019493 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197019494 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 246197019495 Peptidase M3 Thimet oligopeptidase (TOP) also includes neurolysin; Region: M3A_TOP; cd06455 246197019496 active site 246197019497 Zn binding site [ion binding]; other site 246197019498 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 246197019499 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 246197019500 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 246197019501 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 246197019502 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 246197019503 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 246197019504 SCP_PR-1_like: SCP-like extracellular protein domain, PR-1 like subfamily. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal...; Region: SCP_PR-1_like; cd05381 246197019505 SCP_PR-1_like: SCP-like extracellular protein domain, PR-1 like subfamily. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal...; Region: SCP_PR-1_like; cd05381 246197019506 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 246197019507 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 246197019508 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 246197019509 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 246197019510 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 246197019511 parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805 246197019512 conserved hypothetical protein, HNE_0200 family; Region: chp_HNE_0200; TIGR03806 246197019513 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 246197019514 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 246197019515 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 246197019516 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246197019517 dimer interface [polypeptide binding]; other site 246197019518 conserved gate region; other site 246197019519 putative PBP binding loops; other site 246197019520 ABC-ATPase subunit interface; other site 246197019521 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_14; cd13139 246197019522 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 246197019523 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 246197019524 putative trimer interface [polypeptide binding]; other site 246197019525 putative CoA binding site [chemical binding]; other site 246197019526 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 246197019527 putative trimer interface [polypeptide binding]; other site 246197019528 putative CoA binding site [chemical binding]; other site 246197019529 2TM domain; Region: 2TM; pfam13239 246197019530 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 246197019531 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 246197019532 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197019533 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197019534 ATP binding site [chemical binding]; other site 246197019535 Mg2+ binding site [ion binding]; other site 246197019536 G-X-G motif; other site 246197019537 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 246197019538 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 246197019539 [2Fe-2S] cluster binding site [ion binding]; other site 246197019540 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 246197019541 hydrophobic ligand binding site; other site 246197019542 GH3 auxin-responsive promoter; Region: GH3; pfam03321 246197019543 NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779 246197019544 Family description; Region: VCBS; pfam13517 246197019545 Family description; Region: VCBS; pfam13517 246197019546 Family description; Region: VCBS; pfam13517 246197019547 Family description; Region: VCBS; pfam13517 246197019548 Family description; Region: VCBS; pfam13517 246197019549 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 246197019550 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 246197019551 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 246197019552 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 246197019553 conserved hypothetical protein; Region: TIGR02270 246197019554 Competence-damaged protein; Region: CinA; pfam02464 246197019555 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 246197019556 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 246197019557 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 246197019558 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 246197019559 PAS domain; Region: PAS; smart00091 246197019560 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 246197019561 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197019562 ATP binding site [chemical binding]; other site 246197019563 Mg2+ binding site [ion binding]; other site 246197019564 G-X-G motif; other site 246197019565 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 246197019566 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197019567 active site 246197019568 phosphorylation site [posttranslational modification] 246197019569 intermolecular recognition site; other site 246197019570 dimerization interface [polypeptide binding]; other site 246197019571 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197019572 Walker A motif; other site 246197019573 ATP binding site [chemical binding]; other site 246197019574 Walker B motif; other site 246197019575 arginine finger; other site 246197019576 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 246197019577 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 246197019578 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 246197019579 Walker A/P-loop; other site 246197019580 ATP binding site [chemical binding]; other site 246197019581 Q-loop/lid; other site 246197019582 ABC transporter signature motif; other site 246197019583 Walker B; other site 246197019584 D-loop; other site 246197019585 H-loop/switch region; other site 246197019586 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 246197019587 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 246197019588 Walker A/P-loop; other site 246197019589 ATP binding site [chemical binding]; other site 246197019590 Q-loop/lid; other site 246197019591 ABC transporter signature motif; other site 246197019592 Walker B; other site 246197019593 D-loop; other site 246197019594 H-loop/switch region; other site 246197019595 Acidobacterial duplicated orphan permease; Region: ADOP; TIGR03434 246197019596 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 246197019597 FtsX-like permease family; Region: FtsX; pfam02687 246197019598 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 246197019599 FtsX-like permease family; Region: FtsX; pfam02687 246197019600 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 246197019601 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 246197019602 HlyD family secretion protein; Region: HlyD_3; pfam13437 246197019603 malonyl-CoA synthase; Validated; Region: PRK07514 246197019604 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 246197019605 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 246197019606 acyl-activating enzyme (AAE) consensus motif; other site 246197019607 active site 246197019608 AMP binding site [chemical binding]; other site 246197019609 CoA binding site [chemical binding]; other site 246197019610 circadian clock protein KaiC; Reviewed; Region: PRK09302 246197019611 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 246197019612 Walker A motif; other site 246197019613 ATP binding site [chemical binding]; other site 246197019614 Walker B motif; other site 246197019615 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 246197019616 Walker A motif; other site 246197019617 ATP binding site [chemical binding]; other site 246197019618 Walker B motif; other site 246197019619 Response regulator receiver domain; Region: Response_reg; pfam00072 246197019620 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197019621 active site 246197019622 phosphorylation site [posttranslational modification] 246197019623 intermolecular recognition site; other site 246197019624 dimerization interface [polypeptide binding]; other site 246197019625 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 246197019626 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 246197019627 catalytic site [active] 246197019628 putative active site [active] 246197019629 putative substrate binding site [chemical binding]; other site 246197019630 dimer interface [polypeptide binding]; other site 246197019631 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246197019632 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 246197019633 Archease protein family (MTH1598/TM1083); Region: Archease; pfam01951 246197019634 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 246197019635 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 246197019636 active site 246197019637 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 246197019638 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 246197019639 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 246197019640 active site 246197019641 enoyl-CoA hydratase; Provisional; Region: PRK06688 246197019642 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 246197019643 substrate binding site [chemical binding]; other site 246197019644 oxyanion hole (OAH) forming residues; other site 246197019645 trimer interface [polypeptide binding]; other site 246197019646 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 246197019647 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 246197019648 Zn binding site [ion binding]; other site 246197019649 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 246197019650 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 246197019651 putative acyl-acceptor binding pocket; other site 246197019652 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 246197019653 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 246197019654 active site 246197019655 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 246197019656 dimer interface [polypeptide binding]; other site 246197019657 substrate binding site [chemical binding]; other site 246197019658 catalytic residues [active] 246197019659 RNA polymerase sigma-70 factor, Myxococcales family 1; Region: Sig-70_gmx1; TIGR03001 246197019660 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246197019661 DNA binding residues [nucleotide binding] 246197019662 Putative zinc-finger; Region: zf-HC2; pfam13490 246197019663 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197019664 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197019665 active site 246197019666 ATP binding site [chemical binding]; other site 246197019667 substrate binding site [chemical binding]; other site 246197019668 activation loop (A-loop); other site 246197019669 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 246197019670 Tetratricopeptide repeat; Region: TPR_12; pfam13424 246197019671 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197019672 binding surface 246197019673 TPR motif; other site 246197019674 Tetratricopeptide repeat; Region: TPR_12; pfam13424 246197019675 Tetratricopeptide repeat; Region: TPR_12; pfam13424 246197019676 Tetratricopeptide repeat; Region: TPR_12; pfam13424 246197019677 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 246197019678 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 246197019679 active site 246197019680 metal binding site [ion binding]; metal-binding site 246197019681 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246197019682 Ligand Binding Site [chemical binding]; other site 246197019683 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246197019684 Ligand Binding Site [chemical binding]; other site 246197019685 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246197019686 Ligand Binding Site [chemical binding]; other site 246197019687 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 246197019688 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 246197019689 putative ligand binding site [chemical binding]; other site 246197019690 putative NAD binding site [chemical binding]; other site 246197019691 catalytic site [active] 246197019692 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 246197019693 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 246197019694 active site 246197019695 TonB family C-terminal domain; Region: tonB_Cterm; TIGR01352 246197019696 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 246197019697 Beta-lactamase; Region: Beta-lactamase; pfam00144 246197019698 SGNH_peri1; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri1; cd01825 246197019699 active site 246197019700 oxyanion hole [active] 246197019701 catalytic triad [active] 246197019702 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 246197019703 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246197019704 non-specific DNA binding site [nucleotide binding]; other site 246197019705 salt bridge; other site 246197019706 sequence-specific DNA binding site [nucleotide binding]; other site 246197019707 Type II/IV secretion system protein; Region: T2SE; pfam00437 246197019708 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 246197019709 Walker A motif; other site 246197019710 ATP binding site [chemical binding]; other site 246197019711 Walker B motif; other site 246197019712 PEGA domain; Region: PEGA; pfam08308 246197019713 Response regulator receiver domain; Region: Response_reg; pfam00072 246197019714 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197019715 active site 246197019716 phosphorylation site [posttranslational modification] 246197019717 intermolecular recognition site; other site 246197019718 dimerization interface [polypeptide binding]; other site 246197019719 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 246197019720 dimerization interface [polypeptide binding]; other site 246197019721 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197019722 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197019723 dimer interface [polypeptide binding]; other site 246197019724 phosphorylation site [posttranslational modification] 246197019725 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197019726 ATP binding site [chemical binding]; other site 246197019727 Mg2+ binding site [ion binding]; other site 246197019728 G-X-G motif; other site 246197019729 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 246197019730 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246197019731 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 246197019732 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246197019733 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 246197019734 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 246197019735 catalytic triad [active] 246197019736 conserved cis-peptide bond; other site 246197019737 RIO kinase family, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside...; Region: RIO; cl17248 246197019738 ATP binding site [chemical binding]; other site 246197019739 Protein phosphatase 2C; Region: PP2C_2; pfam13672 246197019740 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 246197019741 nudix motif; other site 246197019742 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 246197019743 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 246197019744 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 246197019745 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 246197019746 putative NAD(P) binding site [chemical binding]; other site 246197019747 active site 246197019748 Bacterial Ig-like domain; Region: Big_5; pfam13205 246197019749 Herpesvirus UL25 family; Region: Herpes_UL25; pfam01499 246197019750 PEGA domain; Region: PEGA; pfam08308 246197019751 IgA Peptidase M64; Region: Peptidase_M64; pfam09471 246197019752 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 246197019753 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 246197019754 putative catalytic site [active] 246197019755 putative metal binding site [ion binding]; other site 246197019756 putative phosphate binding site [ion binding]; other site 246197019757 Lamin Tail Domain; Region: LTD; pfam00932 246197019758 Uncharacterized conserved protein [Function unknown]; Region: COG2968 246197019759 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 246197019760 Hemerythrin-like domain; Region: Hr-like; cd12108 246197019761 Fe binding site [ion binding]; other site 246197019762 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 246197019763 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 246197019764 FMN-binding pocket [chemical binding]; other site 246197019765 flavin binding motif; other site 246197019766 phosphate binding motif [ion binding]; other site 246197019767 beta-alpha-beta structure motif; other site 246197019768 NAD binding pocket [chemical binding]; other site 246197019769 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 246197019770 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 246197019771 catalytic loop [active] 246197019772 iron binding site [ion binding]; other site 246197019773 Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292 246197019774 Two component regulator propeller; Region: Reg_prop; pfam07494 246197019775 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 246197019776 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197019777 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197019778 phosphorylation site [posttranslational modification] 246197019779 dimer interface [polypeptide binding]; other site 246197019780 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197019781 ATP binding site [chemical binding]; other site 246197019782 Mg2+ binding site [ion binding]; other site 246197019783 G-X-G motif; other site 246197019784 Response regulator receiver domain; Region: Response_reg; pfam00072 246197019785 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197019786 active site 246197019787 phosphorylation site [posttranslational modification] 246197019788 intermolecular recognition site; other site 246197019789 dimerization interface [polypeptide binding]; other site 246197019790 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197019791 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197019792 active site 246197019793 ATP binding site [chemical binding]; other site 246197019794 substrate binding site [chemical binding]; other site 246197019795 activation loop (A-loop); other site 246197019796 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 246197019797 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 246197019798 active site 246197019799 catalytic residues [active] 246197019800 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538 246197019801 PA/protease or protease-like domain interface [polypeptide binding]; other site 246197019802 Subtilase family; Region: Peptidase_S8; pfam00082 246197019803 catalytic residues [active] 246197019804 Uncharacterized conserved protein (DUF2267); Region: DUF2267; pfam10025 246197019805 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 246197019806 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 246197019807 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246197019808 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246197019809 DNA binding residues [nucleotide binding] 246197019810 Caspase domain; Region: Peptidase_C14; pfam00656 246197019811 Bacterial Ig-like domain; Region: Big_5; pfam13205 246197019812 Bacterial Ig-like domain; Region: Big_5; pfam13205 246197019813 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 246197019814 active site 246197019815 Kelch domain; Region: Kelch; smart00612 246197019816 Kelch motif; Region: Kelch_1; pfam01344 246197019817 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 246197019818 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 246197019819 Kelch motif; Region: Kelch_6; pfam13964 246197019820 Kelch motif; Region: Kelch_6; pfam13964 246197019821 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 246197019822 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 246197019823 Kelch motif; Region: Kelch_6; pfam13964 246197019824 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 246197019825 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 246197019826 Walker A/P-loop; other site 246197019827 ATP binding site [chemical binding]; other site 246197019828 Q-loop/lid; other site 246197019829 ABC transporter signature motif; other site 246197019830 Walker B; other site 246197019831 D-loop; other site 246197019832 H-loop/switch region; other site 246197019833 TOBE domain; Region: TOBE_2; pfam08402 246197019834 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 246197019835 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 246197019836 Walker A/P-loop; other site 246197019837 ATP binding site [chemical binding]; other site 246197019838 Q-loop/lid; other site 246197019839 ABC transporter signature motif; other site 246197019840 Walker B; other site 246197019841 D-loop; other site 246197019842 H-loop/switch region; other site 246197019843 Protein of unknown function (DUF3142); Region: DUF3142; pfam11340 246197019844 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 246197019845 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 246197019846 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 246197019847 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 246197019848 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 246197019849 catalytic site [active] 246197019850 TAP-like protein; Region: Abhydrolase_4; pfam08386 246197019851 AAA domain; Region: AAA_23; pfam13476 246197019852 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246197019853 Walker A/P-loop; other site 246197019854 ATP binding site [chemical binding]; other site 246197019855 AAA domain; Region: AAA_21; pfam13304 246197019856 Necrosis inducing protein (NPP1); Region: NPP1; pfam05630 246197019857 Outer membrane efflux protein; Region: OEP; pfam02321 246197019858 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 246197019859 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 246197019860 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 246197019861 HlyD family secretion protein; Region: HlyD_3; pfam13437 246197019862 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 246197019863 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 246197019864 ligand binding site [chemical binding]; other site 246197019865 flexible hinge region; other site 246197019866 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 246197019867 Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205 246197019868 active site 246197019869 nucleophile elbow; other site 246197019870 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 246197019871 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 246197019872 active site 246197019873 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 246197019874 putative acyl-acceptor binding pocket; other site 246197019875 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 246197019876 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246197019877 NAD(P) binding site [chemical binding]; other site 246197019878 active site 246197019879 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 246197019880 ligand binding site [chemical binding]; other site 246197019881 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 246197019882 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246197019883 ATP binding site [chemical binding]; other site 246197019884 putative Mg++ binding site [ion binding]; other site 246197019885 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246197019886 nucleotide binding region [chemical binding]; other site 246197019887 ATP-binding site [chemical binding]; other site 246197019888 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 246197019889 S-adenosylmethionine binding site [chemical binding]; other site 246197019890 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197019891 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197019892 active site 246197019893 ATP binding site [chemical binding]; other site 246197019894 substrate binding site [chemical binding]; other site 246197019895 activation loop (A-loop); other site 246197019896 AAA ATPase domain; Region: AAA_16; pfam13191 246197019897 Predicted ATPase [General function prediction only]; Region: COG3899 246197019898 Uncharacterized ABC-type transport system, permease components [General function prediction only]; Region: COG3932 246197019899 Myxococcales-restricted protein, TIGR02265 family; Region: Mxa_TIGR02265 246197019900 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 246197019901 NADH(P)-binding; Region: NAD_binding_10; pfam13460 246197019902 NAD(P) binding site [chemical binding]; other site 246197019903 active site 246197019904 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 246197019905 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 246197019906 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 246197019907 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 246197019908 CRISPR repeat region, RAMP subtype; GMX_CRISPR02 246197019909 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 246197019910 CRISPR repeat region, RAMP subtype; GMX_CRISPR03 246197019911 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 246197019912 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 246197019913 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 246197019914 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09688 246197019915 CRISPR-associated autoregulator DevR family; Region: cas_MJ0381; TIGR01875 246197019916 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I; cd09650 246197019917 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09713 246197019918 CRISPR/Cas system-associated protein Cas8c' Region: Cas8c'_I-D; cd09714 246197019919 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 246197019920 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 246197019921 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 246197019922 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 246197019923 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09703 246197019924 Myxococcus xanthus paralogous family TIGR02268; Region: TIGR02268 246197019925 Protein kinase domain; Region: Pkinase; pfam00069 246197019926 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197019927 active site 246197019928 ATP binding site [chemical binding]; other site 246197019929 substrate binding site [chemical binding]; other site 246197019930 activation loop (A-loop); other site 246197019931 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 246197019932 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14954 246197019933 Uncharacterized conserved protein [Function unknown]; Region: COG4279 246197019934 SWIM zinc finger; Region: SWIM; pfam04434 246197019935 SNF2 Helicase protein; Region: DUF3670; pfam12419 246197019936 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 246197019937 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 246197019938 ATP binding site [chemical binding]; other site 246197019939 putative Mg++ binding site [ion binding]; other site 246197019940 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 246197019941 nucleotide binding region [chemical binding]; other site 246197019942 ATP-binding site [chemical binding]; other site 246197019943 CRISPR repeat region, RAMP subtype; GMX_CRISPR04 246197019944 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09703 246197019945 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 246197019946 CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cd09749 246197019947 CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440 246197019948 CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700 246197019949 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cd09748 246197019950 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09679 246197019951 CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577 246197019952 CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436 246197019953 CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436 246197019954 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 246197019955 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 246197019956 ATP binding site [chemical binding]; other site 246197019957 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 246197019958 metal binding triad [ion binding]; metal-binding site 246197019959 CHAT domain; Region: CHAT; cl17868 246197019960 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 246197019961 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246197019962 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 246197019963 DNA binding residues [nucleotide binding] 246197019964 CHAT domain; Region: CHAT; cl17868 246197019965 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 246197019966 active site 246197019967 NTP binding site [chemical binding]; other site 246197019968 metal binding triad [ion binding]; metal-binding site 246197019969 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 246197019970 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246197019971 dimer interface [polypeptide binding]; other site 246197019972 conserved gate region; other site 246197019973 putative PBP binding loops; other site 246197019974 ABC-ATPase subunit interface; other site 246197019975 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 246197019976 dimer interface [polypeptide binding]; other site 246197019977 conserved gate region; other site 246197019978 putative PBP binding loops; other site 246197019979 ABC-ATPase subunit interface; other site 246197019980 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 246197019981 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 246197019982 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 246197019983 Cytochrome P450; Region: p450; cl12078 246197019984 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 246197019985 Fatty acid desaturase; Region: FA_desaturase; pfam00487 246197019986 putative di-iron ligands [ion binding]; other site 246197019987 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 246197019988 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 246197019989 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 246197019990 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 246197019991 Thioredoxin; Region: Thioredoxin_4; pfam13462 246197019992 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 246197019993 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197019994 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197019995 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 246197019996 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 246197019997 non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226 246197019998 Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491 246197019999 MltA specific insert domain; Region: MltA; smart00925 246197020000 3D domain; Region: 3D; pfam06725 246197020001 short chain dehydrogenase; Provisional; Region: PRK08278 246197020002 human hydroxysteroid dehydrogenase-like protein 2 (HSDL2), classical (c) SDRs; Region: HSDL2_SDR_c; cd09762 246197020003 NAD(P) binding site [chemical binding]; other site 246197020004 homodimer interface [polypeptide binding]; other site 246197020005 active site 246197020006 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 246197020007 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 246197020008 active site 246197020009 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246197020010 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246197020011 LysR substrate binding domain; Region: LysR_substrate; pfam03466 246197020012 dimerization interface [polypeptide binding]; other site 246197020013 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 246197020014 Esterase PHB depolymerase; Region: Esterase_phd; pfam10503 246197020015 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 246197020016 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246197020017 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 246197020018 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 246197020019 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 246197020020 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 246197020021 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 246197020022 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 246197020023 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 246197020024 N-acetyl-D-glucosamine binding site [chemical binding]; other site 246197020025 catalytic residue [active] 246197020026 Penicillinase repressor; Region: Pencillinase_R; pfam03965 246197020027 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 246197020028 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 246197020029 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 246197020030 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 246197020031 AAA ATPase domain; Region: AAA_16; pfam13191 246197020032 Transcriptional regulator [Transcription]; Region: LysR; COG0583 246197020033 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 246197020034 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 246197020035 dimerization interface [polypeptide binding]; other site 246197020036 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 246197020037 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 246197020038 putative NAD(P) binding site [chemical binding]; other site 246197020039 putative substrate binding site [chemical binding]; other site 246197020040 catalytic Zn binding site [ion binding]; other site 246197020041 structural Zn binding site [ion binding]; other site 246197020042 dimer interface [polypeptide binding]; other site 246197020043 Acyltransferase family; Region: Acyl_transf_3; pfam01757 246197020044 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 246197020045 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246197020046 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 246197020047 DNA binding residues [nucleotide binding] 246197020048 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 246197020049 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 246197020050 active site 246197020051 catalytic residues [active] 246197020052 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cd00538 246197020053 PA/protease or protease-like domain interface [polypeptide binding]; other site 246197020054 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 246197020055 catalytic residues [active] 246197020056 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 246197020057 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 246197020058 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 246197020059 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 246197020060 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 246197020061 binding surface 246197020062 TPR motif; other site 246197020063 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 246197020064 binding surface 246197020065 Tetratricopeptide repeat; Region: TPR_16; pfam13432 246197020066 TPR motif; other site 246197020067 SlyX; Region: SlyX; pfam04102 246197020068 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 246197020069 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 246197020070 active site 246197020071 catalytic residues [active] 246197020072 metal binding site [ion binding]; metal-binding site 246197020073 SnoaL-like domain; Region: SnoaL_2; pfam12680 246197020074 Myxococcales-restricted protein, TIGR02265 family; Region: Mxa_TIGR02265 246197020075 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 246197020076 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 246197020077 active site 246197020078 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 246197020079 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197020080 Walker A motif; other site 246197020081 ATP binding site [chemical binding]; other site 246197020082 Walker B motif; other site 246197020083 arginine finger; other site 246197020084 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 246197020085 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 246197020086 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 246197020087 TPP-binding site [chemical binding]; other site 246197020088 dimer interface [polypeptide binding]; other site 246197020089 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 246197020090 PYR/PP interface [polypeptide binding]; other site 246197020091 dimer interface [polypeptide binding]; other site 246197020092 TPP binding site [chemical binding]; other site 246197020093 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 246197020094 tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431 246197020095 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 246197020096 RNA binding site [nucleotide binding]; other site 246197020097 active site 246197020098 Uncharacterized conserved protein [Function unknown]; Region: COG5276 246197020099 Uncharacterized conserved protein [Function unknown]; Region: COG5276 246197020100 LVIVD repeat; Region: LVIVD; pfam08309 246197020101 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197020102 Response regulator receiver domain; Region: Response_reg; pfam00072 246197020103 active site 246197020104 phosphorylation site [posttranslational modification] 246197020105 intermolecular recognition site; other site 246197020106 dimerization interface [polypeptide binding]; other site 246197020107 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197020108 active site 246197020109 Response regulator containing a CheY-like receiver domain and a GGDEF domain [Signal transduction mechanisms]; Region: PleD; COG3706 246197020110 phosphorylation site [posttranslational modification] 246197020111 intermolecular recognition site; other site 246197020112 dimerization interface [polypeptide binding]; other site 246197020113 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197020114 active site 246197020115 phosphorylation site [posttranslational modification] 246197020116 intermolecular recognition site; other site 246197020117 dimerization interface [polypeptide binding]; other site 246197020118 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 246197020119 metal binding site [ion binding]; metal-binding site 246197020120 active site 246197020121 I-site; other site 246197020122 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 246197020123 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197020124 dimer interface [polypeptide binding]; other site 246197020125 phosphorylation site [posttranslational modification] 246197020126 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197020127 ATP binding site [chemical binding]; other site 246197020128 Mg2+ binding site [ion binding]; other site 246197020129 G-X-G motif; other site 246197020130 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197020131 active site 246197020132 phosphorylation site [posttranslational modification] 246197020133 intermolecular recognition site; other site 246197020134 dimerization interface [polypeptide binding]; other site 246197020135 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 246197020136 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197020137 active site 246197020138 phosphorylation site [posttranslational modification] 246197020139 intermolecular recognition site; other site 246197020140 dimerization interface [polypeptide binding]; other site 246197020141 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197020142 Response regulator receiver domain; Region: Response_reg; pfam00072 246197020143 active site 246197020144 phosphorylation site [posttranslational modification] 246197020145 intermolecular recognition site; other site 246197020146 dimerization interface [polypeptide binding]; other site 246197020147 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 246197020148 PAS domain S-box; Region: sensory_box; TIGR00229 246197020149 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246197020150 putative active site [active] 246197020151 heme pocket [chemical binding]; other site 246197020152 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197020153 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197020154 ATP binding site [chemical binding]; other site 246197020155 Mg2+ binding site [ion binding]; other site 246197020156 G-X-G motif; other site 246197020157 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 246197020158 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246197020159 non-specific DNA binding site [nucleotide binding]; other site 246197020160 salt bridge; other site 246197020161 sequence-specific DNA binding site [nucleotide binding]; other site 246197020162 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 246197020163 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197020164 active site 246197020165 ATP binding site [chemical binding]; other site 246197020166 substrate binding site [chemical binding]; other site 246197020167 activation loop (A-loop); other site 246197020168 Catalytic domain of Protein Kinases; Region: PKc; cd00180 246197020169 active site 246197020170 ATP binding site [chemical binding]; other site 246197020171 substrate binding site [chemical binding]; other site 246197020172 activation loop (A-loop); other site 246197020173 ornithine--oxo-acid transaminase; Reviewed; Region: rocD; PRK00854 246197020174 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 246197020175 inhibitor-cofactor binding pocket; inhibition site 246197020176 pyridoxal 5'-phosphate binding site [chemical binding]; other site 246197020177 catalytic residue [active] 246197020178 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 246197020179 DTAP/Switch II; other site 246197020180 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 246197020181 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 246197020182 FOG: CBS domain [General function prediction only]; Region: COG0517 246197020183 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 246197020184 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 246197020185 iron-sulfur cluster [ion binding]; other site 246197020186 [2Fe-2S] cluster binding site [ion binding]; other site 246197020187 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 246197020188 iron-sulfur cluster [ion binding]; other site 246197020189 [2Fe-2S] cluster binding site [ion binding]; other site 246197020190 YceI-like domain; Region: YceI; pfam04264 246197020191 SnoaL-like domain; Region: SnoaL_2; pfam12680 246197020192 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 246197020193 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 246197020194 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 246197020195 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 246197020196 Predicted chitinase [General function prediction only]; Region: COG3179 246197020197 catalytic residue [active] 246197020198 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 246197020199 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 246197020200 Cu(I) binding site [ion binding]; other site 246197020201 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246197020202 Ligand Binding Site [chemical binding]; other site 246197020203 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 246197020204 Ligand Binding Site [chemical binding]; other site 246197020205 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 246197020206 Response regulator receiver domain; Region: Response_reg; pfam00072 246197020207 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197020208 active site 246197020209 phosphorylation site [posttranslational modification] 246197020210 intermolecular recognition site; other site 246197020211 dimerization interface [polypeptide binding]; other site 246197020212 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 246197020213 cyclase homology domain; Region: CHD; cd07302 246197020214 nucleotidyl binding site; other site 246197020215 metal binding site [ion binding]; metal-binding site 246197020216 dimer interface [polypeptide binding]; other site 246197020217 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 246197020218 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 246197020219 ligand binding site [chemical binding]; other site 246197020220 GAF domain; Region: GAF; pfam01590 246197020221 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197020222 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197020223 dimer interface [polypeptide binding]; other site 246197020224 phosphorylation site [posttranslational modification] 246197020225 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197020226 ATP binding site [chemical binding]; other site 246197020227 Mg2+ binding site [ion binding]; other site 246197020228 G-X-G motif; other site 246197020229 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 246197020230 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 246197020231 putative acyl-acceptor binding pocket; other site 246197020232 Proline dehydrogenase; Region: Pro_dh; cl03282 246197020233 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 246197020234 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 246197020235 Myxococcales-restricted protein, TIGR02265 family; Region: Mxa_TIGR02265 246197020236 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 246197020237 Protein of unknown function (Gmx_para_CXXCG); Region: Gmx_para_CXXCG; pfam09535 246197020238 Predicted lipoprotein of unknown function (DUF2380); Region: DUF2380; pfam09533 246197020239 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 246197020240 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 246197020241 GTP binding site; other site 246197020242 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 246197020243 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 246197020244 dimer interface [polypeptide binding]; other site 246197020245 putative functional site; other site 246197020246 putative MPT binding site; other site 246197020247 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 246197020248 Walker A motif; other site 246197020249 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 246197020250 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 246197020251 Bacterial sugar transferase; Region: Bac_transf; pfam02397 246197020252 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 246197020253 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 246197020254 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 246197020255 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 246197020256 Response regulator receiver domain; Region: Response_reg; pfam00072 246197020257 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197020258 active site 246197020259 phosphorylation site [posttranslational modification] 246197020260 intermolecular recognition site; other site 246197020261 dimerization interface [polypeptide binding]; other site 246197020262 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 246197020263 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 246197020264 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 246197020265 DXD motif; other site 246197020266 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 246197020267 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 246197020268 Protein of unknown function (DUF2379); Region: DUF2379; pfam09543 246197020269 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 246197020270 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 246197020271 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 246197020272 von Willebrand factor; Region: vWF_A; pfam12450 246197020273 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 246197020274 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 246197020275 metal ion-dependent adhesion site (MIDAS); other site 246197020276 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 246197020277 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 246197020278 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246197020279 Outer membrane efflux protein; Region: OEP; pfam02321 246197020280 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 246197020281 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 246197020282 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 246197020283 HlyD family secretion protein; Region: HlyD_3; pfam13437 246197020284 Stimulus-sensing domain; Region: Stimulus_sens_1; pfam13756 246197020285 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197020286 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 246197020287 dimerization interface [polypeptide binding]; other site 246197020288 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197020289 dimer interface [polypeptide binding]; other site 246197020290 phosphorylation site [posttranslational modification] 246197020291 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197020292 ATP binding site [chemical binding]; other site 246197020293 G-X-G motif; other site 246197020294 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 246197020295 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197020296 active site 246197020297 phosphorylation site [posttranslational modification] 246197020298 intermolecular recognition site; other site 246197020299 dimerization interface [polypeptide binding]; other site 246197020300 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 246197020301 Walker A motif; other site 246197020302 ATP binding site [chemical binding]; other site 246197020303 Walker B motif; other site 246197020304 arginine finger; other site 246197020305 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 246197020306 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 246197020307 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246197020308 O-Antigen ligase; Region: Wzy_C; pfam04932 246197020309 MgtE intracellular N domain; Region: MgtE_N; smart00924 246197020310 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 246197020311 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 246197020312 Divalent cation transporter; Region: MgtE; cl00786 246197020313 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 246197020314 Response regulator receiver domain; Region: Response_reg; pfam00072 246197020315 active site 246197020316 phosphorylation site [posttranslational modification] 246197020317 intermolecular recognition site; other site 246197020318 dimerization interface [polypeptide binding]; other site 246197020319 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 246197020320 PAS fold; Region: PAS_3; pfam08447 246197020321 putative active site [active] 246197020322 heme pocket [chemical binding]; other site 246197020323 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 246197020324 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 246197020325 dimer interface [polypeptide binding]; other site 246197020326 phosphorylation site [posttranslational modification] 246197020327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 246197020328 ATP binding site [chemical binding]; other site 246197020329 Mg2+ binding site [ion binding]; other site 246197020330 G-X-G motif; other site 246197020331 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 246197020332 putative ADP-binding pocket [chemical binding]; other site 246197020333 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 246197020334 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 246197020335 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 246197020336 active site 246197020337 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 246197020338 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 246197020339 trimer interface [polypeptide binding]; other site 246197020340 active site 246197020341 substrate binding site [chemical binding]; other site 246197020342 CoA binding site [chemical binding]; other site 246197020343 Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891 246197020344 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 246197020345 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 246197020346 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412 246197020347 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 246197020348 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 246197020349 Granulin; Region: Granulin; pfam00396 246197020350 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 246197020351 Interdomain contacts; other site 246197020352 Cytokine receptor motif; other site 246197020353 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 246197020354 Interdomain contacts; other site 246197020355 Cytokine receptor motif; other site 246197020356 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 246197020357 Interdomain contacts; other site 246197020358 Cytokine receptor motif; other site 246197020359 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 246197020360 Interdomain contacts; other site 246197020361 Cytokine receptor motif; other site 246197020362 Family description; Region: VCBS; pfam13517 246197020363 Family description; Region: VCBS; pfam13517 246197020364 Family description; Region: VCBS; pfam13517 246197020365 Family description; Region: VCBS; pfam13517 246197020366 Family description; Region: VCBS; pfam13517 246197020367 Family description; Region: VCBS; pfam13517 246197020368 Family description; Region: VCBS; pfam13517 246197020369 Family description; Region: VCBS; pfam13517 246197020370 Family description; Region: VCBS; pfam13517 246197020371 Methyltransferase domain; Region: Methyltransf_26; pfam13659 246197020372 S-adenosylmethionine binding site [chemical binding]; other site 246197020373 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 246197020374 Domain of unknown function (DUF4326); Region: DUF4326; pfam14216 246197020375 alanine dehydrogenase; Validated; Region: PRK06046 246197020376 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 246197020377 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 246197020378 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 246197020379 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 246197020380 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 246197020381 Cl- selectivity filter; other site 246197020382 Cl- binding residues [ion binding]; other site 246197020383 pore gating glutamate residue; other site 246197020384 dimer interface [polypeptide binding]; other site 246197020385 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 246197020386 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 246197020387 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 246197020388 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 246197020389 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 246197020390 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 246197020391 non-specific DNA binding site [nucleotide binding]; other site 246197020392 salt bridge; other site 246197020393 sequence-specific DNA binding site [nucleotide binding]; other site 246197020394 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 246197020395 Protein of unknown function (DUF664); Region: DUF664; pfam04978 246197020396 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 246197020397 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 246197020398 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 246197020399 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 246197020400 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 246197020401 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 246197020402 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 246197020403 ParB-like nuclease domain; Region: ParB; smart00470 246197020404 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 246197020405 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 246197020406 P-loop; other site 246197020407 Magnesium ion binding site [ion binding]; other site 246197020408 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 246197020409 Magnesium ion binding site [ion binding]; other site 246197020410 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 246197020411 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 246197020412 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 246197020413 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 246197020414 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 246197020415 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 246197020416 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 246197020417 putative substrate translocation pore; other site 246197020418 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 246197020419 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 246197020420 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 246197020421 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 246197020422 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 246197020423 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 246197020424 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 246197020425 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 246197020426 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 246197020427 tandem repeat interface [polypeptide binding]; other site 246197020428 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 246197020429 oligomer interface [polypeptide binding]; other site 246197020430 active site residues [active] 246197020431 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 246197020432 tandem repeat interface [polypeptide binding]; other site 246197020433 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 246197020434 oligomer interface [polypeptide binding]; other site 246197020435 active site residues [active] 246197020436 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 246197020437 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 246197020438 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 246197020439 putative DNA binding site [nucleotide binding]; other site 246197020440 putative Zn2+ binding site [ion binding]; other site 246197020441 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 246197020442 putative hydrophobic ligand binding site [chemical binding]; other site 246197020443 DoxX-like family; Region: DoxX_2; pfam13564 246197020444 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 246197020445 putative active site [active] 246197020446 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 246197020447 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 246197020448 trmE is a tRNA modification GTPase; Region: trmE; cd04164 246197020449 G1 box; other site 246197020450 GTP/Mg2+ binding site [chemical binding]; other site 246197020451 Switch I region; other site 246197020452 G2 box; other site 246197020453 Switch II region; other site 246197020454 G3 box; other site 246197020455 G4 box; other site 246197020456 G5 box; other site 246197020457 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 246197020458 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 246197020459 G-X-X-G motif; other site 246197020460 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 246197020461 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 246197020462 Haemolytic domain; Region: Haemolytic; pfam01809 246197020463 Ribonuclease P; Region: Ribonuclease_P; pfam00825 246197020464 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 246197020465 HEAT repeats; Region: HEAT_2; pfam13646